WO2009149171A4 - Fgf21 mutants and uses thereof - Google Patents

Fgf21 mutants and uses thereof Download PDF

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Publication number
WO2009149171A4
WO2009149171A4 PCT/US2009/046113 US2009046113W WO2009149171A4 WO 2009149171 A4 WO2009149171 A4 WO 2009149171A4 US 2009046113 W US2009046113 W US 2009046113W WO 2009149171 A4 WO2009149171 A4 WO 2009149171A4
Authority
WO
WIPO (PCT)
Prior art keywords
new
fusion polypeptide
seq
polypeptide
sequence
Prior art date
Application number
PCT/US2009/046113
Other languages
French (fr)
Other versions
WO2009149171A3 (en
WO2009149171A2 (en
Inventor
Edward John Belouski
Murielle Marie Ellison
Agnes Eva Hamburger
Randy Ira Hecht
Yue-Sheng Li
Mark Leo Michaels
Jeonghoon Sun
Jing Xu
Original Assignee
Amgen Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40984291&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2009149171(A4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to BR122020010972-6A priority Critical patent/BR122020010972B1/en
Priority to CN200980130476.4A priority patent/CN102143758B/en
Priority to UAA201015922A priority patent/UA102395C2/en
Priority to BRPI0911385A priority patent/BRPI0911385B8/en
Priority to KR1020167010524A priority patent/KR101787300B1/en
Priority to EP09759330.5A priority patent/EP2296690B1/en
Priority to MX2010013333A priority patent/MX2010013333A/en
Priority to NZ590050A priority patent/NZ590050A/en
Priority to CA2726589A priority patent/CA2726589C/en
Application filed by Amgen Inc. filed Critical Amgen Inc.
Priority to AU2009256232A priority patent/AU2009256232B2/en
Priority to MX2012002985A priority patent/MX346396B/en
Priority to EA201001883A priority patent/EA017690B1/en
Priority to JP2011512611A priority patent/JP2011523561A/en
Priority to MA34197A priority patent/MA33142B1/en
Publication of WO2009149171A2 publication Critical patent/WO2009149171A2/en
Publication of WO2009149171A3 publication Critical patent/WO2009149171A3/en
Publication of WO2009149171A4 publication Critical patent/WO2009149171A4/en
Priority to IL209395A priority patent/IL209395A/en
Priority to TNP2010000563A priority patent/TN2010000563A1/en
Priority to ZA2010/08778A priority patent/ZA201008778B/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/01—DNA viruses
    • C07K14/03—Herpetoviridae, e.g. pseudorabies virus
    • C07K14/05—Epstein-Barr virus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factors [FGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Abstract

The invention provides nucleic acid molecules encoding FGF21 mutant polypeptides, FGF21 mutant polypeptides, pharmaceutical compositions comprising FGF21 mutant polypeptides, and methods for treating metabolic disorders using such nucleic acids, polypeptides, or pharmaceutical compositions.

Claims

AMENDED CLAIMS received by the International Bureau on 17 March 2010 (17.03.10)
51. (New) A polypeptide comprising the amino acid sequence of SEQ ID NO:4, further comprising the mutations L98R and P 171 G.
52. (New) A fusion polypeptide comprising the polypeptide of claim 51 linked to a heterologous sequence.
53. (New) The fusion polypeptide of claim 52, wherein, the heterologous sequence is a Fc sequence.
54. (New) The fusion polypeptide of claim 53, wherein the Fc sequence comprises the amino acid sequence of SEQ ID NO: 13.
55. (New) The fusion polypeptide of claim 54, wherein the polypeptide is joined to the heterologous sequence by a linker.
56. (New) The fusion polypeptide of claim 55 wherein the linker is GGGGGSGGGSGGGGS (SEQ ID NO.-23).
57. (New) The fusion polypeptide of claim 55 wherein the linker is GGGGSGGGGSGGGGS (SEQ ID NO:31).
58. (New) The fusion polypeptide 56, wherein the fusion polypeptide is encoded by the nucleic acid sequence of SEQ ED NO:37.
59. (New) A multimer comprising two or more copies of the fusion polypeptide of claim 58.
60. (New) A pharmaceutical composition comprising the fusion polypeptide of claim 58 and a pharmaceutically acceptable formulation agent.
PCT/US2009/046113 2008-06-04 2009-06-03 Fgf21 mutants and uses thereof WO2009149171A2 (en)

