US20110213387A1 - Minimally Invasive Valve Repair Procedure and Apparatus - Google Patents

Minimally Invasive Valve Repair Procedure and Apparatus Download PDF

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Publication number
US20110213387A1
US20110213387A1 US13/038,676 US201113038676A US2011213387A1 US 20110213387 A1 US20110213387 A1 US 20110213387A1 US 201113038676 A US201113038676 A US 201113038676A US 2011213387 A1 US2011213387 A1 US 2011213387A1
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United States
Prior art keywords
clip
needle
flexible member
leaflets
minimally invasive
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Abandoned
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US13/038,676
Inventor
John D. Nguyen
Laurent Schaller
Art Hill
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Medtronic Inc
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Medtronic Inc
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Priority to US13/038,676 priority Critical patent/US20110213387A1/en
Publication of US20110213387A1 publication Critical patent/US20110213387A1/en
Abandoned legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/064Surgical staples, i.e. penetrating the tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/0469Suturing instruments for use in minimally invasive surgery, e.g. endoscopic surgery
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/06Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/0469Suturing instruments for use in minimally invasive surgery, e.g. endoscopic surgery
    • A61B2017/0472Multiple-needled, e.g. double-needled, instruments
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/06Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
    • A61B17/06004Means for attaching suture to needle
    • A61B2017/06009Means for attaching suture to needle having additional means for releasably clamping the suture to the needle, e.g. actuating rod slideable within the needle
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/06Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
    • A61B2017/06057Double-armed sutures, i.e. sutures having a needle attached to each end
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/08Wound clamps or clips, i.e. not or only partly penetrating the tissue ; Devices for bringing together the edges of a wound
    • A61B2017/081Tissue approximator
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/24Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2442Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve

Definitions

  • This invention relates to methods and apparatus for minimally invasive valve repair and more particularly to minimally invasive methods and apparatus for reducing the valve orifice.
  • Valve repair is currently done in open surgical procedures as described, for example, by F. Maisano, et al. in their article entitled “The double-orifice technique as a standardized approach to treat mitral regurgitation due to severe myxomatous disease” which appeared in European Journal of Cardio-thoracic Surgery, Vol. 17 (2000) 201-205. Cumbersome suture management, knot tying, pain and long recovery time are inherent to such open surgical procedures. It now goes without saying that minimally invasive surgery is the preferred procedure, having allowed surgeons to perform procedures with less pain and disability than open surgical procedures. Tissue-connector apparatus and methods usable in such minimally invasive surgery procedures have recently been disclosed in U.S. patent applications Ser. Nos. 09/089,884 and 09/090,305 both filed Jun. 3, 1998 and Ser. Nos. 09/259,705 and 09/260,623 both filed Mar. 1, 2000.
  • a clip of a self-closing type as a tissue connector to capture leaflets and secure them together.
  • a clip is typically U-shaped, having two end points, when it is constrained to be in an open configuration but is made of a wire of a shape memory material such that it tends to coil up to assume its natural closed configuration.
  • Such a clip may be deployed in the form of a clip assembly, having at least one of the end points of the clip connected to a tissue-piecing needle through a flexible member such as a suture and a release mechanism by which the clip can be easily released.
  • the needle is attached to the front end of a needle-holder and passed through a cannula inserted through an incision towards the valve leaflets to be repaired.
  • the needle-holder is formed with an outer tube and an inner member which is slidable inside the outer tube and is designed such that as the inner member is pushed forward against the biasing force of a spring contained in the outer tube, a slit which is provided at the front end becomes wider for accepting the needle therein but as the inner member is allowed to move to a backward position, the slit becomes narrower and grips the needle tightly.
  • FIG. 1 is a schematic view of a tissue-connector apparatus embodying this invention when it is about to be used, its double-arm clip assembly being shown as a diagonal view and its needle holder being shown as a sectional side view;
  • FIG. 2 is an enlarged external view of the double-arm clip assembly of FIG. 1 ;
  • FIG. 3 is an enlarged sectional view of a portion of the needle holder near its front end
  • FIG. 4A is a schematic diagonal view of the clip assembly of FIGS. 1 and 2 being used in a valve repair procedure embodying this invention
  • FIG. 4B is another schematic diagonal view of the clip of FIG. 4A after it has been released;
  • FIG. 5 is an external view of a single-arm clip assembly which may be used in a method of minimally invasive valve repair embodying this invention
  • FIG. 6 is a schematic sectional view for showing a method of valve repair embodying this invention by using the single-arm clip assembly of FIG. 5 ;
  • FIG. 7 is another clip assembly embodying this invention.
  • FIG. 8A is a schematic sectional view of leaflets repaired by a clip assembly of FIG. 7
  • FIG. 8B is a top view of the leaflets of FIG. 8A
  • FIG. 8C is a top view of leaflets repaired in an alternative manner.
  • FIG. 1 shows schematically a tissue-connector apparatus 10 embodying this invention for a minimally invasive procedure. Described briefly, the apparatus 10 consists of a clip assembly 20 and a needle holder 30 , which will be described next sequentially in detail.
  • the clip assembly 20 may be referred to as the double-arm clip assembly, characterized as having a clip 22 of a self-closing type with two end points each connected through a flexible member 24 such as a suture to a tissue penetrating needle 25 (as disclosed, for example, in aforementioned U.S. patent applications Ser. Nos. 09/259,705 and 09/260,623 both filed Mar. 1, 2000, both of which are herein incorporated by reference).
  • Each of the needles 25 has a tissue-piercing sharp point and is connected to a corresponding one of the flexible members 24 .
  • the two end points of the clip 22 are each provided with and directly connected to a release mechanism 23 such that it can be released easily from the flexible members 24 and from being constrained to remain in its generally U-shaped open configuration.
  • the clip 22 or a surgical fastener, of the so-called self-closing type may be one disclosed in aforementioned U.S. patent applications Ser. Nos. 09/089,884 and 09/090,305 both filed Jun. 3, 1998 (herein also incorporated by reference), as well as in aforementioned U.S. patent applications Ser. Nos. 09/259,705 and 09/260,623, characterized as having two end points, being generally U-shaped when in an open configuration (as shown in FIGS.
  • such a clip 22 may comprise a deformable wire made of a shape memory alloy such as a nickel titanium based alloy (nitinol). It is also known that the alloy may include additional elements, depending on the desired yield strength of the material or the temperature at which particular pseudoelastic or shape transformation characteristics occur.
  • the clip 22 When the clip 22 is in its closed configuration (not shown) with no external restraining force thereupon, it may be in a completely closed loop with its end points in a side-by-side or overlapping orientation, the wire being looped by more than 360°.
  • the diameter of the wire for the clip 22 and the diameter of the loop when it is in the closed configuration may be selected, depending on the application, and do not limit the scope of the invention.
  • the needle holder 30 consists essentially of a hollow outer tube 32 , an inner member 34 and a spring 38 , as shown in FIG. 1 .
  • the outer tube 32 is elongated, defining a longitudinal direction.
  • the inner member 34 is also longitudinally elongated and is adapted to slide longitudinally inside the outer tube 32 and to releasably grab the needles 25 , one at a time.
  • the inner member 34 is comprised of a knob 341 at its proximal end, a conjunction tube 342 in the middle and a needle-holding tube 343 in front.
  • the conjunction tube 342 and the needle holding tube 343 are laser-welded together.
  • a threaded adapter is laser-welded to the proximal end of the conjunction tube 342 for allowing the knob 341 to be screwed thereonto after the spring 38 is inserted inside the outer tube 32 such that, once the needle holder 30 is thus assembled, the knob 341 , the conjunction tube 342 and the needle-holding tube 343 will move together as a single unit.
  • the front end of the needle-holding tube 343 is provided with a longitudinally elongated slit 35 for holding the needle 25 , and the outer tube 32 has a front opening 33 , as shown more clearly in FIG. 3 .
  • the needle-holding tube 343 with the slit 35 and the front opening 33 of the outer tube 32 are so designed that the slit 35 will open and become sufficiently wide in front as the inner member 34 is pushed forward through the outer tube 32 for accepting a needle 25 (shown by broken lines in FIG. 3 ) therein and that the opening of the slit 35 tends to become smaller as the inner member 34 is moved backwards through the outer tube 32 so as to retract the needle-holding tube 343 through the front opening 33 of the outer tube 32 , causing the needle-holding tube 343 to securely grab the needle 25 once accepted.
  • the spring 38 is disposed inside the outer tube 32 so as to provide a backward biasing force on the inner member 34 .
  • the inner member 34 is normally in a backward position inside the outer tube 32 under the influence of the backward biasing force of the spring 38 thereon.
  • the front part of the needle-holding tube 343 protrudes farther outward from the front opening 33 of the outer tube 32 and the slit 35 opens wider, its front opening becoming wide enough to accept the back part of a needle (away from its tissue-piercing sharp point).
  • the backward biasing force by the spring pushes the inner member 34 backward, reducing the length of the needle-holding tube 343 outside the front opening 33 of the outer tube 32 .
  • This has the effect of reducing the opening of the slit 35 and hence of having the needle 25 firmly gripped by the needle holder 30 .
  • the user pushes the knob 341 forward to accept the needle 25 and releases the force on the knob 341 to firmly grab it.
  • the user has only to push the knob 341 to release it.
  • a valve repair procedure embodying this invention such as for reducing the valve orifice by using the apparatus described above, will be described next.
  • FIG. 1 shows the cannula schematically at 40 but the patient's body part are omitted from FIG. 1 .
  • the needle holder 30 is passed through the cannula 40 towards the leaflets, and the needle 25 held by the needle holder 30 is caused to penetrate and be completely pulled through one of the leaflets.
  • the knob 341 is pushed forward to release the needle 25 .
  • the knob 341 is pushed forward again to grab the same needle 25 from the other side of the leaflet to secure the needle 25 on the leaflet.
  • the needle 25 is released, the needle holder 30 is pulled out of the cannula 40 and the other of the needles 25 of the double-arm clip assembly 20 is similarly grabbed by its needle holder 30 .
  • the same procedure as described above is repeated to cause the second needle 25 of the clip assembly 20 to penetrate and be completely pulled through and be secured to the other of the leaflets.
  • the needles 25 are pulled, together with the flexible members 24 attached thereto, until the clip 22 comes to span the leaflets, as shown in FIG. 4A .
  • the release mechanisms 23 are squeezed by an instrument such as the needle holder 30 itself to release the clip 22 from the flexible members 24 .
  • the clip 22 now tends to return to its natural closed configuration, reducing the distance separating its two end points. This has the effect of tightly bringing the leaflets together, as shown in FIG. 4B , thereby reducing the valve orifice.
  • Such a single-arm clip assembly 20 ′ may be used similarly, as described above in connection with the double-arm clip assembly 20 shown in FIGS. 1 and 2 , except that the clip 22 ′ is provided with a stopper 26 at the other of its two end points not connected to the flexible member 24 for keeping the clip 22 ′ in its generally U-shaped open configuration.
  • the clip 22 ′ can be caused to pull the two leaflets together as the flexible member 24 is pulled, the stopper 26 serving to locate the clip 22 ′ across the leaflets.
  • FIG. 7 shows still another clip assembly 20 ′′ embodying this invention, indicating like components by the same numerals as used in FIGS. 2 and 5 .
  • This clip assembly 20 ′′ is characterized as having not only two tissue penetrating needles 25 each connected to a flexible member 24 but also two self-closing clips 22 ′ as shown in and explained with reference to FIG. 5 , each having a stopper 26 at one end point for keeping the clip 22 ′ in a generally U-shaped open configuration and the other end point being connected to a corresponding one of the flexible members 24 through a release mechanism 23 for separating the clip 22 ′ from the flexible member 24 and thereby releasing the clip 22 ′ from remaining in its open configuration.
  • These two clips 22 ′ are connected through their stoppers 26 by another flexible member 29 which may be a suture or a metal wire.
  • a clip assembly 22 ′ thus structured may be used in a valve repair procedure, for example, by penetrating a leaflet tissue with one of the needles 25 , causing it to come up and out at another position in a manner of ordinary stitching, pulling the associated flexible member 24 until the clip 22 ′ connected thereto penetrates the leaflet tissue partially such that the end point of this clip 22 ′ on the side of the release mechanism 23 penetrates the tissue and reappears on the surface while the other end point on the side of the stopped 26 does not penetrate the tissue, and doing the same with the other needle 25 on the leaflet on the opposite side of the valve opening.
  • each clip 22 ′ tends to coil up, getting firmly attached to the respective leaflet, the flexible member 29 therebetween holding the leaflets together, as shown in FIGS. 8A and 8B .
  • the needles 25 may be operated such that the connecting flexible member 29 makes a loop between the leaflets, as shown in FIG. 8C .
  • the clips 22 and 22 ′ when constrained to an open configuration before they are released from the flexible member 24 , are described as being generally U-shaped, this description is intended to be interpreted broadly. As should be clear from the intended function of the clips 22 and 22 ′, their open configuration may look more like a C or a J than a U.
  • the release mechanisms 23 described above as serving to release the connection between the clip 22 or 22 ′ and the flexible members 24 and to release the clip 22 or 22 ′ from its forced open configuration, may be structured as disclosed in aforementioned U.S. patent application Ser. No. 09/260,623 but their structure is not intended to limit the scope of the invention.

Abstract

An apparatus for minimally invasive valve repair includes first and second needles, first and second flexible members, a clip, and first and second release mechanisms. The needles are each releasably connected to one of the opposing end points of the clip through a corresponding one of the flexible members via a corresponding one of the release mechanisms.

