US20130245654A1 - Atherectomy device supported by fluid bearings - Google Patents
Atherectomy device supported by fluid bearings Download PDFInfo
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- US20130245654A1 US20130245654A1 US13/875,632 US201313875632A US2013245654A1 US 20130245654 A1 US20130245654 A1 US 20130245654A1 US 201313875632 A US201313875632 A US 201313875632A US 2013245654 A1 US2013245654 A1 US 2013245654A1
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- drive shaft
- fluid
- distal
- proximal
- solid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/32—Surgical cutting instruments
- A61B17/3205—Excision instruments
- A61B17/3207—Atherectomy devices working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions
- A61B17/320758—Atherectomy devices working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions with a rotating cutting instrument, e.g. motor driven
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/32—Surgical cutting instruments
- A61B17/3203—Fluid jet cutting instruments
- A61B17/32037—Fluid jet cutting instruments for removing obstructions from inner organs or blood vessels, e.g. for atherectomy
Definitions
- the present invention provides a rotational atherectomy device for removing a stenotic lesion from within a vessel of a patient. More specifically, the invention relates to a rotational atherectomy device for removing or reducing stenotic lesions in blood vessels such as a human artery by rotating an abrasive element within the vessel to partially or completely ablate the unwanted material.
- Atherosclerosis the clogging of arteries, is a leading cause of coronary heart disease.
- Blood flow through the peripheral arteries e.g., carotid, femoral, renal, etc.
- a conventional method of removing or reducing blockages in blood vessels is known as rotational atherectomy.
- a long guidewire is advanced into the diseased blood vessel and across the stenotic lesion.
- a hollow drive shaft is then advanced over the guidewire. The distal end of the drive shaft terminates in a burr provided with an abrasive surface formed from diamond grit or diamond particles.
- the burr is positioned against the occlusion and the drive shaft rotated at extremely high speeds (e.g., 20,000-160,000 rpm). As the burr rotates, the physician slowly advances it so that the abrasive surface of the burr scrapes against the occluding tissue and disintegrates it, reducing the occlusion and improving the blood flow through the vessel.
- extremely high speeds e.g., 20,000-160,000 rpm
- Rotational angioplasty is frequently used to remove atherosclerotic or other blocking material from stenotic (blocked) coronary arteries and other blood vessels.
- atherectomy is frequently used to remove atherosclerotic or other blocking material from stenotic (blocked) coronary arteries and other blood vessels.
- abraded particles can migrate along the blood vessel distally and block very small diameter vessels including capillaries of the heart muscle itself
- the effect of the particulate debris produced by this procedure is of major concern to physicians who practice in this field.
- the existence of particulate matter in the blood stream is undesirable and can cause potentially life-threatening complications, especially if the particles are over a certain size.
- a rotational atherectomy device described in U.S. Pat. No. 5,681,336 (to Clement et al), has been proposed which attempts to prevent migration of abraded particles along the blood stream by removing the ablated material from the blood vessel whilst the device is in use.
- the rotational atherectomy device known from U.S. Pat. No. 5,681,336 (to Clement et al.) has a complicated construction and is difficult to manufacture on a commercial scale.
- WO 2006/126076 Two most preferred embodiments of the Rotational Atherectomy Device with Solid Support Elements are described in WO 2006/126076. Both embodiments comprise an abrasive element and a pair of solid support elements mounted to a hollow drive shaft formed from a torque transmitting coil and a fluid impermeable membrane. In both preferred embodiments, the abrasive element is located proximal to and spaced away from the distal end.
- the solid support elements described in WO 2006/126076 are rounded. One of them is located at the distal end of the drive shaft and is referred to as the distal solid support element. The other is located proximal to and spaced away from the abrasive element and is referred to as the proximal distal support element.
- the abrasive element has its centre of mass spaced away from the longitudinal or rotational axis of the drive shaft.
- both the distal and the proximal solid support elements also have their centres of mass spaced radially away from the longitudinal or rotational axis of the drive shaft, the centre of mass of each of the two solid support elements being located diametrically opposite to the centre of mass of the abrasive clement with respect to the longitudinal axis of the drive shaft so that the distal and proximal solid support elements act as counterweights with respect to the abrasive element when the drive shaft rotates.
- the distal and proximal solid support elements are located in the same longitudinal plane as the centre of mass of the abrasive element, the longitudinal plane extending through the longitudinal or rotational axis of the drive shaft.
- the abrasive element and the solid support elements have their centres of mass coaxial with the longitudinal or rotational axis of the fluid impermeable drive shaft.
- pressurised fluid enters treated vessel only through a distal end opening of the fluid impermeable lumen of the drive shaft.
- a rotational atherectomy device for removing a stenotic tissue from a vessel of a patient, the device comprising a rotatable, flexible, hollow drive shaft having a distal end, an abrasive element mounted to the drive shaft proximal to and spaced away from a distal solid support element mounted at the distal end of the drive shaft, the distal solid support element having a rounded outer surface and comprising an outflow channel extending through the solid distal support element, the outflow channel having an outflow opening in said rounded outer surface, the drive shaft comprising a torque transmitting coil and at least one fluid impermeable membrane forming a fluid impermeable lumen for the antegrade flow of fluid along the torque transmitting coil into the outflow channel of the solid distal support element such that, during rotation of the drive shaft, said outflow opening of the outflow channel is facing an inner surface of a vessel being treated so that a flow of fluid out of said outflow opening forms a layer of fluid between the solid distal
- the fluid impermeable drive shaft is provided with a solid proximal support element located proximal to and spaced away from the abrasive element, the membrane that forms a fluid impermeable lumen for the antegrade flow of fluid along the torque transmitting coil into the outflow channel of the distal solid support element also forming a lumen for the antegrade flow of fluid along the torque transmitting coil into an outflow channel extending through said solid proximal support element, the solid proximal support element having a rounded outer surface, said outflow channel having an outflow opening in the rounded outer surface of the solid proximal support element such that, during rotation of the drive shaft, said outflow opening on the outer surface of the solid proximal support element is facing an inner surface of a treated vessel so that a flow of fluid out of said outflow opening forms a layer of fluid between the solid proximal support element and a wall of the treated vessel, said layer of fluid forming a fluid bearing between the rotating solid proximal support
- the drive shaft preferably has a longitudinal axis and the solid distal support element has a centre of mass which is coaxial with the longitudinal axis of the drive shaft, said distal support element having a plurality of outflow channels that extend through the distal support element in a radially outward direction with respect to the longitudinal axis of the drive shaft and have their outflow openings spaced around the circumference of the solid distal support element such that, during rotation of the drive shaft, a flow of fluid through the outflow openings forms a layer of fluid between the solid distal support element and a wall of the vessel being treated, said layer of fluid forming a fluid bearing between the rotating solid distal support element and the wall of the vessel being treated.
- the centre of mass of the abrasive element may either be coaxial with the longitudinal axis of the drive shaft or, spaced radially away from the longitudinal axis of the drive shaft.
- the solid proximal support element may have a centre of mass coaxial with the longitudinal axis of the drive shaft, said proximal support element having a plurality of outflow channels extending through the solid proximal support element in a radially outward direction with respect to the longitudinal axis of the drive shaft and having their outflow openings located around the circumference of the solid proximal support element such that, during rotation of the drive shaft, a flow of fluid out of the outflow openings forms a layer of fluid between the solid proximal support element and a wall of the vessel being treated, said layer of fluid forming a fluid bearing between the rotating solid proximal support element and the wall of the vessel being treated.
- the centre of mass of the abrasive element may either be coaxial with the longitudinal axis of the drive shaft or, spaced radially away from the longitudinal axis of the drive shaft.
