WO2000054735A1

WO2000054735A1 - Method for producing cosmetic or pharmaceutical formulations by means of a micromixture directly before use

Info

Publication number: WO2000054735A1
Application number: PCT/EP2000/001974
Authority: WO
Inventors: Jutta Zur Lage; Hans-Jürgen DRILLER; Joachim BÜNGER; Annette Wagner
Original assignee: Merck Patent Gmbh
Priority date: 1999-03-17
Filing date: 2000-03-07
Publication date: 2000-09-21
Also published as: AU768399B2; EP1161221A1; JP2002538947A; AU3961100A; CA2367391A1; DE19911777A1; CN1344145A

Abstract

The present invention relates to a method for producing cosmetic or pharmaceutical formulations directly before use. Two or more liquid components from separate storage chambers are intimately mixed together by feeding the liquid components through a micromixer. The invention also relates to the lotions, emulsions, gels, cremes and solutions for cosmetic use or, provided that corresponding pharmaceutical active substances are incorporated, for the produced pharmaceutical formulations, whereby the lotions, emulsions, gels, cremes and solutions are produced by the inventive method.

Description

METHOD FOR PRODUCING COSMIC OR PHARMACEUTICAL FORMULATIONS BY MICROMIXING DIRECTLY BEFORE USE

The present invention relates to a method for producing cosmetic or pharmaceutical formulations immediately before use, two or more liquid components from separate storage chambers being intimately mixed with one another by passing the liquid components through a micromixer. Furthermore, the present invention also relates to the lotions, emulsions, gels, creams and solutions produced by the process according to the invention, either for cosmetic use or, if appropriate pharmaceutical active ingredients have been incorporated, the pharmaceutical formulations prepared.

Various processes are used to manufacture cosmetic products, to mix several substances as intimately as possible. Depending on the required mixing intensity, one or more methods of combining substances are used, which can take place in succession or in parallel.

In chemical process engineering, mixing is to be understood as basic operations which serve the greatest possible homogenization of substances. Material flows should be combined in such a way that the individual components are composed as evenly as possible in partial volumes of the resulting mixture.

Homogenization is a special form of mixing. This is understood to mean mixing phases that are not miscible with one another. Homogenization is understood to mean changing the distribution state and particle size of the inner phase of emulsions and suspensions, so that microscopically, a homogeneous system is created and the distributed phase does not settle or cream without the action of external forces.

Dispersing is understood to mean a mixing of a material system consisting of two (or more) phases, in which one substance (disperse phases) is mixed in another (dispersion medium) in the finest form. divides (disperses). Both the particles of the disperse phase and the dispersant can be solid, liquid or gaseous. Examples of dispersions are aerosols, emulsions, suspensions and colloids.

Another type of mixing that is common in cosmetics production is emulsification. This is understood to mean mixing two liquids which are insoluble or only slightly soluble in one another, one of which is finely distributed in the other. The outer phase is referred to as the continuous phase or as a dispersant, the liquid distributed therein as the inner, discontinuous or disperse phase. Cosmetic emulsions mostly consist of an aqueous polar phase and a non-polar oil phase.

Suspending in turn means the distribution of very small, but not molecular, particles of a solid in a liquid. Suspensions, like emulsions, are usually optically cloudy and tend to settle under the influence of gravity.

Emulsification processes are usually carried out according to the following scheme: Two substances that are insoluble in each other, namely fat and water, are mixed. In order to obtain a durable emulsion, the fat and water phases have to be mechanically crushed to below 10 μm and then stabilized with the help of an emulsifier. Normally, the oil and fat phases are introduced separately, heated to 50 - 70 ° C and then pre-emulsified. All water-soluble substances are in the water phase, all fat-soluble substances in the fat phase.

The pre-emulsion produced after the hot / hot process (both phases are heated separately to 50-70 ° C) is cooled to room temperature before the addition of perfume oil and dye and then emulsified.