Description

    CROSS-REFERENCE TO RELATED APPLICATIONS
  • This application is a divisional of co-pending U.S. patent application Ser. No. 11/007,825, filed Dec. 7, 2004, now U.S. Pat. No. 7,914,544, issued Mar. 29, 2011, which is a continuation of U.S. patent application Ser. No. 09/686,004, filed Oct. 10, 2000, now U.S. Pat. No. 6,926,730, issued Aug. 9, 2005, the entire contents of which are incorporated by reference herein.
  • BACKGROUND OF THE INVENTION
  • This invention relates to methods and apparatus for minimally invasive valve repair and more particularly to minimally invasive methods and apparatus for reducing the valve orifice.
  • Valve repair is currently done in open surgical procedures as described, for example, by F. Maisano, et al. in their article entitled “The double-orifice technique as a standardized approach to treat mitral regurgitation due to severe myxomatous disease” which appeared in European Journal of Cardio-thoracic Surgery, Vol. 17 (2000) 201-205. Cumbersome suture management, knot tying, pain and long recovery time are inherent to such open surgical procedures. It now goes without saying that minimally invasive surgery is the preferred procedure, having allowed surgeons to perform procedures with less pain and disability than open surgical procedures. Tissue-connector apparatus and methods usable in such minimally invasive surgery procedures have recently been disclosed in U.S. patent applications Ser. Nos. 09/089,884 and 09/090,305 both filed Jun. 3, 1998 and Ser. Nos. 09/259,705 and 09/260,623 both filed Mar. 1, 2000.
  • It is therefore a general object of this invention to provide improved minimally invasive methods and apparatus for coaptation of leaflets in the case of regurgitation to reduce the annular orifice.
  • It is a more specific object of this invention to provide such improved minimally invasive methods and apparatus using a tissue-connector apparatus disclosed in aforementioned U.S. patent applications.
  • SUMMARY OF THE INVENTION
  • Methods and apparatus embodying this invention with which the above and other objects can be accomplished are characterized as using a clip of a self-closing type as a tissue connector to capture leaflets and secure them together. Such a clip is typically U-shaped, having two end points, when it is constrained to be in an open configuration but is made of a wire of a shape memory material such that it tends to coil up to assume its natural closed configuration. Thus, if such a clip is placed between a pair of valve leaflets to be repaired, having each of its end points penetrating and completely passing through a different one of the leaflets while being constrained to be in its open configuration, and if the constraint which has been keeping the clip in its open configuration is then removed, it naturally tends to coil up, although it will not come to assume its natural closed configuration because it is hooked to the leaflets, tending nevertheless to reduce the distance of separation between its two end points. This has the effect of holding the leaflets together.
  • Such a clip may be deployed in the form of a clip assembly, having at least one of the end points of the clip connected to a tissue-piecing needle through a flexible member such as a suture and a release mechanism by which the clip can be easily released. The needle is attached to the front end of a needle-holder and passed through a cannula inserted through an incision towards the valve leaflets to be repaired. The needle-holder, according to a preferred embodiment of the invention, is formed with an outer tube and an inner member which is slidable inside the outer tube and is designed such that as the inner member is pushed forward against the biasing force of a spring contained in the outer tube, a slit which is provided at the front end becomes wider for accepting the needle therein but as the inner member is allowed to move to a backward position, the slit becomes narrower and grips the needle tightly.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • The accompanying drawings, which are incorporated in and form a part of this specification, illustrate embodiments of the invention and, together with the description, serve to explain the principles of the invention. In the drawings:
  • FIG. 1 is a schematic view of a tissue-connector apparatus embodying this invention when it is about to be used, its double-arm clip assembly being shown as a diagonal view and its needle holder being shown as a sectional side view;
  • FIG. 2 is an enlarged external view of the double-arm clip assembly of FIG. 1;
  • FIG. 3 is an enlarged sectional view of a portion of the needle holder near its front end;
  • FIG. 4A is a schematic diagonal view of the clip assembly of FIGS. 1 and 2 being used in a valve repair procedure embodying this invention, and FIG. 4B is another schematic diagonal view of the clip of FIG. 4A after it has been released;
  • FIG. 5 is an external view of a single-arm clip assembly which may be used in a method of minimally invasive valve repair embodying this invention;
  • FIG. 6 is a schematic sectional view for showing a method of valve repair embodying this invention by using the single-arm clip assembly of FIG. 5;
  • FIG. 7 is another clip assembly embodying this invention; and
  • FIG. 8A is a schematic sectional view of leaflets repaired by a clip assembly of FIG. 7, FIG. 8B is a top view of the leaflets of FIG. 8A, and FIG. 8C is a top view of leaflets repaired in an alternative manner.
  • Throughout herein like components are indicated by the same numerals even where they are components of different assemblies and may not necessarily described repetitiously.
  • The schematic drawings are intended to be indeed schematic and only to show the basic concepts of the invention, not necessarily representing realistic views, for example, with realistic relative sizes of body components and apparatus components.
  • DETAILED DESCRIPTION OF THE INVENTION
  • The invention is described next by way of examples. FIG. 1 shows schematically a tissue-connector apparatus 10 embodying this invention for a minimally invasive procedure. Described briefly, the apparatus 10 consists of a clip assembly 20 and a needle holder 30, which will be described next sequentially in detail.
  • The clip assembly 20 according to this embodiment may be referred to as the double-arm clip assembly, characterized as having a clip 22 of a self-closing type with two end points each connected through a flexible member 24 such as a suture to a tissue penetrating needle 25 (as disclosed, for example, in aforementioned U.S. patent applications Ser. Nos. 09/259,705 and 09/260,623 both filed Mar. 1, 2000, both of which are herein incorporated by reference). Each of the needles 25 has a tissue-piercing sharp point and is connected to a corresponding one of the flexible members 24. As shown more clearly in FIG. 2, the two end points of the clip 22 are each provided with and directly connected to a release mechanism 23 such that it can be released easily from the flexible members 24 and from being constrained to remain in its generally U-shaped open configuration.
  • The clip 22, or a surgical fastener, of the so-called self-closing type may be one disclosed in aforementioned U.S. patent applications Ser. Nos. 09/089,884 and 09/090,305 both filed Jun. 3, 1998 (herein also incorporated by reference), as well as in aforementioned U.S. patent applications Ser. Nos. 09/259,705 and 09/260,623, characterized as having two end points, being generally U-shaped when in an open configuration (as shown in FIGS. 1 and 2), being naturally in a closed configuration (state or condition) and being elastic (or pseudoelastic, but herein broadly characterized as being “elastic”) so as to tend to return to the closed configuration by reducing the separation distance between its end points when forced into an open configuration. As disclosed in aforementioned U.S. patent applications Ser. Nos. 09/089,884 and 09/090,305, such a clip 22 may comprise a deformable wire made of a shape memory alloy such as a nickel titanium based alloy (nitinol). It is also known that the alloy may include additional elements, depending on the desired yield strength of the material or the temperature at which particular pseudoelastic or shape transformation characteristics occur. When the clip 22 is in its closed configuration (not shown) with no external restraining force thereupon, it may be in a completely closed loop with its end points in a side-by-side or overlapping orientation, the wire being looped by more than 360°. The diameter of the wire for the clip 22 and the diameter of the loop when it is in the closed configuration may be selected, depending on the application, and do not limit the scope of the invention.
  • The needle holder 30 consists essentially of a hollow outer tube 32, an inner member 34 and a spring 38, as shown in FIG. 1. The outer tube 32 is elongated, defining a longitudinal direction. The inner member 34 is also longitudinally elongated and is adapted to slide longitudinally inside the outer tube 32 and to releasably grab the needles 25, one at a time. According to the embodiment shown in FIG. 1, the inner member 34 is comprised of a knob 341 at its proximal end, a conjunction tube 342 in the middle and a needle-holding tube 343 in front. The conjunction tube 342 and the needle holding tube 343 are laser-welded together. A threaded adapter is laser-welded to the proximal end of the conjunction tube 342 for allowing the knob 341 to be screwed thereonto after the spring 38 is inserted inside the outer tube 32 such that, once the needle holder 30 is thus assembled, the knob 341, the conjunction tube 342 and the needle-holding tube 343 will move together as a single unit. The front end of the needle-holding tube 343 is provided with a longitudinally elongated slit 35 for holding the needle 25, and the outer tube 32 has a front opening 33, as shown more clearly in FIG. 3. The needle-holding tube 343 with the slit 35 and the front opening 33 of the outer tube 32 are so designed that the slit 35 will open and become sufficiently wide in front as the inner member 34 is pushed forward through the outer tube 32 for accepting a needle 25 (shown by broken lines in FIG. 3) therein and that the opening of the slit 35 tends to become smaller as the inner member 34 is moved backwards through the outer tube 32 so as to retract the needle-holding tube 343 through the front opening 33 of the outer tube 32, causing the needle-holding tube 343 to securely grab the needle 25 once accepted. The spring 38 is disposed inside the outer tube 32 so as to provide a backward biasing force on the inner member 34. In other words, the inner member 34 is normally in a backward position inside the outer tube 32 under the influence of the backward biasing force of the spring 38 thereon. As the user pushes the inner member 34 forward by operating the knob 341 against aforementioned backward biasing force of the spring, the front part of the needle-holding tube 343 protrudes farther outward from the front opening 33 of the outer tube 32 and the slit 35 opens wider, its front opening becoming wide enough to accept the back part of a needle (away from its tissue-piercing sharp point). If the user then releases the force being applied to the knob 341 after the back part of the needle 25 has been accepted inside the slit 35, the backward biasing force by the spring pushes the inner member 34 backward, reducing the length of the needle-holding tube 343 outside the front opening 33 of the outer tube 32. This has the effect of reducing the opening of the slit 35 and hence of having the needle 25 firmly gripped by the needle holder 30. In summary, the user pushes the knob 341 forward to accept the needle 25 and releases the force on the knob 341 to firmly grab it. When a needle is already being held by the needle holder 30, the user has only to push the knob 341 to release it.
  • A valve repair procedure embodying this invention, such as for reducing the valve orifice by using the apparatus described above, will be described next.
  • To access a mitral valve, a small incision is made on the appendage of the left atrium. One of the needles 25 of the clip assembly 20 is grabbed by the needle holder 30, as shown in FIG. 1, by pushing the knob 341 forward to accept the needle 25 and then releasing it to firmly attach the needle 25 to the needle holder 30, as described above. A cannula is inserted into the incision. FIG. 1 shows the cannula schematically at 40 but the patient's body part are omitted from FIG. 1. With an aid of an ultrasound machine (not shown), the needle holder 30 is passed through the cannula 40 towards the leaflets, and the needle 25 held by the needle holder 30 is caused to penetrate and be completely pulled through one of the leaflets. Thereafter, the knob 341 is pushed forward to release the needle 25. The knob 341 is pushed forward again to grab the same needle 25 from the other side of the leaflet to secure the needle 25 on the leaflet. Thereafter, the needle 25 is released, the needle holder 30 is pulled out of the cannula 40 and the other of the needles 25 of the double-arm clip assembly 20 is similarly grabbed by its needle holder 30. The same procedure as described above is repeated to cause the second needle 25 of the clip assembly 20 to penetrate and be completely pulled through and be secured to the other of the leaflets. The needles 25 are pulled, together with the flexible members 24 attached thereto, until the clip 22 comes to span the leaflets, as shown in FIG. 4A. Thereafter, the release mechanisms 23 are squeezed by an instrument such as the needle holder 30 itself to release the clip 22 from the flexible members 24. Free of constraints, the clip 22 now tends to return to its natural closed configuration, reducing the distance separating its two end points. This has the effect of tightly bringing the leaflets together, as shown in FIG. 4B, thereby reducing the valve orifice.
  • The invention was described above by way of only one example but this example is not intended to limit the scope of the invention. Many modifications and variations are possible within the scope of the invention. For example, although the use of a clip assembly having two needles each connected to a corresponding one of the two end points of a generally U-shaped clip was disclosed, use may be made under certain circumstances of a simpler single-arm clip assembly 20′ shown in FIG. 5 and described, for example, in aforementioned U.S. patent applications Ser. Nos. 09/089,884 and 09/090,305, having only one needle 25 attached through a flexible member 24 and a release mechanism 23 to one of the two end points of a clip 22′. Such a single-arm clip assembly 20′ may be used similarly, as described above in connection with the double-arm clip assembly 20 shown in FIGS. 1 and 2, except that the clip 22′ is provided with a stopper 26 at the other of its two end points not connected to the flexible member 24 for keeping the clip 22′ in its generally U-shaped open configuration. After the needle 25 is caused to penetrate both leaflets, as shown in FIG. 6, the clip 22′ can be caused to pull the two leaflets together as the flexible member 24 is pulled, the stopper 26 serving to locate the clip 22′ across the leaflets.
  • FIG. 7 shows still another clip assembly 20″ embodying this invention, indicating like components by the same numerals as used in FIGS. 2 and 5. This clip assembly 20″ is characterized as having not only two tissue penetrating needles 25 each connected to a flexible member 24 but also two self-closing clips 22′ as shown in and explained with reference to FIG. 5, each having a stopper 26 at one end point for keeping the clip 22′ in a generally U-shaped open configuration and the other end point being connected to a corresponding one of the flexible members 24 through a release mechanism 23 for separating the clip 22′ from the flexible member 24 and thereby releasing the clip 22′ from remaining in its open configuration. These two clips 22′ are connected through their stoppers 26 by another flexible member 29 which may be a suture or a metal wire.
  • A clip assembly 22′ thus structured may be used in a valve repair procedure, for example, by penetrating a leaflet tissue with one of the needles 25, causing it to come up and out at another position in a manner of ordinary stitching, pulling the associated flexible member 24 until the clip 22′ connected thereto penetrates the leaflet tissue partially such that the end point of this clip 22′ on the side of the release mechanism 23 penetrates the tissue and reappears on the surface while the other end point on the side of the stopped 26 does not penetrate the tissue, and doing the same with the other needle 25 on the leaflet on the opposite side of the valve opening. After the release mechanisms 23 on both clips 22′ are pressed, as described above, to release the clips 22′ from the needles 25, each clip 22′ tends to coil up, getting firmly attached to the respective leaflet, the flexible member 29 therebetween holding the leaflets together, as shown in FIGS. 8A and 8B. In other words, it is the flexible member 29 between the two clips 22′ that holds the leaflets together. As an alternative procedure, the needles 25 may be operated such that the connecting flexible member 29 makes a loop between the leaflets, as shown in FIG. 8C.
  • Although the clips 22 and 22′, when constrained to an open configuration before they are released from the flexible member 24, are described as being generally U-shaped, this description is intended to be interpreted broadly. As should be clear from the intended function of the clips 22 and 22′, their open configuration may look more like a C or a J than a U. The release mechanisms 23, described above as serving to release the connection between the clip 22 or 22′ and the flexible members 24 and to release the clip 22 or 22′ from its forced open configuration, may be structured as disclosed in aforementioned U.S. patent application Ser. No. 09/260,623 but their structure is not intended to limit the scope of the invention.
  • In summary, the disclosure is intended to be interpreted broadly. Although the invention has been described as being addressed to a method and an apparatus for valve repair, a person skilled in the art will immediately realize that the method and apparatus of this invention as described above can be used for holding two tissue parts close together, not being limited to valve leaflets. The scope of this invention, therefore, is to be understood as including methods of and apparatus for holding two tissue parts close together.

Claims (6)

1-23. (canceled)
24. Apparatus for minimally invasive valve repair, the apparatus comprising: a first and second needle; a first and second flexible member; a clip having an open configuration and a closed configuration, the clip having a first and second end point, the first needle being connected through the first flexible member to the first end point and the second needle being connected through the second flexible member to the second end point; and a first and second release mechanism, wherein the first release mechanism releasably connects the first flexible member to the first end point and the second release mechanism releasably connects the second flexible member to the second end point.
25. The apparatus of claim 24 wherein the clip is generally U-shaped when in the open configuration.
26. The apparatus of claim 24 wherein the clip comprises a wire made of shape memory material.
27. The apparatus of claim 24 wherein the clip in the closed configuration is looped by more than 360 degrees.
28-42. (canceled)
US13/038,676 2000-10-10 2011-03-02 Minimally Invasive Valve Repair Procedure and Apparatus Abandoned US20110213387A1 (en)

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US09/686,004 US6926730B1 (en) 2000-10-10 2000-10-10 Minimally invasive valve repair procedure and apparatus
US11/007,825 US7914544B2 (en) 2000-10-10 2004-12-07 Minimally invasive valve repair procedure and apparatus
US13/038,676 US20110213387A1 (en) 2000-10-10 2011-03-02 Minimally Invasive Valve Repair Procedure and Apparatus

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US10/718,236 Expired - Fee Related US7744611B2 (en) 2000-10-10 2003-11-19 Minimally invasive valve repair procedure and apparatus
US11/007,825 Expired - Fee Related US7914544B2 (en) 2000-10-10 2004-12-07 Minimally invasive valve repair procedure and apparatus
US13/038,676 Abandoned US20110213387A1 (en) 2000-10-10 2011-03-02 Minimally Invasive Valve Repair Procedure and Apparatus

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US11/007,825 Expired - Fee Related US7914544B2 (en) 2000-10-10 2004-12-07 Minimally invasive valve repair procedure and apparatus

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10792036B2 (en) 2017-11-15 2020-10-06 Winter Innovations, Llc Method and apparatus for double loop stitching
US11026791B2 (en) 2018-03-20 2021-06-08 Medtronic Vascular, Inc. Flexible canopy valve repair systems and methods of use
US11213290B2 (en) 2017-11-15 2022-01-04 Winter Innovations, Inc. Methods and systems for double loop stitching
US11285003B2 (en) 2018-03-20 2022-03-29 Medtronic Vascular, Inc. Prolapse prevention device and methods of use thereof
US11931261B2 (en) 2022-02-17 2024-03-19 Medtronic Vascular, Inc. Prolapse prevention device and methods of use thereof