- the solid distal support element may have its centre of mass spaced radially away from the longitudinal axis of the drive shaft in one direction so that it acts as a counterweight to the abrasive element, which has its centre of mass spaced radially away from the longitudinal axis of the drive shaft in a diametrically opposite direction.
- the centres of mass of both distal and proximal solid support elements may be spaced radially away from a longitudinal axis of the drive shaft but in a direction diametrically opposite to the direction in which the abrasive element is spaced radially away from the longitudinal axis of the drive shaft so that the distal and proximal solid support elements act as counterweights to the abrasive element.
- the present invention covers two most preferred embodiments in one of which the solid support elements are asymmetrical with respect to the longitudinal axis of the drive shaft. In the other preferred embodiment, the solid support elements are symmetric with respect to the longitudinal axis of the drive shaft. However, it will be appreciated that, in all the embodiments, the asymmetric and symmetric solid support elements comprise outflow channels located such that, in the rotating drive shaft, fluid flowing out of said channels forms fluid bearings between outer walls of said solid support elements and the wall of the treated vessel.
- distal and proximal ends and to flow of fluid in an “antegrade” and “retrograde” direction.
- distal end is considered to refer to the end of the device which is inserted into the vessel in the body of the patient and the proximal end is the end of the device which remains outside the body of the patient and which can be connected to a handle assembly for both rotating and longitudinally moving the drive shaft within the treated vessel.
- proximal flow refers to a direction of flow from the proximal towards the distal end of the device.
- retrograde refers to a direction of flow in the opposite direction, i.e. from the distal towards the proximal end of the device.
- FIG. 1 illustrates in a longitudinal cross-section a distal portion of one preferred embodiment of the rotational atherectomy device of the invention, this embodiment comprising asymmetric solid support elements and illustrating the location of outflow channels which extend through said solid support elements;
- FIG. 2 illustrates the device of FIG. 1 located in a vessel being treated and shows how the device can be used to abrade a stenotic lesion while forming fluid bearings between rounded outer surfaces of asymmetric solid support elements located distal and proximal to the abrasive element;
- FIG. 3 illustrates in a longitudinal cross-section a distal portion of one preferred embodiment of the rotational atherectomy device of the invention, this embodiment comprising symmetric solid support elements located distal and proximal to the symmetric abrasive element and illustrates location of outflow channels which extend through said solid support elements; and
- FIG. 4 illustrates the device of FIG. 3 located in a vessel being treated and shows how the device can be used to abrade a stenotic lesion in a curved vessel. This Figure also shows how fluid bearings are formed between the rounded outer surfaces of symmetric solid support elements and the wall of the treated vessel.
- the antegrade flow of fluid is indicated by arrows “FF” and the flow of fluid in a retrograde direction is indicated by arrows marked “R”.
- Abraded particles AP abraded from the stenotic lesion 330 are aspirated into a lumen of a drive shaft sheath 400 so that the retrograde flowing fluid and the abraded particles entrained in said fluid can be removed from the treated vessel and out of the patient's body.
- a rotational atherectomy device for removing a stenotic lesion from within a vessel of a patient using an abrasive element mounted to a rotatable, flexible, hollow drive shaft formed by a torque transmitting coil and a fluid impermeable membrane.
- the drive shaft has a longitudinal axis of rotation and is provided with two rounded solid support elements.
- Each of the two solid support elements is spaced away from the abrasive element and includes at least one outflow channel which is directed radially outward and communicates a lumen of the drive shaft with a vascular space of the treated vessel, one of said solid support elements is a distal solid support element and is located at a distal end of the drive shaft and the other is a proximal solid support element and is located proximal to the abrasive element.
- each of the distal and proximal solid support elements has a rounded surface and is spaced equally from the abrasive element which extends around the entire circumference of the drive shaft.
- the abrasive element and each of the two solid support elements are symmetric with respect to the rotational (longitudinal) axis of the drive shaft. In another embodiment of the invention the abrasive element and the solid support elements have their centres of mass spaced radially away from the rotational (longitudinal) axis of the drive shaft.
- Each outflow channel has its own axis and each of the solid support elements has at least one outflow channel located such that its axis comprises an acute angle of at least seventy five (75) degrees with the longitudinal (rotational) axis of the drive shaft.
- each of the solid support elements has at least one outflow channel located such that its axis comprises an angle of about (90) degrees with the longitudinal (rotational) axis of the drive shaft.
- each of the symmetric solid support elements has at least a few outflow channels equally spaced around the maximum circumference of the support element, each of said outflow channels having an axis which comprises an angle of about ninety (90) degrees with the longitudinal (rotational) axis of the drive shaft.
- at least one outflow channel is located such that in a rotating drive shaft fluid which flows through the outflow channel along its axis forms at least a thin layer of fluid between the solid support element and the wall of the treated vessel.
- FIG. 1 illustrates, in a longitudinal cross-section, a distal portion of one preferred embodiment of the rotational atherectomy device of an embodiment of the invention.
- the rotational atherectomy device is comprised of an asymmetric abrasive element 101 which extends around the entire circumference of the drive shaft 2 proximal to and spaced away from a distal end 6 of the drive shaft.
- the fluid impermeable drive shaft 2 is comprised by a fluid impermeable membrane 3 which lines a torque transmitting coil 4 . Both the torque transmitting coil 4 and the fluid impermeable membrane 3 extend distally beyond the abrasive element 101 .
- FIG. 1 illustrates an asymmetric distal support element 10 which has its centre of mass spaced radially away from the longitudinal (rotational) axis W-W of the drive shaft 2 .
- the Figure illustrates that at least one outflow channel 20 which extends through a heavier portion 60 of the asymmetric distal support element 10 , the axis K-K of the outflow channel 20 comprises an acute angle a of about ninety (90) degrees with the longitudinal (rotational) axis W-W of the drive shaft.
- there may be a plurality of outflow channels 20 and the axes of these channels may form an acute angle of up to 30 degrees with axis K-K of the most important outflow channel.
- axis K-K being oriented perpendicular to the longitudinal axis of the drive shaft.
- axis K-K of at least one outflow channel 20 passes through or close to the centre of mass of the asymmetric distal solid support element.
- FIGS. 1 and 2 illustrate that a portion of flushing fluid FF flowing in an antegrade direction through the drive shaft 2 is redirected through the outflow channel 20 into a vascular space of the treated vessel.
- FIG. 2 illustrates that in a rotating drive shaft centrifugal force attempts to press a rotating asymmetric solid distal support element 10 against the wall 300 of the treated vessel but fluid exiting through the outflow channel 20 along its axis K-K and forms an acute angle ⁇ of over 75 degrees with an inner surface of a wall 300 of the treated vessel so that fluid flowing through the outflow channel 20 forms a thin layer of fluid between the solid support element 10 and an inner surface of the treated vessel.
- This thin layer of fluid acts as a fluid bearing between the asymmetric distal solid support element 10 and a wall 300 of the treated vessel.
- At least a portion of fluid flowing through the outflow channel 20 flows in a retrograde direction, as indicated by arrows marked “R”, and entrains abraded particles AP removed from the stenotic lesion 330 .
- the retrograde flowing flushing fluid R and entrained abraded particles AP are aspirated into a lumen of the drive shaft sheath 400 .
- FIG. 1 illustrates an asymmetric proximal support element 10 p which has its centre of mass spaced radially away from the longitudinal (rotational) axis W-W of the drive shaft 2 .
- the Figure illustrates that at least one outflow channel 20 p extends through a heavier portion 60 p of the asymmetric proximal support element 10 p.
