WO2002059584A3 - Scanning spectrophotometer for high throughput fluorescence detection - Google Patents
Scanning spectrophotometer for high throughput fluorescence detection Download PDFInfo
- Publication number
- WO2002059584A3 WO2002059584A3 PCT/US2001/050136 US0150136W WO02059584A3 WO 2002059584 A3 WO2002059584 A3 WO 2002059584A3 US 0150136 W US0150136 W US 0150136W WO 02059584 A3 WO02059584 A3 WO 02059584A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- excitation
- emission
- samples
- high throughput
- fluorescence detection
- Prior art date
Links
- 238000001917 fluorescence detection Methods 0.000 title 1
- 230000005284 excitation Effects 0.000 abstract 4
- 238000001514 detection method Methods 0.000 abstract 1
- 238000002875 fluorescence polarization Methods 0.000 abstract 1
- 239000007850 fluorescent dye Substances 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6445—Measuring fluorescence polarisation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/02—Details
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/02—Details
- G01J3/0205—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows
- G01J3/0216—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows using light concentrators or collectors or condensers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/02—Details
- G01J3/0205—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows
- G01J3/0224—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows using polarising or depolarising elements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/02—Details
- G01J3/0205—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows
- G01J3/0229—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows using masks, aperture plates, spatial light modulators or spatial filters, e.g. reflective filters
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/02—Details
- G01J3/0205—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows
- G01J3/0235—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows using means for replacing an element by another, for replacing a filter or a grating
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/02—Details
- G01J3/06—Scanning arrangements arrangements for order-selection
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/12—Generating the spectrum; Monochromators
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/12—Generating the spectrum; Monochromators
- G01J3/18—Generating the spectrum; Monochromators using diffraction elements, e.g. grating
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/28—Investigating the spectrum
- G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
- G01J3/4406—Fluorescence spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/12—Generating the spectrum; Monochromators
- G01J2003/1213—Filters in general, e.g. dichroic, band
- G01J2003/1217—Indexed discrete filters or choppers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N2021/6417—Spectrofluorimetric devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N2021/6417—Spectrofluorimetric devices
- G01N2021/6421—Measuring at two or more wavelengths
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N2021/6463—Optics
Abstract
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01994417A EP1352230A2 (en) | 2000-12-29 | 2001-12-31 | Scanning spectrophotometer for high throughput fluorescence detection |
JP2002559651A JP2005500513A (en) | 2000-12-29 | 2001-12-31 | Scanning spectrophotometer for high-throughput fluorescence detection |
CA002432210A CA2432210A1 (en) | 2000-12-29 | 2001-12-31 | Scanning spectrophotometer for high throughput fluorescence detection |
AU2002246811A AU2002246811A1 (en) | 2000-12-29 | 2001-12-31 | Scanning spectrophotometer for high throughput fluorescence detection |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25932600P | 2000-12-29 | 2000-12-29 | |
