US20090216246A1 - Ultrasound catheter devices and methods - Google Patents

Ultrasound catheter devices and methods Download PDF

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Publication number
US20090216246A1
US20090216246A1 US12/428,183 US42818309A US2009216246A1 US 20090216246 A1 US20090216246 A1 US 20090216246A1 US 42818309 A US42818309 A US 42818309A US 2009216246 A1 US2009216246 A1 US 2009216246A1
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ultrasound
catheter
transmission member
fluid
housing
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US8790291B2 (en
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Henry Nita
Jeff Sarge
Richard Spano
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FlowCardia Inc
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FlowCardia Inc
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Assigned to FLOWCARDIA, INC. reassignment FLOWCARDIA, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: NITA, HENRY, SARGE, JEFF, SPANO, RICHARD
Publication of US20090216246A1 publication Critical patent/US20090216246A1/en
Priority to US13/019,263 priority patent/US8617096B2/en
Priority to US14/090,926 priority patent/US10004520B2/en
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Publication of US8790291B2 publication Critical patent/US8790291B2/en
Priority to US15/997,056 priority patent/US10682151B2/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22004Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/225Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves
    • A61B17/2251Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves characterised by coupling elements between the apparatus, e.g. shock wave apparatus or locating means, and the patient, e.g. details of bags, pressure control of bag on patient
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22004Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
    • A61B17/22012Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00477Coupling
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22004Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
    • A61B17/22012Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement
    • A61B2017/22014Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement the ultrasound transducer being outside patient's body; with an ultrasound transmission member; with a wave guide; with a vibrated guide wire

Definitions

  • the present invention relates generally to medical devices and methods. More specifically, the present invention relates to ultrasound catheter devices and methods for treating occlusive intravascular lesions.
  • an ultrasonic catheter system for ablating occlusive material includes three basic components: an ultrasound generator, an ultrasound transducer, and an ultrasound catheter.
  • the generator converts line power into a high frequency current that is delivered to the transducer.
  • the transducer contains piezoelectric crystals which, when excited by the high frequency current, expand and contract at high frequency. These small, high-frequency expansions (relative to an axis of the transducer and the catheter) are amplified by the transducer horn into vibrational energy.
  • the vibrations are then transmitted from the transducer through the ultrasound catheter via an ultrasound transmission member (or wire) running longitudinally through the catheter.
  • the transmission member transmits the vibrational energy to the distal end of the catheter where the energy is used to ablate or otherwise disrupt a vascular obstruction.
  • ultrasound catheters of the type described above typically have lengths of about 150 cm or longer.
  • a sufficient amount of vibrational energy must be applied at the proximal end of the wire to provide a desired amount of energy at the distal end.
  • One continuing challenge in developing ultrasound catheters for treating vascular occlusions is to provide adequate vibrational energy at the distal end of a catheter device without overheating the ultrasound transmission wire.
  • increasing the amount of power input to the ultrasound transmission wire causes the temperature of the wire to increase. Overheating may occur anywhere along the length of the transmission wire, from its proximal connection with the ultrasound transducer to the distal tip of the wire. Overheating of the wire, along with the mechanical stresses placed on the wire from propagating ultrasound waves, can cause wire breakage, thus shortening the useful life of the catheter device.
  • Some ultrasound catheters use irrigation fluid to attempt to control the temperature of the ultrasound transmission wire, but such irrigation cooling techniques are not always effective.
  • Other devices use swapped frequencies to change frequency nodes and anti-nodes, thus moving a heat source from point to point along the transmission wire.
  • a given ultrasound transmission wire resonates at the fundamental frequency for which it is designed, and thus changing frequencies essentially requires turning the ultrasound device on and off, which reduces the efficacy of the device.
  • Some ultrasound catheter devices include one or more absorption members at the proximal end for absorbing unwanted vibrations of the ultrasound transmission wire. Such absorbers, however, do not address the heat generation issue and, in fact, may cause increased heating from frictional forces.
  • ultrasound catheters would provide a desired level of power at a distal end of the device while also preventing overheating of the device's ultrasound transmission member.
  • ultrasound transmission wire overheating at its proximal connection with a catheter device as well as along the length of the wire. At least some of these objectives will be met by the present invention.
  • an ultrasound catheter for disrupting occlusions in blood vessels includes: an elongate flexible catheter body having a proximal end, a distal end and at least one lumen; an ultrasound transmission member extending longitudinally through the lumen of the catheter body and having a proximal end and a distal end; a distal head coupled with the distal end of the ultrasound transmission member and disposed adjacent the distal end of the catheter body; a sonic connector coupled with the proximal end of the ultrasound transmission member for coupling the ultrasound transmission member with an ultrasound transducer device; and a proximal housing coupled with the proximal end of the catheter body and housing the sonic connector and a proximal portion of the ultrasound transmission wire.
  • the proximal housing includes at least one heat dissipation feature for dissipating heat from the proximal portion of the ultrasound transmission member.
  • the heat dissipation feature comprises one or more portions of the housing constructed of a heat conductive material.
  • the heat conductive material may include, but is not limited to, metal, polymer, glass, rubber, combinations thereof, or the like.
  • the heat dissipation feature may comprise multiple surface features on the housing to increase a surface area of the housing. Such surface features may include, for example, grooves, notches, waves, dips and/or the like.
  • an additional or alternative heat dissipation feature comprises at least one conductive material disposed within the housing, at least partially encircling the ultrasound transmission member, to conduct heat away from the ultrasound transmission member.
  • the conductive material may be disposed adjacent one or more vibration absorption members surrounding the ultrasound transmission member.
  • multiple separate conductive members may be disposed between multiple vibration absorption members to at least partially encircle the ultrasound transmission member.
  • the conductive material is arranged over one or more vibration absorption members surrounding the ultrasound transmission member.
  • the heat dissipation feature comprises at least one fluid inlet for allowing passage of one or more heat dissipating fluids into an inner cavity of the housing.
  • the inner cavity of the housing is in fluid communication with the lumen of the catheter body, such that fluid introduced into the inner cavity passes through and out a distal end of the catheter body lumen.
  • the inlet is disposed along the housing such that the heat dissipating fluid(s) passing through the inlet contact at least one vibration absorption member disposed over the ultrasound transmission member.
  • the inlet may also be disposed along the housing such that the heat dissipating fluid(s) passing through the inlet contact the sonic connector and a portion of the ultrasound transmission member.
  • Some devices further include a refrigeration device coupled with the catheter for refrigerating a fluid to be introduced through the fluid inlet.
  • the device may further include a guidewire tube extending through at least a portion of the catheter body for allowing passage of a guidewire.
  • a sidewall of the guidewire tube includes a plurality of apertures for allowing fluid introduced into the lumen of the catheter body to pass into and through the guidewire tube.
  • the proximal housing comprises a material adapted to change color when the temperature of the housing changes.
  • the material comprises a thermochromic pigment.
  • the thermochromic pigment in one embodiment, may change from a first color to a second color when the temperature of the housing reaches approximately 45° Celsius and changes from the second color to the first color when the temperature of the housing drops below approximately 45° Celsius.
  • an ultrasound catheter for disrupting occlusions in blood vessels includes: an elongate flexible catheter body having a proximal end, a distal end and at least one lumen; an ultrasound transmission member extending longitudinally through the lumen of the catheter body and having a proximal end and a distal end; a distal head coupled with the distal end of the ultrasound transmission member and disposed adjacent the distal end of the catheter body; a sonic connector coupled with the proximal end of the ultrasound transmission member for coupling the ultrasound transmission member with an ultrasound transducer device; a proximal housing coupled with the proximal end of the catheter body and housing the sonic connector and a proximal portion of the ultrasound transmission wire; and heat dissipation means for dissipating heat from the ultrasound transmission member.
  • heat dissipation means may include any suitable members, devices, attachments or the likes, such as but not limited to those described above. Any features described above may be applied to
  • an ultrasound catheter system for disrupting occlusions in blood vessels includes an ultrasound catheter device, an ultrasound generator removably coupled with the ultrasound catheter device, and a fluid cooling device removably coupled with the ultrasound catheter device for cooling one or more heat dissipating fluids to be passed through the catheter device.
  • the ultrasound catheter device itself includes: an elongate flexible catheter body having a proximal end, a distal end and at least one lumen; an ultrasound transmission member extending longitudinally through the lumen of the catheter body and having a proximal end and a distal end; a distal head coupled with the distal end of the ultrasound transmission member and disposed adjacent the distal end of the catheter body; a sonic connector coupled with the proximal end of the ultrasound transmission member for coupling the ultrasound transmission member with an ultrasound transducer device; and a proximal housing coupled with the proximal end of the catheter body and housing the sonic connector and a proximal portion of the ultrasound transmission wire.
  • the housing includes at least one fluid inlet for allowing passage of one or more heat dissipating fluids into an inner cavity of the housing.
  • the ultrasound catheter may include any of the features described above.
  • a method for disrupting an occlusion in a blood vessel involves positioning an ultrasound catheter in the blood vessel such that a distal end of the catheter is adjacent the occlusion; transmitting ultrasound energy to an ultrasound transmission member of the ultrasound catheter to disrupt the occlusion into multiple occlusion fragments, and passing a cooled irrigation fluid through the ultrasound catheter to dissipate heat away from the ultrasound transmission member.
  • the cooled fluid has a temperature between about 1° C. and about 22° C. Any suitable cooled fluid may be used, such as but not limited to saline, thrombolytic agents, antiplatelet drugs, lysing agents, anticoagulants and/or the like.
  • the method further involves cooling the irrigation fluid to a desired temperature, using a refrigeration device coupled with the ultrasound catheter.
  • cooled fluid is passed continuously through the ultrasound catheter during an occlusion disruption procedure.
  • the cooled fluid may be passed through the ultrasound catheter while the catheter is activated, with fluid passage being automatically stopped when the ultrasound catheter is deactivated.
  • a method for disrupting an occlusion in a blood vessel involves positioning an ultrasound catheter in the blood vessel such that a distal end of the catheter is adjacent the occlusion, transmitting ultrasound energy to an ultrasound transmission member of the ultrasound catheter to disrupt the occlusion into multiple occlusion fragments, and passing an oxygen supersaturated irrigation fluid through the ultrasound catheter to dissipate heat away from the ultrasound transmission member.
  • the oxygen supersaturated irrigation fluid comprises oxygen supersaturated saline solution.
  • the oxygen supersaturated irrigation fluid comprises saline solution combined with a radiopaque contrast material.
  • the oxygen supersaturead fluid may be kept at any suitable temperature. In some embodiments, the fluid is kept at room temperature, while in other embodiments it is kept at between about 1° C. and about 22° C.
  • a method for disrupting an occlusion in a blood vessel involves positioning an ultrasound catheter in the blood vessel such that a distal end of the catheter is adjacent the occlusion, transmitting ultrasound energy to an ultrasound transmission member of the ultrasound catheter to disrupt the occlusion into multiple occlusion fragments, and passing a lubricious irrigation fluid through the ultrasound catheter to dissipate heat away from the ultrasound transmission member and reduce friction between the ultrasound transmission member and an ultrasound catheter body.
  • the lubricious irrigation fluid comprises an emulsion.
  • the emulsion comprises olive oil, egg yolk, phospholipids, glycerin, sodium deoxycholate, L-histidine, disodium CDTA, sodium hydroxide and water.
  • the emulsion has a pH of between about 8.0 and about 9.0.
  • the lubricious fluid may be kept at any suitable temperature. In some embodiments, the fluid is kept at room temperature, while in other embodiments it is kept at between about 1° C. and about 22° C.
  • FIG. 1 is a perspective view of an ultrasound catheter system according to an embodiment of the present invention
  • FIG. 2 is a side view of an ultrasound catheter device according to an embodiment of the present invention.
  • FIG. 3 is cross-sectional side view of a proximal portion of an ultrasound catheter device having heat dissipation means according to an embodiment of the present invention
  • FIG. 4 is cross-sectional side view of a proximal portion of an ultrasound catheter device having heat dissipation means according to another embodiment of the present invention.
  • FIG. 5 is cross-sectional side view of a proximal portion of an ultrasound catheter device having heat dissipation means according to another embodiment of the present invention.
  • FIG. 6 is cross-sectional side view of a proximal portion of an ultrasound catheter device, with a proximal housing of the device having a fluid inlet aperture according to an embodiment of the present invention
  • FIG. 7 is cross-sectional side view of a proximal portion of an ultrasound catheter device, with a proximal housing of the device having a fluid inlet aperture according to another embodiment of the present invention.
  • FIG. 8 is a cross-sectional side view of a distal portion of an ultrasound catheter device having a perforated guidewire tube for allowing passage of fluid therethrough according to another embodiment of the present invention
  • Ultrasound catheter devices and methods of the present invention provide for disruption of occlusions in blood vessels.
  • Catheter devices generally include a catheter body, an ultrasound energy transmission member disposed within the catheter body and a distal head coupled with the energy transmission member and disposed at or near the distal end of the catheter body.
  • the ultrasound transmission member transmits ultrasound energy from an ultrasound transducer to the distal head, causing the head to vibrate and, thus, disrupt vascular occlusions.
  • an ultrasound catheter system 20 suitably includes an ultrasound catheter device 10 and an ultrasound generator 16 .
  • Catheter device 10 suitably includes a distal head 26 for disrupting occlusions, a catheter body 27 , and a proximal end connector 12 for coupling catheter device 10 with an ultrasound transducer 14 .
  • Ultrasound transducer 14 is coupled with ultrasound generator 16 via a connector 28
  • generator is coupled with a foot-actuated on/off switch 18 via another connector 29 .
  • Generator 16 provides ultrasonic energy to transducer 14 and, thus, to ultrasound catheter 10 .
  • Catheter device 10 further includes an ultrasound transmission member (or “wire”—not shown) that extends through the catheter body 27 and transmits energy from the transducer 14 to the distal head 26 .
  • Some embodiments of device 10 include a rapid exchange guidewire 13 and guidewire port, while other embodiments include a proximal guidewire port for over the wire guidewire delivery.
  • transducer 14 further includes a securing device 15 for enhancing coupling of catheter 10 to transducer 14 .
  • the various components of system 20 may be coupled via any suitable means.
  • Connectors 28 , 29 may comprise an electric cord or cable or any other suitable connecting devices for coupling on/off switch 18 , generator 16 and transducer 14 .
  • on/off switch 18 is located on generator 16 .
  • ultrasound catheter device 10 may include one or more other various components, such as a Y-connector 11 including a fluid inlet port 17 (or aperture) for passage of irrigation fluid.
  • Inlet port 17 may be removably coupled with an irrigation tube 24 , which in one embodiment may be coupled with a fluid refrigeration (or “fluid cooling”) device 30 .
  • Refrigeration device 30 may, in turn, be coupled with a fluid container 32 via a connector tube 34 .
  • This irrigation apparatus may be used for introducing one or more fluids into catheter device 10 . Fluid may be used to cool any part of the device, such as the ultrasound transmission member, thus helping reduce wear and tear of device 10 .
  • fluid inlet port 17 is located farther proximally on proximal connector 12 , to allow fluid to be applied within connector 12 .
  • refrigerated fluid is used, while in other embodiments irrigation fluid may be kept at room temperature.
  • oxygen supersaturated fluid, lubricious fluid, or any other suitable fluid or combination of fluids may be used, and again, such fluids may be refrigerated or kept room temperature.
  • refrigeration device 30 and fluid container 32 are combined in one device.
  • catheter device 10 may include any suitable number of side-arms or ports for passage of a guidewire, application of suction, infusing and/or withdrawing irrigation fluid, dye and/or the like, or any other suitable ports or connections.
  • ultrasound catheters 10 of the present invention may be used with any suitable proximal devices, such as any suitable ultrasound transducer 14 , ultrasound generator 16 , coupling device(s) and/or the like. Therefore, the exemplary embodiment shown in FIG. 1 and any following descriptions of proximal apparatus or systems for use with ultrasound catheters 10 should not be interpreted to limit the scope of the present invention as defined in the appended claims.
  • catheter body 27 is generally a flexible, tubular, elongate member, having any suitable diameter and length for reaching a vascular occlusion for treatment.
  • catheter body 27 preferably has an outer diameter of between about 0.5 mm and about 5.0 mm.
  • catheter body 27 may have an outer diameter of between about 0.25 mm and about 2.5 mm.
  • Catheter body 27 may also have any suitable length.
  • some ultrasound catheters have a length in the range of about 150 cm.
  • any other suitable length may be used without departing from the scope of the present invention.
  • catheter bodies similar to those which may be used in the present invention are described in U.S. Pat. Nos. 5,267,954 and 5,989,208, which were previously incorporated herein by reference.
  • an ultrasound transmission wire 140 extends from a sonic connector 152 distally to a distal end (not shown) of catheter device 110 .
  • a catheter body 127 of device 110 is shown only in part, whereas catheter body 127 typically extends distally to (or near) the distal end of device 110 .
  • Catheter device 110 also includes a proximal housing 112 (or “proximal connector”), having an inner bore 144 (or “inner cavity”) in which sonic connector 152 , a portion of ultrasound transmission member 140 and one or more vibration absorption members 150 reside. Housing 112 is coupled with a Y-connector 111 , which includes a fluid inlet port 117 (or aperture), and Y-connector 111 is coupled with catheter body 127 .
  • housing 112 may suitably include one or more surface features 142 for increasing the overall surface area of the outer surface of housing 112 . Increased surface area enhances the ability of housing 112 to dissipate heat generated by ultrasound transmission member 140 out of catheter device 110 .
  • Surface features 142 may have any suitable size or shape, such as ridges, jags, undulations, grooves or the like, and any suitable number of surface features 142 may be used.
  • housing 112 may be made of one or more heat dissipating materials, such as aluminum, stainless steel, any other conductive metal(s), or any suitable non-metallic conductive material(s).
  • ultrasound transmission member 140 extends longitudinally through a lumen of catheter body 127 to transmit ultrasonic energy from an ultrasound transducer (not shown), connected to the proximal end of proximal housing 112 , to the distal end of catheter device 110 .
  • Ultrasound transmission member 140 may be formed of any material capable of effectively transmitting ultrasonic energy from the ultrasound transducer to the distal end of catheter body 127 , including but not limited to metals such as pure titanium or aluminum, or titanium or aluminum alloys. Again, additional details of ultrasound transmission members 140 may be found in the patent applications incorporated by reference above.
  • housing 112 Similarly, reference may be made to the incorporated patent applications for descriptions of housing 112 , sonic connector 152 , vibration absorption members 150 , Y-connector 111 and the like.
  • housing 112 and other features are described in detail in Ser. No. 10/722,209, filed Nov. 24, 2003, entitled “Steerable Ultrasound Catheter” (Attorney Docket No. 021577-000900US), which was previously incorporated by reference.
  • Ultrasound transmission member 140 typically passes from sonic connector 152 , through bore 144 and Y-connector 111 , and then through catheter body 127 .
  • Fluid inlet port 117 is in fluid communication with a lumen in Y-connector, which is in fluid communication with a lumen extending through catheter body 127 .
  • Fluid introduced into fluid inlet port 117 is typically free to flow into and through catheter body 127 to contact ultrasound transmission member 140 .
  • Fluid may flow out of catheter body 127 through apertures in the distal head (not shown) or through any other suitable apertures or openings, such as apertures located in catheter body 127 itself.
  • any suitable fluid may be passed through fluid inlet port 117 and catheter body 127 , such as refrigerated fluid, lubricious fluid, super-saturated saline or contrast/saline mixture, or the like. Cooling and/or lubricating ultrasound transmission member 140 may reduce friction and/or wear and tear of ultrasound transmission member 140 , thus prolonging the useful life of ultrasound catheter device 110 and enhancing its performance.
  • the temperature and flow rate of a coolant liquid may be specifically controlled to maintain the temperature of ultrasound transmission member 140 at a desired temperature within its optimal working range.
  • ultrasound transmission member 140 is formed of a metal alloy which exhibits optimal physical properties (e.g. super elasticity) within a specific range of temperatures
  • the temperature and flow rate of coolant liquid infused through fluid inlet port 117 may be specifically controlled to maintain the temperature of ultrasound transmission member 140 within a range of temperatures at which it demonstrates its most desirable physical properties.
  • ultrasound transmission member 140 is formed of a shape memory alloy which exhibits super-elasticity when in its martensite state, but which loses super-elasticity as it transitions to an austenite state
  • the temperature at which such shape memory alloys transition from a martensite state to an austenite state is known as the “martensite transition temperature” of the material.
  • the fluid infused through port 117 will be at such temperature, and will be infused at such rate, as to maintain the shape memory alloy of ultrasound transmission member 140 below its martensite transition temperature.
  • a super-saturated fluid may be used.
  • Use of such fluids may enhance cavitation of an occlusion, help prevent unwanted tissue damage and/or the like.
  • Such fluids are described, for example, in U.S. Pat. Nos.
  • an ultrasound catheter device 210 includes the features described immediately above and also includes a heat absorbing member 160 disposed within housing 112 .
  • Heat absorbing member 160 may have any suitable shape and size and may, in various embodiments, be disposed in any of a number of different locations within housing 112 .
  • heat absorbing member 160 is made of a heat absorbing material, such as but not limited to a metalized elastomer, such as a rubber material combined with a metallic powder such as aluminum powder.
  • a metalized elastomer such as a rubber material combined with a metallic powder such as aluminum powder.
  • any other suitable heat sink or heat absorption material may be used, in alternative embodiments.
  • heat absorbing member 160 is generally cylindrical in shape and is disposed around vibration absorption members 150 , so that it absorbs heat from ultrasound transmission member 140 and vibration absorbers 150 .
  • an ultrasound catheter device 310 may include multiple heat absorption members 170 , such as cylindrical members disposed around ultrasound transmission member 140 and in between multiple vibration absorption members 150 . As is evident from FIGS. 4 and 5 , any of a number of configurations of heat absorption members 160 , 170 may be disposed within housing 112 .
  • FIG. 6 demonstrates another embodiment of an ultrasound catheter device 410 , which may include any of the features described above.
  • a fluid inlet port 217 is located farther proximally on housing 112 than in the earlier-described embodiments. Fluid inlet port 217 is in fluid communication with inner cavity 144 of housing 112 , so that fluid (solid-tipped arrows) introduced into fluid inlet port 217 enters inner cavity 144 and contacts vibration absorption members 150 before entering the lumen of catheter body 127 via one or more proximal apertures 220 . Fluid passing along and contacting vibration absorption members 150 will help dissipate heat from the members 150 .
  • such fluids may be refrigerated/cooled, lubricious, oxygen supersaturated or the like. Lubricious and oxygen supersaturated fluids, in various embodiments, may be either cooled/refrigerated or at room temperature.
  • an ultrasound catheter device 510 includes all the features just described, but fluid inlet port 317 is located farther proximally on housing 112 .
  • fluid (solid-tipped arrows) entering fluid inlet port 317 contacts a proximal portion of ultrasound transmission member 140 , proceeds distally to contact vibration absorption members 150 , and then proceeds through apertures 220 into the lumen of catheter body 127 .
  • the fluid provides extra heat dissipation to the proximal portion of ultrasound transmission member 140 with which it comes in contact.
  • an ultrasound catheter device 610 may include a guidewire tube 424 that forms a guidewire lumen 426 and that includes one or more guidewire tube apertures 430 for allowing passage of fluid.
  • a guidewire 420 may be passed through guidewire lumen 426 and out a distal aperture 422 of guidewire tube 424 , located in distal head 26 .
  • Fluid (solid-tipped arrows) that is passed through a catheter body lumen 428 may flow into apertures 430 and out distal aperture 422 .
  • the fluid would thus contact ultrasound transmission member 140 during a portion of its journey through catheter body lumen 428 , thus dissipating heat and/or lubricating, and would then pass out of catheter device 610 via guidewire tube 424 .
  • This configuration may be advantageous in that irrigation fluid may provide an additional lubrication inside guidewire lumen 426 to improve guidewire movement.
  • housing 112 may include a material that changes color when its temperature increases or decreases, thus providing an indication of the temperature of the proximal portion of the catheter device.
  • a thermochromic material such as Colorcomp® Thermochromics (provided by LNP Engineering Plastics, Inc.) may be used. Other color-change materials may be used in alternative embodiments.
  • the color of such material may change at any suitable temperatures.
  • the thermochromic pigment changes from a first color to a second color when the temperature of housing 112 reaches approximately 45° Celsius and changes from the second color to the first color when the temperature of housing 112 drops below approximately 45° Celsius.

