US3902489A - Couplings - Google Patents
Couplings Download PDFInfo
- Publication number
- US3902489A US3902489A US372848A US37284873A US3902489A US 3902489 A US3902489 A US 3902489A US 372848 A US372848 A US 372848A US 37284873 A US37284873 A US 37284873A US 3902489 A US3902489 A US 3902489A
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- US
- United States
- Prior art keywords
- diaphragms
- coupling
- equipment
- diaphragm
- bellows
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- Expired - Lifetime
Links
- 230000008878 coupling Effects 0.000 title claims abstract description 87
- 238000010168 coupling process Methods 0.000 title claims abstract description 87
- 238000005859 coupling reaction Methods 0.000 title claims abstract description 87
- 239000000463 material Substances 0.000 claims abstract description 39
- 239000002904 solvent Substances 0.000 claims abstract description 22
- 239000012530 fluid Substances 0.000 claims abstract description 19
- 229920000915 polyvinyl chloride Polymers 0.000 claims description 12
- 239000004800 polyvinyl chloride Substances 0.000 claims description 12
- 230000000149 penetrating effect Effects 0.000 claims description 8
- 229920003023 plastic Polymers 0.000 claims description 8
- 239000004033 plastic Substances 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 6
- 230000006835 compression Effects 0.000 claims description 4
- 238000007906 compression Methods 0.000 claims description 4
- 238000007789 sealing Methods 0.000 claims description 4
- 230000004888 barrier function Effects 0.000 claims description 3
- 125000002243 cyclohexanonyl group Chemical group *C1(*)C(=O)C(*)(*)C(*)(*)C(*)(*)C1(*)* 0.000 claims description 2
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexyloxide Natural products O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 claims description 2
- 230000035515 penetration Effects 0.000 claims description 2
- 230000036512 infertility Effects 0.000 abstract description 5
- 239000000356 contaminant Substances 0.000 abstract description 4
- 239000007787 solid Substances 0.000 abstract description 4
- 230000015572 biosynthetic process Effects 0.000 abstract description 2
- 239000008280 blood Substances 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 7
- 244000005700 microbiome Species 0.000 description 7
- 239000000645 desinfectant Substances 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005194 fractionation Methods 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 101100264195 Caenorhabditis elegans app-1 gene Proteins 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000006104 solid solution Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000011877 solvent mixture Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/10—Tube connectors; Tube couplings
- A61M39/14—Tube connectors; Tube couplings for connecting tubes having sealed ends
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/22—Valves or arrangement of valves
- A61M39/221—Frangible or pierceable closures within tubing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/10—Bag-type containers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1475—Inlet or outlet ports
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S604/00—Surgery
- Y10S604/905—Aseptic connectors or couplings, e.g. frangible, piercable
Definitions
- Sleeves surrounding the diaphragms are preferably also unified together by the same solvent.
- couplings have to be made between elements such as bags and tubes to establish a fluid flow path of a particular character, without however exposing the interior of the coupling or the other elements or the fluid to harm, e.g. by infection by harmful microorganisms, or by other entrapped contamination such as chemical contaminants.
- a particular area in which the problem presents great difficulties is that of blood transfusion and in particular in the handling and the fractionation of blood once it has been received from the donor.
- the blood is treated by various methods most of which include centrifuging and freezing in an array of three or even more bags linked to each other by closable tubes.
- a first separation is done in the first bag and one of the fractions is pressed from that bag into a second where a further operation is carried out and then a fraction from the second bag is returned either to the first or to a third bag and so on.
- the coupling is assembled in a disinfectant bath because if microorganisms are trapped between the parts of the coupling and in particular between the diaphragms they may pass into the fluid stream or may even be driven into it by the needle when that pushes through the diaphragms.
- a coupling for medical or research equipment for example blood transfusion processing apparatus, wherein elements coupled together are sealed off by penetratable diaphragms one diaphragm being associated with each part of the coupling, the two diaphragms being unified together face to face by a solvent for the material of the diaphragms, and an internal means within the coupling for penetrating through the diaphragms when unified together.
- the coupling includes male and female sleeves surrounding the diaphragm and forming a push-fit together, and the solvent for the material of the diaphragms is also a solvent for the sleeve parts and is applied between them whereby the coupling parts are unified over substantially the whole of the interacting surfaces of the sleeves and the diaphragms.
- equipment for the handling of fluid which consists of at least two bags connected together by at least one tube, a coupling between the tube and. at least one of the bags including diaphragms unified by a solvent for the material of the diaphragms, the diaphragms respectively forming a barrier to access to the tubes and to the at least one of the bags, and means inside the coupling for penetrating the diaphragms when sealed together to open up a fluid path from the at least one bag to the tube.
- FIG. 1 illustrates schematically a prior art arrangement of bag set
- FIG. 2 illustrates schematically a bag set embodying the present invention
- FIG. 3 shows, a male element and FIG. 4 a female element of the coupling embodying the invention, both in a diametrical section,
- FIG. 5 shows, in a larger scale the elements assem bled and with diaphragms unified together
- FIG. 6 illustrates how a fluid path is opened through the unified diaphragms.
- FIG. I of the drawing we show a prior art bag set consisting of bags a, b and c, which are interlinked respectively by tubes 1 .and 2 each having socket parts 3 on their ends fitting over plugs extending from the bags u, b, and c.
- the sockets 3 may be glued onto the plugs.
- Each of these tubes is open ended at each end as are also the plugs of the bags so that sterility of the whole assembly is achieved only by sterilisation of the component parts and their assembly together into a sealed set all under sterile conditions. It is obvious the set cannot be dis-assembled in any way while maintaining sterility, except destructively (the method usually used being sealing-off tubes 1 or 2 by heating them and then cutting them beyond the seal).
- FIG. 2 we show elements of a bag set embodying the present invention.
- An inlet 6 to the first bag a is shown wherein for example blood from a donor may be first introduced into the bag set.
- This connection may be one according to the invention or may be a conventional one.
- Each of the bags has a plug 7 which may be one element of a coupling according to the invention or may be a known type of plug with a tear-off seal to allow access to the final contents of the bag when they are to be used.
- bags may be sent out from the factory as they are in sterile and sealed condition to the user. They may be all the same size as is shown here or may be of a range of sizes which rationally should include only two sizes and not more. Since the bags are totally sealed they cannot be sterilised by ordinary heat treatment since they contain air and may contain for example anticoagulants, and they are therefore sterilised by irradiation preferably by gamma rays. Also making up part of the bag set are tubes such as 8 which have at each end a male element 9 for the coupling embodying the invention.
