We thus performed a GWS for linkage on nine Icelandic multiple-case non-BRCA1/2 families of desirable size for mapping highly penetrant loci.

Jul 16, 2010 · Nine Icelandic BC families, unexplained by BRCA1 or BRCA2 mutations (non-BRCA1/2 families), were genotyped for a set of 811 genome-wide ...

Apr 15, 2010 · In conclusion, hereditary non-BRCA1/2 breast cancer in Iceland, as elsewhere, seems to fit a polygenic model, with low- or moderate-penetrance ...

A significant proportion of high-risk breast cancer families are not explained by mutations in known genes. Recent genome-wide searches (GWS) have not ...

Genome-wide search for breast cancer linkage in large Icelandic non-BRCA1/2 families. Breast Cancer Research, 12(4), R50. https://doi.org/10.1186/bcr2608.

Jul 16, 2010 · Conclusions: Chromosomes 2p, 6q and 14q are candidate sites for genes contributing together to high breast cancer risk. A polygenic model is ...

Chromosomes 2p, 6q and 14q are candidate sites for genes contributing together to high breast cancer risk, and a polygenic model is supported, ...

A polygenic model is supported, suggesting the joint effect of genes in contributing to breast cancer risk to be rather common in non-BRCA1/2 families. For ...

Genome-wide search for breast cancer linkage in large Icelandic non-BRCA1/2 families ... Recent genome-wide searches (GWS) have not revealed any single ...

Conclusions: Chromosomes 2p, 6q and 14q are candidate sites for genes contributing together to high breast cancer risk. A polygenic model is supported, ...