Breast cancer is the most common cancer diagnosed among women in Western countries. While rare mutations in genes such as BRCA1 and BRCA2 confer high risks of ...
Data for multiple common susceptibility alleles for breast cancer may be combined to identify women at different levels of breast cancer risk.
Prediction of Breast Cancer Risk Based on Profiling With Common Genetic Variants ; dc.contributor.author, Grenaker-Alnęs, Grethe Irene ; dc.contributor.author ...
Polygenic Risk Scores for Prediction of Breast Cancer ... - Cell Press
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Dec 13, 2018 · Stratification of women according to their risk of breast cancer based on polygenic risk scores (PRSs) could improve screening and ...
Feb 17, 2020 · Firstly, as the power of GWAS improves, variants are detected that confer lower breast cancer risk than in earlier smaller studies [57]. As a ...
May 1, 2015 · However, empirical evidence for genetic risk stratification is lacking. Methods: We investigated the value of using 77 breast cancer-associated ...
Oct 29, 2019 · Findings A weighted PRS including 116 CRC SNPs (wPRS116) showed the strongest performance. Deconstructing the PRS into multiple genetic risk ...
Michailidou K, Hall P, Gonzalez-Neira A, Ghoussaini M, Dennis J, Milne RL, et al. Large-scale genotyping identifies 41 new loci associated with breast cancer ...
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Conclusion Approximately one-half of GWAS-identified breast cancer risk variants can be directly replicated in East Asian women. Collectively, common genetic ...