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A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor–negative breast cancer

Nature
Christopher Haiman and colleagues report a genome-wide association study for estrogen receptor (ER)-negative breast cancer in women of...
157 months ago

Functional evaluation of TERT-CLPTM1L genetic variants associated with susceptibility of papillary thyroid carcinoma

Nature
After genotyping 2300 PTC patients and frequency-matched 2300 unaffected controls, we found that TERT rs2736100 genetic variant is significantly associated...
102 months ago

Common variation and heritability estimates for breast, ovarian and prostate cancers

Nature
The studies from COGS included in this collection nearly double the number of common genetic variants significantly associated with susceptibility to breast,...
140 months ago

Functional characterization of a multi-cancer risk locus on chr5p15.33 reveals regulation of TERT by ZNF148

Nature
Our results indicate that the association with chr5p15.33-Region 2 may be explained by rs36115365, a variant influencing TERT expression via ZNF148.
91 months ago

Variants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone-related traits

Nature
Uterine leiomyomas are common benign tumors of the myometrium. We performed a meta-analysis of two genome-wide association studies of...
74 months ago

Capture Hi-C identifies putative target genes at 33 breast cancer risk loci

Nature
Genome-wide association studies (GWAS) have identified approximately 100 breast cancer risk loci. Translating these findings into a greater...
80 months ago

Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1

Nature
High-risk mutations in several genes predispose to both colorectal cancer (CRC) and endometrial cancer (EC). We therefore hypothesised that...
108 months ago

Functional annotation of susceptibility loci identified by COGS

Nature
It is likely that many of the cancer risk loci found by COGS influence gene regulation, as ~66% of confirmed susceptibility alleles lie within or near genes.
140 months ago

Genome-wide association study of breast cancer in Latinas identifies novel protective variants on 6q25

Nature
The genetic contributions to breast cancer development among Latinas are not well understood. Here we carry out a genome-wide association...
121 months ago

2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy

Nature
Large population-based registry studies have shown that breast cancer prognosis is inherited. Here we analyse single-nucleotide...
125 months ago