Abstract

Ultrasound catheter devices and methods provide enhanced disruption of blood vessel obstructions. Generally, an ultrasound catheter device includes an elongate flexible catheter body with one or more lumens, an ultrasound transmission member extending longitudinally through the catheter body lumen and a distal head coupled with the transmission member and positioned adjacent the distal end of the catheter body for disrupting occlusions. A proximal housing of the catheter device may include one or more features for dissipating heat from the ultrasound transmission wire, such as a fluid inlet aperture for passage of fluid, use of heat conductive materials in the proximal housing, surface features to increase the housing's surface area, heat conductive members disposed adjacent the transmission member and the like. Various irrigation fluids may be used, such as cooled, oxygen supersaturated or lubricious fluids.

Description

  • This application is related to the following U.S. patent application Ser. Nos.: 10/229,371, filed Aug. 26, 2002, entitled “Ultrasound Catheter for Disrupting Blood Vessel Obstructions” (Attorney Docket No. 021577-000400US); 10/345,078, filed Jan. 14, 2003, entitled “Ultrasound Catheter and Methods for Making and Using Same” (Attorney Docket No. 021577-000600US); 10/375,903, filed Feb. 26, 2003, entitled “Ultrasound Catheter Apparatus” (Attorney Docket No. 021577-000700US); 10/410,617, filed Apr. 8, 2003, entitled “Improved Ultrasound Catheter Devices and Methods” (Attorney Docket No. 021577-000800US); and 10/722,209, filed Nov. 24, 2003, entitled “Steerable Ultrasound Catheter” (Attorney Docket No. 021577-000900US). The full disclosures of all of the above-listed patent applications are all hereby incorporated by reference.
  • BACKGROUND OF THE INVENTION
  • The present invention relates generally to medical devices and methods. More specifically, the present invention relates to ultrasound catheter devices and methods for treating occlusive intravascular lesions.
  • Catheters employing various types of ultrasound transmitting members have been successfully used to ablate or otherwise disrupt obstructions in blood vessels. Specifically, ablation of atherosclerotic plaque or thromboembolic obstructions from peripheral blood vessels such as the femoral arteries has been particularly successful. Various ultrasonic catheter devices have been developed for use in ablating or otherwise removing obstructive material from blood vessels. For example, U.S. Pat. Nos. 5,267,954 and 5,380,274, issued to an inventor of the present invention and hereby incorporated by reference, describe ultrasound catheter devices for removing occlusions. Other examples of ultrasonic ablation devices for removing obstructions from blood vessels include those described in U.S. Pat. No. 3,433,226 (Boyd), U.S. Pat. No. 3,823,717 (Pohlman, et al.), U.S. Pat. No. 4,808,153 (Parisi), U.S. Pat. No. 4,936,281 (Stasz), U.S. Pat. No. 3,565,062 (Kuris), U.S. Pat. No. 4,924,863 (Sterzer), U.S. Pat. No. 4,870,953 (Don Michael, et al), and U.S. Pat. No. 4,920,954 (Alliger, et al.), as well as other patent publications W087-05739 (Cooper), W089-06515 (Bernstein, et al.), W090-0130 (Sonic Needle Corp.), EP316789 (Don Michael, et al.), DE3,821,836 (Schubert) and DE2438648 (Pohlman). While many ultrasound catheters have been developed, however, improvements are still being pursued.
  • Typically, an ultrasonic catheter system for ablating occlusive material includes three basic components: an ultrasound generator, an ultrasound transducer, and an ultrasound catheter. The generator converts line power into a high frequency current that is delivered to the transducer. The transducer contains piezoelectric crystals which, when excited by the high frequency current, expand and contract at high frequency. These small, high-frequency expansions (relative to an axis of the transducer and the catheter) are amplified by the transducer horn into vibrational energy. The vibrations are then transmitted from the transducer through the ultrasound catheter via an ultrasound transmission member (or wire) running longitudinally through the catheter. The transmission member transmits the vibrational energy to the distal end of the catheter where the energy is used to ablate or otherwise disrupt a vascular obstruction.
  • To effectively reach various sites for treatment of intravascular occlusions, ultrasound catheters of the type described above typically have lengths of about 150 cm or longer. To permit the advancement of such ultrasound catheters through small and/or tortuous blood vessels such as the aortic arch, coronary vessels, and peripheral vasculature of the lower extremities, the catheters (and their respective ultrasound transmission wires) must typically be sufficiently small and flexible. Also, due to attenuation of ultrasound energy along the long, thin, ultrasound transmission wire, a sufficient amount of vibrational energy must be applied at the proximal end of the wire to provide a desired amount of energy at the distal end.
  • One continuing challenge in developing ultrasound catheters for treating vascular occlusions is to provide adequate vibrational energy at the distal end of a catheter device without overheating the ultrasound transmission wire. Generally, increasing the amount of power input to the ultrasound transmission wire causes the temperature of the wire to increase. Overheating may occur anywhere along the length of the transmission wire, from its proximal connection with the ultrasound transducer to the distal tip of the wire. Overheating of the wire, along with the mechanical stresses placed on the wire from propagating ultrasound waves, can cause wire breakage, thus shortening the useful life of the catheter device. Furthermore, it is generally desirable to ablate an occlusion via the ultrasound vibrations and not by heating the occlusion, since heating causes a denaturalization process that reduces the efficacy of the ultrasound ablation.
  • Some ultrasound catheters use irrigation fluid to attempt to control the temperature of the ultrasound transmission wire, but such irrigation cooling techniques are not always effective. Other devices use swapped frequencies to change frequency nodes and anti-nodes, thus moving a heat source from point to point along the transmission wire. However, a given ultrasound transmission wire resonates at the fundamental frequency for which it is designed, and thus changing frequencies essentially requires turning the ultrasound device on and off, which reduces the efficacy of the device. Some ultrasound catheter devices include one or more absorption members at the proximal end for absorbing unwanted vibrations of the ultrasound transmission wire. Such absorbers, however, do not address the heat generation issue and, in fact, may cause increased heating from frictional forces.
  • Therefore, a need exists for improved ultrasound catheter devices and methods that provide ablation or disruption of vascular occlusions. Ideally, such ultrasound catheters would provide a desired level of power at a distal end of the device while also preventing overheating of the device's ultrasound transmission member. Ideally, such devices would address ultrasound transmission wire overheating at its proximal connection with a catheter device as well as along the length of the wire. At least some of these objectives will be met by the present invention.
  • BRIEF SUMMARY OF THE INVENTION
  • In one aspect of the invention, an ultrasound catheter for disrupting occlusions in blood vessels includes: an elongate flexible catheter body having a proximal end, a distal end and at least one lumen; an ultrasound transmission member extending longitudinally through the lumen of the catheter body and having a proximal end and a distal end; a distal head coupled with the distal end of the ultrasound transmission member and disposed adjacent the distal end of the catheter body; a sonic connector coupled with the proximal end of the ultrasound transmission member for coupling the ultrasound transmission member with an ultrasound transducer device; and a proximal housing coupled with the proximal end of the catheter body and housing the sonic connector and a proximal portion of the ultrasound transmission wire. The proximal housing includes at least one heat dissipation feature for dissipating heat from the proximal portion of the ultrasound transmission member.
  • In some embodiments, the heat dissipation feature comprises one or more portions of the housing constructed of a heat conductive material. For example, the heat conductive material may include, but is not limited to, metal, polymer, glass, rubber, combinations thereof, or the like. Additionally (or alternatively), the heat dissipation feature may comprise multiple surface features on the housing to increase a surface area of the housing. Such surface features may include, for example, grooves, notches, waves, dips and/or the like. In some embodiments, an additional or alternative heat dissipation feature comprises at least one conductive material disposed within the housing, at least partially encircling the ultrasound transmission member, to conduct heat away from the ultrasound transmission member. In one embodiment, the conductive material may be disposed adjacent one or more vibration absorption members surrounding the ultrasound transmission member. Optionally, multiple separate conductive members may be disposed between multiple vibration absorption members to at least partially encircle the ultrasound transmission member. In another embodiment, the conductive material is arranged over one or more vibration absorption members surrounding the ultrasound transmission member.
  • In some embodiments, the heat dissipation feature comprises at least one fluid inlet for allowing passage of one or more heat dissipating fluids into an inner cavity of the housing. In some embodiments, the inner cavity of the housing is in fluid communication with the lumen of the catheter body, such that fluid introduced into the inner cavity passes through and out a distal end of the catheter body lumen. In some embodiments, the inlet is disposed along the housing such that the heat dissipating fluid(s) passing through the inlet contact at least one vibration absorption member disposed over the ultrasound transmission member. The inlet may also be disposed along the housing such that the heat dissipating fluid(s) passing through the inlet contact the sonic connector and a portion of the ultrasound transmission member. Some devices further include a refrigeration device coupled with the catheter for refrigerating a fluid to be introduced through the fluid inlet. Optionally, the device may further include a guidewire tube extending through at least a portion of the catheter body for allowing passage of a guidewire. In one embodiment, a sidewall of the guidewire tube includes a plurality of apertures for allowing fluid introduced into the lumen of the catheter body to pass into and through the guidewire tube.
  • In some embodiments, at least a portion of the proximal housing comprises a material adapted to change color when the temperature of the housing changes. In one embodiment, for example, the material comprises a thermochromic pigment. The thermochromic pigment, in one embodiment, may change from a first color to a second color when the temperature of the housing reaches approximately 45° Celsius and changes from the second color to the first color when the temperature of the housing drops below approximately 45° Celsius.
  • In another aspect of the present invention, an ultrasound catheter for disrupting occlusions in blood vessels includes: an elongate flexible catheter body having a proximal end, a distal end and at least one lumen; an ultrasound transmission member extending longitudinally through the lumen of the catheter body and having a proximal end and a distal end; a distal head coupled with the distal end of the ultrasound transmission member and disposed adjacent the distal end of the catheter body; a sonic connector coupled with the proximal end of the ultrasound transmission member for coupling the ultrasound transmission member with an ultrasound transducer device; a proximal housing coupled with the proximal end of the catheter body and housing the sonic connector and a proximal portion of the ultrasound transmission wire; and heat dissipation means for dissipating heat from the ultrasound transmission member. According to various embodiments, heat dissipation means may include any suitable members, devices, attachments or the likes, such as but not limited to those described above. Any features described above may be applied to this ultrasound catheter.
  • In another aspect of the present invention, an ultrasound catheter system for disrupting occlusions in blood vessels includes an ultrasound catheter device, an ultrasound generator removably coupled with the ultrasound catheter device, and a fluid cooling device removably coupled with the ultrasound catheter device for cooling one or more heat dissipating fluids to be passed through the catheter device. The ultrasound catheter device itself includes: an elongate flexible catheter body having a proximal end, a distal end and at least one lumen; an ultrasound transmission member extending longitudinally through the lumen of the catheter body and having a proximal end and a distal end; a distal head coupled with the distal end of the ultrasound transmission member and disposed adjacent the distal end of the catheter body; a sonic connector coupled with the proximal end of the ultrasound transmission member for coupling the ultrasound transmission member with an ultrasound transducer device; and a proximal housing coupled with the proximal end of the catheter body and housing the sonic connector and a proximal portion of the ultrasound transmission wire. The housing includes at least one fluid inlet for allowing passage of one or more heat dissipating fluids into an inner cavity of the housing. Again, the ultrasound catheter may include any of the features described above.
  • In another aspect of the present invention, a method for disrupting an occlusion in a blood vessel involves positioning an ultrasound catheter in the blood vessel such that a distal end of the catheter is adjacent the occlusion; transmitting ultrasound energy to an ultrasound transmission member of the ultrasound catheter to disrupt the occlusion into multiple occlusion fragments, and passing a cooled irrigation fluid through the ultrasound catheter to dissipate heat away from the ultrasound transmission member. In some embodiments, for example, the cooled fluid has a temperature between about 1° C. and about 22° C. Any suitable cooled fluid may be used, such as but not limited to saline, thrombolytic agents, antiplatelet drugs, lysing agents, anticoagulants and/or the like. In some embodiments, the method further involves cooling the irrigation fluid to a desired temperature, using a refrigeration device coupled with the ultrasound catheter. In one embodiment, cooled fluid is passed continuously through the ultrasound catheter during an occlusion disruption procedure. Alternatively, the cooled fluid may be passed through the ultrasound catheter while the catheter is activated, with fluid passage being automatically stopped when the ultrasound catheter is deactivated.
  • In another aspect of the present invention, a method for disrupting an occlusion in a blood vessel involves positioning an ultrasound catheter in the blood vessel such that a distal end of the catheter is adjacent the occlusion, transmitting ultrasound energy to an ultrasound transmission member of the ultrasound catheter to disrupt the occlusion into multiple occlusion fragments, and passing an oxygen supersaturated irrigation fluid through the ultrasound catheter to dissipate heat away from the ultrasound transmission member. In some embodiments, for example, the oxygen supersaturated irrigation fluid comprises oxygen supersaturated saline solution. In other embodiments, the oxygen supersaturated irrigation fluid comprises saline solution combined with a radiopaque contrast material. The oxygen supersaturead fluid may be kept at any suitable temperature. In some embodiments, the fluid is kept at room temperature, while in other embodiments it is kept at between about 1° C. and about 22° C.
  • In another aspect of the present invention, a method for disrupting an occlusion in a blood vessel involves positioning an ultrasound catheter in the blood vessel such that a distal end of the catheter is adjacent the occlusion, transmitting ultrasound energy to an ultrasound transmission member of the ultrasound catheter to disrupt the occlusion into multiple occlusion fragments, and passing a lubricious irrigation fluid through the ultrasound catheter to dissipate heat away from the ultrasound transmission member and reduce friction between the ultrasound transmission member and an ultrasound catheter body. For example, in some embodiments, the lubricious irrigation fluid comprises an emulsion. In one embodiment, the emulsion comprises olive oil, egg yolk, phospholipids, glycerin, sodium deoxycholate, L-histidine, disodium CDTA, sodium hydroxide and water. In some embodiments, the emulsion has a pH of between about 8.0 and about 9.0. The lubricious fluid may be kept at any suitable temperature. In some embodiments, the fluid is kept at room temperature, while in other embodiments it is kept at between about 1° C. and about 22° C.
  • These and other aspects and embodiments of the present invention are described in further detail below, in reference to the attached drawing figures.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • FIG. 1 is a perspective view of an ultrasound catheter system according to an embodiment of the present invention;
  • FIG. 2 is a side view of an ultrasound catheter device according to an embodiment of the present invention;
  • FIG. 3 is cross-sectional side view of a proximal portion of an ultrasound catheter device having heat dissipation means according to an embodiment of the present invention;
  • FIG. 4 is cross-sectional side view of a proximal portion of an ultrasound catheter device having heat dissipation means according to another embodiment of the present invention;
  • FIG. 5 is cross-sectional side view of a proximal portion of an ultrasound catheter device having heat dissipation means according to another embodiment of the present invention;
  • FIG. 6 is cross-sectional side view of a proximal portion of an ultrasound catheter device, with a proximal housing of the device having a fluid inlet aperture according to an embodiment of the present invention;
  • FIG. 7 is cross-sectional side view of a proximal portion of an ultrasound catheter device, with a proximal housing of the device having a fluid inlet aperture according to another embodiment of the present invention; and
  • FIG. 8 is a cross-sectional side view of a distal portion of an ultrasound catheter device having a perforated guidewire tube for allowing passage of fluid therethrough according to another embodiment of the present invention
  • DETAILED DESCRIPTION OF THE INVENTION
  • Ultrasound catheter devices and methods of the present invention provide for disruption of occlusions in blood vessels. Catheter devices generally include a catheter body, an ultrasound energy transmission member disposed within the catheter body and a distal head coupled with the energy transmission member and disposed at or near the distal end of the catheter body. The ultrasound transmission member transmits ultrasound energy from an ultrasound transducer to the distal head, causing the head to vibrate and, thus, disrupt vascular occlusions. A number of improved features of such ultrasound catheter devices are described more fully below.
  • Referring now to FIG. 1, one embodiment of an ultrasound catheter system 20 suitably includes an ultrasound catheter device 10 and an ultrasound generator 16. Catheter device 10 suitably includes a distal head 26 for disrupting occlusions, a catheter body 27, and a proximal end connector 12 for coupling catheter device 10 with an ultrasound transducer 14. Ultrasound transducer 14 is coupled with ultrasound generator 16 via a connector 28, and generator is coupled with a foot-actuated on/off switch 18 via another connector 29. Generator 16 provides ultrasonic energy to transducer 14 and, thus, to ultrasound catheter 10. Catheter device 10 further includes an ultrasound transmission member (or “wire”—not shown) that extends through the catheter body 27 and transmits energy from the transducer 14 to the distal head 26. Some embodiments of device 10 include a rapid exchange guidewire 13 and guidewire port, while other embodiments include a proximal guidewire port for over the wire guidewire delivery. In some embodiments, transducer 14 further includes a securing device 15 for enhancing coupling of catheter 10 to transducer 14. The various components of system 20 may be coupled via any suitable means. Connectors 28, 29 may comprise an electric cord or cable or any other suitable connecting devices for coupling on/off switch 18, generator 16 and transducer 14. In an alternative embodiment, on/off switch 18 is located on generator 16.
  • In addition to proximal connector 12, ultrasound catheter device 10 may include one or more other various components, such as a Y-connector 11 including a fluid inlet port 17 (or aperture) for passage of irrigation fluid. Inlet port 17 may be removably coupled with an irrigation tube 24, which in one embodiment may be coupled with a fluid refrigeration (or “fluid cooling”) device 30. Refrigeration device 30 may, in turn, be coupled with a fluid container 32 via a connector tube 34. This irrigation apparatus may be used for introducing one or more fluids into catheter device 10. Fluid may be used to cool any part of the device, such as the ultrasound transmission member, thus helping reduce wear and tear of device 10. In some embodiments, fluid inlet port 17 is located farther proximally on proximal connector 12, to allow fluid to be applied within connector 12. In some embodiments, refrigerated fluid is used, while in other embodiments irrigation fluid may be kept at room temperature. In various embodiments, oxygen supersaturated fluid, lubricious fluid, or any other suitable fluid or combination of fluids may be used, and again, such fluids may be refrigerated or kept room temperature. In an alternative embodiment to that shown in FIG. 1, refrigeration device 30 and fluid container 32 are combined in one device.
  • Generally, catheter device 10 may include any suitable number of side-arms or ports for passage of a guidewire, application of suction, infusing and/or withdrawing irrigation fluid, dye and/or the like, or any other suitable ports or connections. Also, ultrasound catheters 10 of the present invention may be used with any suitable proximal devices, such as any suitable ultrasound transducer 14, ultrasound generator 16, coupling device(s) and/or the like. Therefore, the exemplary embodiment shown in FIG. 1 and any following descriptions of proximal apparatus or systems for use with ultrasound catheters 10 should not be interpreted to limit the scope of the present invention as defined in the appended claims.
  • Referring now to FIG. 2, an enlarged view of catheter device 10 is shown. Proximal connector 12, Y-connector 11, inlet port 17, catheter body 27, distal head 26 and guidewire 13 are all shown. Catheter body 27 is generally a flexible, tubular, elongate member, having any suitable diameter and length for reaching a vascular occlusion for treatment. In one embodiment, for example, catheter body 27 preferably has an outer diameter of between about 0.5 mm and about 5.0 mm. In other embodiments, as in catheters intended for use in relatively small vessels, catheter body 27 may have an outer diameter of between about 0.25 mm and about 2.5 mm. Catheter body 27 may also have any suitable length. As discussed briefly above, for example, some ultrasound catheters have a length in the range of about 150 cm. However, any other suitable length may be used without departing from the scope of the present invention. Examples of catheter bodies similar to those which may be used in the present invention are described in U.S. Pat. Nos. 5,267,954 and 5,989,208, which were previously incorporated herein by reference.
  • Features of the present invention may be applied to any of a number of ultrasound catheter devices. For more detailed description of exemplary ultrasound catheter devices, reference may be made to U.S. patent application Ser. Nos. 10/229,371, 10/345,078, 10/375,903, 10/410,617 and 10/722,209, which were all previously incorporated by reference. In various alternative embodiments, aspects of the present invention may be applied to any other suitable catheter devices.
  • Referring now to FIG. 3, a proximal portion of one embodiment of an ultrasound catheter device 110 is shown in cross-section. An ultrasound transmission wire 140 extends from a sonic connector 152 distally to a distal end (not shown) of catheter device 110. A catheter body 127 of device 110 is shown only in part, whereas catheter body 127 typically extends distally to (or near) the distal end of device 110. Catheter device 110 also includes a proximal housing 112 (or “proximal connector”), having an inner bore 144 (or “inner cavity”) in which sonic connector 152, a portion of ultrasound transmission member 140 and one or more vibration absorption members 150 reside. Housing 112 is coupled with a Y-connector 111, which includes a fluid inlet port 117 (or aperture), and Y-connector 111 is coupled with catheter body 127.
  • In various embodiments, housing 112 may suitably include one or more surface features 142 for increasing the overall surface area of the outer surface of housing 112. Increased surface area enhances the ability of housing 112 to dissipate heat generated by ultrasound transmission member 140 out of catheter device 110. Surface features 142 may have any suitable size or shape, such as ridges, jags, undulations, grooves or the like, and any suitable number of surface features 142 may be used. Additionally, housing 112 may be made of one or more heat dissipating materials, such as aluminum, stainless steel, any other conductive metal(s), or any suitable non-metallic conductive material(s).
  • In most embodiments, ultrasound transmission member 140, wire, or wave guide extends longitudinally through a lumen of catheter body 127 to transmit ultrasonic energy from an ultrasound transducer (not shown), connected to the proximal end of proximal housing 112, to the distal end of catheter device 110. Ultrasound transmission member 140 may be formed of any material capable of effectively transmitting ultrasonic energy from the ultrasound transducer to the distal end of catheter body 127, including but not limited to metals such as pure titanium or aluminum, or titanium or aluminum alloys. Again, additional details of ultrasound transmission members 140 may be found in the patent applications incorporated by reference above. Similarly, reference may be made to the incorporated patent applications for descriptions of housing 112, sonic connector 152, vibration absorption members 150, Y-connector 111 and the like. For example, housing 112 and other features are described in detail in Ser. No. 10/722,209, filed Nov. 24, 2003, entitled “Steerable Ultrasound Catheter” (Attorney Docket No. 021577-000900US), which was previously incorporated by reference.
  • Ultrasound transmission member 140 typically passes from sonic connector 152, through bore 144 and Y-connector 111, and then through catheter body 127. Fluid inlet port 117 is in fluid communication with a lumen in Y-connector, which is in fluid communication with a lumen extending through catheter body 127. Thus, fluid introduced into fluid inlet port 117 is typically free to flow into and through catheter body 127 to contact ultrasound transmission member 140. Fluid may flow out of catheter body 127 through apertures in the distal head (not shown) or through any other suitable apertures or openings, such as apertures located in catheter body 127 itself. Any suitable fluid may be passed through fluid inlet port 117 and catheter body 127, such as refrigerated fluid, lubricious fluid, super-saturated saline or contrast/saline mixture, or the like. Cooling and/or lubricating ultrasound transmission member 140 may reduce friction and/or wear and tear of ultrasound transmission member 140, thus prolonging the useful life of ultrasound catheter device 110 and enhancing its performance.
  • Additionally, the temperature and flow rate of a coolant liquid may be specifically controlled to maintain the temperature of ultrasound transmission member 140 at a desired temperature within its optimal working range. In particular, in embodiments of the invention where ultrasound transmission member 140 is formed of a metal alloy which exhibits optimal physical properties (e.g. super elasticity) within a specific range of temperatures, the temperature and flow rate of coolant liquid infused through fluid inlet port 117 may be specifically controlled to maintain the temperature of ultrasound transmission member 140 within a range of temperatures at which it demonstrates its most desirable physical properties. For example, in embodiments of the invention where ultrasound transmission member 140 is formed of a shape memory alloy which exhibits super-elasticity when in its martensite state, but which loses super-elasticity as it transitions to an austenite state, it will be desirable to adjust the temperature and flow rate of the coolant liquid infused through fluid inlet port 117 to maintain the shape memory alloy of ultrasound transmission member 140 within a temperature range at which the alloy will remain in its martensite state and will not transition to an austenite state. The temperature at which such shape memory alloys transition from a martensite state to an austenite state is known as the “martensite transition temperature” of the material. Thus, in these embodiments, the fluid infused through port 117 will be at such temperature, and will be infused at such rate, as to maintain the shape memory alloy of ultrasound transmission member 140 below its martensite transition temperature.
  • As mentioned above, in one embodiment, a super-saturated fluid may be used. Use of such fluids may enhance cavitation of an occlusion, help prevent unwanted tissue damage and/or the like. Such fluids are described, for example, in U.S. Pat. Nos. 6,676,900, 6,622,542, 6,613,280, 6,607,698, 6,605,217, 6,602,468, 6,602,467, 6,596,235, 6,582,387, 6,576,807, 6,558,502, 6,555,059, 6,533,766, 6,454,997, 6,387,324, 6,346,192, 6,315,754, 6,248,087, 6,235,007, 6,180,059, 6,142,971, 6,123,698, 6,030,357, 5,976,119, 5,957,889, 5,893,838 and 5,797,876, which are hereby incorporated by reference. In another embodiment, a mixture of contrast dye and saline may be used to achieve the same or similar results.
  • With reference now to FIG. 4, one embodiment of an ultrasound catheter device 210 includes the features described immediately above and also includes a heat absorbing member 160 disposed within housing 112. Heat absorbing member 160 may have any suitable shape and size and may, in various embodiments, be disposed in any of a number of different locations within housing 112. Typically, heat absorbing member 160 is made of a heat absorbing material, such as but not limited to a metalized elastomer, such as a rubber material combined with a metallic powder such as aluminum powder. Of course, any other suitable heat sink or heat absorption material may be used, in alternative embodiments. In the embodiment shown, heat absorbing member 160 is generally cylindrical in shape and is disposed around vibration absorption members 150, so that it absorbs heat from ultrasound transmission member 140 and vibration absorbers 150.
  • Referring to FIG. 5, in an alternative embodiment an ultrasound catheter device 310 may include multiple heat absorption members 170, such as cylindrical members disposed around ultrasound transmission member 140 and in between multiple vibration absorption members 150. As is evident from FIGS. 4 and 5, any of a number of configurations of heat absorption members 160, 170 may be disposed within housing 112.
  • FIG. 6 demonstrates another embodiment of an ultrasound catheter device 410, which may include any of the features described above. In this embodiment, a fluid inlet port 217 is located farther proximally on housing 112 than in the earlier-described embodiments. Fluid inlet port 217 is in fluid communication with inner cavity 144 of housing 112, so that fluid (solid-tipped arrows) introduced into fluid inlet port 217 enters inner cavity 144 and contacts vibration absorption members 150 before entering the lumen of catheter body 127 via one or more proximal apertures 220. Fluid passing along and contacting vibration absorption members 150 will help dissipate heat from the members 150. As mentioned above, such fluids may be refrigerated/cooled, lubricious, oxygen supersaturated or the like. Lubricious and oxygen supersaturated fluids, in various embodiments, may be either cooled/refrigerated or at room temperature.
  • Referring to FIG. 7, another embodiment of an ultrasound catheter device 510 includes all the features just described, but fluid inlet port 317 is located farther proximally on housing 112. In this embodiment, fluid (solid-tipped arrows) entering fluid inlet port 317 contacts a proximal portion of ultrasound transmission member 140, proceeds distally to contact vibration absorption members 150, and then proceeds through apertures 220 into the lumen of catheter body 127. Thus, the fluid provides extra heat dissipation to the proximal portion of ultrasound transmission member 140 with which it comes in contact.
  • As mentioned above, in some embodiments irrigation/cooling fluid passes through a lumen of catheter body 127 and out one or more apertures in distal head 26 or elsewhere on the catheter device. In an alternative embodiment, and with reference now to FIG. 8, an ultrasound catheter device 610 may include a guidewire tube 424 that forms a guidewire lumen 426 and that includes one or more guidewire tube apertures 430 for allowing passage of fluid. Generally, a guidewire 420 may be passed through guidewire lumen 426 and out a distal aperture 422 of guidewire tube 424, located in distal head 26. Fluid (solid-tipped arrows) that is passed through a catheter body lumen 428 may flow into apertures 430 and out distal aperture 422. The fluid would thus contact ultrasound transmission member 140 during a portion of its journey through catheter body lumen 428, thus dissipating heat and/or lubricating, and would then pass out of catheter device 610 via guidewire tube 424. This configuration may be advantageous in that irrigation fluid may provide an additional lubrication inside guidewire lumen 426 to improve guidewire movement.
  • In one embodiment, housing 112 may include a material that changes color when its temperature increases or decreases, thus providing an indication of the temperature of the proximal portion of the catheter device. In one embodiment, for example, a thermochromic material, such as Colorcomp® Thermochromics (provided by LNP Engineering Plastics, Inc.) may be used. Other color-change materials may be used in alternative embodiments. In various embodiments, the color of such material may change at any suitable temperatures. In one embodiment, for example, the thermochromic pigment changes from a first color to a second color when the temperature of housing 112 reaches approximately 45° Celsius and changes from the second color to the first color when the temperature of housing 112 drops below approximately 45° Celsius.
  • Although the invention has been described above with specific reference to various embodiments and examples, it should be understood that various additions, modifications, deletions and alterations may be made to such embodiments without departing from the spirit or scope of the invention. Accordingly, it is intended that all reasonably foreseeable additions, deletions, alterations and modifications be included within the scope of the invention as defined in the following claims.

