US3788327A - Surgical implant device - Google Patents

Surgical implant device Download PDF

Info

Publication number
US3788327A
US3788327A US00129384A US3788327DA US3788327A US 3788327 A US3788327 A US 3788327A US 00129384 A US00129384 A US 00129384A US 3788327D A US3788327D A US 3788327DA US 3788327 A US3788327 A US 3788327A
Authority
US
United States
Prior art keywords
flange
passageway
eye
valve
shank
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US00129384A
Inventor
H Donowitz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
HARA W
HARA W US
Original Assignee
HARA W
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by HARA W filed Critical HARA W
Application granted granted Critical
Publication of US3788327A publication Critical patent/US3788327A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/07Endoradiosondes
    • A61B5/076Permanent implantations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/16Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for measuring intraocular pressure, e.g. tonometers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007Methods or devices for eye surgery
    • A61F9/00781Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment

Definitions

  • Disclosed implant device includes a valve and conduit means for controlling the intra-occular pressure build up in a diseased eye.
  • This invention relates generally to surgical devices and more particularly to a surgical device to be implanted in an eye for controlling intra-occular pressure, as, for example, in a glaucoma diseased eye wherein there is an increased pressure built up within the eye from the accumulation of fluid.
  • aqueous humor which constantly forms and enters portions of the eye globe known as the anterior and posterior chambers, are balanced by those fluids which leave the eye by drainage through the canal of Schlemm.
  • glaucoma for example, more fluid is secreted than is discharged, which results in an increase in intra-occular pressure, causing pain, interference with vision, and eventual blindness.
  • this fluid imbalance is usually due to a blockage of the canal of Schlemm from a change in the character of the filtering or drainage tissues or a collapse of the angle of the anterior chamber.
  • One such device includes, for example, an elongated tubular section curved to the same radius as an eye and an attached right angled section including a bore and adapted for insertion into a hole surgically drilled in an eye so as to provide for the drainage of fluid through the device into the retrobulbar space behind the eye.
  • the implant device of the present invention includes an elongated shank member have a passageway axially extending therethrough and mounting a valve therein to normally provide for closure of the passageway, the valve opening in response to a predetermined pressure differential within the passageway.
  • a flange is provided on one end of the shank member to anchor the implant device.
  • Means are also provided on the shank member for insuring retention of the device in the eye.
  • FIG. 1 is a vertical section of a human eye showing the device of the present invention implanted therein;
  • FIG. 2 is a perspective view of the implant device of the invention
  • FIG. 3 is a top view of the device of FIG. 2;
  • FIG. 4 is an enlarged front sectional view taken along the lines 4-4 of FIG. 3;
  • FIG. 5 is an enlarged section of the valve area shown in FIG. 4.
  • FIG. 6 is a modified front sectional view of the flange and upper shank portion of the device.
  • FIG. 1 there is illustrated a human eyeball which includes the lens 10, posterior chamber 12, anterior chamber 14, iris 16, sclera 18, canal of Schlemm 20, cornea 22, and the conjunctiva 24 of the eye.
  • the device 26 of the present invention when implanted in the eye preferably extends through the cornea 22 and into the anterior chamber 14 of the eye.
  • an implant device in accordance with the present invention comprises an elongated body or shank portion 28 generally cylindrical in shape, slightly tapered, and having a bore or passageway 30 extending axially therethrough.
  • One end 32 of the shank portion 28 is capped by an integrally formed circular flange 34 with the passageway opening therethrough.
  • the other end of the passageway opens through the bottom portion 36 of the shank 28 which has an obliquely slanted end face 38 to facilitate implantation of the device 26 into an eye as will hereinafter be described.
  • the flange portion 34 is preferably slanted or obliquely positioned relative to the longitudinal axis of the shank portion and has its top and bottom surfaces 40 and 42 arcuately contoured so as to conform generally to the cornea or other portion of the eyeball surface into which the device is to be implanted.
  • the flange portion 34 being seated thereon thus serves to prevent the implant device from being submerged into the eye after insertion.
  • a plurality of apertures 44 In spaced array along the periphery of the flange portion 34 are a plurality of apertures 44. Spaced downwardly from the flange portion 34 and extending up and outwardly from the outside surface of the shank portion 28 are a pair of integrally formed projections or barbs 46 which may serve as a means for retaining the device in the eye after implantation. It is important that the barbs 46 be spaced sufficiently beneath the underside of the flange so as to accommodate therebetween the wall thickness of the cornea or other portion of the eyeball receiving the implant device, or alternately be spaced so as to lock within the stroma or mid point of the cornea.
  • a valve means 48 is provided and seated within the shank passageway 30 so as to normally provide for a closure of the passageway, and for opening in response to a predetermined pressure differential within the passageway and on opposing portions of the valve means.
  • a preferred valve means includes a pair of opposing flexible web or reed-like members 50 and 52 formed integral with and extending out from the inside wall surfaces bounding the passageway 30 and normally abutting one another so as to close off the passageway and inhibit any flow therethrough.
  • the valve is formed in the shank portion at a point intermediate the ends thereof.
  • the abutting engagement of the reed members 50 and 52 is such that the valve functions in a one-way manner by allowing for the upward deflection of the reed members 50 and 52 in response to the presence of a predetermined increase in pressure exerted on the bottom surfaces 54 and 56 (as viewed in the Figures) of the reed members relative to the pressure exerted on the top surfaces 58 and 60 of the reed members.
  • the material chosen must be inert and nontoxic. Also it is desirable that the material be somewhat resilient so as to allow for an integral formation within the internal passageway of a one-way valve.
  • One material that has proved satisfactory for this purpose is manufactured by the DuPont Company, under the trade name Teflon.
  • the double reed valve may be fabricated, for example, by machining the shank portion bore from both ends to provide a diaphragm like membrane between the bored end portions. The membrane is then pierced to create a double reed type valve.
  • Piercing of the membrane is from the bottom end of the bore such that the reed valve operates to open only toward the top or flange end of the shank, thereby functioning as a one-way type valve.
  • the valve is thus dependent on the memory retention or resiliency of the material of which it is formed, in addition to the back pressure exerted on the flange side of the valve, to return to its seat or closed position.
  • the pressure differential or program setting to which the valve openly responds is determined by the thickness of the membrane forming the reed members, the general characteristics and resiliency of the material used in fabricating the device as well as the size of the bore opening or passageway.
  • a double reed type valve Advantages in the use of a double reed type valve are the relative ease with which the response threshold point of the valve can be controlled, i.e., the point at which the valve responds to a pressure difference. Also the greater the pressure difference, the more the valve flaps or reed members will deflect to open the passageway and allow for fluid discharge, the valve opening being directly proportional to the applied pressure differential.
  • valve means as, for example, a ball valve, single reed valve or a spring valve may be used in the construction of the device of the present invention.
  • the device of the present invention may be implanted into and through the cornea 22 and into communication with the anterior chamber 14, the implantation preferably being made in the upper portion of the cornea just beneath the canal of Schlemm 20.
  • the shank portion of the implant device is preferably provided with a tapered outside contour as shown in the Figures so as to facilitate easy insertion, either directly or through a prepared tract into the eye.
  • a hyperdermic needle-like instrument is preferably used to first pierce the cornea to provide a tract for receiving the device.
  • the cornea is a desirable area of the eye for receiving the device since the inherent pliable nature of the cornea will permit the easy implantation of the device and also enhance a sealing around the shank portion of the device after it is received in the eye.
  • the device can be inserted directly into the cornea without the aid of a tract. Also, other areas of the eyeball may be used for implantation of the device of the present invention.
  • the device flange portion 34 Upon implantation, the device flange portion 34 will seat on the cornea or other area of the eye receiving the device, while the barb projections 46 lock against the underside of the receiving tissue for retaining the device in the eye.
  • the barb projections may be spaced so as to lock within the stroma of the cornea, or mid area of the receiving tissue.
  • the flange portion 34 of the implant device may be provided with a plurality of apertures 44 spaced around the periphery thereof. These flange apertures 44 may serve two functions. When the device is implanted in the cornea portion of the eye, the apertures allow the eye tears to wash and provide for the normal irrigation of the cornea area under the flange. Where the implant is in another area of the eye, as, for example, through the sclera, the flange apertures may be used to anchor the device in the eye with the aid of sutures.
  • the pressure of the top surfaces 58 and 60 of the valve i.e., the discharge end of the valve, which is exposed to the outside of the eye after implantation of the device, is at or about the atmospheric pressure.
  • the pressure inside the eye globe, and more particularly in the anterior and posterior chambers thereof is understood to be between 15 and 25 millimeters (mm.) of mercury above the atmospheric pressure.
  • a point is reached, i.e., the threshold or program setting of the valve, wherein the valve will open to allow the passage of fluid from the anterior chamber through the shank bore of passageway to the outside of the eye wherein it mingles with existing eye tears and is disposed of in the normal manner.
  • the increased intra-occular pressure built up is in this way controlled.
  • the pressure point at which the valve may be programmed to open may, for example, be between 20 and 25 mm. of mercury.
  • valve membrane When the pressure difference on both sides of the valve membrane, i.e., the top and bottom surfaces of the reed members, decreases to a preset level substantially equal to the aforementioned program setting, the valve closes.
  • the rate and degree of valve opening is a function of the amount of the intra-occular pressure and consequently the pressures exerted on the bottom surfaces of the valve reed members.
  • the valve serves to regulate the flow of fluid through the shank passageway in direct proportion to the degree of excessive intra-occular pressure built up in the eye. Since the intraoccular pressure will be changing as the valve allows for the discharge of fluid, the valve reeds will tend to substantially open and close or flutter in operation.
  • the circulation of the aqueous is enhanced against the posterior part of the cornea. This is desirable since the aqueous normally provides a means of carrying nourishment to the cornea and also for the disposal of waste matter.
  • a device in accordance with the invention has been constructed with an operating valve as abovedescribed and with a shank length of approxiamtely 2.5 mm., a bore diameter of approximately 0.5 mm., and a flange portion 2 mm. in diameter.
  • the relatively small size of the device will minimize friction between an eyelid and the device when implanted. Also, during implantation of the device and because of its size, there will be substantially no tissue of fluid loss.
  • FIG. 6 there is illustrated a fragmentary sectional view showing a modified embodiment of the flange and retaining means portons of the implant device of the present invention.
  • the upper end of the shank portion 28 is necked down as shown so as to provide a step or shelf 62 which functions to help retain the implant device in an eye in a manner similar to that of the heretofore described barb projections shown in FIG. 4.
  • the top surface 40 of the flange portion 34 is provided with an integrally formed annular rib or ridge member 64. With the device implanted in an area of the eye other than the cornea, and more particularly the sclera, the ridge 64 will serve to discourage the formation of cicatrix or scar tissue over the flange opening of the passageway.
  • the device herein described may be easily implanted in a human eye, provides a minimum of discomfort to the recipient, and functions in a simple, eyt effective manner to control an intraoccular pressure build up. It will also be clear that variations in the details of consruction which are specifically illustrated and described may be resorted to without departing from the scope of the invention.
  • a surgical implant device for implantation in an eye comprising:
  • an elongated shank member generally tubular in shape and having a flange surrounding one end thereof, said shank member being provided with a passageway opening in said one end through said flange and axially extending through said shank and out the other end thereof;
  • valve means seated within said passageway and normally positioned to provide for closure thereof, said valve means opening in response to a predetermined pressure differential within said passageway and on opposing sides of the valve;
  • said retention means includes a plurality of spaced projections formed on the outside surface of said shank member and angled upwardly toward said flange portion.
  • said flange includes a ridge member integrally formed on the surface thereof opposite said shank and concentric with the opening therein,
  • valve means includes a pair of opposing reed members integrally formed within said passageway and extending thereacross so as to normally close off said passageway.
  • flange includes a plurality of openings spaced around the periphery thereof.
  • a surgical device for implantation in an eye comprising:
  • a flange portion having top and bottom surfaces and a central aperture therein;
  • pressure sensitive valve means seated within said passageway and normally positioned to provide for closure of said passageway, said valve means opening in response to a predetermined pressure differential within said passageway and on opposing sides of the valve;
  • said flange portion being generally circular in shape and overlying said body portion in an inclined position relative to the longitudinal axis of said body portion, said flange including a plurality of apertures spaced along the periphery thereof; and means integrally formed on and displaced along said body portion beneath said flange portion for the retention of said device in an eye, said retention means including a plurality of spaced projections formed along the outside surface of said body portion and angled upwardly toward said flange portion.

Abstract

Disclosed implant device includes a valve and conduit means for controlling the intra-occular pressure build up in a diseased eye.

Description

United States Patent [1 1 Donowitz et a1.
[ Jan. 29, 1974 SURGICAL IMPLANT DEVICE [76] Inventors: Howard Donowitz, Box 218, R.D.
No. 1; William J. OHara, 23 Hampton Dr., both of Freehold, NJ. 07728 [22] Filed: Mar. 30, 1971 [21] Appl. No.: 129,384
[52] U.S. Cl 128/350 R [51] Int. Cl. A61m 27/00, A61m 25/00 [58] Field of Search 128/348, 350 R, 350 V [56] References Cited UNITED STATES PATENTS 2,867,213 1/1959 Thomas, Jr. 128/350 V 3,333,588 8/1967 Schulte 128/350 R 274,447 3/1883 Kennish 128/348 UX 733,152 7/1903 Chisholm 128/350 V 1,388,172 8/1921 Craddock 128/348 3,159,161 12/1964 Ness 128/350 R 3,421,509 1/1969 Fiore 128/349 R 6/1856 Peale 3/D1G. 3
OTHER PUBLICATIONS Teflon Armstrong Beveled Drain Tube, Advertisement of Richards Mfg. Co., Memphis, Tenn. Copyright Primary Examiner-Channing L. Pace Attorney, Agent, or Firm-Leonard R. Fellen ABSTRACT Disclosed implant device includes a valve and conduit means for controlling the intra-occular pressure build up in a diseased eye.
7 Claims, 6 Drawing Figures PATENTED JAN29 I974 INVENTORS HOWARD DONPWITZ O,E' WILLIAM J. OHARA ATTORNEY SURGICAL IMPLANT DEVICE This invention relates generally to surgical devices and more particularly to a surgical device to be implanted in an eye for controlling intra-occular pressure, as, for example, in a glaucoma diseased eye wherein there is an increased pressure built up within the eye from the accumulation of fluid.
Normally, fluid called aqueous humor, which constantly forms and enters portions of the eye globe known as the anterior and posterior chambers, are balanced by those fluids which leave the eye by drainage through the canal of Schlemm. In glaucoma, for example, more fluid is secreted than is discharged, which results in an increase in intra-occular pressure, causing pain, interference with vision, and eventual blindness. In acute and chronic cases of glaucoma, this fluid imbalance is usually due to a blockage of the canal of Schlemm from a change in the character of the filtering or drainage tissues or a collapse of the angle of the anterior chamber.
Many surgical procedures for treating acute and chronic glaucoma and involving incisions and device implants have been proposed or tried, all of which has met with rather varied and inconsistent results. One such device includes, for example, an elongated tubular section curved to the same radius as an eye and an attached right angled section including a bore and adapted for insertion into a hole surgically drilled in an eye so as to provide for the drainage of fluid through the device into the retrobulbar space behind the eye.
Particular problems and disadvantages apparent in this and other prior art devices are the general lack of any provisions in the devices to safeguard against excessive drainage of fluid which could bring about a collapse of the anterior chamber causing a possible loss of sight or the eye itself. The drilling of a hole, for example, for receiving the right angled section for the abovedescribed device may in itself cause an excessive loss of fluid. Also, devices of the type including an extended bore or continuous open channel for fluid drainage also provide a means for the outside entry of harmful bacteria into the anterior chamber, with a possible resulting infection of the eye.
It is an object of the present invention to provide an implant device which is simple in construction, free of the aforementioned disadvantages and effective in controlling excessive intra-occular pressure.
It is another object of the present invention to provide a device which when surgically implanted in a glaucomatic eye operates in a manner to relieve an excessive intra-occular pressure.
It is another object of the present invention to provide a device which when implanted in a glaucoma diseased eye serves as a drain for excess fluid built up in the anterior and posterior chambers.
Briefly described, the implant device of the present invention includes an elongated shank member have a passageway axially extending therethrough and mounting a valve therein to normally provide for closure of the passageway, the valve opening in response to a predetermined pressure differential within the passageway. A flange is provided on one end of the shank member to anchor the implant device. Means are also provided on the shank member for insuring retention of the device in the eye.
The novel features which are considered to be characteristic of the invention are set forth with particularity in the appended claims. The invention itself, however, both as to its organization and method of operation as well as additional objects and advantages thereof, will best be understood from the following description when read in connection with the accompanying drawing in which:
FIG. 1 is a vertical section of a human eye showing the device of the present invention implanted therein;
FIG. 2 is a perspective view of the implant device of the invention;
FIG. 3 is a top view of the device of FIG. 2;
FIG. 4 is an enlarged front sectional view taken along the lines 4-4 of FIG. 3;
FIG. 5 is an enlarged section of the valve area shown in FIG. 4; and
FIG. 6 is a modified front sectional view of the flange and upper shank portion of the device.
Referring now to the drawing, and to FIG. 1 thereof, there is illustrated a human eyeball which includes the lens 10, posterior chamber 12, anterior chamber 14, iris 16, sclera 18, canal of Schlemm 20, cornea 22, and the conjunctiva 24 of the eye. As shown in the Figure, the device 26 of the present invention when implanted in the eye preferably extends through the cornea 22 and into the anterior chamber 14 of the eye.
With reference particularly now to FIGS. 2, 3, 4 and 5 in the drawing, a preferred embodiment of an implant device in accordance with the present invention comprises an elongated body or shank portion 28 generally cylindrical in shape, slightly tapered, and having a bore or passageway 30 extending axially therethrough. One end 32 of the shank portion 28 is capped by an integrally formed circular flange 34 with the passageway opening therethrough. The other end of the passageway opens through the bottom portion 36 of the shank 28 which has an obliquely slanted end face 38 to facilitate implantation of the device 26 into an eye as will hereinafter be described.
As shown particularly in FIG. 4, the flange portion 34 is preferably slanted or obliquely positioned relative to the longitudinal axis of the shank portion and has its top and bottom surfaces 40 and 42 arcuately contoured so as to conform generally to the cornea or other portion of the eyeball surface into which the device is to be implanted. The flange portion 34 being seated thereon thus serves to prevent the implant device from being submerged into the eye after insertion.
In spaced array along the periphery of the flange portion 34 are a plurality of apertures 44. Spaced downwardly from the flange portion 34 and extending up and outwardly from the outside surface of the shank portion 28 are a pair of integrally formed projections or barbs 46 which may serve as a means for retaining the device in the eye after implantation. It is important that the barbs 46 be spaced sufficiently beneath the underside of the flange so as to accommodate therebetween the wall thickness of the cornea or other portion of the eyeball receiving the implant device, or alternately be spaced so as to lock within the stroma or mid point of the cornea.
In accordance with the invention, a valve means 48 is provided and seated within the shank passageway 30 so as to normally provide for a closure of the passageway, and for opening in response to a predetermined pressure differential within the passageway and on opposing portions of the valve means.
More particularly, and as shown in FIG. 5, a preferred valve means includes a pair of opposing flexible web or reed- like members 50 and 52 formed integral with and extending out from the inside wall surfaces bounding the passageway 30 and normally abutting one another so as to close off the passageway and inhibit any flow therethrough. Preferably the valve is formed in the shank portion at a point intermediate the ends thereof. The abutting engagement of the reed members 50 and 52 is such that the valve functions in a one-way manner by allowing for the upward deflection of the reed members 50 and 52 in response to the presence of a predetermined increase in pressure exerted on the bottom surfaces 54 and 56 (as viewed in the Figures) of the reed members relative to the pressure exerted on the top surfaces 58 and 60 of the reed members.
It will be appreciated that in fabricating the: device of the invention, the material chosen must be inert and nontoxic. Also it is desirable that the material be somewhat resilient so as to allow for an integral formation within the internal passageway of a one-way valve. One material that has proved satisfactory for this purpose is manufactured by the DuPont Company, under the trade name Teflon. The double reed valve may be fabricated, for example, by machining the shank portion bore from both ends to provide a diaphragm like membrane between the bored end portions. The membrane is then pierced to create a double reed type valve. Piercing of the membrane is from the bottom end of the bore such that the reed valve operates to open only toward the top or flange end of the shank, thereby functioning as a one-way type valve. The valve is thus dependent on the memory retention or resiliency of the material of which it is formed, in addition to the back pressure exerted on the flange side of the valve, to return to its seat or closed position.
It should be noted that the pressure differential or program setting to which the valve openly responds is determined by the thickness of the membrane forming the reed members, the general characteristics and resiliency of the material used in fabricating the device as well as the size of the bore opening or passageway.
Advantages in the use of a double reed type valve are the relative ease with which the response threshold point of the valve can be controlled, i.e., the point at which the valve responds to a pressure difference. Also the greater the pressure difference, the more the valve flaps or reed members will deflect to open the passageway and allow for fluid discharge, the valve opening being directly proportional to the applied pressure differential.
It will be also be apparent that other types of valve means, as, for example, a ball valve, single reed valve or a spring valve may be used in the construction of the device of the present invention.
Insertion and operation of the implant device into an eye will now be described.
As shown in FIG. 1, the device of the present invention may be implanted into and through the cornea 22 and into communication with the anterior chamber 14, the implantation preferably being made in the upper portion of the cornea just beneath the canal of Schlemm 20.
As was heretofore noted, the shank portion of the implant device is preferably provided with a tapered outside contour as shown in the Figures so as to facilitate easy insertion, either directly or through a prepared tract into the eye. When insertion of the implant device is to be in the cornea, for example, a hyperdermic needle-like instrument is preferably used to first pierce the cornea to provide a tract for receiving the device. The cornea is a desirable area of the eye for receiving the device since the inherent pliable nature of the cornea will permit the easy implantation of the device and also enhance a sealing around the shank portion of the device after it is received in the eye. Also, in piercing the cornea to provide the receiving tract for the implant device, there is substantially no tissue or fluid loss.
It will be understood that the device can be inserted directly into the cornea without the aid of a tract. Also, other areas of the eyeball may be used for implantation of the device of the present invention.
Upon implantation, the device flange portion 34 will seat on the cornea or other area of the eye receiving the device, while the barb projections 46 lock against the underside of the receiving tissue for retaining the device in the eye. Altemately, the barb projections may be spaced so as to lock within the stroma of the cornea, or mid area of the receiving tissue.
As was heretofore noted, the flange portion 34 of the implant device may be provided with a plurality of apertures 44 spaced around the periphery thereof. These flange apertures 44 may serve two functions. When the device is implanted in the cornea portion of the eye, the apertures allow the eye tears to wash and provide for the normal irrigation of the cornea area under the flange. Where the implant is in another area of the eye, as, for example, through the sclera, the flange apertures may be used to anchor the device in the eye with the aid of sutures.
Initially the pressure of the top surfaces 58 and 60 of the valve, i.e., the discharge end of the valve, which is exposed to the outside of the eye after implantation of the device, is at or about the atmospheric pressure. Normally, the pressure inside the eye globe, and more particularly in the anterior and posterior chambers thereof is understood to be between 15 and 25 millimeters (mm.) of mercury above the atmospheric pressure. With the occurrence of an abnormal intra-occular build up of pressure inside the eye and again particularly in the anterior chamber which after insertion of the device is effectively in communication with the bottom surfaces 54 and 56 of the reed members, i.e., the intake end of the valve, a point is reached, i.e., the threshold or program setting of the valve, wherein the valve will open to allow the passage of fluid from the anterior chamber through the shank bore of passageway to the outside of the eye wherein it mingles with existing eye tears and is disposed of in the normal manner. The increased intra-occular pressure built up is in this way controlled. The pressure point at which the valve may be programmed to open may, for example, be between 20 and 25 mm. of mercury.
When the pressure difference on both sides of the valve membrane, i.e., the top and bottom surfaces of the reed members, decreases to a preset level substantially equal to the aforementioned program setting, the valve closes. The rate and degree of valve opening is a function of the amount of the intra-occular pressure and consequently the pressures exerted on the bottom surfaces of the valve reed members. The valve serves to regulate the flow of fluid through the shank passageway in direct proportion to the degree of excessive intra-occular pressure built up in the eye. Since the intraoccular pressure will be changing as the valve allows for the discharge of fluid, the valve reeds will tend to substantially open and close or flutter in operation.
Since the cornea does not have blood vessels or a blood supply, by this fluttering action of the valve, the circulation of the aqueous is enhanced against the posterior part of the cornea. This is desirable since the aqueous normally provides a means of carrying nourishment to the cornea and also for the disposal of waste matter.
It should be noted that another advantage inherent in the implant device of the present invention is its minute size. A device in accordance with the invention has been constructed with an operating valve as abovedescribed and with a shank length of approxiamtely 2.5 mm., a bore diameter of approximately 0.5 mm., and a flange portion 2 mm. in diameter.
It will be appreciated that the relatively small size of the device will minimize friction between an eyelid and the device when implanted. Also, during implantation of the device and because of its size, there will be substantially no tissue of fluid loss.
Turning now to FIG. 6, there is illustrated a fragmentary sectional view showing a modified embodiment of the flange and retaining means portons of the implant device of the present invention.
More particularly, the upper end of the shank portion 28 is necked down as shown so as to provide a step or shelf 62 which functions to help retain the implant device in an eye in a manner similar to that of the heretofore described barb projections shown in FIG. 4. The top surface 40 of the flange portion 34 is provided with an integrally formed annular rib or ridge member 64. With the device implanted in an area of the eye other than the cornea, and more particularly the sclera, the ridge 64 will serve to discourage the formation of cicatrix or scar tissue over the flange opening of the passageway.
It will thus be seen that the device herein described may be easily implanted in a human eye, provides a minimum of discomfort to the recipient, and functions in a simple, eyt effective manner to control an intraoccular pressure build up. It will also be clear that variations in the details of consruction which are specifically illustrated and described may be resorted to without departing from the scope of the invention.
What is claimed is:
1. A surgical implant device for implantation in an eye comprising:
an elongated shank member generally tubular in shape and having a flange surrounding one end thereof, said shank member being provided with a passageway opening in said one end through said flange and axially extending through said shank and out the other end thereof;
valve means seated within said passageway and normally positioned to provide for closure thereof, said valve means opening in response to a predetermined pressure differential within said passageway and on opposing sides of the valve; and
means integrally formed on and disposed along said shank member axially spaced from said flange for the retention of said device in an eye; said flange being in an inclined position relative to the axis of said shank member and the side of said flange from which the shank extends being arcuately contoured to conform generally to the surface of a human eye. 2. A device as defined in claim 1 wherein said retention means includes a plurality of spaced projections formed on the outside surface of said shank member and angled upwardly toward said flange portion.
3. A device as defined in claim 1 wherein a first portion of said shank member depends from said flange portion and is necked down to form a step with the remaining portion thereof, the remaining portion of said shank member thereafter tapering toward said botton end.
4. A device as defined in claim 1 wherein said flange includes a ridge member integrally formed on the surface thereof opposite said shank and concentric with the opening therein,
5. A device as defined in claim 1 wherein said valve means includes a pair of opposing reed members integrally formed within said passageway and extending thereacross so as to normally close off said passageway. 6. A device as defined in claim 5 wherein said flange includes a plurality of openings spaced around the periphery thereof.
7. A surgical device for implantation in an eye comprising:
a flange portion having top and bottom surfaces and a central aperture therein;
an elongated body portion integral with said flange portion and depending from the bottom surface thereof, said body portion having an internal passageway continuous with said flange opening and extending lengthwise through said body portion to an axially in-line opening at the other end thereof;
pressure sensitive valve means seated within said passageway and normally positioned to provide for closure of said passageway, said valve means opening in response to a predetermined pressure differential within said passageway and on opposing sides of the valve;
said flange portion being generally circular in shape and overlying said body portion in an inclined position relative to the longitudinal axis of said body portion, said flange including a plurality of apertures spaced along the periphery thereof; and means integrally formed on and displaced along said body portion beneath said flange portion for the retention of said device in an eye, said retention means including a plurality of spaced projections formed along the outside surface of said body portion and angled upwardly toward said flange portion.