- the outflow channel 20 p has an axis L-L which forms an acute angle a of about ninety (90) degrees with the longitudinal (rotational) axis W-W of the drive shaft.
- outflow channels 20 p there may be a plurality of outflow channels 20 p and the axes of these channels may form an acute angle of up to 30 degrees with axis L-L of the most important outflow channel that has its axis L-L oriented perpendicular to the longitudinal axis of the drive shaft.
- FIGS. 1 and 2 illustrate that a portion of flushing fluid FF flowing in an antegrade direction through the drive shaft 2 is redirected through the outflow channel 20 p into a vascular space of the treated vessel.
- FIG. 2 illustrates that in a rotating drive shaft centrifugal force attempts to press a rotating asymmetric solid proximal support element 10 p against the wall 300 of the treated vessel but fluid exiting through the outflow channel 20 p along its axis L-L forms an angle ⁇ of about ninety (90) degrees with an inner surface of a wall 300 of the treated vessel so that fluid flowing through the outflow channel 20 p forms a thin layer of fluid between the solid support element 10 p and an inner surface of the treated vessel.
- This thin layer of fluid acts as a fluid beating between the asymmetric distal solid support element 10 p and a wall 300 of the treated vessel.
- FIG. 3 illustrates a symmetric distal support element 10 s.
- the centre of mass of the symmetric distal support element 10 s coincides with the longitudinal (rotational) axis W-W of the drive shaft 2 .
- at least a few outflow channels 20 s should extend radially outward through the symmetric distal support element 10 s communicating a fluid impermeable lumen of the drive shaft 2 with a vascular space of the treated vessel.
- Preferably said outflow channels 20 s should be equally spaced around the maximum diameter circumference of the symmetric distal solid support element 20 s.
- an axis M-M of at least one outflow channel 20 s comprises an acute angle of over seventy five (75) degrees with the longitudinal (rotational) axis W-W of the drive shaft 2 .
- axis M-M of the outflow channel 20 s forms an angle a of about ninety (90) degrees with the longitudinal (rotational) axis W-W of the drive shaft.
- FIGS. 3 and 4 illustrate that a portion of flushing fluid FF flowing in an antegrade direction through the drive shaft 2 is redirected through the outflow channels 20 s into a vascular space of the treated vessel.
- FIG. 4 illustrates that, in a curved vessel, the drive shaft 2 attempts to maintain its straight configuration and therefore attempts to press both of the solid symmetric support elements towards the outer curvature of the vessel and the symmetric abrasive element 102 towards the inner curvature of the vessel.
- FIG. 4 illustrates that in a rotating drive shaft the axis M-M of the outflow channel 20 s forms an angle ⁇ of about ninety (90) degrees with an inner surface of a wall 300 of the treated vessel so that fluid flowing through the outflow channel 20 s along its axis M-M forms a thin layer of fluid between the solid support element 10 s and an inner surface of the treated vessel.
- This thin layer of fluid acts as a fluid bearing between the solid support element 10 s and a wall 300 of the treated vessel.
- At least a portion of the fluid flowing through the outflow channels 20 is flowing in a retrograde direction R and entrains abraded particles AP removed (abraded) by the symmetric abrasive element 102 from the stenotic lesion 360 located on the inner curvature of the vessel 300 .
- the retrograde flowing flushing fluid R is aspirated into a lumen of the drive shaft sheath 400 .
- FIG. 3 illustrates a symmetric proximal support element 10 sp .
- the centre of mass of the symmetric proximal support element 10 sp coincides with the longitudinal (rotational) axis of the drive shaft 2 .
- at least a few outflow channels 20 sp should extend radially outward through the symmetric proximal support element 10 sp communicating a fluid impermeable lumen of the drive shaft 2 with a vascular space of the treated vessel.
- said outflow channels 20 sp should be equally spaced around the maximum diameter circumference of the symmetric distal solid support element 20 sp .
- FIGS. 3 and 4 illustrate that a portion of flushing fluid FF flowing in an antegrade direction through the drive shaft 2 is redirected through the outflow channel 20 sp into a vascular space of the treated vessel.
- FIG. 4 illustrates that in a rotating drive shaft the axis N-N of the outflow channel 20 sp forms an angle ⁇ of about ninety (90) degrees with an inner surface of a wall 300 of the treated vessel so that fluid flowing through the outflow channel 20 sp along its axis N-N forms a thin layer of fluid between the proximal solid support element 10 sp and an inner surface of the treated vessel.
- This thin layer of fluid acts as a fluid bearing between the proximal solid support element 10 sp and a wall 300 of the treated vessel.
- FIG. 3 illustrates an embodiment in which a fluid impermeable membrane lines the torque transmitting coil.
- the fluid impermeable membrane is disposed around the torque transmitting coil.
- the device with symmetric support elements is not intended to be exclusively used in curved vessels but can also be used successfully in straight vessels.
Abstract
A rotational atherectomy device for removing a stenotic tissue from a vessel of a patient comprises a flexible hollow drive shaft and an abrasive element mounted to the drive shaft proximal to and spaced from a solid support element mounted at the distal end of the drive shaft, the solid support element having a rounded outer surface and an outflow channel with an outflow opening in said rounded outer surface. The drive shaft comprises a torque transmitting coil and at least one fluid impermeable membrane forming a fluid impermeable lumen for the antegrade flow of fluid into the outflow channel such that, during rotation of the drive shaft, a flow of fluid out of said outflow opening forms a fluid bearing between the rotating solid support element and the wall of the treated vessel.
Description
- This is a continuation of U.S. patent application Ser. No. 13/438,282 filed on Apr. 3, 2012, which is a continuation of U.S. patent application Ser. No. 12/373,461 filed on Jan. 12, 2009, which is a national phase application based on PCT/EP2007/056499 filed on Jun. 28, 2007, which claims priority to GB Patent Application No. 0613979.4 filed on Jul. 13, 2006. The contents of these prior applications are incorporated herein by reference.
- 1. Field
- The present invention provides a rotational atherectomy device for removing a stenotic lesion from within a vessel of a patient. More specifically, the invention relates to a rotational atherectomy device for removing or reducing stenotic lesions in blood vessels such as a human artery by rotating an abrasive element within the vessel to partially or completely ablate the unwanted material.
- 2. Description of Related Art
- Atherosclerosis, the clogging of arteries, is a leading cause of coronary heart disease. Blood flow through the peripheral arteries (e.g., carotid, femoral, renal, etc.), is similarly affected by the development of atherosclerotic blockages. A conventional method of removing or reducing blockages in blood vessels is known as rotational atherectomy. A long guidewire is advanced into the diseased blood vessel and across the stenotic lesion. A hollow drive shaft is then advanced over the guidewire. The distal end of the drive shaft terminates in a burr provided with an abrasive surface formed from diamond grit or diamond particles. The burr is positioned against the occlusion and the drive shaft rotated at extremely high speeds (e.g., 20,000-160,000 rpm). As the burr rotates, the physician slowly advances it so that the abrasive surface of the burr scrapes against the occluding tissue and disintegrates it, reducing the occlusion and improving the blood flow through the vessel. Such a method and a device for performing the method are described in, for example, U.S. Pat. No. 4,990,134 to Auth. It is also known from U.S. Pat. No. 6,132,444 to Shturman (the instant inventor) et al, to provide a drive shaft with an abrasive element eccentrically positioned proximally to and spaced away from the distal end of the drive shaft.