In some cases of emulsion production, a water phase at 20-30 ° C can be assumed. In this hot / cold process, there is no need to cool before the perfume oil and dye are added. If the fat phase is a thin oil at room temperature, both phases can be at a temperature of 20-30 ° C submitted and emulsified (cold / cold process). (from: W. Umbach, "Cosmetics", Georg Thieme Verlag, Stuttgart 1995)

In the manufacture of emulsions, suspensions and dispersions which are delivered to the end user, it is desirable to obtain stable products over a longer period of time which do not tend to separate and at the same time in which the added active ingredients retain their activity. The stability of the mixtures is in conventional products by the addition of additives such. B. emulsifiers, tensi

I Q achieved the or the like. In order to prevent decomposition of the ingredients and to prevent a decrease in the activity of active ingredients contained, z. B. Added oxidation stabilizers, radical scavengers, bactericides and other additives. Various of these additives can cause irritation or allergies in sensitive users

₁₅ lead.

In many cases, therefore, it is not the active ingredient itself that is used to stabilize active ingredients, but one of its more stable derivatives, which then decomposes at the site of action and releases the active ingredient. This is of course fraught with the problem that if

If necessary transport or metabolic processes occur, the derivative behaves differently than the actual active ingredient.

Another problem in the production of the mixtures listed above is the homogeneous mixing of the individual substances in each volume element of the entire mixture.

Simple mixing vessels with different types of stirrers are often used to produce cosmetic formulations. Depending on the type of stirrer (e.g. anchor, propeller, inclined blade, disc, EKATO-MIG stirrer, EKATO-Mizer disc) in the mixing vessels depending on the location

30 mixing vessel with different shear forces. The same applies to the temperature distribution and the energy input into the formulation, so that shear forces, temperature and introduced energy are not “evenly” distributed in the preparation vessel and so the structure of the resulting formulation is adversely affected. Specifically, this means that, for example

35 emulsions can arise in which the emulsified phase is very has different particle sizes, or the active ingredient distribution in a manufactured product is uneven.

It is therefore an object of the present invention to provide a process whereby mixed products are obtained which have a homogeneous distribution of all the components contained in the entire mixture and at the same time a homogeneous distribution of the particle or droplet size. Furthermore, it is an object of the invention to provide a process for the production of cosmetic or pharmaceutical formulations, as a result of which the use of emulsifiers, surfactants, stabilizers, oxidation stabilizers, radical scavengers, bactericides and other additives can be restricted, or ideally, to their use can be dispensed with entirely. It is also an object of the invention to provide a process by which cosmetic or pharmaceutical formulations can only be produced in very small quantities immediately before they are used.

The object of the invention is achieved by a process for the production of cosmetic or pharmaceutical formulations immediately before use, characterized in that two or more liquid components from separate storage chambers are mixed with one another by being passed through a micromixer.

To carry out the method according to the invention, two or more components, optionally after heating, can be passed in liquid form for mixing through a micromixer from separate storage chambers.

Mixing can be carried out by passing the components from separate storage chambers, if necessary after heating, in liquid form through a temperature-controlled micromixer and stirring them if necessary to cool them down.

The implementation of the process for the production of cosmetic or pharmaceutical formulations in the form of emulsions immediately Before use, one or more liquid component (s) with one or more natural, synthetic or semi-synthetic oil (s) can be passed from separate storage chambers through a micromixer, mixing them together.

The object of the invention is also achieved by a process for the production of cosmetic formulations in the form of emulsions immediately before use, characterized in that a fat phase consisting of one or more natural, synthetic or semisynthetic oil (s) and one or more of Fat (s) which are solid at room temperature are liquefied in a storage chamber by heating, and this liquid fat phase is mixed with one or more liquid component (s) and optionally with another oil phase by passing them through a micromixer.

In a special embodiment of the method according to the invention, the components to be mixed are pumped out of the storage chambers and are passed into the micromixer through subsequent thin tubes, which each end in a channel of a micromixer, and through the channels of the pump due to the pressure building up as a result of the pumping Micromixer are pressed with intensive mixing and formation of an emulsion.

According to the invention, it is also possible to convey the components to be mixed from pressurized storage chambers through subsequent thin tubes, which each end in a channel of a micromixer, to guide the components into the micromixer and through the channels of the micromixer due to the build-up Pressure with intensive mixing and formation of an emulsion.

The object of the invention is further achieved by a process for the preparation of liposome-containing formulations immediately before use, by one or more liquid component ^) with a component which contains liposome-forming ingredients O 00/54735 - 6 - PCT / EPOO / 01974

contains, are mixed together from separate storage chambers by passing them through a micromixer to form the desired liposomes. This can take place after one or more of the component (s) to be mixed has been heated before the formulation is prepared. This method can be carried out in such a way that the components to be mixed are pumped out of the storage chambers and are passed into the micromixer through the subsequent thin tubes, which each end in a channel of a micromixer, and because of the pressure built up by the pumping the channels of the micromixers are pressed with intensive mixing and formation of a liposome-helpful formulation.