Families Citing this family (342)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2768324B1 (en) * 1997-09-12 1999-12-10 Jacques Seguin SURGICAL INSTRUMENT FOR PERCUTANEOUSLY FIXING TWO AREAS OF SOFT TISSUE, NORMALLY MUTUALLY REMOTE, TO ONE ANOTHER
US6641593B1 (en) * 1998-06-03 2003-11-04 Coalescent Surgical, Inc. Tissue connector apparatus and methods
US6945980B2 (en) * 1998-06-03 2005-09-20 Medtronic, Inc. Multiple loop tissue connector apparatus and methods
US6613059B2 (en) * 1999-03-01 2003-09-02 Coalescent Surgical, Inc. Tissue connector apparatus and methods
US8118822B2 (en) 1999-03-01 2012-02-21 Medtronic, Inc. Bridge clip tissue connector apparatus and methods
US6695859B1 (en) 1999-04-05 2004-02-24 Coalescent Surgical, Inc. Apparatus and methods for anastomosis
AU770243B2 (en) 1999-04-09 2004-02-19 Evalve, Inc. Methods and apparatus for cardiac valve repair
US7563267B2 (en) 1999-04-09 2009-07-21 Evalve, Inc. Fixation device and methods for engaging tissue
US7811296B2 (en) * 1999-04-09 2010-10-12 Evalve, Inc. Fixation devices for variation in engagement of tissue
US20040044350A1 (en) 1999-04-09 2004-03-04 Evalve, Inc. Steerable access sheath and methods of use
US8216256B2 (en) 1999-04-09 2012-07-10 Evalve, Inc. Detachment mechanism for implantable fixation devices
US6752813B2 (en) 1999-04-09 2004-06-22 Evalve, Inc. Methods and devices for capturing and fixing leaflets in valve repair
US10327743B2 (en) * 1999-04-09 2019-06-25 Evalve, Inc. Device and methods for endoscopic annuloplasty
US8529583B1 (en) 1999-09-03 2013-09-10 Medtronic, Inc. Surgical clip removal apparatus
US6926730B1 (en) 2000-10-10 2005-08-09 Medtronic, Inc. Minimally invasive valve repair procedure and apparatus
US6551332B1 (en) 2000-03-31 2003-04-22 Coalescent Surgical, Inc. Multiple bias surgical fastener
US6602286B1 (en) 2000-10-26 2003-08-05 Ernst Peter Strecker Implantable valve system
US20020173803A1 (en) * 2001-05-01 2002-11-21 Stephen Ainsworth Self-closing surgical clip for tissue
US6575971B2 (en) * 2001-11-15 2003-06-10 Quantum Cor, Inc. Cardiac valve leaflet stapler device and methods thereof
US7201771B2 (en) 2001-12-27 2007-04-10 Arbor Surgical Technologies, Inc. Bioprosthetic heart valve
US7048754B2 (en) * 2002-03-01 2006-05-23 Evalve, Inc. Suture fasteners and methods of use
US6752828B2 (en) 2002-04-03 2004-06-22 Scimed Life Systems, Inc. Artificial valve
GB2390544B (en) * 2002-06-25 2005-07-13 Michael Harold Jones Surgical needle holder
US7959674B2 (en) 2002-07-16 2011-06-14 Medtronic, Inc. Suture locking assembly and method of use
US8758372B2 (en) 2002-08-29 2014-06-24 St. Jude Medical, Cardiology Division, Inc. Implantable devices for controlling the size and shape of an anatomical structure or lumen
KR101050626B1 (en) * 2002-08-29 2011-07-19 미트랄 솔루션스, 인크. Implantation device for controlling the inner circumference of the anatomical orifice or lumen
US8066724B2 (en) 2002-09-12 2011-11-29 Medtronic, Inc. Anastomosis apparatus and methods
US8105345B2 (en) 2002-10-04 2012-01-31 Medtronic, Inc. Anastomosis apparatus and methods
WO2004037128A1 (en) 2002-10-24 2004-05-06 Boston Scientific Limited Venous valve apparatus and method
US8551162B2 (en) 2002-12-20 2013-10-08 Medtronic, Inc. Biologically implantable prosthesis
US6945957B2 (en) 2002-12-30 2005-09-20 Scimed Life Systems, Inc. Valve treatment catheter and methods
ES2616695T3 (en) 2003-03-11 2017-06-14 Covidien Lp Staple application device with inclined jaw
US10667823B2 (en) 2003-05-19 2020-06-02 Evalve, Inc. Fixation devices, systems and methods for engaging tissue
US7182769B2 (en) 2003-07-25 2007-02-27 Medtronic, Inc. Sealing clip, delivery systems, and methods
ATE328686T1 (en) * 2003-08-05 2006-06-15 Lasag Ag METHOD FOR PRODUCING A MEDICAL NEEDLE
US20050043749A1 (en) 2003-08-22 2005-02-24 Coalescent Surgical, Inc. Eversion apparatus and methods
US8021421B2 (en) 2003-08-22 2011-09-20 Medtronic, Inc. Prosthesis heart valve fixturing device
US8394114B2 (en) 2003-09-26 2013-03-12 Medtronic, Inc. Surgical connection apparatus and methods
US7556647B2 (en) 2003-10-08 2009-07-07 Arbor Surgical Technologies, Inc. Attachment device and methods of using the same
US7879047B2 (en) 2003-12-10 2011-02-01 Medtronic, Inc. Surgical connection apparatus and methods
US7854761B2 (en) 2003-12-19 2010-12-21 Boston Scientific Scimed, Inc. Methods for venous valve replacement with a catheter
US8128681B2 (en) 2003-12-19 2012-03-06 Boston Scientific Scimed, Inc. Venous valve apparatus, system, and method
EP1750592B1 (en) 2004-05-14 2016-12-28 Evalve, Inc. Locking mechanisms for fixation devices
US7566343B2 (en) 2004-09-02 2009-07-28 Boston Scientific Scimed, Inc. Cardiac valve, system, and method
US7635329B2 (en) 2004-09-27 2009-12-22 Evalve, Inc. Methods and devices for tissue grasping and assessment
US8052592B2 (en) 2005-09-27 2011-11-08 Evalve, Inc. Methods and devices for tissue grasping and assessment
US9763668B2 (en) 2004-10-08 2017-09-19 Covidien Lp Endoscopic surgical clip applier
US7819886B2 (en) 2004-10-08 2010-10-26 Tyco Healthcare Group Lp Endoscopic surgical clip applier
ES2388673T3 (en) 2004-10-08 2012-10-17 Tyco Healthcare Group Lp An endoscopic clip or surgical clip applier
WO2006042110A2 (en) 2004-10-08 2006-04-20 Tyco Healthcare Group, Lp Apparatus for applying surgical clips
US8409222B2 (en) 2004-10-08 2013-04-02 Covidien Lp Endoscopic surgical clip applier
EP1845861B1 (en) 2005-01-21 2011-06-22 Mayo Foundation for Medical Education and Research Thorascopic heart valve repair apparatus
US7854755B2 (en) 2005-02-01 2010-12-21 Boston Scientific Scimed, Inc. Vascular catheter, system, and method
US20060173490A1 (en) 2005-02-01 2006-08-03 Boston Scientific Scimed, Inc. Filter system and method
US7878966B2 (en) 2005-02-04 2011-02-01 Boston Scientific Scimed, Inc. Ventricular assist and support device
EP3967269A3 (en) 2005-02-07 2022-07-13 Evalve, Inc. Systems and devices for cardiac valve repair
US8470028B2 (en) 2005-02-07 2013-06-25 Evalve, Inc. Methods, systems and devices for cardiac valve repair
US7670368B2 (en) 2005-02-07 2010-03-02 Boston Scientific Scimed, Inc. Venous valve apparatus, system, and method
US7780722B2 (en) 2005-02-07 2010-08-24 Boston Scientific Scimed, Inc. Venous valve apparatus, system, and method
US7867274B2 (en) 2005-02-23 2011-01-11 Boston Scientific Scimed, Inc. Valve apparatus, system and method
US8608797B2 (en) 2005-03-17 2013-12-17 Valtech Cardio Ltd. Mitral valve treatment techniques
EP2626039B1 (en) * 2005-03-25 2015-10-14 St. Jude Medical, Cardiology Division, Inc. Apparatus for controlling the internal circumference of an anatomic orifice or lumen
US8864823B2 (en) 2005-03-25 2014-10-21 StJude Medical, Cardiology Division, Inc. Methods and apparatus for controlling the internal circumference of an anatomic orifice or lumen
US7513909B2 (en) 2005-04-08 2009-04-07 Arbor Surgical Technologies, Inc. Two-piece prosthetic valves with snap-in connection and methods for use
US7722666B2 (en) 2005-04-15 2010-05-25 Boston Scientific Scimed, Inc. Valve apparatus, system and method
US8211169B2 (en) 2005-05-27 2012-07-03 Medtronic, Inc. Gasket with collar for prosthetic heart valves and methods for using them
US8012198B2 (en) 2005-06-10 2011-09-06 Boston Scientific Scimed, Inc. Venous valve, system, and method
US8951285B2 (en) 2005-07-05 2015-02-10 Mitralign, Inc. Tissue anchor, anchoring system and methods of using the same
US7569071B2 (en) 2005-09-21 2009-08-04 Boston Scientific Scimed, Inc. Venous valve, system, and method with sinus pocket
US8043368B2 (en) 2005-11-23 2011-10-25 Traves Dean Crabtree Methods and apparatus for atrioventricular valve repair
US7799038B2 (en) 2006-01-20 2010-09-21 Boston Scientific Scimed, Inc. Translumenal apparatus, system, and method
US7967857B2 (en) 2006-01-27 2011-06-28 Medtronic, Inc. Gasket with spring collar for prosthetic heart valves and methods for making and using them
US8406901B2 (en) 2006-04-27 2013-03-26 Medtronic, Inc. Sutureless implantable medical device fixation
WO2007130881A2 (en) 2006-04-29 2007-11-15 Arbor Surgical Technologies, Inc. Multiple component prosthetic heart valve assemblies and apparatus and methods for delivering them
EP2314232B1 (en) 2006-10-17 2015-03-25 Covidien LP Apparatus for applying surgical clips
US7765012B2 (en) * 2006-11-30 2010-07-27 Medtronic, Inc. Implantable medical device including a conductive fixation element
US9492657B2 (en) 2006-11-30 2016-11-15 Medtronic, Inc. Method of implanting a medical device including a fixation element
WO2010004546A1 (en) 2008-06-16 2010-01-14 Valtech Cardio, Ltd. Annuloplasty devices and methods of delivery therefor
JP2010511469A (en) * 2006-12-05 2010-04-15 バルテック カーディオ,リミティド Segmented ring placement
US9883943B2 (en) 2006-12-05 2018-02-06 Valtech Cardio, Ltd. Implantation of repair devices in the heart
US11259924B2 (en) 2006-12-05 2022-03-01 Valtech Cardio Ltd. Implantation of repair devices in the heart
EP2111189B1 (en) 2007-01-03 2017-04-05 St. Jude Medical, Cardiology Division, Inc. Implantable devices for controlling the size and shape of an anatomical structure or lumen
US8133270B2 (en) 2007-01-08 2012-03-13 California Institute Of Technology In-situ formation of a valve
JP5313928B2 (en) 2007-02-05 2013-10-09 ボストン サイエンティフィック リミテッド Percutaneous valves and systems
US9427215B2 (en) 2007-02-05 2016-08-30 St. Jude Medical, Cardiology Division, Inc. Minimally invasive system for delivering and securing an annular implant
US11660190B2 (en) 2007-03-13 2023-05-30 Edwards Lifesciences Corporation Tissue anchors, systems and methods, and devices
CN101641051B (en) 2007-03-26 2011-11-23 Tyco医疗健康集团 Endoscopic surgical clip applier
EP2671519B1 (en) 2007-04-11 2014-12-17 Covidien LP Surgical clip applier
US8828079B2 (en) 2007-07-26 2014-09-09 Boston Scientific Scimed, Inc. Circulatory valve, system and method
CA2703129C (en) 2007-10-18 2016-02-16 Neochord Inc. Minimially invasive repair of a valve leaflet in a beating heart
US7892276B2 (en) 2007-12-21 2011-02-22 Boston Scientific Scimed, Inc. Valve with delayed leaflet deployment
US8439936B2 (en) 2008-03-06 2013-05-14 Zone 2 Surgical, Inc. Device and method for tendon, ligament or soft tissue repair
US8177836B2 (en) 2008-03-10 2012-05-15 Medtronic, Inc. Apparatus and methods for minimally invasive valve repair
US8382829B1 (en) 2008-03-10 2013-02-26 Mitralign, Inc. Method to reduce mitral regurgitation by cinching the commissure of the mitral valve
US10376261B2 (en) * 2008-04-01 2019-08-13 Covidien Lp Anchoring suture
US7954688B2 (en) * 2008-08-22 2011-06-07 Medtronic, Inc. Endovascular stapling apparatus and methods of use
US20110208212A1 (en) 2010-02-19 2011-08-25 Zergiebel Earl M Surgical clip applier
US8056565B2 (en) 2008-08-25 2011-11-15 Tyco Healthcare Group Lp Surgical clip applier and method of assembly
US8465502B2 (en) 2008-08-25 2013-06-18 Covidien Lp Surgical clip applier and method of assembly
US8409223B2 (en) 2008-08-29 2013-04-02 Covidien Lp Endoscopic surgical clip applier with clip retention
US8585717B2 (en) 2008-08-29 2013-11-19 Covidien Lp Single stroke endoscopic surgical clip applier
US9358015B2 (en) 2008-08-29 2016-06-07 Covidien Lp Endoscopic surgical clip applier with wedge plate
US8267944B2 (en) 2008-08-29 2012-09-18 Tyco Healthcare Group Lp Endoscopic surgical clip applier with lock out
US10517719B2 (en) 2008-12-22 2019-12-31 Valtech Cardio, Ltd. Implantation of repair devices in the heart
US8715342B2 (en) 2009-05-07 2014-05-06 Valtech Cardio, Ltd. Annuloplasty ring with intra-ring anchoring
US9011530B2 (en) 2008-12-22 2015-04-21 Valtech Cardio, Ltd. Partially-adjustable annuloplasty structure
WO2010073246A2 (en) 2008-12-22 2010-07-01 Valtech Cardio, Ltd. Adjustable annuloplasty devices and adjustment mechanisms therefor
US8940044B2 (en) 2011-06-23 2015-01-27 Valtech Cardio, Ltd. Closure element for use with an annuloplasty structure
US8241351B2 (en) 2008-12-22 2012-08-14 Valtech Cardio, Ltd. Adjustable partial annuloplasty ring and mechanism therefor
US8545553B2 (en) 2009-05-04 2013-10-01 Valtech Cardio, Ltd. Over-wire rotation tool
US9204965B2 (en) * 2009-01-14 2015-12-08 Lc Therapeutics, Inc. Synthetic chord
AU2010206732A1 (en) 2009-01-22 2011-08-25 St. Jude Medical, Cardiology Division, Inc. Post-operative adjustment tool, minimally invasive attachment apparatus, and adjustable tricuspid ring
BRPI1007540A2 (en) * 2009-01-22 2016-02-16 St Jude Medical Cardiology Div device and method for adjusting at least one of the shape and size of an anatomical or lumen orifice
US8353956B2 (en) 2009-02-17 2013-01-15 Valtech Cardio, Ltd. Actively-engageable movement-restriction mechanism for use with an annuloplasty structure
US8518060B2 (en) 2009-04-09 2013-08-27 Medtronic, Inc. Medical clip with radial tines, system and method of using same
US8734484B2 (en) 2009-04-21 2014-05-27 Medtronic, Inc. System and method for closure of an internal opening in tissue, such as a trans-apical access opening
US8668704B2 (en) 2009-04-24 2014-03-11 Medtronic, Inc. Medical clip with tines, system and method of using same
WO2013069019A2 (en) 2011-11-08 2013-05-16 Valtech Cardio, Ltd. Controlled steering functionality for implant-delivery tool
US9968452B2 (en) 2009-05-04 2018-05-15 Valtech Cardio, Ltd. Annuloplasty ring delivery cathethers
EP2263608B1 (en) * 2009-06-19 2016-09-07 Arthrex, Inc. Bone-tendon-bone suture button construct
US9011487B2 (en) * 2009-08-27 2015-04-21 Ethicon, Inc. Barbed sutures having pledget stoppers and methods therefor
US8210085B2 (en) * 2009-08-27 2012-07-03 Ethicon, Inc. Automated systems and methods for making braided barbed sutures
EP2633821B1 (en) 2009-09-15 2016-04-06 Evalve, Inc. Device for cardiac valve repair
US8734469B2 (en) 2009-10-13 2014-05-27 Covidien Lp Suture clip applier
US9011520B2 (en) 2009-10-29 2015-04-21 Valtech Cardio, Ltd. Tissue anchor for annuloplasty device
US10098737B2 (en) 2009-10-29 2018-10-16 Valtech Cardio, Ltd. Tissue anchor for annuloplasty device
US9180007B2 (en) 2009-10-29 2015-11-10 Valtech Cardio, Ltd. Apparatus and method for guide-wire based advancement of an adjustable implant
EP2506777B1 (en) 2009-12-02 2020-11-25 Valtech Cardio, Ltd. Combination of spool assembly coupled to a helical anchor and delivery tool for implantation thereof
US8870950B2 (en) 2009-12-08 2014-10-28 Mitral Tech Ltd. Rotation-based anchoring of an implant
US9186136B2 (en) 2009-12-09 2015-11-17 Covidien Lp Surgical clip applier
US8545486B2 (en) 2009-12-15 2013-10-01 Covidien Lp Surgical clip applier
US9072603B2 (en) * 2010-02-24 2015-07-07 Medtronic Ventor Technologies, Ltd. Mitral prosthesis and methods for implantation
US8403945B2 (en) 2010-02-25 2013-03-26 Covidien Lp Articulating endoscopic surgical clip applier
US20110224785A1 (en) * 2010-03-10 2011-09-15 Hacohen Gil Prosthetic mitral valve with tissue anchors
US8992604B2 (en) 2010-07-21 2015-03-31 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
US9132009B2 (en) 2010-07-21 2015-09-15 Mitraltech Ltd. Guide wires with commissural anchors to advance a prosthetic valve
US11653910B2 (en) 2010-07-21 2023-05-23 Cardiovalve Ltd. Helical anchor implantation
US9763657B2 (en) 2010-07-21 2017-09-19 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
US8403946B2 (en) 2010-07-28 2013-03-26 Covidien Lp Articulating clip applier cartridge
US8968337B2 (en) 2010-07-28 2015-03-03 Covidien Lp Articulating clip applier
WO2012048348A1 (en) * 2010-10-08 2012-04-12 Prywes Arnold S Apparatus and method for performing ocular surgery
US9011464B2 (en) 2010-11-02 2015-04-21 Covidien Lp Self-centering clip and jaw
US9775982B2 (en) 2010-12-29 2017-10-03 Medtronic, Inc. Implantable medical device fixation
US10112045B2 (en) 2010-12-29 2018-10-30 Medtronic, Inc. Implantable medical device fixation
EP2658480B1 (en) 2010-12-29 2017-11-01 Neochord Inc. Exchangeable system for minimally invasive beating heart repair of heart valve leaflets
US8888843B2 (en) 2011-01-28 2014-11-18 Middle Peak Medical, Inc. Device, system, and method for transcatheter treatment of valve regurgitation
US8845717B2 (en) 2011-01-28 2014-09-30 Middle Park Medical, Inc. Coaptation enhancement implant, system, and method
US9186153B2 (en) 2011-01-31 2015-11-17 Covidien Lp Locking cam driver and jaw assembly for clip applier
US9775623B2 (en) 2011-04-29 2017-10-03 Covidien Lp Surgical clip applier including clip relief feature
WO2012167120A2 (en) 2011-06-01 2012-12-06 Neochord, Inc. Minimally invasive repair of heart valve leaflets
US10792152B2 (en) 2011-06-23 2020-10-06 Valtech Cardio, Ltd. Closed band for percutaneous annuloplasty
US9668859B2 (en) 2011-08-05 2017-06-06 California Institute Of Technology Percutaneous heart valve delivery systems
US20140324164A1 (en) 2011-08-05 2014-10-30 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
EP2739214B1 (en) 2011-08-05 2018-10-10 Cardiovalve Ltd Percutaneous mitral valve replacement and sealing
WO2013021374A2 (en) 2011-08-05 2013-02-14 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
US8852272B2 (en) 2011-08-05 2014-10-07 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
US9011468B2 (en) 2011-09-13 2015-04-21 Abbott Cardiovascular Systems Inc. Independent gripper
US8945177B2 (en) 2011-09-13 2015-02-03 Abbott Cardiovascular Systems Inc. Gripper pusher mechanism for tissue apposition systems
US9788838B2 (en) 2011-10-11 2017-10-17 Zone 2 Surgical, Inc. Tissue device
US8858623B2 (en) 2011-11-04 2014-10-14 Valtech Cardio, Ltd. Implant having multiple rotational assemblies
US20130131697A1 (en) 2011-11-21 2013-05-23 Covidien Lp Surgical clip applier
US8968336B2 (en) 2011-12-07 2015-03-03 Edwards Lifesciences Corporation Self-cinching surgical clips and delivery system
US9364239B2 (en) 2011-12-19 2016-06-14 Covidien Lp Jaw closure mechanism for a surgical clip applier
US9017347B2 (en) 2011-12-22 2015-04-28 Edwards Lifesciences Corporation Suture clip deployment devices
US9364216B2 (en) 2011-12-29 2016-06-14 Covidien Lp Surgical clip applier with integrated clip counter
US9339197B2 (en) 2012-03-26 2016-05-17 Medtronic, Inc. Intravascular implantable medical device introduction
US9220906B2 (en) 2012-03-26 2015-12-29 Medtronic, Inc. Tethered implantable medical device deployment
US10485435B2 (en) 2012-03-26 2019-11-26 Medtronic, Inc. Pass-through implantable medical device delivery catheter with removeable distal tip