- Rotational angioplasty (atherectomy) is frequently used to remove atherosclerotic or other blocking material from stenotic (blocked) coronary arteries and other blood vessels. However, a disadvantage with this technique is that abraded particles can migrate along the blood vessel distally and block very small diameter vessels including capillaries of the heart muscle itself The effect of the particulate debris produced by this procedure is of major concern to physicians who practice in this field. Clearly, the existence of particulate matter in the blood stream is undesirable and can cause potentially life-threatening complications, especially if the particles are over a certain size.
- Although the potentially detrimental effect caused by the presence of abraded particles in the blood vessels is reduced if they are very small microparticles, it is much more preferable to remove from the treated blood vessel any debris abraded or otherwise released from the stenotic lesion during treatment and thereby prevent migration of debris to other locations along the treated blood vessel.
- A rotational atherectomy device, described in U.S. Pat. No. 5,681,336 (to Clement et al), has been proposed which attempts to prevent migration of abraded particles along the blood stream by removing the ablated material from the blood vessel whilst the device is in use. The rotational atherectomy device known from U.S. Pat. No. 5,681,336 (to Clement et al.) has a complicated construction and is difficult to manufacture on a commercial scale.
- A number of disadvantages associated with the known rotational atherectomy devices have been addressed in WO 2006/126076, WO 2006/126175 and WO 2006/126176 to Shturman (the instant inventor). The present invention seeks to further improve rotational atherectomy devices known from these documents and other disadvantages associated with known atherectomy devices.
- Two most preferred embodiments of the Rotational Atherectomy Device with Solid Support Elements are described in WO 2006/126076. Both embodiments comprise an abrasive element and a pair of solid support elements mounted to a hollow drive shaft formed from a torque transmitting coil and a fluid impermeable membrane. In both preferred embodiments, the abrasive element is located proximal to and spaced away from the distal end. The solid support elements described in WO 2006/126076 are rounded. One of them is located at the distal end of the drive shaft and is referred to as the distal solid support element. The other is located proximal to and spaced away from the abrasive element and is referred to as the proximal distal support element.
- In one embodiment of the invention described in WO 2006/126076, the abrasive element has its centre of mass spaced away from the longitudinal or rotational axis of the drive shaft. In that embodiment, both the distal and the proximal solid support elements also have their centres of mass spaced radially away from the longitudinal or rotational axis of the drive shaft, the centre of mass of each of the two solid support elements being located diametrically opposite to the centre of mass of the abrasive clement with respect to the longitudinal axis of the drive shaft so that the distal and proximal solid support elements act as counterweights with respect to the abrasive element when the drive shaft rotates. Most preferably, the distal and proximal solid support elements are located in the same longitudinal plane as the centre of mass of the abrasive element, the longitudinal plane extending through the longitudinal or rotational axis of the drive shaft.
- In another embodiment described in WO 2006/126076, the abrasive element and the solid support elements have their centres of mass coaxial with the longitudinal or rotational axis of the fluid impermeable drive shaft.
- In both embodiments described in WO 2006/126076, pressurised fluid enters treated vessel only through a distal end opening of the fluid impermeable lumen of the drive shaft.
- According to the invention, there is provided a rotational atherectomy device for removing a stenotic tissue from a vessel of a patient, the device comprising a rotatable, flexible, hollow drive shaft having a distal end, an abrasive element mounted to the drive shaft proximal to and spaced away from a distal solid support element mounted at the distal end of the drive shaft, the distal solid support element having a rounded outer surface and comprising an outflow channel extending through the solid distal support element, the outflow channel having an outflow opening in said rounded outer surface, the drive shaft comprising a torque transmitting coil and at least one fluid impermeable membrane forming a fluid impermeable lumen for the antegrade flow of fluid along the torque transmitting coil into the outflow channel of the solid distal support element such that, during rotation of the drive shaft, said outflow opening of the outflow channel is facing an inner surface of a vessel being treated so that a flow of fluid out of said outflow opening forms a layer of fluid between the solid distal support element and a wall of the treated vessel, said layer of fluid forming a fluid bearing between the rotating solid distal support element and the wall of the treated vessel.
- In a preferred embodiment, the fluid impermeable drive shaft is provided with a solid proximal support element located proximal to and spaced away from the abrasive element, the membrane that forms a fluid impermeable lumen for the antegrade flow of fluid along the torque transmitting coil into the outflow channel of the distal solid support element also forming a lumen for the antegrade flow of fluid along the torque transmitting coil into an outflow channel extending through said solid proximal support element, the solid proximal support element having a rounded outer surface, said outflow channel having an outflow opening in the rounded outer surface of the solid proximal support element such that, during rotation of the drive shaft, said outflow opening on the outer surface of the solid proximal support element is facing an inner surface of a treated vessel so that a flow of fluid out of said outflow opening forms a layer of fluid between the solid proximal support element and a wall of the treated vessel, said layer of fluid forming a fluid bearing between the rotating solid proximal support element and the wall of the treated vessel.
- In one embodiment, the drive shaft preferably has a longitudinal axis and the solid distal support element has a centre of mass which is coaxial with the longitudinal axis of the drive shaft, said distal support element having a plurality of outflow channels that extend through the distal support element in a radially outward direction with respect to the longitudinal axis of the drive shaft and have their outflow openings spaced around the circumference of the solid distal support element such that, during rotation of the drive shaft, a flow of fluid through the outflow openings forms a layer of fluid between the solid distal support element and a wall of the vessel being treated, said layer of fluid forming a fluid bearing between the rotating solid distal support element and the wall of the vessel being treated. In this embodiment, the centre of mass of the abrasive element may either be coaxial with the longitudinal axis of the drive shaft or, spaced radially away from the longitudinal axis of the drive shaft.
- In an embodiment where there is a solid proximal support element, the solid proximal support element may have a centre of mass coaxial with the longitudinal axis of the drive shaft, said proximal support element having a plurality of outflow channels extending through the solid proximal support element in a radially outward direction with respect to the longitudinal axis of the drive shaft and having their outflow openings located around the circumference of the solid proximal support element such that, during rotation of the drive shaft, a flow of fluid out of the outflow openings forms a layer of fluid between the solid proximal support element and a wall of the vessel being treated, said layer of fluid forming a fluid bearing between the rotating solid proximal support element and the wall of the vessel being treated. In this embodiment, the centre of mass of the abrasive element may either be coaxial with the longitudinal axis of the drive shaft or, spaced radially away from the longitudinal axis of the drive shaft.
- In one embodiment, the solid distal support element may have its centre of mass spaced radially away from the longitudinal axis of the drive shaft in one direction so that it acts as a counterweight to the abrasive element, which has its centre of mass spaced radially away from the longitudinal axis of the drive shaft in a diametrically opposite direction.
- In an embodiment in which the abrasive element has its centre of mass spaced radially away from a longitudinal axis of the drive shaft, the centres of mass of both distal and proximal solid support elements may be spaced radially away from a longitudinal axis of the drive shaft but in a direction diametrically opposite to the direction in which the abrasive element is spaced radially away from the longitudinal axis of the drive shaft so that the distal and proximal solid support elements act as counterweights to the abrasive element.
- It will be appreciated that there may be a plurality of outflow channels in the solid distal support element in any of the embodiments of the invention.
- It should be emphasized that the present invention covers two most preferred embodiments in one of which the solid support elements are asymmetrical with respect to the longitudinal axis of the drive shaft. In the other preferred embodiment, the solid support elements are symmetric with respect to the longitudinal axis of the drive shaft. However, it will be appreciated that, in all the embodiments, the asymmetric and symmetric solid support elements comprise outflow channels located such that, in the rotating drive shaft, fluid flowing out of said channels forms fluid bearings between outer walls of said solid support elements and the wall of the treated vessel.