- any of the male elements 9 will fit any of the female elements 5 on any of the bags a to c and thus the user may assemble with the bags and with the tubes he is given a set of bags which is uniquely adapted to his own requirements.
- Each of the male elements 9, which will be described in more detail later, contains a diaphragm sealing off the interior of the tube to the outside atmosphere and the tubes are sent out in internally sterile condition having been sterilised by irradiation again preferably by irradiation with gamma rays.
- FIG. 4 also shows how the female socket elements need not necessarily be integral with bags but may form the end fitting of a tube. It is equally possible that the male elements 9 may be integral with the bags.
- the female socket part 5 has a sleeve at 10 across which is formed a diaphragm 11.
- the sleeve is integral with a fitting 12 for receiving the end of a tube 8' as shown in FIG. 4 or the sleeve 10 may be moulded integrally with a bag.
- the male element 9 is sealed off by a diaphragm 13 at the axially outer end of a sleeve 14 of which the outer diameter is such that the sleeves l4 and 10 are a tight push-fit together.
- a bellows construction 15 allows for relative axial movement of the sleeve 14 and another sleeve 16 of similar diameter at the other end of the bellows.
- This sleeve 16 constitutes a fitting in which the end of a tube such as 8 is securely fixed.
- annular collar 17 which is a base for a hollow needle 18 which extends axially from that base within the sleeve 16 to Within the sleeve 14 and presents a sharp point 19 towards the diaphragm 13.
- the needle point 19 is clear of the diaphragm 13.
- the needle 18 has a pair of ports 20 near its pointed end so there may be fluid communication from that pointed end through the hollow needle and the collar 17 into the tube 8.
- all the parts mentioned including the needle are formed of plastics material although the needle may of course be of metal.
- a preferred material for the plastics is a polyvinyl chloride material since this is cheap, readily workable and not difficult to sterilise.
- a solvent particularly suitable for use with polyvinyl chloride is cyclohexanone since this has, incidentally, an appreciable sterilizing effect of its own.
- both diaphragms With an ample coating of a solvent for the material of those diaphragms. Obviously from the commercial point of view it would be desirable to make both diaphragms of the same material so that the widest range of solvents is available but obviously the diaphragms could be of different materials, and then a common solvent or else a solvent mixture would have to be used. The diaphragms are then pressed together face to face and left until the joint has solidifed.
- the material of the diaphragms should be the same as that of the sleeves l0 and 14 and then the same solvent may be also used between the touching surfaces of the sleeves and a unified joint may be formed overall to give mechanical strength to the seal.
- the layer 21 in FIG. 4 between the diaphragms is a solid layer of material common to each diaphragm while layer 22 is made up of material common to the sleeves l0 and 14.
- any micro-organisms on the formerly exposed outer surfaces of the diaphragms are locked into the solid joint formed between the diaphragms by the layer 21 and when the needle 18 is pushed through the diaphragms so as to establish a fluid path through the coupling there is a statistically negligible risk that any viable micro-organisms will be introduced into that flow path.
- the needle may remain penetrating the diaphragms so that the ports 20 remain beyond the diaphragms and fluid issues from them beyond the diaphragms, or may be withdrawn again so that the hole that it has pierced through the diaphragms is used for the passage of fluid.
- the assembly step of the coupling need not be done under sterile conditions, the only precaution necessary being that a complete and adequate coating of solvent material is applied to the faces of the diaphragms.
- the internal penetrating elements may be attached to a bellows on as female socket element rather on a male, as shown here, or may be entirely loose within either element of the coupling (cf German Auslegeschrift No. 1300635).
- Equipment for the handling of fluid which comprises at least two bags connected together by at least one tube, a coupling between the tube and at least one of the bags including diaphragms unified by a solvent for the material of the diaphragms, the diaphragms respectively forming a barrier to access to the tubes and to the at least one of the bags, and means inside the coupling for penetrating the diaphragms when sealed together to open up a fluid path from the at least one bag to the tube.
- the coupling includes male and female sleeves surrounding the respective diaphragms and forming a push-fit together, the coupling parts being unified over substantially the whole of the irreracting surfaces of the sleeves and the diaphragm by a resolidified region of their respective materials.
- the said coupling includes an axially compressible bellows intermediate at least one tube and the diaphragms and the said means inside the coupling includes a needle mounted within the bellows with one end presented towards the diaphragm and one anchored to the end of the bellows remote from the diaphragm, whereby axial compression of the bellows can drive the needle through the diaphragm.
- a modular coupled equipment system comprising a plurality of items of medical or research equipment sealingly attached together in temporarily nonintercommunicating manner, and adapted to be made intercommunicating for use, comprising a plurality of coupled-together sets of individual coupling elements and respective items of equipment, each set comprising a coupling element and an item of equipment attached thereto, each coupling element comprising a housing, and a coupling passage extending through the housing and open at each end, the coupling element being attached to the item of equipment so that one open end of the coupling passage communicates with the item of equipment; a penetrable diaphragm disposed across the coupling passage and sealing off the passage from flow therethrough until penetrated; the housing of each coupling element at the other open end of the passage being shaped to sealingly interconnect with the coupling element of another set to which it is sealingly attached, the coupling passages of interconnected coupling elements being aligned to form an intercommunicating through passage extending to each item of equipment closed off by the diaphragm in the coupling
- interconnected coupling components comprise interconnected male and female sleeves surrounding the respective diaphragms and forming a pushfit together, the coupling components being united over substantially the whole of the abutting surfaces of the sleeves and the diaphragms by interdiffusion of diaphragm material.
- a modular coupled equipment system according to claim 8 wherein the plastic material is polyvinyl chloride.
- a modular coupled equipment system according to claim 6 wherein the said internal means includes an axially compressible bellows, a needle mounted within the bellows with one end presented towards the diaphragm and one anchored to the end of the bellows remote from the diaphragm, whereby axial compression of the bellows can drive the needle through the diaphragm.
Abstract
A coupling, particularly for blood-processing sets, is shown which permits the assembly of a ''''kit of parts'''' of such a set by a user not under special conditions of sterility. This is achieved by terminating the items of the kit e.g. bags and tubes in frangible diaphragms and joining the items by means of a solvent for the material of the diaphragms so that they are unified together. They may then be ruptured to open up a fluid path through the items. Sleeves surrounding the diaphragms are preferably also unified together by the same solvent. By the formation of such a solid layer of the material of the diaphragms between them and uniting them, ingress of contaminants from the previously exposed faces of the diaphragms when the diaphragms are ruptured is hindered or prevented.
