To identify susceptibility loci specific to ER-negative disease, we combined in a meta-analysis 3 genome-wide association studies of 4,193 ER-negative breast ...
Mar 27, 2013 · To identify susceptibility loci specific to ER-negative disease, we combined in a meta-analysis 3 genome-wide association studies of 4,193 ER- ...
To identify susceptibility loci specific to ER-negative disease, we combined in a meta-analysis 3 genome-wide association studies of 4,193 ER-negative breast ...
To identify susceptibility loci specific to ER-negative disease, we combined in a meta-analysis 3 genome-wide association studies of 4,193 ER-negative breast ...
Dive into the research topics of 'Genome-wide association studies identify four ER negative-specific breast cancer risk loci'. Together they form a unique ...
Nov 20, 2024 · To identify susceptibility loci specific to ER-negative disease, we combined in a meta-analysis 3 genome-wide association studies of 4,193 ER- ...
To identify susceptibility loci specific to ER-negative disease, we combined in a meta-analysis 3 genome-wide association studies of 4,193 ER-negative breast ...
People also ask
What are genomic biomarkers for breast cancer risk?
Genomic biomarkers for breast cancer are comprised of rare highly penetrant mutations of genes such as BRCA1 or BRCA2, moderately penetrant mutations of genes such as CHEK2, as well as more common genomic variants, including single nucleotide polymorphisms, associated with modest effect sizes.
Is ER negative breast cancer hereditary?
Approximately 20% of the tumours in our cases were ER-negative and this proportion was similar whether or not a family member was also affected by breast cancer. Overall, we found no statistically significant difference in the FRRs for relatives of ER-negative patients and those for relatives of ER-positive cases.
What are the genomic subtypes of breast cancer?
Gallen International Breast Cancer Congress, more than five molecular subtypes of BC can be defined, i.e., luminal A, luminal B, human epidermal growth factor receptor 2 (HER2) + B2, HER2 overexpression, basal-like triple-negative breast cancer (TNBC), and other subtypes.
What are the 3 types of genes linked to cancer?
The main types of genes that play a role in cancer are oncogenes, tumor suppressor genes, and DNA repair genes.
Dive into the research topics of 'Genome-wide association studies identify four ER negative-specific breast cancer risk loci'. Together they form a unique ...
Estrogen receptor (ER)-negative tumors represent 20-30% of all breast cancers, with a higher proportion occurring in younger women and women of African ancestry ...
Estrogen receptor (ER)-negative tumors represent 20-30% of all breast cancers, with a higher proportion occurring in younger women and women of African ...