May 17, 2022 · Pragmatic RCTs are needed to assess whether new cardiovascular therapies can reduce all-cause mortality and improve quality of life in routine ...
May 18, 2022 · The need for increased pragmatism in cardiovascular clinical trials. Nat Rev Cardiol. 2022 May 17:1–14. doi: 10.1038/s41569-022-00705-w. Epub ...
The central tenets of pragmatism in RCTs are to test interventions in routine clinical settings, with patients who are representative of broad clinical practice ...
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The most pragmatic approach would be to select an outcome that is obviously important for patients. Surrogate outcomes, composite outcomes are less pragmatic.
We explore the spectrum of pragmatism across cardiovascular clinical trials, highlighting novel innovations and trends over the past decade.
Jan 28, 2020 · Randomized controlled trials that were published in general medicine journals scored higher in pragmatism than those published in CV journals.
Dec 1, 2021 · We explore the spectrum of pragmatism across cardiovascular clinical trials, highlighting novel innovations and trends over the past decade.
May 19, 2022 · In the top 5% of all research outputs scored by Altmetric · High Attention Score compared to outputs of the same age (94th percentile) · Good ...
Sep 1, 2019 · The concept of pragmatic clinical trials is hardly new, yet as Sepehrvand et al4 show, more work is needed to break from traditional trial ...
Mar 10, 2021 · The TRANSFORM-HF trial was designed as a prospective, randomized, event-driven, pragmatic, comparative-effectiveness study to definitively compare the effect ...