US20080212405A1 - Mixing Apparatus - Google Patents
Mixing Apparatus Download PDFInfo
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- US20080212405A1 US20080212405A1 US11/428,908 US42890806A US2008212405A1 US 20080212405 A1 US20080212405 A1 US 20080212405A1 US 42890806 A US42890806 A US 42890806A US 2008212405 A1 US2008212405 A1 US 2008212405A1
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- mixing
- mixing element
- planetary
- well
- drive mechanism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/88—Osteosynthesis instruments; Methods or means for implanting or extracting internal or external fixation devices
- A61B17/8802—Equipment for handling bone cement or other fluid fillers
- A61B17/8833—Osteosynthesis tools specially adapted for handling bone cement or fluid fillers; Means for supplying bone cement or fluid fillers to introducing tools, e.g. cartridge handling means
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- A—HUMAN NECESSITIES
- A47—FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
- A47J—KITCHEN EQUIPMENT; COFFEE MILLS; SPICE MILLS; APPARATUS FOR MAKING BEVERAGES
- A47J44/00—Multi-purpose machines for preparing food with several driving units
- A47J44/02—Multi-purpose machines for preparing food with several driving units with provisions for drive either from top or from bottom, e.g. for separately-driven bowl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
- A61F2/4601—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for introducing bone substitute, for implanting bone graft implants or for compacting them in the bone cavity
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/05—Stirrers
- B01F27/11—Stirrers characterised by the configuration of the stirrers
- B01F27/116—Stirrers shaped as cylinders, balls or rollers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/80—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis
- B01F27/95—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis with stirrers having planetary motion, i.e. rotating about their own axis and about a sun axis
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/80—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis
- B01F27/95—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis with stirrers having planetary motion, i.e. rotating about their own axis and about a sun axis
- B01F27/951—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis with stirrers having planetary motion, i.e. rotating about their own axis and about a sun axis with at least one stirrer mounted on the sun axis
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/50—Movable or transportable mixing devices or plants
- B01F33/501—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use
- B01F33/5011—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use portable during use, e.g. hand-held
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/50—Movable or transportable mixing devices or plants
- B01F33/501—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use
- B01F33/5014—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use movable by human force, e.g. kitchen or table devices
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/10—Maintenance of mixers
- B01F35/12—Maintenance of mixers using mechanical means
- B01F35/123—Maintenance of mixers using mechanical means using scrapers for cleaning mixers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/10—Maintenance of mixers
- B01F35/145—Washing or cleaning mixers not provided for in other groups in this subclass; Inhibiting build-up of material on machine parts using other means
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/30—Driving arrangements; Transmissions; Couplings; Brakes
- B01F35/32—Driving arrangements
- B01F35/323—Driving arrangements for vertical stirrer shafts
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/75—Discharge mechanisms
- B01F35/754—Discharge mechanisms characterised by the means for discharging the components from the mixer
- B01F35/75425—Discharge mechanisms characterised by the means for discharging the components from the mixer using pistons or plungers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/75—Discharge mechanisms
- B01F35/754—Discharge mechanisms characterised by the means for discharging the components from the mixer
- B01F35/75425—Discharge mechanisms characterised by the means for discharging the components from the mixer using pistons or plungers
- B01F35/754251—Discharge mechanisms characterised by the means for discharging the components from the mixer using pistons or plungers reciprocating in the mixing receptacle
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30329—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
- A61F2002/30518—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements with possibility of relative movement between the prosthetic parts
- A61F2002/30523—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements with possibility of relative movement between the prosthetic parts by means of meshing gear teeth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
- A61F2002/4685—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor by means of vacuum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
- A61F2002/4688—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor having operating or control means
- A61F2002/4692—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor having operating or control means fluid
- A61F2002/4693—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor having operating or control means fluid hydraulic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/20—Mixing of ingredients for bone cement
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/23—Mixers with rotary stirring devices in fixed receptacles; Kneaders characterised by the orientation or disposition of the rotor axis
- B01F27/232—Mixers with rotary stirring devices in fixed receptacles; Kneaders characterised by the orientation or disposition of the rotor axis with two or more rotation axes
- B01F27/2322—Mixers with rotary stirring devices in fixed receptacles; Kneaders characterised by the orientation or disposition of the rotor axis with two or more rotation axes with parallel axes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/23—Mixers with rotary stirring devices in fixed receptacles; Kneaders characterised by the orientation or disposition of the rotor axis
- B01F27/232—Mixers with rotary stirring devices in fixed receptacles; Kneaders characterised by the orientation or disposition of the rotor axis with two or more rotation axes
- B01F27/2324—Mixers with rotary stirring devices in fixed receptacles; Kneaders characterised by the orientation or disposition of the rotor axis with two or more rotation axes planetary
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T137/00—Fluid handling
- Y10T137/8593—Systems
- Y10T137/85978—With pump
- Y10T137/86035—Combined with fluid receiver
Definitions
- the present invention relates to mixing apparatus and to methods of mixing.