Claims (37)

1.-40. (canceled)
41. An ultrasound catheter system for disrupting occlusions in blood vessels, the system comprising:
an ultrasound catheter device, comprising:
an elongate flexible catheter body having a proximal end, a distal end and at least one lumen;
an ultrasound transmission member extending longitudinally through the lumen of the catheter body and having a proximal end and a distal end;
a distal head coupled with the distal end of the ultrasound transmission member and disposed adjacent the distal end of the catheter body;
a sonic connector coupled with the proximal end of the ultrasound transmission member for coupling the ultrasound transmission member with an ultrasound transducer device; and
a proximal housing coupled with the proximal end of the catheter body and housing the sonic connector and a proximal portion of the ultrasound transmission wire, wherein the housing includes at least one fluid inlet for allowing passage of one or more heat dissipating fluids into an inner cavity of the housing;
an ultrasound generator removably coupled with the ultrasound catheter device; and
a fluid cooling device removably coupled with the ultrasound catheter device for cooling the heat dissipating fluid(s).
42. A system as in claim 41, wherein one or more portions of the housing are constructed of a heat conductive material.
43. A system as in claim 42, wherein the heat conductive material is selected from the group consisting of metal, polymer, glass, rubber and combinations thereof.
44. A system as in claim 42, wherein the housing further comprises multiple surface features to increase a surface area of the housing.
45. A system as in claim 44, wherein the surface features are selected from the group consisting of grooves, notches, waves and dips.
46. A system as in claim 41, further comprising at least one conductive material disposed within the housing, at least partially encircling the ultrasound transmission member, to conduct heat away from the ultrasound transmission member.
47. A system as in claim 46, wherein the conductive material is disposed adjacent one or more vibration absorption members surrounding the ultrasound transmission member.
48. A system as in claim 47, wherein the at least one conductive material comprises multiple separate conductive members disposed between multiple vibration absorption members and at least partially encircling the ultrasound transmission member.
49. A system as in claim 46, wherein the conductive material is arranged over one or more vibration absorption members surrounding the ultrasound transmission member.
50. A system as in claim 41, wherein the inner cavity of the housing is in fluid communication with the lumen of the catheter body, such that fluid introduced into the inner cavity passes through and out a distal end of the catheter body lumen.
51. A system as in claim 41, wherein the inlet is disposed along the housing such that the heat dissipating fluid(s) passing through the inlet contact a proximal portion of the ultrasound transmission member.
52. A system as in claim 41, wherein the inlet is disposed along the housing such that the heat dissipating fluid(s) passing through the inlet contact at least one vibration absorption member disposed over the ultrasound transmission member.
53. A system as in claim 41, wherein the inlet is disposed along the housing such that the heat dissipating fluid(s) passing through the inlet contact the sonic connector and a portion of the ultrasound transmission member.
54. (canceled)
55. (canceled)
56. A system as in claim 41, wherein at least a portion of the proximal housing comprises a material adapted to change color when the temperature of the housing changes.
57. A system as in claim 56, wherein the material comprises a thermochromic pigment.
58. A system as in claim 57, wherein the thermochromic pigment changes from a first color to a second color when the temperature of the housing reaches approximately 45° Celsius and changes from the second color to the first color when the temperature of the housing drops below approximately 45° Celsius.
59. A method for disrupting an occlusion in a blood vessel, the method comprising:
positioning an ultrasound catheter in the blood vessel such that a distal end of the catheter is adjacent the occlusion;
transmitting ultrasound energy to an ultrasound transmission member of the ultrasound catheter to disrupt the occlusion into multiple occlusion fragments; and
passing a cooled irrigation fluid through the ultrasound catheter to dissipate heat away from the ultrasound transmission member.
60. A method as in claim 59, wherein the cooled fluid has a temperature between 1° C. and 22° C.
61. A method as in claim 59, wherein the cooled fluid is selected from the group consisting of saline, thrombolytic agents, antiplatelet drugs, lysing agents and anticoagulants.
62. A method as in claim 59, further comprising cooling the irrigation fluid to a desired temperature, using a refrigeration device coupled with the ultrasound catheter.
63. A method as in claim 59, wherein the cooled fluid is passed continuously through the ultrasound catheter during an occlusion disruption procedure.
64. A method as in claim 59, wherein the cooled fluid is passed through the ultrasound catheter while the catheter is activated and fluid passage is automatically stopped when the ultrasound catheter is deactivated.
65. A method for disrupting an occlusion in a blood vessel, the method comprising:
positioning an ultrasound catheter in the blood vessel such that a distal end of the catheter is adjacent the occlusion;
transmitting ultrasound energy to an ultrasound transmission member of the ultrasound catheter to disrupt the occlusion into multiple occlusion fragments; and
passing an oxygen supersaturated irrigation fluid through the ultrasound catheter to dissipate heat away from the ultrasound transmission member.
66. A method as in claim 65, wherein the oxygen supersaturated irrigation fluid comprises oxygen supersaturated saline solution.
67. A method as in claim 65, wherein the oxygen supersaturated irrigation fluid comprises saline solution combined with a radiopaque contrast material.
68. A method as in claim 65, wherein the oxygen supersaturated irrigation fluid has a temperature approximately the same as a room temperature.
69. A method as in claim 65, wherein the oxygen supersaturated irrigation fluid has a temperature between 1° C. and 22° C.
70. A method for disrupting an occlusion in a blood vessel, the method comprising:
positioning an ultrasound catheter in the blood vessel such that a distal end of the catheter is adjacent the occlusion;
transmitting ultrasound energy to an ultrasound transmission member of the ultrasound catheter to disrupt the occlusion into multiple occlusion fragments; and
passing a lubricious irrigation fluid through the ultrasound catheter to dissipate heat away from the ultrasound transmission member and reduce friction between the ultrasound transmission member and an ultrasound catheter body.
71. A method as in claim 70, wherein the lubricious irrigation fluid comprises an emulsion.
72. A method as in claim 71, wherein the emulsion comprises olive oil, egg yolk, phospholipids, glycerin, sodium deoxycholate, L-histidine, disodium CDTA, sodium hydroxide and water.
73. A method as in claim 71, wherein the emulsion has a pH of between 8.0 and 9.0.
74. A method as in claim 70, wherein the lubricious irrigation fluid has a temperature approximately the same as a room temperature.
75. A method as in claim 70, wherein the lubricious irrigation fluid has a temperature between 1° C. and 22° C.
76. A system as in claim 52, wherein the inlet is disposed along the housing such that the heat dissipating fluid(s) passing through the inlet contact the sonic connector and a portion of the ultrasound transmission member.
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US14/090,926 US10004520B2 (en) 2004-08-26 2013-11-26 Ultrasound catheter devices and methods
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Cited By (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012052924A1 (en) 2010-10-18 2012-04-26 CardioSonic Ltd. Separation device for ultrasound element
WO2012052921A1 (en) 2010-10-18 2012-04-26 CardioSonic Ltd. Ultrasound emission element
US20130226041A1 (en) * 2011-06-20 2013-08-29 Olympus Medical Systems Corp. Ultrasonic treatment device and probe unit
US8690818B2 (en) 1997-05-01 2014-04-08 Ekos Corporation Ultrasound catheter for providing a therapeutic effect to a vessel of a body
US8696612B2 (en) 2001-12-03 2014-04-15 Ekos Corporation Catheter with multiple ultrasound radiating members
US8740835B2 (en) 2010-02-17 2014-06-03 Ekos Corporation Treatment of vascular occlusions using ultrasonic energy and microbubbles
CN103860265A (en) * 2012-12-11 2014-06-18 韦伯斯特生物官能(以色列)有限公司 Lasso catheter with guide wire
US8764700B2 (en) 1998-06-29 2014-07-01 Ekos Corporation Sheath for use with an ultrasound element
US8852166B1 (en) 2002-04-01 2014-10-07 Ekos Corporation Ultrasonic catheter power control
WO2014124186A3 (en) * 2013-02-07 2015-01-08 Rocomp Global, Llc Electromagnetic radiation targeting devices, assemblies, systems and methods
US9028417B2 (en) 2010-10-18 2015-05-12 CardioSonic Ltd. Ultrasound emission element
US9044568B2 (en) 2007-06-22 2015-06-02 Ekos Corporation Method and apparatus for treatment of intracranial hemorrhages
US9107590B2 (en) 2004-01-29 2015-08-18 Ekos Corporation Method and apparatus for detecting vascular conditions with a catheter
US20160022289A1 (en) * 2014-07-28 2016-01-28 Shaw P. Wan Suction evacuation device
US9566456B2 (en) 2010-10-18 2017-02-14 CardioSonic Ltd. Ultrasound transceiver and cooling thereof
US9579494B2 (en) 2013-03-14 2017-02-28 Ekos Corporation Method and apparatus for drug delivery to a target site
US9849273B2 (en) 2009-07-03 2017-12-26 Ekos Corporation Power parameters for ultrasonic catheter
US20180206866A1 (en) * 2014-07-28 2018-07-26 Shaw P. Wan Suction evacuation device
US10092742B2 (en) 2014-09-22 2018-10-09 Ekos Corporation Catheter system
US10182833B2 (en) 2007-01-08 2019-01-22 Ekos Corporation Power parameters for ultrasonic catheter
US10188410B2 (en) 2007-01-08 2019-01-29 Ekos Corporation Power parameters for ultrasonic catheter
US10232196B2 (en) 2006-04-24 2019-03-19 Ekos Corporation Ultrasound therapy system
US10357304B2 (en) 2012-04-18 2019-07-23 CardioSonic Ltd. Tissue treatment
US10656025B2 (en) 2015-06-10 2020-05-19 Ekos Corporation Ultrasound catheter
US10888657B2 (en) 2010-08-27 2021-01-12 Ekos Corporation Method and apparatus for treatment of intracranial hemorrhages
US20210015509A1 (en) * 2017-01-12 2021-01-21 Shaw P. Wan Suction evacuation device
US20210022759A1 (en) * 2017-01-12 2021-01-28 Shaw P. Wan Suction evacuation device
US10933259B2 (en) 2013-05-23 2021-03-02 CardioSonic Ltd. Devices and methods for renal denervation and assessment thereof
US10967160B2 (en) 2010-10-18 2021-04-06 CardioSonic Ltd. Tissue treatment
US11318331B2 (en) 2017-03-20 2022-05-03 Sonivie Ltd. Pulmonary hypertension treatment
US11357447B2 (en) 2012-05-31 2022-06-14 Sonivie Ltd. Method and/or apparatus for measuring renal denervation effectiveness
US11458290B2 (en) 2011-05-11 2022-10-04 Ekos Corporation Ultrasound system

Families Citing this family (118)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9586023B2 (en) 1998-02-06 2017-03-07 Boston Scientific Limited Direct stream hydrodynamic catheter system
US8506519B2 (en) 1999-02-16 2013-08-13 Flowcardia, Inc. Pre-shaped therapeutic catheter
US6855123B2 (en) 2002-08-02 2005-02-15 Flow Cardia, Inc. Therapeutic ultrasound system
US8241274B2 (en) 2000-01-19 2012-08-14 Medtronic, Inc. Method for guiding a medical device
US8150519B2 (en) 2002-04-08 2012-04-03 Ardian, Inc. Methods and apparatus for bilateral renal neuromodulation
US7617005B2 (en) 2002-04-08 2009-11-10 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
US9955994B2 (en) 2002-08-02 2018-05-01 Flowcardia, Inc. Ultrasound catheter having protective feature against breakage
US8133236B2 (en) 2006-11-07 2012-03-13 Flowcardia, Inc. Ultrasound catheter having protective feature against breakage
US7335180B2 (en) 2003-11-24 2008-02-26 Flowcardia, Inc. Steerable ultrasound catheter
US6942677B2 (en) 2003-02-26 2005-09-13 Flowcardia, Inc. Ultrasound catheter apparatus
US7220233B2 (en) 2003-04-08 2007-05-22 Flowcardia, Inc. Ultrasound catheter devices and methods
US20050025646A1 (en) * 2003-07-30 2005-02-03 Vance Products Inc. D/B/A Cook Urological Incorporated Foot pedal medical irrigation system
JP2007504910A (en) 2003-09-12 2007-03-08 ミノウ・メディカル・エルエルシイ Selectable biased reshaping and / or excision of atherosclerotic material
US7758510B2 (en) 2003-09-19 2010-07-20 Flowcardia, Inc. Connector for securing ultrasound catheter to transducer
US7540852B2 (en) * 2004-08-26 2009-06-02 Flowcardia, Inc. Ultrasound catheter devices and methods
US8396548B2 (en) 2008-11-14 2013-03-12 Vessix Vascular, Inc. Selective drug delivery in a lumen
US9713730B2 (en) 2004-09-10 2017-07-25 Boston Scientific Scimed, Inc. Apparatus and method for treatment of in-stent restenosis
US8221343B2 (en) 2005-01-20 2012-07-17 Flowcardia, Inc. Vibrational catheter devices and methods for making same
US9282984B2 (en) 2006-04-05 2016-03-15 Flowcardia, Inc. Therapeutic ultrasound system
US8019435B2 (en) 2006-05-02 2011-09-13 Boston Scientific Scimed, Inc. Control of arterial smooth muscle tone
US20080039746A1 (en) 2006-05-25 2008-02-14 Medtronic, Inc. Methods of using high intensity focused ultrasound to form an ablated tissue area containing a plurality of lesions
EP2954868A1 (en) 2006-10-18 2015-12-16 Vessix Vascular, Inc. Tuned rf energy and electrical tissue characterization for selective treatment of target tissues
AU2007310991B2 (en) 2006-10-18 2013-06-20 Boston Scientific Scimed, Inc. System for inducing desirable temperature effects on body tissue
WO2008049082A2 (en) 2006-10-18 2008-04-24 Minnow Medical, Inc. Inducing desirable temperature effects on body tissue
US8246643B2 (en) 2006-11-07 2012-08-21 Flowcardia, Inc. Ultrasound catheter having improved distal end
US8974418B2 (en) * 2007-06-12 2015-03-10 Boston Scientific Limited Forwardly directed fluid jet crossing catheter
WO2009079539A1 (en) 2007-12-17 2009-06-25 Medrad, Inc. Rheolytic thrombectomy catheter with self-inflation distal balloon
US8439878B2 (en) 2007-12-26 2013-05-14 Medrad, Inc. Rheolytic thrombectomy catheter with self-inflating proximal balloon with drug infusion capabilities
US8647294B2 (en) 2008-03-20 2014-02-11 Medrad, Inc. Direct stream hydrodynamic catheter system
CN102271603A (en) 2008-11-17 2011-12-07 明诺医学股份有限公司 Selective accumulation of energy with or without knowledge of tissue topography
ITTR20080006A1 (en) * 2008-12-17 2010-06-18 Med Elettronica Srl TRANSDUCER FOR LOCALIZED TREATMENTS BY MECHANICAL ULTRASOUND STRENGTH WITH COOLING SYSTEM WITH INTEGRATED SINK
US8226566B2 (en) 2009-06-12 2012-07-24 Flowcardia, Inc. Device and method for vascular re-entry
EP2555699B1 (en) 2010-04-09 2019-04-03 Vessix Vascular, Inc. Power generating and control apparatus for the treatment of tissue
US9192790B2 (en) 2010-04-14 2015-11-24 Boston Scientific Scimed, Inc. Focused ultrasonic renal denervation
US8473067B2 (en) 2010-06-11 2013-06-25 Boston Scientific Scimed, Inc. Renal denervation and stimulation employing wireless vascular energy transfer arrangement
US9358365B2 (en) 2010-07-30 2016-06-07 Boston Scientific Scimed, Inc. Precision electrode movement control for renal nerve ablation
US9408661B2 (en) 2010-07-30 2016-08-09 Patrick A. Haverkost RF electrodes on multiple flexible wires for renal nerve ablation
US9155589B2 (en) 2010-07-30 2015-10-13 Boston Scientific Scimed, Inc. Sequential activation RF electrode set for renal nerve ablation
US9084609B2 (en) 2010-07-30 2015-07-21 Boston Scientific Scime, Inc. Spiral balloon catheter for renal nerve ablation
US9463062B2 (en) 2010-07-30 2016-10-11 Boston Scientific Scimed, Inc. Cooled conductive balloon RF catheter for renal nerve ablation
US8974451B2 (en) 2010-10-25 2015-03-10 Boston Scientific Scimed, Inc. Renal nerve ablation using conductive fluid jet and RF energy
US9220558B2 (en) 2010-10-27 2015-12-29 Boston Scientific Scimed, Inc. RF renal denervation catheter with multiple independent electrodes
US9028485B2 (en) 2010-11-15 2015-05-12 Boston Scientific Scimed, Inc. Self-expanding cooling electrode for renal nerve ablation
US9089350B2 (en) 2010-11-16 2015-07-28 Boston Scientific Scimed, Inc. Renal denervation catheter with RF electrode and integral contrast dye injection arrangement
US9668811B2 (en) 2010-11-16 2017-06-06 Boston Scientific Scimed, Inc. Minimally invasive access for renal nerve ablation
US9326751B2 (en) 2010-11-17 2016-05-03 Boston Scientific Scimed, Inc. Catheter guidance of external energy for renal denervation
US9060761B2 (en) 2010-11-18 2015-06-23 Boston Scientific Scime, Inc. Catheter-focused magnetic field induced renal nerve ablation
US9023034B2 (en) 2010-11-22 2015-05-05 Boston Scientific Scimed, Inc. Renal ablation electrode with force-activatable conduction apparatus
US9192435B2 (en) 2010-11-22 2015-11-24 Boston Scientific Scimed, Inc. Renal denervation catheter with cooled RF electrode
US20120157993A1 (en) 2010-12-15 2012-06-21 Jenson Mark L Bipolar Off-Wall Electrode Device for Renal Nerve Ablation
US9220561B2 (en) 2011-01-19 2015-12-29 Boston Scientific Scimed, Inc. Guide-compatible large-electrode catheter for renal nerve ablation with reduced arterial injury
AU2012283908B2 (en) 2011-07-20 2017-02-16 Boston Scientific Scimed, Inc. Percutaneous devices and methods to visualize, target and ablate nerves
AU2012287189B2 (en) 2011-07-22 2016-10-06 Boston Scientific Scimed, Inc. Nerve modulation system with a nerve modulation element positionable in a helical guide
US8974478B2 (en) 2011-09-20 2015-03-10 Covidien Lp Ultrasonic surgical system having a fluid cooled blade and related cooling methods therefor
US9186210B2 (en) 2011-10-10 2015-11-17 Boston Scientific Scimed, Inc. Medical devices including ablation electrodes
WO2013055815A1 (en) 2011-10-11 2013-04-18 Boston Scientific Scimed, Inc. Off -wall electrode device for nerve modulation
US9420955B2 (en) 2011-10-11 2016-08-23 Boston Scientific Scimed, Inc. Intravascular temperature monitoring system and method
US9364284B2 (en) 2011-10-12 2016-06-14 Boston Scientific Scimed, Inc. Method of making an off-wall spacer cage
EP2768568B1 (en) 2011-10-18 2020-05-06 Boston Scientific Scimed, Inc. Integrated crossing balloon catheter
EP2768563B1 (en) 2011-10-18 2016-11-09 Boston Scientific Scimed, Inc. Deflectable medical devices
CN104023662B (en) 2011-11-08 2018-02-09 波士顿科学西美德公司 Hole portion renal nerve melts
US9119600B2 (en) 2011-11-15 2015-09-01 Boston Scientific Scimed, Inc. Device and methods for renal nerve modulation monitoring
US9119632B2 (en) 2011-11-21 2015-09-01 Boston Scientific Scimed, Inc. Deflectable renal nerve ablation catheter
US9265969B2 (en) 2011-12-21 2016-02-23 Cardiac Pacemakers, Inc. Methods for modulating cell function
EP3138521B1 (en) 2011-12-23 2019-05-29 Vessix Vascular, Inc. Apparatuses for remodeling tissue of or adjacent to a body passage
US9433760B2 (en) 2011-12-28 2016-09-06 Boston Scientific Scimed, Inc. Device and methods for nerve modulation using a novel ablation catheter with polymeric ablative elements
US9050106B2 (en) 2011-12-29 2015-06-09 Boston Scientific Scimed, Inc. Off-wall electrode device and methods for nerve modulation
WO2013109269A1 (en) 2012-01-18 2013-07-25 Bard Peripheral Vascular, Inc. Vascular re-entry device
WO2013169927A1 (en) 2012-05-08 2013-11-14 Boston Scientific Scimed, Inc. Renal nerve modulation devices
JP6293145B2 (en) 2012-08-02 2018-03-14 バード・ペリフェラル・バスキュラー・インコーポレーテッド Ultrasound catheter system
WO2014032016A1 (en) 2012-08-24 2014-02-27 Boston Scientific Scimed, Inc. Intravascular catheter with a balloon comprising separate microporous regions
CN104780859B (en) 2012-09-17 2017-07-25 波士顿科学西美德公司 Self-positioning electrode system and method for renal regulation
WO2014047454A2 (en) 2012-09-21 2014-03-27 Boston Scientific Scimed, Inc. Self-cooling ultrasound ablation catheter
WO2014047411A1 (en) 2012-09-21 2014-03-27 Boston Scientific Scimed, Inc. System for nerve modulation and innocuous thermal gradient nerve block
US10835305B2 (en) 2012-10-10 2020-11-17 Boston Scientific Scimed, Inc. Renal nerve modulation devices and methods
EP3434311B1 (en) 2012-12-28 2021-01-27 Bard Peripheral Vascular, Inc. Drug delivery via mechanical vibration balloon
WO2014163987A1 (en) 2013-03-11 2014-10-09 Boston Scientific Scimed, Inc. Medical devices for modulating nerves
US9693821B2 (en) 2013-03-11 2017-07-04 Boston Scientific Scimed, Inc. Medical devices for modulating nerves
US9808311B2 (en) 2013-03-13 2017-11-07 Boston Scientific Scimed, Inc. Deflectable medical devices
US10265122B2 (en) 2013-03-15 2019-04-23 Boston Scientific Scimed, Inc. Nerve ablation devices and related methods of use
JP6220044B2 (en) 2013-03-15 2017-10-25 ボストン サイエンティフィック サイムド,インコーポレイテッドBoston Scientific Scimed,Inc. Medical device for renal nerve ablation
AU2014237950B2 (en) 2013-03-15 2017-04-13 Boston Scientific Scimed, Inc. Control unit for use with electrode pads and a method for estimating an electrical leakage
WO2014205399A1 (en) 2013-06-21 2014-12-24 Boston Scientific Scimed, Inc. Medical devices for renal nerve ablation having rotatable shafts
WO2014205388A1 (en) 2013-06-21 2014-12-24 Boston Scientific Scimed, Inc. Renal denervation balloon catheter with ride along electrode support
US9707036B2 (en) 2013-06-25 2017-07-18 Boston Scientific Scimed, Inc. Devices and methods for nerve modulation using localized indifferent electrodes
EP3016605B1 (en) 2013-07-01 2019-06-05 Boston Scientific Scimed, Inc. Medical devices for renal nerve ablation
CN105377170A (en) 2013-07-11 2016-03-02 波士顿科学国际有限公司 Medical device with stretchable electrode assemblies
US10660698B2 (en) 2013-07-11 2020-05-26 Boston Scientific Scimed, Inc. Devices and methods for nerve modulation
CN105682594B (en) 2013-07-19 2018-06-22 波士顿科学国际有限公司 Helical bipolar electrodes renal denervation dominates air bag
WO2015013301A1 (en) 2013-07-22 2015-01-29 Boston Scientific Scimed, Inc. Renal nerve ablation catheter having twist balloon
WO2015013205A1 (en) 2013-07-22 2015-01-29 Boston Scientific Scimed, Inc. Medical devices for renal nerve ablation
JP6049569B2 (en) * 2013-08-22 2016-12-21 オリンパス株式会社 Surgical system and trocar
EP4049605A1 (en) 2013-08-22 2022-08-31 Boston Scientific Scimed Inc. Flexible circuit having improved adhesion to a renal nerve modulation balloon
CN105555218B (en) 2013-09-04 2019-01-15 波士顿科学国际有限公司 With radio frequency (RF) foley's tube rinsed with cooling capacity
CN105530885B (en) 2013-09-13 2020-09-22 波士顿科学国际有限公司 Ablation balloon with vapor deposited covering
US11246654B2 (en) 2013-10-14 2022-02-15 Boston Scientific Scimed, Inc. Flexible renal nerve ablation devices and related methods of use and manufacture
US9687166B2 (en) 2013-10-14 2017-06-27 Boston Scientific Scimed, Inc. High resolution cardiac mapping electrode array catheter
CN105636537B (en) 2013-10-15 2018-08-17 波士顿科学国际有限公司 Medical instrument sacculus
US9770606B2 (en) 2013-10-15 2017-09-26 Boston Scientific Scimed, Inc. Ultrasound ablation catheter with cooling infusion and centering basket
EP3057521B1 (en) 2013-10-18 2020-03-25 Boston Scientific Scimed, Inc. Balloon catheters with flexible conducting wires
US10271898B2 (en) 2013-10-25 2019-04-30 Boston Scientific Scimed, Inc. Embedded thermocouple in denervation flex circuit
JP2017502715A (en) 2013-11-18 2017-01-26 コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. Thrombus dispersion method and apparatus
CN105899157B (en) 2014-01-06 2019-08-09 波士顿科学国际有限公司 Tear-proof flexible circuit assembly
CN106572881B (en) 2014-02-04 2019-07-26 波士顿科学国际有限公司 Substitution of the heat sensor on bipolar electrode is placed
US11000679B2 (en) 2014-02-04 2021-05-11 Boston Scientific Scimed, Inc. Balloon protection and rewrapping devices and related methods of use
AU2016206743B2 (en) * 2015-01-15 2020-02-27 Covidien Lp Device for accommodating surgical tool prior to and during medical procedures
WO2017214573A1 (en) 2016-06-09 2017-12-14 C. R. Bard, Inc. Systems and methods for correcting and preventing occlusion in a catheter
US20180140321A1 (en) 2016-11-23 2018-05-24 C. R. Bard, Inc. Catheter With Retractable Sheath And Methods Thereof
KR101851348B1 (en) * 2016-11-30 2018-04-23 주식회사 하이투모로 Hand piece of ultrasonic scalpel for surgical operation
US11596726B2 (en) 2016-12-17 2023-03-07 C.R. Bard, Inc. Ultrasound devices for removing clots from catheters and related methods
US10758256B2 (en) 2016-12-22 2020-09-01 C. R. Bard, Inc. Ultrasonic endovascular catheter
US10582983B2 (en) 2017-02-06 2020-03-10 C. R. Bard, Inc. Ultrasonic endovascular catheter with a controllable sheath
US10470748B2 (en) 2017-04-03 2019-11-12 C. R. Bard, Inc. Ultrasonic endovascular catheter with expandable portion
EP4215133A1 (en) * 2017-11-10 2023-07-26 C. R. Bard, Inc. Heat sinks for catheters and systems thereof
JP7339388B2 (en) 2017-11-10 2023-09-05 シー・アール・バード・インコーポレーテッド Catheter heat sink and system and method
US10792054B1 (en) * 2019-07-11 2020-10-06 Eduardo Lorenzo Catheter for thromboembolic disease with mechanic waves, injection and ejection
US20230172624A1 (en) * 2020-04-22 2023-06-08 Bard Peripheral Vascular, Inc. Ultrasonic catheter, device, and system
US20230190087A1 (en) * 2021-12-22 2023-06-22 Covidien Lp Surgical systems and methods for component cooling while warming fluid to be introduced during a surgical procedure

