WO1992012737A1 - Improved method and apparatus for the sterilization of contact lenses utilizing mechanical agitation - Google Patents

Improved method and apparatus for the sterilization of contact lenses utilizing mechanical agitation Download PDF

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Publication number
WO1992012737A1
WO1992012737A1 PCT/US1992/000271 US9200271W WO9212737A1 WO 1992012737 A1 WO1992012737 A1 WO 1992012737A1 US 9200271 W US9200271 W US 9200271W WO 9212737 A1 WO9212737 A1 WO 9212737A1
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WO
WIPO (PCT)
Prior art keywords
hydrogen peroxide
decomposition
contact lenses
sterilization
agitation
Prior art date
Application number
PCT/US1992/000271
Other languages
French (fr)
Inventor
Steven C. Perlaky
Original Assignee
Ciba Vision Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Vision Corporation filed Critical Ciba Vision Corporation
Priority to AU12035/92A priority Critical patent/AU655233B2/en
Priority to KR1019930702109A priority patent/KR930703026A/en
Priority to JP4504536A priority patent/JPH07500427A/en
Publication of WO1992012737A1 publication Critical patent/WO1992012737A1/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L12/00Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
    • A61L12/08Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
    • A61L12/12Non-macromolecular oxygen-containing compounds, e.g. hydrogen peroxide or ozone
    • A61L12/124Hydrogen peroxide; Peroxy compounds
    • A61L12/128Hydrogen peroxide; Peroxy compounds neutralised with catalysts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L12/00Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
    • A61L12/08Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
    • A61L12/086Container, accessories or devices therefor