- It should be noted that throughout this specification, reference is made to “distal” and “proximal” ends and to flow of fluid in an “antegrade” and “retrograde” direction. For the avoidance of doubt, the distal end is considered to refer to the end of the device which is inserted into the vessel in the body of the patient and the proximal end is the end of the device which remains outside the body of the patient and which can be connected to a handle assembly for both rotating and longitudinally moving the drive shaft within the treated vessel. “Antegrade” flow refers to a direction of flow from the proximal towards the distal end of the device. Similarly, “retrograde” flow refers to a direction of flow in the opposite direction, i.e. from the distal towards the proximal end of the device.
- Embodiments of the invention will now be described, by way of example only, and with reference to the accompanying drawings, in which:
-
FIG. 1 illustrates in a longitudinal cross-section a distal portion of one preferred embodiment of the rotational atherectomy device of the invention, this embodiment comprising asymmetric solid support elements and illustrating the location of outflow channels which extend through said solid support elements; -
FIG. 2 illustrates the device ofFIG. 1 located in a vessel being treated and shows how the device can be used to abrade a stenotic lesion while forming fluid bearings between rounded outer surfaces of asymmetric solid support elements located distal and proximal to the abrasive element; -
FIG. 3 illustrates in a longitudinal cross-section a distal portion of one preferred embodiment of the rotational atherectomy device of the invention, this embodiment comprising symmetric solid support elements located distal and proximal to the symmetric abrasive element and illustrates location of outflow channels which extend through said solid support elements; and -
FIG. 4 illustrates the device ofFIG. 3 located in a vessel being treated and shows how the device can be used to abrade a stenotic lesion in a curved vessel. This Figure also shows how fluid bearings are formed between the rounded outer surfaces of symmetric solid support elements and the wall of the treated vessel. - In
FIGS. 1 to 4 , the antegrade flow of fluid is indicated by arrows “FF” and the flow of fluid in a retrograde direction is indicated by arrows marked “R”. Abraded particles AP abraded from thestenotic lesion 330 are aspirated into a lumen of adrive shaft sheath 400 so that the retrograde flowing fluid and the abraded particles entrained in said fluid can be removed from the treated vessel and out of the patient's body. - Referring to the drawings, there is shown a rotational atherectomy device for removing a stenotic lesion from within a vessel of a patient using an abrasive element mounted to a rotatable, flexible, hollow drive shaft formed by a torque transmitting coil and a fluid impermeable membrane. The drive shaft has a longitudinal axis of rotation and is provided with two rounded solid support elements. Each of the two solid support elements is spaced away from the abrasive element and includes at least one outflow channel which is directed radially outward and communicates a lumen of the drive shaft with a vascular space of the treated vessel, one of said solid support elements is a distal solid support element and is located at a distal end of the drive shaft and the other is a proximal solid support element and is located proximal to the abrasive element.
- In a preferred embodiment, each of the distal and proximal solid support elements has a rounded surface and is spaced equally from the abrasive element which extends around the entire circumference of the drive shaft.
- In one embodiment of the invention the abrasive element and each of the two solid support elements are symmetric with respect to the rotational (longitudinal) axis of the drive shaft. In another embodiment of the invention the abrasive element and the solid support elements have their centres of mass spaced radially away from the rotational (longitudinal) axis of the drive shaft.
- Each outflow channel has its own axis and each of the solid support elements has at least one outflow channel located such that its axis comprises an acute angle of at least seventy five (75) degrees with the longitudinal (rotational) axis of the drive shaft. In a preferred embodiment each of the solid support elements has at least one outflow channel located such that its axis comprises an angle of about (90) degrees with the longitudinal (rotational) axis of the drive shaft. In the most preferred embodiment of the invention each of the symmetric solid support elements has at least a few outflow channels equally spaced around the maximum circumference of the support element, each of said outflow channels having an axis which comprises an angle of about ninety (90) degrees with the longitudinal (rotational) axis of the drive shaft. In any of the preferred embodiments of the invention at least one outflow channel is located such that in a rotating drive shaft fluid which flows through the outflow channel along its axis forms at least a thin layer of fluid between the solid support element and the wall of the treated vessel.
-
FIG. 1 illustrates, in a longitudinal cross-section, a distal portion of one preferred embodiment of the rotational atherectomy device of an embodiment of the invention. The rotational atherectomy device is comprised of an asymmetricabrasive element 101 which extends around the entire circumference of thedrive shaft 2 proximal to and spaced away from adistal end 6 of the drive shaft. The fluidimpermeable drive shaft 2 is comprised by a fluidimpermeable membrane 3 which lines a torque transmitting coil 4. Both the torque transmitting coil 4 and the fluidimpermeable membrane 3 extend distally beyond theabrasive element 101. -
FIG. 1 illustrates an asymmetricdistal support element 10 which has its centre of mass spaced radially away from the longitudinal (rotational) axis W-W of thedrive shaft 2. The Figure illustrates that at least oneoutflow channel 20 which extends through aheavier portion 60 of the asymmetricdistal support element 10, the axis K-K of theoutflow channel 20 comprises an acute angle a of about ninety (90) degrees with the longitudinal (rotational) axis W-W of the drive shaft. However, it will be appreciated that there may be a plurality ofoutflow channels 20 and the axes of these channels may form an acute angle of up to 30 degrees with axis K-K of the most important outflow channel. Its axis K-K being oriented perpendicular to the longitudinal axis of the drive shaft. In the most preferred embodiment of the invention, axis K-K of at least oneoutflow channel 20 passes through or close to the centre of mass of the asymmetric distal solid support element. -
FIGS. 1 and 2 illustrate that a portion of flushing fluid FF flowing in an antegrade direction through thedrive shaft 2 is redirected through theoutflow channel 20 into a vascular space of the treated vessel. -
FIG. 2 illustrates that in a rotating drive shaft centrifugal force attempts to press a rotating asymmetric soliddistal support element 10 against thewall 300 of the treated vessel but fluid exiting through theoutflow channel 20 along its axis K-K and forms an acute angle β of over 75 degrees with an inner surface of awall 300 of the treated vessel so that fluid flowing through theoutflow channel 20 forms a thin layer of fluid between thesolid support element 10 and an inner surface of the treated vessel. This thin layer of fluid acts as a fluid bearing between the asymmetric distalsolid support element 10 and awall 300 of the treated vessel. At least a portion of fluid flowing through theoutflow channel 20 flows in a retrograde direction, as indicated by arrows marked “R”, and entrains abraded particles AP removed from thestenotic lesion 330. The retrograde flowing flushing fluid R and entrained abraded particles AP are aspirated into a lumen of thedrive shaft sheath 400. -
FIG. 1 illustrates an asymmetricproximal support element 10 p which has its centre of mass spaced radially away from the longitudinal (rotational) axis W-W of thedrive shaft 2. The Figure illustrates that at least oneoutflow channel 20 p extends through aheavier portion 60 p of the asymmetricproximal support element 10 p. Theoutflow channel 20 p has an axis L-L which forms an acute angle a of about ninety (90) degrees with the longitudinal (rotational) axis W-W of the drive shaft. However, it will be appreciated that there may be a plurality ofoutflow channels 20 p and the axes of these channels may form an acute angle of up to 30 degrees with axis L-L of the most important outflow channel that has its axis L-L oriented perpendicular to the longitudinal axis of the drive shaft. -
