US2621145A - Bone mat compositions - Google Patents

Bone mat compositions Download PDF

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US2621145A
US2621145A US110743A US11074349A US2621145A US 2621145 A US2621145 A US 2621145A US 110743 A US110743 A US 110743A US 11074349 A US11074349 A US 11074349A US 2621145 A US2621145 A US 2621145A
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bone
particles
strip
mat
plasma
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US110743A
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Machteld E Sano
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane

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  • This invention relates to the eld of bone surgery and is directed particularly to the provision of a flexible strip comprising particles of bone held together by a fibrin network and sufficiently flexible to permitthe formation of a rolled strip.
  • the purpose of the present invention ls to provide a composition of bone particles which will promote the assimilation of the bone by the host and which can be readily obtained and which will be easy to use.
  • the present invention provides a flexible mat comprising, in combination, a multiplicity of bone particles enmeshed in a brin network, the entire composition being adapted for use in certain fields of bone surgery in place of the bone grafts heretofore used.
  • Fig. I1 is a plan view of a portion of iiexible strip comprising bone particles enmeshed in a brin network on a cellophane carrier;
  • Fig. 2 is a cross section taken through the lines II-II of Fig. 1;
  • Fig. 3 is a perspective view showing the flexible strip of Fig. 1 in roll form and;
  • Fig. 4 is a semi-schematic plan view greatly enlarged of a portion of a flexible strip comprising bone dust particles enmeshed in a fibrin network.
  • a multiplicity of bone particles I are shown enmeshed in a fibrin network 2.
  • the bone mat thus formed is supported by a carrier strip 3 comprising a thin exible plas- .tic material such as cellophane.
  • pieces of bone, including the cortex are obtained under sterile conditions from animals but preferably from humans, and these bones are ground by means of a bone grinder.
  • the sizes of ⁇ bone particles may vary from bone dust where the particle size is of the order of T16 mm. to particles which may be 4 mm. in diameter or more. It is preferable, however, to providebone particles of 'substantially the same size for a given bone mat composition. I have found it advantageous to provide bone particles of the following sizes:
  • This strip for convenience may be about 5 cm. wide.
  • the previously prepared bone particles are then sprinkled on the sterile strip in a thin layer leaving an unsprinkled edge free of bone particles from 2-3 mm. from each side and end of the flexible carrier strip.
  • the container or glass plate is then Vshaken gently to provide an even layer.
  • Citrated or heparinized plasma either human or animal, is then sprayed or drippedl on the thin layer of bone particles in sufficient quantity to wet the entire surface. Thisvwill vary according to the size of the bone particles but will be approximately l/2 cc. of plasma per 2 square cm. of bone particle layer.
  • the plasma should be sterile and not over 24 hours should elapse between the time of its collection and the time of its use.
  • thromboplastin containing 500 units per cc. or more is sprayed over the bone and plasma layer, it being sufficient to use 1/4 cc. of thromboplastin per 2 square cm. of surface.
  • the treated layer with its mixture of plasma and thromboplastin is next gently pressed with the fleshy part of the foreiinger or a small rubber cushion and the edges of the strip are gently patted inwards.
  • the sterile container or glass plate is gently tilted for about 5 minutes to let the excess iiuid drain and the drained layer is then gently pressed as in the previous pressing step.
  • the bone mat thus formed supported by the cello- 3 phane carrier strip may now be rolled upon itself, placed in a sterile tin container and sealed air-tight or it may be stored in a glass container and sealed air-tight.
  • the procedure outlined above for preparing the bone mat composition of the present invention is applicable particularly in the case where human plasma is used. In the event that animal plasma is used, best results are obtained if the steps involving spraying with plasma and then with thromboplastin are repeated. It is also possible to form a thicker layer of bone mat by repeating the entire process a number of times and then building up a succession of layers.
  • thromboplastin to the plasma, which contains brinogen, results in the formation of a brin network which enmeshesy the bone particles and holds them together thus forming a bone mat.
  • the exible plastic carrier strip serves to support the bone. particle layer during the treatment with plasma and thromboplastin and permits rolling so that the strip canbe effectively stored.
  • the bone mat comprising bone particles enmeshed in a brin network can be removed from the carrier strip by a roll-off operation as shown in Fig. 3 of the drawings.
  • the nal bone mat composition ofthe present invention may b e looked upon as the bone particle-brin network layer and it is possible to store this layer either flat or rolled. For convenience it is desirable to store the bone mat layer rolled and with the carrier strip. affixed. At the time of ultimate use the bone particle-nbrin mat is removed from the carrier strip.
