WO2006119054A3 - Multi-step process for the manufacture of therapeutic protein - Google Patents

Multi-step process for the manufacture of therapeutic protein Download PDF

Info

Publication number
WO2006119054A3
WO2006119054A3 PCT/US2006/016334 US2006016334W WO2006119054A3 WO 2006119054 A3 WO2006119054 A3 WO 2006119054A3 US 2006016334 W US2006016334 W US 2006016334W WO 2006119054 A3 WO2006119054 A3 WO 2006119054A3
Authority
WO
WIPO (PCT)
Prior art keywords
protein
manufacture
therapeutic protein
step process
culturing
Prior art date
Application number
PCT/US2006/016334
Other languages
French (fr)
Other versions
WO2006119054A2 (en
Inventor
Lauri Laurene Jenkins
Jay Irving Kennedy
Victor Sisto Lusvardi
Colleen Merritt Severyn
Toni T Butler
Original Assignee
Du Pont
Lauri Laurene Jenkins
Jay Irving Kennedy
Victor Sisto Lusvardi
Colleen Merritt Severyn
Toni T Butler
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont, Lauri Laurene Jenkins, Jay Irving Kennedy, Victor Sisto Lusvardi, Colleen Merritt Severyn, Toni T Butler filed Critical Du Pont
Priority to JP2008509188A priority Critical patent/JP2008538929A/en
Priority to EP06751824A priority patent/EP1874916A2/en
Publication of WO2006119054A2 publication Critical patent/WO2006119054A2/en
Publication of WO2006119054A3 publication Critical patent/WO2006119054A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/28—Constructional details, e.g. recesses, hinges disposable or single use
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Abstract

A process for the production of therapeutic protein is provided, which includes the steps of preparing nutrient medium for culturing of cells to express the protein, culturing the cells in the presence of the nutrient medium to express the protein, preparing protein separation solution for isolating the protein, formulating the isolated protein, and storing the formulated protein, at least three of these steps being carried out in separate disposable containers made of flexible film, at least the interior of said surface of said container being made of fluoropolymer.
PCT/US2006/016334 2005-04-29 2006-04-28 Multi-step process for the manufacture of therapeutic protein WO2006119054A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2008509188A JP2008538929A (en) 2005-04-29 2006-04-28 Multi-step process for producing therapeutic proteins
EP06751824A EP1874916A2 (en) 2005-04-29 2006-04-28 Multi-step process for the manufacture of therapeutic protein

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US67633605P 2005-04-29 2005-04-29
US67612905P 2005-04-29 2005-04-29
US67652805P 2005-04-29 2005-04-29
US67633705P 2005-04-29 2005-04-29
US60/676,336 2005-04-29
US60/676,129 2005-04-29
US60/676,337 2005-04-29
US60/676,528 2005-04-29

Publications (2)

Publication Number Publication Date
WO2006119054A2 WO2006119054A2 (en) 2006-11-09
WO2006119054A3 true WO2006119054A3 (en) 2006-12-28

Family

ID=36936474

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/016334 WO2006119054A2 (en) 2005-04-29 2006-04-28 Multi-step process for the manufacture of therapeutic protein

Country Status (3)

Country Link
EP (1) EP1874916A2 (en)
JP (1) JP2008538929A (en)
WO (1) WO2006119054A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11357857B2 (en) 2014-06-20 2022-06-14 Comera Life Sciences, Inc. Excipient compounds for protein processing
US10478498B2 (en) 2014-06-20 2019-11-19 Reform Biologics, Llc Excipient compounds for biopolymer formulations
WO2015196091A1 (en) * 2014-06-20 2015-12-23 Reform Biologics, Llc Viscosity-reducing excipient compounds for protein formulations
US10280390B2 (en) 2014-12-22 2019-05-07 Saint-Gobain Performance Plastics Corporation System for culture of cells in a controlled environment
US20160178491A1 (en) 2014-12-22 2016-06-23 Saint-Gobain Performance Plastics Corporation Capture system of cells and methods
JP6165280B2 (en) * 2015-01-29 2017-07-19 ダイキン工業株式会社 Cell culture equipment
JP2018520370A (en) 2015-06-05 2018-07-26 ヴェセレ，ウィリアム ティー．ＶＥＣＥＲＥ，Ｗｉｌｌｉａｍ Ｔ． Low transmittance sample bag
JP6206612B1 (en) * 2017-03-07 2017-10-04 東洋インキＳｃホールディングス株式会社 Cell culture bags
JP2022517554A (en) * 2018-12-31 2022-03-09 サン－ゴバン パフォーマンス プラスティックス コーポレイション Container containing degradable carrier
JP2023511024A (en) * 2019-12-30 2023-03-16 サン－ゴバン パフォーマンス プラスティックス コーポレイション Containers and methods for cell transduction

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4800023A (en) * 1987-02-02 1989-01-24 Steridose Systems Method of aseptic treatment of water and a storage container to be used at such treatment
US4847462A (en) * 1986-11-06 1989-07-11 American Fluoroseal Corporation Method and apparatus for making fluorocarbon film plastic bags using a laser
US5362642A (en) * 1993-02-10 1994-11-08 Hyclone Laboratories Methods and containment system for storing, reconstituting, dispensing and harvesting cell culture media
US5686304A (en) * 1995-12-15 1997-11-11 Avecor Cardiovascular, Inc. Cell culture apparatus and method
US20040236083A1 (en) * 2003-05-14 2004-11-25 Libert Sharon Ann Protein separation column

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4847462A (en) * 1986-11-06 1989-07-11 American Fluoroseal Corporation Method and apparatus for making fluorocarbon film plastic bags using a laser
US4800023A (en) * 1987-02-02 1989-01-24 Steridose Systems Method of aseptic treatment of water and a storage container to be used at such treatment
US5362642A (en) * 1993-02-10 1994-11-08 Hyclone Laboratories Methods and containment system for storing, reconstituting, dispensing and harvesting cell culture media
US5686304A (en) * 1995-12-15 1997-11-11 Avecor Cardiovascular, Inc. Cell culture apparatus and method
US20040236083A1 (en) * 2003-05-14 2004-11-25 Libert Sharon Ann Protein separation column

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GARLAND R J ET AL: "The use of Teflon cell culture bags to expand functionally active CD8<+> cytotoxic T lymphocytes", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM, NL, vol. 227, no. 1-2, 30 July 1999 (1999-07-30), pages 53 - 63, XP004178042, ISSN: 0022-1759 *
LAURI JENKINS ET AL: "Consider using Fluoropolymers in Biological Application", INTERNET ARTICLE- CHEMICAL ENGINEERING PROGRESS, vol. 100, no. 12, December 2004 (2004-12-01), XP002398330, Retrieved from the Internet <URL:http://www2.dupont.com/Teflon_Industrial/en_US/assets/downloads/article_biological_apps.pdf#search=%22JENKINS%20CONSIDER%20USING%20%20CHEMICLA%20ENGINEERING%22> *

Also Published As

Publication number Publication date
JP2008538929A (en) 2008-11-13
WO2006119054A2 (en) 2006-11-09
EP1874916A2 (en) 2008-01-09

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