Claims (7)

1. A surgical implant device for implantation in an eye comprising: an elongated shank member generally tubular in shape and having a flange surrounding one end thereof, said shank member being provided with a passageway opening in said one end through said flange and axially extending through said shank and out the other end thereof; valve means seated within said passageway and normally positioned to provide for closure thereof, said valve means opening in response to a predetermined pressure differential within said passageway and on opposing sides of the valve; and means integrally formed on and disposed along said shank member axially spaced from said flange for the retention of said device in an eye; said flange being in an inclined position relative to the axis of said shank member and the side of said flange from which the shank extends being arcuately contoured to conform generally to the surface of a human eye.
2. A device as defined in claim 1 wherein said retention means includes a plurality of spaced projections formed on the outside surface of said shank member and angled upwardly toward said flange portion.
3. A device as defined in claim 1 wherein a first portion of said shank member depends from said flange portion and is necked down to form a step with the remaining portion thereof, the remaining portion of said shank member thereafter tapering toward said botton end.
4. A device as defined in claim 1 wherein said flange includes a ridge member integrally formed on the surface thereof opposite said shank and concentric with the opening therein,
5. A device as defined in claim 1 wherein said valve means includes a pair of opposing reed members integrally formed within said passageway and extending thereacross so as to normally close off said passageway.
6. A device as defined in claim 5 wherein said flange includes a plurality of openings spaced around the periphery thereof.
7. A surgical device for implantation in an eye comprising: a flange portion having top and bottom surfaces and a central aperture therein; an elongated body portion integral with said flange portion and depending from the bottom surface thereof, said body portion having an internal passageway continuous with said flange opening and extending lengthwise through said body portion to an axially in-line opening at the other end thereof; pressure sensitive valve means seated within said passageway aNd normally positioned to provide for closure of said passageway, said valve means opening in response to a predetermined pressure differential within said passageway and on opposing sides of the valve; said flange portion being generally circular in shape and overlying said body portion in an inclined position relative to the longitudinal axis of said body portion, said flange including a plurality of apertures spaced along the periphery thereof; and means integrally formed on and displaced along said body portion beneath said flange portion for the retention of said device in an eye, said retention means including a plurality of spaced projections formed along the outside surface of said body portion and angled upwardly toward said flange portion.
US00129384A 1971-03-30 1971-03-30 Surgical implant device Expired - Lifetime US3788327A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12938471A 1971-03-30 1971-03-30

Publications (1)

Publication Number Publication Date
US3788327A true US3788327A (en) 1974-01-29

Family

ID=22439695

Family Applications (1)

Application Number Title Priority Date Filing Date
US00129384A Expired - Lifetime US3788327A (en) 1971-03-30 1971-03-30 Surgical implant device

Country Status (1)

Country Link
US (1) US3788327A (en)