Citations (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3433266A (en) * 1967-03-22 1969-03-18 Moog Inc Positive centering servovalve having movable spring backup
US3565062A (en) * 1968-06-13 1971-02-23 Ultrasonic Systems Ultrasonic method and apparatus for removing cholesterol and other deposits from blood vessels and the like
US3631848A (en) * 1968-09-04 1972-01-04 Us Catheter & Instr Corp Extensible catheter
US3719737A (en) * 1970-12-09 1973-03-06 Bard Inc C R Method of making a preformed curved epidural catheter
US4016882A (en) * 1975-03-05 1977-04-12 Cavitron Corporation Neurosonic aspirator and method
US4368410A (en) * 1980-10-14 1983-01-11 Dynawave Corporation Ultrasound therapy device
US4425115A (en) * 1977-12-19 1984-01-10 Wuchinich David G Ultrasonic resonant vibrator
US4565589A (en) * 1982-03-05 1986-01-21 Raychem Corporation Nickel/titanium/copper shape memory alloy
US4572184A (en) * 1983-10-28 1986-02-25 Blackstone Corporation Wave guide attachment means and methods
US4664112A (en) * 1985-08-12 1987-05-12 Intravascular Surgical Instruments, Inc. Catheter based surgical methods and apparatus therefor
US4665906A (en) * 1983-10-14 1987-05-19 Raychem Corporation Medical devices incorporating sim alloy elements
US4721117A (en) * 1986-04-25 1988-01-26 Advanced Cardiovascular Systems, Inc. Torsionally stabilized guide wire with outer jacket
US4808153A (en) * 1986-11-17 1989-02-28 Ultramed Corporation Device for removing plaque from arteries
US4811743A (en) * 1987-04-21 1989-03-14 Cordis Corporation Catheter guidewire
US4827911A (en) * 1986-04-02 1989-05-09 Cooper Lasersonics, Inc. Method and apparatus for ultrasonic surgical fragmentation and removal of tissue
US4920954A (en) * 1988-08-05 1990-05-01 Sonic Needle Corporation Ultrasonic device for applying cavitation forces
US4923462A (en) * 1987-03-17 1990-05-08 Cordis Corporation Catheter system having a small diameter rotatable drive member
US4924863A (en) * 1988-05-04 1990-05-15 Mmtc, Inc. Angioplastic method for removing plaque from a vas
US5000185A (en) * 1986-02-28 1991-03-19 Cardiovascular Imaging Systems, Inc. Method for intravascular two-dimensional ultrasonography and recanalization
US5015227A (en) * 1987-09-30 1991-05-14 Valleylab Inc. Apparatus for providing enhanced tissue fragmentation and/or hemostasis
US5091205A (en) * 1989-01-17 1992-02-25 Union Carbide Chemicals & Plastics Technology Corporation Hydrophilic lubricious coatings
US5100423A (en) * 1990-08-21 1992-03-31 Medical Engineering & Development Institute, Inc. Ablation catheter
US5109859A (en) * 1989-10-04 1992-05-05 Beth Israel Hospital Association Ultrasound guided laser angioplasty
US5114414A (en) * 1984-09-18 1992-05-19 Medtronic, Inc. Low profile steerable catheter
US5116350A (en) * 1987-03-17 1992-05-26 Cordis Corporation Catheter system having distal tip for opening obstructions
US5180363A (en) * 1989-04-27 1993-01-19 Sumitomo Bakelite Company Company Limited Operation device
US5183470A (en) * 1991-03-04 1993-02-02 International Medical, Inc. Laparoscopic cholangiogram catheter and method of using same
US5195955A (en) * 1989-11-14 1993-03-23 Don Michael T Anthony Device for removal of embolic debris
US5287858A (en) * 1992-09-23 1994-02-22 Pilot Cardiovascular Systems, Inc. Rotational atherectomy guidewire
US5290229A (en) * 1991-07-15 1994-03-01 Paskar Larry D Transformable catheter and method
US5304115A (en) * 1991-01-11 1994-04-19 Baxter International Inc. Ultrasonic angioplasty device incorporating improved transmission member and ablation probe
US5304131A (en) * 1991-07-15 1994-04-19 Paskar Larry D Catheter
US5312328A (en) * 1991-01-11 1994-05-17 Baxter International Inc. Ultra-sound catheter for removing obstructions from tubular anatomical structures such as blood vessels
US5378234A (en) * 1993-03-15 1995-01-03 Pilot Cardiovascular Systems, Inc. Coil polymer composite
US5380316A (en) * 1990-12-18 1995-01-10 Advanced Cardiovascular Systems, Inc. Method for intra-operative myocardial device revascularization
US5380274A (en) * 1991-01-11 1995-01-10 Baxter International Inc. Ultrasound transmission member having improved longitudinal transmission properties
US5382228A (en) * 1992-07-09 1995-01-17 Baxter International Inc. Method and device for connecting ultrasound transmission member (S) to an ultrasound generating device
US5383460A (en) * 1992-10-05 1995-01-24 Cardiovascular Imaging Systems, Inc. Method and apparatus for ultrasound imaging and atherectomy
US5389096A (en) * 1990-12-18 1995-02-14 Advanced Cardiovascular Systems System and method for percutaneous myocardial revascularization
US5397293A (en) * 1992-11-25 1995-03-14 Misonix, Inc. Ultrasonic device with sheath and transverse motion damping
US5405318A (en) * 1992-05-05 1995-04-11 Baxter International Inc. Ultra-sound catheter for removing obstructions from tubular anatomical structures such as blood vessels
US5409483A (en) * 1993-01-22 1995-04-25 Jeffrey H. Reese Direct visualization surgical probe
US5417672A (en) * 1993-10-04 1995-05-23 Baxter International Inc. Connector for coupling an ultrasound transducer to an ultrasound catheter
US5480379A (en) * 1991-05-22 1996-01-02 La Rosa; Antonio Ultrasonic dissector and detacher for atherosclerotic plaque and method of using same
US5484398A (en) * 1994-03-17 1996-01-16 Valleylab Inc. Methods of making and using ultrasonic handpiece
US5487757A (en) * 1993-07-20 1996-01-30 Medtronic Cardiorhythm Multicurve deflectable catheter
US5507738A (en) * 1994-08-05 1996-04-16 Microsonic Engineering Devices Company, Inc. Ultrasonic vascular surgical system
US5597882A (en) * 1991-11-15 1997-01-28 Wacker-Chemie Gmbh Tin compound-containing compositions as one of the two components of two component systems which crosslink at room temperature to give organopolysiloxane elastomers
US5607421A (en) * 1991-05-01 1997-03-04 The Trustees Of Columbia University In The City Of New York Myocardial revascularization through the endocardial surface using a laser
US5611807A (en) * 1993-02-05 1997-03-18 The Joe W. & Dorothy Dorsett Brown Foundation Ultrasonic angioplasty balloon catheter
US5618266A (en) * 1994-03-31 1997-04-08 Liprie; Samuel F. Catheter for maneuvering radioactive source wire to site of treatment
US5715825A (en) * 1988-03-21 1998-02-10 Boston Scientific Corporation Acoustic imaging catheter and the like
US5720724A (en) * 1988-02-29 1998-02-24 Scimed Life Systems, Inc. Intravascular catheter with distal guide wire lumen and transition member
US5728062A (en) * 1995-11-30 1998-03-17 Pharmasonics, Inc. Apparatus and methods for vibratory intraluminal therapy employing magnetostrictive transducers
US5738100A (en) * 1995-06-30 1998-04-14 Terumo Kabushiki Kaisha Ultrasonic imaging catheter
US5893838A (en) * 1997-08-15 1999-04-13 Therox, Inc. System and method for high pressure delivery of gas-supersaturated fluids
US5895397A (en) * 1990-05-21 1999-04-20 Cardiovascular Imaging Systems, Inc. Intravascular catheter having combined imaging abrasion head
US6022309A (en) * 1996-04-24 2000-02-08 The Regents Of The University Of California Opto-acoustic thrombolysis
US6029671A (en) * 1991-07-16 2000-02-29 Heartport, Inc. System and methods for performing endovascular procedures
US6051010A (en) * 1996-12-23 2000-04-18 Ethicon Endo-Surgery, Inc. Methods and devices for joining transmission components
US6179809B1 (en) * 1997-09-24 2001-01-30 Eclipse Surgical Technologies, Inc. Drug delivery catheter with tip alignment
US6180059B1 (en) * 1995-06-05 2001-01-30 Therox, Inc. Method for the preparation and delivery of gas-enriched fluids
US6190353B1 (en) * 1995-10-13 2001-02-20 Transvascular, Inc. Methods and apparatus for bypassing arterial obstructions and/or performing other transvascular procedures
US6206842B1 (en) * 1998-08-03 2001-03-27 Lily Chen Tu Ultrasonic operation device
US6210356B1 (en) * 1998-08-05 2001-04-03 Ekos Corporation Ultrasound assembly for use with a catheter
US6217543B1 (en) * 1990-07-17 2001-04-17 Aziz Yehia Anis Removal of tissue
US6346192B2 (en) * 1999-05-14 2002-02-12 Therox, Inc. Apparatus for high pressure fluid filtration
US6379378B1 (en) * 2000-03-03 2002-04-30 Innercool Therapies, Inc. Lumen design for catheter
US20030009153A1 (en) * 1998-07-29 2003-01-09 Pharmasonics, Inc. Ultrasonic enhancement of drug injection
US6508784B1 (en) * 2000-05-19 2003-01-21 Yan-Ho Shu Balloon catheter having adjustable centering capabilities and methods thereof
US6508781B1 (en) * 1999-12-30 2003-01-21 Advanced Cardiovascular Systems, Inc. Ultrasonic ablation catheter transmission wire connector assembly
US6511458B2 (en) * 1998-01-13 2003-01-28 Lumend, Inc. Vascular re-entry catheter
US20030036705A1 (en) * 1999-10-05 2003-02-20 Omnisonics Medical Technologies, Inc. Ultrasonic probe device having an impedance mismatch with rapid attachment and detachment means
US6524251B2 (en) * 1999-10-05 2003-02-25 Omnisonics Medical Technologies, Inc. Ultrasonic device for tissue ablation and sheath for use therewith
US6533766B1 (en) * 1998-07-24 2003-03-18 Therox, Inc. Coating medical device surfaces for delivering gas-supersaturated fluids
US6544215B1 (en) * 1998-10-02 2003-04-08 Scimed Life Systems, Inc. Steerable device for introducing diagnostic and therapeutic apparatus into the body
US6547754B1 (en) * 1993-05-19 2003-04-15 Bacchus Vascular, Inc. Thrombolysis device
US6551337B1 (en) * 1999-10-05 2003-04-22 Omnisonics Medical Technologies, Inc. Ultrasonic medical device operating in a transverse mode
US6554846B2 (en) * 2001-09-28 2003-04-29 Scimed Life Systems, Inc. Sonic burr
US6555059B1 (en) * 1999-09-30 2003-04-29 Therox, Inc. Method of forming gas-enriched fluid
US6676900B1 (en) * 1994-12-09 2004-01-13 Therox, Inc. Method for the preparation and delivery of gas-enriched fluids
US6682502B2 (en) * 1999-03-26 2004-01-27 Transon, Llc Apparatus for emergency treatment of patients experiencing a thrombotic vascular occlusion
US6685657B2 (en) * 1998-11-20 2004-02-03 Joie P. Jones Methods for selectively dissolving and removing materials using ultra-high frequency ultrasound
US6689086B1 (en) * 1994-10-27 2004-02-10 Advanced Cardiovascular Systems, Inc. Method of using a catheter for delivery of ultrasonic energy and medicament
US6695810B2 (en) * 1997-11-21 2004-02-24 Advanced Interventional Technologies, Inc. Endolumenal aortic isolation assembly and method
US6695782B2 (en) * 1999-10-05 2004-02-24 Omnisonics Medical Technologies, Inc. Ultrasonic probe device with rapid attachment and detachment means
US6695781B2 (en) * 1999-10-05 2004-02-24 Omnisonics Medical Technologies, Inc. Ultrasonic medical device for tissue remodeling
US6702750B2 (en) * 1986-04-15 2004-03-09 Cardiovascular Imaging Systems, Inc. Angioplasty apparatus facilitating rapid exchanges and methods
US6855123B2 (en) * 2002-08-02 2005-02-15 Flow Cardia, Inc. Therapeutic ultrasound system
US6866670B2 (en) * 1999-10-05 2005-03-15 Omnisonics Medical Technologies, Inc. Apparatus for removing plaque from blood vessels using ultrasonic energy
US7004173B2 (en) * 2000-12-05 2006-02-28 Lumend, Inc. Catheter system for vascular re-entry from a sub-intimal space
US20070037119A1 (en) * 2005-08-11 2007-02-15 Cook Incorporated System for breaking up thrombi and plaque in the vasculature
US7335180B2 (en) * 2003-11-24 2008-02-26 Flowcardia, Inc. Steerable ultrasound catheter