US60/259,326 | 2000-12-29 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002059584A2 WO2002059584A2 (en) | 2002-08-01 |
WO2002059584A3 true WO2002059584A3 (en) | 2003-01-30 |
Family
ID=22984477
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/050136 WO2002059584A2 (en) | 2000-12-29 | 2001-12-31 | Scanning spectrophotometer for high throughput fluorescence detection |
Country Status (6)
Country | Link |
---|---|
US (2) | US7352459B2 (en) |
EP (1) | EP1352230A2 (en) |
JP (1) | JP2005500513A (en) |
AU (1) | AU2002246811A1 (en) |
CA (1) | CA2432210A1 (en) |
WO (1) | WO2002059584A2 (en) |
Families Citing this family (40)
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GB9821989D0 (en) * | 1998-10-08 | 1998-12-02 | Hybaid Ltd | Detection of nucleic acid polymorphism |
US6654119B1 (en) * | 1999-04-21 | 2003-11-25 | Chromagen, Inc. | Scanning spectrophotometer for high throughput fluroescence detection |
DE10136863A1 (en) * | 2001-07-28 | 2003-02-20 | Berthold Tech Gmbh & Co Kg | Device for the optional measurement of in particular luminescence and / or fluorescence radiation |
WO2003062824A1 (en) * | 2002-01-23 | 2003-07-31 | Boditech Inc. | Lateral flow quantitative assay method and strip and laser-induced fluoerescence detection device therefor |
US8227256B2 (en) * | 2002-09-27 | 2012-07-24 | Saloma Caesar A | Two-color (two-photon) excitation with focused excitation beams and a raman shifter |
AU2003900902A0 (en) * | 2003-02-27 | 2003-03-13 | Varian Australia Pty Ltd | Spectrophotometer |
JP2005121479A (en) * | 2003-10-16 | 2005-05-12 | Tokyo Instruments Inc | Confocal microscopic spectroscope |
US7304735B2 (en) * | 2004-04-02 | 2007-12-04 | Kla-Tencor Technologies | Broadband wavelength selective filter |
DE102004031049A1 (en) * | 2004-06-25 | 2006-01-12 | Leica Microsystems Cms Gmbh | Optical arrangement for spectrally selective detection of light of a light beam |
US7221449B2 (en) | 2004-06-28 | 2007-05-22 | Applera Corporation | Apparatus for assaying fluorophores in a biological sample |
US7576311B2 (en) * | 2005-09-13 | 2009-08-18 | Lockheed Martin Corporation | Optical detector having a sensing element, a lens and a frustum coupled to the lens |
JP5507248B2 (en) | 2006-08-28 | 2014-05-28 | サーモ エレクトロン サイエンティフィック インストルメンツ リミテッド ライアビリティ カンパニー | Spectrometer with reduced vignetting |
US7984454B2 (en) * | 2006-12-19 | 2011-07-19 | International Business Machines Corporation | Migration of single root stateless virtual functions |
US9557217B2 (en) | 2007-02-13 | 2017-01-31 | Bti Holdings, Inc. | Universal multidetection system for microplates |
US7782454B2 (en) * | 2007-02-13 | 2010-08-24 | Bti Holdings, Inc. | Universal multidetection system for microplates |
CN103495439B (en) | 2007-05-04 | 2015-09-16 | 欧普科诊断有限责任公司 | Fluid connector and microfluid system |
US9006684B2 (en) | 2007-10-31 | 2015-04-14 | Perkinelmer Singapore Pte. Ltd. | Sample measurement system |
DE202008009859U1 (en) * | 2007-12-21 | 2009-03-05 | Berthold Technologies Gmbh & Co. Kg | Device for the optional measurement of in particular luminescence and / or fluorescence radiation |
EP2223431A4 (en) | 2008-08-15 | 2010-09-01 | Lsi Corp | Ram list-decoding of near codewords |
JP2010112809A (en) * | 2008-11-06 | 2010-05-20 | Shimadzu Corp | Spectral fluorescence photometer |
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NL2004199C2 (en) * | 2010-02-05 | 2011-08-08 | Stichting Noble House | A VEHICLE EQUIPPED WITH A DEVICE FOR DETECTING EXTERNAL LASER MEASURING EQUIPMENT AND METHOD FOR FITTING SUCH DEVICE. |
US8504900B2 (en) | 2010-07-02 | 2013-08-06 | Lsi Corporation | On-line discovery and filtering of trapping sets |
JP5937780B2 (en) * | 2010-11-11 | 2016-06-22 | ソニー株式会社 | Fluorescence spectrum correction method and fluorescence spectrum measuring apparatus |
US8913240B2 (en) * | 2011-09-30 | 2014-12-16 | Shimadzu Corporation | Fluorescence spectrophotometer |