US9854982B2 (en) 2012-03-26 2018-01-02 Medtronic, Inc. Implantable medical device deployment within a vessel
US9717421B2 (en) 2012-03-26 2017-08-01 Medtronic, Inc. Implantable medical device delivery catheter with tether
US9833625B2 (en) 2012-03-26 2017-12-05 Medtronic, Inc. Implantable medical device delivery with inner and outer sheaths
US9585654B2 (en) * 2012-05-01 2017-03-07 Dean & Webb, LLC Segmentally rigid suture and suturing technique
US9408610B2 (en) 2012-05-04 2016-08-09 Covidien Lp Surgical clip applier with dissector
US9532787B2 (en) 2012-05-31 2017-01-03 Covidien Lp Endoscopic clip applier
US9498202B2 (en) 2012-07-10 2016-11-22 Edwards Lifesciences Corporation Suture securement devices
US9592048B2 (en) 2013-07-11 2017-03-14 Edwards Lifesciences Corporation Knotless suture fastener installation system
US10016193B2 (en) 2013-11-18 2018-07-10 Edwards Lifesciences Ag Multiple-firing crimp device and methods for using and manufacturing same
US9351648B2 (en) 2012-08-24 2016-05-31 Medtronic, Inc. Implantable medical device electrode assembly
CA2885354A1 (en) 2012-09-29 2014-04-03 Mitralign, Inc. Plication lock delivery system and method of use thereof
US10376266B2 (en) 2012-10-23 2019-08-13 Valtech Cardio, Ltd. Percutaneous tissue anchor techniques
EP3517052A1 (en) 2012-10-23 2019-07-31 Valtech Cardio, Ltd. Controlled steering functionality for implant-delivery tool
US9351719B2 (en) 2012-11-01 2016-05-31 Zone 2 Surgical, Inc. Self locking knotless suture
US9427228B2 (en) * 2012-11-09 2016-08-30 Karl Storz Gmbh & Co. Kg Suture cartridge for meniscal repair
US9730793B2 (en) 2012-12-06 2017-08-15 Valtech Cardio, Ltd. Techniques for guide-wire based advancement of a tool
US9592047B2 (en) 2012-12-21 2017-03-14 Edwards Lifesciences Corporation System for securing sutures
US9113892B2 (en) 2013-01-08 2015-08-25 Covidien Lp Surgical clip applier
US9968362B2 (en) 2013-01-08 2018-05-15 Covidien Lp Surgical clip applier
US9750500B2 (en) 2013-01-18 2017-09-05 Covidien Lp Surgical clip applier
US9681952B2 (en) 2013-01-24 2017-06-20 Mitraltech Ltd. Anchoring of prosthetic valve supports
WO2014134183A1 (en) 2013-02-26 2014-09-04 Mitralign, Inc. Devices and methods for percutaneous tricuspid valve repair
WO2014138570A2 (en) 2013-03-08 2014-09-12 Zone 2 Surgical, Inc. Collapsible locking suture
US10449333B2 (en) 2013-03-14 2019-10-22 Valtech Cardio, Ltd. Guidewire feeder
US9744037B2 (en) 2013-03-15 2017-08-29 California Institute Of Technology Handle mechanism and functionality for repositioning and retrieval of transcatheter heart valves
EP2968847B1 (en) 2013-03-15 2023-03-08 Edwards Lifesciences Corporation Translation catheter systems
US9775624B2 (en) 2013-08-27 2017-10-03 Covidien Lp Surgical clip applier
US10070857B2 (en) 2013-08-31 2018-09-11 Mitralign, Inc. Devices and methods for locating and implanting tissue anchors at mitral valve commissure
US10299793B2 (en) 2013-10-23 2019-05-28 Valtech Cardio, Ltd. Anchor magazine
US10166098B2 (en) 2013-10-25 2019-01-01 Middle Peak Medical, Inc. Systems and methods for transcatheter treatment of valve regurgitation
US9610162B2 (en) 2013-12-26 2017-04-04 Valtech Cardio, Ltd. Implantation of flexible implant
US10390943B2 (en) 2014-03-17 2019-08-27 Evalve, Inc. Double orifice device for transcatheter mitral valve replacement
US9572666B2 (en) 2014-03-17 2017-02-21 Evalve, Inc. Mitral valve fixation device removal devices and methods
CA2903891C (en) 2014-05-30 2021-01-19 Manouchehr A. Miraki Systems for securing sutures
CA2958061A1 (en) 2014-06-18 2015-12-23 Middle Peak Medical, Inc. Mitral valve implants for the treatment of valvular regurgitation
JP6740140B2 (en) 2014-06-24 2020-08-12 ポラレス・メディカル・インコーポレイテッド System and method for securing an implant
WO2016016899A1 (en) 2014-07-30 2016-02-04 Mitraltech Ltd. Articulatable prosthetic valve
WO2016059639A1 (en) 2014-10-14 2016-04-21 Valtech Cardio Ltd. Leaflet-restraining techniques
US10702278B2 (en) 2014-12-02 2020-07-07 Covidien Lp Laparoscopic surgical ligation clip applier
EP3229703A4 (en) 2014-12-10 2018-09-05 Edwards Lifesciences AG Multiple-firing securing device and methods for using and manufacturing same
US10188392B2 (en) 2014-12-19 2019-01-29 Abbott Cardiovascular Systems, Inc. Grasping for tissue repair
WO2016105511A1 (en) 2014-12-24 2016-06-30 Edwards Lifesciences Corporation Suture clip deployment devices
US9931124B2 (en) 2015-01-07 2018-04-03 Covidien Lp Reposable clip applier
WO2016112509A1 (en) 2015-01-15 2016-07-21 Covidien Lp Endoscopic reposable surgical clip applier
US10292712B2 (en) 2015-01-28 2019-05-21 Covidien Lp Surgical clip applier with integrated cutter
US9974651B2 (en) 2015-02-05 2018-05-22 Mitral Tech Ltd. Prosthetic valve with axially-sliding frames
WO2016125160A1 (en) 2015-02-05 2016-08-11 Mitraltech Ltd. Prosthetic valve with axially-sliding frames
US20160256269A1 (en) 2015-03-05 2016-09-08 Mitralign, Inc. Devices for treating paravalvular leakage and methods use thereof
US10159491B2 (en) 2015-03-10 2018-12-25 Covidien Lp Endoscopic reposable surgical clip applier
US10470759B2 (en) 2015-03-16 2019-11-12 Edwards Lifesciences Corporation Suture securement devices
US10524912B2 (en) 2015-04-02 2020-01-07 Abbott Cardiovascular Systems, Inc. Tissue fixation devices and methods
CN111265335B (en) 2015-04-30 2022-03-15 瓦尔泰克卡迪欧有限公司 Valvuloplasty techniques
US10376673B2 (en) 2015-06-19 2019-08-13 Evalve, Inc. Catheter guiding system and methods
US10238494B2 (en) 2015-06-29 2019-03-26 Evalve, Inc. Self-aligning radiopaque ring
US10667815B2 (en) 2015-07-21 2020-06-02 Evalve, Inc. Tissue grasping devices and related methods
US10413408B2 (en) 2015-08-06 2019-09-17 Evalve, Inc. Delivery catheter systems, methods, and devices
WO2017059406A1 (en) 2015-10-01 2017-04-06 Neochord, Inc. Ringless web for repair of heart valves
US10238495B2 (en) 2015-10-09 2019-03-26 Evalve, Inc. Delivery catheter handle and methods of use
US10702279B2 (en) 2015-11-03 2020-07-07 Covidien Lp Endoscopic surgical clip applier
US9592121B1 (en) 2015-11-06 2017-03-14 Middle Peak Medical, Inc. Device, system, and method for transcatheter treatment of valvular regurgitation
EP3373826A4 (en) 2015-11-10 2019-11-06 Covidien LP Endoscopic reposable surgical clip applier
US10390831B2 (en) 2015-11-10 2019-08-27 Covidien Lp Endoscopic reposable surgical clip applier
WO2017079895A1 (en) 2015-11-10 2017-05-18 Covidien Lp Endoscopic reposable surgical clip applier
US10828160B2 (en) 2015-12-30 2020-11-10 Edwards Lifesciences Corporation System and method for reducing tricuspid regurgitation
US10751182B2 (en) 2015-12-30 2020-08-25 Edwards Lifesciences Corporation System and method for reshaping right heart
EP3402417A4 (en) 2016-01-11 2019-12-04 Covidien LP Endoscopic reposable surgical clip applier
CA3011262A1 (en) 2016-01-18 2017-07-27 Covidien Lp Endoscopic surgical clip applier
US10531866B2 (en) 2016-02-16 2020-01-14 Cardiovalve Ltd. Techniques for providing a replacement valve and transseptal communication
CA2958160A1 (en) 2016-02-24 2017-08-24 Covidien Lp Endoscopic reposable surgical clip applier
WO2017156259A1 (en) 2016-03-10 2017-09-14 Lc Therapeutics, Inc. Synthetic chord for cardiac valve repair applications
US10702274B2 (en) 2016-05-26 2020-07-07 Edwards Lifesciences Corporation Method and system for closing left atrial appendage
US10736632B2 (en) 2016-07-06 2020-08-11 Evalve, Inc. Methods and devices for valve clip excision
US10973638B2 (en) 2016-07-07 2021-04-13 Edwards Lifesciences Corporation Device and method for treating vascular insufficiency
GB201611910D0 (en) 2016-07-08 2016-08-24 Valtech Cardio Ltd Adjustable annuloplasty device with alternating peaks and troughs
EP3848003A1 (en) 2016-08-10 2021-07-14 Cardiovalve Ltd. Prosthetic valve with concentric frames
USD800908S1 (en) 2016-08-10 2017-10-24 Mitraltech Ltd. Prosthetic valve element
WO2018027788A1 (en) 2016-08-11 2018-02-15 Covidien Lp Endoscopic surgical clip applier and clip applying systems
AU2016420481A1 (en) 2016-08-25 2019-01-17 Covidien Lp Endoscopic surgical clip applier and clip applying systems
US10939905B2 (en) 2016-08-26 2021-03-09 Edwards Lifesciences Corporation Suture clips, deployment devices therefor, and methods of use
US11071564B2 (en) 2016-10-05 2021-07-27 Evalve, Inc. Cardiac valve cutting device
US10660651B2 (en) 2016-10-31 2020-05-26 Covidien Lp Endoscopic reposable surgical clip applier
US10639044B2 (en) 2016-10-31 2020-05-05 Covidien Lp Ligation clip module and clip applier
US10426489B2 (en) 2016-11-01 2019-10-01 Covidien Lp Endoscopic reposable surgical clip applier
US10610236B2 (en) 2016-11-01 2020-04-07 Covidien Lp Endoscopic reposable surgical clip applier
US10492795B2 (en) 2016-11-01 2019-12-03 Covidien Lp Endoscopic surgical clip applier
US10363138B2 (en) 2016-11-09 2019-07-30 Evalve, Inc. Devices for adjusting the curvature of cardiac valve structures
US10398553B2 (en) 2016-11-11 2019-09-03 Evalve, Inc. Opposing disk device for grasping cardiac valve tissue
US10398552B2 (en) 2016-11-15 2019-09-03 Abbott Cardiovascular Systems Inc. Fixation devices, systems and methods for heart valve leaf repair
US10426616B2 (en) 2016-11-17 2019-10-01 Evalve, Inc. Cardiac implant delivery system
US10779837B2 (en) 2016-12-08 2020-09-22 Evalve, Inc. Adjustable arm device for grasping tissues
US10314586B2 (en) 2016-12-13 2019-06-11 Evalve, Inc. Rotatable device and method for fixing tricuspid valve tissue
US10863980B2 (en) 2016-12-28 2020-12-15 Edwards Lifesciences Corporation Suture fastener having spaced-apart layers
US10709455B2 (en) 2017-02-02 2020-07-14 Covidien Lp Endoscopic surgical clip applier
WO2018141110A1 (en) 2017-02-06 2018-08-09 Covidien Lp Surgical clip applier with user feedback feature
US10758244B2 (en) 2017-02-06 2020-09-01 Covidien Lp Endoscopic surgical clip applier
US10660725B2 (en) 2017-02-14 2020-05-26 Covidien Lp Endoscopic surgical clip applier including counter assembly
US10603038B2 (en) 2017-02-22 2020-03-31 Covidien Lp Surgical clip applier including inserts for jaw assembly
US10548602B2 (en) 2017-02-23 2020-02-04 Covidien Lp Endoscopic surgical clip applier
US11583291B2 (en) 2017-02-23 2023-02-21 Covidien Lp Endoscopic surgical clip applier
US10478303B2 (en) 2017-03-13 2019-11-19 Polares Medical Inc. Device, system, and method for transcatheter treatment of valvular regurgitation
JP7159230B2 (en) 2017-03-13 2022-10-24 ポラレス・メディカル・インコーポレイテッド Devices, systems and methods for transcatheter treatment of valvular regurgitation
US10653524B2 (en) 2017-03-13 2020-05-19 Polares Medical Inc. Device, system, and method for transcatheter treatment of valvular regurgitation
US10213306B2 (en) 2017-03-31 2019-02-26 Neochord, Inc. Minimally invasive heart valve repair in a beating heart
US11045627B2 (en) 2017-04-18 2021-06-29 Edwards Lifesciences Corporation Catheter system with linear actuation control mechanism
US10675043B2 (en) 2017-05-04 2020-06-09 Covidien Lp Reposable multi-fire surgical clip applier
US10722235B2 (en) 2017-05-11 2020-07-28 Covidien Lp Spring-release surgical clip
US11065119B2 (en) 2017-05-12 2021-07-20 Evalve, Inc. Long arm valve repair clip
US10639032B2 (en) 2017-06-30 2020-05-05 Covidien Lp Endoscopic surgical clip applier including counter assembly
US10660723B2 (en) 2017-06-30 2020-05-26 Covidien Lp Endoscopic reposable surgical clip applier
US11246704B2 (en) 2017-08-03 2022-02-15 Cardiovalve Ltd. Prosthetic heart valve
US10575948B2 (en) 2017-08-03 2020-03-03 Cardiovalve Ltd. Prosthetic heart valve
US10888421B2 (en) 2017-09-19 2021-01-12 Cardiovalve Ltd. Prosthetic heart valve with pouch
US11793633B2 (en) 2017-08-03 2023-10-24 Cardiovalve Ltd. Prosthetic heart valve
US10537426B2 (en) 2017-08-03 2020-01-21 Cardiovalve Ltd. Prosthetic heart valve
US10675112B2 (en) 2017-08-07 2020-06-09 Covidien Lp Endoscopic surgical clip applier including counter assembly
US10932790B2 (en) 2017-08-08 2021-03-02 Covidien Lp Geared actuation mechanism and surgical clip applier including the same
US10863992B2 (en) 2017-08-08 2020-12-15 Covidien Lp Endoscopic surgical clip applier
US10786262B2 (en) 2017-08-09 2020-09-29 Covidien Lp Endoscopic reposable surgical clip applier
US10786263B2 (en) 2017-08-15 2020-09-29 Covidien Lp Endoscopic reposable surgical clip applier
US10835341B2 (en) 2017-09-12 2020-11-17 Covidien Lp Endoscopic surgical clip applier and handle assemblies for use therewith
US10653429B2 (en) 2017-09-13 2020-05-19 Covidien Lp Endoscopic surgical clip applier
US10758245B2 (en) 2017-09-13 2020-09-01 Covidien Lp Clip counting mechanism for surgical clip applier
US10835260B2 (en) 2017-09-13 2020-11-17 Covidien Lp Endoscopic surgical clip applier and handle assemblies for use therewith
US10835221B2 (en) 2017-11-02 2020-11-17 Valtech Cardio, Ltd. Implant-cinching devices and systems
US11376015B2 (en) 2017-11-03 2022-07-05 Covidien Lp Endoscopic surgical clip applier and handle assemblies for use therewith
US11116513B2 (en) 2017-11-03 2021-09-14 Covidien Lp Modular surgical clip cartridge
US10945734B2 (en) 2017-11-03 2021-03-16 Covidien Lp Rotation knob assemblies and surgical instruments including the same
US10828036B2 (en) 2017-11-03 2020-11-10 Covidien Lp Endoscopic surgical clip applier and handle assemblies for use therewith
US10932791B2 (en) 2017-11-03 2021-03-02 Covidien Lp Reposable multi-fire surgical clip applier
US10624631B1 (en) 2017-11-13 2020-04-21 Simon B. Rayhanabad Surgical suture and method of suturing
US11135062B2 (en) 2017-11-20 2021-10-05 Valtech Cardio Ltd. Cinching of dilated heart muscle
US10722236B2 (en) 2017-12-12 2020-07-28 Covidien Lp Endoscopic reposable surgical clip applier
GB201720803D0 (en) 2017-12-13 2018-01-24 Mitraltech Ltd Prosthetic Valve and delivery tool therefor
US10849630B2 (en) 2017-12-13 2020-12-01 Covidien Lp Reposable multi-fire surgical clip applier
US10959737B2 (en) 2017-12-13 2021-03-30 Covidien Lp Reposable multi-fire surgical clip applier
US10743887B2 (en) 2017-12-13 2020-08-18 Covidien Lp Reposable multi-fire surgical clip applier
GB201800399D0 (en) 2018-01-10 2018-02-21 Mitraltech Ltd Temperature-control during crimping of an implant
US11051827B2 (en) 2018-01-16 2021-07-06 Covidien Lp Endoscopic surgical instrument and handle assemblies for use therewith
CN111655200B (en) 2018-01-24 2023-07-14 爱德华兹生命科学创新(以色列)有限公司 Contraction of annuloplasty structures
EP4248904A3 (en) 2018-01-26 2023-11-29 Edwards Lifesciences Innovation (Israel) Ltd. Techniques for facilitating heart valve tethering and chord replacement
EP3768176B1 (en) 2018-03-23 2024-03-20 NeoChord, Inc. Device for suture attachment for minimally invasive heart valve repair
US10993721B2 (en) 2018-04-25 2021-05-04 Covidien Lp Surgical clip applier
US11253360B2 (en) 2018-05-09 2022-02-22 Neochord, Inc. Low profile tissue anchor for minimally invasive heart valve repair
US11173030B2 (en) 2018-05-09 2021-11-16 Neochord, Inc. Suture length adjustment for minimally invasive heart valve repair
WO2020012481A2 (en) 2018-07-12 2020-01-16 Valtech Cardio, Ltd. Annuloplasty systems and locking tools therefor
US10786273B2 (en) 2018-07-13 2020-09-29 Covidien Lp Rotation knob assemblies for handle assemblies
US11259887B2 (en) 2018-08-10 2022-03-01 Covidien Lp Feedback mechanisms for handle assemblies
US11033256B2 (en) 2018-08-13 2021-06-15 Covidien Lp Linkage assembly for reusable surgical handle assemblies
US11219463B2 (en) 2018-08-13 2022-01-11 Covidien Lp Bilateral spring for surgical instruments and surgical instruments including the same
US11246601B2 (en) 2018-08-13 2022-02-15 Covidien Lp Elongated assemblies for surgical clip appliers and surgical clip appliers incorporating the same
US11278267B2 (en) 2018-08-13 2022-03-22 Covidien Lp Latch assemblies and surgical instruments including the same
US11344316B2 (en) 2018-08-13 2022-05-31 Covidien Lp Elongated assemblies for surgical clip appliers and surgical clip appliers incorporating the same
US11253267B2 (en) 2018-08-13 2022-02-22 Covidien Lp Friction reduction mechanisms for handle assemblies
US11051828B2 (en) 2018-08-13 2021-07-06 Covidien Lp Rotation knob assemblies and surgical instruments including same
US10966709B2 (en) 2018-09-07 2021-04-06 Neochord, Inc. Device for suture attachment for minimally invasive heart valve repair
US10874850B2 (en) 2018-09-28 2020-12-29 Medtronic, Inc. Impedance-based verification for delivery of implantable medical devices
US11147566B2 (en) 2018-10-01 2021-10-19 Covidien Lp Endoscopic surgical clip applier
US11524398B2 (en) 2019-03-19 2022-12-13 Covidien Lp Gear drive mechanisms for surgical instruments
WO2020214818A1 (en) 2019-04-16 2020-10-22 Neochord, Inc. Transverse helical cardiac anchor for minimally invasive heart valve repair
US11331475B2 (en) 2019-05-07 2022-05-17 Medtronic, Inc. Tether assemblies for medical device delivery systems
US11534303B2 (en) 2020-04-09 2022-12-27 Evalve, Inc. Devices and systems for accessing and repairing a heart valve
JP2022541221A (en) 2019-07-15 2022-09-22 エバルブ,インコーポレイティド Wide clip with non-deforming wings
EP3998993A1 (en) 2019-07-15 2022-05-25 Evalve, Inc. Proximal element actuator fixation and release mechanisms
EP4033970A1 (en) 2019-09-26 2022-08-03 Evalve, Inc. Systems for intra-procedural cardiac pressure monitoring
US11464636B2 (en) 2019-10-11 2022-10-11 Evalve, Inc. Repair clip for variable tissue thickness
EP4193934A1 (en) 2019-10-29 2023-06-14 Edwards Lifesciences Innovation (Israel) Ltd. Annuloplasty and tissue anchor technologies
WO2021092460A1 (en) 2019-11-08 2021-05-14 Evalve, Inc. Medical device delivery system with locking system
WO2021097124A1 (en) 2019-11-14 2021-05-20 Evalve, Inc. Catheter assembly with coaptation aid and methods for valve repair
WO2021097089A1 (en) 2019-11-14 2021-05-20 Evalve, Inc. Kit with coaptation aid and fixation system and methods for valve repair
US11779340B2 (en) 2020-01-02 2023-10-10 Covidien Lp Ligation clip loading device
US11723669B2 (en) 2020-01-08 2023-08-15 Covidien Lp Clip applier with clip cartridge interface
US11464634B2 (en) 2020-12-16 2022-10-11 Polares Medical Inc. Device, system, and method for transcatheter treatment of valvular regurgitation with secondary anchors
US11759321B2 (en) 2021-06-25 2023-09-19 Polares Medical Inc. Device, system, and method for transcatheter treatment of valvular regurgitation
CN114587486B (en) * 2022-03-20 2023-11-10 郑州大学第一附属医院 Reinforced fixing double-arm anastomosis clamp device for endoscope