FIGS. 1 and 2 illustrate that a portion of flushing fluid FF flowing in an antegrade direction through thedrive shaft 2 is redirected through theoutflow channel 20 p into a vascular space of the treated vessel. -
FIG. 2 illustrates that in a rotating drive shaft centrifugal force attempts to press a rotating asymmetric solidproximal support element 10 p against thewall 300 of the treated vessel but fluid exiting through theoutflow channel 20 p along its axis L-L forms an angle β of about ninety (90) degrees with an inner surface of awall 300 of the treated vessel so that fluid flowing through theoutflow channel 20 p forms a thin layer of fluid between thesolid support element 10 p and an inner surface of the treated vessel. This thin layer of fluid acts as a fluid beating between the asymmetric distalsolid support element 10 p and awall 300 of the treated vessel. -
FIG. 3 illustrates a symmetricdistal support element 10 s. The centre of mass of the symmetricdistal support element 10 s coincides with the longitudinal (rotational) axis W-W of thedrive shaft 2. In a preferred embodiment of the invention at least afew outflow channels 20 s should extend radially outward through the symmetricdistal support element 10 s communicating a fluid impermeable lumen of thedrive shaft 2 with a vascular space of the treated vessel. Preferably saidoutflow channels 20 s should be equally spaced around the maximum diameter circumference of the symmetric distalsolid support element 20 s.FIG. 3 illustrates that an axis M-M of at least oneoutflow channel 20 s comprises an acute angle of over seventy five (75) degrees with the longitudinal (rotational) axis W-W of thedrive shaft 2. In the preferred embodiment axis M-M of theoutflow channel 20 s forms an angle a of about ninety (90) degrees with the longitudinal (rotational) axis W-W of the drive shaft. -
FIGS. 3 and 4 illustrate that a portion of flushing fluid FF flowing in an antegrade direction through thedrive shaft 2 is redirected through theoutflow channels 20 s into a vascular space of the treated vessel. -
FIG. 4 illustrates that, in a curved vessel, thedrive shaft 2 attempts to maintain its straight configuration and therefore attempts to press both of the solid symmetric support elements towards the outer curvature of the vessel and the symmetricabrasive element 102 towards the inner curvature of the vessel. -
FIG. 4 illustrates that in a rotating drive shaft the axis M-M of theoutflow channel 20 s forms an angle β of about ninety (90) degrees with an inner surface of awall 300 of the treated vessel so that fluid flowing through theoutflow channel 20 s along its axis M-M forms a thin layer of fluid between thesolid support element 10 s and an inner surface of the treated vessel. This thin layer of fluid acts as a fluid bearing between thesolid support element 10 s and awall 300 of the treated vessel. At least a portion of the fluid flowing through theoutflow channels 20 is flowing in a retrograde direction R and entrains abraded particles AP removed (abraded) by the symmetricabrasive element 102 from thestenotic lesion 360 located on the inner curvature of thevessel 300. The retrograde flowing flushing fluid R is aspirated into a lumen of thedrive shaft sheath 400. -
FIG. 3 illustrates a symmetricproximal support element 10 sp. The centre of mass of the symmetricproximal support element 10 sp coincides with the longitudinal (rotational) axis of thedrive shaft 2. In a preferred embodiment of the invention at least afew outflow channels 20 spshould extend radially outward through the symmetricproximal support element 10 spcommunicating a fluid impermeable lumen of thedrive shaft 2 with a vascular space of the treated vessel. Preferably saidoutflow channels 20 sp should be equally spaced around the maximum diameter circumference of the symmetric distalsolid support element 20 sp.FIG. 3 illustrates that an axis N-N of at least oneoutflow channel 20 sp comprises an acute angle of at least seventy five (75) degrees with the longitudinal (rotational) axis W-W of thedrive shaft 2. In the preferred embodiment axis N-N of theoutflow channels 20 sp forms an angle a of about ninety (90) degrees with the longitudinal (rotational) axis W-W of the drive shaft.FIGS. 3 and 4 illustrate that a portion of flushing fluid FF flowing in an antegrade direction through thedrive shaft 2 is redirected through theoutflow channel 20 sp into a vascular space of the treated vessel. -
FIG. 4 illustrates that in a rotating drive shaft the axis N-N of theoutflow channel 20 sp forms an angle β of about ninety (90) degrees with an inner surface of awall 300 of the treated vessel so that fluid flowing through theoutflow channel 20 sp along its axis N-N forms a thin layer of fluid between the proximalsolid support element 10 sp and an inner surface of the treated vessel. This thin layer of fluid acts as a fluid bearing between the proximalsolid support element 10 spand awall 300 of the treated vessel. -
FIG. 3 illustrates an embodiment in which a fluid impermeable membrane lines the torque transmitting coil. In an alternative embodiment, illustrated inFIG. 4 , the fluid impermeable membrane is disposed around the torque transmitting coil. - It will be appreciated that the device with symmetric support elements is not intended to be exclusively used in curved vessels but can also be used successfully in straight vessels.
- Many modifications and variations of the invention falling within the terms of the following claims will be apparent to a person skilled in the art and the foregoing description should be regarded as a description of the preferred embodiments only.
Claims (12)
1. A method of using a rotational atherectomy device comprising:
delivering a distal end portion of a rotational atherectomy device to a blood vessel having a stenotic lesion to be treated, the rotational atherectomy device including a rotatable, flexible drive shaft comprising a longitudinal axis, a torque transmitting coil, and at least one fluid delivery lumen extending to the distal end portion of rotational atherectomy device;
rotating the drive shaft of the rotational atherectomy device so that an abrasive element mounted to the drive shaft along distal end portion of the rotational atherectomy device rotates with the vessel having the stenotic lesion to be treated, wherein a center of mass of the abrasive element is offset from the longitudinal axis of the drive shaft; and
during rotation of the drive shaft, outputting fluid flow in a generally radially outward direction through outflow ports in each of a distal solid counterweight and a proximal solid counterweight mounted to the drive shaft along distal end portion of the rotational atherectomy device, the abrasive element being positioned proximal to and spaced away from the distal solid counterweight located at a distal tip of the drive shaft, and the abrasive element being positioned distal to and spaced away from the proximal solid counterweight, each of the distal and proximal solid support elements being substantially smaller than the abrasive element and having a surface texture that is different from an abrasive surface texture of the abrasive element, wherein said distal and proximal solid counterweights are configured to acts as counterweights to the abrasive element when said abrasive element and said distal and proximal solid counterweights rotate together with the drive shaft.
2. The method of claim 1 , further comprising contacting the abrasive element of the rotational atherectomy device with the stenotic lesion in the blood vessel during rotation of the drive shaft together with the abrasive element and the distal and proximal solid counterweights.
3. The method of claim 2 , further comprising aspirating into a lumen of a drive shaft sheath abraded particles entrained in a retrograde fluid flow after said particles are removed from the stenotic lesion.
4. The method of claim 1 , wherein each of the outflow ports is in fluid communication with the fluid delivery lumen of the drive shaft, and said step of outputting fluid flow in a generally radially outward direction through the outflow ports comprises delivering the fluid through the fluid delivery lumen of the drive shaft and to the distal solid counterweight and the proximal solid counterweight.
5. The method of claim 1 , wherein each of the distal and proximal solid counterweights has a rounded outer surface that is different from an outer surface of the abrasive element.
6. The method of claim 1 , wherein the outflow port of the distal solid counterweight and the outflow port of the proximal solid counterweight have axes that are generally orthogonal to the longitudinal axis of the drive shaft.
7. The method of claim 1 , wherein the fluid delivery lumen includes a fluid impermeable membrane that is positioned radially inward of the torque transmitting coil of the drive shaft.
