We thus performed a GWS for linkage on nine Icelandic multiple-case non-BRCA1/2 families of desirable size for mapping highly penetrant loci.

A significant proportion of the families are not associated with mutations in BRCA1 or BRCA2 or other known genes [2-5] and may in part be explained by ...

A significant proportion of high-risk breast cancer families are not explained by mutations in known genes. Recent genome-wide searches (GWS) have not ...

Apr 15, 2010 · We therefore performed GWS on 12 Icelandic multiple-case non-BRCA1/2 families and followed up signs of candidate chromosomal positions by ...

Chromosomes 2p, 6q and 14q are candidate sites for genes contributing together to high breast cancer risk, and a polygenic model is supported, ...

A polygenic model is supported, suggesting the joint effect of genes in contributing to breast cancer risk to be rather common in non-BRCA1/2 families. For ...

Search by expertise, name or affiliation. Genome-wide search for breast cancer linkage in large Icelandic non-BRCA1/2 families. Adalgeir Arason, Haukur ...

Jul 16, 2010 · A polygenic model is supported, suggesting the joint effect of genes in contributing to breast cancer risk to be rather common in non-BRCA1/2 ...

Genome-wide search for breast cancer linkage in large Icelandic non-BRCA1/2 families · Arason, Adalgeir · Gunnarsson, Haukur · Johannesdottir, Gudrun · Jonasson, ...

We thus performed a GWS for linkage on nine Icelandic multiple-case non-BRCA1/2 families of desirable size for mapping highly penetrant loci. To follow up ...