- Mixing apparatus for high viscosity mixtures must be adapted to provide sufficient shear force to continue moving against great resistance. In some cases, the resistance increases during mixing because the viscosity of the mixture increases.
- One example of a case where the viscosity of the mixture increases during mixing is preparation of a polymer/monomer mixture.
- a polymerization reaction begins.
- the polymerization reaction increases the average polymer chain length in the mixture and/or causes cross-linking between polymer chains. Increased polymer chain length and/or cross linking between polymer chains contribute to increased viscosity
- Polymerization mixtures are often employed in formulation of bone cement.
- One common polymer/monomer pair employed in bone cement formulation is polymethylmethacrylate/methylmethacrylate (PMMA/MMA).
- PMMA/MMA bone cements typically set to a solid form
- reaction conditions for the polymerization reaction are generally adjusted so that mixing PMMA and MMA produces a liquid phase which lasts several minutes. This is typically achieved by mixing a monomer liquid including MMA and, optionally DMPT and/or HQ, with a polymer powder including PMMA and, optionally Barium Sulfate and/or BPO and/or styrene.
- previously available mixing equipment is constructed for use with a liquid polymerization mixture and is not well suited to mixing of highly viscous cements that have substantially no liquid phase during mixing.
- U.S. Pat. No. 5,549,381 discloses a wiper which removes adhering mixture from a ribbon configuration mixing element as the mixing element is removed from the mixing apparatus. The disclosure of this patent is fully incorporated herein by reference.
- a broad aspect of some embodiments of the present invention relates to mixing of highly viscous materials in small batches.
- “highly viscous” indicates a viscosity of 500, 700 or 900 Pascal/second or lesser or greater or intermediate viscosities.
- Exemplary means of determining viscosity are set forth in Krause et al. (1982) “The viscosity of acrylic bone cements”, Journal of Biomedical Materials Research, 16:219-243) which is fully incorporated herein by reference.
- this viscosity is achieved within 30, 60, or 90 seconds of onset of mixing. However, under some circumstances the mixing may take a longer time.
- a small batch may be 100, 50, 25, 15 or 5 ml or lesser or intermediate volumes at the completion of mixing.
- the highly viscous material is a bone filler or “bone cement”.
- the bone cement includes a polymeric material, for example polymethylmethacrylate (PMMA).
- PMMA polymethylmethacrylate
- the bone cement is of a type described in one or more of U.S. patent applications U.S. 60/738,556; U.S. 60/762,789; 60/765,484 and Ser. No. 11/360,251. The disclosures of these applications are fully incorporated herein by reference.
- An aspect of some embodiments of the present invention relates to a mixer for a small batch of a highly viscous material including a drive mechanism employing a stationary circumferential gear on an inner surface of a mixing well.
- the stationary circumferential gear drives a planetary mixing element.
