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Neuroimaging and fluid biomarkers in Parkinson’s disease in an era of targeted interventions
Nature
We consider new imaging approaches showing sensitivity to brain tissue composition, and examine novel fluid biomarkers showing specificity for pathological...
4 months ago
14-3-3 proteins—a moonlight protein complex with therapeutic potential in neurological disorder: in-depth review with Alzheimer’s disease
Frontiers
Alzheimer's disease (AD) affects millions of people worldwide and is a gradually worsening neurodegenerative condition. The accumulation of abnormal...
4 months ago
Novel Biomarkers for Alzheimer’s Disease: Plasma Neurofilament Light and Cerebrospinal Fluid
Wiley Online Library
Neurodegenerative disorders such as Alzheimer's disease (AD) represent an increasingly significant public health concern. As clinical diagnosis faces...
5 months ago
Potential New Approaches for Diagnosis of Alzheimer's Disease and Related Dementias
Frontiers
Dementia is an umbrella term—caused by a large number of specific diagnoses, including several neurodegenerative disorders. Alzheimer's disease (AD) is now...
8 months ago
CSF proteome profiling reveals biomarkers to discriminate dementia with Lewy bodies from Alzheimer´s disease
Nature
Diagnosis of dementia with Lewy bodies (DLB) is challenging and specific biofluid biomarkers are highly needed. We employed proximity extension-based assays...
13 months ago
The use of neuroimaging techniques in the early and differential diagnosis of dementia
Nature
This review summarises findings from diagnostic brain imaging studies, discusses novel developments in molecular imaging and outlines important future...
14 months ago
Amyloid β-based therapy for Alzheimer’s disease: challenges, successes and future
Nature
Amyloid β protein (Aβ) is the main component of neuritic plaques in Alzheimer's disease (AD), and its accumulation has been considered as the molecular...
16 months ago
Advances and applications of fluids biomarkers in diagnosis and therapeutic targets of Alzheimer's disease
Wiley Online Library
This review aims to provide an overview of application and potential value of AD biomarkers in fluids, including cerebrospinal fluid, blood, and saliva, in...
18 months ago
Discovery of novel CSF biomarkers to predict progression in dementia using machine learning | Scientific Reports
Nature
Providing an accurate prognosis for individual dementia patients remains a challenge since they greatly differ in rates of cognitive decline.
18 months ago
Opportunities and challenges of alpha-synuclein as a potential biomarker for Parkinson’s disease and other synucleinopathies
Nature
Parkinson's disease (PD), the second most common progressive neurodegenerative disease, develops and progresses for 10–15 years before the clinical...
27 months ago