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Functional characterization of a multi-cancer risk locus on chr5p15.33 reveals regulation of TERT by ZNF148
Nature
Genome wide association studies (GWAS) have mapped multiple independent cancer susceptibility loci to chr5p15.33.
90 months ago
Multi-ancestry genome-wide meta-analysis identifies novel basal cell carcinoma loci and shared genetic effects with squamous cell carcinoma | Communications Biology
Nature
Basal cell carcinoma (BCC) is one of the most common malignancies worldwide, yet its genetic determinants are incompletely defined.
10 months ago
Ethnicity-specific association between TERT rs2736100 (A > C) polymorphism and lung cancer risk: a comprehensive meta-analysis
Nature
The C allele of TERT rs2736100 is a risk factor for LC, NSCLC, and LUAD in different ethnic groups, and the Asian population is at a more common risk.
14 months ago
Association of rs401681 (C > T) and rs402710 (C > T) polymorphisms in the CLPTM1L region with risk of lung cancer: a systematic review and meta-analysis
Nature
Although many genome-wide association studies (GWAS) have confirmed the negative associations between rs401681[T] / rs402710[T] in the Cleft...
1 month ago
Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer
Nature
Here we report the findings of the largest Pancreatic Cancer GWAS study to date. Five novel regions of association were identified.
80 months ago
A GWAS in uveal melanoma identifies risk polymorphisms in the CLPTM1L locus
Nature
Uveal melanoma, a rare malignant tumor of the eye, is predominantly observed in populations of European ancestry. A genome-wide association...
91 months ago
Functional evaluation of TERT-CLPTM1L genetic variants associated with susceptibility of papillary thyroid carcinoma
Nature
After genotyping 2300 PTC patients and frequency-matched 2300 unaffected controls, we found that TERT rs2736100 genetic variant is significantly associated...
101 months ago
Deciphering associations for lung cancer risk through imputation and analysis of 12 316 cases and 16 831 controls
Nature
Recent genome-wide association studies have identified common variants at multiple loci influencing lung cancer risk.
115 months ago
Variants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone-related traits
Nature
Uterine leiomyomas are common benign tumors of the myometrium. We performed a meta-analysis of two genome-wide association studies of...
74 months ago