Prediction of Breast Cancer Risk Based on Profiling With Common Genetic Variants - Google Search

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Polygenic risk score-based prediction of breast cancer risk in Taiwanese women with dense breast using a retrospective cohort study

This study aims to explore the potential roles of PRS as candidate markers for breast cancer development and investigate the genetic profiles associated with...
6 months ago

Polygenic risk scores: An overview from bench to bedside for personalised medicine

Since the first polygenic risk score (PRS) in 2007, research in this area has progressed significantly. The increasing number of SNPs that have been...
8 months ago

Genetic landscape of interval and screen detected breast cancer - npj Precision Oncology

Interval breast cancers (IBCs) are cancers diagnosed between screening episodes. Understanding the biological differences between IBCs and...
4 months ago

Overlap of high-risk individuals predicted by family history, and genetic and non-genetic breast cancer risk prediction models: implications for risk stratification

Family history, and genetic and non-genetic risk factors can stratify women according to their individual risk of developing breast cancer.
29 months ago

Genetic risk scores not useful in predicting disease

UCL - London's Global University

Polygenic risk scores, which estimate a person's disease risk based on thousands or millions of common genetic variants, perform poorly in screening and...
11 months ago

Gene expression profiling and protein–protein network analysis revealed prognostic hub biomarkers linking cancer risk in type 2 diabetic patients

Type 2 diabetes mellitus (T2DM) and cancer are highly prevalent diseases imposing major health burden globally.
9 months ago

Predicting breast cancer risk using interacting genetic and demographic factors and machine learning

We describe a machine learning approach to identify a combination of interacting genetic variants (SNPs) and demographic risk factors for BC.
51 months ago

Will polygenic risk scores for cancer ever be clinically useful? - npj Precision Oncology

Genome-wide association studies (GWAS) have identified associations between common genetic variants, single nucleotide polymorphisms (SNPs)...
40 months ago

Validation of the BOADICEA model and a 313-variant polygenic risk score for breast cancer risk prediction in a Dutch prospective cohort

In this study we validated the association between the PRS 313 and breast cancer in a Dutch prospective cohort, its effect on predicting in situ breast cancer,
51 months ago

BOADICEA: a comprehensive breast cancer risk prediction model incorporating genetic and nongenetic risk factors

Breast cancer (BC) risk prediction allows systematic identification of individuals at highest and lowest risk. We extend the Breast and...
68 months ago