Citations (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1087186A (en) * 1909-03-22 1914-02-17 Socrates Scholfield Illustrative educational device.
US1167014A (en) * 1915-06-25 1916-01-04 William R O'brien Veterinary surgical instrument.
US3082426A (en) * 1960-06-17 1963-03-26 George Oliver Halsted Surgical stapling device
US3570497A (en) * 1969-01-16 1971-03-16 Gerald M Lemole Suture apparatus and methods
US3638654A (en) * 1969-07-11 1972-02-01 Uche Akuba Suturing instrument
US4006747A (en) * 1975-04-23 1977-02-08 Ethicon, Inc. Surgical method
US4073179A (en) * 1976-06-01 1978-02-14 Codman & Shurtleff, Inc. Clip removing device
US4140125A (en) * 1976-02-25 1979-02-20 Med-Pro, Ltd. Surgical tape device
US4185636A (en) * 1977-12-29 1980-01-29 Albert Einstein College Of Medicine Of Yeshiva University Suture organizer, prosthetic device holder, and related surgical procedures
US4192315A (en) * 1976-12-23 1980-03-11 Aesculap-Werke Aktiengesellschaft Vormals Jetter & Scheerer Clip for surgical purposes
US4243048A (en) * 1976-09-21 1981-01-06 Jim Zegeer Biopsy device
US4366819A (en) * 1980-11-17 1983-01-04 Kaster Robert L Anastomotic fitting
US4492229A (en) * 1982-09-03 1985-01-08 Grunwald Ronald P Suture guide holder
US4576605A (en) * 1985-03-01 1986-03-18 Nauchno-Issledovatelsky Institut Khirurgii Imeni A.V. Vishnevskogo Cardiac valve prosthesis
US4637380A (en) * 1985-06-24 1987-01-20 Orejola Wilmo C Surgical wound closures
US4641652A (en) * 1984-04-12 1987-02-10 Richard Wolf Gmbh Applicator for tying sewing threads
US4653496A (en) * 1985-02-01 1987-03-31 Bundy Mark A Transluminal lysing system
US4719924A (en) * 1986-09-09 1988-01-19 C. R. Bard, Inc. Small diameter steerable guidewire with adjustable tip
US4719917A (en) * 1987-02-17 1988-01-19 Minnesota Mining And Manufacturing Company Surgical staple
US4730615A (en) * 1986-03-03 1988-03-15 Pfizer Hospital Products Group, Inc. Sternum closure device
US4732151A (en) * 1986-10-08 1988-03-22 Patent Research & Development Corp. Low trauma suturing
US4809695A (en) * 1981-10-21 1989-03-07 Owen M. Gwathmey Suturing assembly and method
US4890615A (en) * 1987-11-05 1990-01-02 Concept, Inc. Arthroscopic suturing instrument
US4896668A (en) * 1986-04-10 1990-01-30 Peters Plate set for osteal fixation, equipped with suture strands
US4899744A (en) * 1988-12-15 1990-02-13 Tatsuo Fujitsuka Apparatus for anastomosing digestive tract
US4901721A (en) * 1988-08-02 1990-02-20 Hakki Samir I Suturing device
US4983176A (en) * 1989-03-06 1991-01-08 University Of New Mexico Deformable plastic surgical clip
US4990152A (en) * 1988-10-12 1991-02-05 Inbae Yoon Applicator device housing multiple elastic ligatures in series and for dilating and applying elastic ligatures onto anatomical tissue
US4991567A (en) * 1990-01-16 1991-02-12 Mccuen Ii Brooks W Micro-iris retractor
US4994069A (en) * 1988-11-02 1991-02-19 Target Therapeutics Vaso-occlusion coil and method
US4997439A (en) * 1989-01-26 1991-03-05 Chen Fusen H Surgical closure or anastomotic device
US5002562A (en) * 1988-06-03 1991-03-26 Oberlander Michael A Surgical clip
US5002563A (en) * 1990-02-22 1991-03-26 Raychem Corporation Sutures utilizing shape memory alloys
US5002550A (en) * 1989-06-06 1991-03-26 Mitek Surgical Products, Inc. Suture anchor installation tool
US5088692A (en) * 1990-09-04 1992-02-18 Weiler Raywood C Heavy duty staple remover
US5178634A (en) * 1989-03-31 1993-01-12 Wilson Ramos Martinez Aortic valved tubes for human implants
US5282825A (en) * 1993-06-02 1994-02-01 Muck Kin C Surgical ligaturing and animal restraining device
US5382259A (en) * 1992-10-26 1995-01-17 Target Therapeutics, Inc. Vasoocclusion coil with attached tubular woven or braided fibrous covering
US5383904A (en) * 1992-10-13 1995-01-24 United States Surgical Corporation Stiffened surgical device
US5387227A (en) * 1992-09-10 1995-02-07 Grice; O. Drew Method for use of a laparo-suture needle
US5480405A (en) * 1987-05-14 1996-01-02 Yoon; Inbae Anchor applier instrument for use in suturing tissue
US5486187A (en) * 1994-01-04 1996-01-23 Schenck; Robert R. Anastomosis device and method
US5486197A (en) * 1994-03-24 1996-01-23 Ethicon, Inc. Two-piece suture anchor with barbs
US5488958A (en) * 1992-11-09 1996-02-06 Vance Products Incorporated Surgical cutting instrument for coring tissue affixed thereto
US5591179A (en) * 1995-04-19 1997-01-07 Applied Medical Resources Corporation Anastomosis suturing device and method
US5593424A (en) * 1994-08-10 1997-01-14 Segmed, Inc. Apparatus and method for reducing and stabilizing the circumference of a vascular structure
US5593414A (en) * 1993-08-25 1997-01-14 Apollo Camera, L.L.C. Method of applying a surgical ligation clip
US5597378A (en) * 1983-10-14 1997-01-28 Raychem Corporation Medical devices incorporating SIM alloy elements
US5601571A (en) * 1994-05-17 1997-02-11 Moss; Gerald Surgical fastener implantation device
US5601572A (en) * 1989-08-16 1997-02-11 Raychem Corporation Device or apparatus for manipulating matter having a elastic ring clip
US5601600A (en) * 1995-09-08 1997-02-11 Conceptus, Inc. Endoluminal coil delivery system having a mechanical release mechanism
US5603718A (en) * 1994-03-31 1997-02-18 Terumo Kabushiki Kaisha Suturing device
US5707380A (en) * 1996-07-23 1998-01-13 United States Surgical Corporation Anastomosis instrument and method
US5707362A (en) * 1992-04-15 1998-01-13 Yoon; Inbae Penetrating instrument having an expandable anchoring portion for triggering protrusion of a safety member and/or retraction of a penetrating member
US5709693A (en) * 1996-02-20 1998-01-20 Cardiothoracic System, Inc. Stitcher
US5716370A (en) * 1996-02-23 1998-02-10 Williamson, Iv; Warren Means for replacing a heart valve in a minimally invasive manner
US5715987A (en) * 1994-04-05 1998-02-10 Tracor Incorporated Constant width, adjustable grip, staple apparatus and method
US5720755A (en) * 1995-01-18 1998-02-24 Dakov; Pepi Tubular suturing device and methods of use
US5855614A (en) * 1993-02-22 1999-01-05 Heartport, Inc. Method and apparatus for thoracoscopic intracardiac procedures
US5868702A (en) * 1991-07-16 1999-02-09 Heartport, Inc. System for cardiac procedures
US5868763A (en) * 1996-09-16 1999-02-09 Guidant Corporation Means and methods for performing an anastomosis
US5871528A (en) * 1996-06-28 1999-02-16 Medtronic, Inc. Temporary bipolar heart wire
US6010531A (en) * 1993-02-22 2000-01-04 Heartport, Inc. Less-invasive devices and methods for cardiac valve surgery
US6013084A (en) * 1995-06-30 2000-01-11 Target Therapeutics, Inc. Stretch resistant vaso-occlusive coils (II)
US6022367A (en) * 1997-06-18 2000-02-08 United States Surgical Surgical apparatus for forming a hole in a blood vessel
US6024748A (en) * 1996-07-23 2000-02-15 United States Surgical Corporation Singleshot anastomosis instrument with detachable loading unit and method
US6171320B1 (en) * 1996-12-25 2001-01-09 Niti Alloys Technologies Ltd. Surgical clip
US6171321B1 (en) * 1995-02-24 2001-01-09 Heartport, Inc. Devices and methods for performing a vascular anastomosis
US6176413B1 (en) * 1994-06-17 2001-01-23 Heartport, Inc. Surgical anastomosis apparatus and method thereof
US6176864B1 (en) * 1998-03-09 2001-01-23 Corvascular, Inc. Anastomosis device and method
US6179848B1 (en) * 1996-07-24 2001-01-30 Jan Otto Solem Anastomotic fitting
US6179840B1 (en) * 1999-07-23 2001-01-30 Ethicon, Inc. Graft fixation device and method
US6179849B1 (en) * 1999-06-10 2001-01-30 Vascular Innovations, Inc. Sutureless closure for connecting a bypass graft to a target vessel
US6183512B1 (en) * 1999-04-16 2001-02-06 Edwards Lifesciences Corporation Flexible annuloplasty system
US6190373B1 (en) * 1992-11-13 2001-02-20 Scimed Life Systems, Inc. Axially detachable embolic coil assembly
US6193734B1 (en) * 1998-01-23 2001-02-27 Heartport, Inc. System for performing vascular anastomoses
US6193733B1 (en) * 1997-06-20 2001-02-27 Boston Scientific Corporation Hemostatic clips
US20020010490A1 (en) * 1999-03-01 2002-01-24 Laurent Schaller Tissue connector apparatus and methods
US6346074B1 (en) * 1993-02-22 2002-02-12 Heartport, Inc. Devices for less invasive intracardiac interventions
US6350269B1 (en) * 1999-03-01 2002-02-26 Apollo Camera, L.L.C. Ligation clip and clip applier
US6514265B2 (en) * 1999-03-01 2003-02-04 Coalescent Surgical, Inc. Tissue connector apparatus with cable release
US6517558B2 (en) * 1999-01-15 2003-02-11 Ventrica, Inc. Methods and devices for forming vascular anastomoses
US6524338B1 (en) * 2000-08-25 2003-02-25 Steven R. Gundry Method and apparatus for stapling an annuloplasty band in-situ
US6682540B1 (en) * 1999-11-05 2004-01-27 Onux Medical, Inc. Apparatus and method for placing multiple sutures
US6695859B1 (en) * 1999-04-05 2004-02-24 Coalescent Surgical, Inc. Apparatus and methods for anastomosis
US20050004582A1 (en) * 2002-12-16 2005-01-06 Edoga John K. Endovascular stapler
US20050021054A1 (en) * 2003-07-25 2005-01-27 Coalescent Surgical, Inc. Sealing clip, delivery systems, and methods
US20050043749A1 (en) * 2003-08-22 2005-02-24 Coalescent Surgical, Inc. Eversion apparatus and methods
US20060004389A1 (en) * 1998-06-03 2006-01-05 Medtronic, Inc. Multiple loop tissue connector apparatus and methods
US20070027461A1 (en) * 1998-06-03 2007-02-01 Barry Gardiner Tissue connector apparatus and methods
US7335212B2 (en) * 2002-12-16 2008-02-26 Edrich Vascular Devices, Inc. Multiple stapling device for narrow blood vessels
US7335213B1 (en) * 2002-11-15 2008-02-26 Abbott Cardiovascular Systems Inc. Apparatus and methods for heart valve repair
US20090036903A1 (en) * 2007-05-05 2009-02-05 Arbor Surgical Technologies, Inc. Apparatus and methods for delivering fasteners during valve replacement
US20100044410A1 (en) * 2008-08-22 2010-02-25 Medtronic, Inc. Endovascular Stapling Apparatus and Methods of Use