Description
ited States Carter T atet 11 1 14 1 Sept. 2, 1975 1 COUPLINGS [75] Inventor: Douglas Vaughan Carter, Great Malvern, England 22 Filed: June 22,1973 21 App1.No.:372 ,848
[30] Foreign Application Priority Data June 23, 1972 United Kingdom 29524/72 52 11.8. c1 128/214 R; l28/2l4.2; 222/83; 285/3 51 111001 A6lm 05/00 [58] Field of Search 128/214 R, 214 c, 214 D, 128/214.2, 215, 272; 285/3; 137/68;
[56] References Cited UNITED STATES PATENTS 2,847,995 8/1958 Adams 128/214 R 2,933,333 4/1960 Bredtschneider et al. 285/3 2,954,769 10/1960 Callahan et al 128/214.2 X 3,127,892 4/1964 Bellamy et a1. 128/214.2 3,306,563 2/1967 Soto 128/214 R X 3,336,924 8/1967 Sarnoff et 128/218 M X 3,416,528 12/1968 Kahn 128/214.2
FORElGN PATENTS OR APPLICATIONS 1,300,635 8/1969 Germany 128/214 R 1,528,025 4/1968 France 128/214 D Primary Examiner-Dalton 1L. Truluck [5 7 ABSTRACT A coupling, particularly for blood-processing sets, is shown which permits the assembly of a kit of parts of such a set by a user not under special conditions of sterility. This is achieved by terminating the items of the kit e.g. bags and tubes in frangible diaphragms and joining the items by means of a solvent for the material of the diaphragms so that they are unified together. They may then be ruptured to open up a fluid path through the items. Sleeves surrounding the diaphragms are preferably also unified together by the same solvent. By the formation of such a solid layer of the material of the diaphragms between them and uniting them, ingress of contaminants from the previously exposed faces of the diaphragms when the diaphragms are ruptured is hindered or prevented.
16 Claims, 6 Drawing Figures PATENTED 2|975 3,902,489
sum 1 0f 2 COUPLINGS FIELD OF THE INVENTION This invention relates to couplings used in the medical and research contexts.
BACKGROUND OF THE INVENTION In these uses, couplings have to be made between elements such as bags and tubes to establish a fluid flow path of a particular character, without however exposing the interior of the coupling or the other elements or the fluid to harm, e.g. by infection by harmful microorganisms, or by other entrapped contamination such as chemical contaminants.
A particular area in which the problem presents great difficulties is that of blood transfusion and in particular in the handling and the fractionation of blood once it has been received from the donor.
For this fractionation, the blood is treated by various methods most of which include centrifuging and freezing in an array of three or even more bags linked to each other by closable tubes. A first separation is done in the first bag and one of the fractions is pressed from that bag into a second where a further operation is carried out and then a fraction from the second bag is returned either to the first or to a third bag and so on.
The interior of all these bags and of the tubes linking them have to be absolutely sterile. These bag sets have always been pre-assembled, the whole of the preassembly being done under sterile conditions in the factory and the whole of the assembly being sent out as a sealed unit to where it is to be used. The bags containing the various fractions can only be separated by once for all destruction of the assembly, which is usually car ried out by a heat sealing of the tube.
This system has obvious disadvantages namely that a large number of different types and sizes of bag sets have to be assembled in the factory and cannot thereafter be altered. Also the user has to hold a large stock of different sorts of bag sets according to all the sorts of operations he may want to perform. Attempts have therefore been made to provide a kit wherein there would be provided sterile closed bags preferably only of one or two sizes and tubes preferably only of a few lengths, any of which may be joined together by the user in any desired combination. The difficulty with such a system is the need for sterility in the couplings and it is to this problem that we direct our attention.
In one proposal for dealing with this difficulty in German Auslegeschrift No. I 300635 it is proposed to have both the male and the female parts of the coupling closed by a diaphragm so that the interior of the bag or the tube as the case may be is kept sterile, the two parts of the coupling being forced together in a bath of disinfectant. An internal tube is then used to pierce the diaphragms, which in the assembled state of the coupling lie face to face, and establish a fluid path through the coupling. The coupling remains assembled only because of the tight fit together of the parts there is nothing additional holding it together. The coupling is assembled in a disinfectant bath because if microorganisms are trapped between the parts of the coupling and in particular between the diaphragms they may pass into the fluid stream or may even be driven into it by the needle when that pushes through the diaphragms. Clearly it is not desirable that one should have to do the actions of forming the coupling under the surface of a bath.
SUMMARY OF THE INVENTION In the present invention we provide a coupling for medical or research equipment, for example blood transfusion processing apparatus, wherein elements coupled together are sealed off by penetratable diaphragms one diaphragm being associated with each part of the coupling, the two diaphragms being unified together face to face by a solvent for the material of the diaphragms, and an internal means within the coupling for penetrating through the diaphragms when unified together. We find that as a result (1) micro-organisms on the respective outer faces of the diaphragms are frequently rendered non-viable by the effect of the solvent (2) that any living micro-organisms which may survive this treatment, or any other harmful contaminants, are in effect locked into the solid solution of diaphragm material which is formed between the diaphragms when they are unified by the solvent, and (3) we provide a positive means (other than a mere push fit) for holding the coupling assembled viz the unification together of the material of the diaphragms. Suitably the coupling includes male and female sleeves surrounding the diaphragm and forming a push-fit together, and the solvent for the material of the diaphragms is also a solvent for the sleeve parts and is applied between them whereby the coupling parts are unified over substantially the whole of the interacting surfaces of the sleeves and the diaphragms.
In another aspect of the invention we provide equipment for the handling of fluid which consists of at least two bags connected together by at least one tube, a coupling between the tube and. at least one of the bags including diaphragms unified by a solvent for the material of the diaphragms, the diaphragms respectively forming a barrier to access to the tubes and to the at least one of the bags, and means inside the coupling for penetrating the diaphragms when sealed together to open up a fluid path from the at least one bag to the tube.
It is an advantage of the coupling and of the system that it can be used not only for assembly by the user of a set of bags to suit his own requirements without having to work under the surface of a bath of disinfectant but can also be used within the: factory for sending out pre-assembled bag sets to those who want them, without the need for setting up in the factory a completely sterile zone for the assembly.
In the accompanying drawings:
FIG. 1 illustrates schematically a prior art arrangement of bag set,
FIG. 2 illustrates schematically a bag set embodying the present invention,
FIG. 3 shows, a male element and FIG. 4 a female element of the coupling embodying the invention, both in a diametrical section,
FIG. 5 shows, in a larger scale the elements assem bled and with diaphragms unified together, and
FIG. 6 illustrates how a fluid path is opened through the unified diaphragms.