In particular, the components to be mixed can be conveyed from pressurized storage chambers and passed into the micromixer through adjoining thin tubes, which each end in a channel of a micromixer. Due to the pressure coming from the storage chambers, a sufficient pressure is built up in the micromixer, by means of which the components are pressed through the channels with intensive mixing and formation of a liposome-helpful formulation.

The present object is also achieved by means of lotions or solutions, emulsions, gels and creams which can be produced by the process according to the invention.

For certain formulations, uniform mixing, a constant temperature and even energy input in the micro range is important. It has now been found that the use of micromixers

Production of mixtures in the form of emulsions, suspensions and dispersions, lotions, solutions, gels and creams is possible, in which all ingredients are evenly distributed in the smallest parts by volume. In contrast to a large-volume stirred kettle, these mixtures can also be produced in the micro range under uniform temperature conditions, since the thin, possibly laminate-like no temperature drop forms, especially if the micromixer is designed for temperature control. Furthermore, the energy input is the same in every, ie even in the smallest part of the volume. It has also been found that emulsions can be produced with a much more homogeneous droplet size distribution than in a stirred vessel. Due to the multiple shear conditions of the communicating channels in the micromixer, droplet sizes in the micro range are inevitable, so that microemulsions are obtained which could only be produced in a stirred vessel in a very complex manner. The use of a micromixer is therefore suitable for the production of very fine, homogeneous formulations.

Micromixers, associated connection and closure systems are suitable for carrying out the method according to the invention, which are described in patent applications DE 1 95 11 603, DE 1 97 46 583, DE 1 97 46 584,

DE 19746585 and DE 1 98 54 096 are described, as well as the embodiments resulting therefrom. Suitable micromixers can consist of suitable metallic, ceramic, polymeric materials or silicon.

Problematic formulations in the W / O field are emulsions, in particular those with high levels of vegetable triglycerides. Emulsions without stabilizing waxes are often characterized by insufficient long-term viscosity constancy and OW lotions are generally more difficult to stabilize than creams. These emulsions can therefore be produced particularly well using micromixers. It is particularly advantageous here that particularly small quantities can be produced by using micromixers, which advantageously in situ, i. H. can be made directly before use.

Microemulsions are thermodynamically stable if they arise spontaneously due to extremely low interfacial energy, that is, without the addition of external mechanical energy. The droplet diameters are much smaller than with macroemulsions, they are in the range of 10-30 nm (nanometers), which means below the wavelength of visible light. Microemulsions are therefore colloidally disperse, optical transparent systems. According to POHLER, certain concentration ranges of the oil and water phases as well as the emulsifiers and auxiliary substances must be observed when formulating microemulsions:

Surfactants (mostly non-ionic surfactants) 15 - 40%

Mineral oil or vegetable oil 5 - 25%

Polyalcohols 0 - 20%

Water 35 - 65%

The use of micromixers for the production of microemulsions makes it possible to considerably reduce the use of surfactants, so that the tolerance for particularly sensitive skin types can be significantly increased. Stable microemulsions can be produced using less than 10% by weight of surfactants.

Usually, the most important requirements for emulsifying devices are sufficient and in particular variable emulsifying performance, sufficient shear or. Impact and impact forces, equipment for uniform processing of the attachment, vacuum device, heating and cooling (14). According to the invention, these problems can be solved in a simple manner by using suitable micromixers which ensure targeted energy input in each volume element and in which intensive mixing takes place in the thin channels under the action of intensive shear forces.

Furthermore, the use of micromixers makes it possible to produce very small amounts of the desired cosmetic or pharmaceutical formulations immediately before use. This has the advantage that the addition of emulsifiers, suspension and dispersion aids in the form of surfactants and other additives such as. B. stabilizers can be very limited or their use can be omitted entirely. In this way it is also possible to mix active ingredients or additives which are not compatible with one another in a formulation for a long time only immediately before use. Active ingredients that are only stable in the form of a derivative in a formulation, can be presented as such in a separate formulation and added directly before the rest of the mixture is used. The user can also add different additives to small quantities of a base mixture at different times, as required. This can be of interest for both pharmaceutical and cosmetic formulations if different active ingredients are to be applied at different times.

