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Two genome-wide interaction loci modify the association of nonsteroidal anti-inflammatory drugs with colorectal cancer
Science | AAAS
We report results of the largest genome-wide GxE interaction scan to date for CRC focused on aspirin and NSAIDs. Consistent with previous...
7 months ago
Genetic risk impacts the association of menopausal hormone therapy with colorectal cancer risk
Nature
MHT use has a greater impact on the reduction of CRC risk for women at higher genetic risk. These findings have implications for the development of risk...
9 months ago
Association of regular glucosamine use with incident dementia: evidence from a longitudinal cohort and Mendelian randomization study
BMC Medicine
Emerging data suggests the neuroprotective and anti-neuroinflammatory effects of glucosamine. We aimed to examine the association between...
21 months ago
The gut microbes in inflammatory bowel disease: Future novel target option for pharmacotherapy
ScienceDirect.com
This review describes the latest research progress on the functions of gut microbes and their relationship with IBD, which can provide reference and assistance...
18 months ago
Expanding the drug discovery space with predicted metabolite–target interactions
Nature
We employed computational approaches to identify 983 potential metabolite–target interactions using the Inflammatory Bowel Disease (IBD) cohort dataset.
46 months ago