Google
×
Past year
  • Any time
  • Past hour
  • Past 24 hours
  • Past week
  • Past month
  • Past year
All results
Oct 21, 2024 · The objective of our study was to explore the potential of using a polygenic risk score (PRS) to estimate the overall genetic risk of developing breast or ...
Mar 15, 2024 · Evaluation of polygenic risk scores for breast and ovarian cancer risk prediction in BRCA1 and BRCA2 mutation carriers. J. Natl. Cancer Inst. 109(7), djw302 ...
Nov 12, 2023 · Single nucleotide polymorphisms (SNPs) in the form of a polygenic risk score (PRS) have emerged as a promising factor that could improve the predictive ...
May 8, 2024 · This study validates and compares the risk prediction ability of two widely used polygenic risk score (PRS) sets, PRS77 and PRS313, in a population of Czech ...
Jun 5, 2024 · The model performance was similar when evaluated separately in BRCA1 or BRCA2 PV carriers. The full model identified 5.8%, 12.9% and 24.0% of BRCA1/2 PV ...
Mar 8, 2024 · Cumulative ovarian cancer risk is 39% in BRCA1 carriers and ranges from 11% to 17% in BRCA2 carriers. Having a BRCA1/BRCA2 pathogenic variant elevates risks for ...
Feb 29, 2024 · Having a PRS >90th percentile had a similar hazard ratio for breast cancer and predicted a similar cumulative incidence to being PV+ or FH+ unselected for PRS, ...
Oct 22, 2024 · Polygenic Risk Scores (PRS) are a major component of accurate breast cancer risk prediction and have the potential to improve screening and prevention ...
Feb 8, 2024 · Ovarian cancer risk was calculated to be between 41% and 58% for BRCA1 carriers and between 15% and 16.5% for BRCA2 carriers at age 70 [7,8].
Oct 9, 2024 · Polygenic risk score (PRS) and rare monogenic variant screening are valuable tools for predicting cancer risk and identifying individuals at high risk.