  • the surgeon In using the composition of the present invention in bone surgery, the surgeon merely unrolls the slightly humid bone mat and removes it from the plastic carrier strip.
  • a strip of bonemat prepared with 1-2'mm. ⁇ bone(particles ⁇ which is 5 cm.
  • the bonematof the present invention encourages:v a morel rapid regrowth of bone bythe body as compared to the ratel of regrowth where the usualbone grarftpmethod is used.
  • a bone roll for use in bone surgery in promoting regrowth of bone comprising a rolled flexible strip consisting of a multiplicity of unboiled particles of ground whole bone enmeshed in a fibrin network and held together thereby.
  • a iiexible strip for use in bone surgery in promoting regrowth of bone comprising a multiplicity of unboiled particles of ground whole bone enmeshed in fibrin in the form of a bone particlebrin network and a thin, flexible carrier strip support for said network.
  • the invention of claim 2 further characterized by the fact that the carrier strip consists of a sterile strip of cellophane.
  • a bone roll for use in bone surgery in promoting regrowth of bone comprising a rolled flexible strip consisting of a multiplicity of unboiled particles of ground whole bone held together by a fibrin network and supported on a thin, ilexible carrier strip.
  • a flexible mat which can be rolled into any desired length, thickness and shape for use in bone surgery in promoting. regrowth ⁇ of bone comprising a strip consisting of a multiplicity of unboiled particles ofy ground whole boneenmeshed in a fibrin network and held together thereby.

Description

Dec. 9, 1952 M. E. sANo 2,621,145
BONE MAT COMPOSITIONS Filed Aug. 17, 1949 FGzl- TNESSES l INVENTOR.-
A TTORN E YS Patenied Dec. 9, 1952 UNITED STATES 'TENT OFFICE BONE MAT COMPSITIONS Machteld E. Sano, Philadelphia, Pa.
Application August 17, 1949, Serial No'. 110,743
Claims. (Cl. 167-84) This invention relates to the eld of bone surgery and is directed particularly to the provision of a flexible strip comprising particles of bone held together by a fibrin network and sufficiently flexible to permitthe formation of a rolled strip.
In the eld of bone surgery it is frequently required to replace sections of bone or fragments thereof. The physiological replacement of large pieces of bone or fragments in the human or animal body requires time and in certain unfavorable instances will not take place. In order to bridge the gap and to thus facilitate the process of regrowth, the surgeon introduces a piece of bone which he may obtain from a bone bank or which he may remove from a healthy bone of the patient. Specially treated animal bones have also been used in this way. In any of these three instances the process is time consuming. One of the objections to the use of bone grafts of this kind is the accurate cutting and fitting which is time consuming. A further diiiiculty in the methods heretofore employed has been in readily obtaining bone grafts of the desired shapes and lengths.
The purpose of the present invention ls to provide a composition of bone particles which will promote the assimilation of the bone by the host and which can be readily obtained and which will be easy to use. To further this object, the present invention provides a flexible mat comprising, in combination, a multiplicity of bone particles enmeshed in a brin network, the entire composition being adapted for use in certain fields of bone surgery in place of the bone grafts heretofore used.
A preferred process for preparing the composition which is the subject of the present invention is described hereinafter in detail, reference being had to the accompanying drawings in which Fig. I1 is a plan view of a portion of iiexible strip comprising bone particles enmeshed in a brin network on a cellophane carrier;
Fig. 2 is a cross section taken through the lines II-II of Fig. 1;
Fig. 3 is a perspective view showing the flexible strip of Fig. 1 in roll form and;
Fig. 4 is a semi-schematic plan view greatly enlarged of a portion of a flexible strip comprising bone dust particles enmeshed in a fibrin network.