Definitions

  • This invention relates to sterilization of contact lenses using hydrogen peroxide as the disinfectant, and more particularly relates to improved catalytic control of the decomposition of hydrogen peroxide in the lens disinfection process.
  • This decomposition is critical, since significant hydrogen peroxide residues upon contact lenses can cause harm and irritation to the eyes of contact lens wearers. It has generally been recommended not only to allow sufficient time for nearly complete decomposition of the hydrogen peroxide, but additionally to employ a rinsing solution to flush any potential hydrogen peroxide residues from the lenses before insertion into the eyes.
  • One object of the present invention is to improve the catalytic control over the hydrogen peroxide lens disinfection process, while additionally ensuring that upon completion of the lens disinfection process, the terminal hydrogen peroxide concentration is sufficiently reduced for safe contact by residues adhering to the disinfected lenses with the eyes of the wearer.
  • contact lenses are disinfected in a method including treating the contact lenses with an aqueous system of hydrogen peroxide in the presence of a hydrogen peroxide decomposition catalyst, and mechanically agitating the system in order to accelerate decomposition of the hydrogen peroxide.
  • the initial concentration of hydrogen peroxide is desirably maintained above 1% for lens disinfection during the initial period of lens contact in the system, for example a period of one-half to one full hour, and since the catalytic decomposition of the hydrogen peroxide by many catalytic elements during this initial period is not limited by transport of the hydrogen peroxide molecules to the catalytic surface, the activation of mechanical agitation of the disinfection system can be optionally delayed without lengthening the desired decomposition progress.
  • the initial concentration of hydrogen peroxide in the system is approximately 3-4% and even delayed mechanical agitation promotes decomposition of the hydrogen peroxide to a concentration of less than 50 parts per million within less than 6 hours following initial contact of the catalyst with the system.
  • even the delayed mechanical agitation can achieve reduction of the hydrogen peroxide concentration to less than 10 ppm in a shorter period of total elapsed time of catalyst contact with the system, so that the required duration of the lens disinfection operation can be reduced.
  • the catalytic decomposition can be performed in a conventional lens sterilization vessel which is secured to a drive mechanism for repeated motion of the reaction vessel in a time delayed manner, in order to maintain continuous agitation of the sterilization system therein.
  • FIG. 1 is an elevation view illustrating of a conventional contact lens sterilization case containing a hydrogen peroxide system, which is inserted into a receptacle which has an electrically powered motion generator of any conventional design which agitates the vessel and the contained sterilization system;
  • FIG. 2 is a sectional view of the receptacle in FIG. 1 showing the inserted lens case in phantom illustration and an oscillatory motion generated to agitate the lens case in one embodiment of the invention.
  • Appliance 10 includes a generally cylindrical reaction vessel 12 which has an open top on which the cap member 14 is removably threaded.
  • the reaction vessel 12 is designed to contain a contact lens sterilizing solution of aqueous hydrogen peroxide 16.
  • the conventional solution 16 is approximately 3%-4% hydrogen peroxide buffered for sterilization of typical soft contact lenses. Initial concentration of the hydrogen peroxide solution can be varied to suit the sterilization application and decomposition catalyst.
  • a lens support structure generally designated by reference numeral 18 which projects downwardly into the container 12 to immerse a pair of contact lenses 20 in the sterilization solution when the cap 14 is mounted thereon as shown.
  • the support structure includes a pair of pivotal lens holder cover members 22 which enclose a respective lens 20 within the support structure while enabling the passage of the sterilization solution therethrough in conventional manner.
  • a hydrogen peroxide decomposition catalyst element 24 is removably inserted and retained at the bottom of the container 12 in conventional manner. Examples of typical lens cases of the general type referred to above can be found in United States Patent Nos. 4,956,156; 4,013,410; and 4,750,610, the disclosure of which are incorporated herein by reference.
  • suitable hydrogen peroxide decomposition catalysts include metals from Periods 4, 5 and 6 of the Periodic Chart of Elements and the Lanthanide elements which are disposed on a carrier or substrate to extend the active surface of the catalytic metal.
  • the metal hydrogen peroxide decomposition catalysts belonging to the aforementioned Periods 4, 5 and 6 are, for example, Pt, Pd, Ir, Rh, Re, Au, Ag, Cu, Cr, Os, Co, Fe, Mo, W, Mn, Ce and Th.
  • platinum is the preferred hydrogen peroxide decomposition catalytic metal.
  • the platinum is disposed on an inexpensive support material which can be fabricated to provide a resulting catalytic element with extensive active surface area.
  • Particularly suitable materials for the substrate support include polymeric materials on which the catalytic platinum can be securely disposed.
  • the platinum metal can be deposited on the polymeric substrate using metal deposition techniques such as chemical deposition, vapor deposition, vacuum metalization, electroplating, or sputtering as more fully described in the aforementioned U.S. Patent 3,912,451.
  • the contact lenses 20 are placed within the lens support structure 22. Hydrogen peroxide sterilization solution is then poured into the vessel 12 which contains the catalytic element.
  • the catalytic element may be carried on the lens support structure so that the lenses and the catalytic element are immersed in the hydrogen peroxide solution at the same time as more fully described in co-pending U.S. Patent Application Serial No. 07/361,471 filed June 9, 1989, entitled Apparatus for Sterilizing Contact Lenses which is incorporated by reference herein.
  • the lens case or vessel 12 is then subjected to repeated mechanical agitation preferably in continuous oscillating motion indicated by arrow A, for example, by securing the vessel to an electrically driven oscillator mechanism 26, or similar motion generator.
  • the mechanism 26 may be of various designs, its purpose being to produce agitation of the lens case 10.
  • the unit 26 as illustrated includes a housing 28 in which there is mounted a support 30 for the lens case 10.
  • the support 30 is resiliently mounted by a mounting means or spring 32.
  • a timer module 33 delays activation of an electrically driven oscillator 34 which imparts oscillating motion A to the support 30 which in turn produces the desired oscillation of the lens case 10.
  • the mechanical agitation of the vessel and contained aqueous system then promotes accelerated diffusion and transport of the progressively diluted hydrogen peroxide molecules into contact with the decomposition catalyst to reduce the concentration of any residual hydrogen peroxide remaining after sterilization treatment of the contact lenses.
  • EXAMPLES The following table indicates the comparative performance of hydrogen peroxide decomposition within contact lens sterilization systems conducted both with and without mechanical agitation.
  • a pair of soft contact lenses was subjected to hydrogen peroxide decomposition sterilization using a typical hydrogen peroxide buffered solution of approximately 3.75% in a conventional appliance as illustrated in FIG. 1 containing a typical catalytic element provided by sputtered platinum deposited on phenylene oxide polymeric support commercially supplied by General Electric Company under the trademark NorylTM, in conventional manner.
  • the mechanically agitated or vibrated system designated A was evaluated by mounting the contact lens case on a small electrically driven vibration generator.
  • the system designated B was not mechanically agitated.
  • the hydrogen peroxide concentration was reduced from initial concentration of approximately 3.75% to approximately 1% in generally the same time of approximately 23-25 minutes, however, hydrogen peroxide concentration of the vibrated system A was further reduced after six hours to less than 7 parts per million, while the hydrogen peroxide concentration of the unvibrated system B after six hours was reduced only to a level of approximately 251 parts per million, representing a potential risk of eye irritation to a contact lens wearer and exceeding the guideline maximum of 50 parts per million hydrogen peroxide for safe eye contact.