Family Cites Families (265)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3296620A (en) 1963-11-20 1967-01-03 Ellsworth N Rodda Convertible horn radiator-coupler for separable missile
GB1106957A (en) 1965-04-06 1968-03-20 Oleg Gavrilovich Balaev Instrument for crushing concretions in the urinary bladder
US3433226A (en) * 1965-07-21 1969-03-18 Aeroprojects Inc Vibratory catheterization apparatus and method of using
DE1596290B1 (en) 1966-04-23 1970-07-30 Varta Gmbh Closing valve for galvanic elements
FR1583261A (en) 1968-07-10 1969-10-24 Eni Elect Nijverheidsinstall
US3835690A (en) 1968-11-02 1974-09-17 Zueblin Ag Device for connecting metallic sleeves to finned reinforcing bars
US3612038A (en) 1969-02-03 1971-10-12 Becton Dickinson Co Preformable catheter package assembly and method of preforming
US3739460A (en) 1971-06-01 1973-06-19 Thomas & Betts Corp Method of joining concentric members
DE2219790C3 (en) * 1972-04-22 1974-11-07 R Pohlman Device for generating brittle fractures in hard stones
US3839841A (en) 1972-07-13 1974-10-08 K Amplatz Method for forming and sterilizing catheters
DE2242863A1 (en) 1972-08-31 1974-03-14 Karl Storz SURGICAL ELEMENT FOR CRUSHING STONES IN THE HUMAN BODY BY ULTRASOUND
DE2256127A1 (en) 1972-11-16 1974-05-22 Reimar Prof Dr Phil Pohlman DEVICE FOR CRUSHING HARNSTONE
DE2438648A1 (en) 1974-08-12 1976-02-26 Reimar Prof Dr Phil Pohlman Dispersal and removal of thromboses within blood vessels - using ultrasonic sound conducting cannulae bundle with central suction opening and transmission facility for infusion liquids
US4033331A (en) 1975-07-17 1977-07-05 Guss Stephen B Cardiac catheter and method of using same
CA1158289A (en) 1980-02-28 1983-12-06 Michiharu Okuno Circuit interrupter
US4337090A (en) * 1980-09-05 1982-06-29 Raychem Corporation Heat recoverable nickel/titanium alloy with improved stability and machinability
US4417578A (en) 1981-03-20 1983-11-29 Surgical Design Ultrasonic transducer with energy shielding
GB2116046B (en) 1982-03-04 1985-05-22 Wolf Gmbh Richard Apparatus for disintegrating and removing calculi
JPS5991476A (en) 1982-11-17 1984-05-26 東京電力株式会社 Training sumilator
US4565787A (en) 1983-05-09 1986-01-21 The United States Of America As Represented By The Secretary Of The Army High performance liquid chromatography (HPLC) analysis of sulfur mustards and their decomposition by-products by derivatization
US4505767A (en) * 1983-10-14 1985-03-19 Raychem Corporation Nickel/titanium/vanadium shape memory alloy
JPS61272045A (en) 1985-05-29 1986-12-02 住友ベークライト株式会社 Ultrasonic operation apparatus
US4700705A (en) 1985-08-12 1987-10-20 Intravascular Surgical Instruments, Inc. Catheter based surgical methods and apparatus therefor
US4679558A (en) 1985-08-12 1987-07-14 Intravascular Surgical Instruments, Inc. Catheter based surgical methods and apparatus therefor
US4750902A (en) 1985-08-28 1988-06-14 Sonomed Technology, Inc. Endoscopic ultrasonic aspirators
FR2595860A1 (en) 1986-03-17 1987-09-18 Kodak Pathe COMPENSATION FILTER FOR RADIOGRAPHY
RU2050152C1 (en) 1986-11-27 1995-12-20 Сумимото Бейклайт Компани Лимитед Ultrasonic surgical apparatus
US4838853A (en) 1987-02-05 1989-06-13 Interventional Technologies Inc. Apparatus for trimming meniscus
US4936845A (en) 1987-03-17 1990-06-26 Cordis Corporation Catheter system having distal tip for opening obstructions
SE459711B (en) * 1987-03-20 1989-07-31 Swedemed Ab EQUIPMENT FOR USE IN SURGICAL INTERVENTIONS TO DISPOSE TISSUE
US4931047A (en) 1987-09-30 1990-06-05 Cavitron, Inc. Method and apparatus for providing enhanced tissue fragmentation and/or hemostasis
JPH0199547A (en) 1987-10-13 1989-04-18 Olympus Optical Co Ltd Ultrasonic treatment apparatus
US4854325A (en) 1987-11-09 1989-08-08 Stevens Robert C Reciprocating guidewire method
US4870953A (en) 1987-11-13 1989-10-03 Donmicheal T Anthony Intravascular ultrasonic catheter/probe and method for treating intravascular blockage
DE3738797A1 (en) 1987-11-14 1989-05-24 Rentrop Hubbert & Wagner LINEAR ADJUSTABLE FORCE TRANSMISSION ELEMENT WITH CONTINUOUS, INACCESSIVE SENSITIVITY BLOCKING
US5163421A (en) 1988-01-22 1992-11-17 Angiosonics, Inc. In vivo ultrasonic system with angioplasty and ultrasonic contrast imaging
CA1325458C (en) 1988-01-22 1993-12-21 Jonathan Bernstein Vivo ultrasonic system for angioplasty and ultrasonic contrast imaging
DE3821836A1 (en) 1988-06-29 1990-01-04 Fraunhofer Ges Forschung AERODYNAMIC WINDOW FOR A GAS LASER
JPH027150U (en) 1988-06-30 1990-01-17
DE8910040U1 (en) 1988-09-03 1989-12-14 Leybold Ag
JPH0271510A (en) 1988-09-07 1990-03-12 Oki Electric Ind Co Ltd Apparatus for semiconductor vapor growth
US4989583A (en) 1988-10-21 1991-02-05 Nestle S.A. Ultrasonic cutting tip assembly
US4978333A (en) 1988-12-20 1990-12-18 Valleylab, Inc. Resonator for surgical handpiece
US5318570A (en) 1989-01-31 1994-06-07 Advanced Osseous Technologies, Inc. Ultrasonic tool
US5255669A (en) 1989-04-12 1993-10-26 Olympus Optical Co., Ltd. Ultrasonic treatment apparatus
US4936281A (en) * 1989-04-13 1990-06-26 Everest Medical Corporation Ultrasonically enhanced RF ablation catheter
US5046503A (en) 1989-04-26 1991-09-10 Advanced Cardiovascular Systems, Inc. Angioplasty autoperfusion catheter flow measurement method and apparatus
JPH02286149A (en) 1989-04-27 1990-11-26 Sumitomo Bakelite Co Ltd Surgery operating device
DK0401158T3 (en) 1989-06-01 1996-06-10 Schneider Europ Ag Catheter device with a guidewire, and method of making such a guidewire
NL8901654A (en) 1989-06-29 1991-01-16 Cordis Europ METHOD FOR MANUFACTURING CATHETER, AND CATHETER MANUFACTURED WITH THIS METHOD
US5269793A (en) 1989-07-20 1993-12-14 Devices For Vascular Intervention, Inc. Guide wire systems for intravascular catheters
US5171216A (en) 1989-08-28 1992-12-15 Thermedics, Inc. Multi-lumen catheter coupling
FR2653040B1 (en) 1989-10-18 1994-05-13 Aerospatiale Ste Nationale Indle ULTRASONIC PERCUSSION DEVICE.
JPH0713691Y2 (en) 1989-11-07 1995-04-05 オリンパス光学工業株式会社 Ultrasonic therapy equipment
US5163433A (en) * 1989-11-01 1992-11-17 Olympus Optical Co., Ltd. Ultrasound type treatment apparatus
US5076276A (en) 1989-11-01 1991-12-31 Olympus Optical Co., Ltd. Ultrasound type treatment apparatus
US5026384A (en) 1989-11-07 1991-06-25 Interventional Technologies, Inc. Atherectomy systems and methods
US5344395A (en) 1989-11-13 1994-09-06 Scimed Life Systems, Inc. Apparatus for intravascular cavitation or delivery of low frequency mechanical energy
WO1991007917A2 (en) 1989-11-27 1991-06-13 Beat Krattiger Ultrasonic surgical instrument
US5221255A (en) 1990-01-10 1993-06-22 Mahurkar Sakharam D Reinforced multiple lumen catheter
IL93141A0 (en) * 1990-01-23 1990-11-05 Urcan Medical Ltd Ultrasonic recanalization system
DE4042435C3 (en) 1990-02-02 1998-12-10 Olympus Optical Co Ultrasound treatment device
US5391144A (en) 1990-02-02 1995-02-21 Olympus Optical Co., Ltd. Ultrasonic treatment apparatus
US5238004A (en) 1990-04-10 1993-08-24 Boston Scientific Corporation High elongation linear elastic guidewire
US5030357A (en) 1990-09-11 1991-07-09 Lowe Engineering Company Oil/grease recovery method and apparatus
US5053008A (en) 1990-11-21 1991-10-01 Sandeep Bajaj Intracardiac catheter
US5269291A (en) 1990-12-10 1993-12-14 Coraje, Inc. Miniature ultrasonic transducer for plaque ablation
US5341818A (en) 1992-12-22 1994-08-30 Advanced Cardiovascular Systems, Inc. Guidewire with superelastic distal portion
US5248296A (en) 1990-12-24 1993-09-28 Sonic Needle Corporation Ultrasonic device having wire sheath
US5447509A (en) 1991-01-11 1995-09-05 Baxter International Inc. Ultrasound catheter system having modulated output with feedback control
US5542917A (en) * 1991-01-11 1996-08-06 Baxter International, Inc. Ultrasound delivery catheters incorporating improved distal tip construction
US5916192A (en) * 1991-01-11 1999-06-29 Advanced Cardiovascular Systems, Inc. Ultrasonic angioplasty-atherectomy catheter and method of use
US5324255A (en) 1991-01-11 1994-06-28 Baxter International Inc. Angioplasty and ablative devices having onboard ultrasound components and devices and methods for utilizing ultrasound to treat or prevent vasopasm
US5267954A (en) * 1991-01-11 1993-12-07 Baxter International Inc. Ultra-sound catheter for removing obstructions from tubular anatomical structures such as blood vessels
US5957882A (en) * 1991-01-11 1999-09-28 Advanced Cardiovascular Systems, Inc. Ultrasound devices for ablating and removing obstructive matter from anatomical passageways and blood vessels
US5368557A (en) 1991-01-11 1994-11-29 Baxter International Inc. Ultrasonic ablation catheter device having multiple ultrasound transmission members
US5368558A (en) * 1991-01-11 1994-11-29 Baxter International Inc. Ultrasonic ablation catheter device having endoscopic component and method of using same
US5997497A (en) * 1991-01-11 1999-12-07 Advanced Cardiovascular Systems Ultrasound catheter having integrated drug delivery system and methods of using same
JP2509412B2 (en) * 1991-05-09 1996-06-19 サムスン エレクトロニクス カンパニー リミテッド Method for manufacturing semiconductor device
US5234416A (en) 1991-06-06 1993-08-10 Advanced Cardiovascular Systems, Inc. Intravascular catheter with a nontraumatic distal tip
US5795325A (en) 1991-07-16 1998-08-18 Heartport, Inc. Methods and apparatus for anchoring an occluding member
US5242385A (en) 1991-10-08 1993-09-07 Surgical Design Corporation Ultrasonic handpiece
US5376084A (en) 1991-10-17 1994-12-27 Imagyn Medical, Inc. Catheter with internal mandrel and method
WO1993008750A2 (en) 1991-11-04 1993-05-13 Baxter International Inc. Ultrasonic ablation device adapted for guidewire passage
US5325860A (en) 1991-11-08 1994-07-05 Mayo Foundation For Medical Education And Research Ultrasonic and interventional catheter and method
US5217565A (en) 1991-11-13 1993-06-08 Wisconsin Alumni Research Foundation Contactless heater floating zone refining and crystal growth
US5695510A (en) 1992-02-20 1997-12-09 Hood; Larry L. Ultrasonic knife
US5269297A (en) 1992-02-27 1993-12-14 Angiosonics Inc. Ultrasonic transmission apparatus
US5226421A (en) 1992-03-06 1993-07-13 Cardiometrics, Inc. Doppler elongate flexible member having an inflatable balloon mounted thereon
US6497709B1 (en) 1992-03-31 2002-12-24 Boston Scientific Corporation Metal medical device
US5324260A (en) * 1992-04-27 1994-06-28 Minnesota Mining And Manufacturing Company Retrograde coronary sinus catheter
EP0820727B1 (en) 1992-05-05 1999-12-15 Advanced Cardiovascular Systems, Inc. Ultrasonic angioplasty catheter device
US5290230A (en) 1992-05-11 1994-03-01 Advanced Cardiovascular Systems, Inc. Intraluminal catheter with a composite shaft
US6936025B1 (en) 1992-05-19 2005-08-30 Bacchus Vascular, Inc. Thrombolysis device
US5328004A (en) 1992-08-21 1994-07-12 General Motors Corporation Bypass valve assembly for a hydraulic damper
US5318014A (en) 1992-09-14 1994-06-07 Coraje, Inc. Ultrasonic ablation/dissolution transducer
US5243997A (en) 1992-09-14 1993-09-14 Interventional Technologies, Inc. Vibrating device for a guide wire
US5362309A (en) 1992-09-14 1994-11-08 Coraje, Inc. Apparatus and method for enhanced intravascular phonophoresis including dissolution of intravascular blockage and concomitant inhibition of restenosis
US5443078A (en) 1992-09-14 1995-08-22 Interventional Technologies, Inc. Method for advancing a guide wire
CA2150707A1 (en) 1992-12-01 1994-06-09 Mir A. Imram Vibratory element for crossing stenoses
US5329927A (en) 1993-02-25 1994-07-19 Echo Cath, Inc. Apparatus and method for locating an interventional medical device with a ultrasound color imaging system
US5346502A (en) 1993-04-15 1994-09-13 Ultracision, Inc. Laparoscopic ultrasonic surgical instrument and methods for manufacturing the instruments
US5417703A (en) 1993-07-13 1995-05-23 Scimed Life Systems, Inc. Thrombectomy devices and methods of using same
US5431168A (en) 1993-08-23 1995-07-11 Cordis-Webster, Inc. Steerable open-lumen catheter
US5427118A (en) 1993-10-04 1995-06-27 Baxter International Inc. Ultrasonic guidewire
US5465733A (en) 1993-10-14 1995-11-14 Hinohara; Tomoaki Guide wire for catheters and method for its use
JPH07116260A (en) 1993-10-27 1995-05-09 Sumitomo Bakelite Co Ltd Catheter for medical treatment and its production
US5421923A (en) 1993-12-03 1995-06-06 Baxter International, Inc. Ultrasonic welding horn with sonics dampening insert
EP1129744B2 (en) 1993-12-03 2014-05-07 Edwards Lifesciences AG Cardiopulmonary bypass system for closed-chest intervention
WO1995016141A1 (en) 1993-12-09 1995-06-15 Devices For Vascular Intervention, Inc. Composite drive shaft
US5658282A (en) 1994-01-18 1997-08-19 Endovascular, Inc. Apparatus for in situ saphenous vein bypass and less-invasive varicose vein treatment
FR2715588B1 (en) 1994-02-03 1996-03-01 Aerospatiale Ultrasonic percussion device.
JP3425615B2 (en) 1994-03-24 2003-07-14 科学技術庁長官官房会計課長 Scanning near-field atomic force microscope
US6729334B1 (en) 1994-06-17 2004-05-04 Trudell Medical Limited Nebulizing catheter system and methods of use and manufacture
NZ272354A (en) 1994-06-17 1997-10-24 Trudell Medical Ltd Catheter system; method and apparatus for delivering an aerosol form of medication to the lungs, details of method and of catheter apparatus
US5516043A (en) 1994-06-30 1996-05-14 Misonix Inc. Ultrasonic atomizing device
US5509896A (en) 1994-09-09 1996-04-23 Coraje, Inc. Enhancement of thrombolysis with external ultrasound
WO1996010366A1 (en) 1994-10-03 1996-04-11 Heart Technology, Inc. Transluminal thrombectomy apparatus
US5527273A (en) 1994-10-06 1996-06-18 Misonix, Inc. Ultrasonic lipectomy probe and method for manufacture
US6607698B1 (en) 1997-08-15 2003-08-19 Therox, Inc. Method for generalized extracorporeal support
US5597497A (en) 1994-12-20 1997-01-28 Hypertherm, Inc. Switch mechanism for operating a plasma arc torch, other tools or weapons
WO1996035469A1 (en) 1995-05-10 1996-11-14 Cardiogenesis Corporation System for treating or diagnosing heart tissue
CA2225784A1 (en) * 1995-06-30 1997-01-23 Boston Scientific Corporation Ultrasound imaging catheter with a cutting element
AU6713696A (en) 1995-08-01 1997-02-26 Auravision Corporation Transition aligned video synchronization system
US5685841A (en) 1995-08-14 1997-11-11 Mackool; Richard J. Support for fluid infusion tube for use during eye surgery
US6302875B1 (en) 1996-10-11 2001-10-16 Transvascular, Inc. Catheters and related devices for forming passageways between blood vessels or other anatomical structures
EP0955933B1 (en) 1995-10-13 2009-08-26 Medtronic Vascular, Inc. A device for interstitial transvascular intervention
US6283983B1 (en) 1995-10-13 2001-09-04 Transvascular, Inc. Percutaneous in-situ coronary bypass method and apparatus
US5957899A (en) 1995-11-27 1999-09-28 Therox, Inc. High pressure transluminal fluid delivery device
US6235007B1 (en) 1995-11-27 2001-05-22 Therox, Inc. Atraumatic fluid delivery devices
US5797876A (en) 1995-11-27 1998-08-25 Therox, Inc. High pressure perfusion device
US5843109A (en) 1996-05-29 1998-12-01 Allergan Ultrasonic handpiece with multiple piezoelectric elements and heat dissipator
US5827971A (en) 1996-05-31 1998-10-27 Lockheed Martin Idaho Technologies Company Optical vibration detection spectral analysis assembly and method for detecting vibration in an object of interest
