Jun 12, 2024 · We found that clinical response to Li treatment, measured with the Alda scale, was associated with a diminished burden of mania, depression, ...
Dec 2, 2023 · We found that clinical response to Li treatment, measured with the Alda scale, was associated with a diminished burden of mania, depression, substance and ...
Our genetic analyses showed that a stronger clinical response to Li was modestly related to lower polygenic load for diabetes and hypertension in BP-I but not ...
People also ask
What are the predictors of lithium response in bipolar disorder?
Specifically, a pattern of mania (M), depression (D), and euthymic interval (I) has been shown to positively predict lithium response.
How is lithium related to bipolar disorder?
Lithium may work by changing the release of chemicals like dopamine or serotonin in your brain. Taking lithium helps you to have more control over your emotions. It helps you cope better with bipolar mood swings. It may take several weeks to months for lithium to start working.
How do genetics play a role in bipolar disorder?
Genetic factors and bipolar disorder
If one parent has bipolar disorder, there's a 10% chance that their child will develop the illness. If both parents have bipolar disorder, the likelihood of their child developing bipolar disorder rises to 40%.
What percent of bipolar patients respond to lithium?
Finally, a recent systematic review and meta-analysis concluded that among 71 lithium identified randomized or observational studies [N = 30 542] two-thirds of participants attained a clinically significant improvement in manic or depressive symptoms, and over 50% achieved remission across varying outcome measures, ...
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For this, we studied how Li response and linked genes associate with the psychiatric symptoms and polygenic load for medical comorbidities, placing particular ...
Apr 3, 2024 · We performed an exploratory study of the contributions of immune-relevant genetic factors to the response to lithium (Li) treatment and the clinical ...
Mar 25, 2021 · In this article, we delineate the mechanisms of action of lithium and summarize the results of genetic research on lithium response and side effects.
Feb 23, 2024 · We found that focal adhesion, the extracellular matrix (ECM), and PI3K-Akt signaling networks were associated with response to lithium.
Exploring the genetics of lithium response in bipolar disorders. Herrera-Rivero, Marisol; Adli, Mazda; Akiyama, Kazufumi; Akula, Nirmala; Amare, Azmeraw T; ...
Aug 19, 2009 · Response to lithium seems to cluster in families and can be used as a predictor for recurrence of BD symptoms. While molecular studies have ...
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Exploring Genetic Variability at PI, GSK3, HPA ... HLA-DRB1 and HLA-DQB1 genetic diversity modulates response to lithium in bipolar affective disorders.