Abstract

Contact lenses are disinfected in a method including treating the contact lenses with an aqueous system of hydrogen peroxide in the presence of a hydrogen peroxide decomposition catalyst, and mechanically agitating the system in order to accelerate decomposition of the hydrogen peroxide. In a preferred embodiment of the method, the initial concentration of hydrogen peroxide in the system is approximately 3-4 % and the mechanical agitation promotes decomposition of the hydrogen peroxide to a concentration of 50 parts per million or less within 6 hours following initial contact of the catalyst with the system. The catalytic decomposition can be performed in a conventional lens sterilization vessel (12) which is secured to a drive mechanism (26) for repeated motion of the reaction vessel (12) in order to maintain continuous agitation of the sterilization system (10) therein.

Description

IMPROVED METHOD AND APPARATUS FOR THE STERILIZATION OF CONTACT LENSES UTILIZING MECHANICAL AGITATION
BACKGROUND OF THE INVENTION
This invention relates to sterilization of contact lenses using hydrogen peroxide as the disinfectant, and more particularly relates to improved catalytic control of the decomposition of hydrogen peroxide in the lens disinfection process.
The well-known, commercialized soft contact lens disinfection process employing hydrogen peroxide solution as a bactericide is described for example in U.S. patents 4,750,610; 4,013,410 and 3,912,451. Recent improvements in contact lens cases for conducting such disinfection process are described in co-pending U.S. Patent application Serial No. 364,471 filed June 9, 1989, the disclosure of which is incorporated by reference herein. In such process, the contact lenses are immersed overnight in a weak bactericidal solution of hydrogen peroxide, approximately 3%, which solution is also subjected to a platinum catalyst to promote gradual decomposition of the hydrogen peroxide, viz., into water and liberated oxygen. This decomposition is critical, since significant hydrogen peroxide residues upon contact lenses can cause harm and irritation to the eyes of contact lens wearers. It has generally been recommended not only to allow sufficient time for nearly complete decomposition of the hydrogen peroxide, but additionally to employ a rinsing solution to flush any potential hydrogen peroxide residues from the lenses before insertion into the eyes.
In addition to the decomposition of the hydrogen peroxide, it is also important that the lenses be exposed to the relevant maximum strength of the disinfectant solution for sufficient time to destroy the harmful bacteria. Thus, the decomposition must not be too rapid, otherwise the lenses will not be thoroughly disinfected. The decomposition process, however, must be complete after a period of time to protect the eyes. One object of the present invention is to improve the catalytic control over the hydrogen peroxide lens disinfection process, while additionally ensuring that upon completion of the lens disinfection process, the terminal hydrogen peroxide concentration is sufficiently reduced for safe contact by residues adhering to the disinfected lenses with the eyes of the wearer.
SUMMARY OF THE INVENTION
In accordance with the present invention, contact lenses are disinfected in a method including treating the contact lenses with an aqueous system of hydrogen peroxide in the presence of a hydrogen peroxide decomposition catalyst, and mechanically agitating the system in order to accelerate decomposition of the hydrogen peroxide. Since the initial concentration of hydrogen peroxide is desirably maintained above 1% for lens disinfection during the initial period of lens contact in the system, for example a period of one-half to one full hour, and since the catalytic decomposition of the hydrogen peroxide by many catalytic elements during this initial period is not limited by transport of the hydrogen peroxide molecules to the catalytic surface, the activation of mechanical agitation of the disinfection system can be optionally delayed without lengthening the desired decomposition progress. In preferred embodiments of the method, the initial concentration of hydrogen peroxide in the system is approximately 3-4% and even delayed mechanical agitation promotes decomposition of the hydrogen peroxide to a concentration of less than 50 parts per million within less than 6 hours following initial contact of the catalyst with the system. Generally, even the delayed mechanical agitation can achieve reduction of the hydrogen peroxide concentration to less than 10 ppm in a shorter period of total elapsed time of catalyst contact with the system, so that the required duration of the lens disinfection operation can be reduced.
The catalytic decomposition can be performed in a conventional lens sterilization vessel which is secured to a drive mechanism for repeated motion of the reaction vessel in a time delayed manner, in order to maintain continuous agitation of the sterilization system therein.
BRIEF DESCRIPTION OF THE DRAWINGS
FIG. 1 is an elevation view illustrating of a conventional contact lens sterilization case containing a hydrogen peroxide system, which is inserted into a receptacle which has an electrically powered motion generator of any conventional design which agitates the vessel and the contained sterilization system;
SUB FIG. 2 is a sectional view of the receptacle in FIG. 1 showing the inserted lens case in phantom illustration and an oscillatory motion generated to agitate the lens case in one embodiment of the invention.
DESCRIPTION OF THE PREFERRED EMBODIMENT