US6652546B1 (en) * 1996-07-26 2003-11-25 Kensey Nash Corporation System and method of use for revascularizing stenotic bypass grafts and other occluded blood vessels
US6241703B1 (en) 1996-08-19 2001-06-05 Angiosonics Inc. Ultrasound transmission apparatus having a tip
US5971949A (en) 1996-08-19 1999-10-26 Angiosonics Inc. Ultrasound transmission apparatus and method of using same
US5846218A (en) 1996-09-05 1998-12-08 Pharmasonics, Inc. Balloon catheters having ultrasonically driven interface surfaces and methods for their use
US5989274A (en) 1996-10-17 1999-11-23 Ethicon Endo-Surgery, Inc. Methods and devices for improving blood flow to a heart of a patient
US6165188A (en) 1996-12-02 2000-12-26 Angiotrax, Inc. Apparatus for percutaneously performing myocardial revascularization having controlled cutting depth and methods of use
US6048329A (en) 1996-12-19 2000-04-11 Ep Technologies, Inc. Catheter distal assembly with pull wires
JPH10216140A (en) 1997-02-12 1998-08-18 Olympus Optical Co Ltd Ultrasonic therapeutic system
US5989275A (en) 1997-02-28 1999-11-23 Ethicon Endo-Surgery, Inc. Damping ultrasonic transmission components
US5944737A (en) 1997-10-10 1999-08-31 Ethicon Endo-Surgery, Inc. Ultrasonic clamp coagulator apparatus having improved waveguide support member
US5904667A (en) 1997-03-17 1999-05-18 C.R. Bard, Inc. Rotatable control mechanism for steerable catheter
US5827203A (en) 1997-04-21 1998-10-27 Nita; Henry Ultrasound system and method for myocardial revascularization
US5989208A (en) * 1997-05-16 1999-11-23 Nita; Henry Therapeutic ultrasound system
JP2002515813A (en) 1997-05-23 2002-05-28 バイオセンス・インコーポレイテッド Catheter with obliquely extending lumen
US5916912A (en) * 1997-06-16 1999-06-29 The Regents Of The University Of California Dietary composition for enhancing metabolism and alleviating oxidative stress
US6071292A (en) 1997-06-28 2000-06-06 Transvascular, Inc. Transluminal methods and devices for closing, forming attachments to, and/or forming anastomotic junctions in, luminal anatomical structures
US6004280A (en) 1997-08-05 1999-12-21 Cordis Corporation Guiding sheath having three-dimensional distal end
US6024764A (en) 1997-08-19 2000-02-15 Intermedics, Inc. Apparatus for imparting physician-determined shapes to implantable tubular devices
US5937301A (en) 1997-08-19 1999-08-10 Advanced Micro Devices Method of making a semiconductor device having sidewall spacers with improved profiles
US5902287A (en) 1997-08-20 1999-05-11 Medtronic, Inc. Guiding catheter and method of making same
US6113558A (en) 1997-09-29 2000-09-05 Angiosonics Inc. Pulsed mode lysis method
US6007514A (en) * 1997-09-30 1999-12-28 Nita; Henry Ultrasound system with pathfinding guidewire
US6007499A (en) * 1997-10-31 1999-12-28 University Of Washington Method and apparatus for medical procedures using high-intensity focused ultrasound
US6183432B1 (en) 1997-11-13 2001-02-06 Lumend, Inc. Guidewire and catheter with rotating and reciprocating symmetrical or asymmetrical distal tip
US6159165A (en) 1997-12-05 2000-12-12 Micrus Corporation Three dimensional spherical micro-coils manufactured from radiopaque nickel-titanium microstrand
US6159176A (en) 1997-12-11 2000-12-12 Sonics & Materials Inc. Sheath and support for ultrasonic elongate tip
US5808153A (en) * 1997-12-12 1998-09-15 Prasad; Vidyanatha A. Conversion of N-(4-fluorophenyl)-2-hydroxy-N-(1-methylethyl) acetamide acetate to N-4-fluorophenyl)-2-hydroxy-N-(1-methylethyl) acetamide
DE19800416C2 (en) 1998-01-08 2002-09-19 Storz Karl Gmbh & Co Kg Device for the treatment of body tissue, in particular soft tissue close to the surface, by means of ultrasound
US6221425B1 (en) 1998-01-30 2001-04-24 Advanced Cardiovascular Systems, Inc. Lubricious hydrophilic coating for an intracorporeal medical device
JP3559441B2 (en) 1998-03-05 2004-09-02 テルモ株式会社 Tube unit system
DE19814395C2 (en) 1998-03-31 2000-09-21 Ferton Holding Sa Flexible metal probe for use in intracorporeal shock wave lithotripsy
US5935144A (en) 1998-04-09 1999-08-10 Ethicon Endo-Surgery, Inc. Double sealed acoustic isolation members for ultrasonic
US6126684A (en) * 1998-04-21 2000-10-03 The Regents Of The University Of California Indwelling heat exchange catheter and method of using same
US6331171B1 (en) 1998-06-04 2001-12-18 Alcon Laboratories, Inc. Tip for a liquefracture handpiece
EP1096965B1 (en) 1998-07-16 2007-12-05 Mark Cohen Reinforced variable stiffness tubing
US6602467B1 (en) 1998-07-24 2003-08-05 Therox, Inc. Apparatus and method for blood oxygenation
US6573470B1 (en) * 1998-08-05 2003-06-03 Dct, Inc. Weld gun heat removal
US6241692B1 (en) * 1998-10-06 2001-06-05 Irvine Biomedical, Inc. Ultrasonic ablation device and methods for lead extraction
US7621893B2 (en) 1998-10-29 2009-11-24 Medtronic Minimed, Inc. Methods and apparatuses for detecting occlusions in an ambulatory infusion pump
US6149596A (en) 1998-11-05 2000-11-21 Bancroft; Michael R. Ultrasonic catheter apparatus and method
KR100501640B1 (en) 1998-12-01 2005-07-18 한국전력공사 Method and device for incineration and vitrification of waste, in particular radioactive waste
US8506519B2 (en) 1999-02-16 2013-08-13 Flowcardia, Inc. Pre-shaped therapeutic catheter
US20040024393A1 (en) 2002-08-02 2004-02-05 Henry Nita Therapeutic ultrasound system
US6210408B1 (en) 1999-02-24 2001-04-03 Scimed Life Systems, Inc. Guide wire system for RF recanalization of vascular blockages
CA2299997A1 (en) 1999-03-05 2000-09-05 Thomas Peterson Method and apparatus for cleaning medical instruments and the like
US6484052B1 (en) 1999-03-30 2002-11-19 The Regents Of The University Of California Optically generated ultrasound for enhanced drug delivery
US6398736B1 (en) * 1999-03-31 2002-06-04 Mayo Foundation For Medical Education And Research Parametric imaging ultrasound catheter
JP2000291543A (en) 1999-04-05 2000-10-17 Rozensutaa Kk Air pump for wine bottle
ATE353001T1 (en) * 1999-05-11 2007-02-15 Atrionix Inc BALLOON ANCHORING WIRE
WO2000067830A1 (en) 1999-05-11 2000-11-16 Atrionix, Inc. Catheter positioning system
US7935108B2 (en) 1999-07-14 2011-05-03 Cardiofocus, Inc. Deflectable sheath catheters
US6719715B2 (en) 1999-09-16 2004-04-13 Vasogen Ireland Limited Apparatus and process for conditioning organic fluid
US6759008B1 (en) 1999-09-30 2004-07-06 Therox, Inc. Apparatus and method for blood oxygenation
US6596235B2 (en) 1999-09-30 2003-07-22 Therox, Inc. Method for blood oxygenation
US6387324B1 (en) 1999-09-30 2002-05-14 Therox, Inc. Apparatus and method for blood oxygenation
US6652547B2 (en) 1999-10-05 2003-11-25 Omnisonics Medical Technologies, Inc. Apparatus and method of removing occlusions using ultrasonic medical device operating in a transverse mode
US6733451B2 (en) 1999-10-05 2004-05-11 Omnisonics Medical Technologies, Inc. Apparatus and method for an ultrasonic probe used with a pharmacological agent
JP2001104356A (en) 1999-10-08 2001-04-17 Toshiba Corp Ultrasonic therapy apparatus
JP2001116565A (en) 1999-10-15 2001-04-27 Yazaki Corp On-vehicle navigation system and recording medium where processing program is recorded for it
US6296620B1 (en) * 1999-12-09 2001-10-02 Advanced Cardiovascular Systems, Inc. Polymer blends for ultrasonic catheters
US6423026B1 (en) 1999-12-09 2002-07-23 Advanced Cardiovascular Systems, Inc. Catheter stylet
US6494891B1 (en) 1999-12-30 2002-12-17 Advanced Cardiovascular Systems, Inc. Ultrasonic angioplasty transmission member
US6589253B1 (en) 1999-12-30 2003-07-08 Advanced Cardiovascular Systems, Inc. Ultrasonic angioplasty transmission wire
US7166098B1 (en) 1999-12-30 2007-01-23 Advanced Cardiovascular Systems, Inc. Medical assembly with transducer for local delivery of a therapeutic substance and method of using same
US6450975B1 (en) 1999-12-30 2002-09-17 Advanced Cardiovascular Systems, Inc. Ultrasonic transmission guide wire
US6758846B2 (en) 2000-02-08 2004-07-06 Gyrus Medical Limited Electrosurgical instrument and an electrosurgery system including such an instrument
US6635017B1 (en) 2000-02-09 2003-10-21 Spentech, Inc. Method and apparatus combining diagnostic ultrasound with therapeutic ultrasound to enhance thrombolysis
US6394956B1 (en) * 2000-02-29 2002-05-28 Scimed Life Systems, Inc. RF ablation and ultrasound catheter for crossing chronic total occlusions
US6494894B2 (en) 2000-03-16 2002-12-17 Scimed Life Systems, Inc. Coated wire
US6434418B1 (en) 2000-04-12 2002-08-13 Randall H. Neal Apparatus for measuring intrauterine pressure and fetal heart rate and method for using same
US6650923B1 (en) 2000-04-13 2003-11-18 Ev3 Sunnyvale, Inc. Method for accessing the left atrium of the heart by locating the fossa ovalis
US7056294B2 (en) 2000-04-13 2006-06-06 Ev3 Sunnyvale, Inc Method and apparatus for accessing the left atrial appendage
JP2001321388A (en) 2000-05-17 2001-11-20 Aloka Co Ltd Ultrasonic surgical tool
US6761698B2 (en) 2000-07-28 2004-07-13 Olympus Corporation Ultrasonic operation system
JP2002186627A (en) 2000-10-11 2002-07-02 Olympus Optical Co Ltd Ultrasonic manipulation device
US6622542B2 (en) 2001-03-20 2003-09-23 Therox, Inc. Bubble detector and method of use thereof
US6582387B2 (en) 2001-03-20 2003-06-24 Therox, Inc. System for enriching a bodily fluid with a gas
US6613280B2 (en) 2001-03-20 2003-09-02 Therox, Inc. Disposable cartridge for producing gas-enriched fluids
US6623448B2 (en) 2001-03-30 2003-09-23 Advanced Cardiovascular Systems, Inc. Steerable drug delivery device
US6615062B2 (en) 2001-05-31 2003-09-02 Infraredx, Inc. Referencing optical catheters
US8974446B2 (en) 2001-10-11 2015-03-10 St. Jude Medical, Inc. Ultrasound ablation apparatus with discrete staggered ablation zones
EP1434615B1 (en) 2001-10-11 2007-07-11 Emphasys Medical, Inc. Bronchial flow control device
US20030216732A1 (en) * 2002-05-20 2003-11-20 Csaba Truckai Medical instrument with thermochromic or piezochromic surface indicators
US7776025B2 (en) 2001-10-29 2010-08-17 Edwards Lifesciences Corporation Method for providing medicament to tissue
US7150853B2 (en) 2001-11-01 2006-12-19 Advanced Cardiovascular Systems, Inc. Method of sterilizing a medical device
KR100572236B1 (en) 2001-11-14 2006-04-19 가부시끼가이샤 도시바 Ultrasonic Examination Devices, Ultrasonic Transducers, and Ultrasound Imaging Devices
AU2002353016A1 (en) 2001-12-03 2003-06-17 Ekos Corporation Small vessel ultrasound catheter
AU2007240154B2 (en) 2001-12-21 2010-08-12 Sound Surgical Technologies, Llc Pulsed ultrasonic device and method
JP2003190180A (en) 2001-12-27 2003-07-08 Miwatec:Kk Compound vibration ultrasonic hand piece
JP4109096B2 (en) 2002-01-11 2008-06-25 オリンパス株式会社 Ultrasonic treatment device
AU2003212481A1 (en) 2002-02-28 2003-09-09 Ekos Corporation Ultrasound assembly for use with a catheter
JP2004000336A (en) 2002-05-31 2004-01-08 Olympus Corp Ultrasonic treatment apparatus
US6702748B1 (en) 2002-09-20 2004-03-09 Flowcardia, Inc. Connector for securing ultrasound catheter to transducer
US8133236B2 (en) 2006-11-07 2012-03-13 Flowcardia, Inc. Ultrasound catheter having protective feature against breakage
US7137963B2 (en) 2002-08-26 2006-11-21 Flowcardia, Inc. Ultrasound catheter for disrupting blood vessel obstructions
US6942677B2 (en) 2003-02-26 2005-09-13 Flowcardia, Inc. Ultrasound catheter apparatus
US7604608B2 (en) 2003-01-14 2009-10-20 Flowcardia, Inc. Ultrasound catheter and methods for making and using same
US7220233B2 (en) 2003-04-08 2007-05-22 Flowcardia, Inc. Ultrasound catheter devices and methods
US6942620B2 (en) 2002-09-20 2005-09-13 Flowcardia Inc Connector for securing ultrasound catheter to transducer
US7267650B2 (en) 2002-12-16 2007-09-11 Cardiac Pacemakers, Inc. Ultrasound directed guiding catheter system and method
US20080208084A1 (en) 2003-02-05 2008-08-28 Timi 3 Systems, Inc. Systems and methods for applying ultrasound energy to increase tissue perfusion and/or vasodilation without substantial deep heating of tissue
EP1641512A1 (en) 2003-06-20 2006-04-05 Coloplast A/S A medical device comprising a braided portion
US7004176B2 (en) 2003-10-17 2006-02-28 Edwards Lifesciences Ag Heart valve leaflet locator
WO2005072409A2 (en) 2004-01-29 2005-08-11 Ekos Corporation Method and apparatus for detecting vascular conditions with a catheter
US7341569B2 (en) 2004-01-30 2008-03-11 Ekos Corporation Treatment of vascular occlusions using ultrasonic energy and microbubbles
JP4253605B2 (en) 2004-03-15 2009-04-15 オリンパス株式会社 Ultrasonic treatment device
US20050228286A1 (en) 2004-04-07 2005-10-13 Messerly Jeffrey D Medical system having a rotatable ultrasound source and a piercing tip
US7540852B2 (en) * 2004-08-26 2009-06-02 Flowcardia, Inc. Ultrasound catheter devices and methods
JP4183669B2 (en) 2004-09-16 2008-11-19 三洋電機株式会社 Digital watermark embedding apparatus and method, and digital watermark extraction apparatus and method
WO2006049593A1 (en) 2004-10-27 2006-05-11 Omnisonics Medical Technologies, Inc. Apparatus and method for using an ultrasonic medical device to reinforce bone
US8221343B2 (en) 2005-01-20 2012-07-17 Flowcardia, Inc. Vibrational catheter devices and methods for making same
CA2604380A1 (en) 2005-04-12 2006-10-19 Ekos Corporation Ultrasound catheter with cavitation promoting surface
US7771358B2 (en) 2005-05-20 2010-08-10 Spentech, Inc. System and method for grading microemboli monitored by a multi-gate doppler ultrasound system
US20110313328A1 (en) 2005-06-24 2011-12-22 Penumbra, Inc. Methods and apparatus for dissolving blockages in intracranial catheters
US20120330196A1 (en) 2005-06-24 2012-12-27 Penumbra Inc. Methods and Apparatus for Removing Blood Clots and Tissue from the Patient's Head
US8025655B2 (en) 2005-09-12 2011-09-27 Bridgepoint Medical, Inc. Endovascular devices and methods
US8083727B2 (en) 2005-09-12 2011-12-27 Bridgepoint Medical, Inc. Endovascular devices and methods for exploiting intramural space
JP2007116260A (en) 2005-10-18 2007-05-10 Kyocera Corp Communication apparatus and communication method
US7850623B2 (en) 2005-10-27 2010-12-14 Boston Scientific Scimed, Inc. Elongate medical device with continuous reinforcement member
US9282984B2 (en) 2006-04-05 2016-03-15 Flowcardia, Inc. Therapeutic ultrasound system
US7819013B2 (en) 2006-07-05 2010-10-26 The Hong Kong Polytechnic University Method and apparatus for measuring oscillation amplitude of an ultrasonic device
US20080071343A1 (en) 2006-09-15 2008-03-20 Kevin John Mayberry Multi-segmented graft deployment system
US8246643B2 (en) 2006-11-07 2012-08-21 Flowcardia, Inc. Ultrasound catheter having improved distal end
US7775994B2 (en) 2006-12-11 2010-08-17 Emigrant Bank, N.A. Ultrasound medical systems and related methods
GB0822110D0 (en) 2008-12-03 2009-01-07 Angiomed Ag Catheter sheath for implant delivery
US8226566B2 (en) 2009-06-12 2012-07-24 Flowcardia, Inc. Device and method for vascular re-entry
US20110237982A1 (en) 2009-10-06 2011-09-29 Wallace Michael P Ultrasound-enhanced stenosis therapy
US20110105960A1 (en) 2009-10-06 2011-05-05 Wallace Michael P Ultrasound-enhanced Stenosis therapy
US20120130475A1 (en) 2010-11-16 2012-05-24 Shaw Edward E Sleeves for expandable medical devices
JP6293145B2 (en) 2012-08-02 2018-03-14 バード・ペリフェラル・バスキュラー・インコーポレーテッド Ultrasound catheter system
US20140243712A1 (en) 2013-02-28 2014-08-28 Doheny Eye Institute Thrombolysis in retinal vessels with ultrasound
US11083869B2 (en) 2015-03-16 2021-08-10 Bard Peripheral Vascular, Inc. Braided crescent ribbon catheter reinforcement