Family Cites Families (470)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2715486A (en) 1955-08-16 Fast-threading needls with trailing flexible link
US43098A (en) 1864-06-14 Improvement in suture-instruments
US636728A (en) 1899-05-24 1899-11-07 George J Kindel Tape-needle.
US655190A (en) 1899-11-27 1900-08-07 Louis Bramson Suturating instrument.
FR320731A (en) 1902-04-28 1902-12-18 Brown Haydn Crampon for surgical operations and pliers for use
US1539221A (en) 1923-10-30 1925-05-26 Tennant John William Welder's rod holder
US1583271A (en) 1925-01-14 1926-05-04 Biro Ladislaus Surgical instrument
US1625602A (en) 1926-04-06 1927-04-19 Harold G Gould Surgical appliance
US1867624A (en) 1930-04-01 1932-07-19 Memorial Hospital For The Trea Device for obtaining biopsy specimens
US2201610A (en) 1938-05-20 1940-05-21 Jr James C Dawson Wound clip
US2240330A (en) 1938-07-11 1941-04-29 Andrew B Flagg Surgical needle or the like
US2256382A (en) 1939-03-06 1941-09-16 Edward H Kruse Surgical ligature applicator
US2264679A (en) 1940-10-29 1941-12-02 Ravel Vincent Marvin Surgical instrument
US2430293A (en) 1944-10-21 1947-11-04 John N M Howells Means for applying fastening devices
US2413142A (en) 1945-06-11 1946-12-24 Edwin M Jones Suturing assembly and method
US2516710A (en) 1947-05-12 1950-07-25 Delfino P Mascolo Double point surgical needle
US2505358A (en) 1949-04-20 1950-04-25 Sklar Mfg Co Inc J Double-cutting biopsy bistoury
US2890519A (en) 1955-08-01 1959-06-16 Storz Instr Co Surgical spring clip forceps
US2940452A (en) 1958-11-07 1960-06-14 Ca Nat Research Council Vascular evertor
US3055689A (en) 1960-06-29 1962-09-25 Clarence H Jorgensen Holding device for doors and the like
US3057355A (en) 1960-07-08 1962-10-09 Canadian Patents Dev Vascular everter
US3150379A (en) 1962-03-01 1964-09-29 Ernest C Wood Single clip disposable applicator
US3143742A (en) 1963-03-19 1964-08-11 Surgitool Inc Prosthetic sutureless heart valve
US3180337A (en) 1963-04-25 1965-04-27 Ca Nat Research Council Vascular everting device
US3249104A (en) 1963-06-21 1966-05-03 George J Hohnstein Surgical needle
GB1021589A (en) 1963-12-05 1966-03-02 Down Brothers And Mayer And Ph Improvements in and relating to clamping devices
US3547103A (en) 1965-10-29 1970-12-15 William A Cook Coil spring guide
US3452740A (en) 1966-05-31 1969-07-01 Us Catheter & Instr Corp Spring guide manipulator
US3506012A (en) 1967-08-01 1970-04-14 Ivan E Brown Polyp clamp and applier therefor
US3509882A (en) 1967-09-18 1970-05-05 American Hospital Supply Corp Parallel jaw spring clip and applicator
NL143127B (en) 1969-02-04 1974-09-16 Rhone Poulenc Sa REINFORCEMENT DEVICE FOR A DEFECTIVE HEART VALVE.
US3608095A (en) 1970-03-05 1971-09-28 Federal Tool Eng Co Method of fixing hair pieces to scalps
USRE27391E (en) 1970-10-12 1972-06-20 Connector for holding articles together
US3802438A (en) 1972-03-31 1974-04-09 Technibiotics Surgical instrument
US3753438A (en) 1972-04-25 1973-08-21 E Wood Suture clip
US3776237A (en) 1972-05-11 1973-12-04 Tecna Corp Surgical tool and method of providing a surgical opening
US3762418A (en) 1972-05-17 1973-10-02 W Wasson Surgical suture
US3874388A (en) 1973-02-12 1975-04-01 Ochsner Med Found Alton Shunt defect closure system
US3825009A (en) 1973-03-19 1974-07-23 J Williams Method of surgically repairing damaged ear drums
US3875648A (en) 1973-04-04 1975-04-08 Dennison Mfg Co Fastener attachment apparatus and method
GB1413191A (en) 1973-07-04 1975-11-12 Vnii Khirurgicheskoi Apparatur Device for the eversion of hollow organs and vascular stapling instrument incorporating same
US3837345A (en) 1973-08-31 1974-09-24 A Matar Venous valve snipper
US3910281A (en) 1973-10-09 1975-10-07 Bio Medicus Inc Suture anchor
JPS5320957Y2 (en) 1973-11-14 1978-06-01
US3905403A (en) 1973-12-26 1975-09-16 Kuhlman Corp Methods of manufacturing dual interlocked safety spring assemblies
US3976079A (en) 1974-08-01 1976-08-24 Samuels Peter B Securing devices for sutures
US4129059A (en) 1974-11-07 1978-12-12 Eck William F Van Staple-type fastener
US4018228A (en) 1975-02-24 1977-04-19 Goosen Carl C Surgical punch apparatus
US4038725A (en) 1975-03-20 1977-08-02 Monarch Marking Systems, Inc. Fastener and method of using same
SU566574A1 (en) 1975-05-04 1977-07-30 Всесоюзный научно-исследовательский и испытательный институт медицинской техники Apparatus for applying linear agraffe suture on organs and tissue
US3995619A (en) 1975-10-14 1976-12-07 Glatzer Stephen G Combination subcutaneous suture remover, biopsy sampler and syringe
SU577022A1 (en) 1976-06-25 1977-10-30 Всесоюзный Научно-Исследовательский Институт Клинической И Экспериментальной Хирургии Cardiac valve prosthesis
US4042979A (en) 1976-07-12 1977-08-23 Angell William W Valvuloplasty ring and prosthetic method
US4170990A (en) 1977-01-28 1979-10-16 Fried. Krupp Gesellschaft Mit Beschrankter Haftung Method for implanting and subsequently removing mechanical connecting elements from living tissue
DE2703529A1 (en) 1977-01-28 1978-08-03 Krupp Gmbh IMPLANT TO CONNECT SEPARATION SITES IN LIVING TISSUE
US4103690A (en) 1977-03-21 1978-08-01 Cordis Corporation Self-suturing cardiac pacer lead
US4217902A (en) 1977-05-02 1980-08-19 March Alfred L Hemostatic clip
US4214587A (en) 1979-02-12 1980-07-29 Sakura Chester Y Jr Anastomosis device and method
US4352358A (en) 1979-12-28 1982-10-05 Angelchik Jean P Apparatus for effecting anastomotic procedures
US4396139A (en) 1980-02-15 1983-08-02 Technalytics, Inc. Surgical stapling system, apparatus and staple
US4345601A (en) 1980-04-07 1982-08-24 Mamoru Fukuda Continuous suturing device
US4324248A (en) 1980-05-30 1982-04-13 Metatech Corporation Microsurgical clip
US4522207A (en) 1981-02-06 1985-06-11 Charles H. Klieman Spring activated hemostatic clip applicator
DD158084A1 (en) 1981-05-08 1982-12-29 Joachim Heinke CLOSURE BODY AND METHOD FOR ITS MANUFACTURE
US4416266A (en) 1981-05-15 1983-11-22 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Medical clip
US4485816A (en) 1981-06-25 1984-12-04 Alchemia Shape-memory surgical staple apparatus and method for use in surgical suturing
AU8679382A (en) 1981-08-10 1983-02-17 Ethicon Inc. Polyolefin surgical device
US4465071A (en) 1981-10-26 1984-08-14 Samuels Peter B Method of applying skin clips
US4586502A (en) 1982-02-03 1986-05-06 Ethicon, Inc. Surgical instrument actuator with non-collinear hydraulic pistons
US4624255A (en) 1982-02-18 1986-11-25 Schenck Robert R Apparatus for anastomosing living vessels
US4474181A (en) 1982-02-18 1984-10-02 Schenck Robert R Method and apparatus for anastomosing small blood vessels
DE3227984C2 (en) 1982-07-27 1985-10-17 Abdoll-Hossein Dr. med. 4330 Mülheim Towfigh Device for producing a tendon butt seam
US4470533A (en) 1982-08-13 1984-09-11 Ethicon, Inc. Surgical instrument for suturing tissues and organs
US4470415A (en) 1982-08-19 1984-09-11 The Johns Hopkins University Sutureless vascular anastomosis means and method
US4456017A (en) 1982-11-22 1984-06-26 Cordis Corporation Coil spring guide with deflectable tip
SU1186199A1 (en) 1983-02-15 1985-10-23 Tyumenskij Med I Method of making anastomoses
JPS59168848A (en) 1983-03-11 1984-09-22 エチコン・インコ−ポレ−テツド Antiseptic surgical apparatus made of nonmetal having affinity to organism
US4595007A (en) 1983-03-14 1986-06-17 Ethicon, Inc. Split ring type tissue fastener
US4535764A (en) 1983-04-15 1985-08-20 Tayco Developments, Inc. Surgical bone tie
US4523592A (en) 1983-04-25 1985-06-18 Rollin K. Daniel P.S.C. Anastomotic coupling means capable of end-to-end and end-to-side anastomosis
US4532927A (en) 1983-06-20 1985-08-06 Ethicon, Inc. Two-piece tissue fastener with non-reentry bent leg staple and retaining receiver
US4573469A (en) 1983-06-20 1986-03-04 Ethicon, Inc. Two-piece tissue fastener with coinable leg staple and retaining receiver and method and instrument for applying same
US4548202A (en) 1983-06-20 1985-10-22 Ethicon, Inc. Mesh tissue fasteners
EP0140557A3 (en) 1983-09-12 1986-09-03 Edward Lee Blackwood Surgical instrument
DE3335985C2 (en) 1983-10-04 1986-12-04 Aesculap-Werke Ag Vormals Jetter & Scheerer, 7200 Tuttlingen Magazine for holding C-shaped scalp clips
US4665906A (en) 1983-10-14 1987-05-19 Raychem Corporation Medical devices incorporating sim alloy elements
US4586503A (en) 1983-12-01 1986-05-06 University Of New Mexico Surgical microclip
US4929240A (en) 1983-12-01 1990-05-29 University Of New Mexico Surgical clip and applier
DE3504202A1 (en) 1984-02-07 1985-08-29 Michael M. Dr. 2000 Wedel Schikorski Ligation material for ligating tubular organs in human or animal bodies during surgical interventions
US4549545A (en) 1984-03-05 1985-10-29 Ethicon Inc. Segmented polyurethane surgical buttressing pledgets
US4873975A (en) 1984-04-10 1989-10-17 Walsh Manufacturing (Mississauga) Limited Anastomosis device and method
US6106538A (en) 1984-05-14 2000-08-22 Shiber; Samuel Method for forming an internal coronary bypass
US4932955A (en) 1984-06-29 1990-06-12 Baxter International Inc. Clip
US4706362A (en) 1984-09-25 1987-11-17 Monarch Marking Systems, Inc. Method of attaching tags
US4665917A (en) 1985-01-28 1987-05-19 Ethicon, Inc. Tissue gripper for use with intraluminal stapling device
US4593693A (en) 1985-04-26 1986-06-10 Schenck Robert R Methods and apparatus for anastomosing living vessels
US4683895A (en) 1985-07-25 1987-08-04 Cordis Corporation Suture sleeve anchoring device
US4622970A (en) 1985-08-29 1986-11-18 The Johns Hopkins University Vascular everting instrument
SU1456109A1 (en) 1986-07-23 1989-02-07 Сибирский физико-технический институт им.В.Д.Кузнецова при Томском государственном университете Arrangement for bringing together the wound edges
US5258011A (en) 1987-01-12 1993-11-02 Drews Robert C Corneal rivet
US5119983A (en) 1987-05-26 1992-06-09 United States Surgical Corporation Surgical stapler apparatus
US5366459A (en) 1987-05-14 1994-11-22 Inbae Yoon Surgical clip and clip application procedures
US5100418A (en) * 1987-05-14 1992-03-31 Inbae Yoon Suture tie device system and applicator therefor
US5171250A (en) 1987-05-14 1992-12-15 Inbae Yoon Surgical clips and surgical clip applicator and cutting and transection device
US4957498A (en) 1987-11-05 1990-09-18 Concept, Inc. Suturing instrument
US4820298A (en) 1987-11-20 1989-04-11 Leveen Eric G Internal vascular prosthesis
US4968315A (en) 1987-12-15 1990-11-06 Mitek Surgical Products, Inc. Suture anchor and suture anchor installation tool
US5084057A (en) 1989-07-18 1992-01-28 United States Surgical Corporation Apparatus and method for applying surgical clips in laparoscopic or endoscopic procedures
JP2561853B2 (en) 1988-01-28 1996-12-11 株式会社ジェイ・エム・エス Shaped memory molded article and method of using the same
US4926860A (en) 1988-02-05 1990-05-22 Flexmedics Corporation ARthroscopic instrumentation and method
US5154189A (en) 1988-06-03 1992-10-13 Oberlander Michael A Method for repairing a torn meniscus
SU1560133A1 (en) 1988-07-11 1990-04-30 Сибирский Физико-Технический Институт При Томском Государственном Университете Им.В.В.Куйбышева Device for connecting lips of wound
GB2223410A (en) 1988-08-31 1990-04-11 Fixit Surgical device for wound closure and retraction
US4844318A (en) 1988-09-06 1989-07-04 Kunreuther Steven J Needle assembly
US5047047A (en) 1988-10-26 1991-09-10 Inbae Yoon Wound closing device
US4924866A (en) 1988-10-26 1990-05-15 Inbae Yoon Wound-closing device
FR2640131B1 (en) * 1988-12-12 1991-03-29 Ethnor LIGATURE ASSEMBLY FOR ENDOSCOPIC SURGERY, LIGATURE AND LIGATURE HANDLING INSTRUMENT FOR SUCH ASSEMBLY
US4950283A (en) 1988-12-29 1990-08-21 John Lezdey Surgical clip
US4950015A (en) 1989-01-23 1990-08-21 Design Specialties Laboratories, Inc. Syringe cap clamp tool
US5336233A (en) 1989-01-26 1994-08-09 Chen Fusen H Anastomotic device
EP0595791B1 (en) 1989-02-13 1999-06-30 Baxter International Inc. Anuloplasty ring prosthesis
US4930674A (en) 1989-02-24 1990-06-05 Abiomed, Inc. Surgical stapler
US5007920A (en) 1989-03-24 1991-04-16 Torre Randall J Tendon sectioning support clamp
US5192294A (en) * 1989-05-02 1993-03-09 Blake Joseph W Iii Disposable vascular punch
US5020713A (en) 1989-05-04 1991-06-04 Kunreuther Steven J Assembly of attachments and device for attaching same
US5053047A (en) 1989-05-16 1991-10-01 Inbae Yoon Suture devices particularly useful in endoscopic surgery and methods of suturing
US5222976A (en) 1989-05-16 1993-06-29 Inbae Yoon Suture devices particularly useful in endoscopic surgery
US5074874A (en) 1989-05-16 1991-12-24 Inbae Yoon Suture devices particularly useful in endoscopic surgery
US5011481A (en) 1989-07-17 1991-04-30 Medtronic, Inc. Holder for annuloplasty ring
US5290300A (en) 1989-07-31 1994-03-01 Baxter International Inc. Flexible suture guide and holder
US5350420A (en) 1989-07-31 1994-09-27 Baxter International Inc. Flexible annuloplasty ring and holder
US4935027A (en) 1989-08-21 1990-06-19 Inbae Yoon Surgical suture instrument with remotely controllable suture material advancement
US4950285A (en) 1989-11-27 1990-08-21 Wilk Peter J Suture device
US5123913A (en) 1989-11-27 1992-06-23 Wilk Peter J Suture device
US5026379A (en) 1989-12-05 1991-06-25 Inbae Yoon Multi-functional instruments and stretchable ligating and occluding devices
CA2029671A1 (en) 1989-12-11 1991-06-12 Paul M. Vernon Grip surgical clip
US5222961A (en) 1989-12-26 1993-06-29 Naomi Nakao Endoscopic stapling device and related staple
IT1238173B (en) 1990-01-15 1993-07-09 FOUR-TWO-TWO-TWO-CONVERGENT METAL STITCH SUITABLE FOR CONTEMPORARY SUTURE OF THE SKIN AND SUB-SKIN FABRIC
US5035692A (en) 1990-02-13 1991-07-30 Nicholas Herbert Hemostasis clip applicator
US5032127A (en) 1990-03-07 1991-07-16 Frazee John G Hemostatic clip and applicator therefor
US5290289A (en) * 1990-05-22 1994-03-01 Sanders Albert E Nitinol spinal instrumentation and method for surgically treating scoliosis
US5035702A (en) 1990-06-18 1991-07-30 Taheri Syde A Method and apparatus for providing an anastomosis
US5269809A (en) 1990-07-02 1993-12-14 American Cyanamid Company Locking mechanism for use with a slotted suture anchor
US5127413A (en) * 1990-08-09 1992-07-07 Ebert Edward A Sinous suture
US5366462A (en) 1990-08-28 1994-11-22 Robert L. Kaster Method of side-to-end vascular anastomotic stapling
US5234447A (en) 1990-08-28 1993-08-10 Robert L. Kaster Side-to-end vascular anastomotic staple apparatus
CA2049103C (en) 1990-09-06 1996-10-01 Royce Lewis Implant assist apparatus
US5353804A (en) 1990-09-18 1994-10-11 Peb Biopsy Corporation Method and device for percutaneous exisional breast biopsy
US5129913A (en) 1990-10-04 1992-07-14 Norbert Ruppert Surgical punch apparatus
US5042707A (en) 1990-10-16 1991-08-27 Taheri Syde A Intravascular stapler, and method of operating same
US5108422A (en) 1990-10-22 1992-04-28 United States Surgical Corporation Skin fastener
FR2668361A1 (en) 1990-10-30 1992-04-30 Mai Christian OSTEOSYNTHESIS CLIP AND PLATE WITH SELF-RETENTIVE DYNAMIC COMPRESSION.
CA2055985A1 (en) * 1990-12-20 1992-06-21 Daniel Shichman Fascia clip
US5221259A (en) 1990-12-27 1993-06-22 Novoste Corporation Wound treating device and method of using same
CS277367B6 (en) * 1990-12-29 1993-01-13 Krajicek Milan Three-layered vascular prosthesis
US5259846A (en) 1991-01-07 1993-11-09 United States Surgical Corporation Loop threaded combined surgical needle-suture device
US5064431A (en) 1991-01-16 1991-11-12 St. Jude Medical Incorporated Annuloplasty ring
US5100421A (en) 1991-02-05 1992-03-31 Cyprus Endosurgical Tools, Inc. Christoudias curved needle suture assembly
US5171252A (en) * 1991-02-05 1992-12-15 Friedland Thomas W Surgical fastening clip formed of a shape memory alloy, a method of making such a clip and a method of using such a clip
US5269783A (en) 1991-05-13 1993-12-14 United States Surgical Corporation Device and method for repairing torn tissue
US5217027A (en) * 1991-05-30 1993-06-08 Medtronic, Inc. Temporary cardiac lead
GB9111972D0 (en) 1991-06-04 1991-07-24 Clinical Product Dev Ltd Medical/surgical devices
US5452733A (en) 1993-02-22 1995-09-26 Stanford Surgical Technologies, Inc. Methods for performing thoracoscopic coronary artery bypass
US5370685A (en) 1991-07-16 1994-12-06 Stanford Surgical Technologies, Inc. Endovascular aortic valve replacement
US5735290A (en) 1993-02-22 1998-04-07 Heartport, Inc. Methods and systems for performing thoracoscopic coronary bypass and other procedures
US5236435A (en) 1991-07-22 1993-08-17 Sewell Jr Frank Laparoscopic surgical staple system
US5219358A (en) 1991-08-29 1993-06-15 Ethicon, Inc. Shape memory effect surgical needles
DE4133800C1 (en) 1991-10-12 1993-01-21 Ethicon Gmbh & Co Kg, 2000 Norderstedt, De
US5289963A (en) 1991-10-18 1994-03-01 United States Surgical Corporation Apparatus and method for applying surgical staples to attach an object to body tissue
US5152769A (en) 1991-11-04 1992-10-06 Will Baber Apparatus for laparoscopic suturing with improved suture needle
US5242456A (en) 1991-11-21 1993-09-07 Kensey Nash Corporation Apparatus and methods for clamping tissue and reflecting the same
IL100721A (en) 1992-01-21 1996-12-05 Milo Simcha Punch for opening passages between two compartments
JP3393383B2 (en) 1992-01-21 2003-04-07 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ Septal defect closure device
US5201880A (en) 1992-01-27 1993-04-13 Pioneering Technologies, Inc. Mitral and tricuspid annuloplasty rings
US5306296A (en) 1992-08-21 1994-04-26 Medtronic, Inc. Annuloplasty and suture rings
US5628757A (en) * 1992-02-04 1997-05-13 Hasson; Harrith M. Surgical instrument for holding a needle
US5261917A (en) 1992-02-19 1993-11-16 Hasson Harrith M Suture tying forceps with a plurality of suture holders and method of tying a suture
US5174087A (en) 1992-02-19 1992-12-29 Mitek Surgical Products, Inc. Suture anchor assembly packaging system
US5178629A (en) 1992-03-03 1993-01-12 Ethicon, Inc. Method of forming a suture knot
DE4303374A1 (en) * 1992-03-12 1993-09-23 Wolf Gmbh Richard
US5417700A (en) 1992-03-30 1995-05-23 Thomas D. Egan Automatic suturing and ligating device
US5236440A (en) 1992-04-14 1993-08-17 American Cyanamid Company Surgical fastener
US5355897A (en) 1992-04-16 1994-10-18 Ethicon, Inc. Method of performing a pyloroplasty/pylorectomy using a stapler having a shield
US5242457A (en) 1992-05-08 1993-09-07 Ethicon, Inc. Surgical instrument and staples for applying purse string sutures
US5484451A (en) 1992-05-08 1996-01-16 Ethicon, Inc. Endoscopic surgical instrument and staples for applying purse string sutures
DE4215449C1 (en) 1992-05-11 1993-09-02 Ethicon Gmbh & Co Kg, 2000 Norderstedt, De
DE4217202C2 (en) * 1992-05-23 1994-06-23 Kernforschungsz Karlsruhe Surgical sewing instrument
US5250053A (en) 1992-05-29 1993-10-05 Linvatec Corporation Suture shuttle device
US5207694A (en) 1992-06-18 1993-05-04 Surgical Invent Ab Method for performing a surgical occlusion, and kit and applicator for carrying out the method
US5653718A (en) 1994-05-16 1997-08-05 Yoon; Inbae Cannula anchoring system
EP0673230A1 (en) 1992-10-05 1995-09-27 Albert E. Sanders Nitinol instrumentation and method for treating scoliosis
US5334196A (en) 1992-10-05 1994-08-02 United States Surgical Corporation Endoscopic fastener remover
US5725538A (en) 1992-10-09 1998-03-10 United States Surgical Corporation Surgical clip applier
CA2133687C (en) 1992-10-09 2007-03-27 David T. Green Surgical clip applier
US5409498A (en) 1992-11-05 1995-04-25 Ethicon, Inc. Rotatable articulating endoscopic fastening instrument
US5304117A (en) 1992-11-27 1994-04-19 Wilk Peter J Closure method for use in laparoscopic surgery
US6036699A (en) 1992-12-10 2000-03-14 Perclose, Inc. Device and method for suturing tissue
US5403346A (en) 1992-12-31 1995-04-04 Loeser; Edward A. Self-affixing suture assembly
US5632753A (en) 1992-12-31 1997-05-27 Loeser; Edward A. Surgical procedures
US5336239A (en) 1993-01-15 1994-08-09 Gimpelson Richard J Surgical needle
US5366461A (en) 1993-01-25 1994-11-22 William Blasnik Sternum banding assembly
US5356424A (en) 1993-02-05 1994-10-18 American Cyanamid Co. Laparoscopic suturing device
US5304204A (en) 1993-02-09 1994-04-19 Ethicon, Inc. Receiverless surgical fasteners
US5522884A (en) 1993-02-19 1996-06-04 Medtronic, Inc. Holder for adjustable mitral & tricuspid annuloplasty rings
US5799661A (en) 1993-02-22 1998-09-01 Heartport, Inc. Devices and methods for port-access multivessel coronary artery bypass surgery
US5569274A (en) 1993-02-22 1996-10-29 Heartport, Inc. Endoscopic vascular clamping system and method
EP0688184A4 (en) 1993-03-11 1997-05-07 Greatbatch W Ltd Laparoscopic surgical grasper
US5312436A (en) 1993-03-11 1994-05-17 Coffey William R Suture for use in endoscopic surgery
US5403331A (en) 1993-03-12 1995-04-04 United States Surgical Corporation Looped suture ligating device containing a heat-shrinkable element
DE4310555C1 (en) * 1993-03-31 1993-12-09 Strobel & Soehne Gmbh & Co J Surgical machine stitching tissue edges together - has forceps opening and shutting in synchronism with needle to hold edges together before puncturing
US5346459A (en) 1993-04-14 1994-09-13 Minnesota Mining And Manufacturing Company Trocar
US5500000A (en) 1993-07-01 1996-03-19 United States Surgical Corporation Soft tissue repair system and method
JP3180219B2 (en) 1993-07-09 2001-06-25 ニプロ株式会社 Trocar
US5462561A (en) 1993-08-05 1995-10-31 Voda; Jan K. Suture device
US5858018A (en) 1993-08-25 1999-01-12 Apollo Camera, Llc Low profile tool for applying spring action ligation clips
US5450860A (en) 1993-08-31 1995-09-19 W. L. Gore & Associates, Inc. Device for tissue repair and method for employing same
FR2710254B1 (en) 1993-09-21 1995-10-27 Mai Christian Multi-branch osteosynthesis clip with self-retaining dynamic compression.
CA2132917C (en) 1993-10-07 2004-12-14 John Charles Robertson Circular anastomosis device
US5725554A (en) 1993-10-08 1998-03-10 Richard-Allan Medical Industries, Inc. Surgical staple and stapler
US5569301A (en) 1993-10-08 1996-10-29 United States Surgical Corporation Surgical incision members for endoscopic suturing apparatus
US5632752A (en) 1993-10-12 1997-05-27 Urohealth Systems, Inc. Surgical suturing device
WO1995011630A1 (en) 1993-10-25 1995-05-04 Children's Medical Center Corporation Retractable suture needle with self-contained driver
US5503635A (en) 1993-11-12 1996-04-02 United States Surgical Corporation Apparatus and method for performing compressional anastomoses
DE4340821C1 (en) 1993-12-01 1995-03-23 Univ Ludwigs Albert Surgical instrument for clamping a vessel or the like
WO1995016407A1 (en) 1993-12-13 1995-06-22 Brigham And Women's Hospital Aortic valve supporting device
US5527342A (en) * 1993-12-14 1996-06-18 Pietrzak; William S. Method and apparatus for securing soft tissues, tendons and ligaments to bone
US5376096A (en) 1993-12-17 1994-12-27 Vance Products Inc. Medical instrument for driving a suture needle
DK145593A (en) 1993-12-23 1995-06-24 Joergen A Rygaard Surgical double instrument for performing connection mlm. arteries (end-to-side anastomosis)
WO1995018572A1 (en) 1994-01-04 1995-07-13 Alpha Surgical Technologies, Inc. Stapling device
US5437681A (en) 1994-01-13 1995-08-01 Suturtek Inc. Suturing instrument with thread management
US5423821A (en) 1994-01-18 1995-06-13 Pasque; Michael K. Sternal closure device
DE4402058C1 (en) 1994-01-25 1995-04-13 Andreas Dr Med Asch Implantable temporary electrode cable
US5538509A (en) 1994-01-31 1996-07-23 Richard-Allan Medical Industries, Inc. Trocar assembly
US5456246A (en) 1994-02-23 1995-10-10 Arthrex, Inc. Fat pad retractor
US5431666A (en) 1994-02-24 1995-07-11 Lasersurge, Inc. Surgical suture instrument
US5451231A (en) 1994-03-11 1995-09-19 Ryder International Corporation Surgical staple remover
CA2192819A1 (en) 1994-06-17 1995-12-28 Christopher Francis Heck Surgical stapling instrument and method thereof
US5732872A (en) 1994-06-17 1998-03-31 Heartport, Inc. Surgical stapling instrument
US5569205A (en) 1994-07-14 1996-10-29 Hart; Charles C. Multiport trocar
US5582616A (en) 1994-08-05 1996-12-10 Origin Medsystems, Inc. Surgical helical fastener with applicator
US5562685A (en) 1994-09-16 1996-10-08 General Surgical Innovations, Inc. Surgical instrument for placing suture or fasteners
US5618311A (en) 1994-09-28 1997-04-08 Gryskiewicz; Joseph M. Surgical subcuticular fastener system
US5571090A (en) 1994-10-07 1996-11-05 United States Surgical Corporation Vascular suturing apparatus
CA2157744C (en) 1994-10-07 2005-08-23 Charles R. Sherts Endoscopic vascular suturing apparatus
CA2162620A1 (en) 1994-11-11 1996-05-12 Gene Samson Microcatheter-less coil delivery device
US5643305A (en) 1994-11-18 1997-07-01 Al-Tameem; Moshin Device for excision of a fistula
US5665109A (en) * 1994-12-29 1997-09-09 Yoon; Inbae Methods and apparatus for suturing tissue
US5643295A (en) 1994-12-29 1997-07-01 Yoon; Inbae Methods and apparatus for suturing tissue
US5653716A (en) 1994-12-29 1997-08-05 Acufex Microsurgical, Inc. Suture manipulating instrument with grasping members
US5797933A (en) 1996-07-16 1998-08-25 Heartport, Inc. Coronary shunt and method of use