- the planetary mixing element travels circumferentially around the mixing well while rotating with respect to its own axis.
- the planetary mixing element mixes the material in conjunction with a central mixing element.
- the central mixing element is positioned substantially in a center of a mixing well.
- the central mixing element and/or the planetary mixing element rotate on their own axes.
- rotation of the planetary mixing element and the central mixing element is characterized by different radial velocities with respect to their respective axes.
- rotation of the planetary mixing element and the central mixing element is in opposite directions on their respective axes.
- An aspect of some embodiments of the present invention relates to a mixer for a small batch of viscous material including at least one planetary mixing element which revolves around a central mixing element deployed substantially at a center of the mixing well, wherein a distance (d) between outer surfaces of the mixing elements and between the planetary mixing element and an inner wall of the mixing well is substantially equivalent.
- An aspect of some embodiments of the present invention relates to a mixer for a small batch of viscous material characterized by a gear ratio between a stationary circumferential gear and a gear of a planetary mixing element selected to produce a desired shearing force on a mixture.
- An aspect of some embodiments of the present invention relates to a mixer for a small batch of viscous material characterized by mixing elements of a size selected to produce a desired shearing force on a mixture.
- the selected gear ratio increases as (d) increases. In an exemplary embodiment of the invention, for a desired shear force, the selected gear ratio increases as a diameter of a mixing well increases.
- An aspect of some embodiments of the present invention relates to a method of mixing components of a small batch of a mixture with a viscosity of at least 500 Pascal/second including operating a manual drive mechanism to cause a planetary mixing element to rotate about its own axis and to revolve around a central mixing element.
- An aspect of some embodiments of the present invention relates to use of a wiping element to automatically separate a viscous material from at least one mixing element of a mixing apparatus as the mixing element is removed from the apparatus so that the viscous material is retained in the apparatus.
- the wiping element includes at least one wiping aperture which substantially conforms to a mixing element.
- the wiping aperture is round, optionally substantially circular.
- the wiping element revolves within the mixing well during operation of the drive mechanism.
- An aspect of some embodiments of the present invention relates to an apparatus for transferring a viscous material from a first container to a second container.
- the apparatus is adapted for use with bone cement.
- the first container is a mixing well and the second container is a portion of an injection apparatus.
- manual manipulation of components of the apparatus produces sufficient force to cause a material characterized by a viscosity of 500 Pascal/sec to flow through an aperture between the first container and the second container.
- a desired shear force for a small batch of viscous material may be produced by varying one or more of:
- Relative velocities are optionally influenced by one or more of, dimensions, gear ratio, drive speed and rotation velocity of mixing elements.
- a mixing apparatus the apparatus includes:
- a drive mechanism including a stationary circumferential gear on an inner surface of the mixing well
- the drive mechanism is adapted to provide sufficient shear force to mix a mixture characterized by a viscosity of at least 500 Pascal/second.
- the viscosity of at least 500 Pascal/second is achieved within 90 seconds of an onset of mixing.
- the apparatus includes:
- the cover includes a locking ring.
- the drive mechanism is adapted for manual operation.
- the apparatus includes:
- a wiping element adapted to concurrently engage an inner surface of the mixing well and the planetary mixing element.
- the apparatus includes:
- the apparatus includes:
- a wiping element adapted to concurrently engage an inner surface of the mixing well, the planetary mixing element and the central mixing element.
- the central mixing element rotates about its own axis.
- the central mixing element and the planetary mixing element rotate in opposite directions.
- a mixing apparatus the apparatus includes:
- a wiping element adapted to engage an inner surface of the mixing well and including at least one wiping aperture substantially conforming to the at least one mixing element
- the wiping element does not interfere with operation of the drive mechanism
- the withdrawal of the at least one mixing element from the mixing well causes the at least one wiping aperture to remove at least a portion of the mixture from the at least one mixing element.