Patent Citations (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3433266A (en) * 1967-03-22 1969-03-18 Moog Inc Positive centering servovalve having movable spring backup
US3565062A (en) * 1968-06-13 1971-02-23 Ultrasonic Systems Ultrasonic method and apparatus for removing cholesterol and other deposits from blood vessels and the like
US3631848A (en) * 1968-09-04 1972-01-04 Us Catheter & Instr Corp Extensible catheter
US3719737A (en) * 1970-12-09 1973-03-06 Bard Inc C R Method of making a preformed curved epidural catheter
US4016882A (en) * 1975-03-05 1977-04-12 Cavitron Corporation Neurosonic aspirator and method
US4136700A (en) * 1975-03-05 1979-01-30 Cavitron Corporation Neurosonic aspirator
US4425115A (en) * 1977-12-19 1984-01-10 Wuchinich David G Ultrasonic resonant vibrator
US4368410A (en) * 1980-10-14 1983-01-11 Dynawave Corporation Ultrasound therapy device
US4565589A (en) * 1982-03-05 1986-01-21 Raychem Corporation Nickel/titanium/copper shape memory alloy
US4665906A (en) * 1983-10-14 1987-05-19 Raychem Corporation Medical devices incorporating sim alloy elements
US4572184A (en) * 1983-10-28 1986-02-25 Blackstone Corporation Wave guide attachment means and methods
US5114414A (en) * 1984-09-18 1992-05-19 Medtronic, Inc. Low profile steerable catheter
US4664112A (en) * 1985-08-12 1987-05-12 Intravascular Surgical Instruments, Inc. Catheter based surgical methods and apparatus therefor
US5000185A (en) * 1986-02-28 1991-03-19 Cardiovascular Imaging Systems, Inc. Method for intravascular two-dimensional ultrasonography and recanalization
US4827911A (en) * 1986-04-02 1989-05-09 Cooper Lasersonics, Inc. Method and apparatus for ultrasonic surgical fragmentation and removal of tissue
US6702750B2 (en) * 1986-04-15 2004-03-09 Cardiovascular Imaging Systems, Inc. Angioplasty apparatus facilitating rapid exchanges and methods
US4721117A (en) * 1986-04-25 1988-01-26 Advanced Cardiovascular Systems, Inc. Torsionally stabilized guide wire with outer jacket
US4808153A (en) * 1986-11-17 1989-02-28 Ultramed Corporation Device for removing plaque from arteries
US4923462A (en) * 1987-03-17 1990-05-08 Cordis Corporation Catheter system having a small diameter rotatable drive member
US5116350B1 (en) * 1987-03-17 1997-06-17 Cordis Corp Catheter system having distal tip for opening obstructions
US5116350A (en) * 1987-03-17 1992-05-26 Cordis Corporation Catheter system having distal tip for opening obstructions
US4811743A (en) * 1987-04-21 1989-03-14 Cordis Corporation Catheter guidewire
US5015227A (en) * 1987-09-30 1991-05-14 Valleylab Inc. Apparatus for providing enhanced tissue fragmentation and/or hemostasis
US5720724A (en) * 1988-02-29 1998-02-24 Scimed Life Systems, Inc. Intravascular catheter with distal guide wire lumen and transition member
US5715825A (en) * 1988-03-21 1998-02-10 Boston Scientific Corporation Acoustic imaging catheter and the like
US4924863A (en) * 1988-05-04 1990-05-15 Mmtc, Inc. Angioplastic method for removing plaque from a vas
US4920954A (en) * 1988-08-05 1990-05-01 Sonic Needle Corporation Ultrasonic device for applying cavitation forces
US5091205A (en) * 1989-01-17 1992-02-25 Union Carbide Chemicals & Plastics Technology Corporation Hydrophilic lubricious coatings
US5180363A (en) * 1989-04-27 1993-01-19 Sumitomo Bakelite Company Company Limited Operation device
US5109859A (en) * 1989-10-04 1992-05-05 Beth Israel Hospital Association Ultrasound guided laser angioplasty
US5195955A (en) * 1989-11-14 1993-03-23 Don Michael T Anthony Device for removal of embolic debris
US5895397A (en) * 1990-05-21 1999-04-20 Cardiovascular Imaging Systems, Inc. Intravascular catheter having combined imaging abrasion head
US6217543B1 (en) * 1990-07-17 2001-04-17 Aziz Yehia Anis Removal of tissue
US5100423A (en) * 1990-08-21 1992-03-31 Medical Engineering & Development Institute, Inc. Ablation catheter
US5380316A (en) * 1990-12-18 1995-01-10 Advanced Cardiovascular Systems, Inc. Method for intra-operative myocardial device revascularization
US5389096A (en) * 1990-12-18 1995-02-14 Advanced Cardiovascular Systems System and method for percutaneous myocardial revascularization
US5312328A (en) * 1991-01-11 1994-05-17 Baxter International Inc. Ultra-sound catheter for removing obstructions from tubular anatomical structures such as blood vessels
US5380274A (en) * 1991-01-11 1995-01-10 Baxter International Inc. Ultrasound transmission member having improved longitudinal transmission properties
US5304115A (en) * 1991-01-11 1994-04-19 Baxter International Inc. Ultrasonic angioplasty device incorporating improved transmission member and ablation probe
US5397301A (en) * 1991-01-11 1995-03-14 Baxter International Inc. Ultrasonic angioplasty device incorporating an ultrasound transmission member made at least partially from a superelastic metal alloy
US5183470A (en) * 1991-03-04 1993-02-02 International Medical, Inc. Laparoscopic cholangiogram catheter and method of using same
US5607421A (en) * 1991-05-01 1997-03-04 The Trustees Of Columbia University In The City Of New York Myocardial revascularization through the endocardial surface using a laser
US5480379A (en) * 1991-05-22 1996-01-02 La Rosa; Antonio Ultrasonic dissector and detacher for atherosclerotic plaque and method of using same
US5304131A (en) * 1991-07-15 1994-04-19 Paskar Larry D Catheter
US5290229A (en) * 1991-07-15 1994-03-01 Paskar Larry D Transformable catheter and method
US6029671A (en) * 1991-07-16 2000-02-29 Heartport, Inc. System and methods for performing endovascular procedures
US5597882A (en) * 1991-11-15 1997-01-28 Wacker-Chemie Gmbh Tin compound-containing compositions as one of the two components of two component systems which crosslink at room temperature to give organopolysiloxane elastomers
US5405318A (en) * 1992-05-05 1995-04-11 Baxter International Inc. Ultra-sound catheter for removing obstructions from tubular anatomical structures such as blood vessels
US5382228A (en) * 1992-07-09 1995-01-17 Baxter International Inc. Method and device for connecting ultrasound transmission member (S) to an ultrasound generating device
US5287858A (en) * 1992-09-23 1994-02-22 Pilot Cardiovascular Systems, Inc. Rotational atherectomy guidewire
US5383460A (en) * 1992-10-05 1995-01-24 Cardiovascular Imaging Systems, Inc. Method and apparatus for ultrasound imaging and atherectomy
US5397293A (en) * 1992-11-25 1995-03-14 Misonix, Inc. Ultrasonic device with sheath and transverse motion damping
US5409483A (en) * 1993-01-22 1995-04-25 Jeffrey H. Reese Direct visualization surgical probe
US5611807A (en) * 1993-02-05 1997-03-18 The Joe W. & Dorothy Dorsett Brown Foundation Ultrasonic angioplasty balloon catheter
US5378234A (en) * 1993-03-15 1995-01-03 Pilot Cardiovascular Systems, Inc. Coil polymer composite
US6547754B1 (en) * 1993-05-19 2003-04-15 Bacchus Vascular, Inc. Thrombolysis device
US5487757A (en) * 1993-07-20 1996-01-30 Medtronic Cardiorhythm Multicurve deflectable catheter
US5417672A (en) * 1993-10-04 1995-05-23 Baxter International Inc. Connector for coupling an ultrasound transducer to an ultrasound catheter
US5484398A (en) * 1994-03-17 1996-01-16 Valleylab Inc. Methods of making and using ultrasonic handpiece
US5618266A (en) * 1994-03-31 1997-04-08 Liprie; Samuel F. Catheter for maneuvering radioactive source wire to site of treatment
US5507738A (en) * 1994-08-05 1996-04-16 Microsonic Engineering Devices Company, Inc. Ultrasonic vascular surgical system
US6689086B1 (en) * 1994-10-27 2004-02-10 Advanced Cardiovascular Systems, Inc. Method of using a catheter for delivery of ultrasonic energy and medicament
US6676900B1 (en) * 1994-12-09 2004-01-13 Therox, Inc. Method for the preparation and delivery of gas-enriched fluids
US6180059B1 (en) * 1995-06-05 2001-01-30 Therox, Inc. Method for the preparation and delivery of gas-enriched fluids
US5738100A (en) * 1995-06-30 1998-04-14 Terumo Kabushiki Kaisha Ultrasonic imaging catheter
US6190353B1 (en) * 1995-10-13 2001-02-20 Transvascular, Inc. Methods and apparatus for bypassing arterial obstructions and/or performing other transvascular procedures
US5728062A (en) * 1995-11-30 1998-03-17 Pharmasonics, Inc. Apparatus and methods for vibratory intraluminal therapy employing magnetostrictive transducers
US6022309A (en) * 1996-04-24 2000-02-08 The Regents Of The University Of California Opto-acoustic thrombolysis
US6051010A (en) * 1996-12-23 2000-04-18 Ethicon Endo-Surgery, Inc. Methods and devices for joining transmission components
US5893838A (en) * 1997-08-15 1999-04-13 Therox, Inc. System and method for high pressure delivery of gas-supersaturated fluids
US6030357A (en) * 1997-08-15 2000-02-29 Therox, Inc. System and method for high pressure delivery of gas-supersaturated fluids
US6179809B1 (en) * 1997-09-24 2001-01-30 Eclipse Surgical Technologies, Inc. Drug delivery catheter with tip alignment
US6695810B2 (en) * 1997-11-21 2004-02-24 Advanced Interventional Technologies, Inc. Endolumenal aortic isolation assembly and method
US6511458B2 (en) * 1998-01-13 2003-01-28 Lumend, Inc. Vascular re-entry catheter
US6719725B2 (en) * 1998-01-13 2004-04-13 Lumend, Inc. Re-entry catheter
US6533766B1 (en) * 1998-07-24 2003-03-18 Therox, Inc. Coating medical device surfaces for delivering gas-supersaturated fluids
US20030009153A1 (en) * 1998-07-29 2003-01-09 Pharmasonics, Inc. Ultrasonic enhancement of drug injection
US6206842B1 (en) * 1998-08-03 2001-03-27 Lily Chen Tu Ultrasonic operation device
US6210356B1 (en) * 1998-08-05 2001-04-03 Ekos Corporation Ultrasound assembly for use with a catheter
US6544215B1 (en) * 1998-10-02 2003-04-08 Scimed Life Systems, Inc. Steerable device for introducing diagnostic and therapeutic apparatus into the body
US6685657B2 (en) * 1998-11-20 2004-02-03 Joie P. Jones Methods for selectively dissolving and removing materials using ultra-high frequency ultrasound
US6682502B2 (en) * 1999-03-26 2004-01-27 Transon, Llc Apparatus for emergency treatment of patients experiencing a thrombotic vascular occlusion
US6346192B2 (en) * 1999-05-14 2002-02-12 Therox, Inc. Apparatus for high pressure fluid filtration
US6555059B1 (en) * 1999-09-30 2003-04-29 Therox, Inc. Method of forming gas-enriched fluid
US6695782B2 (en) * 1999-10-05 2004-02-24 Omnisonics Medical Technologies, Inc. Ultrasonic probe device with rapid attachment and detachment means
US6866670B2 (en) * 1999-10-05 2005-03-15 Omnisonics Medical Technologies, Inc. Apparatus for removing plaque from blood vessels using ultrasonic energy
US20030036705A1 (en) * 1999-10-05 2003-02-20 Omnisonics Medical Technologies, Inc. Ultrasonic probe device having an impedance mismatch with rapid attachment and detachment means
US7503895B2 (en) * 1999-10-05 2009-03-17 Omnisonics Medical Technologies, Inc. Ultrasonic device for tissue ablation and sheath for use therewith
US6551337B1 (en) * 1999-10-05 2003-04-22 Omnisonics Medical Technologies, Inc. Ultrasonic medical device operating in a transverse mode
US6695781B2 (en) * 1999-10-05 2004-02-24 Omnisonics Medical Technologies, Inc. Ultrasonic medical device for tissue remodeling
US6524251B2 (en) * 1999-10-05 2003-02-25 Omnisonics Medical Technologies, Inc. Ultrasonic device for tissue ablation and sheath for use therewith
US7494468B2 (en) * 1999-10-05 2009-02-24 Omnisonics Medical Technologies, Inc. Ultrasonic medical device operating in a transverse mode
US6508781B1 (en) * 1999-12-30 2003-01-21 Advanced Cardiovascular Systems, Inc. Ultrasonic ablation catheter transmission wire connector assembly
US6379378B1 (en) * 2000-03-03 2002-04-30 Innercool Therapies, Inc. Lumen design for catheter
US6508784B1 (en) * 2000-05-19 2003-01-21 Yan-Ho Shu Balloon catheter having adjustable centering capabilities and methods thereof
US7004173B2 (en) * 2000-12-05 2006-02-28 Lumend, Inc. Catheter system for vascular re-entry from a sub-intimal space
US6554846B2 (en) * 2001-09-28 2003-04-29 Scimed Life Systems, Inc. Sonic burr
US6855123B2 (en) * 2002-08-02 2005-02-15 Flow Cardia, Inc. Therapeutic ultrasound system
US7335180B2 (en) * 2003-11-24 2008-02-26 Flowcardia, Inc. Steerable ultrasound catheter
US20070037119A1 (en) * 2005-08-11 2007-02-15 Cook Incorporated System for breaking up thrombi and plaque in the vasculature

