In summary, PHS was associated with age at any and aggressive prostate cancer, and at death from prostate cancer in a multi-ethnic dataset. PHS performance was relatively diminished in men of African genetic ancestry, compared to performance in men of European or Asian genetic ancestry.
Feb 23, 2021
Feb 23, 2021 · A polygenic hazard score (PHS1) is associated with age at prostate cancer diagnosis and improves screening accuracy in Europeans. Here, we ...
Within European, Asian, and African ancestries, hazard ratios for prostate cancer are: 5.54, 4.49, and 2.54, respectively. PHS risk-stratifies men for any, ...
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May 8, 2020 · Within European, Asian, and African ancestries, analogous hazard ratios for PCa were 5.5 [5.2-5.9], 4.5 [3.2-6.3], and 2.5 [2.1-3.1], ...
Dec 1, 2021 · Within European, Asian, and African ancestries, hazard ratios for prostate cancer are: 5.54, 4.49, and 2.54, respectively. PHS2 risk-stratifies ...
Comparing the 80th/20th PHS2 percentiles, hazard ratios for prostate cancer, aggressive cancer, and prostate-cancer-specific death are 5.32, 5.88, and 5.68, ...
Polygenic risk scores (PRSs) of common genetic variants have shown promise in prostate cancer risk stratification, but their validity across populations has yet ...
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A polygenic hazard score (PHS1) is associated with age at prostate cancer diagnosis and improves screening accuracy in Europeans. Here, we evaluate performance ...
Feb 23, 2021 · Journal reference: Huynh-Le, M-P., et al. (2021) Polygenic hazard score is associated with prostate cancer in multi-ethnic populations.
Feb 12, 2022 · We demonstrate better genetic risk stratification for clinically significant prostate cancer than prior versions of PHS in multi-ancestry datasets.