Cited By (273)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3890976A (en) * 1972-10-26 1975-06-24 Medical Products Corp Catheter tip assembly
US3915172A (en) * 1970-05-27 1975-10-28 Ceskoslovenska Akademie Ved Capillary drain for glaucoma
US3938529A (en) * 1974-07-22 1976-02-17 Gibbons Robert P Indwelling ureteral catheter
US4037604A (en) * 1976-01-05 1977-07-26 Newkirk John B Artifical biological drainage device
US4175563A (en) * 1977-10-05 1979-11-27 Arenberg Irving K Biological drainage shunt
US4402681A (en) * 1980-08-23 1983-09-06 Haas Joseph S Artificial implant valve for the regulation of intraocular pressure
EP0102747A1 (en) * 1982-07-28 1984-03-14 Thomas C. White Ocular pressure relief device
US4474569A (en) * 1982-06-28 1984-10-02 Denver Surgical Developments, Inc. Antenatal shunt
US4521210A (en) * 1982-12-27 1985-06-04 Wong Vernon G Eye implant for relieving glaucoma, and device and method for use therewith
FR2562419A1 (en) * 1984-04-06 1985-10-11 Binder Perry HYDROGEL SETON AND METHOD FOR REDUCING INTRAOCULAR PRESSURE
US4587954A (en) * 1983-12-29 1986-05-13 Habley Medical Technology Corporation Elastomeric prosthetic sphincter
US4604087A (en) * 1985-02-26 1986-08-05 Joseph Neil H Aqueous humor drainage device
US4645493A (en) * 1983-01-07 1987-02-24 N.U.S. S.R.L. Catheter for medical-surgical application
EP0228185A1 (en) * 1985-11-27 1987-07-08 Thomas C. White Tissue-implantable fluid-dissipating device
US4722724A (en) * 1986-06-23 1988-02-02 Stanley Schocket Anterior chamber tube shunt to an encircling band, and related surgical procedure
US4781675A (en) * 1985-11-27 1988-11-01 White Thomas C Infusion cannula
WO1989000869A1 (en) * 1987-08-06 1989-02-09 White Thomas C Glaucoma drainage in the lacrimal system
US4808183A (en) * 1980-06-03 1989-02-28 University Of Iowa Research Foundation Voice button prosthesis and method for installing same
US4813941A (en) * 1987-09-03 1989-03-21 Leslie Shea Pneumothorax treatment device
US4826478A (en) * 1986-06-23 1989-05-02 Stanley Schocket Anterior chamber tube shunt to an encircling band, and related surgical procedure
US4886488A (en) * 1987-08-06 1989-12-12 White Thomas C Glaucoma drainage the lacrimal system and method
US4936825A (en) * 1988-04-11 1990-06-26 Ungerleider Bruce A Method for reducing intraocular pressure caused by glaucoma
US4968296A (en) * 1989-12-20 1990-11-06 Robert Ritch Transscleral drainage implant device for the treatment of glaucoma
US5064417A (en) * 1988-10-11 1991-11-12 Co Pharma Corporation S.R.L. Device for fastening a catheter to a cranial theca for performing cerebro spinal fluid drainage to the outside operations
US5092837A (en) * 1989-12-20 1992-03-03 Robert Ritch Method for the treatment of glaucoma
US5098393A (en) * 1988-05-31 1992-03-24 Kurt Amplatz Medical introducer and valve assembly
US5171213A (en) * 1991-08-14 1992-12-15 Price Jr Francis W Technique for fistulization of the eye and an eye filtration prosthesis useful therefor
US5178604A (en) * 1990-05-31 1993-01-12 Iovision, Inc. Glaucoma implant
US5207660A (en) * 1991-04-26 1993-05-04 Cornell Research Foundation, Inc. Method for the delivery of compositions to the ocular tissues
US5221278A (en) * 1992-03-12 1993-06-22 Alza Corporation Osmotically driven delivery device with expandable orifice for pulsatile delivery effect
US5397300A (en) * 1990-05-31 1995-03-14 Iovision, Inc. Glaucoma implant
US5476445A (en) * 1990-05-31 1995-12-19 Iovision, Inc. Glaucoma implant with a temporary flow restricting seal
WO1996018357A2 (en) * 1994-12-09 1996-06-20 Bays F Barry Valve assembly and method for relieving synovial fluid pressure
GB2296663A (en) * 1995-01-03 1996-07-10 Ahmed Salih Mahmud Drainage device for alleviating excess ophthalmic fluid pressure
US5626559A (en) * 1994-05-02 1997-05-06 Ramot University Authority For Applied Research And Industrial Development Ltd. Ophthalmic device for draining excess intraocular fluid
US5626558A (en) * 1995-05-05 1997-05-06 Suson; John Adjustable flow rate glaucoma shunt and method of using same
US5660205A (en) * 1994-12-15 1997-08-26 Epstein; Alan B. One-way valve
US5702414A (en) * 1995-05-14 1997-12-30 Optonol Ltd Method of implanting an intraocular implant
WO1999008741A1 (en) * 1997-08-19 1999-02-25 Abbeymoor Medical, Inc. Urethral device with anchoring system
US5968058A (en) * 1996-03-27 1999-10-19 Optonol Ltd. Device for and method of implanting an intraocular implant
US6004302A (en) * 1997-08-28 1999-12-21 Brierley; Lawrence A. Cannula
EP0967946A1 (en) * 1996-11-29 2000-01-05 The Lions Eye Institute of Western Australia Incorporated Biological microfistula tube and implantation method and apparatus
US6050970A (en) * 1997-05-08 2000-04-18 Pharmacia & Upjohn Company Method and apparatus for inserting a glaucoma implant in an anterior and posterior segment of the eye
WO2000064393A1 (en) * 1999-04-26 2000-11-02 Lynch Mary G Shunt device and method for treating glaucoma
US6203513B1 (en) 1997-11-20 2001-03-20 Optonol Ltd. Flow regulating implant, method of manufacture, and delivery device
US6258060B1 (en) 1997-02-07 2001-07-10 Abbeymoon Medical, Inc. Urethral apparatus with position indicator and methods of use thereof
US6293951B1 (en) * 1999-08-24 2001-09-25 Spiration, Inc. Lung reduction device, system, and method
US20020095209A1 (en) * 1997-09-16 2002-07-18 Gholam-Reza Zadno-Azizi Body fluid flow control device
US20020112729A1 (en) * 2001-02-21 2002-08-22 Spiration, Inc. Intra-bronchial obstructing device that controls biological interaction with the patient
WO2002070045A1 (en) * 2001-01-09 2002-09-12 Brown J David Glaucoma treatment device and method
US20020143284A1 (en) * 2001-04-03 2002-10-03 Hosheng Tu Drug-releasing trabecular implant for glaucoma treatment
US20020169130A1 (en) * 2001-05-03 2002-11-14 Hosheng Tu Medical device and methods of use for glaucoma treatment
US20020188308A1 (en) * 2001-04-07 2002-12-12 Hosheng Tu Glaucoma stent and methods thereof for glaucoma treatment
US20030050648A1 (en) * 2001-09-11 2003-03-13 Spiration, Inc. Removable lung reduction devices, systems, and methods
US20030055372A1 (en) * 1999-04-26 2003-03-20 Lynch Mary G. Shunt device and method for treating glaucoma
US20030070682A1 (en) * 2001-10-11 2003-04-17 Wilson Peter M. Bronchial flow control devices and methods of use
US6558342B1 (en) 1999-06-02 2003-05-06 Optonol Ltd. Flow control device, introducer and method of implanting
US20030088260A1 (en) * 2001-11-08 2003-05-08 Smedley Gregory T. Combined treatment for cataract and glaucoma treatment
US20030097151A1 (en) * 2001-10-25 2003-05-22 Smedley Gregory T. Apparatus and mitochondrial treatment for glaucoma
JP2003520077A (en) * 2000-01-12 2003-07-02 ベクトン・ディキンソン・アンド・カンパニー Systems and methods for reducing intraocular pressure
US20030135149A1 (en) * 2002-01-13 2003-07-17 Cheryl Cullen Sinus valved glaucoma shunt
US20030158515A1 (en) * 2002-02-21 2003-08-21 Spiration, Inc. Device and method for intra-bronchial provision of a therapeutic agent
US20030181848A1 (en) * 2000-04-14 2003-09-25 Bergheim Olav B. Implant with drug coating
US20030181922A1 (en) * 2002-03-20 2003-09-25 Spiration, Inc. Removable anchored lung volume reduction devices and methods
US20030183235A1 (en) * 2001-10-25 2003-10-02 Spiration, Inc. Bronchial obstruction device deployment system and method
US20030195385A1 (en) * 2002-04-16 2003-10-16 Spiration, Inc. Removable anchored lung volume reduction devices and methods
US20030192551A1 (en) * 2000-03-04 2003-10-16 Deem Mark E. Methods and devices for use in performing pulmonary procedures
US20030212412A1 (en) * 2002-05-09 2003-11-13 Spiration, Inc. Intra-bronchial obstructing device that permits mucus transport
US20030216769A1 (en) * 2002-05-17 2003-11-20 Dillard David H. Removable anchored lung volume reduction devices and methods
EP1184010A3 (en) * 2000-08-29 2003-12-03 Aixmed Gesellschaft für Medizintechnik mbH Aqueous humour drainage device
US20030228344A1 (en) * 2002-03-08 2003-12-11 Fields Antony J. Methods and devices for inducing collapse in lung regions fed by collateral pathways
US6666841B2 (en) 2001-05-02 2003-12-23 Glaukos Corporation Bifurcatable trabecular shunt for glaucoma treatment
US20040010209A1 (en) * 2002-07-15 2004-01-15 Spiration, Inc. Device and method for measuring the diameter of an air passageway
US20040024345A1 (en) * 2002-04-19 2004-02-05 Morteza Gharib Glaucoma implant with valveless flow bias
US6692455B2 (en) 1995-04-26 2004-02-17 Medtronic Xomed, Inc. Composite ventilation tube
US20040039250A1 (en) * 2002-05-28 2004-02-26 David Tholfsen Guidewire delivery of implantable bronchial isolation devices in accordance with lung treatment
US20040050392A1 (en) * 2001-08-28 2004-03-18 Hosheng Tu Glaucoma stent for treating glaucoma and methods of use
US20040055606A1 (en) * 2001-03-02 2004-03-25 Emphasys Medical, Inc. Bronchial flow control devices with membrane seal
US20040059263A1 (en) * 2002-09-24 2004-03-25 Spiration, Inc. Device and method for measuring the diameter of an air passageway
US20040060563A1 (en) * 2001-03-02 2004-04-01 Alan Rapacki Bronchial flow control devices and methods of use
US20040073156A1 (en) * 2001-01-09 2004-04-15 Brown J. David Glaucoma treatment device and method
US20040074491A1 (en) * 2001-03-02 2004-04-22 Michael Hendricksen Delivery methods and devices for implantable bronchial isolation devices
US6730056B1 (en) * 2000-09-21 2004-05-04 Motorola, Inc. Eye implant for treating glaucoma and method for manufacturing same
US20040102729A1 (en) * 2002-04-08 2004-05-27 David Haffner Devices and methods for glaucoma treatment
US20040111050A1 (en) * 2000-04-14 2004-06-10 Gregory Smedley Implantable ocular pump to reduce intraocular pressure
US20040127843A1 (en) * 2000-04-14 2004-07-01 Hosheng Tu Glaucoma implant with therapeutic agents
US20040147870A1 (en) * 2002-04-08 2004-07-29 Burns Thomas W. Glaucoma treatment kit
WO2004062469A2 (en) * 2003-01-13 2004-07-29 Clarity Corporation Sinus valved glaucoma shunt
US20040148035A1 (en) * 2002-11-27 2004-07-29 Michael Barrett Delivery methods and devices for implantable bronchial isolation devices
US20040200484A1 (en) * 2003-04-08 2004-10-14 Springmeyer Steven C. Bronchoscopic lung volume reduction method
US20040210248A1 (en) * 2003-03-12 2004-10-21 Spiration, Inc. Apparatus, method and assembly for delivery of intra-bronchial devices
EP1473004A2 (en) 1995-05-14 2004-11-03 Optonol Ltd. Ophtalmic implant for treating glaucoma and delivery device
US20040243393A1 (en) * 2003-05-29 2004-12-02 Microsoft Corporation Semantic object synchronous understanding implemented with speech application language tags
US20040254517A1 (en) * 2003-02-18 2004-12-16 Hugo Quiroz-Mercado Methods and devices for draining fluids and lowering intraocular pressure
US20050027261A1 (en) * 2003-07-30 2005-02-03 Karla Weaver Pressure actuated valve with improved slit configuration
US20050049578A1 (en) * 2000-04-14 2005-03-03 Hosheng Tu Implantable ocular pump to reduce intraocular pressure
US20050051163A1 (en) * 2000-03-04 2005-03-10 Deem Mark E. Methods and devices for use in performing pulmonary procedures
US20050107734A1 (en) * 2003-11-14 2005-05-19 Coroneo Minas T. Ocular pressure regulation
US20050119636A1 (en) * 2001-05-02 2005-06-02 David Haffner Implant with intraocular pressure sensor for glaucoma treatment
US20050119737A1 (en) * 2000-01-12 2005-06-02 Bene Eric A. Ocular implant and methods for making and using same
US20050125071A1 (en) * 2002-03-11 2005-06-09 Oded Nahleili Polymeric stent useful for the treatment of the salivary gland ducts and method for using the same
US20050137714A1 (en) * 2003-08-08 2005-06-23 Gonzalez Hugo X. Bronchoscopic repair of air leaks in a lung
US20050171490A1 (en) * 2004-01-29 2005-08-04 Karla Weaver Stacked membrane for pressure actuated valve
US20050171489A1 (en) * 2004-01-29 2005-08-04 Karla Weaver Pressure activated safety valve with anti-adherent coating
US20050171510A1 (en) * 2004-01-29 2005-08-04 Dicarlo Paul Pressure actuated safety valve with spiral flow membrane
US20050178389A1 (en) * 2004-01-27 2005-08-18 Shaw David P. Disease indications for selective endobronchial lung region isolation
US20050184004A1 (en) * 2004-02-24 2005-08-25 Rodgers M. S. Glaucoma implant having MEMS filter module
US20050184003A1 (en) * 2004-02-24 2005-08-25 Rodgers M. S. MEMS filter module
US20050192527A1 (en) * 2001-05-02 2005-09-01 Morteza Gharib Glaucoma implant with extending members
US20050197613A1 (en) * 2004-03-02 2005-09-08 Sniegowski Jeffry J. Implant having MEMS flow module with movable, flow-controlling baffle
US20050197653A1 (en) * 2004-03-02 2005-09-08 Sniegowski Jeffry J. Filter assembly with microfabricated filter element
US20050196344A1 (en) * 2004-02-27 2005-09-08 Mccutcheon John Methods and devices for blocking flow through collateral pathways in the lung
US20050250788A1 (en) * 2004-01-30 2005-11-10 Hosheng Tu Aqueous outflow enhancement with vasodilated aqueous cavity
US20050266047A1 (en) * 2002-04-08 2005-12-01 Hosheng Tu Injectable glaucoma implants with multiple openings
US20050271704A1 (en) * 2002-04-08 2005-12-08 Hosheng Tu Injectable glaucoma implants with multiple openings
US20050273033A1 (en) * 2002-05-29 2005-12-08 Grahn Bruce H Shunt and method treatment of glaucoma
US20050277864A1 (en) * 2000-04-14 2005-12-15 David Haffner Injectable gel implant for glaucoma treatment
US20050283108A1 (en) * 2004-06-10 2005-12-22 Savage James A Apparatus and method for non-pharmacological treatment of glaucoma and lowering intraocular pressure
US20050288617A1 (en) * 2004-06-25 2005-12-29 Ira Yaron Flow regulating implants
US20060004305A1 (en) * 2002-11-27 2006-01-05 George Robert M Delivery methods and devices for implantable bronchial isolation devices
US20060020347A1 (en) * 2004-03-08 2006-01-26 Michael Barrett Implanted bronchial isolation devices and methods
US20060030863A1 (en) * 2004-07-21 2006-02-09 Fields Antony J Implanted bronchial isolation device delivery devices and methods
US20060036207A1 (en) * 2004-02-24 2006-02-16 Koonmen James P System and method for treating glaucoma
US20060107956A1 (en) * 2004-11-19 2006-05-25 Hendricksen Michael J Bronchial flow control devices and methods of use
US20060173399A1 (en) * 2005-02-01 2006-08-03 Rodgers M S MEMS flow module with pivoting-type baffle
US20060184139A1 (en) * 2005-02-11 2006-08-17 Quigley Karla W Pressure activated safety valve with improved flow characteristics and durability
US20060206147A1 (en) * 2002-02-21 2006-09-14 Devore Lauri J Intra-bronchial obstruction device that provides a medicant intra-bronchially to the patient
US20060206049A1 (en) * 2005-03-14 2006-09-14 Rodgers M S MEMS flow module with piston-type pressure regulating structure
US20060219627A1 (en) * 2005-03-31 2006-10-05 Rodgers M S MEMS filter module with concentric filtering walls
US20060235432A1 (en) * 2002-02-21 2006-10-19 Devore Lauri J Intra-bronchial obstructing device that controls biological interaction with the patient
US20070005083A1 (en) * 1997-04-30 2007-01-04 Sabaratham Sabanathan Occlusion device
US20070004998A1 (en) * 2005-06-21 2007-01-04 Rodgers M S Glaucoma implant having MEMS flow module with flexing diaphragm for pressure regulation
US7186232B1 (en) 2002-03-07 2007-03-06 Glaukoa Corporation Fluid infusion methods for glaucoma treatment
US20070106200A1 (en) * 2005-11-08 2007-05-10 Brian Levy Intraocular shunt device and method
US20070149915A1 (en) * 2003-05-05 2007-06-28 Judith Yablonski Internal shunt and method for treating glaucoma
US20070156079A1 (en) * 2005-09-16 2007-07-05 Bg Implant, Inc. Glaucoma Treatment Devices and Methods
US20070173777A1 (en) * 2006-01-25 2007-07-26 Nathan Murphy Valved catheter with power injection bypass
US20070191863A1 (en) * 2006-01-17 2007-08-16 De Juan Eugene Jr Glaucoma Treatment Device
US20070233037A1 (en) * 2006-01-17 2007-10-04 Gifford Hanson S Iii Drug Delivery Treatment Device
US20070235846A1 (en) * 2006-04-01 2007-10-11 Stats Chippac Ltd. Integrated circuit package system with net spacer
US20070293807A1 (en) * 2006-05-01 2007-12-20 Lynch Mary G Dual drainage pathway shunt device and method for treating glaucoma
US20080072914A1 (en) * 2006-08-25 2008-03-27 Hendricksen Michael J Bronchial Isolation Devices for Placement in Short Lumens
US20080108933A1 (en) * 2006-06-30 2008-05-08 Dao-Yi Yu Methods, Systems and Apparatus for Relieving Pressure in an Organ
US20080172204A1 (en) * 2007-01-15 2008-07-17 Fujitsu Limited Step counter and method of counting steps
US20080195044A1 (en) * 2005-03-23 2008-08-14 Akira Nishimura Ophthalmic Cannula
US20080228127A1 (en) * 2006-11-10 2008-09-18 Glaukos Corporation Uveoscleral shunt and methods for implanting same
US20080277332A1 (en) * 2007-05-11 2008-11-13 Becton, Dickinson And Company Micromachined membrane filter device for a glaucoma implant and method for making the same
US7488303B1 (en) 2002-09-21 2009-02-10 Glaukos Corporation Ocular implant with anchor and multiple openings
US20090082860A1 (en) * 2007-09-24 2009-03-26 Schieber Andrew T Ocular Implants with Asymmetric Flexibility
US20090099530A1 (en) * 2007-10-12 2009-04-16 Martin Neal Adams Valve loader method, system, and apparatus
US20090132040A1 (en) * 2007-11-20 2009-05-21 Ivantis, Inc. Ocular Implant Delivery System and Method
US20090204053A1 (en) * 2008-02-11 2009-08-13 Optonol Ltd. Devices and methods for opening fluid passageways
US20090227933A1 (en) * 2003-02-18 2009-09-10 S.K. Pharmaceuticals Optic nerve implants
US20090227934A1 (en) * 2008-03-05 2009-09-10 Euteneuer Charles L Methods and Apparatus for Treating Glaucoma
US20090292252A1 (en) * 2008-05-21 2009-11-26 Raymond Lareau Pressure Activated Valve for High Flow Rate and Pressure Venous Access Applications
US20090292262A1 (en) * 2007-10-12 2009-11-26 Martin Neal Adams Valve loader method, system, and apparatus
US20100114006A1 (en) * 2008-11-05 2010-05-06 Advanced Medical Optics, Inc. Glaucoma drainage shunts and methods of use
US20100137981A1 (en) * 2008-06-25 2010-06-03 Silvestrini Thomas A Ocular implant with shape change capabilities
US20100174272A1 (en) * 2009-01-02 2010-07-08 Weiner Alan L In-situ refillable ophthalmic implant
US20100191192A1 (en) * 2009-01-28 2010-07-29 Jayanthi Prasad Three-way Valve for Power Injection in Vascular Access Devices
US20100222733A1 (en) * 2007-09-24 2010-09-02 Schieber Andrew T Glaucoma Treatment Method
US20100249691A1 (en) * 2009-03-26 2010-09-30 Abbott Medical Optics Inc. Glaucoma shunts with flow management and improved surgical performance
US20100262071A1 (en) * 2006-03-31 2010-10-14 James Kutsko Articulable anchor
US20100274259A1 (en) * 1997-11-20 2010-10-28 Optonol Ltd. Fluid drainage device, delivery device, and associated methods of use and manufacture
US20100274258A1 (en) * 2009-01-28 2010-10-28 Silvestrini Thomas A Ocular implant with stiffness qualities, methods of implantation and system
AU2006202860B2 (en) * 2003-11-14 2010-11-04 Alcon Inc. Ocular pressure regulation
WO2010126076A1 (en) * 2009-04-30 2010-11-04 マニー株式会社 Cannula for ophthalmic surgery and method of manufacturing same
US20110009958A1 (en) * 2009-07-09 2011-01-13 John Wardle Ocular Implants and Methods for Delivering Ocular Implants Into the Eye
US20110009874A1 (en) * 2009-07-09 2011-01-13 John Wardle Single Operator Device for Delivering an Ocular Implant
US20110017207A1 (en) * 2001-03-02 2011-01-27 Pulmonx Corporation Bronchial flow control devices with membrane seal
US20110087093A1 (en) * 2009-10-09 2011-04-14 Navilyst Medical, Inc. Valve configurations for implantable medical devices
US20110098809A1 (en) * 2009-10-23 2011-04-28 John Wardle Ocular Implant System and Method
US20110105990A1 (en) * 2009-11-04 2011-05-05 Silvestrini Thomas A Zonal drug delivery device and method
US20110118612A1 (en) * 2009-11-18 2011-05-19 Navilyst Medical, Inc. Valved Catheter with Integrated Pressure Measurement Capabilities
US7951155B2 (en) 2002-03-15 2011-05-31 Glaukos Corporation Combined treatment for cataract and glaucoma treatment
US20110152775A1 (en) * 2009-12-23 2011-06-23 Jose Luis Lopez Ophthalmic valved trocar vent
US20110152774A1 (en) * 2009-12-23 2011-06-23 Jose Luis Lopez Ophthalmic valved trocar cannula
US20110226238A1 (en) * 2000-03-04 2011-09-22 Pulmonx Corporation Implanted bronchial isolation devices and methods
US20110238075A1 (en) * 2009-12-23 2011-09-29 Luke Clauson Drug delivery devices and methods
US20110282456A1 (en) * 2009-02-05 2011-11-17 Newvert Ltd. Implantable device for sealing a spinal annular fissure tear and method for deploying the same
US20120041270A1 (en) * 2007-06-29 2012-02-16 Applied Medical Technology, Inc. Molded and undivided medical penetrating device
US8246569B1 (en) * 2004-08-17 2012-08-21 California Institute Of Technology Implantable intraocular pressure drain
US8308701B2 (en) 2010-11-15 2012-11-13 Aquesys, Inc. Methods for deploying intraocular shunts
US8372026B2 (en) 2007-09-24 2013-02-12 Ivantis, Inc. Ocular implant architectures
US8377011B2 (en) 2004-01-29 2013-02-19 Angiodynamics, Inc. Pressure activated valve with high flow slit
US20130116652A1 (en) * 2010-07-12 2013-05-09 Ramot At Tel-Aviv University Ltd. Catheter cannula with anchoring elements, catheter including thereof, and/or catheterization method using
US8523821B2 (en) 2009-01-29 2013-09-03 Navilyst Medical, Inc Power injection valve
US8529523B2 (en) 2003-06-27 2013-09-10 Navilyst Medical, Inc. Pressure actuated valve with improved biasing member
US8540685B2 (en) 2003-08-29 2013-09-24 Navilyst Medical, Inc. Valved catheters including high flow rate catheters
US8551166B2 (en) 2007-11-20 2013-10-08 Ivantis, Inc. Methods and apparatus for delivering ocular implants into the eye
US8585629B2 (en) 2010-11-15 2013-11-19 Aquesys, Inc. Systems for deploying intraocular shunts
US8657776B2 (en) 2011-06-14 2014-02-25 Ivantis, Inc. Ocular implants for delivery into the eye
US8663150B2 (en) 2011-12-19 2014-03-04 Ivantis, Inc. Delivering ocular implants into the eye
US8663303B2 (en) 2010-11-15 2014-03-04 Aquesys, Inc. Methods for deploying an intraocular shunt from a deployment device and into an eye
US8672870B2 (en) 2007-07-17 2014-03-18 Transcend Medical, Inc. Ocular implant with hydrogel expansion capabilities
US8679074B2 (en) 2003-03-18 2014-03-25 Angiodynamics, Inc. Pressure responsive slit valve assembly for a plurality of fluids and uses thereof
US8721702B2 (en) 2010-11-15 2014-05-13 Aquesys, Inc. Intraocular shunt deployment devices
US8753320B2 (en) 2009-07-13 2014-06-17 Navilyst Medical, Inc. Method to secure an elastic component in a valve
US8758290B2 (en) 2010-11-15 2014-06-24 Aquesys, Inc. Devices and methods for implanting a shunt in the suprachoroidal space
US8765210B2 (en) 2011-12-08 2014-07-01 Aquesys, Inc. Systems and methods for making gelatin shunts
US8795241B2 (en) 2011-05-13 2014-08-05 Spiration, Inc. Deployment catheter
US8801766B2 (en) 2010-11-15 2014-08-12 Aquesys, Inc. Devices for deploying intraocular shunts
US8808222B2 (en) 2007-11-20 2014-08-19 Ivantis, Inc. Methods and apparatus for delivering ocular implants into the eye
US8828070B2 (en) 2010-11-15 2014-09-09 Aquesys, Inc. Devices for deploying intraocular shunts
US8852256B2 (en) 2010-11-15 2014-10-07 Aquesys, Inc. Methods for intraocular shunt placement
US8852136B2 (en) 2011-12-08 2014-10-07 Aquesys, Inc. Methods for placing a shunt into the intra-scleral space
US8852137B2 (en) 2010-11-15 2014-10-07 Aquesys, Inc. Methods for implanting a soft gel shunt in the suprachoroidal space
US8876791B2 (en) 2005-02-25 2014-11-04 Pulmonx Corporation Collateral pathway treatment using agent entrained by aspiration flow current
US8974511B2 (en) 2010-11-15 2015-03-10 Aquesys, Inc. Methods for treating closed angle glaucoma
US9017276B2 (en) 2010-11-15 2015-04-28 Aquesys, Inc. Shunt placement through the sclera
JP2015089490A (en) * 2013-11-07 2015-05-11 テルモ株式会社 Medical treatment instrument
US20150157836A1 (en) * 2008-01-28 2015-06-11 Peter Mats Forsell Implantable drainage device
US9095411B2 (en) 2010-11-15 2015-08-04 Aquesys, Inc. Devices for deploying intraocular shunts
US9125723B2 (en) 2013-02-19 2015-09-08 Aquesys, Inc. Adjustable glaucoma implant
US9155656B2 (en) 2012-04-24 2015-10-13 Transcend Medical, Inc. Delivery system for ocular implant
US9211181B2 (en) 2004-11-19 2015-12-15 Pulmonx Corporation Implant loading device and system
WO2016060538A1 (en) * 2014-10-17 2016-04-21 Manuel Humberto Gallardo Inzunza Valve for compensating and regulating intraocular pressure
US9358156B2 (en) 2012-04-18 2016-06-07 Invantis, Inc. Ocular implants for delivery into an anterior chamber of the eye
WO2016149425A1 (en) * 2015-03-16 2016-09-22 Da Silva Curiel Jeannette M A Method and apparatus for inserting an implant in the cornea of the eye
US20160302965A1 (en) * 2013-12-06 2016-10-20 Forsight Vision4, Inc. Implantable therapeutic devices
US9480598B2 (en) 2012-09-17 2016-11-01 Novartis Ag Expanding ocular implant devices and methods
US9510973B2 (en) 2010-06-23 2016-12-06 Ivantis, Inc. Ocular implants deployed in schlemm's canal of the eye
US9526623B2 (en) 2012-05-30 2016-12-27 Newvert Ltd. Spinal disc annulus closure device
US9554940B2 (en) 2012-03-26 2017-01-31 Glaukos Corporation System and method for delivering multiple ocular implants
US9585790B2 (en) 2013-11-14 2017-03-07 Aquesys, Inc. Intraocular shunt inserter
US9592151B2 (en) 2013-03-15 2017-03-14 Glaukos Corporation Systems and methods for delivering an ocular implant to the suprachoroidal space within an eye
US9610195B2 (en) 2013-02-27 2017-04-04 Aquesys, Inc. Intraocular shunt implantation methods and devices
US9693900B2 (en) 2013-08-06 2017-07-04 Manuel Humberto Gallardo Inzunza Intraocular pressure compensating and regulating valve
US9730638B2 (en) 2013-03-13 2017-08-15 Glaukos Corporation Intraocular physiological sensor
US9763829B2 (en) 2012-11-14 2017-09-19 Novartis Ag Flow promoting ocular implant
US9808373B2 (en) 2013-06-28 2017-11-07 Aquesys, Inc. Intraocular shunt implantation
CN107530189A (en) * 2014-12-31 2018-01-02 迈克罗欧普提克斯股份有限公司 Glaucoma treatment device and method
US9895524B2 (en) 2012-07-13 2018-02-20 Angiodynamics, Inc. Fluid bypass device for valved catheters
EP2164557B1 (en) * 2007-06-29 2018-05-30 Applied Medical Technology, Inc. Molded an undivided medical penetrating device
US9987163B2 (en) 2013-04-16 2018-06-05 Novartis Ag Device for dispensing intraocular substances
US10080682B2 (en) 2011-12-08 2018-09-25 Aquesys, Inc. Intrascleral shunt placement
US10085633B2 (en) 2012-04-19 2018-10-02 Novartis Ag Direct visualization system for glaucoma treatment
US10085884B2 (en) 2006-06-30 2018-10-02 Aquesys, Inc. Intraocular devices
US10130750B2 (en) 2004-01-29 2018-11-20 Angiodynamics, Inc. Pressure activated valve with high flow slit
US10159600B2 (en) 2013-02-19 2018-12-25 Aquesys, Inc. Adjustable intraocular flow regulation
US10159601B2 (en) 2000-05-19 2018-12-25 Ivantis, Inc. Delivery system and method of use for the eye
CN109363726A (en) * 2018-04-11 2019-02-22 中山大学中山眼科中心 The acquisition device of liquid sample with valve
WO2019082448A1 (en) * 2017-10-23 2019-05-02 株式会社ドックスネット Implant and implant system
US10342702B2 (en) 2014-08-29 2019-07-09 Camras Vision Inc. Apparatus and method for reducing intraocular pressure
US10369050B2 (en) 2014-08-29 2019-08-06 Camras Vision Inc. Device and method for reducing intraocular pressure
DE102018203356A1 (en) 2018-03-07 2019-09-12 Carl Zeiss Meditec Ag Planning device and method for generating control data for an ophthalmic laser therapy device for structures for pressure-reducing bridging of the cornea
WO2019170752A1 (en) 2018-03-07 2019-09-12 Carl Zeiss Meditec Ag Shunt implant
WO2019195419A1 (en) 2018-04-03 2019-10-10 Jack Chu A new ocular device and method for glaucoma treatment
US10463537B2 (en) 2015-06-03 2019-11-05 Aquesys Inc. Ab externo intraocular shunt placement
US10517759B2 (en) 2013-03-15 2019-12-31 Glaukos Corporation Glaucoma stent and methods thereof for glaucoma treatment
US10524958B2 (en) 2015-09-30 2020-01-07 Alievio, Inc. Method and apparatus for reducing intraocular pressure
US10610678B2 (en) 2016-08-11 2020-04-07 Angiodynamics, Inc. Bi-directional, pressure-actuated medical valve with improved fluid flow control and method of using such
US10617558B2 (en) 2012-11-28 2020-04-14 Ivantis, Inc. Apparatus for delivering ocular implants into an anterior chamber of the eye
US10667947B2 (en) 2016-06-02 2020-06-02 Aquesys, Inc. Intraocular drug delivery
US10709547B2 (en) 2014-07-14 2020-07-14 Ivantis, Inc. Ocular implant delivery system and method
US10842671B2 (en) 2010-11-15 2020-11-24 Aquesys, Inc. Intraocular shunt placement in the suprachoroidal space
US10952898B2 (en) 2018-03-09 2021-03-23 Aquesys, Inc. Intraocular shunt inserter
US10959941B2 (en) 2014-05-29 2021-03-30 Glaukos Corporation Implants with controlled drug delivery features and methods of using same
US10980667B2 (en) 2015-09-30 2021-04-20 Microoptx Inc. Eye treatment devices and methods
US11116625B2 (en) 2017-09-28 2021-09-14 Glaukos Corporation Apparatus and method for controlling placement of intraocular implants
US11135089B2 (en) 2018-03-09 2021-10-05 Aquesys, Inc. Intraocular shunt inserter
JP6971003B1 (en) * 2021-08-16 2021-11-24 裕貴 田邊 Glaucoma tube
US11197779B2 (en) 2015-08-14 2021-12-14 Ivantis, Inc. Ocular implant with pressure sensor and delivery system
US11246753B2 (en) 2017-11-08 2022-02-15 Aquesys, Inc. Manually adjustable intraocular flow regulation
WO2022049140A1 (en) 2020-09-04 2022-03-10 Carl Zeiss Meditec Ag Stent implant for treating glaucoma by means of intraocular fluid drainage from the anterior chamber
WO2022058606A1 (en) 2020-09-21 2022-03-24 Carl Zeiss Meditec, Inc. Device for positioning an implant in a target area of an eye
WO2022081609A1 (en) * 2020-10-14 2022-04-21 New World Medical, Inc. Intraocular drainage tube with valve
US11337856B2 (en) 2015-06-26 2022-05-24 Innfocus, Inc. Glaucoma device delivery system and trans-conjunctival method of delivery
US11363951B2 (en) 2011-09-13 2022-06-21 Glaukos Corporation Intraocular physiological sensor
US11540940B2 (en) 2021-01-11 2023-01-03 Alcon Inc. Systems and methods for viscoelastic delivery
US11744734B2 (en) 2007-09-24 2023-09-05 Alcon Inc. Method of implanting an ocular implant
US11925578B2 (en) 2015-09-02 2024-03-12 Glaukos Corporation Drug delivery implants with bi-directional delivery capacity
US11938058B2 (en) 2015-12-15 2024-03-26 Alcon Inc. Ocular implant and delivery system