Cited By (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8690818B2 (en) 1997-05-01 2014-04-08 Ekos Corporation Ultrasound catheter for providing a therapeutic effect to a vessel of a body
US8764700B2 (en) 1998-06-29 2014-07-01 Ekos Corporation Sheath for use with an ultrasound element
US8696612B2 (en) 2001-12-03 2014-04-15 Ekos Corporation Catheter with multiple ultrasound radiating members
US10080878B2 (en) 2001-12-03 2018-09-25 Ekos Corporation Catheter with multiple ultrasound radiating members
US9415242B2 (en) 2001-12-03 2016-08-16 Ekos Corporation Catheter with multiple ultrasound radiating members
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US9943675B1 (en) 2002-04-01 2018-04-17 Ekos Corporation Ultrasonic catheter power control
US8852166B1 (en) 2002-04-01 2014-10-07 Ekos Corporation Ultrasonic catheter power control
US9107590B2 (en) 2004-01-29 2015-08-18 Ekos Corporation Method and apparatus for detecting vascular conditions with a catheter
US10232196B2 (en) 2006-04-24 2019-03-19 Ekos Corporation Ultrasound therapy system
US11058901B2 (en) 2006-04-24 2021-07-13 Ekos Corporation Ultrasound therapy system
US10188410B2 (en) 2007-01-08 2019-01-29 Ekos Corporation Power parameters for ultrasonic catheter
US10182833B2 (en) 2007-01-08 2019-01-22 Ekos Corporation Power parameters for ultrasonic catheter
US11925367B2 (en) 2007-01-08 2024-03-12 Ekos Corporation Power parameters for ultrasonic catheter
US11672553B2 (en) 2007-06-22 2023-06-13 Ekos Corporation Method and apparatus for treatment of intracranial hemorrhages
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US9849273B2 (en) 2009-07-03 2017-12-26 Ekos Corporation Power parameters for ultrasonic catheter
US9192566B2 (en) 2010-02-17 2015-11-24 Ekos Corporation Treatment of vascular occlusions using ultrasonic energy and microbubbles
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US10888657B2 (en) 2010-08-27 2021-01-12 Ekos Corporation Method and apparatus for treatment of intracranial hemorrhages
WO2012052921A1 (en) 2010-10-18 2012-04-26 CardioSonic Ltd. Ultrasound emission element
US10368893B2 (en) 2010-10-18 2019-08-06 CardioSonic Ltd. Ultrasound transducer and uses thereof
US8696581B2 (en) 2010-10-18 2014-04-15 CardioSonic Ltd. Ultrasound transducer and uses thereof
US8585601B2 (en) 2010-10-18 2013-11-19 CardioSonic Ltd. Ultrasound transducer
US10967160B2 (en) 2010-10-18 2021-04-06 CardioSonic Ltd. Tissue treatment
US11730506B2 (en) 2010-10-18 2023-08-22 Sonivie Ltd. Ultrasound transducer and uses thereof
US9326786B2 (en) 2010-10-18 2016-05-03 CardioSonic Ltd. Ultrasound transducer
US9566456B2 (en) 2010-10-18 2017-02-14 CardioSonic Ltd. Ultrasound transceiver and cooling thereof
US9028417B2 (en) 2010-10-18 2015-05-12 CardioSonic Ltd. Ultrasound emission element
WO2012052924A1 (en) 2010-10-18 2012-04-26 CardioSonic Ltd. Separation device for ultrasound element
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US9180315B2 (en) * 2011-06-20 2015-11-10 Olympus Corporation Ultrasonic treatment device and probe unit
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US10357304B2 (en) 2012-04-18 2019-07-23 CardioSonic Ltd. Tissue treatment
US11357447B2 (en) 2012-05-31 2022-06-14 Sonivie Ltd. Method and/or apparatus for measuring renal denervation effectiveness
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US9814901B1 (en) 2013-02-07 2017-11-14 Rocomp Global, L.L.C. Electromagnetic radiation targeting devices, assemblies, systems and methods
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US10688313B2 (en) 2013-02-07 2020-06-23 Rocomp Global, L.L.C. Electromagnetic radiation targeting devices, assemblies, systems and methods
US11491345B2 (en) 2013-02-07 2022-11-08 Rocomp Global, Llc Electromagnetic radiation targeting devices, assemblies, systems and methods
US11491344B2 (en) 2013-02-07 2022-11-08 Rocomp Global, L.L.C. Electromagnetic radiation targeting devices, assemblies, systems and methods
US9814902B1 (en) 2013-02-07 2017-11-14 Rocomp Global, L.L.C. Electromagnetic radiation targeting devices, assemblies, systems and methods
US9717927B2 (en) 2013-02-07 2017-08-01 Rocomp Global, L.L.C. Electromagnetic radiation targeting devices, assemblies, systems and methods
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WO2014124186A3 (en) * 2013-02-07 2015-01-08 Rocomp Global, Llc Electromagnetic radiation targeting devices, assemblies, systems and methods
US9579494B2 (en) 2013-03-14 2017-02-28 Ekos Corporation Method and apparatus for drug delivery to a target site
US10933259B2 (en) 2013-05-23 2021-03-02 CardioSonic Ltd. Devices and methods for renal denervation and assessment thereof
US20180206866A1 (en) * 2014-07-28 2018-07-26 Shaw P. Wan Suction evacuation device
US20210022757A1 (en) * 2014-07-28 2021-01-28 Shaw P. Wan Suction evacuation device
US10828051B2 (en) * 2014-07-28 2020-11-10 Shaw P. Wan Suction evacuation device
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US20160022289A1 (en) * 2014-07-28 2016-01-28 Shaw P. Wan Suction evacuation device
US10507320B2 (en) 2014-09-22 2019-12-17 Ekos Corporation Catheter system
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US20210022759A1 (en) * 2017-01-12 2021-01-28 Shaw P. Wan Suction evacuation device
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US11318331B2 (en) 2017-03-20 2022-05-03 Sonivie Ltd. Pulmonary hypertension treatment

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US20060047239A1 (en) 2006-03-02
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JP4875621B2 (en) 2012-02-15
US20140081288A1 (en) 2014-03-20
US20180280044A1 (en) 2018-10-04
US7540852B2 (en) 2009-06-02
US8617096B2 (en) 2013-12-31
EP1793747A4 (en) 2011-10-05
ES2663681T3 (en) 2018-04-16

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