WO2003033520A3 - Anticancer vaccine and diganostic methods and reagents - Google Patents

Anticancer vaccine and diganostic methods and reagents Download PDF

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Publication number
WO2003033520A3
WO2003033520A3 PCT/US2002/030289 US0230289W WO03033520A3 WO 2003033520 A3 WO2003033520 A3 WO 2003033520A3 US 0230289 W US0230289 W US 0230289W WO 03033520 A3 WO03033520 A3 WO 03033520A3
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WO
WIPO (PCT)
Prior art keywords
cells
protein
provides
apcs
patient
Prior art date
Application number
PCT/US2002/030289
Other languages
French (fr)
Other versions
WO2003033520A2 (en
Inventor
Olivera J Finn
Henry Kao
Donald Hunt
Jarrod A Marto
Original Assignee
Univ Pittburgh Of The Commonwe
Univ Virginia
Olivera J Finn
Henry Kao
Donald Hunt
Jarrod A Marto
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pittburgh Of The Commonwe, Univ Virginia, Olivera J Finn, Henry Kao, Donald Hunt, Jarrod A Marto filed Critical Univ Pittburgh Of The Commonwe
Priority to AU2002361559A priority Critical patent/AU2002361559A1/en
Priority to EP02797036A priority patent/EP1435776A4/en
Publication of WO2003033520A2 publication Critical patent/WO2003033520A2/en
Publication of WO2003033520A3 publication Critical patent/WO2003033520A3/en
Priority to US12/698,822 priority patent/US8211436B2/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4615—Dendritic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
    • A61K39/4622—Antigen presenting cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464448—Regulators of development
    • A61K39/464449—Cell cycle regulated proteins, e.g. cyclin, CDC, CDK or INK-CCR
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4738—Cell cycle regulated proteins, e.g. cyclin, CDC, INK-CCR
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
    • A61K2239/49—Breast
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Abstract

The invention provides a method of priming T cells against tumor antigens comprising by obtaining naïve CD4?+ or DC8+¿ T cells from at least one healthy individual, obtaining at least one protein or peptide from at least one cancerous cell; obtaining antigen presenting cells (APCs), culturing the APCs with the at least one protein or peptide, and adding the T cells to the culture of the APCs. The primed T cells can then be employed to identify the antigens or therapeutically as prophylaxis or treatment for cancers. The invention also provides cyclin molecules, and fragments derived from cyclin molecules, as tumor antigens. The invention provides a method for diagnosing a malignant or pre-malignant condition within a patient. The invention also provides a method for vaccinating a patient against malignancies comprising introducing a protein or peptide consisting essentially of all or an immunogenic fragment of a cyclin protein into the patient.
PCT/US2002/030289 2001-09-24 2002-09-24 Anticancer vaccine and diganostic methods and reagents WO2003033520A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2002361559A AU2002361559A1 (en) 2001-09-24 2002-09-24 Anticancer vaccine and diganostic methods and reagents
EP02797036A EP1435776A4 (en) 2001-09-24 2002-09-24 Anticancer vaccine and diganostic methods and reagents
US12/698,822 US8211436B2 (en) 2001-09-24 2010-02-02 Anticancer vaccine and diagnostic methods and reagents

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32445001P 2001-09-24 2001-09-24
US60/324,450 2001-09-24

Publications (2)

Publication Number Publication Date
WO2003033520A2 WO2003033520A2 (en) 2003-04-24
WO2003033520A3 true WO2003033520A3 (en) 2004-02-19

Family

ID=23263637

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/030289 WO2003033520A2 (en) 2001-09-24 2002-09-24 Anticancer vaccine and diganostic methods and reagents

Country Status (4)

Country Link
US (3) US20030143647A1 (en)
EP (1) EP1435776A4 (en)
AU (1) AU2002361559A1 (en)
WO (1) WO2003033520A2 (en)

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US20050230315A1 (en) * 2003-01-13 2005-10-20 Regents Of The University Of Michigan Protein microarray system
US20030064527A1 (en) * 2001-02-07 2003-04-03 The Regents Of The University Of Michigan Proteomic differential display
US20080096284A1 (en) * 2000-02-08 2008-04-24 Regents Of The University Of Michigan Protein separation and analysis
AU2001234893A1 (en) * 2000-02-08 2001-08-20 The Regents Of The University Of Michigan Protein mapping
US20080153711A1 (en) * 2000-02-08 2008-06-26 Regents Of The University Of Michigan Protein microarray system
US6931325B2 (en) 2001-02-07 2005-08-16 Regents Of The University Of Michigan Three dimensional protein mapping
EP1435776A4 (en) * 2001-09-24 2006-01-25 Univ Pittsburgh Anticancer vaccine and diganostic methods and reagents
ATE405592T1 (en) * 2003-01-13 2008-09-15 Univ Michigan METHOD FOR FORMING A PROTEIN MICROARRAY SYSTEM
ES2247922A1 (en) * 2004-05-07 2006-03-01 Gianluca Cornetta Integrated event management system using radio frequency for use in e.g. hotels, has central server with corresponding database that communicates with portable and remote terminals and with other peripheral devices using radio frequency
WO2007044033A2 (en) 2004-12-07 2007-04-19 University Of Pittsburgh Of The Commonwealth System Of Higher Education Therapeutic and diagnostic cloned mhc-unrestricted receptor specific for the muc1 tumor associated antigen
EP1864996A1 (en) * 2006-06-06 2007-12-12 Helmholtz-Zentrum für Infektionsforschung GmbH Peptide associated with rheumatic fever (PARF) and its use as a diagnostic marker.
WO2010011994A2 (en) 2008-07-25 2010-01-28 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Polypeptides and uses thereof
JP6368243B2 (en) * 2011-11-11 2018-08-08 フレッド ハッチンソン キャンサー リサーチ センター T-cell immunotherapy targeted to cyclin A1 for cancer
FR3008099B1 (en) 2013-07-05 2020-08-07 Commissariat Energie Atomique TUMOR ANTIGEN CYCLINE B1 IMMUNOGEN PEPTIDES
US10023841B2 (en) * 2014-05-23 2018-07-17 Baylor Research Institute Methods and compositions for treating breast cancer with dendritic cell vaccines
KR20180040706A (en) * 2015-09-01 2018-04-20 인네이트 튜머 이뮤니티, 인코포레이티드 Immune cells having increased immunity or resistance to immunosuppressive cytokines and uses thereof
EP4239653A1 (en) 2017-02-01 2023-09-06 Horton, Inc. Electromagnetic coil connection assembly and associated method
FR3090319A1 (en) 2018-12-21 2020-06-26 Commissariat A L'energie Atomique Et Aux Energies Alternatives MIXTURES OF CD8 T + EPITOPE CYCLINE B1 IMMUNOGENS

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Also Published As

Publication number Publication date
US20030143647A1 (en) 2003-07-31
EP1435776A2 (en) 2004-07-14
US7704507B2 (en) 2010-04-27
US20100297158A1 (en) 2010-11-25
AU2002361559A1 (en) 2003-04-28
EP1435776A4 (en) 2006-01-25
US8211436B2 (en) 2012-07-03
WO2003033520A2 (en) 2003-04-24
US20060147460A1 (en) 2006-07-06

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