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US15192A (en) * 1856-06-24 Tubular
US274447A (en) * 1883-03-20 William-kentish
US733152A (en) * 1902-08-30 1903-07-07 Murdoch Chisholm Empyema drainage device.
US1388172A (en) * 1920-03-18 1921-08-23 Simon M Craddock Veterinary surgical appliance
US2867213A (en) * 1957-06-12 1959-01-06 Jr Paul A Thomas Flutter valve for drainage of the pleural cavity
US3159161A (en) * 1962-11-14 1964-12-01 Ness Richard Alton Fistulizing canaliculus
US3333588A (en) * 1964-07-06 1967-08-01 Rudolf R Schulte Brain ventricle cannula
US3421509A (en) * 1965-12-17 1969-01-14 John M Fiore Urethral catheter

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US15192A (en) * 1856-06-24 Tubular
US274447A (en) * 1883-03-20 William-kentish
US733152A (en) * 1902-08-30 1903-07-07 Murdoch Chisholm Empyema drainage device.
US1388172A (en) * 1920-03-18 1921-08-23 Simon M Craddock Veterinary surgical appliance
US2867213A (en) * 1957-06-12 1959-01-06 Jr Paul A Thomas Flutter valve for drainage of the pleural cavity
US3159161A (en) * 1962-11-14 1964-12-01 Ness Richard Alton Fistulizing canaliculus
US3333588A (en) * 1964-07-06 1967-08-01 Rudolf R Schulte Brain ventricle cannula
US3421509A (en) * 1965-12-17 1969-01-14 John M Fiore Urethral catheter

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Ellis, R. A. Reduction of Intraocular Pressure Using Plastics in Surgery , in Amer. Jour. Ophthal., 50: 733 742, 1960. *
Ore, Svein et al., Preparation of Surgical Implants From Silicone Rubber by Means of a Postforming Technique. Surgery, pp. 385 390, Aug. 1962. *
Teflon Armstrong Beveled Drain Tube, Advertisement of Richards Mfg. Co., Memphis, Tenn. Copyright 1966. *