In FIG. I of the drawing we show a prior art bag set consisting of bags a, b and c, which are interlinked respectively by tubes 1 .and 2 each having socket parts 3 on their ends fitting over plugs extending from the bags u, b, and c. The sockets 3 may be glued onto the plugs.
Each of these tubes is open ended at each end as are also the plugs of the bags so that sterility of the whole assembly is achieved only by sterilisation of the component parts and their assembly together into a sealed set all under sterile conditions. It is obvious the set cannot be dis-assembled in any way while maintaining sterility, except destructively (the method usually used being sealing-off tubes 1 or 2 by heating them and then cutting them beyond the seal).
In FIG. 2 we show elements of a bag set embodying the present invention. The bags a, b and each have at least two female socket elements 5 embodying the invention incorporating as they do each a diaphragm preventing access of micro-organisms to the interior of the bags. They will be described in more detail later. An inlet 6 to the first bag a is shown wherein for example blood from a donor may be first introduced into the bag set. This connection may be one according to the invention or may be a conventional one. Each of the bags has a plug 7 which may be one element of a coupling according to the invention or may be a known type of plug with a tear-off seal to allow access to the final contents of the bag when they are to be used. These bags may be sent out from the factory as they are in sterile and sealed condition to the user. They may be all the same size as is shown here or may be of a range of sizes which rationally should include only two sizes and not more. Since the bags are totally sealed they cannot be sterilised by ordinary heat treatment since they contain air and may contain for example anticoagulants, and they are therefore sterilised by irradiation preferably by gamma rays. Also making up part of the bag set are tubes such as 8 which have at each end a male element 9 for the coupling embodying the invention. Any of the male elements 9 will fit any of the female elements 5 on any of the bags a to c and thus the user may assemble with the bags and with the tubes he is given a set of bags which is uniquely adapted to his own requirements. Each of the male elements 9, which will be described in more detail later, contains a diaphragm sealing off the interior of the tube to the outside atmosphere and the tubes are sent out in internally sterile condition having been sterilised by irradiation again preferably by irradiation with gamma rays.
The assembly together of the male and female elements of the coupling will now be described more particularly with reference to FIGS. 3 to 6. FIG. 4 also shows how the female socket elements need not necessarily be integral with bags but may form the end fitting of a tube. It is equally possible that the male elements 9 may be integral with the bags.
The female socket part 5 has a sleeve at 10 across which is formed a diaphragm 11. The sleeve is integral with a fitting 12 for receiving the end of a tube 8' as shown in FIG. 4 or the sleeve 10 may be moulded integrally with a bag. The male element 9 is sealed off by a diaphragm 13 at the axially outer end of a sleeve 14 of which the outer diameter is such that the sleeves l4 and 10 are a tight push-fit together. A bellows construction 15 allows for relative axial movement of the sleeve 14 and another sleeve 16 of similar diameter at the other end of the bellows. This sleeve 16 constitutes a fitting in which the end of a tube such as 8 is securely fixed. In it there is also positioned an annular collar 17 which is a base for a hollow needle 18 which extends axially from that base within the sleeve 16 to Within the sleeve 14 and presents a sharp point 19 towards the diaphragm 13. When the bellows construction is in its rclaxed condition as shown in FIG. 3 the needle point 19 is clear of the diaphragm 13. As best seen in FIG. 5 the needle 18 has a pair of ports 20 near its pointed end so there may be fluid communication from that pointed end through the hollow needle and the collar 17 into the tube 8.
Preferably all the parts mentioned including the needle are formed of plastics material although the needle may of course be of metal. A preferred material for the plastics is a polyvinyl chloride material since this is cheap, readily workable and not difficult to sterilise.
A solvent particularly suitable for use with polyvinyl chloride is cyclohexanone since this has, incidentally, an appreciable sterilizing effect of its own.
To assemble the coupling together all that the user has to do is to coat the outer surface of one or preferably both diaphragms with an ample coating of a solvent for the material of those diaphragms. Obviously from the commercial point of view it would be desirable to make both diaphragms of the same material so that the widest range of solvents is available but obviously the diaphragms could be of different materials, and then a common solvent or else a solvent mixture would have to be used. The diaphragms are then pressed together face to face and left until the joint has solidifed. It would be preferable again that the material of the diaphragms should be the same as that of the sleeves l0 and 14 and then the same solvent may be also used between the touching surfaces of the sleeves and a unified joint may be formed overall to give mechanical strength to the seal. The layer 21 in FIG. 4 between the diaphragms is a solid layer of material common to each diaphragm while layer 22 is made up of material common to the sleeves l0 and 14. Any micro-organisms on the formerly exposed outer surfaces of the diaphragms are locked into the solid joint formed between the diaphragms by the layer 21 and when the needle 18 is pushed through the diaphragms so as to establish a fluid path through the coupling there is a statistically negligible risk that any viable micro-organisms will be introduced into that flow path. The needle may remain penetrating the diaphragms so that the ports 20 remain beyond the diaphragms and fluid issues from them beyond the diaphragms, or may be withdrawn again so that the hole that it has pierced through the diaphragms is used for the passage of fluid.
Obviously, the assembly step of the coupling need not be done under sterile conditions, the only precaution necessary being that a complete and adequate coating of solvent material is applied to the faces of the diaphragms.
The reduction in the risk of infection resulting from the use of this coupling and this bag system is particularly valuable when the long term storage of blood or blood fractions is being considered.
The internal penetrating elements may be attached to a bellows on as female socket element rather on a male, as shown here, or may be entirely loose within either element of the coupling (cf German Auslegeschrift No. 1300635).
What I claim is:
1. Equipment for the handling of fluid which comprises at least two bags connected together by at least one tube, a coupling between the tube and at least one of the bags including diaphragms unified by a solvent for the material of the diaphragms, the diaphragms respectively forming a barrier to access to the tubes and to the at least one of the bags, and means inside the coupling for penetrating the diaphragms when sealed together to open up a fluid path from the at least one bag to the tube.
2. Equipment as claimed in claim ll wherein the coupling includes male and female sleeves surrounding the respective diaphragms and forming a push-fit together, the coupling parts being unified over substantially the whole of the irreracting surfaces of the sleeves and the diaphragm by a resolidified region of their respective materials.