In the drawings a multiplicity of bone particles I are shown enmeshed in a fibrin network 2. The bone mat thus formed is supported by a carrier strip 3 comprising a thin exible plas- .tic material such as cellophane. In preparing the bone particles l, pieces of bone, including the cortex, are obtained under sterile conditions from animals but preferably from humans, and these bones are ground by means of a bone grinder. The sizes of` bone particles may vary from bone dust where the particle size is of the order of T16 mm. to particles which may be 4 mm. in diameter or more. It is preferable, however, to providebone particles of 'substantially the same size for a given bone mat composition. I have found it advantageous to provide bone particles of the following sizes:
-1% mm., or bone dust 1-'2 mm. in diameter 2-'4 jmm. in diameter This provides a selectionin making up a given quantity of the bone mat composition of the present invention;
A sterile flexible strip made of a plastic material such as cellophane or the like, is placed in a sterile container or on a sterile' glass plate. This strip for convenience may be about 5 cm. wide. The previously prepared bone particles are then sprinkled on the sterile strip in a thin layer leaving an unsprinkled edge free of bone particles from 2-3 mm. from each side and end of the flexible carrier strip. The container or glass plate is then Vshaken gently to provide an even layer. Citrated or heparinized plasma, either human or animal, is then sprayed or drippedl on the thin layer of bone particles in sufficient quantity to wet the entire surface. Thisvwill vary according to the size of the bone particles but will be approximately l/2 cc. of plasma per 2 square cm. of bone particle layer. The plasma should be sterile and not over 24 hours should elapse between the time of its collection and the time of its use.
Following the application of plasma, thromboplastin containing 500 units per cc. or more is sprayed over the bone and plasma layer, it being sufficient to use 1/4 cc. of thromboplastin per 2 square cm. of surface. The treated layer with its mixture of plasma and thromboplastin is next gently pressed with the fleshy part of the foreiinger or a small rubber cushion and the edges of the strip are gently patted inwards. The sterile container or glass plate is gently tilted for about 5 minutes to let the excess iiuid drain and the drained layer is then gently pressed as in the previous pressing step. The bone mat thus formed supported by the cello- 3 phane carrier strip may now be rolled upon itself, placed in a sterile tin container and sealed air-tight or it may be stored in a glass container and sealed air-tight.
The procedure outlined above for preparing the bone mat composition of the present invention is applicable particularly in the case where human plasma is used. In the event that animal plasma is used, best results are obtained if the steps involving spraying with plasma and then with thromboplastin are repeated. It is also possible to form a thicker layer of bone mat by repeating the entire process a number of times and then building up a succession of layers.
The addition of the thromboplastin to the plasma, which contains brinogen, results in the formation of a brin network which enmeshesy the bone particles and holds them together thus forming a bone mat.
It will be apparent that the exible plastic carrier strip serves to support the bone. particle layer during the treatment with plasma and thromboplastin and permits rolling so that the strip canbe effectively stored. The bone mat comprising bone particles enmeshed in a brin network can be removed from the carrier strip by a roll-off operation as shown in Fig. 3 of the drawings.
The nal bone mat composition ofthe present invention may b e looked upon as the bone particle-brin network layer and it is possible to store this layer either flat or rolled. For convenience it is desirable to store the bone mat layer rolled and with the carrier strip. affixed. At the time of ultimate use the bone particle-nbrin mat is removed from the carrier strip.
In using the composition of the present invention in bone surgery, the surgeon merely unrolls the slightly humid bone mat and removes it from the plastic carrier strip. A strip of bonemat prepared with 1-2'mm.` bone(particles` which is 5 cm.
wide and V10 cm. long can be rolled withoutthe plastic carrier strip into a bone roll 5 cm. long and 11/2 to 2 om: in diameter whiehrmay be used in ways which will be apparent to the skilled surgeon.
In addition to being much easier to useand less time consuming, the bonematof the present invention encourages:v a morel rapid regrowth of bone bythe body as compared to the ratel of regrowth where the usualbone grarftpmethod is used.
In describing the present invention a specific preferred example has been given. However, it will be understood thatv various modications may be employed withoutdepartingfrom the spirit of the present invention as set forth inthe appended claims. Likewise if prepared on a large scale certain modications will suggest themselves as being applicable to mass production methods.
Having thus described my invention, I claim:
1. A bone roll for use in bone surgery in promoting regrowth of bone comprising a rolled flexible strip consisting of a multiplicity of unboiled particles of ground whole bone enmeshed in a fibrin network and held together thereby.
2. A iiexible strip for use in bone surgery in promoting regrowth of bone comprising a multiplicity of unboiled particles of ground whole bone enmeshed in fibrin in the form of a bone particlebrin network and a thin, flexible carrier strip support for said network.
3. The invention of claim 2 further characterized by the fact that the carrier strip consists of a sterile strip of cellophane.
4. A bone roll for use in bone surgery in promoting regrowth of bone comprising a rolled flexible strip consisting of a multiplicity of unboiled particles of ground whole bone held together by a fibrin network and supported on a thin, ilexible carrier strip.
