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Myelofibrosis and allogeneic transplantation: critical points and challenges

Frontiers
In the present review, we will analyze the main controversial points of allogeneic transplantation in MF, that is, the development of more sophisticated models.
5 months ago

Allogeneic stem cell transplantation in multiple myeloma: is there still a place?

Frontiers
The introduction of novel agents dramatically improved response and outcomes of multiple myeloma (MM) and led to a sharp decline in the use of allogeneic...
5 months ago

Donor lymphocyte infusion after allogeneic haematopoietic cell transplantation for haematological malignancies: basic considerations and best practice recommendations from the EBMT

The Lancet
Since the early description of three patients with relapsed leukaemia after allogeneic haematopoietic cell transplantation (HCT) who obtained complete...
6 months ago

Measurable residual disease (MRD)-testing in haematological and solid cancers - Leukemia

Nature
MRD-testing attempts to quantify residual cancer cells when the cancer is no longer detectable by conventional methods including blood tests, biopsy or...
7 months ago

Graft-versus-Leukemia Effect Following Hematopoietic Stem Cell Transplantation for Leukemia

Frontiers
The success of hematopoietic stem cell transplantation (HSCT) lies with the ability of the engrafting immune system to remove residual leukemia cells via a...
9 months ago

A pilot study of implication of machine learning for relapse prediction after allogeneic stem cell transplantation in adults with Ph-positive acute lymphoblastic leukemia

Nature
The posttransplant relapse in Ph-positive ALL increases the risk of death. There is an unmet need for instruments to predict the risk of relapse and plan...
13 months ago

Autologous stem cell transplantation in adult patients with intermediate-risk acute myeloid leukemia in first complete remission and no detectable minimal residual disease. A comparative retrospective study with haploidentical transplants of the global committe

Nature
In patients with acute myeloid leukemia (AML) of intermediate-risk (IR) in first remission (CR1) with no measurable residual disease (MRD negative),...
15 months ago

Long-term outcomes of allogeneic stem cell transplant in multiple myeloma | Blood Cancer Journal

Nature
Allogeneic stem cell transplant (allo SCT) for multiple myeloma (MM) is potentially curative in some, while toxic in many others.
15 months ago

Current incidence, severity, and management of veno-occlusive disease/sinusoidal obstruction syndrome in adult allogeneic HSCT recipients: an EBMT Transplant Complications Working Party study | Bone Marrow Transplantation

Nature
The current incidence, diagnostic policy, management, and outcome of VOD/SOS at EBMT centers were studied. All centers that had performed allogeneic HSCTs...
15 months ago

Potential factors for and the prognostic impact of ascites after allogeneic hematopoietic stem cell transplantation

Nature
Ascites is sometimes detected after allogeneic hematopoietic stem cell transplantation (allo-HSCT); however, since limited information is currently...
15 months ago