Other additives can be added to a basic cosmetic formulation for the day than for the night. Additives for the day can be UV filters, for example, while regenerative additives for the night.

Examples are given below to illustrate and better understand the present invention. However, due to the general validity of the principle of the invention described, these are not suitable for reducing the scope of protection of the present application only to these examples. Furthermore, the content of the cited patent applications is to be regarded as part of the disclosure of the present invention and the present description.

example 1

Hand and nail cream

Raw material INCI% W / W

A Paraffin (1) Mineral Oil 2.00

(Item no.107162)

Arlamol HD (2) isohexadecane 2.00

Isopropyl palmitate (3) Isopropyl palmitate 3.00

Soybean Oil (4) Glycine Soybean 0.50

Mirasil DM 350 (5) Dimethicone 1, 00

La nice O (3) Cetearyl Alcohol 1.00

Span 60 (2) Sorbitan Stearate 1, 50

Montanov 68 (6) Cetearyl Alcohol (and) Cetearyl Glucoside 4.00

(-) - (α-bisabolol (1) bisabolol 0.30

(Art.No. 130170) B Demin. Water aqua ad 100

Glycerin, 87% (D glycerin 10.00

(Item no.104091)

D-panthenol (7) panthenol 0.50

(D +) - biotin d) biotin 0.05

(Item no.130220)

(if necessary) preservatives q.s.

C Rhodicare S (5) xanthan gum 0.30

Possibly:

D Bianca perfume (8) 0.20 perfume

Manufacturing:

Phases A, B and C are each placed separately in a storage container and heated to 75 ° C. The thus liquid phases B and C are pumped out of the storage containers and passed through a micromixer heated to 75 ° C. and mixed. The mixture emerging from the micromixer is then pumped with phase A through a micromixer heated to 75 ° C. and homogenized. The emulsion obtained is in a

Storage container collected and cooled with stirring. At a temperature of approx. 35 ° C the perfume can be added if necessary.

Remarks:

_P H ₂₅ ° C value: 5.5

Viscosity: 43000 mPa.s (Brookfield RVT, spindle C, 5 rpm, Helipath) at 25 ° C 0.05% propyl 4-hydroxybenzoate (Merck KGaA, item no.130173), 0.15% methyl 4- hydroxybenzoate (Merck KGaA, Art. No. 13 0174), 0.30% Germall 115 (ISP, Frechen)

Sources of supply:

(1) Merck KGaA, Darmstadt

(2) ICI Surfactants, Essen

(3) Henkel KGaA, Düsseldorf

(4) Gustav Hees, Stuttgart

(5) Rhodia, Frankfurt (6) Seppic, France

(7) BASF, Ludwigshafen

(8) H&R, Holzminden

Example 2

W / 0 body care milk (KALT-HEI STELLUN

A. ARLACEL 780 5.0%

Paraffin oil thin 10.0%

Miglyol 812 4.0%

ARLAMOL HD 5 0%

ARLAMOL E 1.0%

Perfume (possibly) q.s.

B. Glycerin 2.5%

ATLAS G-2330 1.5%

Mg S0 ₄ 0.5%

Demin. Water 70.5%

Preservation (possibly) q.s.

Manufacturing method:

Both phases A and B are placed separately in a storage container. After mixing, which can be done either by stirring or by shaking in small vessels, the phases are pumped out of the storage containers and passed together through a micromixer, in which the phases are mixed intensively. The homogeneously mixed milk can be used directly.

Viscosity:

10,000 mPa s (Brookfield LVT Helipath, spindle C, 6 rpm, 1 min.)

Sources of supply:

(1) ICI surfactants

Example 3

Sun protection milk (W / S) (water in silicone) A Eusolex 2292 (Art.No. 5382) (D 2.00

DC 1401 (2) 10.00

DC 3225 C (2) 10.00

Dow Coming 344 (2) 10.00 q.s.

B Eusolex 232 (Item No. 5372) (1) 2.00

Tris (hydroxymethyl) - (1) 0.88 aminomethane (Item No. 8386)

Sodium chloride (Item No. 6400) (1) 2.00

Glycerin (Item No. 4093) (1) 5.00

Preservatives (possibly) q.s.