5. A flexible mat which can be rolled into any desired length, thickness and shape for use in bone surgery in promoting. regrowth` of bone comprising a strip consisting of a multiplicity of unboiled particles ofy ground whole boneenmeshed in a fibrin network and held together thereby.
MACHTELD E. SANO;
REFERENCES CITED:
The following references arel of record in the file ofthis patent:
UNITED=STATES PA'IEN'IS Number Name Date 2,241,868. Reimann May 13, 1941 2,398,077 Smith Apr. 9, 1946 2,433,299 Seegers Dec. 23, 1947 2,485,791 Tucker Oct. 25, 1949 2,492,458 Bering. Dec. 27, 1949 2,517,772 Doub Aug. 8, 1950 FOREIGN PATENTS Number Country` Date 18,601 Great Britain -.A. D. 1897 474,093 Germany Mar. 26, 1929 OTHER REFERENCES Drug and Cosmetic Industry, May 1937, page 727, Stimulating Bone Growth.
Blaine, Experimental Observations Annals of Surgery, January 1947, pagesf102 to 106, 108 to 114, especially at page 108.

Claims (1)

1. A BONE ROLL FOR USE IN BONE SURGERY IN PROMOTING REGROWTH OF BONE COMPRISING A ROLLED FLEXIBLE STRIP CONSISTING OF A MULTIPLICITY OF UNBOILED
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Cited By (65)

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US2690198A (en) * 1950-01-18 1954-09-28 Anderson Roger Saw tooth cutter for dividing bone for orthopedic operations
US2721555A (en) * 1952-12-03 1955-10-25 John A Jenney Dermatome
US3022783A (en) * 1962-02-27 Method of preserving tissue such
US3126884A (en) * 1964-03-31 Method of preserving animal tissue
US4186448A (en) * 1976-04-16 1980-02-05 Brekke John H Device and method for treating and healing a newly created bone void
EP0070328A1 (en) * 1981-07-21 1983-01-26 Theurer, Karl Eugen, Prof.Dr.med. Use of egg membranes and umbilical cord in unmodified or modified form
US4430760A (en) * 1981-12-18 1984-02-14 Collagen Corporation Nonstress-bearing implantable bone prosthesis
US4553272A (en) * 1981-02-26 1985-11-19 University Of Pittsburgh Regeneration of living tissues by growth of isolated cells in porous implant and product thereof
US4743229A (en) * 1986-09-29 1988-05-10 Collagen Corporation Collagen/mineral mixing device and method
AU578108B2 (en) * 1984-07-06 1988-10-13 Collagen Corporation Methods of bone repair using collagen
US4789663A (en) * 1984-07-06 1988-12-06 Collagen Corporation Methods of bone repair using collagen
US5000746A (en) * 1987-08-11 1991-03-19 Friedrichsfeld Gmbh Keramik- Und Kunststoffwerke Wound covering having connected discrete elements
US5356630A (en) * 1989-02-22 1994-10-18 Massachusetts Institute Of Technology Delivery system for controlled release of bioactive factors
US5403317A (en) * 1990-06-28 1995-04-04 Bonutti; Peter M. Apparatus and method for tissue removal
US5769897A (en) * 1991-12-13 1998-06-23 Haerle; Anton Synthetic bone
US5935594A (en) * 1993-10-28 1999-08-10 Thm Biomedical, Inc. Process and device for treating and healing a tissue deficiency
US5944721A (en) * 1997-12-08 1999-08-31 Huebner; Randall J. Method for repairing fractured bone
US5981825A (en) * 1994-05-13 1999-11-09 Thm Biomedical, Inc. Device and methods for in vivo culturing of diverse tissue cells
US6030635A (en) * 1998-02-27 2000-02-29 Musculoskeletal Transplant Foundation Malleable paste for filling bone defects
US6045555A (en) * 1994-11-09 2000-04-04 Osteonics Corp. Bone graft delivery system and method
WO2000040177A1 (en) * 1999-01-05 2000-07-13 Lifenet Composite bone graft, method of making and using same
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US20010008979A1 (en) * 1991-08-12 2001-07-19 Bonutti Peter M. Tissue press and system
US6326018B1 (en) 1998-02-27 2001-12-04 Musculoskeletal Transplant Foundation Flexible sheet of demineralized bone
US6437018B1 (en) 1998-02-27 2002-08-20 Musculoskeletal Transplant Foundation Malleable paste with high molecular weight buffered carrier for filling bone defects