Cited By (715)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3915172A (en) * 1970-05-27 1975-10-28 Ceskoslovenska Akademie Ved Capillary drain for glaucoma
US3890976A (en) * 1972-10-26 1975-06-24 Medical Products Corp Catheter tip assembly
US3938529A (en) * 1974-07-22 1976-02-17 Gibbons Robert P Indwelling ureteral catheter
US4037604A (en) * 1976-01-05 1977-07-26 Newkirk John B Artifical biological drainage device
US4175563A (en) * 1977-10-05 1979-11-27 Arenberg Irving K Biological drainage shunt
US4808183A (en) * 1980-06-03 1989-02-28 University Of Iowa Research Foundation Voice button prosthesis and method for installing same
US4402681A (en) * 1980-08-23 1983-09-06 Haas Joseph S Artificial implant valve for the regulation of intraocular pressure
US4474569A (en) * 1982-06-28 1984-10-02 Denver Surgical Developments, Inc. Antenatal shunt
EP0102747A1 (en) * 1982-07-28 1984-03-14 Thomas C. White Ocular pressure relief device
US4554918A (en) * 1982-07-28 1985-11-26 White Thomas C Ocular pressure relief device
US4521210A (en) * 1982-12-27 1985-06-04 Wong Vernon G Eye implant for relieving glaucoma, and device and method for use therewith
US4645493A (en) * 1983-01-07 1987-02-24 N.U.S. S.R.L. Catheter for medical-surgical application
US4587954A (en) * 1983-12-29 1986-05-13 Habley Medical Technology Corporation Elastomeric prosthetic sphincter
FR2562419A1 (en) * 1984-04-06 1985-10-11 Binder Perry HYDROGEL SETON AND METHOD FOR REDUCING INTRAOCULAR PRESSURE
US4604087A (en) * 1985-02-26 1986-08-05 Joseph Neil H Aqueous humor drainage device
EP0228185A1 (en) * 1985-11-27 1987-07-08 Thomas C. White Tissue-implantable fluid-dissipating device
US4781675A (en) * 1985-11-27 1988-11-01 White Thomas C Infusion cannula
US4722724A (en) * 1986-06-23 1988-02-02 Stanley Schocket Anterior chamber tube shunt to an encircling band, and related surgical procedure
US4826478A (en) * 1986-06-23 1989-05-02 Stanley Schocket Anterior chamber tube shunt to an encircling band, and related surgical procedure
WO1989000869A1 (en) * 1987-08-06 1989-02-09 White Thomas C Glaucoma drainage in the lacrimal system
US4886488A (en) * 1987-08-06 1989-12-12 White Thomas C Glaucoma drainage the lacrimal system and method
US4813941A (en) * 1987-09-03 1989-03-21 Leslie Shea Pneumothorax treatment device
US4936825A (en) * 1988-04-11 1990-06-26 Ungerleider Bruce A Method for reducing intraocular pressure caused by glaucoma
US5372577A (en) * 1988-04-11 1994-12-13 Ungerleider; Bruce A. Apparatus for reducing intraocular pressure
US5098393A (en) * 1988-05-31 1992-03-24 Kurt Amplatz Medical introducer and valve assembly
US5064417A (en) * 1988-10-11 1991-11-12 Co Pharma Corporation S.R.L. Device for fastening a catheter to a cranial theca for performing cerebro spinal fluid drainage to the outside operations
US4968296A (en) * 1989-12-20 1990-11-06 Robert Ritch Transscleral drainage implant device for the treatment of glaucoma
US5092837A (en) * 1989-12-20 1992-03-03 Robert Ritch Method for the treatment of glaucoma
US5397300A (en) * 1990-05-31 1995-03-14 Iovision, Inc. Glaucoma implant
US5178604A (en) * 1990-05-31 1993-01-12 Iovision, Inc. Glaucoma implant
US5476445A (en) * 1990-05-31 1995-12-19 Iovision, Inc. Glaucoma implant with a temporary flow restricting seal
US5558629A (en) * 1990-05-31 1996-09-24 Iovision, Inc. Glaucoma implant
US5207660A (en) * 1991-04-26 1993-05-04 Cornell Research Foundation, Inc. Method for the delivery of compositions to the ocular tissues
WO1993003778A1 (en) * 1991-08-14 1993-03-04 Price Francis W Jr Eye filtration prosthesis for relieving intraocular pressure
US5171213A (en) * 1991-08-14 1992-12-15 Price Jr Francis W Technique for fistulization of the eye and an eye filtration prosthesis useful therefor
US5221278A (en) * 1992-03-12 1993-06-22 Alza Corporation Osmotically driven delivery device with expandable orifice for pulsatile delivery effect
US5318558A (en) * 1992-03-12 1994-06-07 Alza Corporation Osmotically driven delivery device with expandable orifice for pulsatile delivery effect
US5626559A (en) * 1994-05-02 1997-05-06 Ramot University Authority For Applied Research And Industrial Development Ltd. Ophthalmic device for draining excess intraocular fluid
US5807303A (en) * 1994-12-09 1998-09-15 Xomed Surgical Products, Inc. Valve assembly and device for relieving synovial fluid pressure
WO1996018357A3 (en) * 1994-12-09 1996-09-06 F Barry Bays Valve assembly and method for relieving synovial fluid pressure
US5769093A (en) * 1994-12-09 1998-06-23 Xomed Surgical Products, Inc. Method of relieving synovial fluid pressure
WO1996018357A2 (en) * 1994-12-09 1996-06-20 Bays F Barry Valve assembly and method for relieving synovial fluid pressure
JPH10510446A (en) * 1994-12-09 1998-10-13 ベイズ,エフ・バリー Valve assembly and method for releasing joint synovial fluid pressure
US5660205A (en) * 1994-12-15 1997-08-26 Epstein; Alan B. One-way valve
GB2296663A (en) * 1995-01-03 1996-07-10 Ahmed Salih Mahmud Drainage device for alleviating excess ophthalmic fluid pressure
US6936023B2 (en) 1995-04-26 2005-08-30 Medtronic Xomed, Inc. Composite ventilation tube
US6692455B2 (en) 1995-04-26 2004-02-17 Medtronic Xomed, Inc. Composite ventilation tube
US6939494B2 (en) 1995-04-26 2005-09-06 Medtronic Xomed, Inc. Method of making ventilation tube
US20040077989A1 (en) * 1995-04-26 2004-04-22 Goode Richard L. Composite ventilation tube
US6508779B1 (en) 1995-05-05 2003-01-21 John Suson Adjustable flow rate glaucoma shunt and method of using same
US5626558A (en) * 1995-05-05 1997-05-06 Suson; John Adjustable flow rate glaucoma shunt and method of using same
CN1124164C (en) * 1995-05-14 2003-10-15 奥普通诺尔有限公司 Intraocular implant, delivery device, and method of implantation
US20040088048A1 (en) * 1995-05-14 2004-05-06 Jacob Richter Intraocular implant, delivery device, and method of implantation
EP1473004A2 (en) 1995-05-14 2004-11-03 Optonol Ltd. Ophtalmic implant for treating glaucoma and delivery device
US6468283B1 (en) * 1995-05-14 2002-10-22 Optonol, Ltd. Method of regulating pressure with an intraocular implant
JPH11505159A (en) * 1995-05-14 1999-05-18 オプトノール リミティド Intraocular implant, introduction device, and method of implantation
US7481816B2 (en) * 1995-05-14 2009-01-27 Optonol Ltd. Intraocular implant, delivery device, and method of implantation
US5702414A (en) * 1995-05-14 1997-12-30 Optonol Ltd Method of implanting an intraocular implant
US5968058A (en) * 1996-03-27 1999-10-19 Optonol Ltd. Device for and method of implanting an intraocular implant
EP0967946A1 (en) * 1996-11-29 2000-01-05 The Lions Eye Institute of Western Australia Incorporated Biological microfistula tube and implantation method and apparatus
EP0967946A4 (en) * 1996-11-29 2000-11-08 Lions Eye Inst Australia Inc Biological microfistula tube and implantation method and apparatus
JP2001504732A (en) * 1996-11-29 2001-04-10 ザ ライオンズ アイ インスティチュート オブ ウェスタン オーストラリア インコーポレイテッド Biological micro fistula tube, transplantation method and transplantation device
US6544249B1 (en) 1996-11-29 2003-04-08 The Lions Eye Institute Of Western Australia Incorporated Biological microfistula tube and implantation method and apparatus
US6258060B1 (en) 1997-02-07 2001-07-10 Abbeymoon Medical, Inc. Urethral apparatus with position indicator and methods of use thereof
US8136520B2 (en) 1997-04-30 2012-03-20 Pulmonx Corporation Occlusion device
US7670373B1 (en) 1997-04-30 2010-03-02 Pulmonx Corporation Occlusion device
US20070005083A1 (en) * 1997-04-30 2007-01-04 Sabaratham Sabanathan Occlusion device
US6050970A (en) * 1997-05-08 2000-04-18 Pharmacia & Upjohn Company Method and apparatus for inserting a glaucoma implant in an anterior and posterior segment of the eye
US6221060B1 (en) 1997-08-19 2001-04-24 Abbeymoor Medical, Inc. Urethral device with anchoring system
US5971967A (en) * 1997-08-19 1999-10-26 Abbeymoor Medical, Inc. Urethral device with anchoring system
WO1999008741A1 (en) * 1997-08-19 1999-02-25 Abbeymoor Medical, Inc. Urethral device with anchoring system
US6004302A (en) * 1997-08-28 1999-12-21 Brierley; Lawrence A. Cannula
US20020095209A1 (en) * 1997-09-16 2002-07-18 Gholam-Reza Zadno-Azizi Body fluid flow control device
US7033387B2 (en) 1997-09-16 2006-04-25 Emphasys Medical, Inc. Body fluid flow control device
US6632243B1 (en) 1997-09-16 2003-10-14 Emphasys Medical Inc. Body fluid flow control device
US20030199972A1 (en) * 1997-09-16 2003-10-23 Gholam-Reza Zadno-Azizi Body fluid flow control device
US7276077B2 (en) 1997-09-16 2007-10-02 Emphasys Medical, Inc. Body fluid flow control device
US20030212452A1 (en) * 1997-09-16 2003-11-13 Gholam-Reza Zadno-Azizi Body fluid flow control device
EP2319469A1 (en) 1997-11-20 2011-05-11 Optonol Ltd. Flow regulating implant, method of manufacturing, and delivery device
US8486086B2 (en) 1997-11-20 2013-07-16 Optonol, Ltd Flow regulating implant, method of manufacture, and delivery device
JP2001523519A (en) * 1997-11-20 2001-11-27 オプトノール リミティド Implant for flow control, manufacturing method and dosing device
US20030079329A1 (en) * 1997-11-20 2003-05-01 Ira Yaron Flow regulating implant, method of manufacture, and delivery device
US20100274259A1 (en) * 1997-11-20 2010-10-28 Optonol Ltd. Fluid drainage device, delivery device, and associated methods of use and manufacture
US6510600B2 (en) 1997-11-20 2003-01-28 Optonol, Ltd. Method for manufacturing a flow regulating implant
US7670310B2 (en) 1997-11-20 2010-03-02 Optonol Ltd Flow regulating implants
US6203513B1 (en) 1997-11-20 2001-03-20 Optonol Ltd. Flow regulating implant, method of manufacture, and delivery device
US8313454B2 (en) * 1997-11-20 2012-11-20 Optonol Ltd. Fluid drainage device, delivery device, and associated methods of use and manufacture
US20080125691A1 (en) * 1997-11-20 2008-05-29 Optonol Ltd. Flow regulating implants
US7850637B2 (en) * 1999-04-26 2010-12-14 Glaukos Corporation Shunt device and method for treating glaucoma
US8771217B2 (en) * 1999-04-26 2014-07-08 Glaukos Corporation Shunt device and method for treating ocular disorders
US10568762B2 (en) 1999-04-26 2020-02-25 Glaukos Corporation Stent for treating ocular disorders
US6626858B2 (en) 1999-04-26 2003-09-30 Gmp Vision Solutions, Inc. Shunt device and method for treating glaucoma
US9827143B2 (en) 1999-04-26 2017-11-28 Glaukos Corporation Shunt device and method for treating ocular disorders
US20050119601A9 (en) * 1999-04-26 2005-06-02 Lynch Mary G. Shunt device and method for treating glaucoma
US10492950B2 (en) 1999-04-26 2019-12-03 Glaukos Corporation Shunt device and method for treating ocular disorders
WO2000064393A1 (en) * 1999-04-26 2000-11-02 Lynch Mary G Shunt device and method for treating glaucoma
US6783544B2 (en) 1999-04-26 2004-08-31 Gmp Vision Solutions, Inc. Stent device and method for treating glaucoma
US8388568B2 (en) 1999-04-26 2013-03-05 Glaukos Corporation Shunt device and method for treating ocular disorders
US6827699B2 (en) 1999-04-26 2004-12-07 Gmp Vision Solutions, Inc. Shunt device and method for treating glaucoma
US20100004580A1 (en) * 1999-04-26 2010-01-07 Glaukos Corporation Shunt device and method for treating ocular disorders
US6827700B2 (en) 1999-04-26 2004-12-07 Gmp Vision Solutions, Inc. Shunt device and method for treating glaucoma
WO2000064391A1 (en) * 1999-04-26 2000-11-02 Lynch Mary G Stent device and method for treating glaucoma
EP1477146A3 (en) * 1999-04-26 2004-12-15 Gmp Vision Solutions, Inc. Shunt device and method for treating glaucoma
US20030236484A1 (en) * 1999-04-26 2003-12-25 Gmp Vision Solutions, Inc. Inflatable device and method for treating glaucoma
US8152752B2 (en) 1999-04-26 2012-04-10 Glaukos Corporation Shunt device and method for treating glaucoma
US20110196281A1 (en) * 1999-04-26 2011-08-11 Glaukos Corporation Shunt device and method for treating ocular disorders
US7220238B2 (en) * 1999-04-26 2007-05-22 Gmp Vision Solutions, Inc. Shunt device and method for treating glaucoma
US6450984B1 (en) 1999-04-26 2002-09-17 Gmp Vision Solutions, Inc. Shunt device and method for treating glaucoma
US6464724B1 (en) 1999-04-26 2002-10-15 Gmp Vision Solutions, Inc. Stent device and method for treating glaucoma
US20050038334A1 (en) * 1999-04-26 2005-02-17 Lynch Mary G. Shunt device and method for treating glaucoma
US9492320B2 (en) 1999-04-26 2016-11-15 Glaukos Corporation Shunt device and method for treating ocular disorders
US20030055372A1 (en) * 1999-04-26 2003-03-20 Lynch Mary G. Shunt device and method for treating glaucoma
US20050090806A1 (en) * 1999-04-26 2005-04-28 Gmp Vision Solutions Inc. Shunt device and method for treating glaucoma
US20050090807A1 (en) * 1999-04-26 2005-04-28 Gmp Vision Solutions, Inc. Shunt device and method for treating glaucoma
US6558342B1 (en) 1999-06-02 2003-05-06 Optonol Ltd. Flow control device, introducer and method of implanting
US6726664B2 (en) 1999-06-02 2004-04-27 Optonol Ltd. Flow control device, introducer and method of implanting
US6293951B1 (en) * 1999-08-24 2001-09-25 Spiration, Inc. Lung reduction device, system, and method
US20050119737A1 (en) * 2000-01-12 2005-06-02 Bene Eric A. Ocular implant and methods for making and using same
JP2003520077A (en) * 2000-01-12 2003-07-02 ベクトン・ディキンソン・アンド・カンパニー Systems and methods for reducing intraocular pressure
US20080161741A1 (en) * 2000-01-12 2008-07-03 Becton, Dickinson And Company Ocular implant and methods for making and using same
US6840243B2 (en) * 2000-03-04 2005-01-11 Emphasys Medical, Inc. Methods and devices for use in performing pulmonary procedures
US6901927B2 (en) 2000-03-04 2005-06-07 Emphasys Medical, Inc. Methods and devices for use in performing pulmonary procedures
US7165548B2 (en) 2000-03-04 2007-01-23 Emphasys Medical, Inc. Methods and devices for use in performing pulmonary procedures
US6679264B1 (en) 2000-03-04 2004-01-20 Emphasys Medical, Inc. Methods and devices for use in performing pulmonary procedures
US20050051163A1 (en) * 2000-03-04 2005-03-10 Deem Mark E. Methods and devices for use in performing pulmonary procedures
US20110226238A1 (en) * 2000-03-04 2011-09-22 Pulmonx Corporation Implanted bronchial isolation devices and methods
US20040134487A1 (en) * 2000-03-04 2004-07-15 Deem Mark E. Methods and devices for use in performing pulmonary procedures
US6694979B2 (en) 2000-03-04 2004-02-24 Emphasys Medical, Inc. Methods and devices for use in performing pulmonary procedures
US8357139B2 (en) 2000-03-04 2013-01-22 Pulmonx Corporation Methods and devices for use in performing pulmonary procedures
US7662181B2 (en) 2000-03-04 2010-02-16 Pulmonx Corporation Methods and devices for use in performing pulmonary procedures
US8474460B2 (en) 2000-03-04 2013-07-02 Pulmonx Corporation Implanted bronchial isolation devices and methods
US6904909B2 (en) 2000-03-04 2005-06-14 Emphasys Medical, Inc. Methods and devices for use in performing pulmonary procedures
US20060174870A1 (en) * 2000-03-04 2006-08-10 Deem Mark E Methods and devices for use in performing pulmonary procedures
US20030192550A1 (en) * 2000-03-04 2003-10-16 Deem Mark E. Methods and devices for use in performing pulmonary procedures
US20030192551A1 (en) * 2000-03-04 2003-10-16 Deem Mark E. Methods and devices for use in performing pulmonary procedures
US20090137983A1 (en) * 2000-04-14 2009-05-28 Glaukos Corporation Implant delivery device and methods thereof for treatment of ocular disorders
US10485702B2 (en) 2000-04-14 2019-11-26 Glaukos Corporation System and method for treating an ocular disorder
US20040210185A1 (en) * 2000-04-14 2004-10-21 Hosheng Tu Glaucoma implant kit
US20080234624A2 (en) * 2000-04-14 2008-09-25 Glaukos Corporation Ocular implant with anchor and therapeutic agent
US20050277864A1 (en) * 2000-04-14 2005-12-15 David Haffner Injectable gel implant for glaucoma treatment
US20100234790A1 (en) * 2000-04-14 2010-09-16 Glaukos Corporation Ocular implant with therapeutic agents and methods thereof
US6780164B2 (en) 2000-04-14 2004-08-24 Glaukos Corporation L-shaped implant with bi-directional flow
US8333742B2 (en) 2000-04-14 2012-12-18 Glaukos Corporation Method of delivering an implant for treating an ocular disorder
US20040249333A1 (en) * 2000-04-14 2004-12-09 Bergheim Olav B. Glaucoma implant with bi-directional flow
US8273050B2 (en) 2000-04-14 2012-09-25 Glaukos Corporation Ocular implant with anchor and therapeutic agent
US20040254519A1 (en) * 2000-04-14 2004-12-16 Hosheng Tu Glaucoma treatment device
US20040127843A1 (en) * 2000-04-14 2004-07-01 Hosheng Tu Glaucoma implant with therapeutic agents
US20110105987A1 (en) * 2000-04-14 2011-05-05 Glaukos Corporation System and method for treating an ocular disorder
US20040111050A1 (en) * 2000-04-14 2004-06-10 Gregory Smedley Implantable ocular pump to reduce intraocular pressure
US8348877B2 (en) 2000-04-14 2013-01-08 Dose Medical Corporation Ocular implant with therapeutic agents and methods thereof
US6736791B1 (en) 2000-04-14 2004-05-18 Glaukos Corporation Glaucoma treatment device
US6955656B2 (en) 2000-04-14 2005-10-18 Glaukos Corporation Apparatus and method for treating glaucoma
US8801648B2 (en) 2000-04-14 2014-08-12 Glaukos Corporation Ocular implant with anchor and methods thereof
US7708711B2 (en) 2000-04-14 2010-05-04 Glaukos Corporation Ocular implant with therapeutic agents and methods thereof
US20050049578A1 (en) * 2000-04-14 2005-03-03 Hosheng Tu Implantable ocular pump to reduce intraocular pressure
US8808219B2 (en) 2000-04-14 2014-08-19 Glaukos Corporation Implant delivery device and methods thereof for treatment of ocular disorders
US20050209549A1 (en) * 2000-04-14 2005-09-22 Bergheim Olav B Glaucoma implant with multiple openings
US20050209550A1 (en) * 2000-04-14 2005-09-22 Bergheim Olav B Method of treating glaucoma using an implant having a uniform diameter between the anterior chamber and Schlemm's canal
US9993368B2 (en) 2000-04-14 2018-06-12 Glaukos Corporation System and method for treating an ocular disorder
US20100056979A1 (en) * 2000-04-14 2010-03-04 Glaukos Corporation Implantable ocular pump to reduce intraocular pressure
US20100010414A1 (en) * 2000-04-14 2010-01-14 Glaukos Corporation Method of delivering an implant for treating an ocular disorder
US8814820B2 (en) 2000-04-14 2014-08-26 Glaukos Corporation Ocular implant with therapeutic agent and methods thereof
US20030187385A1 (en) * 2000-04-14 2003-10-02 Bergheim Olav B. Implant with anchor
US20030181848A1 (en) * 2000-04-14 2003-09-25 Bergheim Olav B. Implant with drug coating
US9789001B2 (en) 2000-04-14 2017-10-17 Dose Medical Corporation Ocular implant with therapeutic agents and methods thereof
US7867205B2 (en) 2000-04-14 2011-01-11 Glaukos Corporation Method of delivering an implant for treating an ocular disorder
US7297130B2 (en) 2000-04-14 2007-11-20 Glaukos Corporation Implant with anchor
US20070282244A1 (en) * 2000-04-14 2007-12-06 Glaukos Corporation Glaucoma implant with anchor
US20070282245A1 (en) * 2000-04-14 2007-12-06 Glaukos Corporation Glaucoma implant with valve
EP2985012A1 (en) * 2000-04-14 2016-02-17 Glaukos Corporation Implant for treating ocular disorders
US9066782B2 (en) 2000-04-14 2015-06-30 Dose Medical Corporation Ocular implant with therapeutic agents and methods thereof
US10335314B2 (en) 2000-05-19 2019-07-02 Ivantis, Inc. Delivery system and method of use for the eye
US10687978B2 (en) 2000-05-19 2020-06-23 Ivantis, Inc. Delivery system and method of use for the eye
US10159601B2 (en) 2000-05-19 2018-12-25 Ivantis, Inc. Delivery system and method of use for the eye
US10390993B1 (en) 2000-05-19 2019-08-27 Ivantis, Inc. Delivery system and method of use for the eye
EP1184010A3 (en) * 2000-08-29 2003-12-03 Aixmed Gesellschaft für Medizintechnik mbH Aqueous humour drainage device
US6730056B1 (en) * 2000-09-21 2004-05-04 Motorola, Inc. Eye implant for treating glaucoma and method for manufacturing same
US20040073156A1 (en) * 2001-01-09 2004-04-15 Brown J. David Glaucoma treatment device and method
US20060079828A1 (en) * 2001-01-09 2006-04-13 Brown J D Glaucoma treatment device and method
US20100168644A1 (en) * 2001-01-09 2010-07-01 Brown J David Glaucoma Treatment Device and Method
US20060276739A1 (en) * 2001-01-09 2006-12-07 Brown J D Glaucoma treatment device and method
WO2002070045A1 (en) * 2001-01-09 2002-09-12 Brown J David Glaucoma treatment device and method
US6881198B2 (en) 2001-01-09 2005-04-19 J. David Brown Glaucoma treatment device and method
US6595945B2 (en) * 2001-01-09 2003-07-22 J. David Brown Glaucoma treatment device and method
US20020112729A1 (en) * 2001-02-21 2002-08-22 Spiration, Inc. Intra-bronchial obstructing device that controls biological interaction with the patient
US7011094B2 (en) 2001-03-02 2006-03-14 Emphasys Medical, Inc. Bronchial flow control devices and methods of use
US7798147B2 (en) 2001-03-02 2010-09-21 Pulmonx Corporation Bronchial flow control devices with membrane seal
US20040055606A1 (en) * 2001-03-02 2004-03-25 Emphasys Medical, Inc. Bronchial flow control devices with membrane seal
US20040074491A1 (en) * 2001-03-02 2004-04-22 Michael Hendricksen Delivery methods and devices for implantable bronchial isolation devices
US20110017207A1 (en) * 2001-03-02 2011-01-27 Pulmonx Corporation Bronchial flow control devices with membrane seal
US20040060563A1 (en) * 2001-03-02 2004-04-01 Alan Rapacki Bronchial flow control devices and methods of use
US8251067B2 (en) 2001-03-02 2012-08-28 Pulmonx Corporation Bronchial flow control devices with membrane seal
US20020143284A1 (en) * 2001-04-03 2002-10-03 Hosheng Tu Drug-releasing trabecular implant for glaucoma treatment
US10406029B2 (en) * 2001-04-07 2019-09-10 Glaukos Corporation Ocular system with anchoring implant and therapeutic agent
US20090036819A1 (en) * 2001-04-07 2009-02-05 Glaukos Corporation Drug eluting ocular implant with anchor and methods thereof
US8579846B2 (en) 2001-04-07 2013-11-12 Glaukos Corporation Ocular implant systems
US20070112292A1 (en) * 2001-04-07 2007-05-17 Hosheng Tu Glaucoma stent and methods thereof for glaucoma treatment
US8075511B2 (en) 2001-04-07 2011-12-13 Glaukos Corporation System for treating ocular disorders and methods thereof
US10828473B2 (en) 2001-04-07 2020-11-10 Glaukos Corporation Ocular implant delivery system and methods thereof
US8062244B2 (en) 2001-04-07 2011-11-22 Glaukos Corporation Self-trephining implant and methods thereof for treatment of ocular disorders
US20040254520A1 (en) * 2001-04-07 2004-12-16 Eric Porteous Coil implant for glaucoma treatment
US9987472B2 (en) 2001-04-07 2018-06-05 Glaukos Corporation Ocular implant delivery systems
US9572963B2 (en) 2001-04-07 2017-02-21 Glaukos Corporation Ocular disorder treatment methods and systems
US20160100983A1 (en) * 2001-04-07 2016-04-14 Glaukos Corporation Ocular system with anchoring implant and therapeutic agent
WO2002080811A3 (en) * 2001-04-07 2004-03-11 Glaukos Corp Glaucoma stent and methods thereof for glaucoma treatment
US8118768B2 (en) 2001-04-07 2012-02-21 Dose Medical Corporation Drug eluting ocular implant with anchor and methods thereof
US7563241B2 (en) 2001-04-07 2009-07-21 Glaukos Corporation Implant and methods thereof for treatment of ocular disorders
US20020188308A1 (en) * 2001-04-07 2002-12-12 Hosheng Tu Glaucoma stent and methods thereof for glaucoma treatment
US20090138022A1 (en) * 2001-04-07 2009-05-28 Glaukos Corporation Ocular implant delivery system and method thereof
EP1418868A4 (en) * 2001-04-07 2006-11-22 Glaukos Corp Glaucoma stent and methods thereof for glaucoma treatment
US7135009B2 (en) 2001-04-07 2006-11-14 Glaukos Corporation Glaucoma stent and methods thereof for glaucoma treatment
EP1418868A2 (en) * 2001-04-07 2004-05-19 Glaukos Corporation Glaucoma stent and methods thereof for glaucoma treatment
US20110092878A1 (en) * 2001-04-07 2011-04-21 Glaukos Corporation Ocular implant delivery system and methods thereof
JP2009056324A (en) * 2001-04-07 2009-03-19 Glaukos Corp System for treating abnormal condition of eye
US9155654B2 (en) 2001-04-07 2015-10-13 Glaukos Corporation Ocular system with anchoring implant and therapeutic agent
AU2002258754B2 (en) * 2001-04-07 2006-08-17 Glaukos Corporation Glaucoma stent and methods thereof for glaucoma treatment
US7857782B2 (en) 2001-04-07 2010-12-28 Glaukos Corporation Ocular implant delivery system and method thereof
JP2016135275A (en) * 2001-04-07 2016-07-28 グローコス コーポレーション System for treating ocular disorders
JP2013066742A (en) * 2001-04-07 2013-04-18 Glaukos Corp Glaucoma stent and method for treating glaucoma
US7678065B2 (en) 2001-05-02 2010-03-16 Glaukos Corporation Implant with intraocular pressure sensor for glaucoma treatment
US20050119636A1 (en) * 2001-05-02 2005-06-02 David Haffner Implant with intraocular pressure sensor for glaucoma treatment
US6666841B2 (en) 2001-05-02 2003-12-23 Glaukos Corporation Bifurcatable trabecular shunt for glaucoma treatment
US6981958B1 (en) 2001-05-02 2006-01-03 Glaukos Corporation Implant with pressure sensor for glaucoma treatment
US20100106073A1 (en) * 2001-05-02 2010-04-29 Glaukos Corporation Method of monitoring intraocular pressure and treating an ocular disorder
US20050192527A1 (en) * 2001-05-02 2005-09-01 Morteza Gharib Glaucoma implant with extending members
US20090076436A2 (en) * 2001-05-02 2009-03-19 Glaukos Corporation Ocular implants with deployable structure
US8142364B2 (en) 2001-05-02 2012-03-27 Dose Medical Corporation Method of monitoring intraocular pressure and treating an ocular disorder
US7094225B2 (en) 2001-05-03 2006-08-22 Glaukos Corporation Medical device and methods of use of glaucoma treatment
US20080015488A1 (en) * 2001-05-03 2008-01-17 Glaukos Corporation Glaucoma implant with double anchor mechanism
US7273475B2 (en) 2001-05-03 2007-09-25 Glaukos Corporation Medical device and methods of use for glaucoma treatment
US20020169130A1 (en) * 2001-05-03 2002-11-14 Hosheng Tu Medical device and methods of use for glaucoma treatment
US8337445B2 (en) 2001-05-03 2012-12-25 Glaukos Corporation Ocular implant with double anchor mechanism
US10285856B2 (en) 2001-08-28 2019-05-14 Glaukos Corporation Implant delivery system and methods thereof for treating ocular disorders
US20060241749A1 (en) * 2001-08-28 2006-10-26 Hosheng Tu Glaucoma stent system
US20040050392A1 (en) * 2001-08-28 2004-03-18 Hosheng Tu Glaucoma stent for treating glaucoma and methods of use