US5695504A (en) 1995-02-24 1997-12-09 Heartport, Inc. Devices and methods for performing a vascular anastomosis
US5976159A (en) 1995-02-24 1999-11-02 Heartport, Inc. Surgical clips and methods for tissue approximation
US5795308A (en) 1995-03-09 1998-08-18 Russin; Lincoln D. Apparatus for coaxial breast biopsy
US5695505A (en) 1995-03-09 1997-12-09 Yoon; Inbae Multifunctional spring clips and cartridges and applicators therefor
DE19509115C2 (en) 1995-03-16 1997-11-27 Deutsche Forsch Luft Raumfahrt Surgical device for preparing an anastomosis using minimally invasive surgical techniques
DE69624525T2 (en) 1995-03-30 2003-03-20 Boston Scient Ltd System for implanting liquid spirals with a secondary structure
US5609608A (en) 1995-10-27 1997-03-11 Regents Of The University Of California Miniature plastic gripper and fabrication method
US5630540A (en) 1995-05-24 1997-05-20 United States Surgical Corporation Surgical staple and staple drive member
US5571175A (en) 1995-06-07 1996-11-05 St. Jude Medical, Inc. Suture guard for prosthetic heart valve
US5660186A (en) 1995-06-07 1997-08-26 Marshfield Clinic Spiral biopsy stylet
US6132438A (en) * 1995-06-07 2000-10-17 Ep Technologies, Inc. Devices for installing stasis reducing means in body tissue
US5989242A (en) 1995-06-26 1999-11-23 Trimedyne, Inc. Therapeutic appliance releasing device
KR0153285B1 (en) * 1995-06-29 1998-12-01 이대원 Aps camera with possibility of imformation input
US5582619A (en) 1995-06-30 1996-12-10 Target Therapeutics, Inc. Stretch resistant vaso-occlusive coils
US5533236A (en) 1995-08-08 1996-07-09 Chun-Hsiung Hsu Paper holder
US6032849A (en) 1995-08-28 2000-03-07 United States Surgical Surgical stapler
CA2184958A1 (en) 1995-09-22 1997-03-23 John S. Gentelia Improved trocar-cannulla device
US5702412A (en) 1995-10-03 1997-12-30 Cedars-Sinai Medical Center Method and devices for performing vascular anastomosis
US5690662A (en) 1995-10-12 1997-11-25 The Trustees Of Columbia University In The City Of New York Device and method to create a smooth opening on a tubular structure such as an artery or a vein
EP0955933B1 (en) 1995-10-13 2009-08-26 Medtronic Vascular, Inc. A device for interstitial transvascular intervention
US5700271A (en) 1995-10-20 1997-12-23 United States Surgical Corporation Apparatus for applying surgical clips
US5700270A (en) 1995-10-20 1997-12-23 United States Surgical Corporation Surgical clip applier
US5941442A (en) 1995-10-27 1999-08-24 United States Surgical Surgical stapler
ATE188862T1 (en) 1995-10-31 2000-02-15 Oticon As ANASTOMOTIC INSTRUMENT FOR USE IN A TERMINOLATERAL ANASTOMOSIS
BE1009746A3 (en) 1995-11-07 1997-07-01 Dereume Jean Pierre Georges Em Capture device introduced in a cavity of a human or animal body.
US5645568A (en) 1995-11-20 1997-07-08 Medicinelodge, Inc. Expandable body suture
US5658308A (en) 1995-12-04 1997-08-19 Target Therapeutics, Inc. Bioactive occlusion coil
DE19547617C1 (en) 1995-12-20 1997-09-18 Malte Neus Appliance for inserting and replacing surgical implant
US5810853A (en) 1996-01-16 1998-09-22 Yoon; Inbae Knotting element for use in suturing anatomical tissue and methods therefor
RU2110222C1 (en) 1996-01-18 1998-05-10 Устинова Елена Юрьевна Device for forming of intestinal end-to-end anastomosis
US5827265A (en) 1996-02-07 1998-10-27 Regents Of The University Of California Intraluminal tissue welding for anastomosis
US5728135A (en) 1996-02-09 1998-03-17 Ethicon, Inc. Stiffened suture for use in a suturing device
US5769870A (en) 1996-02-20 1998-06-23 Cardiothoracic Systems, Inc. Perfusion device for maintaining blood flow in a vessel while isolating an anastomosis
US6402780B2 (en) 1996-02-23 2002-06-11 Cardiovascular Technologies, L.L.C. Means and method of replacing a heart valve in a minimally invasive manner
US5972004A (en) 1996-02-23 1999-10-26 Cardiovascular Technologies, Llc. Wire fasteners for use in minimally invasive surgery and apparatus and methods for handling those fasteners
US6162233A (en) 1996-02-23 2000-12-19 Cardiovascular Technologies, Llc Wire fasteners for use in minimally invasive surgery and means and methods for handling those fasteners
US5891160A (en) 1996-02-23 1999-04-06 Cardiovascular Technologies, Llc Fastener delivery and deployment mechanism and method for placing the fastener in minimally invasive surgery
US20020068949A1 (en) 1996-02-23 2002-06-06 Williamson Warren P. Extremely long wire fasteners for use in minimally invasive surgery and means and method for handling those fasteners
JP3209430B2 (en) 1996-02-29 2001-09-17 オチコン アクツイエセルスカプ Anastomotic device for use when performing end-to-end anastomosis
JP3776529B2 (en) 1996-02-29 2006-05-17 オリンパス株式会社 Clip device
US5782844A (en) 1996-03-05 1998-07-21 Inbae Yoon Suture spring device applicator
US5810851A (en) 1996-03-05 1998-09-22 Yoon; Inbae Suture spring device
EP0904019B1 (en) 1996-04-30 2002-05-22 Oticon A/S Anastomotic instrument for use when performing an end-to-side anastomosis
US5746753A (en) 1996-05-13 1998-05-05 Boston Scientific Corporation Needle grasping apparatus
US5800421A (en) 1996-06-12 1998-09-01 Lemelson; Jerome H. Medical devices using electrosensitive gels
US5893856A (en) 1996-06-12 1999-04-13 Mitek Surgical Products, Inc. Apparatus and method for binding a first layer of material to a second layer of material
US6007544A (en) 1996-06-14 1999-12-28 Beth Israel Deaconess Medical Center Catheter apparatus having an improved shape-memory alloy cuff and inflatable on-demand balloon for creating a bypass graft in-vivo
US5676670A (en) 1996-06-14 1997-10-14 Beth Israel Deaconess Medical Center Catheter apparatus and method for creating a vascular bypass in-vivo
US5797920A (en) 1996-06-14 1998-08-25 Beth Israel Deaconess Medical Center Catheter apparatus and method using a shape-memory alloy cuff for creating a bypass graft in-vivo
JP3304346B2 (en) 1996-06-20 2002-07-22 ニプロ株式会社 Suture for endocardial suture surgery
US5833698A (en) 1996-07-23 1998-11-10 United States Surgical Corporation Anastomosis instrument and method
US5820631A (en) 1996-08-01 1998-10-13 Nr Medical, Inc. Device and method for suturing tissue adjacent to a blood vessel
FR2751867B1 (en) 1996-08-05 1999-05-21 Leriche Rene Ass PROSTHESIS COLLERETTE
US5697913A (en) 1996-08-09 1997-12-16 Ethicon Endo-Surgery, Inc. Trocar including cannula with stepped region
US5683417A (en) 1996-08-14 1997-11-04 Cooper; William I. Suture and method for endoscopic surgery
US5810848A (en) 1996-08-21 1998-09-22 Hayhurst; John O. Suturing system
FR2752720A1 (en) 1996-09-03 1998-03-06 Medinov Amp SURGICAL STAPLE SUPPORT OF THE ELASTIC, SUPERELASTIC OR SHAPE MEMORY TYPE
US5976164A (en) 1996-09-13 1999-11-02 Eclipse Surgical Technologies, Inc. Method and apparatus for myocardial revascularization and/or biopsy of the heart
US5871495A (en) 1996-09-13 1999-02-16 Eclipse Surgical Technologies, Inc. Method and apparatus for mechanical transmyocardial revascularization of the heart
US5830221A (en) 1996-09-20 1998-11-03 United States Surgical Corporation Coil fastener applier
DE29616632U1 (en) 1996-09-24 1996-11-28 Aesculap Ag Surgical application device for U-shaped clips
US6036710A (en) 1996-10-04 2000-03-14 United States Surgical Apparatus for formation of a hole in a blood vessel
US5941434A (en) 1996-10-11 1999-08-24 Green; Mark R. Multi-strap holder
US5755778A (en) 1996-10-16 1998-05-26 Nitinol Medical Technologies, Inc. Anastomosis device
US5941908A (en) 1997-04-23 1999-08-24 Vascular Science, Inc. Artificial medical graft with a releasable retainer
US5976178A (en) 1996-11-07 1999-11-02 Vascular Science Inc. Medical grafting methods
AU721415B2 (en) 1996-11-08 2000-07-06 Converge Medical, Inc. Percutaneous bypass graft and securing system
US5993467A (en) 1996-11-27 1999-11-30 Yoon; Inbae Suturing instrument with rotatably mounted spreadable needle holder
CA2224366C (en) 1996-12-11 2006-10-31 Ethicon, Inc. Meniscal repair device
US5911352A (en) 1996-12-17 1999-06-15 United States Surgical Corporation Surgical stapling apparatus
US5972024A (en) * 1996-12-24 1999-10-26 Metacardia, Inc. Suture-staple apparatus and method
US6074401A (en) 1997-01-09 2000-06-13 Coalescent Surgical, Inc. Pinned retainer surgical fasteners, instruments and methods for minimally invasive vascular and endoscopic surgery
US6149658A (en) 1997-01-09 2000-11-21 Coalescent Surgical, Inc. Sutured staple surgical fasteners, instruments and methods for minimally invasive vascular and endoscopic surgery
US5879371A (en) 1997-01-09 1999-03-09 Elective Vascular Interventions, Inc. Ferruled loop surgical fasteners, instruments, and methods for minimally invasive vascular and endoscopic surgery
US5961539A (en) 1997-01-17 1999-10-05 Segmed, Inc. Method and apparatus for sizing, stabilizing and/or reducing the circumference of an anatomical structure
US5957938A (en) 1997-02-05 1999-09-28 United States Surgical Corporation Tissue everting needle
US5893369A (en) 1997-02-24 1999-04-13 Lemole; Gerald M. Procedure for bypassing an occlusion in a blood vessel
DE19711288B4 (en) 1997-03-18 2004-11-04 Helmut Dipl.-Ing. Wurster Applicator to hold and close a surgical clip
US6409739B1 (en) 1997-05-19 2002-06-25 Cardio Medical Solutions, Inc. Device and method for assisting end-to side anastomosis
US5944730A (en) 1997-05-19 1999-08-31 Cardio Medical Solutions, Inc. Device and method for assisting end-to-side anastomosis
US5908428A (en) 1997-05-27 1999-06-01 United States Surgical Corporation Stitching devices for heart valve replacement surgery
US5827316A (en) 1997-06-05 1998-10-27 Atrion Medical Products, Inc. Rotating aortic punch
WO1999000059A1 (en) 1997-06-27 1999-01-07 The Trustees Of Columbia University In The City Of New York Method and apparatus for circulatory valve repair
US6071292A (en) 1997-06-28 2000-06-06 Transvascular, Inc. Transluminal methods and devices for closing, forming attachments to, and/or forming anastomotic junctions in, luminal anatomical structures
US5957940A (en) 1997-06-30 1999-09-28 Eva Corporation Fasteners for use in the surgical repair of aneurysms
US5997556A (en) 1997-06-30 1999-12-07 Eva Corporation Surgical fastener
DE19732234A1 (en) 1997-07-26 1999-01-28 Georg Dr Med Quatchadze Surgical endoscopic instrument
US6063070A (en) 1997-08-05 2000-05-16 Target Therapeutics, Inc. Detachable aneurysm neck bridge (II)
US5954732A (en) 1997-09-10 1999-09-21 Hart; Charles C. Suturing apparatus and method
US5964782A (en) 1997-09-18 1999-10-12 Scimed Life Systems, Inc. Closure device and method
US5984959A (en) 1997-09-19 1999-11-16 United States Surgical Heart valve replacement tools and procedures
US5893865A (en) 1997-09-23 1999-04-13 Baxter Research Medical, Inc. Apparatus and method for improved aortic incision
US6074416A (en) 1997-10-09 2000-06-13 St. Jude Medical Cardiovascular Group, Inc. Wire connector structures for tubular grafts
NL1007349C2 (en) 1997-10-24 1999-04-27 Suyker Wilhelmus Joseph Leonardus System for the mechanical production of anastomoses between hollow structures; as well as device and applicator for use therewith.
US5989268A (en) 1997-10-28 1999-11-23 Boston Scientific Corporation Endoscopic hemostatic clipping device
US6139540A (en) 1997-10-30 2000-10-31 Lake Region Manufacturing, Inc. Guidewire with disposition to coil
US6241691B1 (en) 1997-12-05 2001-06-05 Micrus Corporation Coated superelastic stent
US6159165A (en) 1997-12-05 2000-12-12 Micrus Corporation Three dimensional spherical micro-coils manufactured from radiopaque nickel-titanium microstrand
US6332893B1 (en) 1997-12-17 2001-12-25 Myocor, Inc. Valve to myocardium tension members device and method
US5976161A (en) 1998-01-07 1999-11-02 University Of New Mexico Tissue everting apparatus and method
US5919199A (en) 1998-01-14 1999-07-06 Mers Kelly; William Charles Suture device
IT1304761B1 (en) 1998-01-20 2001-03-29 Nardino Righi DISPOSABLE SAFETY SYRINGE.
US6416527B1 (en) 1998-01-28 2002-07-09 St. Jude Medical Cardiovascular Group, Inc. Vessel cutting device
ATE320229T1 (en) 1998-01-30 2006-04-15 St Jude Medical Atg Inc MEDICAL TRANSPLANT CONNECTOR OR PLUG AND METHOD FOR PRODUCING THE SAME
US6036703A (en) 1998-02-06 2000-03-14 Ethicon Endo-Surgery Inc. Method and apparatus for establishing anastomotic passageways
US6651670B2 (en) 1998-02-13 2003-11-25 Ventrica, Inc. Delivering a conduit into a heart wall to place a coronary vessel in communication with a heart chamber and removing tissue from the vessel or heart wall to facilitate such communication
US6352543B1 (en) 2000-04-29 2002-03-05 Ventrica, Inc. Methods for forming anastomoses using magnetic force
US6280460B1 (en) 1998-02-13 2001-08-28 Heartport, Inc. Devices and methods for performing vascular anastomosis
US5941888A (en) 1998-02-18 1999-08-24 Target Therapeutics, Inc. Vaso-occlusive member assembly with multiple detaching points
US5951576A (en) 1998-03-02 1999-09-14 Wakabayashi; Akio End-to-side vascular anastomosing stapling device
US6241741B1 (en) 1998-03-09 2001-06-05 Corvascular Surgical Systems, Inc. Anastomosis device and method
US6110188A (en) 1998-03-09 2000-08-29 Corvascular, Inc. Anastomosis method
NO981277D0 (en) 1998-03-20 1998-03-20 Erik Fosse Method and apparatus for suture-free anastomosis
US6056751A (en) 1998-04-16 2000-05-02 Axya Medical, Inc. Sutureless soft tissue fixation assembly
US6074418A (en) 1998-04-20 2000-06-13 St. Jude Medical, Inc. Driver tool for heart valve prosthesis fasteners
US6033419A (en) 1998-05-15 2000-03-07 Sulzer Carbomedics Inc. Apparatus and method for cutting a heart valve annulus
US6113611A (en) 1998-05-28 2000-09-05 Advanced Vascular Technologies, Llc Surgical fastener and delivery system
US6979338B1 (en) 1998-05-29 2005-12-27 By-Pass Inc. Low profile anastomosis connector
JP2002516696A (en) 1998-05-29 2002-06-11 バイ−パス・インク. Methods and devices for vascular surgery
US7063711B1 (en) 1998-05-29 2006-06-20 By-Pass, Inc. Vascular surgery
US5919207A (en) 1998-06-02 1999-07-06 Taheri; Syde A. Percutaneous arterial closure with staples
EP1083832B1 (en) 1998-06-03 2009-01-14 Medtronic, Inc. Tissue connector apparatus
US6641593B1 (en) 1998-06-03 2003-11-04 Coalescent Surgical, Inc. Tissue connector apparatus and methods
CA2334000C (en) 1998-06-03 2010-01-26 Coalescent Surgical, Inc. Tissue connector apparatus and methods
WO2000015144A1 (en) 1998-06-10 2000-03-23 Advanced Bypass Technologies, Inc. Aortic aneurysm treatment systems
US6250308B1 (en) 1998-06-16 2001-06-26 Cardiac Concepts, Inc. Mitral valve annuloplasty ring and method of implanting
US6537248B2 (en) 1998-07-07 2003-03-25 Medtronic, Inc. Helical needle apparatus for creating a virtual electrode used for the ablation of tissue
US6165183A (en) 1998-07-15 2000-12-26 St. Jude Medical, Inc. Mitral and tricuspid valve repair
US6418597B1 (en) 1998-07-15 2002-07-16 Avery Dennison Corporation Plastic fastener, fastener clip, fastener dispensing tool and method of fastening objects
US6461320B1 (en) 1998-08-12 2002-10-08 Cardica, Inc. Method and system for attaching a graft to a blood vessel
US6206913B1 (en) 1998-08-12 2001-03-27 Vascular Innovations, Inc. Method and system for attaching a graft to a blood vessel
US6143004A (en) 1998-08-18 2000-11-07 Atrion Medical Products, Inc. Suturing device
US6296622B1 (en) 1998-12-21 2001-10-02 Micrus Corporation Endoluminal device delivery system using axially recovering shape memory material
US6083237A (en) 1998-10-23 2000-07-04 Ethico Endo-Surgery, Inc. Biopsy instrument with tissue penetrating spiral
US6152937A (en) 1998-11-06 2000-11-28 St. Jude Medical Cardiovascular Group, Inc. Medical graft connector and methods of making and installing same
US6475222B1 (en) 1998-11-06 2002-11-05 St. Jude Medical Atg, Inc. Minimally invasive revascularization apparatus and methods
US6113612A (en) 1998-11-06 2000-09-05 St. Jude Medical Cardiovascular Group, Inc. Medical anastomosis apparatus
US6221083B1 (en) * 1998-11-16 2001-04-24 Paul W. Mayer Synchronized stapler/needle driver/forceps for motion in all planes
GB9827415D0 (en) 1998-12-11 1999-02-03 Wild Andrew M Surgical apparatus and method for occluding a body passageway
US6120524A (en) 1999-02-16 2000-09-19 Taheri; Syde A. Device for closing an arterial puncture and method
US8118822B2 (en) 1999-03-01 2012-02-21 Medtronic, Inc. Bridge clip tissue connector apparatus and methods
US6406492B1 (en) 1999-04-08 2002-06-18 Sulzer Carbomedics Inc. Annuloplasty ring holder
US6248117B1 (en) 1999-04-16 2001-06-19 Vital Access Corp Anastomosis apparatus for use in intraluminally directed vascular anastomosis
US6623494B1 (en) 1999-04-16 2003-09-23 Integrated Vascular Interventional Technologies, L.C. (Ivit, Lc) Methods and systems for intraluminally directed vascular anastomosis
US6743244B2 (en) 1999-04-16 2004-06-01 Integrated Vascular Interventional Technologies, L.C. Soft anvil apparatus for cutting anastomosis fenestra
JP2002541974A (en) 1999-04-28 2002-12-10 セント・ジュード・メディカル・インコーポレーテッド Heart substitute valve
US6428550B1 (en) 1999-05-18 2002-08-06 Cardica, Inc. Sutureless closure and deployment system for connecting blood vessels
WO2000069364A2 (en) 1999-05-18 2000-11-23 Vascular Innovations, Inc. Implantable medical device such as an anastomosis device
US6217611B1 (en) 1999-05-26 2001-04-17 Sulzer Carbomedics Inc. Modular heart valve prothesis
US6699256B1 (en) 1999-06-04 2004-03-02 St. Jude Medical Atg, Inc. Medical grafting apparatus and methods
US7192442B2 (en) 1999-06-30 2007-03-20 Edwards Lifesciences Ag Method and device for treatment of mitral insufficiency
US6391038B2 (en) 1999-07-28 2002-05-21 Cardica, Inc. Anastomosis system and method for controlling a tissue site
US6165185A (en) 1999-07-28 2000-12-26 Vasconnect, Inc. Method for interconnecting vessels in a patient
US6197037B1 (en) 1999-07-29 2001-03-06 John Hunter Hair Surgical fastener for joining adjacent bone portions
US6635214B2 (en) 1999-09-10 2003-10-21 Ventrica, Inc. Manufacturing conduits for use in placing a target vessel in fluid communication with a source of blood
CA2381818C (en) 1999-09-13 2009-08-04 Rex Medical, L.P. Vascular closure
US6358258B1 (en) 1999-09-14 2002-03-19 Abbott Laboratories Device and method for performing end-to-side anastomosis
FR2799364B1 (en) 1999-10-12 2001-11-23 Jacques Seguin MINIMALLY INVASIVE CANCELING DEVICE
US6312447B1 (en) 1999-10-13 2001-11-06 The General Hospital Corporation Devices and methods for percutaneous mitral valve repair
US6626930B1 (en) 1999-10-21 2003-09-30 Edwards Lifesciences Corporation Minimally invasive mitral valve repair method and apparatus
US6926730B1 (en) 2000-10-10 2005-08-09 Medtronic, Inc. Minimally invasive valve repair procedure and apparatus
US6402764B1 (en) 1999-11-15 2002-06-11 Cardica, Inc. Everter and threadthrough system for attaching graft vessel to anastomosis device
US6428555B1 (en) 2000-01-28 2002-08-06 J. Kenneth Koster, Jr. Anastomosis punch device and method
US6797002B2 (en) 2000-02-02 2004-09-28 Paul A. Spence Heart valve repair apparatus and methods
US6551332B1 (en) 2000-03-31 2003-04-22 Coalescent Surgical, Inc. Multiple bias surgical fastener
US6802847B1 (en) 2000-04-29 2004-10-12 Ventrica, Inc. Devices and methods for forming magnetic anastomoses and ports in vessels
US6368348B1 (en) 2000-05-15 2002-04-09 Shlomo Gabbay Annuloplasty prosthesis for supporting an annulus of a heart valve
US6869444B2 (en) 2000-05-22 2005-03-22 Shlomo Gabbay Low invasive implantable cardiac prosthesis and method for helping improve operation of a heart valve
US6419695B1 (en) 2000-05-22 2002-07-16 Shlomo Gabbay Cardiac prosthesis for helping improve operation of a heart valve
US6406493B1 (en) 2000-06-02 2002-06-18 Hosheng Tu Expandable annuloplasty ring and methods of use
US6702826B2 (en) 2000-06-23 2004-03-09 Viacor, Inc. Automated annular plication for mitral valve repair
US6409758B2 (en) 2000-07-27 2002-06-25 Edwards Lifesciences Corporation Heart valve holder for constricting the valve commissures and methods of use
SE0002878D0 (en) 2000-08-11 2000-08-11 Kimblad Ola Device and method of treatment of atrioventricular regurgitation
WO2002017796A1 (en) 2000-09-01 2002-03-07 Advanced Vascular Technologies, Llc Vascular bypass grafting instrument and method
US20040093024A1 (en) 2000-09-01 2004-05-13 James Lousararian Advanced wound site management systems and methods
US6918917B1 (en) 2000-10-10 2005-07-19 Medtronic, Inc. Minimally invasive annuloplasty procedure and apparatus
US6776785B1 (en) 2000-10-12 2004-08-17 Cardica, Inc. Implantable superelastic anastomosis device
US6425900B1 (en) 2000-10-19 2002-07-30 Ethicon Endo-Surgery Method for attaching hernia mesh
US7070618B2 (en) 2000-10-25 2006-07-04 Viacor, Inc. Mitral shield
EP1210912A3 (en) 2000-11-27 2003-12-17 Terumo Kabushiki Kaisha Instrument for extroverting blood vessel
US6537286B2 (en) 2001-01-19 2003-03-25 Sergio Acampora Device for fastening a cranial flap to the cranial vault
JP4097924B2 (en) 2001-02-05 2008-06-11 オリンパス株式会社 Biological tissue clip device
US6619291B2 (en) 2001-04-24 2003-09-16 Edwin J. Hlavka Method and apparatus for catheter-based annuloplasty
US20020173803A1 (en) 2001-05-01 2002-11-21 Stephen Ainsworth Self-closing surgical clip for tissue
US20060293701A1 (en) 2001-05-02 2006-12-28 Medtronic, Inc. Self-closing surgical clip for tissue
US6562053B2 (en) 2001-05-21 2003-05-13 Ethicon, Inc. Curved mandrel for assisting vessel eversion
US6776782B2 (en) 2001-06-26 2004-08-17 Ethicon, Inc. Vessel eversion instrument with wiping element
US6547799B2 (en) 2001-06-26 2003-04-15 Ethicon, Inc. Vessel eversion instrument with pressurizable membrane
US6589255B2 (en) 2001-06-28 2003-07-08 Ethicon, Inc. Vessel eversion instrument with filament elements
US6629988B2 (en) 2001-08-28 2003-10-07 Ethicon, Inc. Composite staple for completing an anastomosis
US7104949B2 (en) 2001-08-31 2006-09-12 Ams Research Corporation Surgical articles for placing an implant about a tubular tissue structure and methods
US6776784B2 (en) 2001-09-06 2004-08-17 Core Medical, Inc. Clip apparatus for closing septal defects and methods of use
US7097659B2 (en) 2001-09-07 2006-08-29 Medtronic, Inc. Fixation band for affixing a prosthetic heart valve to tissue
US6712829B2 (en) 2001-09-10 2004-03-30 Ethicon, Inc. Vessel eversion instrument with conical, expandable mandrel
US6575985B2 (en) 2001-09-10 2003-06-10 Ethicon, Inc. Vessel eversion instrument with conical holder
US20030120341A1 (en) 2001-12-21 2003-06-26 Hani Shennib Devices and methods of repairing cardiac valves
CA2471871A1 (en) 2002-01-14 2003-07-24 Nmt Medical, Inc. Patent foramen ovale (pfo) closure method and device
US6821286B1 (en) 2002-01-23 2004-11-23 Cardica, Inc. System for preparing a graft vessel for anastomosis
US6704401B2 (en) 2002-03-22 2004-03-09 Hewlett-Packard Development Company, L.P. System of and method for configuring an automatic appliance
US20030199974A1 (en) 2002-04-18 2003-10-23 Coalescent Surgical, Inc. Annuloplasty apparatus and methods
US7056330B2 (en) 2002-05-31 2006-06-06 Ethicon Endo-Surgery, Inc. Method for applying tissue fastener
US8066724B2 (en) 2002-09-12 2011-11-29 Medtronic, Inc. Anastomosis apparatus and methods
US8105345B2 (en) 2002-10-04 2012-01-31 Medtronic, Inc. Anastomosis apparatus and methods
AU2003290979A1 (en) 2002-11-15 2004-06-15 The Government Of The United States Of America As Represented By The Secretary Of Health And Human Services Method and device for catheter-based repair of cardiac valves
US7399310B2 (en) 2002-12-16 2008-07-15 Edrich Vascular Devices, Inc. Endovascular stapler
US8377082B2 (en) 2003-01-14 2013-02-19 Medtronic, Inc. Methods and apparatus for making precise incisions in body vessels
US20040193259A1 (en) 2003-03-25 2004-09-30 Shlomo Gabbay Sizing apparatus for cardiac prostheses and method of using same
US20050075659A1 (en) 2003-03-30 2005-04-07 Fidel Realyvasquez Apparatus and methods for minimally invasive valve surgery
US20060271081A1 (en) 2003-03-30 2006-11-30 Fidel Realyvasquez Apparatus and methods for valve repair
US20050107871A1 (en) 2003-03-30 2005-05-19 Fidel Realyvasquez Apparatus and methods for valve repair
US20040220593A1 (en) 2003-05-01 2004-11-04 Secant Medical, Llc Restraining clip for mitral valve repair
US8394114B2 (en) 2003-09-26 2013-03-12 Medtronic, Inc. Surgical connection apparatus and methods
US7556647B2 (en) 2003-10-08 2009-07-07 Arbor Surgical Technologies, Inc. Attachment device and methods of using the same
US7879047B2 (en) 2003-12-10 2011-02-01 Medtronic, Inc. Surgical connection apparatus and methods
EP2433591B1 (en) 2004-05-14 2016-04-27 St. Jude Medical, Inc. Apparatus for holding an annuloplasty ring
US20060122634A1 (en) 2004-12-03 2006-06-08 Ino Takashi H Apparatus and method for delivering fasteners during valve replacement
EP1959864B1 (en) 2005-12-07 2018-03-07 Medtronic, Inc. Connection systems for two piece prosthetic heart valve assemblies
JP4943796B2 (en) 2006-09-29 2012-05-30 テルモ株式会社 Medical device
US20090112233A1 (en) 2007-10-30 2009-04-30 Medtronic Vascular, Inc. Prosthesis Fixation Apparatus and Methods
US8177836B2 (en) 2008-03-10 2012-05-15 Medtronic, Inc. Apparatus and methods for minimally invasive valve repair

