The heritability of sporadic ALS was estimated as 0.61 (0.38 to 0.78) with the unshared environmental component 0.39 (0.22 to 0.62).
Sep 22, 2010 · The heritability of sporadic ALS was estimated as 0.61 (0.38 to 0.78) with the unshared environmental component 0.39 (0.22 to 0.62). ALS has a high ...
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We agree that genetic studies have so far explained only a small fraction of the heritability of ALS (1,2), and this is true in many other diseases as well (3).
Jul 22, 2019 · We have shown that the overall heritability of ALS in this population is 52.3%. We have found that, in the absence of known ALS-associated ...
No dizygotic twin pairs were concordant-affected, and 122 discordant-affected. The heritability of sporadic ALS was estimated as 0.61 (0.38 to 0.78) with the ...
No dizygotic twin pairs were concordant-affected, and 122 discordant-affected. The heritability of sporadic ALS was estimated as 0.61 (0.38 to 0.78) with the ...
The British motor neuron disease (MND) twin study found ALS heritability to be between 38 and 85%, using 76 twin pairs [7].
Jan 20, 2023 · Twin studies4, a prospective population-based studies5 or register studies6 indicated a heritability ranging from 40 to 60%, while 5–10% of ALS ...
Jul 14, 2014 · This range is narrowed only slightly when stratifying the analysis by type of ALS: twin concordance is estimated to be between 60% and 86% when ...
There is still a large “missing heritability” to be discovered, with an estimated heritability by twin data as high as 65% (Al-Chalabi et al., 2010), while just ...