US7331984B2 (en) 2001-08-28 2008-02-19 Glaukos Corporation Glaucoma stent for treating glaucoma and methods of use
US20070010827A1 (en) * 2001-08-28 2007-01-11 Hosheng Tu Glaucoma stent system
US9561131B2 (en) 2001-08-28 2017-02-07 Glaukos Corporation Implant delivery system and methods thereof for treating ocular disorders
US7879079B2 (en) 2001-08-28 2011-02-01 Glaukos Corporation Implant delivery system and methods thereof for treating ocular disorders
US20050033310A1 (en) * 2001-09-11 2005-02-10 Alferness Clifton A. Intra-bronchial valve devices
US20110054632A1 (en) * 2001-09-11 2011-03-03 Spiration, Inc. Removable lung reduction devices, systems, and methods
US20040206349A1 (en) * 2001-09-11 2004-10-21 Alferness Clifton A. Removable lung reduction devices, systems, and methods
US20040243140A1 (en) * 2001-09-11 2004-12-02 Alferness Clifton A. Collapsible intra-bronchial valve devices
US20030050648A1 (en) * 2001-09-11 2003-03-13 Spiration, Inc. Removable lung reduction devices, systems, and methods
US20090205667A1 (en) * 2001-09-11 2009-08-20 Spiration, Inc. Removable lung reduction devices, systems, and methods
US7757692B2 (en) 2001-09-11 2010-07-20 Spiration, Inc. Removable lung reduction devices, systems, and methods
US8414655B2 (en) 2001-09-11 2013-04-09 Spiration, Inc. Removable lung reduction devices, systems, and methods
US8974484B2 (en) 2001-09-11 2015-03-10 Spiration, Inc. Removable lung reduction devices, systems, and methods
US20040211412A1 (en) * 2001-09-11 2004-10-28 Alferness Clifton A. Removable lung reduction devices, systems, and method
US20050166925A1 (en) * 2001-10-11 2005-08-04 Emphasys Medical, Inc., A California Corporation Bronchial flow control devices and methods of use
US7854228B2 (en) 2001-10-11 2010-12-21 Pulmonx Corporation Bronchial flow control devices and methods of use
US20050145253A1 (en) * 2001-10-11 2005-07-07 Emphasys Medical, Inc., A Delaware Corporation Bronchial flow control devices and methods of use
US6941950B2 (en) 2001-10-11 2005-09-13 Emphasys Medical, Inc. Bronchial flow control devices and methods of use
US20110130834A1 (en) * 2001-10-11 2011-06-02 Pulmonx Corporation Bronchial flow control devices and methods of use
US20030070682A1 (en) * 2001-10-11 2003-04-17 Wilson Peter M. Bronchial flow control devices and methods of use
US20070185531A1 (en) * 2001-10-25 2007-08-09 Spiration, Inc. Apparatus and method for deployment of a bronchial obstruction device
US7896887B2 (en) 2001-10-25 2011-03-01 Spiration, Inc. Apparatus and method for deployment of a bronchial obstruction device
US20110203581A1 (en) * 2001-10-25 2011-08-25 Spiration, Inc. Apparatus and method for deployment of a bronchial obstruction device
US8986336B2 (en) 2001-10-25 2015-03-24 Spiration, Inc. Apparatus and method for deployment of a bronchial obstruction device
US20030097151A1 (en) * 2001-10-25 2003-05-22 Smedley Gregory T. Apparatus and mitochondrial treatment for glaucoma
US20030183235A1 (en) * 2001-10-25 2003-10-02 Spiration, Inc. Bronchial obstruction device deployment system and method
US20030088260A1 (en) * 2001-11-08 2003-05-08 Smedley Gregory T. Combined treatment for cataract and glaucoma treatment
US7163543B2 (en) 2001-11-08 2007-01-16 Glaukos Corporation Combined treatment for cataract and glaucoma treatment
US20030135149A1 (en) * 2002-01-13 2003-07-17 Cheryl Cullen Sinus valved glaucoma shunt
US6966888B2 (en) * 2002-01-13 2005-11-22 Eagle Vision, Inc. Sinus valved glaucoma shunt
US20030158515A1 (en) * 2002-02-21 2003-08-21 Spiration, Inc. Device and method for intra-bronchial provision of a therapeutic agent
US20060074382A1 (en) * 2002-02-21 2006-04-06 Gonzalez Hugo X Device and method for intra-bronchial provision of a therapeutic agent
US20060235432A1 (en) * 2002-02-21 2006-10-19 Devore Lauri J Intra-bronchial obstructing device that controls biological interaction with the patient
US7942931B2 (en) 2002-02-21 2011-05-17 Spiration, Inc. Device and method for intra-bronchial provision of a therapeutic agent
US20060200076A1 (en) * 2002-02-21 2006-09-07 Gonzalez Hugo X Device and method for intra-bronchial provision of a therapeutic agent
US20060206147A1 (en) * 2002-02-21 2006-09-14 Devore Lauri J Intra-bronchial obstruction device that provides a medicant intra-bronchially to the patient
US6929637B2 (en) 2002-02-21 2005-08-16 Spiration, Inc. Device and method for intra-bronchial provision of a therapeutic agent
US7186232B1 (en) 2002-03-07 2007-03-06 Glaukoa Corporation Fluid infusion methods for glaucoma treatment
US9220632B2 (en) 2002-03-07 2015-12-29 Glaukos Corporation Fluid infusion methods for ocular disorder treatment
US8617094B2 (en) 2002-03-07 2013-12-31 Glaukos Corporation Fluid infusion methods for glaucoma treatment
US20030228344A1 (en) * 2002-03-08 2003-12-11 Fields Antony J. Methods and devices for inducing collapse in lung regions fed by collateral pathways
US20060283462A1 (en) * 2002-03-08 2006-12-21 Fields Antony J Methods and devices for inducing collapse in lung regions fed by collateral pathways
US20080249503A1 (en) * 2002-03-08 2008-10-09 Fields Antony J Methods and devices for lung treatment
US7412977B2 (en) 2002-03-08 2008-08-19 Emphasys Medical, Inc. Methods and devices for inducing collapse in lung regions fed by collateral pathways
US7507258B2 (en) 2002-03-11 2009-03-24 Oded Nahleili Polymeric stent useful for the treatment of the salivary gland ducts and method for using the same
US7195646B2 (en) * 2002-03-11 2007-03-27 Oded Nahleili Polymeric stent useful for the treatment of the salivary gland ducts and method for using the same
US20070162148A1 (en) * 2002-03-11 2007-07-12 Oded Nahlieli Polymeric stent useful for the treatment of the salivary gland ducts and method for using the same
US20050125071A1 (en) * 2002-03-11 2005-06-09 Oded Nahleili Polymeric stent useful for the treatment of the salivary gland ducts and method for using the same
US20090105841A1 (en) * 2002-03-11 2009-04-23 Oded Nahlieli Polymeric stent useful for the treatment of the salivary gland ducts and method for using the same
US8882781B2 (en) 2002-03-15 2014-11-11 Glaukos Corporation Combined treatment for cataract and glaucoma treatment
US7951155B2 (en) 2002-03-15 2011-05-31 Glaukos Corporation Combined treatment for cataract and glaucoma treatment
US20030181922A1 (en) * 2002-03-20 2003-09-25 Spiration, Inc. Removable anchored lung volume reduction devices and methods
US20080119866A1 (en) * 2002-03-20 2008-05-22 Alferness Clifton A Removable anchored lung volume reduction devices and methods
US8926647B2 (en) 2002-03-20 2015-01-06 Spiration, Inc. Removable anchored lung volume reduction devices and methods
US8177805B2 (en) 2002-03-20 2012-05-15 Spiration, Inc. Removable anchored lung volume reduction devices and methods
US8021385B2 (en) 2002-03-20 2011-09-20 Spiration, Inc. Removable anchored lung volume reduction devices and methods
US9597230B2 (en) 2002-04-08 2017-03-21 Glaukos Corporation Devices and methods for glaucoma treatment
US9301875B2 (en) 2002-04-08 2016-04-05 Glaukos Corporation Ocular disorder treatment implants with multiple opening
US20050266047A1 (en) * 2002-04-08 2005-12-01 Hosheng Tu Injectable glaucoma implants with multiple openings
US7879001B2 (en) 2002-04-08 2011-02-01 Glaukos Corporation Devices and methods for treatment of ocular disorders
US20040102729A1 (en) * 2002-04-08 2004-05-27 David Haffner Devices and methods for glaucoma treatment
US20040147870A1 (en) * 2002-04-08 2004-07-29 Burns Thomas W. Glaucoma treatment kit
US7431710B2 (en) 2002-04-08 2008-10-07 Glaukos Corporation Ocular implants with anchors and methods thereof
US20050271704A1 (en) * 2002-04-08 2005-12-08 Hosheng Tu Injectable glaucoma implants with multiple openings
US7867186B2 (en) 2002-04-08 2011-01-11 Glaukos Corporation Devices and methods for treatment of ocular disorders
US10485701B2 (en) 2002-04-08 2019-11-26 Glaukos Corporation Devices and methods for glaucoma treatment
US20060235467A1 (en) * 2002-04-16 2006-10-19 Devore Lauri J Removable anchored lung volume reduction device and methods
US20030195385A1 (en) * 2002-04-16 2003-10-16 Spiration, Inc. Removable anchored lung volume reduction devices and methods
US20040024345A1 (en) * 2002-04-19 2004-02-05 Morteza Gharib Glaucoma implant with valveless flow bias
US20030212412A1 (en) * 2002-05-09 2003-11-13 Spiration, Inc. Intra-bronchial obstructing device that permits mucus transport
US20110079221A1 (en) * 2002-05-17 2011-04-07 Spiration, Inc. One-way valve devices for anchored implantation in a lung
US7842061B2 (en) 2002-05-17 2010-11-30 Spiration, Inc. Methods of achieving lung volume reduction with removable anchored devices
US20030216769A1 (en) * 2002-05-17 2003-11-20 Dillard David H. Removable anchored lung volume reduction devices and methods
US20040143282A1 (en) * 2002-05-17 2004-07-22 Dillard David H. Methods of achieving lung volume reduction with removable anchored devices
US7875048B2 (en) 2002-05-17 2011-01-25 Spiration, Inc. One-way valve devices for anchored implantation in a lung
US7434578B2 (en) 2002-05-17 2008-10-14 Spiration, Inc. Methods of achieving lung volume reduction with removable anchored devices
US8956319B2 (en) 2002-05-17 2015-02-17 Spiration, Inc. One-way valve devices for anchored implantation in a lung
US8257381B2 (en) 2002-05-17 2012-09-04 Spiration, Inc. One-way valve devices for anchored implantation in a lung
US20050033344A1 (en) * 2002-05-17 2005-02-10 Dillard David H. One-way valve devices for anchored implantation in a lung
US20050066974A1 (en) * 2002-05-28 2005-03-31 Antony Fields Modification of lung region flow dynamics using flow control devices implanted in bronchial wall channels
US20040039250A1 (en) * 2002-05-28 2004-02-26 David Tholfsen Guidewire delivery of implantable bronchial isolation devices in accordance with lung treatment
US20090036818A1 (en) * 2002-05-29 2009-02-05 University Of Saskatchewan Shunt and Method Treatment of Glaucoma
US7947008B2 (en) 2002-05-29 2011-05-24 University Of Saskatchewan Shunt and method treatment of glaucoma
US20050273033A1 (en) * 2002-05-29 2005-12-08 Grahn Bruce H Shunt and method treatment of glaucoma
US20040010209A1 (en) * 2002-07-15 2004-01-15 Spiration, Inc. Device and method for measuring the diameter of an air passageway
US20060076023A1 (en) * 2002-07-26 2006-04-13 Emphasys Medical, Inc., A Delaware Corporation Bronchial flow control devices and methods of use
US7488303B1 (en) 2002-09-21 2009-02-10 Glaukos Corporation Ocular implant with anchor and multiple openings
US8007459B2 (en) 2002-09-21 2011-08-30 Glaukos Corporation Ocular implant with anchoring mechanism and multiple outlets
US20040059263A1 (en) * 2002-09-24 2004-03-25 Spiration, Inc. Device and method for measuring the diameter of an air passageway
US7476203B2 (en) 2002-09-24 2009-01-13 Spiration, Inc. Device and method for measuring the diameter of an air passageway
US20060155217A1 (en) * 2002-09-24 2006-07-13 Devore Lauri J Device and method for measuring the diameter of an air passageway
US7717115B2 (en) 2002-11-27 2010-05-18 Pulmonx Corporation Delivery methods and devices for implantable bronchial isolation devices
US7814912B2 (en) 2002-11-27 2010-10-19 Pulmonx Corporation Delivery methods and devices for implantable bronchial isolation devices
US20060004305A1 (en) * 2002-11-27 2006-01-05 George Robert M Delivery methods and devices for implantable bronchial isolation devices
US20040148035A1 (en) * 2002-11-27 2004-07-29 Michael Barrett Delivery methods and devices for implantable bronchial isolation devices
US20110092767A1 (en) * 2002-11-27 2011-04-21 Pulmonx Corporation Delivery methods and devices for implantable bronchial isolation devices
WO2004062469A3 (en) * 2003-01-13 2005-05-12 Clarity Corp Sinus valved glaucoma shunt
WO2004062469A2 (en) * 2003-01-13 2004-07-29 Clarity Corporation Sinus valved glaucoma shunt
US20040254517A1 (en) * 2003-02-18 2004-12-16 Hugo Quiroz-Mercado Methods and devices for draining fluids and lowering intraocular pressure
EP1596902A2 (en) * 2003-02-18 2005-11-23 Hampar Karageozian Methods and devices for draining fluids and lowering intraocular pressure
US7354416B2 (en) * 2003-02-18 2008-04-08 Hugo Quiroz-Mercado Methods and devices for draining fluids and lowering intraocular pressure
EP1596902A4 (en) * 2003-02-18 2008-12-17 Hampar Karageozian Methods and devices for draining fluids and lowering intraocular pressure
JP2006517848A (en) * 2003-02-18 2006-08-03 カラジョージアン、ハンパー Method and apparatus for draining fluid and reducing intraocular pressure
US20090227933A1 (en) * 2003-02-18 2009-09-10 S.K. Pharmaceuticals Optic nerve implants
US8012115B2 (en) 2003-02-18 2011-09-06 S.K. Pharmaceuticals, Inc. Optic nerve implants
US9138345B2 (en) 2003-02-18 2015-09-22 S. K. Pharmaceuticals, Inc. Optic nerve implants
AU2004213006B2 (en) * 2003-02-18 2010-11-04 Hampar Karageozian Methods and devices for draining fluids and lowering intraocular pressure
US20040210248A1 (en) * 2003-03-12 2004-10-21 Spiration, Inc. Apparatus, method and assembly for delivery of intra-bronchial devices
US8679074B2 (en) 2003-03-18 2014-03-25 Angiodynamics, Inc. Pressure responsive slit valve assembly for a plurality of fluids and uses thereof
US20060249164A1 (en) * 2003-04-08 2006-11-09 Springmeyer Steven C Bronchoscopic lung volume reduction method
US8079368B2 (en) 2003-04-08 2011-12-20 Spiration, Inc. Bronchoscopic lung volume reduction method
US7100616B2 (en) 2003-04-08 2006-09-05 Spiration, Inc. Bronchoscopic lung volume reduction method
US8667973B2 (en) 2003-04-08 2014-03-11 Spiration, Inc. Bronchoscopic lung volume reduction method
US20040200484A1 (en) * 2003-04-08 2004-10-14 Springmeyer Steven C. Bronchoscopic lung volume reduction method
US20100256714A1 (en) * 2003-04-08 2010-10-07 Springmeyer Steven C Bronchoscopic lung volume reduction method
US9844462B2 (en) 2003-05-05 2017-12-19 Novartis Ag Internal shunt and method for treating glaucoma
US8444588B2 (en) 2003-05-05 2013-05-21 Transcend Medical, Inc. Internal shunt and method for treating glaucoma
US8945038B2 (en) 2003-05-05 2015-02-03 Transcend Medical, Inc. Internal shunt and method for treating glaucoma
US20070149915A1 (en) * 2003-05-05 2007-06-28 Judith Yablonski Internal shunt and method for treating glaucoma
US20040243393A1 (en) * 2003-05-29 2004-12-02 Microsoft Corporation Semantic object synchronous understanding implemented with speech application language tags
US10500329B2 (en) 2003-06-27 2019-12-10 Angiodynamics, Inc. Pressure actuated valve with improved biasing member
US8529523B2 (en) 2003-06-27 2013-09-10 Navilyst Medical, Inc. Pressure actuated valve with improved biasing member
US11628243B2 (en) 2003-06-27 2023-04-18 Angiodynamics, Inc. Pressure actuated valve with improved biasing member
US20050027261A1 (en) * 2003-07-30 2005-02-03 Karla Weaver Pressure actuated valve with improved slit configuration
US7951121B2 (en) * 2003-07-30 2011-05-31 Navilyst Medical, Inc. Pressure actuated valve with improved slit configuration
WO2005016418A1 (en) * 2003-08-05 2005-02-24 Glaukos Corporation Devices and methods for glaucoma treatment
US20090182369A1 (en) * 2003-08-08 2009-07-16 Spiration, Inc. Bronchoscopic repair of air leaks in a lung
US7887585B2 (en) 2003-08-08 2011-02-15 Spiration, Inc. Bronchoscopic repair of air leaks in a lung
US7533671B2 (en) 2003-08-08 2009-05-19 Spiration, Inc. Bronchoscopic repair of air leaks in a lung
US20110208228A1 (en) * 2003-08-08 2011-08-25 Spiration, Inc. Bronchoscopic repair of air leaks in a lung
US8974527B2 (en) 2003-08-08 2015-03-10 Spiration, Inc. Bronchoscopic repair of air leaks in a lung
US9622752B2 (en) 2003-08-08 2017-04-18 Spiration, Inc. Bronchoscopic repair of air leaks in a lung
US20050137714A1 (en) * 2003-08-08 2005-06-23 Gonzalez Hugo X. Bronchoscopic repair of air leaks in a lung
US8444690B2 (en) 2003-08-08 2013-05-21 Spiration, Inc. Bronchoscopic repair of air leaks in a lung
US8540685B2 (en) 2003-08-29 2013-09-24 Navilyst Medical, Inc. Valved catheters including high flow rate catheters
US8808220B2 (en) 2003-11-14 2014-08-19 Transcend Medical, Inc. Ocular pressure regulation
US7850638B2 (en) 2003-11-14 2010-12-14 Transcend Medical, Inc. Ocular pressure regulation
US20110087149A1 (en) * 2003-11-14 2011-04-14 Minas Theodore Coroneo Ocular pressure regulation
US9351873B2 (en) 2003-11-14 2016-05-31 Transcend Medical, Inc. Ocular pressure regulation
US20050107734A1 (en) * 2003-11-14 2005-05-19 Coroneo Minas T. Ocular pressure regulation
WO2005046782A1 (en) * 2003-11-14 2005-05-26 Minas Theodore Coroneo Ocular pressure regulation
US7291125B2 (en) 2003-11-14 2007-11-06 Transcend Medical, Inc. Ocular pressure regulation
US20070088242A1 (en) * 2003-11-14 2007-04-19 Coroneo Minas T Ocular pressure regulation
US20070106236A1 (en) * 2003-11-14 2007-05-10 Coroneo Minas T Ocular Pressure Regulation
US8128588B2 (en) * 2003-11-14 2012-03-06 Transcend Medical, Inc. Ocular pressure regulation
US10226380B2 (en) 2003-11-14 2019-03-12 Novartis Ag Ocular pressure regulation
US20110087151A1 (en) * 2003-11-14 2011-04-14 Minas Theodore Coroneo Ocular pressure regulation
AU2006202860B2 (en) * 2003-11-14 2010-11-04 Alcon Inc. Ocular pressure regulation
US8486000B2 (en) * 2003-11-14 2013-07-16 Transcend Medical, Inc. Ocular pressure regulation
AU2004288609B2 (en) * 2003-11-14 2010-10-28 Alcon Inc. Ocular pressure regulation
US20070106235A1 (en) * 2003-11-14 2007-05-10 Coroneo Minas T Ocular Pressure Regulation
US7815592B2 (en) 2003-11-14 2010-10-19 Transcend Medical, Inc. Ocular pressure regulation
US8728021B2 (en) 2003-11-14 2014-05-20 Transcend Medical, Inc. Ocular pressure regulation
US8758289B2 (en) 2003-11-14 2014-06-24 Transcend Medical, Inc. Ocular pressure regulation
US8771218B2 (en) 2003-11-14 2014-07-08 Transcend Medical, Inc. Ocular pressure regulation
US20050178389A1 (en) * 2004-01-27 2005-08-18 Shaw David P. Disease indications for selective endobronchial lung region isolation
US20090255537A1 (en) * 2004-01-27 2009-10-15 Pulmonx Disease indications for selective endobronchial lung region isolation
US8187234B2 (en) 2004-01-29 2012-05-29 Navilyst Medical, Inc. Pressure activated safety valve with anti-adherent coating
US10130750B2 (en) 2004-01-29 2018-11-20 Angiodynamics, Inc. Pressure activated valve with high flow slit
US20050171510A1 (en) * 2004-01-29 2005-08-04 Dicarlo Paul Pressure actuated safety valve with spiral flow membrane
US9933079B2 (en) 2004-01-29 2018-04-03 Angiodynamics, Inc. Stacked membrane for pressure actuated valve
US8454574B2 (en) 2004-01-29 2013-06-04 Navilyst Medical, Inc. Pressure activated safety valve with grooved membrane
US20050171489A1 (en) * 2004-01-29 2005-08-04 Karla Weaver Pressure activated safety valve with anti-adherent coating
US20050171490A1 (en) * 2004-01-29 2005-08-04 Karla Weaver Stacked membrane for pressure actuated valve
US8377011B2 (en) 2004-01-29 2013-02-19 Angiodynamics, Inc. Pressure activated valve with high flow slit
US20050250788A1 (en) * 2004-01-30 2005-11-10 Hosheng Tu Aqueous outflow enhancement with vasodilated aqueous cavity
US20050184004A1 (en) * 2004-02-24 2005-08-25 Rodgers M. S. Glaucoma implant having MEMS filter module
US20070199877A1 (en) * 2004-02-24 2007-08-30 Rodgers M S Mems filter module
US20060036207A1 (en) * 2004-02-24 2006-02-16 Koonmen James P System and method for treating glaucoma
US7384550B2 (en) 2004-02-24 2008-06-10 Becton, Dickinson And Company Glaucoma implant having MEMS filter module
US20050184003A1 (en) * 2004-02-24 2005-08-25 Rodgers M. S. MEMS filter module
US7226540B2 (en) 2004-02-24 2007-06-05 Becton, Dickinson And Company MEMS filter module
US20050196344A1 (en) * 2004-02-27 2005-09-08 Mccutcheon John Methods and devices for blocking flow through collateral pathways in the lung
US8206684B2 (en) 2004-02-27 2012-06-26 Pulmonx Corporation Methods and devices for blocking flow through collateral pathways in the lung
US20050197613A1 (en) * 2004-03-02 2005-09-08 Sniegowski Jeffry J. Implant having MEMS flow module with movable, flow-controlling baffle
US20050197653A1 (en) * 2004-03-02 2005-09-08 Sniegowski Jeffry J. Filter assembly with microfabricated filter element
US7364564B2 (en) 2004-03-02 2008-04-29 Becton, Dickinson And Company Implant having MEMS flow module with movable, flow-controlling baffle
US20050194303A1 (en) * 2004-03-02 2005-09-08 Sniegowski Jeffry J. MEMS flow module with filtration and pressure regulation capabilities
US20060020347A1 (en) * 2004-03-08 2006-01-26 Michael Barrett Implanted bronchial isolation devices and methods
WO2005122980A1 (en) * 2004-06-10 2005-12-29 James Savage Apparatus and method for non-pharmacological treatment of glaucoma and lowering intraocular pressure
US20050283108A1 (en) * 2004-06-10 2005-12-22 Savage James A Apparatus and method for non-pharmacological treatment of glaucoma and lowering intraocular pressure
US7862531B2 (en) 2004-06-25 2011-01-04 Optonol Ltd. Flow regulating implants
US20080077071A1 (en) * 2004-06-25 2008-03-27 Optonol Ltd. Flow Regulating Implants
US8034016B2 (en) 2004-06-25 2011-10-11 Optonol, Ltd. Flow regulating implants and methods of implanting
US20050288617A1 (en) * 2004-06-25 2005-12-29 Ira Yaron Flow regulating implants
US20060030863A1 (en) * 2004-07-21 2006-02-09 Fields Antony J Implanted bronchial isolation device delivery devices and methods
US20140034607A1 (en) * 2004-08-17 2014-02-06 Ellis Fan-chuin Meng Implantable intraocular pressure drain
US8246569B1 (en) * 2004-08-17 2012-08-21 California Institute Of Technology Implantable intraocular pressure drain
US9180050B2 (en) * 2004-08-17 2015-11-10 California Institute Of Technology Implantable intraocular pressure drain
US8585630B2 (en) * 2004-08-17 2013-11-19 California Institute Of Technology Implantable intraocular pressure drain
US11083556B2 (en) 2004-11-19 2021-08-10 Pulmonx Corporation Implant loading device and system
US9872755B2 (en) 2004-11-19 2018-01-23 Pulmonx Corporation Implant loading device and system
US7771472B2 (en) 2004-11-19 2010-08-10 Pulmonx Corporation Bronchial flow control devices and methods of use
US20060107956A1 (en) * 2004-11-19 2006-05-25 Hendricksen Michael J Bronchial flow control devices and methods of use
US9211181B2 (en) 2004-11-19 2015-12-15 Pulmonx Corporation Implant loading device and system
US20110010910A1 (en) * 2004-11-19 2011-01-20 Pulmonx Corporation Bronchial flow control devices and methods of use
US8388682B2 (en) 2004-11-19 2013-03-05 Pulmonx Corporation Bronchial flow control devices and methods of use
US20060173399A1 (en) * 2005-02-01 2006-08-03 Rodgers M S MEMS flow module with pivoting-type baffle
US20060184139A1 (en) * 2005-02-11 2006-08-17 Quigley Karla W Pressure activated safety valve with improved flow characteristics and durability
US8328768B2 (en) 2005-02-11 2012-12-11 Angiodynamics, Inc Pressure activated safety valve with improved flow characteristics and durability
US8876791B2 (en) 2005-02-25 2014-11-04 Pulmonx Corporation Collateral pathway treatment using agent entrained by aspiration flow current
US20060206049A1 (en) * 2005-03-14 2006-09-14 Rodgers M S MEMS flow module with piston-type pressure regulating structure
US20080195044A1 (en) * 2005-03-23 2008-08-14 Akira Nishimura Ophthalmic Cannula
US20060219627A1 (en) * 2005-03-31 2006-10-05 Rodgers M S MEMS filter module with concentric filtering walls
US7544176B2 (en) 2005-06-21 2009-06-09 Becton, Dickinson And Company Glaucoma implant having MEMS flow module with flexing diaphragm for pressure regulation
US20070004998A1 (en) * 2005-06-21 2007-01-04 Rodgers M S Glaucoma implant having MEMS flow module with flexing diaphragm for pressure regulation
US20070156079A1 (en) * 2005-09-16 2007-07-05 Bg Implant, Inc. Glaucoma Treatment Devices and Methods
US20070106200A1 (en) * 2005-11-08 2007-05-10 Brian Levy Intraocular shunt device and method
US8721656B2 (en) 2006-01-17 2014-05-13 Transcend Medical, Inc. Glaucoma treatment device
US20070233037A1 (en) * 2006-01-17 2007-10-04 Gifford Hanson S Iii Drug Delivery Treatment Device
US8801649B2 (en) 2006-01-17 2014-08-12 Transcend Medical, Inc. Glaucoma treatment device
US9398977B2 (en) 2006-01-17 2016-07-26 Transcend Medical, Inc. Glaucoma treatment device
US20110028883A1 (en) * 2006-01-17 2011-02-03 Juan Jr Eugene De Glaucoma treatment device
US8734378B2 (en) 2006-01-17 2014-05-27 Transcend Medical, Inc. Glaucoma treatment device
US20100010416A1 (en) * 2006-01-17 2010-01-14 Juan Jr Eugene De Glaucoma treatment device
US9789000B2 (en) 2006-01-17 2017-10-17 Novartis Ag Glaucoma treatment device
US9084662B2 (en) 2006-01-17 2015-07-21 Transcend Medical, Inc. Drug delivery treatment device
US20070191863A1 (en) * 2006-01-17 2007-08-16 De Juan Eugene Jr Glaucoma Treatment Device
US10905590B2 (en) 2006-01-17 2021-02-02 Alcon Inc. Glaucoma treatment device
US9421130B2 (en) 2006-01-17 2016-08-23 Novartis Ag. Glaucoma treatment device
US9668917B2 (en) 2006-01-17 2017-06-06 Novartis Ag Drug delivery treatment device
US11786402B2 (en) 2006-01-17 2023-10-17 Alcon Inc. Glaucoma treatment device
US8814819B2 (en) 2006-01-17 2014-08-26 Transcend Medical, Inc. Glaucoma treatment device
US8585660B2 (en) 2006-01-25 2013-11-19 Navilyst Medical, Inc. Valved catheter with power injection bypass
US20070173777A1 (en) * 2006-01-25 2007-07-26 Nathan Murphy Valved catheter with power injection bypass
US8454708B2 (en) 2006-03-31 2013-06-04 Spiration, Inc. Articulable anchor
US9198669B2 (en) 2006-03-31 2015-12-01 Spiration, Inc. Articulable anchor
US20100262071A1 (en) * 2006-03-31 2010-10-14 James Kutsko Articulable anchor
US8647392B2 (en) 2006-03-31 2014-02-11 Spiration, Inc. Articulable anchor
US20070235846A1 (en) * 2006-04-01 2007-10-11 Stats Chippac Ltd. Integrated circuit package system with net spacer
US20070293807A1 (en) * 2006-05-01 2007-12-20 Lynch Mary G Dual drainage pathway shunt device and method for treating glaucoma
US20100234791A1 (en) * 2006-05-01 2010-09-16 Glaukos Corporation Dual drainage pathway shunt device
US20100121248A1 (en) * 2006-06-30 2010-05-13 Aquesys, Inc. Apparatus for reducing pressure in an organ
US20080108933A1 (en) * 2006-06-30 2008-05-08 Dao-Yi Yu Methods, Systems and Apparatus for Relieving Pressure in an Organ
US20110118745A1 (en) * 2006-06-30 2011-05-19 Aquesys, Inc. Methods, systems and apparatus for relieving pressure in an organ