Referring to FIG. 1, a typical sterilizing appliance or lens case which can be employed in accordance with the present invention is designated generally by reference numeral 10. Appliance 10 includes a generally cylindrical reaction vessel 12 which has an open top on which the cap member 14 is removably threaded. The reaction vessel 12 is designed to contain a contact lens sterilizing solution of aqueous hydrogen peroxide 16. The conventional solution 16 is approximately 3%-4% hydrogen peroxide buffered for sterilization of typical soft contact lenses. Initial concentration of the hydrogen peroxide solution can be varied to suit the sterilization application and decomposition catalyst. Depending from and welded to the cap 14 is a lens support structure generally designated by reference numeral 18 which projects downwardly into the container 12 to immerse a pair of contact lenses 20 in the sterilization solution when the cap 14 is mounted thereon as shown. The support structure includes a pair of pivotal lens holder cover members 22 which enclose a respective lens 20 within the support structure while enabling the passage of the sterilization solution therethrough in conventional manner. A hydrogen peroxide decomposition catalyst element 24 is removably inserted and retained at the bottom of the container 12 in conventional manner. Examples of typical lens cases of the general type referred to above can be found in United States Patent Nos. 4,956,156; 4,013,410; and 4,750,610, the disclosure of which are incorporated herein by reference.
In the present invention, suitable hydrogen peroxide decomposition catalysts include metals from Periods 4, 5 and 6 of the Periodic Chart of Elements and the Lanthanide elements which are disposed on a carrier or substrate to extend the active surface of the catalytic metal. Among the metal hydrogen peroxide decomposition catalysts belonging to the aforementioned Periods 4, 5 and 6 are, for example, Pt, Pd, Ir, Rh, Re, Au, Ag, Cu, Cr, Os, Co, Fe, Mo, W, Mn, Ce and Th. Particularly for commercial reasons, platinum is the preferred hydrogen peroxide decomposition catalytic metal. Preferably, the platinum is disposed on an inexpensive support material which can be fabricated to provide a resulting catalytic element with extensive active surface area. Particularly suitable materials for the substrate support include polymeric materials on which the catalytic platinum can be securely disposed. The platinum metal can be deposited on the polymeric substrate using metal deposition techniques such as chemical deposition, vapor deposition, vacuum metalization, electroplating, or sputtering as more fully described in the aforementioned U.S. Patent 3,912,451.
In use, the contact lenses 20 are placed within the lens support structure 22. Hydrogen peroxide sterilization solution is then poured into the vessel 12 which contains the catalytic element. Alternatively, the catalytic element may be carried on the lens support structure so that the lenses and the catalytic element are immersed in the hydrogen peroxide solution at the same time as more fully described in co-pending U.S. Patent Application Serial No. 07/361,471 filed June 9, 1989, entitled Apparatus for Sterilizing Contact Lenses which is incorporated by reference herein. Optionally, after appropriate delay time of, for example, 1/2 to 1 hour, the lens case or vessel 12 is then subjected to repeated mechanical agitation preferably in continuous oscillating motion indicated by arrow A, for example, by securing the vessel to an electrically driven oscillator mechanism 26, or similar motion generator. The mechanism 26 may be of various designs, its purpose being to produce agitation of the lens case 10. For example, the unit 26 as illustrated includes a housing 28 in which there is mounted a support 30 for the lens case 10. The support 30 is resiliently mounted by a mounting means or spring 32. A timer module 33 delays activation of an electrically driven oscillator 34 which imparts oscillating motion A to the support 30 which in turn produces the desired oscillation of the lens case 10. The mechanical agitation of the vessel and contained aqueous system then promotes accelerated diffusion and transport of the progressively diluted hydrogen peroxide molecules into contact with the decomposition catalyst to reduce the concentration of any residual hydrogen peroxide remaining after sterilization treatment of the contact lenses.
The following examples are illustrative of embodiments in accordance with the present invention but do not indicate limitation upon the scope of the claims.
EXAMPLES The following table indicates the comparative performance of hydrogen peroxide decomposition within contact lens sterilization systems conducted both with and without mechanical agitation. In each of the indicated systems a pair of soft contact lenses was subjected to hydrogen peroxide decomposition sterilization using a typical hydrogen peroxide buffered solution of approximately 3.75% in a conventional appliance as illustrated in FIG. 1 containing a typical catalytic element provided by sputtered platinum deposited on phenylene oxide polymeric support commercially supplied by General Electric Company under the trademark Noryl™, in conventional manner. The mechanically agitated or vibrated system designated A was evaluated by mounting the contact lens case on a small electrically driven vibration generator. The system designated B was not mechanically agitated.
H O Concentration Vibrated System at 6 hr. duration
A 6.9 ppm
Unvibrated System
B 250.8 ppm
In both of systems A and B, the hydrogen peroxide concentration was reduced from initial concentration of approximately 3.75% to approximately 1% in generally the same time of approximately 23-25 minutes, however, hydrogen peroxide concentration of the vibrated system A was further reduced after six hours to less than 7 parts per million, while the hydrogen peroxide concentration of the unvibrated system B after six hours was reduced only to a level of approximately 251 parts per million, representing a potential risk of eye irritation to a contact lens wearer and exceeding the guideline maximum of 50 parts per million hydrogen peroxide for safe eye contact.
While particular embodiments of the present invention have been described herein, it will be obvious to those skilled in the art that changes and modifications in various aspects may be made without departing from the broad scope of the invention.
Consequently, the scope of the invention is not limited by any particular embodiment but is defined by the appended claims and the equivalents thereof.

