To assess the transferability of tags picked from HapMap samples for association studies in other population samples, two relevant measures are (i) the distribution of the correlation (r2) between the allelic tests (based on the tags) and all 'untyped' variants (that is, SNPs not selected as tags) present in these ...
Oct 22, 2006
Transferability of tag SNPs in genetic association studies ... - PubMed
pubmed.ncbi.nlm.nih.gov › ...
These results demonstrate that the HapMap DNA samples can be used to select tags for genome-wide association studies in many samples around the world.
Transferability of tag SNPs to capture common genetic variation in DNA repair genes across multiple populations. Pac Symp Biocomput. 2006:478-86. Authors.
HapMap tagSNP transferability in multiple populations
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Our results show that HapMap tagSNPs selected with r 2 >= 0.8 can capture more than 85% of the SNPs in populations that are from the same continental group.
Genetic association studies can be made more cost-effective by exploiting linkage disequilibrium patterns between nearby single-nucleotide polymorphisms (SNPs).
Nov 23, 2006 · A general question for linkage disequilibrium-based association studies is how power to detect an association is compromised when tag SNPs ...
A general question for linkage disequilibrium-based association studies is how power to detect an association is compromised when tag SNPs are chosen from data ...
A general question for linkage disequilibrium-based association studies is how power to detect an association is compromised when tag SNPs are chosen from data ...
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Finally, we show how recent explosive growth in non-African populations means tag SNPs capture on average 30% fewer other variants than in African populations.
Jan 4, 2006 · These results show that statistical power to detect associations does not depend on the population were SNP tagging was performed.