US9636254B2 (en) 2006-06-30 2017-05-02 Aquesys, Inc. Systems for reducing pressure in an organ
US20100119696A1 (en) * 2006-06-30 2010-05-13 Aquesys, Inc. Manufacture of an organ implant
US20100100104A1 (en) * 2006-06-30 2010-04-22 Aquesys, Inc. Systems for reducing pressure in an organ
US10085884B2 (en) 2006-06-30 2018-10-02 Aquesys, Inc. Intraocular devices
US20100121249A1 (en) * 2006-06-30 2010-05-13 Aquesys, Inc. Methods for reducing pressure in an organ
US20080072914A1 (en) * 2006-08-25 2008-03-27 Hendricksen Michael J Bronchial Isolation Devices for Placement in Short Lumens
US20080228127A1 (en) * 2006-11-10 2008-09-18 Glaukos Corporation Uveoscleral shunt and methods for implanting same
US10828195B2 (en) 2006-11-10 2020-11-10 Glaukos Corporation Uveoscleral shunt and methods for implanting same
US9962290B2 (en) 2006-11-10 2018-05-08 Glaukos Corporation Uveoscleral shunt and methods for implanting same
US8506515B2 (en) * 2006-11-10 2013-08-13 Glaukos Corporation Uveoscleral shunt and methods for implanting same
US20080172204A1 (en) * 2007-01-15 2008-07-17 Fujitsu Limited Step counter and method of counting steps
US20080277332A1 (en) * 2007-05-11 2008-11-13 Becton, Dickinson And Company Micromachined membrane filter device for a glaucoma implant and method for making the same
EP2164557B1 (en) * 2007-06-29 2018-05-30 Applied Medical Technology, Inc. Molded an undivided medical penetrating device
US20120041270A1 (en) * 2007-06-29 2012-02-16 Applied Medical Technology, Inc. Molded and undivided medical penetrating device
US8382664B2 (en) * 2007-06-29 2013-02-26 Applied Medical Technology, Inc. Molded and undivided medical penetrating device
US8672870B2 (en) 2007-07-17 2014-03-18 Transcend Medical, Inc. Ocular implant with hydrogel expansion capabilities
US9585789B2 (en) 2007-07-17 2017-03-07 Novartis Ag Ocular implant with hydrogel expansion capabilities
US9039650B2 (en) 2007-09-24 2015-05-26 Ivantis, Inc. Ocular implants with asymmetric flexibility
US20090082860A1 (en) * 2007-09-24 2009-03-26 Schieber Andrew T Ocular Implants with Asymmetric Flexibility
US8734377B2 (en) 2007-09-24 2014-05-27 Ivantis, Inc. Ocular implants with asymmetric flexibility
US9610196B2 (en) 2007-09-24 2017-04-04 Ivantis, Inc. Ocular implants with asymmetric flexibility
US8282592B2 (en) 2007-09-24 2012-10-09 Ivantis, Inc. Glaucoma treatment method
US8961447B2 (en) 2007-09-24 2015-02-24 Ivantis, Inc. Glaucoma treatment method
US11744734B2 (en) 2007-09-24 2023-09-05 Alcon Inc. Method of implanting an ocular implant
US20100222733A1 (en) * 2007-09-24 2010-09-02 Schieber Andrew T Glaucoma Treatment Method
US8372026B2 (en) 2007-09-24 2013-02-12 Ivantis, Inc. Ocular implant architectures
US9402767B2 (en) 2007-09-24 2016-08-02 Ivantis, Inc. Ocular implant architectures
US8414518B2 (en) 2007-09-24 2013-04-09 Ivantis, Inc. Glaucoma treatment method
US20090292262A1 (en) * 2007-10-12 2009-11-26 Martin Neal Adams Valve loader method, system, and apparatus
US20090099530A1 (en) * 2007-10-12 2009-04-16 Martin Neal Adams Valve loader method, system, and apparatus
US8043301B2 (en) 2007-10-12 2011-10-25 Spiration, Inc. Valve loader method, system, and apparatus
US8136230B2 (en) 2007-10-12 2012-03-20 Spiration, Inc. Valve loader method, system, and apparatus
US9326873B2 (en) 2007-10-12 2016-05-03 Spiration, Inc. Valve loader method, system, and apparatus
US8512404B2 (en) 2007-11-20 2013-08-20 Ivantis, Inc. Ocular implant delivery system and method
US8808222B2 (en) 2007-11-20 2014-08-19 Ivantis, Inc. Methods and apparatus for delivering ocular implants into the eye
US9351874B2 (en) 2007-11-20 2016-05-31 Ivantis, Inc. Methods and apparatus for delivering ocular implants into the eye
US20090132040A1 (en) * 2007-11-20 2009-05-21 Ivantis, Inc. Ocular Implant Delivery System and Method
US9226852B2 (en) 2007-11-20 2016-01-05 Ivantis, Inc. Methods and apparatus for delivering ocular implants into the eye
US8551166B2 (en) 2007-11-20 2013-10-08 Ivantis, Inc. Methods and apparatus for delivering ocular implants into the eye
US9050169B2 (en) 2007-11-20 2015-06-09 Ivantis, Inc. Methods and apparatus for delivering ocular implants into the eye
US20150157836A1 (en) * 2008-01-28 2015-06-11 Peter Mats Forsell Implantable drainage device
US9694165B2 (en) * 2008-01-28 2017-07-04 Peter Mats Forsell Implantable drainage device
US20090204053A1 (en) * 2008-02-11 2009-08-13 Optonol Ltd. Devices and methods for opening fluid passageways
US8109896B2 (en) 2008-02-11 2012-02-07 Optonol Ltd. Devices and methods for opening fluid passageways
US9066783B2 (en) 2008-03-05 2015-06-30 Ivantis, Inc. Methods and apparatus for treating glaucoma
US11504275B2 (en) 2008-03-05 2022-11-22 Alcon Inc. Methods and apparatus for treating glaucoma
US10537474B2 (en) 2008-03-05 2020-01-21 Ivantis, Inc. Methods and apparatus for treating glaucoma
US9693902B2 (en) 2008-03-05 2017-07-04 Ivantis, Inc. Methods and apparatus for treating glaucoma
US20090227934A1 (en) * 2008-03-05 2009-09-10 Euteneuer Charles L Methods and Apparatus for Treating Glaucoma
US8267882B2 (en) 2008-03-05 2012-09-18 Ivantis, Inc. Methods and apparatus for treating glaucoma
US8529494B2 (en) 2008-03-05 2013-09-10 Ivantis, Inc. Methods and apparatus for treating glaucoma
US8257321B2 (en) 2008-05-21 2012-09-04 Navilyst Medical, Inc. Pressure activated valve for high flow rate and pressure venous access applications
US20090292252A1 (en) * 2008-05-21 2009-11-26 Raymond Lareau Pressure Activated Valve for High Flow Rate and Pressure Venous Access Applications
US9447892B2 (en) 2008-05-21 2016-09-20 Angiodynamics, Inc. Pressure activated valve for high flow rate and pressure venous access applications
US11679248B2 (en) 2008-05-21 2023-06-20 Angiodynamics, Inc. Pressure activated valve for high flow rate and pressure venous access applications
US20100137981A1 (en) * 2008-06-25 2010-06-03 Silvestrini Thomas A Ocular implant with shape change capabilities
US10016301B2 (en) 2008-06-25 2018-07-10 Novartis Ag Ocular implant with shape change capabilities
US8617139B2 (en) 2008-06-25 2013-12-31 Transcend Medical, Inc. Ocular implant with shape change capabilities
US8353856B2 (en) 2008-11-05 2013-01-15 Abbott Medical Optics Inc. Glaucoma drainage shunts and methods of use
US8920357B2 (en) 2008-11-05 2014-12-30 Abbott Medical Optics Inc. Glaucoma drainage shunts and methods of use
US20100114006A1 (en) * 2008-11-05 2010-05-06 Advanced Medical Optics, Inc. Glaucoma drainage shunts and methods of use
US9468558B2 (en) 2008-11-05 2016-10-18 Abbott Medical Optics Inc. Glaucoma drainage shunts and methods of use
US10492948B2 (en) 2008-11-05 2019-12-03 Johnson & Johnson Surgical Vision, Inc. Glaucoma drainage shunts and methods of use
US20100174272A1 (en) * 2009-01-02 2010-07-08 Weiner Alan L In-situ refillable ophthalmic implant
US20100274258A1 (en) * 2009-01-28 2010-10-28 Silvestrini Thomas A Ocular implant with stiffness qualities, methods of implantation and system
US8337470B2 (en) 2009-01-28 2012-12-25 Angiodynamics, Inc. Three-way valve for power injection in vascular access devices
US10531983B2 (en) 2009-01-28 2020-01-14 Novartis Ag Ocular implant with stiffness qualities, methods of implantation and system
US8574294B2 (en) 2009-01-28 2013-11-05 Transcend Medical, Inc. Ocular implant with stiffness qualities, methods of implantation and system
US8377122B2 (en) 2009-01-28 2013-02-19 Transcend Medical, Inc. Ocular implant with stiffness qualities, methods of implantation and system
US8167939B2 (en) 2009-01-28 2012-05-01 Transcend Medical, Inc. Ocular implant with stiffness qualities, methods of implantation and system
US20110087148A1 (en) * 2009-01-28 2011-04-14 Silvestrini Thomas A Ocular implant with stiffness qualities, methods of implantation and system
US20100191192A1 (en) * 2009-01-28 2010-07-29 Jayanthi Prasad Three-way Valve for Power Injection in Vascular Access Devices
US8172899B2 (en) 2009-01-28 2012-05-08 Transcend Medical, Inc. Ocular implant with stiffness qualities, methods of implantation and system
US20110028983A1 (en) * 2009-01-28 2011-02-03 Silvestrini Thomas A Ocular implant with stiffness qualities, methods of implantation and system
US9763828B2 (en) 2009-01-28 2017-09-19 Novartis Ag Ocular implant with stiffness qualities, methods of implantation and system
US11344448B2 (en) 2009-01-28 2022-05-31 Alcon Inc. Ocular implant with stiffness qualities, methods of implantation and system
US8262726B2 (en) 2009-01-28 2012-09-11 Transcend Medical, Inc. Ocular implant with stiffness qualities, methods of implantation and system
US11839571B2 (en) 2009-01-28 2023-12-12 Alcon Inc. Ocular implant with stiffness qualities, methods of implantation and system
US8523821B2 (en) 2009-01-29 2013-09-03 Navilyst Medical, Inc Power injection valve
US20110282456A1 (en) * 2009-02-05 2011-11-17 Newvert Ltd. Implantable device for sealing a spinal annular fissure tear and method for deploying the same
US8702639B2 (en) 2009-03-26 2014-04-22 Abbott Medical Optics Inc. Glaucoma shunts with flow management and improved surgical performance
US20100249691A1 (en) * 2009-03-26 2010-09-30 Abbott Medical Optics Inc. Glaucoma shunts with flow management and improved surgical performance
WO2010126076A1 (en) * 2009-04-30 2010-11-04 マニー株式会社 Cannula for ophthalmic surgery and method of manufacturing same
US11596546B2 (en) 2009-07-09 2023-03-07 Alcon Inc. Ocular implants and methods for delivering ocular implants into the eye
US20110009874A1 (en) * 2009-07-09 2011-01-13 John Wardle Single Operator Device for Delivering an Ocular Implant
US20110009958A1 (en) * 2009-07-09 2011-01-13 John Wardle Ocular Implants and Methods for Delivering Ocular Implants Into the Eye
US9693899B2 (en) 2009-07-09 2017-07-04 Ivantis, Inc. Single operator device for delivering an ocular implant
US10492949B2 (en) 2009-07-09 2019-12-03 Ivantis, Inc. Single operator device for delivering an ocular implant
US8425449B2 (en) 2009-07-09 2013-04-23 Ivantis, Inc. Ocular implants and methods for delivering ocular implants into the eye
US9211213B2 (en) 2009-07-09 2015-12-15 Ivantis, Inc. Ocular implants and methods for delivering ocular implants into the eye
US10406025B2 (en) 2009-07-09 2019-09-10 Ivantis, Inc. Ocular implants and methods for delivering ocular implants into the eye
US11464675B2 (en) 2009-07-09 2022-10-11 Alcon Inc. Single operator device for delivering an ocular implant
US11918514B2 (en) 2009-07-09 2024-03-05 Alcon Inc. Single operator device for delivering an ocular implant
US8753320B2 (en) 2009-07-13 2014-06-17 Navilyst Medical, Inc. Method to secure an elastic component in a valve
US10874845B2 (en) 2009-07-13 2020-12-29 Angiodynamics, Inc. Method to secure an elastic component in a valve
US11612734B2 (en) 2009-07-13 2023-03-28 Angiodynamics, Inc. Method to secure an elastic component in a valve
US20110087093A1 (en) * 2009-10-09 2011-04-14 Navilyst Medical, Inc. Valve configurations for implantable medical devices
US9579234B2 (en) 2009-10-23 2017-02-28 Ivantis, Inc. Ocular implant system and method
US20110098809A1 (en) * 2009-10-23 2011-04-28 John Wardle Ocular Implant System and Method
US20110105990A1 (en) * 2009-11-04 2011-05-05 Silvestrini Thomas A Zonal drug delivery device and method
US20110118612A1 (en) * 2009-11-18 2011-05-19 Navilyst Medical, Inc. Valved Catheter with Integrated Pressure Measurement Capabilities
US8343106B2 (en) 2009-12-23 2013-01-01 Alcon Research, Ltd. Ophthalmic valved trocar vent
US20110152774A1 (en) * 2009-12-23 2011-06-23 Jose Luis Lopez Ophthalmic valved trocar cannula
US20110238075A1 (en) * 2009-12-23 2011-09-29 Luke Clauson Drug delivery devices and methods
US8679064B2 (en) 2009-12-23 2014-03-25 Alcon Research, Ltd. Ophthalmic valved trocar cannula
US9089392B2 (en) 2009-12-23 2015-07-28 Transcend Medical, Inc. Drug delivery devices and methods
US20110152775A1 (en) * 2009-12-23 2011-06-23 Jose Luis Lopez Ophthalmic valved trocar vent
US8529492B2 (en) 2009-12-23 2013-09-10 Trascend Medical, Inc. Drug delivery devices and methods
US8277418B2 (en) 2009-12-23 2012-10-02 Alcon Research, Ltd. Ophthalmic valved trocar cannula
US9549846B2 (en) 2009-12-23 2017-01-24 Novartis Ag Drug delivery devices and methods
US20130006164A1 (en) * 2010-03-26 2013-01-03 Optonol Ltd. Fluid drainage device, delivery device, and associated methods of use and manufacture
AU2011232403B2 (en) * 2010-03-26 2014-05-22 Alcon Inc. Fluid drainage device, delivery device, and associated methods of use and manufacture
US9173774B2 (en) * 2010-03-26 2015-11-03 Optonol Ltd. Fluid drainage device, delivery device, and associated methods of use and manufacture
US9510973B2 (en) 2010-06-23 2016-12-06 Ivantis, Inc. Ocular implants deployed in schlemm's canal of the eye
US20130116652A1 (en) * 2010-07-12 2013-05-09 Ramot At Tel-Aviv University Ltd. Catheter cannula with anchoring elements, catheter including thereof, and/or catheterization method using
US10080838B2 (en) * 2010-07-12 2018-09-25 Ramot At Tel-Aviv University Ltd. Catheter cannula with anchoring elements, catheter including thereof, and/or catheterization method using thereof
US9393153B2 (en) 2010-11-15 2016-07-19 Aquesys, Inc. Methods for intraocular shunt placement
US8663303B2 (en) 2010-11-15 2014-03-04 Aquesys, Inc. Methods for deploying an intraocular shunt from a deployment device and into an eye
US9693901B2 (en) 2010-11-15 2017-07-04 Aquesys, Inc. Shunt placement through the sclera
US8585629B2 (en) 2010-11-15 2013-11-19 Aquesys, Inc. Systems for deploying intraocular shunts
US8308701B2 (en) 2010-11-15 2012-11-13 Aquesys, Inc. Methods for deploying intraocular shunts
US8828070B2 (en) 2010-11-15 2014-09-09 Aquesys, Inc. Devices for deploying intraocular shunts
US9192516B2 (en) 2010-11-15 2015-11-24 Aquesys, Inc. Intraocular shunt placement
US9877866B2 (en) 2010-11-15 2018-01-30 Aquesys, Inc. Intraocular shunt placement
US9095411B2 (en) 2010-11-15 2015-08-04 Aquesys, Inc. Devices for deploying intraocular shunts
US9017276B2 (en) 2010-11-15 2015-04-28 Aquesys, Inc. Shunt placement through the sclera
US8974511B2 (en) 2010-11-15 2015-03-10 Aquesys, Inc. Methods for treating closed angle glaucoma
US8852137B2 (en) 2010-11-15 2014-10-07 Aquesys, Inc. Methods for implanting a soft gel shunt in the suprachoroidal space
US9283116B2 (en) 2010-11-15 2016-03-15 Aquesys, Inc. Intraocular shunt deployment device
US8801766B2 (en) 2010-11-15 2014-08-12 Aquesys, Inc. Devices for deploying intraocular shunts
US9980854B2 (en) 2010-11-15 2018-05-29 Aquesys, Inc. Shunt placement through the sclera
US8721702B2 (en) 2010-11-15 2014-05-13 Aquesys, Inc. Intraocular shunt deployment devices
US10842671B2 (en) 2010-11-15 2020-11-24 Aquesys, Inc. Intraocular shunt placement in the suprachoroidal space
US8758290B2 (en) 2010-11-15 2014-06-24 Aquesys, Inc. Devices and methods for implanting a shunt in the suprachoroidal space
US9326891B2 (en) 2010-11-15 2016-05-03 Aquesys, Inc. Methods for deploying intraocular shunts
US10004638B2 (en) 2010-11-15 2018-06-26 Aquesys, Inc. Intraocular shunt delivery
US8852256B2 (en) 2010-11-15 2014-10-07 Aquesys, Inc. Methods for intraocular shunt placement
US10307293B2 (en) 2010-11-15 2019-06-04 Aquesys, Inc. Methods for intraocular shunt placement
US10940040B2 (en) 2010-11-15 2021-03-09 Aquesys, Inc. Intraocular shunt placement
US8795241B2 (en) 2011-05-13 2014-08-05 Spiration, Inc. Deployment catheter
US10363168B2 (en) 2011-06-14 2019-07-30 Ivantis, Inc. Ocular implants for delivery into the eye
US9155655B2 (en) 2011-06-14 2015-10-13 Ivantis, Inc. Ocular implants for delivery into the eye
US8657776B2 (en) 2011-06-14 2014-02-25 Ivantis, Inc. Ocular implants for delivery into the eye
US11363951B2 (en) 2011-09-13 2022-06-21 Glaukos Corporation Intraocular physiological sensor
US10350048B2 (en) 2011-09-23 2019-07-16 Pulmonx Corporation Implant loading device and system
US9592154B2 (en) 2011-12-08 2017-03-14 Aquesys, Inc. Intraocular shunt manufacture
US8852136B2 (en) 2011-12-08 2014-10-07 Aquesys, Inc. Methods for placing a shunt into the intra-scleral space
US9095413B2 (en) 2011-12-08 2015-08-04 Aquesys, Inc. Intraocular shunt manufacture
US9271869B2 (en) 2011-12-08 2016-03-01 Aquesys, Inc. Intrascleral shunt placement
US9883969B2 (en) 2011-12-08 2018-02-06 Aquesys, Inc. Intrascleral shunt placement
US10080682B2 (en) 2011-12-08 2018-09-25 Aquesys, Inc. Intrascleral shunt placement
US8765210B2 (en) 2011-12-08 2014-07-01 Aquesys, Inc. Systems and methods for making gelatin shunts
US10314743B2 (en) 2011-12-08 2019-06-11 Aquesys, Inc. Intraocular shunt manufacture
US9113994B2 (en) 2011-12-08 2015-08-25 Aquesys, Inc. Intraocular shunt manufacture
US8663150B2 (en) 2011-12-19 2014-03-04 Ivantis, Inc. Delivering ocular implants into the eye
US9066750B2 (en) 2011-12-19 2015-06-30 Ivantis, Inc. Delivering ocular implants into the eye
US11135088B2 (en) 2011-12-19 2021-10-05 Ivantis Inc. Delivering ocular implants into the eye
US9931243B2 (en) 2011-12-19 2018-04-03 Ivantis, Inc. Delivering ocular implants into the eye
US11944573B2 (en) 2012-03-26 2024-04-02 Glaukos Corporation System and method for delivering multiple ocular implants
US11197780B2 (en) 2012-03-26 2021-12-14 Glaukos Corporation System and method for delivering multiple ocular implants
US9554940B2 (en) 2012-03-26 2017-01-31 Glaukos Corporation System and method for delivering multiple ocular implants
US10271989B2 (en) 2012-03-26 2019-04-30 Glaukos Corporation System and method for delivering multiple ocular implants
US11026836B2 (en) 2012-04-18 2021-06-08 Ivantis, Inc. Ocular implants for delivery into an anterior chamber of the eye
US9358156B2 (en) 2012-04-18 2016-06-07 Invantis, Inc. Ocular implants for delivery into an anterior chamber of the eye
US10085633B2 (en) 2012-04-19 2018-10-02 Novartis Ag Direct visualization system for glaucoma treatment
US10912676B2 (en) 2012-04-24 2021-02-09 Alcon Inc. Delivery system for ocular implant
US9241832B2 (en) 2012-04-24 2016-01-26 Transcend Medical, Inc. Delivery system for ocular implant
US9155656B2 (en) 2012-04-24 2015-10-13 Transcend Medical, Inc. Delivery system for ocular implant
US9907697B2 (en) 2012-04-24 2018-03-06 Novartis Ag Delivery system for ocular implant
US9526623B2 (en) 2012-05-30 2016-12-27 Newvert Ltd. Spinal disc annulus closure device
US9895524B2 (en) 2012-07-13 2018-02-20 Angiodynamics, Inc. Fluid bypass device for valved catheters
US9480598B2 (en) 2012-09-17 2016-11-01 Novartis Ag Expanding ocular implant devices and methods
US9763829B2 (en) 2012-11-14 2017-09-19 Novartis Ag Flow promoting ocular implant
US10617558B2 (en) 2012-11-28 2020-04-14 Ivantis, Inc. Apparatus for delivering ocular implants into an anterior chamber of the eye
US11712369B2 (en) 2012-11-28 2023-08-01 Alcon Inc. Apparatus for delivering ocular implants into an anterior chamber of the eye
US10195078B2 (en) 2013-02-19 2019-02-05 Aquesys, Inc. Adjustable intraocular flow regulation
US10195079B2 (en) 2013-02-19 2019-02-05 Aquesys, Inc. Adjustable intraocular implant
US10159600B2 (en) 2013-02-19 2018-12-25 Aquesys, Inc. Adjustable intraocular flow regulation
US9125723B2 (en) 2013-02-19 2015-09-08 Aquesys, Inc. Adjustable glaucoma implant
US10524959B2 (en) 2013-02-27 2020-01-07 Aquesys, Inc. Intraocular shunt implantation methods and devices
US9610195B2 (en) 2013-02-27 2017-04-04 Aquesys, Inc. Intraocular shunt implantation methods and devices
US9730638B2 (en) 2013-03-13 2017-08-15 Glaukos Corporation Intraocular physiological sensor
US10849558B2 (en) 2013-03-13 2020-12-01 Glaukos Corporation Intraocular physiological sensor
US10188551B2 (en) 2013-03-15 2019-01-29 Glaukos Corporation Systems and methods for delivering an ocular implant to the suprachoroidal space within an eye
US10517759B2 (en) 2013-03-15 2019-12-31 Glaukos Corporation Glaucoma stent and methods thereof for glaucoma treatment
US9592151B2 (en) 2013-03-15 2017-03-14 Glaukos Corporation Systems and methods for delivering an ocular implant to the suprachoroidal space within an eye
US11559430B2 (en) 2013-03-15 2023-01-24 Glaukos Corporation Glaucoma stent and methods thereof for glaucoma treatment
US9987163B2 (en) 2013-04-16 2018-06-05 Novartis Ag Device for dispensing intraocular substances
US9808373B2 (en) 2013-06-28 2017-11-07 Aquesys, Inc. Intraocular shunt implantation
US10369048B2 (en) 2013-06-28 2019-08-06 Aquesys, Inc. Intraocular shunt implantation
US11298264B2 (en) 2013-06-28 2022-04-12 Aquesys, Inc. Intraocular shunt implantation
US9693900B2 (en) 2013-08-06 2017-07-04 Manuel Humberto Gallardo Inzunza Intraocular pressure compensating and regulating valve
JP2015089490A (en) * 2013-11-07 2015-05-11 テルモ株式会社 Medical treatment instrument
US10653555B2 (en) 2013-11-14 2020-05-19 Aquesys, Inc. Intraocular shunt insertion techniques
US9585790B2 (en) 2013-11-14 2017-03-07 Aquesys, Inc. Intraocular shunt inserter
US11938059B2 (en) 2013-11-14 2024-03-26 Aquesys, Inc. Intraocular shunt insertion techniques
US10470928B2 (en) 2013-11-14 2019-11-12 Aquesys, Inc. Intraocular shunt inserter
US20160302965A1 (en) * 2013-12-06 2016-10-20 Forsight Vision4, Inc. Implantable therapeutic devices
US10959941B2 (en) 2014-05-29 2021-03-30 Glaukos Corporation Implants with controlled drug delivery features and methods of using same
US10709547B2 (en) 2014-07-14 2020-07-14 Ivantis, Inc. Ocular implant delivery system and method
US10369050B2 (en) 2014-08-29 2019-08-06 Camras Vision Inc. Device and method for reducing intraocular pressure
US10342702B2 (en) 2014-08-29 2019-07-09 Camras Vision Inc. Apparatus and method for reducing intraocular pressure
WO2016060538A1 (en) * 2014-10-17 2016-04-21 Manuel Humberto Gallardo Inzunza Valve for compensating and regulating intraocular pressure
EP3240510A4 (en) * 2014-12-31 2018-09-19 Microoptx Inc. Glaucoma treatment devices and methods
AU2015374033B2 (en) * 2014-12-31 2020-07-02 Microoptx Inc. Glaucoma treatment devices and methods
US10736778B2 (en) 2014-12-31 2020-08-11 Microoptx Inc. Glaucoma treatment devices and methods
JP2018501010A (en) * 2014-12-31 2018-01-18 マイクロオプティクス インコーポレイテッド Glaucoma treatment apparatus and method
CN107530189A (en) * 2014-12-31 2018-01-02 迈克罗欧普提克斯股份有限公司 Glaucoma treatment device and method
US9744076B2 (en) 2015-03-16 2017-08-29 Jeannette M. A. da Silva Curiel Method and apparatus for inserting an implant in the cornea of the eye
WO2016149425A1 (en) * 2015-03-16 2016-09-22 Da Silva Curiel Jeannette M A Method and apparatus for inserting an implant in the cornea of the eye
US10463537B2 (en) 2015-06-03 2019-11-05 Aquesys Inc. Ab externo intraocular shunt placement
US10470927B2 (en) 2015-06-03 2019-11-12 Aquesys, Inc. AB externo intraocular shunt placement
US11612517B2 (en) 2015-06-03 2023-03-28 Aquesys, Inc. Ab externo intraocular shunt placement
US11337856B2 (en) 2015-06-26 2022-05-24 Innfocus, Inc. Glaucoma device delivery system and trans-conjunctival method of delivery
US11197779B2 (en) 2015-08-14 2021-12-14 Ivantis, Inc. Ocular implant with pressure sensor and delivery system
US11925578B2 (en) 2015-09-02 2024-03-12 Glaukos Corporation Drug delivery implants with bi-directional delivery capacity
US10524958B2 (en) 2015-09-30 2020-01-07 Alievio, Inc. Method and apparatus for reducing intraocular pressure
US10980667B2 (en) 2015-09-30 2021-04-20 Microoptx Inc. Eye treatment devices and methods
US11938058B2 (en) 2015-12-15 2024-03-26 Alcon Inc. Ocular implant and delivery system
US10667947B2 (en) 2016-06-02 2020-06-02 Aquesys, Inc. Intraocular drug delivery
US10610678B2 (en) 2016-08-11 2020-04-07 Angiodynamics, Inc. Bi-directional, pressure-actuated medical valve with improved fluid flow control and method of using such
US11116625B2 (en) 2017-09-28 2021-09-14 Glaukos Corporation Apparatus and method for controlling placement of intraocular implants
CN111295164A (en) * 2017-10-23 2020-06-16 株式会社都可耐 Implant and implant system
JP2019076304A (en) * 2017-10-23 2019-05-23 株式会社ドックスネット Implant and implant system
TWI722329B (en) * 2017-10-23 2021-03-21 日商Doxnet股份有限公司 Implant and implant system
CN111295164B (en) * 2017-10-23 2022-07-01 株式会社都可耐 Implant and implant system
WO2019082448A1 (en) * 2017-10-23 2019-05-02 株式会社ドックスネット Implant and implant system
US11246753B2 (en) 2017-11-08 2022-02-15 Aquesys, Inc. Manually adjustable intraocular flow regulation
US11833080B2 (en) 2018-03-07 2023-12-05 Carl Zeiss Meditec Ag Planning device and method for generating control data for an ophthalmological laser therapy device for structures bridging the cornea in a pressure-reducing manner
WO2019170752A1 (en) 2018-03-07 2019-09-12 Carl Zeiss Meditec Ag Shunt implant
WO2019170669A1 (en) 2018-03-07 2019-09-12 Carl Zeiss Meditec Ag Planning device and method for generating control data for an ophthalmological laser therapy device for structures bridging the cornea in a pressure-reducing manner
DE102018203356A1 (en) 2018-03-07 2019-09-12 Carl Zeiss Meditec Ag Planning device and method for generating control data for an ophthalmic laser therapy device for structures for pressure-reducing bridging of the cornea
DE102018203424A1 (en) 2018-03-07 2019-09-12 Carl Zeiss Meditec Ag Shunt implant
US11135089B2 (en) 2018-03-09 2021-10-05 Aquesys, Inc. Intraocular shunt inserter
US10952898B2 (en) 2018-03-09 2021-03-23 Aquesys, Inc. Intraocular shunt inserter
US11446179B2 (en) 2018-04-03 2022-09-20 Jack Chu Ocular device and method for glaucoma treatment
WO2019195419A1 (en) 2018-04-03 2019-10-10 Jack Chu A new ocular device and method for glaucoma treatment
CN109363726A (en) * 2018-04-11 2019-02-22 中山大学中山眼科中心 The acquisition device of liquid sample with valve
WO2022049140A1 (en) 2020-09-04 2022-03-10 Carl Zeiss Meditec Ag Stent implant for treating glaucoma by means of intraocular fluid drainage from the anterior chamber
DE102020211175A1 (en) 2020-09-04 2022-03-10 Carl Zeiss Meditec Ag Stent implant for glaucoma treatment by drainage of aqueous humor from the anterior chamber
WO2022058606A1 (en) 2020-09-21 2022-03-24 Carl Zeiss Meditec, Inc. Device for positioning an implant in a target area of an eye
WO2022081609A1 (en) * 2020-10-14 2022-04-21 New World Medical, Inc. Intraocular drainage tube with valve
US11540940B2 (en) 2021-01-11 2023-01-03 Alcon Inc. Systems and methods for viscoelastic delivery
JP6971003B1 (en) * 2021-08-16 2021-11-24 裕貴 田邊 Glaucoma tube
JP2023026840A (en) * 2021-08-16 2023-03-01 裕貴 田邊 glaucoma tube