Patent Citations (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1087186A (en) * 1909-03-22 1914-02-17 Socrates Scholfield Illustrative educational device.
US1167014A (en) * 1915-06-25 1916-01-04 William R O'brien Veterinary surgical instrument.
US3082426A (en) * 1960-06-17 1963-03-26 George Oliver Halsted Surgical stapling device
US3570497A (en) * 1969-01-16 1971-03-16 Gerald M Lemole Suture apparatus and methods
US3638654A (en) * 1969-07-11 1972-02-01 Uche Akuba Suturing instrument
US4006747A (en) * 1975-04-23 1977-02-08 Ethicon, Inc. Surgical method
US4140125A (en) * 1976-02-25 1979-02-20 Med-Pro, Ltd. Surgical tape device
US4073179A (en) * 1976-06-01 1978-02-14 Codman & Shurtleff, Inc. Clip removing device
US4243048A (en) * 1976-09-21 1981-01-06 Jim Zegeer Biopsy device
US4192315A (en) * 1976-12-23 1980-03-11 Aesculap-Werke Aktiengesellschaft Vormals Jetter & Scheerer Clip for surgical purposes
US4185636A (en) * 1977-12-29 1980-01-29 Albert Einstein College Of Medicine Of Yeshiva University Suture organizer, prosthetic device holder, and related surgical procedures
US4366819A (en) * 1980-11-17 1983-01-04 Kaster Robert L Anastomotic fitting
US4809695A (en) * 1981-10-21 1989-03-07 Owen M. Gwathmey Suturing assembly and method
US4492229A (en) * 1982-09-03 1985-01-08 Grunwald Ronald P Suture guide holder
US5597378A (en) * 1983-10-14 1997-01-28 Raychem Corporation Medical devices incorporating SIM alloy elements
US4641652A (en) * 1984-04-12 1987-02-10 Richard Wolf Gmbh Applicator for tying sewing threads
US4653496A (en) * 1985-02-01 1987-03-31 Bundy Mark A Transluminal lysing system
US4576605A (en) * 1985-03-01 1986-03-18 Nauchno-Issledovatelsky Institut Khirurgii Imeni A.V. Vishnevskogo Cardiac valve prosthesis
US4637380A (en) * 1985-06-24 1987-01-20 Orejola Wilmo C Surgical wound closures
US4730615A (en) * 1986-03-03 1988-03-15 Pfizer Hospital Products Group, Inc. Sternum closure device
US4896668A (en) * 1986-04-10 1990-01-30 Peters Plate set for osteal fixation, equipped with suture strands
US4719924A (en) * 1986-09-09 1988-01-19 C. R. Bard, Inc. Small diameter steerable guidewire with adjustable tip
US4732151A (en) * 1986-10-08 1988-03-22 Patent Research & Development Corp. Low trauma suturing
US4719917A (en) * 1987-02-17 1988-01-19 Minnesota Mining And Manufacturing Company Surgical staple
US5480405A (en) * 1987-05-14 1996-01-02 Yoon; Inbae Anchor applier instrument for use in suturing tissue
US4890615A (en) * 1987-11-05 1990-01-02 Concept, Inc. Arthroscopic suturing instrument
US4890615B1 (en) * 1987-11-05 1993-11-16 Linvatec Corporation Arthroscopic suturing instrument
US5002562A (en) * 1988-06-03 1991-03-26 Oberlander Michael A Surgical clip
US4901721A (en) * 1988-08-02 1990-02-20 Hakki Samir I Suturing device
US4990152A (en) * 1988-10-12 1991-02-05 Inbae Yoon Applicator device housing multiple elastic ligatures in series and for dilating and applying elastic ligatures onto anatomical tissue
US4994069A (en) * 1988-11-02 1991-02-19 Target Therapeutics Vaso-occlusion coil and method
US4899744A (en) * 1988-12-15 1990-02-13 Tatsuo Fujitsuka Apparatus for anastomosing digestive tract
US4997439A (en) * 1989-01-26 1991-03-05 Chen Fusen H Surgical closure or anastomotic device
US4983176A (en) * 1989-03-06 1991-01-08 University Of New Mexico Deformable plastic surgical clip
US5178634A (en) * 1989-03-31 1993-01-12 Wilson Ramos Martinez Aortic valved tubes for human implants
US5002550A (en) * 1989-06-06 1991-03-26 Mitek Surgical Products, Inc. Suture anchor installation tool
US5601572A (en) * 1989-08-16 1997-02-11 Raychem Corporation Device or apparatus for manipulating matter having a elastic ring clip
US4991567A (en) * 1990-01-16 1991-02-12 Mccuen Ii Brooks W Micro-iris retractor
US5002563A (en) * 1990-02-22 1991-03-26 Raychem Corporation Sutures utilizing shape memory alloys
US5088692A (en) * 1990-09-04 1992-02-18 Weiler Raywood C Heavy duty staple remover
US5868702A (en) * 1991-07-16 1999-02-09 Heartport, Inc. System for cardiac procedures
US5707362A (en) * 1992-04-15 1998-01-13 Yoon; Inbae Penetrating instrument having an expandable anchoring portion for triggering protrusion of a safety member and/or retraction of a penetrating member
US5387227A (en) * 1992-09-10 1995-02-07 Grice; O. Drew Method for use of a laparo-suture needle
US5383904A (en) * 1992-10-13 1995-01-24 United States Surgical Corporation Stiffened surgical device
US5382259A (en) * 1992-10-26 1995-01-17 Target Therapeutics, Inc. Vasoocclusion coil with attached tubular woven or braided fibrous covering
US5488958A (en) * 1992-11-09 1996-02-06 Vance Products Incorporated Surgical cutting instrument for coring tissue affixed thereto
US6190373B1 (en) * 1992-11-13 2001-02-20 Scimed Life Systems, Inc. Axially detachable embolic coil assembly
US6346074B1 (en) * 1993-02-22 2002-02-12 Heartport, Inc. Devices for less invasive intracardiac interventions
US6010531A (en) * 1993-02-22 2000-01-04 Heartport, Inc. Less-invasive devices and methods for cardiac valve surgery
US5855614A (en) * 1993-02-22 1999-01-05 Heartport, Inc. Method and apparatus for thoracoscopic intracardiac procedures
US5282825A (en) * 1993-06-02 1994-02-01 Muck Kin C Surgical ligaturing and animal restraining device
US5593414A (en) * 1993-08-25 1997-01-14 Apollo Camera, L.L.C. Method of applying a surgical ligation clip
US5486187A (en) * 1994-01-04 1996-01-23 Schenck; Robert R. Anastomosis device and method
US5486197A (en) * 1994-03-24 1996-01-23 Ethicon, Inc. Two-piece suture anchor with barbs
US5603718A (en) * 1994-03-31 1997-02-18 Terumo Kabushiki Kaisha Suturing device
US5715987A (en) * 1994-04-05 1998-02-10 Tracor Incorporated Constant width, adjustable grip, staple apparatus and method
US5601571A (en) * 1994-05-17 1997-02-11 Moss; Gerald Surgical fastener implantation device
US6176413B1 (en) * 1994-06-17 2001-01-23 Heartport, Inc. Surgical anastomosis apparatus and method thereof
US5593424A (en) * 1994-08-10 1997-01-14 Segmed, Inc. Apparatus and method for reducing and stabilizing the circumference of a vascular structure
US5709695A (en) * 1994-08-10 1998-01-20 Segmed, Inc. Apparatus for reducing the circumference of a vascular structure
US5720755A (en) * 1995-01-18 1998-02-24 Dakov; Pepi Tubular suturing device and methods of use
US6171321B1 (en) * 1995-02-24 2001-01-09 Heartport, Inc. Devices and methods for performing a vascular anastomosis
US5591179A (en) * 1995-04-19 1997-01-07 Applied Medical Resources Corporation Anastomosis suturing device and method
US6013084A (en) * 1995-06-30 2000-01-11 Target Therapeutics, Inc. Stretch resistant vaso-occlusive coils (II)
US5601600A (en) * 1995-09-08 1997-02-11 Conceptus, Inc. Endoluminal coil delivery system having a mechanical release mechanism
US5709693A (en) * 1996-02-20 1998-01-20 Cardiothoracic System, Inc. Stitcher
US5716370A (en) * 1996-02-23 1998-02-10 Williamson, Iv; Warren Means for replacing a heart valve in a minimally invasive manner
US5871528A (en) * 1996-06-28 1999-02-16 Medtronic, Inc. Temporary bipolar heart wire
US6024748A (en) * 1996-07-23 2000-02-15 United States Surgical Corporation Singleshot anastomosis instrument with detachable loading unit and method
US5707380A (en) * 1996-07-23 1998-01-13 United States Surgical Corporation Anastomosis instrument and method
US6179848B1 (en) * 1996-07-24 2001-01-30 Jan Otto Solem Anastomotic fitting
US5868763A (en) * 1996-09-16 1999-02-09 Guidant Corporation Means and methods for performing an anastomosis
US6171320B1 (en) * 1996-12-25 2001-01-09 Niti Alloys Technologies Ltd. Surgical clip
US6022367A (en) * 1997-06-18 2000-02-08 United States Surgical Surgical apparatus for forming a hole in a blood vessel
US6346112B2 (en) * 1997-06-20 2002-02-12 Boston Scientific Corporation Hemostatic clips
US6193733B1 (en) * 1997-06-20 2001-02-27 Boston Scientific Corporation Hemostatic clips
US6193734B1 (en) * 1998-01-23 2001-02-27 Heartport, Inc. System for performing vascular anastomoses
US6176864B1 (en) * 1998-03-09 2001-01-23 Corvascular, Inc. Anastomosis device and method
US20060004389A1 (en) * 1998-06-03 2006-01-05 Medtronic, Inc. Multiple loop tissue connector apparatus and methods
US20070027461A1 (en) * 1998-06-03 2007-02-01 Barry Gardiner Tissue connector apparatus and methods
US6517558B2 (en) * 1999-01-15 2003-02-11 Ventrica, Inc. Methods and devices for forming vascular anastomoses
US7892255B2 (en) * 1999-03-01 2011-02-22 Medtronic, Inc. Tissue connector apparatus and methods
US20020010490A1 (en) * 1999-03-01 2002-01-24 Laurent Schaller Tissue connector apparatus and methods
US6350269B1 (en) * 1999-03-01 2002-02-26 Apollo Camera, L.L.C. Ligation clip and clip applier
US6514265B2 (en) * 1999-03-01 2003-02-04 Coalescent Surgical, Inc. Tissue connector apparatus with cable release
US6695859B1 (en) * 1999-04-05 2004-02-24 Coalescent Surgical, Inc. Apparatus and methods for anastomosis
US6183512B1 (en) * 1999-04-16 2001-02-06 Edwards Lifesciences Corporation Flexible annuloplasty system
US6179849B1 (en) * 1999-06-10 2001-01-30 Vascular Innovations, Inc. Sutureless closure for connecting a bypass graft to a target vessel
US6179840B1 (en) * 1999-07-23 2001-01-30 Ethicon, Inc. Graft fixation device and method
US6682540B1 (en) * 1999-11-05 2004-01-27 Onux Medical, Inc. Apparatus and method for placing multiple sutures
US6524338B1 (en) * 2000-08-25 2003-02-25 Steven R. Gundry Method and apparatus for stapling an annuloplasty band in-situ
US7335213B1 (en) * 2002-11-15 2008-02-26 Abbott Cardiovascular Systems Inc. Apparatus and methods for heart valve repair
US7335212B2 (en) * 2002-12-16 2008-02-26 Edrich Vascular Devices, Inc. Multiple stapling device for narrow blood vessels
US20050004582A1 (en) * 2002-12-16 2005-01-06 Edoga John K. Endovascular stapler
US20050021054A1 (en) * 2003-07-25 2005-01-27 Coalescent Surgical, Inc. Sealing clip, delivery systems, and methods
US7182769B2 (en) * 2003-07-25 2007-02-27 Medtronic, Inc. Sealing clip, delivery systems, and methods
US20070010835A1 (en) * 2003-08-22 2007-01-11 Tom Breton Eversion apparatus and methods
US20050043749A1 (en) * 2003-08-22 2005-02-24 Coalescent Surgical, Inc. Eversion apparatus and methods
US20090036903A1 (en) * 2007-05-05 2009-02-05 Arbor Surgical Technologies, Inc. Apparatus and methods for delivering fasteners during valve replacement
US20100044410A1 (en) * 2008-08-22 2010-02-25 Medtronic, Inc. Endovascular Stapling Apparatus and Methods of Use

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10792036B2 (en) 2017-11-15 2020-10-06 Winter Innovations, Llc Method and apparatus for double loop stitching
US11213290B2 (en) 2017-11-15 2022-01-04 Winter Innovations, Inc. Methods and systems for double loop stitching
US11026791B2 (en) 2018-03-20 2021-06-08 Medtronic Vascular, Inc. Flexible canopy valve repair systems and methods of use
US11285003B2 (en) 2018-03-20 2022-03-29 Medtronic Vascular, Inc. Prolapse prevention device and methods of use thereof
US11701228B2 (en) 2018-03-20 2023-07-18 Medtronic Vascular, Inc. Flexible canopy valve repair systems and methods of use
US11931261B2 (en) 2022-02-17 2024-03-19 Medtronic Vascular, Inc. Prolapse prevention device and methods of use thereof

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US7744611B2 (en) 2010-06-29
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US6926730B1 (en) 2005-08-09
AU2001296791A1 (en) 2002-04-22

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