8. The method of claim 7 , wherein the fluid impermeable membrane lines the torque transmitting coil.
9. The method of claim 1 , wherein the fluid delivery lumen includes a fluid impermeable membrane that is positioned radially outward of the torque transmitting coil of the drive shaft.
10. The method of claim 9 , wherein the fluid impermeable membrane lines the torque transmitting coil.
11. The method of claim 1 , wherein each of the distal and proximal solid counterweights has multiple outflow ports which are in fluid communication with the fluid delivery lumen of the drive shaft and which extend in radially outward directions with respect to the longitudinal axis of the drive shaft.
12. The method of claim 1 , wherein the fluid delivery lumen of the drive shaft is configured for advancement of the drive shaft over a guidewire across the stenotic lesion to be treated and for transfer of pressurized fluid into the outflow ports of the distal solid counterweight and the proximal solid counterweight after crossing the stenotic lesion.
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US13/875,632 US20130245654A1 (en) | 2006-07-13 | 2013-05-02 | Atherectomy device supported by fluid bearings |
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US37346109A | 2009-01-12 | 2009-01-12 | |
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US13/875,632 US20130245654A1 (en) | 2006-07-13 | 2013-05-02 | Atherectomy device supported by fluid bearings |
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US13/875,632 Abandoned US20130245654A1 (en) | 2006-07-13 | 2013-05-02 | Atherectomy device supported by fluid bearings |
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US13/438,282 Expired - Fee Related US8454638B2 (en) | 2006-07-13 | 2012-04-03 | Atherectomy device supported by fluid bearings |
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Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8936589B2 (en) | 2006-11-23 | 2015-01-20 | Cardio Flow Inc. | Rotational atherectomy device with fluid inflatable support elements and distal protection capability |
US9211138B2 (en) | 2009-04-03 | 2015-12-15 | Cardio Flow, Inc. | Rotational atherectomy device with distal embolic protection |
WO2016108860A1 (en) * | 2014-12-30 | 2016-07-07 | Bard Peripheral Vascular | Abrasive elements for rotational atherectorm systems |
US9788853B2 (en) | 2014-01-15 | 2017-10-17 | Cardio Flow, Inc. | Atherectomy devices and methods |
WO2017176904A3 (en) * | 2016-04-06 | 2017-11-16 | Cardio Flow, Inc. | Atherectomy devices and methods |
US10335187B2 (en) | 2017-02-23 | 2019-07-02 | Cardio Flow, Inc. | Atherectomy devices and methods |
US10405879B2 (en) | 2014-12-04 | 2019-09-10 | Boston Scientific Scimed, Inc. | Rotatable medical device |
US10405878B2 (en) | 2014-07-25 | 2019-09-10 | Boston Scientific Scimed, Inc. | Rotatable medical device |
US10463390B1 (en) | 2018-05-24 | 2019-11-05 | Cardio Flow, Inc. | Atherectomy devices and methods |
US10524826B1 (en) | 2018-06-14 | 2020-01-07 | Cardio Flow, Inc. | Atherectomy devices and methods |
US11272954B2 (en) | 2018-08-07 | 2022-03-15 | Cardio Flow, Inc. | Atherectomy devices and methods |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0613982D0 (en) | 2006-07-13 | 2006-08-23 | Shturman Leonid | Rotational atherectomy device with fluid inflatable support elements and two torque transmitting coils |
GB0613981D0 (en) * | 2006-07-13 | 2006-08-23 | Shturman Leonid | |
GB0613980D0 (en) | 2006-07-13 | 2006-08-23 | Shturman Leonid | Rotational Atherectomy Device with Fluid Inflatable Elements supported by Fluid Bearings |
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GB0722990D0 (en) | 2007-11-23 | 2008-01-02 | Shturman Leonid | Rotational atherectomy system with enhanced distal protection capability and method of use |
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US20120046600A1 (en) * | 2010-02-25 | 2012-02-23 | Cardiovascular Systems, Inc. | High-speed rotational atherectomy system, device and method for localized application of therapeutic agents to a biological conduit |
US9629646B2 (en) | 2012-07-11 | 2017-04-25 | Jens Kather | Curved burr surgical instrument |
US9289230B2 (en) | 2012-09-17 | 2016-03-22 | Cardiovascular Systems, Inc. | Rotational atherectomy device with a system of eccentric abrading heads |
US10517631B2 (en) | 2012-09-17 | 2019-12-31 | Cardiovascular Systems, Inc. | Rotational atherectomy device with a system of eccentric abrading heads |
US9936970B2 (en) | 2013-03-14 | 2018-04-10 | Cardiovascular Systems, Inc. | Devices, systems and methods for an oscillating crown drive for rotational atherectomy |
US9750525B2 (en) | 2013-03-14 | 2017-09-05 | Cardiovascular Systems, Inc. | Devices, systems and methods for an oscillating crown drive for rotational atherectomy |
CN105395238B (en) * | 2015-12-14 | 2017-10-10 | 天津大学 | A kind of plaque within blood vessels remove device |
SG11201807481UA (en) * | 2016-03-21 | 2018-09-27 | Cardivascular Systems | Rotational atherectomy device with a system of eccentric abrading heads |
US11690645B2 (en) | 2017-05-03 | 2023-07-04 | Medtronic Vascular, Inc. | Tissue-removing catheter |
CN114948106A (en) | 2017-05-03 | 2022-08-30 | 美敦力瓦斯科尔勒公司 | Tissue removal catheter with guidewire isolation bushing |
US11819236B2 (en) | 2019-05-17 | 2023-11-21 | Medtronic Vascular, Inc. | Tissue-removing catheter |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4990134A (en) * | 1986-01-06 | 1991-02-05 | Heart Technology, Inc. | Transluminal microdissection device |
US5584843A (en) * | 1994-12-20 | 1996-12-17 | Boston Scientific Corporation | Shaped wire multi-burr rotational ablation device |
US5681336A (en) * | 1995-09-07 | 1997-10-28 | Boston Scientific Corporation | Therapeutic device for treating vien graft lesions |
US20020007190A1 (en) * | 2000-04-05 | 2002-01-17 | Wulfman Edward I. | Intralumenal material removal systems and methods |
US8157825B2 (en) * | 2006-07-13 | 2012-04-17 | Lela Nadirashvili | Atherectomy device supported by fluid bearings |
US8353923B2 (en) * | 2005-05-26 | 2013-01-15 | Cardiovascular Systems, Inc. | Rotational device with eccentric abrasive element and method of use |
Family Cites Families (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1431461A (en) * | 1921-11-07 | 1922-10-10 | Gen Electric | Combined car-door control and air-brake equipment |
US1431416A (en) | 1922-06-01 | 1922-10-10 | Ingersoll Rand Co | Built-up crank shaft |
US1916085A (en) * | 1927-06-24 | 1933-06-27 | Packard Motor Car Co | Counterweight |
US4646736A (en) * | 1984-09-10 | 1987-03-03 | E. R. Squibb & Sons, Inc. | Transluminal thrombectomy apparatus |
