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Immunogenetics of lithium response and psychiatric phenotypes in patients with bipolar disorder

We performed an exploratory study of the contributions of immune-relevant genetic factors to the response to lithium (Li) treatment and the clinical...
6 months ago

Exploring hub genes and crucial pathways linked to oxidative stress in bipolar disorder depressive episodes through bioinformatics analysis

BackgroundBipolar disorder (BD) is a complex and serious psychiatric condition primarily characterized by bipolar depression, with the underlying genetic...
6 months ago

Lithium response in bipolar disorder is associated with focal adhesion and PI3K-Akt networks: a multi-omics replication study

Lithium is the gold standard treatment for bipolar disorder (BD). However, its mechanism of action is incompletely understood,...
7 months ago

Patterns of Convergence and Divergence Between Bipolar Disorder Type I and Type II: Evidence From Integrative Genomic Analyses

We aimed to investigate the genetic overlap and distinction of bipolar type I (BD I) & type II (BD II) by conducting integrative post-GWAS analyses.
3 months ago

Single-cell multiomics analysis reveals cell/tissue-specific associations in bipolar disorder | Translational Psychiatry

This study investigates the cellular origin and tissue heterogeneity in bipolar disorder (BD) by integrating multiomics data.
2 months ago

White and gray matter alterations in bipolar I and bipolar II disorder subtypes compared with healthy controls – exploring associations with disease course and polygenic risk | Neuropsychopharmacology

Patients with bipolar disorder (BD) show alterations in both gray matter volume (GMV) and white matter (WM) integrity compared with healthy controls (HC).
8 months ago

Causal role of immune cells in bipolar disorder: a Mendelian randomization study

This MR investigation reveals associations between immune cell phenotypes, bipolar disorder, and genetics, providing novel perspectives on prospective...
1 month ago

Combining schizophrenia and depression polygenic risk scores improves the genetic prediction of lithium response in bipolar disorder patients

Lithium is the gold standard therapy for Bipolar Disorder (BD) but its effectiveness differs widely between individuals.
34 months ago

Exploring lithium’s transcriptional mechanisms of action in bipolar disorder: a multi-step study

Lithium has been the first-line treatment for bipolar disorder (BD) for more than six decades. Although the molecular effects of lithium...
59 months ago

Focal adhesion is associated with lithium response in bipolar disorder: evidence from a network-based multi-omics analysis

The aim of this study is to identify functional genes and pathways that distinguish BD Li responders (LR) from BD Li non-responders (NR).
18 months ago