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US6630000B1 (en) 1991-08-12 2003-10-07 Bonutti 2003 Trust-A Method of using body tissue
US6632247B2 (en) 2000-03-22 2003-10-14 Synthes (Usa) Implants formed of coupled bone
US6652595B1 (en) 1996-03-25 2003-11-25 Davol Inc. Method of repairing inguinal hernias
USRE38522E1 (en) * 1998-02-27 2004-05-25 Musculoskeletal Transplant Foundation Malleable paste for filling bone defects
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US20050192600A1 (en) * 2004-02-24 2005-09-01 Enrico Nicolo Inguinal hernia repair prosthetic
US6986788B2 (en) 1998-01-30 2006-01-17 Synthes (U.S.A.) Intervertebral allograft spacer
US6990982B1 (en) 1990-06-28 2006-01-31 Bonutti Ip, Llc Method for harvesting and processing cells from tissue fragments
US6998135B1 (en) 1998-02-27 2006-02-14 Musculoskeletal Transplant Foundation Demineralized corticocancellous bone sheet
EP1701672A2 (en) * 2003-12-19 2006-09-20 Osteotech, Inc. Tissue-derived mesh for orthopedic regeneration
US7226482B2 (en) 2003-09-02 2007-06-05 Synthes (U.S.A.) Multipiece allograft implant
US7232464B2 (en) 2002-02-19 2007-06-19 Synthes (Usa) Intervertebral implant
US7235079B2 (en) 2004-11-18 2007-06-26 Acumed Llc Composite bone fasteners
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DE474093C (en) * 1927-07-30 1929-03-26 Erich Freund Dr Process for the production of hemostatic and wound-healing bandages and plasters
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US2433299A (en) * 1944-01-22 1947-12-23 Parke Davis & Co Blood coagulant and method of preserving same
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GB189718601A (en) * 1897-08-11 1898-07-30 Alfred Sykes A New or Improved Surgical Dressing.
DE474093C (en) * 1927-07-30 1929-03-26 Erich Freund Dr Process for the production of hemostatic and wound-healing bandages and plasters
US2241868A (en) * 1937-09-10 1941-05-13 Hall Lab Inc Method of processing blood
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US2433299A (en) * 1944-01-22 1947-12-23 Parke Davis & Co Blood coagulant and method of preserving same
US2492458A (en) * 1944-12-08 1949-12-27 Jr Edgar A Bering Fibrin foam
US2517772A (en) * 1945-05-11 1950-08-08 Parke Davis & Co Neutralized oxidized cellulose products
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Cited By (146)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3022783A (en) * 1962-02-27 Method of preserving tissue such
US3126884A (en) * 1964-03-31 Method of preserving animal tissue
US2690198A (en) * 1950-01-18 1954-09-28 Anderson Roger Saw tooth cutter for dividing bone for orthopedic operations
US2721555A (en) * 1952-12-03 1955-10-25 John A Jenney Dermatome
US4186448A (en) * 1976-04-16 1980-02-05 Brekke John H Device and method for treating and healing a newly created bone void
US4553272A (en) * 1981-02-26 1985-11-19 University Of Pittsburgh Regeneration of living tissues by growth of isolated cells in porous implant and product thereof
EP0070328A1 (en) * 1981-07-21 1983-01-26 Theurer, Karl Eugen, Prof.Dr.med. Use of egg membranes and umbilical cord in unmodified or modified form
US4430760A (en) * 1981-12-18 1984-02-14 Collagen Corporation Nonstress-bearing implantable bone prosthesis
US4789663A (en) * 1984-07-06 1988-12-06 Collagen Corporation Methods of bone repair using collagen
AU578108B2 (en) * 1984-07-06 1988-10-13 Collagen Corporation Methods of bone repair using collagen
US4743229A (en) * 1986-09-29 1988-05-10 Collagen Corporation Collagen/mineral mixing device and method
US5000746A (en) * 1987-08-11 1991-03-19 Friedrichsfeld Gmbh Keramik- Und Kunststoffwerke Wound covering having connected discrete elements
US5629009A (en) * 1989-02-22 1997-05-13 Massachusetts Institute Of Technology Delivery system for controlled release of bioactive factors
US5356630A (en) * 1989-02-22 1994-10-18 Massachusetts Institute Of Technology Delivery system for controlled release of bioactive factors
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