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Genome-wide association study identifies multiple susceptibility loci for multiple myeloma

Multiple myeloma (MM) is a plasma cell malignancy with a significant heritable basis. Genome-wide association studies have transformed our...
101 months ago

Efficient and accurate frailty model approach for genome-wide survival association analysis in large-scale biobanks

With decades of electronic health records linked to genetic data, large biobanks provide unprecedented opportunities for systematically...
26 months ago

Sequence variation at the MTHFD1L-AKAP12 and FOPNL loci does not influence multiple myeloma survival in Sweden

Multiple myeloma (MM) is the second most common hematologic malignancy. The disease is defined by an uninhibited, clonal growth of plasma...
64 months ago

Functional dissection of inherited non-coding variation influencing multiple myeloma risk

We demonstrate that MM susceptibility is mediated by gene-regulatory changes in plasma cells and B-cells, and identify putative causal variants at six risk...
34 months ago

Genome-wide identification of potential biomarkers in multiple myeloma using meta-analysis of mRNA and miRNA expression data

We have conducted genome-wide meta-analysis of DEGs/DEMs in MM versus Normal Plasma Cells (NPCs) and derived unified putative signatures for MM.
42 months ago

Cancer health disparities in racial/ethnic minorities in the United States | British Journal of Cancer

In this review, we summarise reported disparities and associated factors in the United States of America (USA) for the most common cancers.
50 months ago