Similar Documents

Publication Publication Date Title
US3788327A (en) Surgical implant device
EP0773759B1 (en) Glaucoma implant with a temporary flow-restricting seal
US5558629A (en) Glaucoma implant
US4402681A (en) Artificial implant valve for the regulation of intraocular pressure
US6050970A (en) Method and apparatus for inserting a glaucoma implant in an anterior and posterior segment of the eye
US4457757A (en) Device for draining aqueous humour
US5626559A (en) Ophthalmic device for draining excess intraocular fluid
US5127901A (en) Implant with subconjunctival arch
US5681275A (en) Ophthalmological device with adaptable multiple distribution plates
US5041081A (en) Ocular implant for controlling glaucoma
US5397300A (en) Glaucoma implant
US4554918A (en) Ocular pressure relief device
US5785674A (en) Device and method for treating glaucoma
US5411473A (en) Medical valve
CA2708379C (en) Intraocular implant and delivery device for implantation
US5702414A (en) Method of implanting an intraocular implant
US8353856B2 (en) Glaucoma drainage shunts and methods of use
US5616118A (en) Uniquely shaped ophthalmological device
US5743868A (en) Corneal pressure-regulating implant device
US7481816B2 (en) Intraocular implant, delivery device, and method of implantation
US11779489B2 (en) Apparatus for treating excess intraocular fluid having an elastic membrane
US20030236483A1 (en) Dual drainage ocular shunt for glaucoma
US20210196517A1 (en) Apparatus for treating excess intraocular fluid having an elastic membrane
WO1994002081A1 (en) Eye implant suitable for relief of glaucoma
WO1994002081A9 (en) Eye implant suitable for relief of glaucoma