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Disparities in Clinical Research and Cancer Treatment - CDPR24

American Association for Cancer Research

Two of the most pressing shortcomings that need to be addressed urgently are low participation in cancer clinical trials and a lack of sociodemographic...
6 months ago

Nirmatrelvir for Vaccinated or Unvaccinated Adult Outpatients with Covid-19

The New England Journal of Medicine

Nirmatrelvir in combination with ritonavir is an antiviral treatment for mild-to-moderate coronavirus disease 2019 (Covid-19). The efficacy of this...
7 months ago

Post-trial responsibilities in pragmatic clinical trials: Fulfilling the promise of research to drive real-world change

Wiley Online Library

While considerable scholarship has explored responsibilities owed to research participants at the conclusion of explanatory clinical trials,...
8 months ago

Prospective validation of a mobile health application for blood pressure management in patients with hypertensive disorders of pregnancy: study protocol for a randomized controlled trial

Hypertensive disorders of pregnancy (HDP) pose significant risks to both maternal and fetal health, contributing to global morbidity and mortality.
5 months ago

Short-term effects on physical activity level with web-based self-management support in people with COPD: a randomised controlled trial

We aimed to evaluate short-term effects of a web-based self-management support on objectively measured physical activity (PA) compared to usual care in...
1 month ago

Navigating the challenges of clinical trial professionals in the healthcare sector

Clinical trials (CTs) are essential for medical advancements but face significant challenges, particularly in professional training and role clarity.
5 months ago

Long-term efficacy and safety of a treatment strategy for HIV infection using protease inhibitor monotherapy: 8-year routine clinical care follow-up from a randomised, controlled, open-label pragmatic trial (PIVOT)

Treatment-simplification strategies are important tools for patient-centred management. We evaluated long-term outcomes from a PI monotherapy switch...
9 months ago

Widely Integrated Services in Home (WISH) for homebound older adults: a study protocol for a randomized encouragement trial

Home-based primary care (HBPC) is an emerging patient-centered, interprofessional healthcare service model that can address unmet medical needs and care...
2 weeks ago

The testing of AI in medicine is a mess. Here’s how it should be done

Hundreds of medical algorithms have been approved on basis of limited clinical data. Scientists are debating who should test these tools and how best to do it.
3 months ago

Health dialogue intervention versus opportunistic screening in primary care for type 2 diabetes and cardiovascular disease prevention in settings with low socioeconomic status (DETECT): study protocol for a pragmatic cluster-randomized trial | Trials | Full Text

Meta-analyses of randomized trials suggest that health checks and health promotion interventions targeting behavior change in primary care do not prevent...
1 month ago