- the wiping element rotates within the mixing well while engaging an inner surface thereof.
- the drive mechanism is adapted to provide sufficient shear force to mix a mixture characterized by a viscosity of at least 500 Pascal/second.
- the apparatus includes:
- the cover includes a locking ring.
- the viscosity of at least 500 Pascal/second is achieved within 90 seconds of an onset of mixing.
- the wiping element is adapted to remove an adherent portion of a mixture characterized by a viscosity of at least 500 Pascal/second from the at least one mixing element.
- the at least one mixing element includes at least two mixing elements.
- the drive mechanism is adapted for manual operation.
- a mixing apparatus the apparatus includes:
- a first distance (d 1 ) between the central mixing element and the planetary mixing element is substantially equivalent to a second distance (d 2 ) between the planetary mixing element and an inner surface of the mixing well.
- the drive mechanism is adapted for manual operation.
- the drive mechanism is adapted to provide sufficient shear force to mix a mixture characterized by a viscosity of at least 500 Pascal/second.
- a drive mechanism for a mixing apparatus the drive mechanism includes;
- a toothed wheel characterized by an axis, the wheel adapted to engage said set of teeth and to rotate about the axis;
- an actuator adapted to provide a force which causes the toothed wheel to advance along the circular path.
- the mechanism includes
- provision of a force through the actuator causes the drive transfer element to rotate the second wheel about an axis through the center of the circular path.
- the toothed wheel drives a planetary mixing element.
- the second wheel drives a central mixing element.
- the actuator is manually powered.
- the mechanism is adapted to provide sufficient shear force to mix a mixture characterized by a viscosity of at least 500 Pascal/second.
- a method of mixing components of a viscous mixture includes:
- the method includes:
- the drive mechanism is adapted to provide sufficient shear force to mix a mixture characterized by a viscosity of at least 500 Pascal/second.
- the viscosity of at least 500 Pascal/second is achieved within 90 seconds of an onset of mixing.
- the manual drive mechanism supplies a sufficient force to cause the planetary mixing element to move through a mixture characterized by a viscosity of at least 500 Pascal-second.
- an apparatus for transferring a viscous material the apparatus includes:
- the apparatus is adapted to provide sufficient force to cause a viscous material characterized by a viscosity of at least 500 Pascal/second to flow through the aperture of the second container.
- the apparatus is configured so that manual manipulation of the first container and the transfer piston produces the sufficient force.
- the transfer piston is adapted to remove at least a portion of the viscous material from a mixing element as the mixing element is removed from the first container.
- a method of mixing components of a viscous mixture includes:
- the method includes driving a planetary mixing element by means of the drive mechanism.
- FIG. 1 is a simplified flow diagram illustrating an exemplary sequence of events associated with use of a mixing apparatus according to exemplary embodiments of the invention
- FIG. 2 is a perspective view of an exemplary mixing apparatus with the mixing elements removed from the mixing well;
- FIG. 3 partial cut away view of assembled mixer showing portion of an exemplary drive mechanism
- FIGS. 4A and 4B are a schematic representation and an engineering projection showing rotation direction and distances for an exemplary drive mechanism respectively;
- FIG. 5 is a diagram illustrating shear stress gradients between a planetary mixing element and a central mixing element according to exemplary embodiments of the invention
- FIGS. 6 , 7 and 8 illustrate an exemplary wiping element adapted for use with an exemplary mixing apparatus
- FIGS. 9 and 10 illustrate a transfer module adapted for use with exemplary mixing apparatus.
- Previously available bone cement formulations were characterized by a relatively long liquid phase and a short working window during which the cement was suitable for injection.
- a new class of cement formulations, disclosed in the inventor's previous applications is characterized by a rapid transition to a high viscosity without a persistent liquid phase followed by a relatively long working window before the cement sets to solidity.
- the almost immediate transition to high viscosity of the new class of cement formulations disclosed in the inventor's previous applications means that high shear forces are desirable in order to assure complete mixing.