Claims

The Invention is Claimed as Follows:
1. A method for disinfecting contact lenses comprising: a) treating contact lenses with an aqueous system including hydrogen peroxide in the presence of a hydrogen peroxide decomposition catalyst; and b) simultaneously mechanically agitating said system in order to accelerate decomposition of said hydrogen peroxide.
2. A method according to claim 1, wherein the initial concentration of said hydrogen peroxide in said system is approximately 3-4% and said mechanical agitation promotes decomposition of said hydrogen peroxide to a concentration less than 50 ppm within less than 6 hours following an initial contact of said catalyst with said system.
3. A method according to claim 1, further comprising delaying activation of said simultaneous mechanical agitation following initiation of said treating step (a) .
4. Apparatus for disinfecting contact lenses, comprising: a) a reaction vessel for containing contact lenses and an aqueous system including hydrogen peroxide in the presence of a hydrogen decomposition catalyst; and b) agitation means for agitating said system in order to accelerate decomposition of said hydrogen peroxide.
5. Apparatus according to claim 4, wherein said agitation means comprises drive means for driving repeated motion of said reaction vessel in order to maintain continuous agitation of said system therewithin.
6. Apparatus according to claim 4, further comprising timing means for delaying activation of said
SUBSTITUTE SHEET agitation means following initiation of said disinfecting.
PCT/US1992/000271 1991-01-15 1992-01-15 Improved method and apparatus for the sterilization of contact lenses utilizing mechanical agitation WO1992012737A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU12035/92A AU655233B2 (en) 1991-01-15 1992-01-15 Improved method and apparatus for the sterilization of contact lenses utilizing mechanical agitation
KR1019930702109A KR930703026A (en) 1991-01-15 1992-01-15 Improved method and apparatus for cleaning contact lenses using mechanical fluctuations
JP4504536A JPH07500427A (en) 1991-01-15 1992-01-15 Improvement of contact lens sterilization method and device using mechanical rocking

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64153291A 1991-01-15 1991-01-15
US641,532 1991-01-15

Publications (1)

Publication Number Publication Date
WO1992012737A1 true WO1992012737A1 (en) 1992-08-06