3. Equipment as claimed in claim 2 wherein the diaphragms and sleeves are all made of polyvinyl chloride.
4. Equipment as claimed in claim 2 wherein the said coupling includes an axially compressible bellows intermediate at least one tube and the diaphragms and the said means inside the coupling includes a needle mounted within the bellows with one end presented towards the diaphragm and one anchored to the end of the bellows remote from the diaphragm, whereby axial compression of the bellows can drive the needle through the diaphragm.
5. Equipment as claimed in claim 4 wherein all of the said sleeves, diaphragms and bellows are made of polyvinyl chloride.
6. A modular coupled equipment system comprising a plurality of items of medical or research equipment sealingly attached together in temporarily nonintercommunicating manner, and adapted to be made intercommunicating for use, comprising a plurality of coupled-together sets of individual coupling elements and respective items of equipment, each set comprising a coupling element and an item of equipment attached thereto, each coupling element comprising a housing, and a coupling passage extending through the housing and open at each end, the coupling element being attached to the item of equipment so that one open end of the coupling passage communicates with the item of equipment; a penetrable diaphragm disposed across the coupling passage and sealing off the passage from flow therethrough until penetrated; the housing of each coupling element at the other open end of the passage being shaped to sealingly interconnect with the coupling element of another set to which it is sealingly attached, the coupling passages of interconnected coupling elements being aligned to form an intercommunicating through passage extending to each item of equipment closed off by the diaphragm in the coupling passages; the diaphragms of adjacent coupling elements being in abutting relation and united by an intermediate layer of interdiffused diaphragm material, and disposed in at least one of each two adjacent coupling elements at least one internal means for each pair of diaphragms for penetration through the diaphragms thereof to provide intercommunication between the coupled items of equipment via the passage.
7. A modular coupled equipment system according to claim 6 wherein the interconnected coupling components comprise interconnected male and female sleeves surrounding the respective diaphragms and forming a pushfit together, the coupling components being united over substantially the whole of the abutting surfaces of the sleeves and the diaphragms by interdiffusion of diaphragm material.
8. A modular coupled equipment system according to claim 6 wherein the diaphragms and the sleeves are all made of plastic material.
9. A modular coupled equipment system according to claim 8 wherein the plastic material is polyvinyl chloride.
10. A modular coupled equipment system according to claim 6 wherein the diaphragms are made of plastic material.
11. A modular coupled equipment system according to claim 6 wherein the said internal means includes an axially compressible bellows, a needle mounted within the bellows with one end presented towards the diaphragm and one anchored to the end of the bellows remote from the diaphragm, whereby axial compression of the bellows can drive the needle through the diaphragm.
12. A modular coupled equipment system according to claim 11 wherein all of the said sleeves, diaphragms and bellows are made of polyvinyl chloride.
13. A modular coupled equip'ment system according to claim 11 wherein the needle is hollow and has fluid ports opening to its outside near the end presented towards the diaphragm.
l4. Coupling elements for a coupling according to claim 6.
15. Method of coupling together respective coupling elements on respective items of equipment to be coupled together, each coupling element having a penetratable diaphragm preventing access to the interior of the item from the outside, and at least one of the elements having internal means for penetrating through the diaphragms, which comprises applying a solvent to the exposed faces of the diaphragms to form a solution of their material at the said faces and bringing the said faces into face-to-face contact whereby to unify the diaphragms by a layer of their material.
16. Method according to claim 15 wherein the said material is polyvinyl chloride and the solvent is cyclo-
Claims (16)
1. Equipment for the handling of fluid which comprises at least two bags connected together by at least one tube, a coupling between the tube and at least one of the bags including diaphragms unified by a solvent for the material of the diaphragms, the diaphragms respectively forming a barrier to access to the tubes and to the at least one of the bags, and means inside the coupling for penetrating the diaphragms when sealed together to open up a fluid path from the at least one bag to the tube.
2. Equipment as claimed in claim 1 wherein the coupling includes male and female sleeves surrounding the respective diaphragms and forming a push-fit together, the coupling parts being unified over substantially the whole of the interacting surfaces of the sleeves and the diaphragm by a resolidified region of their respective materials.
3. Equipment as claimed in claim 2 wherein the diaphragms and sleeves are all made of polyvinyl chloride.
4. Equipment as Claimed in claim 2 wherein the said coupling includes an axially compressible bellows intermediate at least one tube and the diaphragms and the said means inside the coupling includes a needle mounted within the bellows with one end presented towards the diaphragm and one anchored to the end of the bellows remote from the diaphragm, whereby axial compression of the bellows can drive the needle through the diaphragm.
5. Equipment as claimed in claim 4 wherein all of the said sleeves, diaphragms and bellows are made of polyvinyl chloride.
6. A modular coupled equipment system comprising a plurality of items of medical or research equipment sealingly attached together in temporarily nonintercommunicating manner, and adapted to be made intercommunicating for use, comprising a plurality of coupled-together sets of individual coupling elements and respective items of equipment, each set comprising a coupling element and an item of equipment attached thereto, each coupling element comprising a housing, and a coupling passage extending through the housing and open at each end, the coupling element being attached to the item of equipment so that one open end of the coupling passage communicates with the item of equipment; a penetrable diaphragm disposed across the coupling passage and sealing off the passage from flow therethrough until penetrated; the housing of each coupling element at the other open end of the passage being shaped to sealingly interconnect with the coupling element of another set to which it is sealingly attached, the coupling passages of interconnected coupling elements being aligned to form an intercommunicating through passage extending to each item of equipment closed off by the diaphragm in the coupling passages; the diaphragms of adjacent coupling elements being in abutting relation and united by an intermediate layer of interdiffused diaphragm material, and disposed in at least one of each two adjacent coupling elements at least one internal means for each pair of diaphragms for penetration through the diaphragms thereof to provide intercommunication between the coupled items of equipment via the passage.
7. A modular coupled equipment system according to claim 6 wherein the interconnected coupling components comprise interconnected male and female sleeves surrounding the respective diaphragms and forming a push-fit together, the coupling components being united over substantially the whole of the abutting surfaces of the sleeves and the diaphragms by interdiffusion of diaphragm material.
8. A modular coupled equipment system according to claim 6 wherein the diaphragms and the sleeves are all made of plastic material.
9. A modular coupled equipment system according to claim 8 wherein the plastic material is polyvinyl chloride.
10. A modular coupled equipment system according to claim 6 wherein the diaphragms are made of plastic material.
11. A modular coupled equipment system according to claim 6 wherein the said internal means includes an axially compressible bellows, a needle mounted within the bellows with one end presented towards the diaphragm and one anchored to the end of the bellows remote from the diaphragm, whereby axial compression of the bellows can drive the needle through the diaphragm.
