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Neuroimaging and fluid biomarkers in Parkinson’s disease in an era of targeted interventions

Nature
We consider new imaging approaches showing sensitivity to brain tissue composition, and examine novel fluid biomarkers showing specificity for pathological...
5 months ago

Relevance of Aβ42/40 Ratio for Detection of Alzheimer Disease Pathology in Clinical Routine: The PLMR Scale

Frontiers
Background: Cerebrospinal fluid (CSF) biomarkers (Aβ peptides and tau proteins) improved the diagnosis of Alzheimer's disease (AD) in research and clinical...
5 months ago

Novel Biomarkers for Alzheimer’s Disease: Plasma Neurofilament Light and Cerebrospinal Fluid

Wiley Online Library
This literature review focuses on plasma neurofilament light (NfL) and CSF NfL as blood-based biomarkers used in recent AD diagnosis.
6 months ago

Biofluid biomarkers for Alzheimer’s disease

Frontiers
Alzheimer's disease (AD) is a multifactorial neurodegenerative disease, with a complex pathogenesis and an irreversible course.
5 months ago

Dementia with Lewy bodies: an update and outlook

Molecular Neurodegeneration
Dementia with Lewy bodies (DLB) is an age-associated neurodegenerative disorder producing progressive cognitive decline that interferes with normal life and...
70 months ago

14-3-3 proteins—a moonlight protein complex with therapeutic potential in neurological disorder: in-depth review with Alzheimer’s disease

Frontiers
Alzheimer's disease (AD) affects millions of people worldwide and is a gradually worsening neurodegenerative condition. The accumulation of abnormal...
5 months ago

CSF proteome profiling reveals biomarkers to discriminate dementia with Lewy bodies from Alzheimer´s disease

Nature
Diagnosis of dementia with Lewy bodies (DLB) is challenging and specific biofluid biomarkers are highly needed.
14 months ago

Added value of cerebrospinal fluid multimarker analysis in diagnosis and progression of dementia

Wiley Online Library
The added value of emerging cerebrospinal fluid (CSF) markers (Aβ40, Aβ38, BACE-1, neurogranin [ng], phosphorylated neurofilament heavy...
48 months ago

Cerebrospinal Fluid Biomarker Candidates for Parkinsonian Disorders

Frontiers
Reliable biomarkers are needed for early and accurate diagnosis, to measure disease progression, and response to therapy.
9 months ago

Discovery of novel CSF biomarkers to predict progression in dementia using machine learning | Scientific Reports

Nature
Providing an accurate prognosis for individual dementia patients remains a challenge since they greatly differ in rates of cognitive decline...
19 months ago