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Health dialogue intervention versus opportunistic screening in primary care for type 2 diabetes and cardiovascular disease prevention in settings with low socioeconomic status (DETECT): study protocol for a pragmatic cluster-randomized trial | Trials | Full Text
BioMed Central
Meta-analyses of randomized trials suggest that health checks and health promotion interventions targeting behavior change in primary care...
4 weeks ago
MultiSCRIPT-Cycle 1—a pragmatic trial embedded within the Swiss Multiple Sclerosis Cohort (SMSC) on neurofilament light chain monitoring to inform personalized treatment decisions in multiple sclerosis: a study protocol for a randomized clinical trial
BioMed Central
Treatment decisions for persons with relapsing–remitting multiple sclerosis (RRMS) rely on clinical and radiological disease activity,...
1 month ago
Diagnostic yield of a proactive strategy for early detection of cardiovascular disease versus usual care in adults with type 2 diabetes or chronic obstructive pulmonary disease in primary care in the Netherlands (RED-CVD): a multicentre, pragmatic, cluster-rand
The Lancet
Progressive cardiovascular diseases (eg, heart failure, atrial fibrillation, and coronary artery disease) are often diagnosed late in...
10 months ago
Integrating Randomized Comparative Effectiveness Research with Patient Care
The New England Journal of Medicine
Clinical trials of interventions in common practice can be built into the workflow of an electronic medical record. The authors review four...
101 months ago
Ethical and Regulatory Issues in Pragmatic Clinical Trials: Special Issue of Clinical Trials
NIH Collaboratory Rethinking Clinical Trials
Gina Uhlenbrauck. Tools for Research This page provides background and links to a series of 12 articles on the ethics and regulatory...
109 months ago
(PDF) The ethical challenges raised in the design and conduct of pragmatic trials: An interview study with key stakeholders
ResearchGate
PDF | Background: There is a concern that the apparent effectiveness of interventions tested in clinical trials may not be an accurate reflection of.
52 months ago
Selection, optimization and validation of ten chronic disease polygenic risk scores for clinical implementation in diverse US populations
Nature
Ten were selected for implementation based on PRS performance, medical actionability and potential clinical utility, including cardiometabolic diseases and...
8 months ago
Racial and Ethnic Disparities in Health Care and Clinical Trials
Psychiatrist.com
This Academic Highlights traces the history of scientific racism from the colonization of the US to the present, illustrating the problem of...
16 months ago
Long-term efficacy and safety of a treatment strategy for HIV infection using protease inhibitor monotherapy: 8-year routine clinical care follow-up from a randomised, controlled, open-label pragmatic trial (PIVOT)
The Lancet
Treatment-simplification strategies are important tools for patient-centred management. We evaluated long-term outcomes from a PI...
8 months ago
Effect of Colonoscopy Screening on Risks of Colorectal Cancer and Related Death
The New England Journal of Medicine
In this randomized trial, the risk of colorectal cancer at 10 years was lower among participants who were invited to undergo screening colonoscopy.
24 months ago