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Widely Integrated Services in Home (WISH) for homebound older adults: a study protocol for a randomized encouragement trial
BMC Geriatrics
Home-based primary care (HBPC) is an emerging patient-centered, interprofessional healthcare service model that can address unmet medical...
2 weeks ago
Post-trial responsibilities in pragmatic clinical trials: Fulfilling the promise of research to drive real-world change
Wiley Online Library
While considerable scholarship has explored responsibilities owed to research participants at the conclusion of explanatory clinical trials,...
8 months ago
Health dialogue intervention versus opportunistic screening in primary care for type 2 diabetes and cardiovascular disease prevention in settings with low socioeconomic status (DETECT): study protocol for a pragmatic cluster-randomized trial | Trials | Full Text
BioMed Central
Meta-analyses of randomized trials suggest that health checks and health promotion interventions targeting behavior change in primary care...
1 month ago
Ethical and Regulatory Issues in Pragmatic Clinical Trials: Special Issue of Clinical Trials
NIH Collaboratory Rethinking Clinical Trials
Gina Uhlenbrauck. Tools for Research This page provides background and links to a series of 12 articles on the ethics and regulatory...
110 months ago
Diagnostic yield of a proactive strategy for early detection of cardiovascular disease versus usual care in adults with type 2 diabetes or chronic obstructive pulmonary disease in primary care in the Netherlands (RED-CVD): a multicentre, pragmatic, cluster-rand
The Lancet
Progressive cardiovascular diseases (eg, heart failure, atrial fibrillation, and coronary artery disease) are often diagnosed late in...
11 months ago
MultiSCRIPT-Cycle 1—a pragmatic trial embedded within the Swiss Multiple Sclerosis Cohort (SMSC) on neurofilament light chain monitoring to inform personalized treatment decisions in multiple sclerosis: a study protocol for a randomized clinical trial
BioMed Central
Treatment decisions for persons with relapsing–remitting multiple sclerosis (RRMS) rely on clinical and radiological disease activity,...
2 months ago
Integrating Randomized Comparative Effectiveness Research with Patient Care
The New England Journal of Medicine
Clinical trials of interventions in common practice can be built into the workflow of an electronic medical record. The authors review four...
102 months ago
(PDF) The ethical challenges raised in the design and conduct of pragmatic trials: An interview study with key stakeholders
ResearchGate
PDF | Background: There is a concern that the apparent effectiveness of interventions tested in clinical trials may not be an accurate reflection of.
53 months ago
Artificial intelligence guided screening for cardiomyopathies in an obstetric population: a pragmatic randomized clinical trial
Nature
Nigeria has the highest reported incidence of peripartum cardiomyopathy worldwide. This open-label, pragmatic clinical trial randomized...
3 months ago
Long-term efficacy and safety of a treatment strategy for HIV infection using protease inhibitor monotherapy: 8-year routine clinical care follow-up from a randomised, controlled, open-label pragmatic trial (PIVOT)
The Lancet
Treatment-simplification strategies are important tools for patient-centred management. We evaluated long-term outcomes from a PI...
9 months ago