Priority Applications (17)

Application Number Priority Date Filing Date Title
MA34197A MA33142B1 (en) 2008-06-04 2009-06-03 FGF21 MUTANTS AND USES THEREOF
MX2012002985A MX346396B (en) 2008-06-04 2009-06-03 Fgf21 mutants and uses thereof.
AU2009256232A AU2009256232B2 (en) 2008-06-04 2009-06-03 FGF21 mutants and uses thereof
EA201001883A EA017690B1 (en) 2008-06-04 2009-06-03 Fgf21 mutants and uses thereof
CN200980130476.4A CN102143758B (en) 2008-06-04 2009-06-03 Fgf21 mutant and uses thereof
EP09759330.5A EP2296690B1 (en) 2008-06-04 2009-06-03 Fgf21 mutants and uses thereof
MX2010013333A MX2010013333A (en) 2008-06-04 2009-06-03 Fgf21 mutants and uses thereof.
NZ590050A NZ590050A (en) 2008-06-04 2009-06-03 Fgf21 mutants and uses thereof
CA2726589A CA2726589C (en) 2008-06-04 2009-06-03 Fgf21 mutants and uses thereof
BR122020010972-6A BR122020010972B1 (en) 2008-06-04 2009-06-03 isolated and fusion polypeptide, its pharmaceutical composition and multimer
UAA201015922A UA102395C2 (en) 2008-06-04 2009-06-03 Fgf21 mutants and use thereof
KR1020167010524A KR101787300B1 (en) 2008-06-04 2009-06-03 Fgf21 mutants and uses thereof
BRPI0911385A BRPI0911385B8 (en) 2008-06-04 2009-06-03 isolated polypeptide, fusion polypeptide, multimer and pharmaceutical composition
JP2011512611A JP2011523561A (en) 2008-06-04 2009-06-03 FGF21 mutants and uses thereof
IL209395A IL209395A (en) 2008-06-04 2010-11-17 Fgf21 mutants and pharmaceutical compositions comprising them
TNP2010000563A TN2010000563A1 (en) 2009-06-03 2010-12-03 Fgf 21 mutants and uses thereof
ZA2010/08778A ZA201008778B (en) 2008-06-04 2010-12-07 Fgf21 mutants and uses thereof

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US5886108P 2008-06-04 2008-06-04
US5891908P 2008-06-04 2008-06-04
US61/058,861 2008-06-04
US61/058,919 2008-06-04
US16436409P 2009-03-27 2009-03-27
US61/164,364 2009-03-27
US17573609P 2009-05-05 2009-05-05
US61/175,736 2009-05-05

Publications (3)

Publication Number Publication Date
WO2009149171A2 WO2009149171A2 (en) 2009-12-10
WO2009149171A3 WO2009149171A3 (en) 2010-03-11
WO2009149171A4 true WO2009149171A4 (en) 2010-05-06

Family

ID=40984291

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/046113 WO2009149171A2 (en) 2008-06-04 2009-06-03 Fgf21 mutants and uses thereof

Country Status (23)

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US (9) US8034770B2 (en)
EP (1) EP2296690B1 (en)
JP (5) JP2011523561A (en)
KR (2) KR101651697B1 (en)
CN (1) CN102143758B (en)
AR (1) AR072009A1 (en)
AU (1) AU2009256232B2 (en)
BR (2) BRPI0911385B8 (en)
CA (1) CA2726589C (en)
CL (1) CL2010001346A1 (en)
CO (1) CO6341566A2 (en)
CR (1) CR11851A (en)
EA (3) EA024751B8 (en)
IL (1) IL209395A (en)
JO (1) JOP20190083A1 (en)
MA (1) MA33142B1 (en)
MX (2) MX346396B (en)
MY (1) MY152721A (en)
NZ (1) NZ590050A (en)
PE (1) PE20100253A1 (en)
SG (1) SG193860A1 (en)
TW (2) TWI526220B (en)
WO (1) WO2009149171A2 (en)

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