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PCT/US1992/000271 WO1992012737A1 (en) 1991-01-15 1992-01-15 Improved method and apparatus for the sterilization of contact lenses utilizing mechanical agitation

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EP (1) EP0567561A4 (en)
JP (1) JPH07500427A (en)
KR (1) KR930703026A (en)
AU (1) AU655233B2 (en)
CA (1) CA2100575A1 (en)
WO (1) WO1992012737A1 (en)

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Publication number Priority date Publication date Assignee Title
US3871395A (en) * 1973-02-26 1975-03-18 Fibra Sonics Ultrasonic/chemical cleaner for contact lenses
US3973760A (en) * 1974-07-19 1976-08-10 Robert E. McClure Ultrasonic cleaning and sterilizing apparatus
US4396583A (en) * 1981-08-14 1983-08-02 American Optical Corporation Device for single solution contact lens sterilization
US4597399A (en) * 1984-12-17 1986-07-01 Ryder International Corporation Vibrator actuated lens cleaning system
US4653519A (en) * 1985-07-09 1987-03-31 Ryder International Corporation Rinsing apparatus for contact lens cleaning system
US4735223A (en) * 1985-06-12 1988-04-05 Angel Ituarte Process and apparatus for cleaning and sterilizing of contact lenses
US4779633A (en) * 1986-11-15 1988-10-25 Henkel Kommanditgesellschaft Auf Aktien Apparatus for the care of contact lenses
US4784167A (en) * 1986-11-15 1988-11-15 Henkel Kommanditgesellschaft Auf Aktien Apparatus for the care of contact lenses
US4852591A (en) * 1986-07-03 1989-08-01 Henkel Kommanditgesellschaft Auf Aktien Apparatus for the care of contact lenses
US4852592A (en) * 1987-08-13 1989-08-01 Digangi And Ross Apparatus for the cleaning of contact lenses
US4889693A (en) * 1988-01-22 1989-12-26 Ciba-Geigy Corporation Apparatus for venting of gases from contact lens cases
US4907613A (en) * 1988-09-12 1990-03-13 Litzaw Edgar M Contact lens cleaning device

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5078798A (en) * 1989-12-28 1992-01-07 Ciba-Geigy Corporation Buoyancy mediated control of catalytic reaction

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3871395A (en) * 1973-02-26 1975-03-18 Fibra Sonics Ultrasonic/chemical cleaner for contact lenses
US3973760A (en) * 1974-07-19 1976-08-10 Robert E. McClure Ultrasonic cleaning and sterilizing apparatus
US4396583A (en) * 1981-08-14 1983-08-02 American Optical Corporation Device for single solution contact lens sterilization
US4597399A (en) * 1984-12-17 1986-07-01 Ryder International Corporation Vibrator actuated lens cleaning system
US4735223A (en) * 1985-06-12 1988-04-05 Angel Ituarte Process and apparatus for cleaning and sterilizing of contact lenses
US4653519A (en) * 1985-07-09 1987-03-31 Ryder International Corporation Rinsing apparatus for contact lens cleaning system
US4852591A (en) * 1986-07-03 1989-08-01 Henkel Kommanditgesellschaft Auf Aktien Apparatus for the care of contact lenses
US4779633A (en) * 1986-11-15 1988-10-25 Henkel Kommanditgesellschaft Auf Aktien Apparatus for the care of contact lenses
US4784167A (en) * 1986-11-15 1988-11-15 Henkel Kommanditgesellschaft Auf Aktien Apparatus for the care of contact lenses
US4852592A (en) * 1987-08-13 1989-08-01 Digangi And Ross Apparatus for the cleaning of contact lenses
US4889693A (en) * 1988-01-22 1989-12-26 Ciba-Geigy Corporation Apparatus for venting of gases from contact lens cases
US4907613A (en) * 1988-09-12 1990-03-13 Litzaw Edgar M Contact lens cleaning device

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP0567561A4 *

Also Published As

Publication number Publication date
EP0567561A1 (en) 1993-11-03
CA2100575A1 (en) 1992-08-06
KR930703026A (en) 1993-11-29
AU1203592A (en) 1992-08-27
AU655233B2 (en) 1994-12-08
JPH07500427A (en) 1995-01-12
EP0567561A4 (en) 1993-12-01

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