WO1992019143A3 - Method for the delivery of compositions to the ocular tissues - Google Patents

Method for the delivery of compositions to the ocular tissues Download PDF

Info

Publication number
WO1992019143A3
WO1992019143A3 PCT/US1992/003459 US9203459W WO9219143A3 WO 1992019143 A3 WO1992019143 A3 WO 1992019143A3 US 9203459 W US9203459 W US 9203459W WO 9219143 A3 WO9219143 A3 WO 9219143A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
ocular tissues
composition
tissues
administered
Prior art date
Application number
PCT/US1992/003459
Other languages
French (fr)
Other versions
WO1992019143A2 (en
Inventor
Harvey A Lincoff
Original Assignee
Cornell Res Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cornell Res Foundation Inc filed Critical Cornell Res Foundation Inc
Publication of WO1992019143A2 publication Critical patent/WO1992019143A2/en
Publication of WO1992019143A3 publication Critical patent/WO1992019143A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters

Abstract

Therapeutic compositions are administered to the ocular tissues by positioning a balloon catheter having an illuminating fiberoptic stylette therein in the retrobulbar or parabulbar space of a patient. After the catheter is properly positioned, the composition is sequentially injected at predetermined intervals over a period of time. A variety of compositions can be administered including corticosteroids, antibiotics, macular degeneration alleviating compositions and inflammation alleviating compositions. Such administration of the therapeutic composition sustains appropriate levels of the composition in the ocular tissues without inducing toxic effects in unaffected tissues.
PCT/US1992/003459 1991-04-26 1992-04-27 Method for the delivery of compositions to the ocular tissues WO1992019143A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US691,836 1991-04-26
US07/691,836 US5207660A (en) 1991-04-26 1991-04-26 Method for the delivery of compositions to the ocular tissues

Publications (2)

Publication Number Publication Date
WO1992019143A2 WO1992019143A2 (en) 1992-11-12
WO1992019143A3 true WO1992019143A3 (en) 1992-12-10

Family

ID=24778177

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1992/003459 WO1992019143A2 (en) 1991-04-26 1992-04-27 Method for the delivery of compositions to the ocular tissues

Country Status (2)