12. A modular coupled equipment system according to claim 11 wherein all of the said sleeves, diaphragms and bellows are made of polyvinyl chloride.
13. A modular coupled equipment system according to claim 11 wherein the needle is hollow and has fluid ports opening to its outside near the end presented towards the diaphragm.
14. Coupling elements for a coupling according to claim 6.
15. Method of coupling together respective coupling elements on respective items of equipment to be coupled together, each coupling element having a penetratable diaphragm preventing access to the interior of the item from the outside, and at least one of the elements having internal means for penetrating through the diaphragms, which comprises applYing a solvent to the exposed faces of the diaphragms to form a solution of their material at the said faces and bringing the said faces into face-to-face contact whereby to unify the diaphragms by a layer of their material.
16. Method according to claim 15 wherein the said material is polyvinyl chloride and the solvent is cyclohexanone.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB2952472A GB1428391A (en) | 1972-06-23 | 1972-06-23 | Couplings |
Publications (1)
Publication Number | Publication Date |
---|---|
US3902489A true US3902489A (en) | 1975-09-02 |
Family
ID=10292917
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US372848A Expired - Lifetime US3902489A (en) | 1972-06-23 | 1973-06-22 | Couplings |
Country Status (4)
Country | Link |
---|---|
US (1) | US3902489A (en) |
DE (1) | DE2331687C3 (en) |
FR (1) | FR2202252B1 (en) |
GB (1) | GB1428391A (en) |
Cited By (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3986508A (en) * | 1973-08-22 | 1976-10-19 | Abcor, Inc. | Sterilizable, medical connector for blood processing |
US4004586A (en) * | 1975-03-12 | 1977-01-25 | Baxter Travenol Laboratories, Inc. | Method and apparatus for sealed, sterile connection |
US4019512A (en) * | 1975-12-04 | 1977-04-26 | Tenczar Francis J | Adhesively activated sterile connector |
US4022205A (en) * | 1973-11-05 | 1977-05-10 | Tenczar Francis J | Fluid connectors |
US4030494A (en) * | 1973-11-05 | 1977-06-21 | Francis Tenczar | Fluid connectors |
US4058363A (en) * | 1974-01-15 | 1977-11-15 | Silbert Jerome A | Method and apparatus for sterile handling of fluids |
US4162566A (en) * | 1977-12-12 | 1979-07-31 | General Electric Company | Method and coupling for severing and rejoining sealed tubing |
US4219221A (en) * | 1979-02-26 | 1980-08-26 | General Electric Company | Coupling for rejoining sealed tubing |
US4306976A (en) * | 1979-05-25 | 1981-12-22 | Bieffe S.P.A. | Method and device for ambulatory peritoneal dialysis |
US4334551A (en) * | 1979-04-30 | 1982-06-15 | Becton Dickinson & Company | Connector |
US4351328A (en) * | 1980-03-27 | 1982-09-28 | Sontek Industries, Inc. | Simultaneous respiration and endotracheal suctioning of a critically ill patient |
US4368729A (en) * | 1980-10-14 | 1983-01-18 | Baxter Travenol Laboratories, Inc. | Aseptic system for total parenteral nutrition and the like |
US4386933A (en) * | 1981-05-21 | 1983-06-07 | Sanchez Enrique R | Sterile adapter for use in blood transfers |
US4392850A (en) * | 1981-11-23 | 1983-07-12 | Abbott Laboratories | In-line transfer unit |
US4392851A (en) * | 1981-11-23 | 1983-07-12 | Abbott Laboratories | In-line transfer unit |
WO1983002395A1 (en) * | 1982-01-11 | 1983-07-21 | Baxter Travenol Lab | Continuous ambulatory peritoneal dialysis clamping system |
US4552277A (en) * | 1984-06-04 | 1985-11-12 | Richardson Robert D | Protective shield device for use with medicine vial and the like |
USRE32056E (en) * | 1977-10-19 | 1985-12-24 | Baxter Travenol Laboratories, Inc. | Method of forming a connection between two sealed conduits using radiant energy |
US4576313A (en) * | 1980-05-08 | 1986-03-18 | Steiner Corporation | Fluid refill pouch and dispenser |
EP0096062B1 (en) * | 1981-12-14 | 1986-06-04 | Ncr Corporation | Non-volatile semiconductor memory device and manufacturing method therefor |
EP0217055A1 (en) * | 1985-07-31 | 1987-04-08 | Kawasumi Laboratories, Inc. | A connector for plasmapheresis bag |
US4869398A (en) * | 1986-11-25 | 1989-09-26 | Life Technologies, Inc. | Liquid container delivery and storage system |
US4919658A (en) * | 1987-06-05 | 1990-04-24 | Institute Municipal D'assistencia Sanitaria | Connection for catheters, perfusion units and flasks of liquid to be perfused |
US5117875A (en) * | 1988-06-02 | 1992-06-02 | Piero Marrucchi | Method and device for manipulating and transferring products between confined volumes |
US5176673A (en) * | 1988-06-02 | 1993-01-05 | Piero Marrucchi | Method and device for manipulating and transferring products between confined volumes |
US5176415A (en) * | 1990-08-16 | 1993-01-05 | Choksi Pradip V | Taper fitting with protective skirt |
US5304192A (en) * | 1992-01-16 | 1994-04-19 | Sherwood Medical Company | Lancet with locking cover |
US5393101A (en) * | 1992-10-02 | 1995-02-28 | Pall Corporation | Connector assembly |
US5575779A (en) * | 1994-12-30 | 1996-11-19 | Namic U.S.A. Corporation | Liquid regulator and method of use |
US5584825A (en) * | 1994-12-01 | 1996-12-17 | Isolyser Co., Inc. | Closure delivery system |
US5810398A (en) * | 1992-10-02 | 1998-09-22 | Pall Corporation | Fluid delivery systems and methods and assemblies for making connections |
US6394992B1 (en) * | 1997-07-14 | 2002-05-28 | Arom Pak International Ab | Aseptic connection device |
US6539248B1 (en) | 1993-07-14 | 2003-03-25 | Abbott Laboratories | Dye management system including an administration set with an in line burette |
