A DLI is used after a sibling or unrelated stem cell transplant. When is a DLI used? There are two main reasons why a DLI would be used: Mixed chimerism.
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What is the purpose of a DLI?
A transfer (infusion) of donated lymphocytes (white blood cells) can help manage relapse after bone marrow or stem cell transplant to treat blood cancer.
Donor lymphocyte infusion has been used in the management of relapsed hematologic malignancies after allogeneic hematopoietic cell transplantation.
A type of therapy in which lymphocytes from the blood of a donor are given to a patient who has already received a stem cell transplant from the same donor.
Nov 13, 2019 · The aim of this study was to investigate the effect of AHBMT2 or DLI on survival in relapsed transplant patients suffers from acute leukemia.
Jan 29, 2022 · Donor lymphocyte infusion (DLI) is an adoptive immunotherapy for mixed chimerism (MC) or relapsed disease after reduced-intensity conditioning ...
Donor lymphocyte infusion (DLI) is an important treatment modality in the management of relapsed hematological malignancies after allogeneic hematopoietic cell ...
Jul 12, 2018 · Allogeneic hematopoietic cell transplant or donor lymphocyte infusion appear to offer the best results in patients relapsing after 6 months from ...
Donor lymphocyte infusion differs from allogeneic bone marrow transplantation in that it is not preceded by chemotherapy and T cells are not depleted.
A univariate analysis of survival showed a significant advantage for DLI recipients, who achieved a 2-year OS from relapse of 21% ± 3%, as compared with 9% ± 2% ...
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