Two genome-wide interaction loci modify the association of nonsteroidal anti-inflammatory drugs with colorectal cancer - Google Search

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Two genome-wide interaction loci modify the association of nonsteroidal anti-inflammatory drugs with colorectal cancer

We report results of the largest genome-wide GxE interaction scan to date for CRC focused on aspirin and NSAIDs. Consistent with previous...
6 months ago

Genetic risk impacts the association of menopausal hormone therapy with colorectal cancer risk

MHT use has a greater impact on the reduction of CRC risk for women at higher genetic risk. These findings have implications for the development of risk...
8 months ago

Circulating inflammatory cytokines and risk of five cancers: a Mendelian randomization analysis

Epidemiological and experimental evidence has linked chronic inflammation to cancer aetiology. It is unclear whether associations for...
35 months ago

The gut microbes in inflammatory bowel disease: Future novel target option for pharmacotherapy

ScienceDirect.com

This review describes the latest research progress on the functions of gut microbes and their relationship with IBD, which can provide reference and assistance...
17 months ago

Expanding the drug discovery space with predicted metabolite–target interactions

We employed computational approaches to identify 983 potential metabolite–target interactions using the Inflammatory Bowel Disease (IBD) cohort dataset.
45 months ago

Molecular pathological epidemiology of epigenetics: emerging integrative science to analyze environment, host, and disease

Epigenetics acts as an interface between environmental/exogenous factors, cellular responses, and pathological processes.
143 months ago