Water, demineralized ad 100.00

Manufacturing:

To produce phase B, tris (hydroxymethyl) aminomethane is dissolved in water in a storage vessel to neutralize Eusolex 232 and Eusolex 232 is added. After the solution has been completely dissolved, the remaining phase B raw materials are added. The components of phase A are premixed in a second storage vessel.

To produce the sun protection milk, the two mixing phases are pumped together with the help of a pump through a micromixer connected via thin connecting tubes.

Remarks

Viscosity 22,800 mPas (Brookfield RVT, Sp. C, 10 rpm) at 25 'C samples contain 0.05% propyl 4-hydroxybenzoate as a preservative (Merck item no. 7427)

0.17% methyl 4-hydroxybenzoate sodium salt (Merck Art.No. 6756)

Reference sources:

(1) E. Merck, Darmstadt

(2) Dow Corning, Düsseldorf Example 4

Transparent microemulsion

Trade name INCI% by weight

Eumulgin B2 Ceteareth-20 19.5

Cetiol RE PEG-7 Glyceryl Cocoate 20.0

Uniphen P-23 phenoxyethanol + methyl- /

Ethyl / propyl / butyl paraben 0.3

Mineral oil 5.0

Glycerin Glycerin 20.0

Water, demin. Water 35.2

Manufacturing:

1. Eumulgin B2, Cetiol HE, Uniphen P-23 and the paraffin oil are placed in a storage vessel, melted while mixing and heated to approx. 95 ° C-105 ° C.

2. Water and the glycerin are combined and also heated to approx. 95 ° C-100 ° C. Increase the amount of water by 3%.

3. The water phase and the fat phase are pumped through a micromixer for intensive mixing. The resulting microemulsion gel was stirred to cool.

Alternatively, it is possible to pass the microemulsion gel through a further cooled micromixer, the outgoing channels of which have a further cross section, as a result of which the channels are not clogged and the formation of air pockets in the gel is prevented.

At a temperature at which the microemulsion gel is just pourable, it is filled into the primary packaging. Example 5

Sun protection gel (emulsifier-free)

SPF 3.21 UVA PF 2.5 (Sun protection factor, Diffey method)

% By weight

A Eusolex 2292 (Art.No. 105382) (1) 1,000

Luvitol EHO (2) 9,000

Dow Corning 200 (100 es) (3) 2,000 Antaron V-220 (4) 2,000

Jojoba Oil (5) 5,000

DL-α-tocopherol acetate (1) 0.500 (Art. No. 500952)

B tris (hydroxymethyl) aminomethane (1) 0.700

(Art.no.108386) Water, demineralized 14.300

C Pemulen TR-1 (6) 0.600

Preservative (possibly) (1) q.s.

Water, demineralized ad 100, 000

D Aloe Vera Gel 1:10 (7) 1,000

Manufacturing:

For phase C, disperse the Pemulen TR-1 homogeneously in the water, add the preservative and swell. Enter phase B under homogenization in phase C. Dissolve phase A while heating and add slowly while homogenizing. Add phase D at 35 ° C and homogenize again.

Remarks:

Viscosity 67,000 mPas (Brookfield RVT, Sp. C, 5 rpm) at 25 ° C

PH ₂₅ ° _C = 6.9 As a preservative, 1.0% phenoxyethanol (Merck item no. 807291) can be added. Reference sources

(1) Merck KGaA, Darmstadt (2) BASF, Ludwigshafen

(3) Dow Corning, Düsseldorf (4) GAF, Frechen

(5) Henry Lamotte, Bremen (6) Goodrich, Neuss

(7) Rahn, Maintal

Example 6

In situ W / O / W super moisturizing cream

Composition:

W / W

'Brij 721 2.0

Brij 72 3.0

Arlacel P135 0.5

Arlamol E 5.0

Arlamol HD 4.0

Vitamin E acetate 1.0

Laurex CS 1.0

Stearic acid 1.5

Mirasil DM 100 1.0

B

1, 2-propylene glycol 4.0

Allantoin 0.2

Urea 0.5

Water 74.4

Germaben II 1.0

D. (if applicable) Perfume L94-5770 0.1

Manufacturing:

1. A and B are heated to a temperature of 75 ° C. in separate storage containers.

2. Before the emulsion is made, C is added to B.

3. Phases A and B / C are mixed intensively by pumping them through a micromixer heated to 75 ° C.

4. The resulting emulsion is collected in a storage vessel.

5. If necessary, D is added after cooling to a temperature below 35 ° C.

6. Further cooling to room temperature is carried out with gentle stirring.

Remarks:

Viscosity 43,000 mPa.s (Brookfield LVT T-bar spindle, E, rpm 6, 1 min.)