- bone cement is typically prepared in small batches (e.g. 5, 10, 20, 30, 40, 50 ml or lesser or greater or intermediate volumes), these new cement formulations of the inventor's previous applications impose new constraints on bone cement mixing apparatus.
- Exemplary mixing apparatus according to the present invention may also be employed with conventional bone cement formulations.
- exemplary mixing apparatus according to the present invention may be employed after the polymerization reaction has progressed past the liquid phase and achieved a viscosity of 400, optionally 500 Pascal/second or lesser or greater or intermediate viscosity.
- exemplary mixing apparatus according to the present invention may be employed to mix a liquid mixture by adjusting a distance between the mixing elements.
- exemplary mixing apparatus according to the present invention may be employed to mix a cement prepared according to a previously known formulation after the mixture reaches viscosity of at least 100 Pascal/second.
- FIG. 1 is a simplified flow diagram illustrating sequence of acts associated with performance of a method 100 according to exemplary embodiments of the invention.
- At 110 components are placed into a mixing well or mixing well of a mixing apparatus.
- this operation may be performed as part of a manufacturing procedure of apparatus 200 .
- one or more wiping elements are deployed 120 .
- Deployment may be in the mixing well or on a cover and/or on mixing elements of the mixing apparatus and may occur before or after components are placed 110 in the mixing well.
- mixing elements are inserted into the mixing well so that they are at least partially submerged in components of the mixture. If a wiping element has been deployed 120 , the components of the mixture are generally below the wiping element at this stage.
- a drive mechanism is operated to mix 140 the components.
- mixing 140 will cause the components to form a high viscosity mixture in a relatively short period of time, optionally in a few seconds.
- satisfactory preparation of bone cement is achieved by continuing mixing 140 after the high viscosity mixture has been formed.
- operation of the drive mechanism is manual and/or driven by a motor or by compressed air or by any other external source of force known in the art.
- mixing elements 150 are removed. If a wiping element has been deployed 120 , automatic wiping 152 of the mixing elements occurs at this stage. Optionally, the wiping element remains in the mixing well during and/or after withdrawal 150 .
- cement is transferred 160 from the mixing well to an injection reservoir directly.
- transfer 160 is accomplished using transfer apparatus which comprises an exemplary embodiment of the invention.
- FIGS. 2 , 3 , 6 , 7 and 8 depict an exemplary embodiment of a mixing apparatus 200 according to the present invention
- FIG. 2 shows an exemplary apparatus 200 with a cover 220 removed from a base 250 .
- Cover 220 is depicted with an optional locking ring 224 which mates to a set of threads 256 on base 250 .
- components are placed 110 in a mixing well 252 at this stage.
- components are placed 110 in mixing well 252 as part of a manufacturing and assembly process.
- apparatus 200 is supplied assembled as depicted in FIG. 3 .
- undesired premature mixing of monomer liquid and polymer powder may be prevented by a variety of methods. Exemplary methods of preventing undesired premature mixing are described below.
- Cover 220 includes portions of a drive mechanism.
- the drive mechanism is optionally a manual mechanism operable by a handle 210 .
- cover 220 includes a downward facing protrusion 222 ( FIG. 6 ) configured to engage a wiping element 260 by means of engagement arms 262 .
- engagement arms 262 B function primarily to engage protrusion 222 .
- engagement arms 262 A function to engage protrusion 222 and to engage a groove 264 in base 250 .
- a relationship between engagement arms 262 A and groove 264 in base 250 is described below.
- a central mixing element 230 and a planetary mixing element 240 are visible protruding downwards from cover 220 .
- two or more planetary mixing elements 240 are provided.
- a portion of a planetary drive gear 270 is also visible in this view.
- Base 250 includes an inner mixing well 252 and a series of inward facing teeth which function as a stationary circumferential gear 254 .