US4870953A (en) * | 1987-11-13 | 1989-10-03 | Donmicheal T Anthony | Intravascular ultrasonic catheter/probe and method for treating intravascular blockage |
US4931635A (en) * | 1987-12-01 | 1990-06-05 | Teijin Seiki Company Limited | Optical position sensor using Faraday effect element and magnetic scale |
US4940238A (en) * | 1988-01-25 | 1990-07-10 | Bradley Robert J | Golf putting practice ball and system |
DE69015926T2 (en) * | 1989-08-25 | 1995-05-18 | Scimed Life Systems Inc | Device for changing a catheter while holding the guide wire. |
US5100425A (en) | 1989-09-14 | 1992-03-31 | Medintec R&D Limited Partnership | Expandable transluminal atherectomy catheter system and method for the treatment of arterial stenoses |
US5242460A (en) * | 1990-10-25 | 1993-09-07 | Devices For Vascular Intervention, Inc. | Atherectomy catheter having axially-disposed cutting edge |
US5273526A (en) * | 1991-06-21 | 1993-12-28 | Lake Region Manufacturing Company, Inc. | Vascular occulusion removal devices and method |
US5217474A (en) * | 1991-07-15 | 1993-06-08 | Zacca Nadim M | Expandable tip atherectomy method and apparatus |
DE69224911T2 (en) * | 1991-11-04 | 1998-12-03 | Baxter Int | ULTRASONIC DEVICE FOR ABLATION WITH CHANNEL FOR GUIDE WIRE |
US5250060A (en) * | 1992-06-26 | 1993-10-05 | Carbo Paul L | Angioplasty apparatus |
US5360432A (en) * | 1992-10-16 | 1994-11-01 | Shturman Cardiology Systems, Inc. | Abrasive drive shaft device for directional rotational atherectomy |
US5403280A (en) * | 1993-02-16 | 1995-04-04 | Wang; James C. | Inflatable perfusion catheter |
US5317607A (en) * | 1993-04-30 | 1994-05-31 | Combustion Engineering, Inc. | EDM crack removal tooling |
US5370653A (en) * | 1993-07-22 | 1994-12-06 | Micro Therapeutics, Inc. | Thrombectomy method and apparatus |
WO1996004862A1 (en) * | 1994-08-12 | 1996-02-22 | U.S. Synthetic | Prosthetic joint with diamond coated interfaces |
US6905505B2 (en) * | 1996-07-26 | 2005-06-14 | Kensey Nash Corporation | System and method of use for agent delivery and revascularizing of grafts and vessels |
US5843103A (en) * | 1997-03-06 | 1998-12-01 | Scimed Life Systems, Inc. | Shaped wire rotational atherectomy device |
US6015420A (en) * | 1997-03-06 | 2000-01-18 | Scimed Life Systems, Inc. | Atherectomy device for reducing damage to vessels and/or in-vivo stents |
US5868708A (en) * | 1997-05-07 | 1999-02-09 | Applied Medical Resources Corporation | Balloon catheter apparatus and method |
US6132444A (en) * | 1997-08-14 | 2000-10-17 | Shturman Cardiology Systems, Inc. | Eccentric drive shaft for atherectomy device and method for manufacture |
US5928193A (en) * | 1997-10-03 | 1999-07-27 | Boston Scientific Corporation | Balloon catheterization |
US6146395A (en) * | 1998-03-05 | 2000-11-14 | Scimed Life Systems, Inc. | Ablation burr |
US6096054A (en) * | 1998-03-05 | 2000-08-01 | Scimed Life Systems, Inc. | Expandable atherectomy burr and method of ablating an occlusion from a patient's blood vessel |
US6152911A (en) * | 1998-08-27 | 2000-11-28 | Chase Medical, Inc. | Venous return catheter having multiple helical support members |
US6955661B1 (en) * | 1999-01-25 | 2005-10-18 | Atrium Medical Corporation | Expandable fluoropolymer device for delivery of therapeutic agents and method of making |
US6241706B1 (en) * | 1999-07-16 | 2001-06-05 | Datascope Investment Corporation | Fast response intra-aortic balloon pump |
US6350253B1 (en) * | 1999-07-19 | 2002-02-26 | I-Flow Corporation | Catheter for uniform delivery of medication |
US6663613B1 (en) * | 2000-01-25 | 2003-12-16 | Bacchus Vascular, Inc. | System and methods for clot dissolution |
US6485500B1 (en) * | 2000-03-21 | 2002-11-26 | Advanced Cardiovascular Systems, Inc. | Emboli protection system |
AU2001276954A1 (en) | 2000-07-31 | 2002-02-13 | Boston Scientific Limited | Expandable atherectomy burr |
US6491660B2 (en) * | 2001-01-23 | 2002-12-10 | Scimed Life Systems, Inc. | Frontal infusion system for intravenous burrs |
US20040098014A1 (en) * | 2001-03-30 | 2004-05-20 | Moshe Flugelman | Inflatable medical device with combination cutting elements and drug delivery conduits |
US7666202B2 (en) * | 2004-01-07 | 2010-02-23 | Cardiovascular Systems, Inc. | Orbital atherectomy device guide wire design |
US7959608B2 (en) * | 2004-04-27 | 2011-06-14 | The Spectranetics Corporation | Thrombectomy and soft debris removal device |
US7347853B2 (en) * | 2004-05-12 | 2008-03-25 | C. R. Bard, Inc. | Catheter with removable extension |
GB2426458A (en) * | 2005-05-26 | 2006-11-29 | Leonid Shturman | Atherectomy device |
GB2426455A (en) | 2005-05-26 | 2006-11-29 | Leonid Shturman | A rotational atherectomy device with supports on the drive shaft |
-
2006
- 2006-07-13 GB GBGB0613979.4A patent/GB0613979D0/en not_active Ceased
-
2007
- 2007-06-28 WO PCT/EP2007/056499 patent/WO2008006704A1/en active Application Filing
- 2007-06-28 CA CA2648819A patent/CA2648819C/en not_active Expired - Fee Related
- 2007-06-28 EP EP07765711.2A patent/EP2040625B1/en not_active Not-in-force
- 2007-06-28 US US12/373,461 patent/US8157825B2/en active Active
- 2007-06-28 GB GB0712601A patent/GB2440223A/en not_active Withdrawn
- 2007-06-28 AU AU2007271819A patent/AU2007271819A1/en not_active Abandoned
-
2012
- 2012-04-03 US US13/438,282 patent/US8454638B2/en not_active Expired - Fee Related
-
2013
- 2013-05-02 US US13/875,632 patent/US20130245654A1/en not_active Abandoned
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4990134A (en) * | 1986-01-06 | 1991-02-05 | Heart Technology, Inc. | Transluminal microdissection device |
US4990134B1 (en) * | 1986-01-06 | 1996-11-05 | Heart Techn Inc | Transluminal microdissection device |
US5584843A (en) * | 1994-12-20 | 1996-12-17 | Boston Scientific Corporation | Shaped wire multi-burr rotational ablation device |
US5681336A (en) * | 1995-09-07 | 1997-10-28 | Boston Scientific Corporation | Therapeutic device for treating vien graft lesions |
US20020007190A1 (en) * | 2000-04-05 | 2002-01-17 | Wulfman Edward I. | Intralumenal material removal systems and methods |
US8353923B2 (en) * | 2005-05-26 | 2013-01-15 | Cardiovascular Systems, Inc. | Rotational device with eccentric abrasive element and method of use |
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Also Published As
Publication number | Publication date |
---|---|
AU2007271819A1 (en) | 2008-01-17 |
GB0613979D0 (en) | 2006-08-23 |
GB0712601D0 (en) | 2007-08-08 |
EP2040625A1 (en) | 2009-04-01 |
US20090312777A1 (en) | 2009-12-17 |
US20120191113A1 (en) | 2012-07-26 |
US8454638B2 (en) | 2013-06-04 |
GB2440223A (en) | 2008-01-23 |
CA2648819A1 (en) | 2008-01-17 |
US8157825B2 (en) | 2012-04-17 |
EP2040625B1 (en) | 2016-08-10 |
WO2008006704A1 (en) | 2008-01-17 |
CA2648819C (en) | 2011-10-04 |
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