US8768990B2 (en) | 2011-11-11 | 2014-07-01 | Lsi Corporation | Reconfigurable cyclic shifter arrangement |
US9672329B2 (en) | 2012-03-05 | 2017-06-06 | Opko Diagnostics, Llc | Methods and apparatuses for predicting risk of prostate cancer and prostate gland volume |
US8686364B1 (en) * | 2012-09-17 | 2014-04-01 | Jp3 Measurement, Llc | Method and system for determining energy content and detecting contaminants in a fluid stream |
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JP6801846B2 (en) * | 2013-02-05 | 2020-12-16 | マサチューセッツ インスティテュート オブ テクノロジー | 3D holographic imaging flow cytometry |
CN105784675B (en) * | 2015-01-13 | 2020-01-07 | 爱科来株式会社 | Plasma spectroscopic analysis method and plasma spectroscopic analysis apparatus |
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WO2017169083A1 (en) * | 2016-03-31 | 2017-10-05 | 富士フイルム株式会社 | Imaging device and imaging method |
US10082466B2 (en) * | 2016-04-26 | 2018-09-25 | Molecular Devices, Llc | Methods and systems for optical-based measurement with selectable excitation light paths |
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EP3299780A1 (en) * | 2016-09-26 | 2018-03-28 | Berthold Technologies GmbH & Co. KG | Method and system for spectroscopic measurement of optical properties of samples |
US10386232B2 (en) | 2017-12-15 | 2019-08-20 | Horiba Instruments Incorporated | Compact spectroscopic optical instrument |
CN108181284A (en) * | 2018-01-19 | 2018-06-19 | 杭州安誉科技有限公司 | A kind of data acquisition device of real-time fluorescence quantitative PCR instrument |
US20200340858A1 (en) * | 2019-04-24 | 2020-10-29 | Applied Materials, Inc. | Plasma emission monitoring system with cross-dispersion grating |
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DE2628551A1 (en) * | 1976-06-25 | 1977-12-29 | Rolf Dietrich | Microscope photometer double beam analysis appts. - has chopper and comparator mirror between specimen and detector |
GB2119507A (en) * | 1982-04-10 | 1983-11-16 | Bruker Analytische Messtechnik | Infrared spectrometer |
WO2000063680A1 (en) * | 1999-04-21 | 2000-10-26 | Chromagen | A novel scanning spectrophotometer for high throughput fluorescence detection |
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US5978110A (en) * | 1996-06-07 | 1999-11-02 | The Regents Of The University Of California | Holographic optical grating and method for optimizing monochromator configuration |
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-
2001
- 2001-12-31 AU AU2002246811A patent/AU2002246811A1/en not_active Abandoned
- 2001-12-31 US US10/039,769 patent/US7352459B2/en not_active Expired - Fee Related
- 2001-12-31 CA CA002432210A patent/CA2432210A1/en not_active Abandoned
- 2001-12-31 WO PCT/US2001/050136 patent/WO2002059584A2/en active Application Filing
- 2001-12-31 JP JP2002559651A patent/JP2005500513A/en not_active Withdrawn
- 2001-12-31 EP EP01994417A patent/EP1352230A2/en not_active Withdrawn
-
2008
- 2008-03-31 US US12/060,170 patent/US20080225289A1/en not_active Abandoned
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2628551A1 (en) * | 1976-06-25 | 1977-12-29 | Rolf Dietrich | Microscope photometer double beam analysis appts. - has chopper and comparator mirror between specimen and detector |
GB2119507A (en) * | 1982-04-10 | 1983-11-16 | Bruker Analytische Messtechnik | Infrared spectrometer |
WO2000063680A1 (en) * | 1999-04-21 | 2000-10-26 | Chromagen | A novel scanning spectrophotometer for high throughput fluorescence detection |
Also Published As
Publication number | Publication date |
---|---|
US7352459B2 (en) | 2008-04-01 |
US20080225289A1 (en) | 2008-09-18 |
JP2005500513A (en) | 2005-01-06 |
US20020109841A1 (en) | 2002-08-15 |
AU2002246811A1 (en) | 2002-08-06 |
EP1352230A2 (en) | 2003-10-15 |
CA2432210A1 (en) | 2002-08-01 |
WO2002059584A2 (en) | 2002-08-01 |
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