US6655655B1 (en) | 1997-05-09 | 2003-12-02 | Pall Corporation | Connector assemblies, fluid systems, and methods for making a connection |
US20040034328A1 (en) * | 2000-04-06 | 2004-02-19 | Peter Unger | Sterile coupling |
US20050017503A1 (en) * | 2003-07-23 | 2005-01-27 | Garry Tsaur | Connector with frangible seal |
US20050154368A1 (en) * | 2003-11-21 | 2005-07-14 | Vasogen Ireland Limited | Medical material handling systems |
EP1415635A3 (en) * | 1998-09-15 | 2005-07-27 | Baxter International Inc. | Sliding reconstitution device for a diluent container |
US20060111658A1 (en) * | 1999-07-29 | 2006-05-25 | Jean-Marie Mathias | Sampling tube holder for blood sampling system |
US7074216B2 (en) | 1998-09-15 | 2006-07-11 | Baxter International Inc. | Sliding reconstitution device for a diluent container |
US20080086087A1 (en) * | 2004-04-16 | 2008-04-10 | Spohn Michael A | Fluid delivery system including a fluid path set with sterile check valve connector |
US7425209B2 (en) | 1998-09-15 | 2008-09-16 | Baxter International Inc. | Sliding reconstitution device for a diluent container |
US7611503B2 (en) | 2004-04-16 | 2009-11-03 | Medrad, Inc. | Fluid delivery system, fluid path set, sterile connector and improved drip chamber and pressure isolation mechanism |
US20100010413A1 (en) * | 2008-07-09 | 2010-01-14 | Loiterman David A | Needle for Subcutaneous Port |
US20110092828A1 (en) * | 2004-04-16 | 2011-04-21 | Spohn Michael A | Fluid Delivery System, Fluid Path Set, and Pressure Isolation Mechanism with Hemodynamic Pressure Dampening Correction |
US8454059B2 (en) | 2010-09-13 | 2013-06-04 | Pall Corporation | Connector assemblies, fluid systems including connector assemblies, and procedures for making fluid connections |
WO2013136889A1 (en) * | 2012-03-12 | 2013-09-19 | テルモ株式会社 | Blood-flow-path connecting device and blood-bag system |
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US4195632A (en) * | 1978-05-03 | 1980-04-01 | Cutter Laboratories, Inc. | Fluid flow valve |
DE2853635A1 (en) * | 1978-12-08 | 1980-06-19 | Affeld Klaus Prof Dr | Coupling for joining sterile hoses - with telescopic protective sleeves beyond length of hose contact ends |
US4439188A (en) * | 1980-09-15 | 1984-03-27 | Baxter Travenol Laboratories, Inc. | Tube connector |
US4412834A (en) * | 1981-06-05 | 1983-11-01 | Baxter Travenol Laboratories | Antimicrobial ultraviolet irradiation of connector for continuous ambulatory peritoneal dialysis |
EP0165926B1 (en) * | 1983-05-20 | 1990-10-24 | Bengt Gustavsson | A device for transferring a substance |
US4611643A (en) * | 1983-11-21 | 1986-09-16 | Baxter Travenol Laboratories, Inc. | Interlocking fluid transfer device and resulting assembly |
IT1175783B (en) * | 1984-03-06 | 1987-07-15 | Bieffe Spa | SYSTEM AND DEVICE FOR DIALYSIS |
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DE1091292B (en) * | 1956-10-05 | 1960-10-20 | Dr Med Habil Jakob Clemens | Protection device for the use of needles |
DE1300635B (en) * | 1964-09-07 | 1969-08-07 | Dr Med Karl Friedrich | Sterile line connection for the flow of transfusion or infusion fluids |
FR2104036A5 (en) * | 1971-08-06 | 1972-04-14 | Christensen Borge |
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- 1973-06-22 FR FR7322942A patent/FR2202252B1/fr not_active Expired
- 1973-06-22 US US372848A patent/US3902489A/en not_active Expired - Lifetime
- 1973-06-22 DE DE2331687A patent/DE2331687C3/en not_active Expired
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US2847995A (en) * | 1954-08-23 | 1958-08-19 | Becton Dickinson Co | Transfusion needle sheath |
US2933333A (en) * | 1955-09-26 | 1960-04-19 | Crane Co | Pipe coupling |
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Cited By (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3986508A (en) * | 1973-08-22 | 1976-10-19 | Abcor, Inc. | Sterilizable, medical connector for blood processing |
US4022205A (en) * | 1973-11-05 | 1977-05-10 | Tenczar Francis J | Fluid connectors |
US4030494A (en) * | 1973-11-05 | 1977-06-21 | Francis Tenczar | Fluid connectors |
US4058363A (en) * | 1974-01-15 | 1977-11-15 | Silbert Jerome A | Method and apparatus for sterile handling of fluids |
US4004586A (en) * | 1975-03-12 | 1977-01-25 | Baxter Travenol Laboratories, Inc. | Method and apparatus for sealed, sterile connection |
US4019512A (en) * | 1975-12-04 | 1977-04-26 | Tenczar Francis J | Adhesively activated sterile connector |
USRE32056E (en) * | 1977-10-19 | 1985-12-24 | Baxter Travenol Laboratories, Inc. | Method of forming a connection between two sealed conduits using radiant energy |
US4162566A (en) * | 1977-12-12 | 1979-07-31 | General Electric Company | Method and coupling for severing and rejoining sealed tubing |
US4219221A (en) * | 1979-02-26 | 1980-08-26 | General Electric Company | Coupling for rejoining sealed tubing |
US4334551A (en) * | 1979-04-30 | 1982-06-15 | Becton Dickinson & Company | Connector |
US4306976A (en) * | 1979-05-25 | 1981-12-22 | Bieffe S.P.A. | Method and device for ambulatory peritoneal dialysis |
US4351328A (en) * | 1980-03-27 | 1982-09-28 | Sontek Industries, Inc. | Simultaneous respiration and endotracheal suctioning of a critically ill patient |
US4576313A (en) * | 1980-05-08 | 1986-03-18 | Steiner Corporation | Fluid refill pouch and dispenser |
US4368729A (en) * | 1980-10-14 | 1983-01-18 | Baxter Travenol Laboratories, Inc. | Aseptic system for total parenteral nutrition and the like |
US4386933A (en) * | 1981-05-21 | 1983-06-07 | Sanchez Enrique R | Sterile adapter for use in blood transfers |
US4392850A (en) * | 1981-11-23 | 1983-07-12 | Abbott Laboratories | In-line transfer unit |
US4392851A (en) * | 1981-11-23 | 1983-07-12 | Abbott Laboratories | In-line transfer unit |