Example 7

W / O / W face moisturizer (two-stage production)

Composition:

Primary emulsion W / O

% W / W

ArlaceM MO 3.3

Arlacel 2064 3.0

Arlamol HD 15.0

Arlamol ^' M812 14.0

B water 63.7 Germaben II 1.0 Secondary emulsion W / O / W

A. Primary emulsion W / O 50.0

B. 'Arlatone 2121 5.0 Water 44.1

Keltrol 0.4

C. Germaben II 0.5

Manufacturing:

Primary emulsion W / O

1. Slowly add B to A with vigorous stirring.

2. The mixture obtained is homogenized for a further 5 minutes.

Secondary emulsion W / O / W

1. The composition specified under B is heated to a temperature of 80 ° C. with the exception of Keltrol. Keltrol is dispersed with stirring at constant temperature in the submitted composition.

The two separately prepared compositions A and B are mixed in a micromixer as described above.

2. C is added to the emulsion, which has cooled to a temperature below 40 ° C.

3 .. Cool to room temperature with gentle stirring.

Remarks::

Viscosity 16,000 mPa.s (Brookfield LVT, T-) spindle D, rpm 6, min.)

Claims

PATENT CLAIMS

1. Process for the production of cosmetic or pharmaceutical formulations immediately before use, characterized in that two or more liquid components from separate

Pantry chambers are mixed together by passing them through a micromixer.

2. Process for the production of cosmetic formulations characterized in that two or more

Components from separate storage chambers, if necessary after heating, are passed through a micromixer in liquid form for mixing.

3. The method according to claims 1 to 2, characterized in that two or more components from separate storage chambers, optionally after heating, are passed in liquid form for mixing through a temperature-controlled micromixer and are subsequently stirred.

4. Process for the production of cosmetic formulations in the form of emulsions immediately before use, characterized in that one or more liquid components are mixed with one or more natural, synthetic or semi-synthetic oils from separate storage chambers by they are passed through a micromixer.

5. Process for the production of cosmetic formulations in the form of emulsions immediately before use, characterized in that a fat phase consisting of one or more natural, synthetic or semi-synthetic oil (s) and one or more fat (s) solid at room temperature ), is liquefied in a storage chamber by heating, and this liquid fat phase is mixed with one or more liquid components and optionally with a further oil phase by passing them through a micromixer.

6. The method according to claims 1 to 5, characterized in that the components to be mixed are pumped from the storage chambers and passed through adjoining thin tubes, each of which ends in a channel of a micromixer, into the micromixer and due to the pumping Building pressure is pushed through the channels of the micromixer with intensive mixing and formation of an emulsion.

7. The method according to claims 1, 4 to 6, characterized in that the components to be mixed are pumped from the pressurized storage chambers, passed through adjoining thin tubes, each of which ends in a channel of a micromixer, into the micromixer and due to The pressure that builds up during pumping is pushed through the channels of the micromixer with intensive mixing and the formation of an emulsion.

8. Process for the production of liposome-containing formulations immediately before use, characterized in that one or more liquid components are mixed with a component which contains liposome-forming ingredients from separate storage chambers by passing them through a micromixer to form of the desired liposomes.

9. A process for producing liposome-containing formulations according to claim 8, characterized in that one or more of the component(s) to be mixed is (are) heated before the formulation is produced.

10. The method according to claims 8 to 9, characterized in that the components to be mixed are pumped from the storage chambers and passed into the micromixer through adjoining thin tubes, each of which ends in a channel of a micromixer, and due to the by pumping building up pressure through the channels of the micromixer with intensive mixing and formation of a liposome-containing formulation.

1. The method according to claims 8 to 10, characterized in that the components to be mixed are pumped from pressurized storage chambers and passed through adjoining thin tubes, each of which ends in a channel of a micromixer, into the micromixer and due to the Pumps of building up pressure are pushed through the channels of the micromixer with intensive mixing and formation of a liposome-containing formulation.

12. Lotion or solution prepared by a method according to claims 1 to 11.

13. Emulsion produced by a process according to claims 1 to 11.

14. Gel, produced by a process according to claims 1 to 11.

15. Cream, produced by a process according to claims 1 to 11.