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8 days ago · Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer.
Oct 22, 2024 · Pathogenic variants in BRCA1 and BRCA2 confer a high lifetime risk of breast, ovarian and, for BRCA2, male breast and prostate cancer [1,2,3]. Genetic testing ...
5 days ago · [18] Discovery of BRCA2 followed in 1994 after linking a non-BRCA1 variant to multiple families with extensive breast cancer histories. BRCA2 was localized to ...
8 days ago · ... BRCA2 mutations were among the lowest in a Dutch cohort. This finding indicates involvement of hereditary factors in non-BRCA1/2 breast cancer families.
Aug 12, 2024 · Recent genome-wide searches (GWS) have not revealed any single major locus reminiscent of BRCA1 and BRCA2, indicating that still unidentified genes may explain ...
Mar 8, 2024 · Fanconi anemia, a rare inherited condition, may be associated with biallelic pathogenic variants in some breast cancer susceptibility genes, including BRCA2.
Dec 22, 2023 · PVs in BRCA2 are often found in patients with MBC who have multiple cases of BC/ovarian cancer (OC) in their family, but they have also been found in patients ...
Jan 26, 2024 · Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk. PLoS Genet. 2013; 9:e1003212 ...
Apr 25, 2024 · Monoallelic germline mutations truncating the BRCA2 tumor suppressor increase susceptibility to breast, ovarian, pancreatic, prostatic, and other cancers.
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Dec 5, 2023 · Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair . Nat Genet. 2015.
