Long-term outcome with respect to progression-free survival, overall survival, and relapse rate is superior after auto-allo compared with auto only.
Tandem Autologous/Reduced-Intensity Conditioning Allogeneic ...
ascopubs.org › doi › JCO.2010.32.7312
HDT with autologous stem-cell transplantation (ASCT) is part of the first-line standard treatment in patients up to the age of 65 years on the basis of the ...
Jun 20, 2013 · Tandem autologous/reduced-intensity allogeneic transplantation is superior to autologous transplantation alone in multiple myeloma. Abstract.
[PDF] Tandem autologous/reduced-intensity conditioning allogeneic ...
www.semanticscholar.org › paper
A prospective PETHEMA study of tandem autologous transplantation versus autograft followed by reduced-intensity conditioning allogeneic transplantation in newly ...
In this trial autologous stem-cell transplantation (auto) followed by reduced-intensity conditioning matched sibling donor allo (auto-allo) was compared with ...
358 myeloma patients from 26 European centres were included in a prospective study comparing ASCT-RIC versus ASCT based on the availability of an HLA identical ...
Nov 20, 2009 · Allogeneic hematopoietic stem cell transplantation with reduced intensity conditioning (RIC) is a controversial treatment in multiple myeloma.
Feb 1, 2019 · Our study showed that tandem autologous/minimal intensity allogeneic HCT for MM was safe and characterized by low acute and long-term toxicities.
Jun 20, 2013 · Long-term outcome in patients with multiple myeloma was better with auto/RICallo as compared with auto only and the auto/RICallo approach seemed to overcome ...
People also ask
What is the difference between autologous stem cell transplant and allogeneic stem cell transplant?
An autologous stem cell transplant uses a patient's own stem cells to help the patient recover after intense chemotherapy is used to treat the disease. An allogeneic transplant, which uses healthy cells from a donor, is used if the cancer has affected the bone marrow.
Which is better autologous or allogeneic?
Autologous transplants have a lower risk of life-threatening complications; there is no risk of GVHD and no need for immunosuppressive therapy to prevent GVHD and graft rejection. Immune reconstitution is more rapid than after an allogeneic transplant and there is a lower risk of opportunistic infections.
What is a tandem transplant for myeloma?
The role of tandem ASCT in multiple myeloma (MM) remains unclear and controversial. In the EMN02/HOVON95 study, as compared with single ASCT, both prolonged progression-free survival (PFS) and overall survival (OS) were seen in the tandem ASCT arm.
What are the disadvantages of autologous stem cell transplant?
Potential long-term side effects may include:
Bone damage (osteoporosis).
Cataracts.
Early menopause.
Infertility.
Interstitial lung disease.
Second cancer, which is when you develop a new type of cancer.
Allogeneic hematopoietic cell transplant (HCT) may improve long-term multiple myeloma (MM) control through the graft-versus-myeloma effect.