Country Link
US (1) US5207660A (en)
WO (1) WO1992019143A2 (en)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5407441A (en) * 1992-06-04 1995-04-18 Greenbaum; Scott Ophthalmologic cannula
US5624422A (en) * 1994-09-22 1997-04-29 The Procter & Gamble Company Absorbent article having an extendible split core
CN1124164C (en) * 1995-05-14 2003-10-15 奥普通诺尔有限公司 Intraocular implant, delivery device, and method of implantation
US5968058A (en) * 1996-03-27 1999-10-19 Optonol Ltd. Device for and method of implanting an intraocular implant
IL113723A (en) * 1995-05-14 2002-11-10 Optonol Ltd Intraocular implant
US8313454B2 (en) * 1997-11-20 2012-11-20 Optonol Ltd. Fluid drainage device, delivery device, and associated methods of use and manufacture
US6203513B1 (en) * 1997-11-20 2001-03-20 Optonol Ltd. Flow regulating implant, method of manufacture, and delivery device
US6015803A (en) * 1998-05-04 2000-01-18 Wirostko; Emil Antibiotic treatment of age-related macular degeneration
US6309374B1 (en) 1998-08-03 2001-10-30 Insite Vision Incorporated Injection apparatus and method of using same
US6378526B1 (en) 1998-08-03 2002-04-30 Insite Vision, Incorporated Methods of ophthalmic administration
US6558342B1 (en) 1999-06-02 2003-05-06 Optonol Ltd. Flow control device, introducer and method of implanting
CA2498489C (en) * 2002-09-29 2010-02-23 Surmodics, Inc. Method for subretinal administration of therapeutics including steroids;method for localizing pharmacodynamic action at the choroid and the retina; and related methods for treatment and/or prevention of retinal diseases
US7862531B2 (en) * 2004-06-25 2011-01-04 Optonol Ltd. Flow regulating implants
US20060110428A1 (en) 2004-07-02 2006-05-25 Eugene Dejuan Methods and devices for the treatment of ocular conditions
CN101180086A (en) * 2005-04-08 2008-05-14 苏尔莫迪克斯公司 Sustained release implants for subretinal delivery
US20080167600A1 (en) * 2005-09-26 2008-07-10 Peyman Gholam A Device for delivery of an agent to the eye and other sites
MX2008014136A (en) * 2006-05-04 2009-03-31 Fovea Pharmaceuticals Sa Combination comprising a vegf inhibitor and a serine protease for treating neovascular diseases.
US7981096B2 (en) * 2006-05-12 2011-07-19 David Castillejos Optic nerve head implant and medication delivery system
EP2043572B1 (en) 2006-06-30 2014-12-31 Aquesys Inc. Apparatus for relieving pressure in an organ
US20120123316A1 (en) * 2010-11-15 2012-05-17 Aquesys, Inc. Intraocular shunts for placement in the intra-tenon's space
US8663303B2 (en) 2010-11-15 2014-03-04 Aquesys, Inc. Methods for deploying an intraocular shunt from a deployment device and into an eye
US8308701B2 (en) 2010-11-15 2012-11-13 Aquesys, Inc. Methods for deploying intraocular shunts
US8852256B2 (en) 2010-11-15 2014-10-07 Aquesys, Inc. Methods for intraocular shunt placement
US8721702B2 (en) 2010-11-15 2014-05-13 Aquesys, Inc. Intraocular shunt deployment devices
US9095411B2 (en) 2010-11-15 2015-08-04 Aquesys, Inc. Devices for deploying intraocular shunts
US10085884B2 (en) 2006-06-30 2018-10-02 Aquesys, Inc. Intraocular devices
US8109896B2 (en) 2008-02-11 2012-02-07 Optonol Ltd. Devices and methods for opening fluid passageways
US20100152646A1 (en) * 2008-02-29 2010-06-17 Reshma Girijavallabhan Intravitreal injection device and method
US8343106B2 (en) 2009-12-23 2013-01-01 Alcon Research, Ltd. Ophthalmic valved trocar vent
BR112012017771B1 (en) 2009-12-23 2020-07-14 Alcon Research, Llc VALVE TROCART CANNULA
US20160256317A1 (en) 2010-11-15 2016-09-08 Aquesys, Inc. Methods for implanting intraocular shunts
US9610195B2 (en) 2013-02-27 2017-04-04 Aquesys, Inc. Intraocular shunt implantation methods and devices
US8852136B2 (en) 2011-12-08 2014-10-07 Aquesys, Inc. Methods for placing a shunt into the intra-scleral space
US10080682B2 (en) 2011-12-08 2018-09-25 Aquesys, Inc. Intrascleral shunt placement
US9808373B2 (en) 2013-06-28 2017-11-07 Aquesys, Inc. Intraocular shunt implantation
US9585790B2 (en) 2013-11-14 2017-03-07 Aquesys, Inc. Intraocular shunt inserter
BR112017025859A2 (en) 2015-06-03 2018-08-14 Aquesys, Inc. external ab intraocular shunt placement
WO2017210627A1 (en) 2016-06-02 2017-12-07 Aquesys, Inc. Intraocular drug delivery
US11246753B2 (en) 2017-11-08 2022-02-15 Aquesys, Inc. Manually adjustable intraocular flow regulation
US11135089B2 (en) 2018-03-09 2021-10-05 Aquesys, Inc. Intraocular shunt inserter
US10952898B2 (en) 2018-03-09 2021-03-23 Aquesys, Inc. Intraocular shunt inserter
CN209847559U (en) * 2018-04-03 2019-12-27 林丁 Remaining needle tube system for eye drug administration

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3954110A (en) * 1974-01-24 1976-05-04 Hutchison Ernest L Retention catheter with bilobate balloon
US4689041A (en) * 1984-01-20 1987-08-25 Eliot Corday Retrograde delivery of pharmacologic and diagnostic agents via venous circulation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3788327A (en) * 1971-03-30 1974-01-29 H Donowitz Surgical implant device
US4299227A (en) * 1979-10-19 1981-11-10 Lincoff Harvey A Ophthalmological appliance
US4454151A (en) * 1982-03-22 1984-06-12 Syntex (U.S.A.) Inc. Use of pyrrolo pyrroles in treatment of ophthalmic diseases
WO1984001513A1 (en) * 1982-10-08 1984-04-26 David Hardcastle Balloon catheter and process for the manufacture thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3954110A (en) * 1974-01-24 1976-05-04 Hutchison Ernest L Retention catheter with bilobate balloon
US4689041A (en) * 1984-01-20 1987-08-25 Eliot Corday Retrograde delivery of pharmacologic and diagnostic agents via venous circulation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
AMERICAN JOURNAL OF OPTHAMOLOGY, Vol. 103, March 1979, FREEMAN et al., "Echographic Localization of Corticosteroids after Periocular Injection", page 281-288. *

Also Published As

Publication number Publication date
US5207660A (en) 1993-05-04
WO1992019143A2 (en) 1992-11-12

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