EP0096062B1 (en) * | 1981-12-14 | 1986-06-04 | Ncr Corporation | Non-volatile semiconductor memory device and manufacturing method therefor |
WO1983002395A1 (en) * | 1982-01-11 | 1983-07-21 | Baxter Travenol Lab | Continuous ambulatory peritoneal dialysis clamping system |
US4473369A (en) * | 1982-01-11 | 1984-09-25 | Baxter Travenol Laboratories, Inc. | Continuous ambulatory peritoneal dialysis clamping system |
US4552277A (en) * | 1984-06-04 | 1985-11-12 | Richardson Robert D | Protective shield device for use with medicine vial and the like |
EP0217055A1 (en) * | 1985-07-31 | 1987-04-08 | Kawasumi Laboratories, Inc. | A connector for plasmapheresis bag |
US4869398A (en) * | 1986-11-25 | 1989-09-26 | Life Technologies, Inc. | Liquid container delivery and storage system |
US4919658A (en) * | 1987-06-05 | 1990-04-24 | Institute Municipal D'assistencia Sanitaria | Connection for catheters, perfusion units and flasks of liquid to be perfused |
US5117875A (en) * | 1988-06-02 | 1992-06-02 | Piero Marrucchi | Method and device for manipulating and transferring products between confined volumes |
US5176673A (en) * | 1988-06-02 | 1993-01-05 | Piero Marrucchi | Method and device for manipulating and transferring products between confined volumes |
US5176415A (en) * | 1990-08-16 | 1993-01-05 | Choksi Pradip V | Taper fitting with protective skirt |
US5286067A (en) * | 1990-08-16 | 1994-02-15 | Pradip Choksi | Taper fitting with protective skirt |
US5304192A (en) * | 1992-01-16 | 1994-04-19 | Sherwood Medical Company | Lancet with locking cover |
US5868433A (en) * | 1992-10-02 | 1999-02-09 | Pall Corporation | Connector assembly |
US5393101A (en) * | 1992-10-02 | 1995-02-28 | Pall Corporation | Connector assembly |
US6536805B2 (en) | 1992-10-02 | 2003-03-25 | Pall Corporation | Fluid delivery systems and methods and assemblies for making connections |
US6341802B1 (en) | 1992-10-02 | 2002-01-29 | Pall Corporation | Fluid delivery systems and methods and assemblies for making connections |
US5810398A (en) * | 1992-10-02 | 1998-09-22 | Pall Corporation | Fluid delivery systems and methods and assemblies for making connections |
US5324302A (en) * | 1992-10-13 | 1994-06-28 | Sherwood Medical Company | Lancet with locking cover |
US6539248B1 (en) | 1993-07-14 | 2003-03-25 | Abbott Laboratories | Dye management system including an administration set with an in line burette |
US5672162A (en) * | 1994-12-01 | 1997-09-30 | Isolyser Co., Inc. | Closure delivery system |
US5584825A (en) * | 1994-12-01 | 1996-12-17 | Isolyser Co., Inc. | Closure delivery system |
US5575779A (en) * | 1994-12-30 | 1996-11-19 | Namic U.S.A. Corporation | Liquid regulator and method of use |
US6655655B1 (en) | 1997-05-09 | 2003-12-02 | Pall Corporation | Connector assemblies, fluid systems, and methods for making a connection |
US6394992B1 (en) * | 1997-07-14 | 2002-05-28 | Arom Pak International Ab | Aseptic connection device |
US7425209B2 (en) | 1998-09-15 | 2008-09-16 | Baxter International Inc. | Sliding reconstitution device for a diluent container |
US8226627B2 (en) | 1998-09-15 | 2012-07-24 | Baxter International Inc. | Reconstitution assembly, locking device and method for a diluent container |
US7074216B2 (en) | 1998-09-15 | 2006-07-11 | Baxter International Inc. | Sliding reconstitution device for a diluent container |
EP1415635A3 (en) * | 1998-09-15 | 2005-07-27 | Baxter International Inc. | Sliding reconstitution device for a diluent container |
US20060111658A1 (en) * | 1999-07-29 | 2006-05-25 | Jean-Marie Mathias | Sampling tube holder for blood sampling system |
US7097209B2 (en) * | 2000-04-06 | 2006-08-29 | Gambro Inc. | Sterile coupling |
US20040034328A1 (en) * | 2000-04-06 | 2004-02-19 | Peter Unger | Sterile coupling |
US20050017503A1 (en) * | 2003-07-23 | 2005-01-27 | Garry Tsaur | Connector with frangible seal |
US20050154368A1 (en) * | 2003-11-21 | 2005-07-14 | Vasogen Ireland Limited | Medical material handling systems |
US7611503B2 (en) | 2004-04-16 | 2009-11-03 | Medrad, Inc. | Fluid delivery system, fluid path set, sterile connector and improved drip chamber and pressure isolation mechanism |
US20110092828A1 (en) * | 2004-04-16 | 2011-04-21 | Spohn Michael A | Fluid Delivery System, Fluid Path Set, and Pressure Isolation Mechanism with Hemodynamic Pressure Dampening Correction |
US20080086087A1 (en) * | 2004-04-16 | 2008-04-10 | Spohn Michael A | Fluid delivery system including a fluid path set with sterile check valve connector |
US8540698B2 (en) | 2004-04-16 | 2013-09-24 | Medrad, Inc. | Fluid delivery system including a fluid path set and a check valve connector |
US8992489B2 (en) | 2004-04-16 | 2015-03-31 | Bayer Medical Care Inc. | Fluid delivery system, fluid path set, and pressure isolation mechanism with hemodynamic pressure dampening correction |
US9895527B2 (en) | 2004-04-16 | 2018-02-20 | Bayer Healthcare Llc | Fluid delivery system, fluid path set, and pressure isolation mechanism with hemodynamic pressure dampening correction |
US20100010413A1 (en) * | 2008-07-09 | 2010-01-14 | Loiterman David A | Needle for Subcutaneous Port |
US8454059B2 (en) | 2010-09-13 | 2013-06-04 | Pall Corporation | Connector assemblies, fluid systems including connector assemblies, and procedures for making fluid connections |
WO2013136889A1 (en) * | 2012-03-12 | 2013-09-19 | テルモ株式会社 | Blood-flow-path connecting device and blood-bag system |
Also Published As
Publication number | Publication date |
---|---|
GB1428391A (en) | 1976-03-17 |
FR2202252A1 (en) | 1974-05-03 |
FR2202252B1 (en) | 1978-12-08 |
DE2331687C3 (en) | 1978-05-11 |
DE2331687B2 (en) | 1977-08-25 |
DE2331687A1 (en) | 1974-01-10 |
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