- Stationary circumferential gear 254 is a part of the drive mechanism and is configured to engage planetary drive gear 270 when cover 220 is assembled with base 250 .
- FIG. 3 is a partial cut-away view of assembled apparatus 200 illustrating the drive mechanism in greater detail.
- Mixing elements 230 and 240 are inserted 130 in this view and optional wiping element 120 has been deployed in the pictured embodiment.
- Planetary drive gear 270 is positioned above a center axis of planetary mixing element 240 and connected thereto so that mixing element 240 travels and/or rotates together with gear 270 .
- Gear 270 is coupled to cover 220 by drive shaft 272 seated in drive shaft receptacle 274 of cover 220 .
- Teeth of planetary gear 270 engage complementary teeth of stationary circumferential gear 254 in mixing well 252 of base 250 .
- Planetary mixing element 240 is coupled to central mixing element 230 by drive element 232 .
- Wiping element 260 concurrently engages an inner surface of mixing well 252 and mixing elements 230 and 240 .
- drive mechanism for example by rotation of handle 210 , causes cover 220 to rotate with respect to base 250 .
- This causes planetary drive shaft 272 to advance on a circular path concentric to an inner wall of mixing well 252 .
- Planetary gear 270 engages stationary circumferential gear 254 so that planetary gear 270 rotates planetary mixing element 240 as planetary drive shaft 272 and planetary mixing element 240 advance along their circular path.
- drive element 232 is coupled to both planetary mixing element 240 and central mixing element 230 .
- drive element 232 causes central mixing element 230 to rotate as planetary mixing element 240 advances. In other embodiments of the invention, central mixing element 230 does not rotate. As mixing element 240 advances, mixing 140 occurs.
- FIG. 4A is a schematic representation of an exemplary drive mechanism viewed from above base 250 .
- the physical relationship between planetary gear 270 , planetary drive shaft 272 , central mixing element 230 , stationary circumferential gear 254 and drive element 232 (pictured here as a lever) is more clearly visible in this view than in the preceding figure. Engineering considerations of the drive mechanism are discussed below.
- stationary circumferential gear 254 has 3 times as many teeth as planetary drive gear 270 .
- Mixing elements 230 and 240 are optionally roughened, serrated or striated to insure formation of a boundary layer in the material being mixed in proximity to a surface of the mixing elements during mixing.
- an inner surface of well 252 is similarly roughened, serrated or striated to insure formation of a boundary layer in proximity to a surface of the well.
- serrations in the form of vertical slits that extend along the full height of mixing elements 230 and/or 240 .
- the longitudinal slits contribute to easy introduction and removal of mixing elements 230 and/or 240 through wiping apertures in wiping element 260 .
- vertical slits are characterized by a depth of 0.1, 0.5 or 1 mm or lesser or greater or intermediate depths.
- FIG. 4B is an engineering projection showing rotation directions and distances for an exemplary drive mechanism respectively; The view is looking down on base 250 as for FIG. 4A .
- V ( A ) ⁇ 1* R 1
- V ( B ) ⁇ 1* R ( B )+ ⁇ 2* R 2
- V ( C ) ⁇ 1* R ( C ) ⁇ i* ⁇ 1* R 2
- V ( B ) ⁇ V ( A ) ⁇ 1*( R ( B ) ⁇ R 1+ iR 2)
- apparatus 200 is operated manually, so ⁇ 1 is set by the operator.
- ⁇ 1 can be 10, 15, 22, or 30 RPM or lesser or greater or intermediate values.
- R1, R2, R(B), R(C) and i are selected to meet both geometry considerations and relatively similar velocity gradients that are sufficient to produce adequate shear stresses in consideration of a selected viscosity, such as, for example, 500 Pascal/second.
- FIG. 5 illustrates a theoretic gradient of the shear stress applied to a mixture 500 flowing between a two elements (e.g. planetary mixing element 240 and central mixing element 230 or planetary mixing element 240 and an inner wall of mixing well 254 ). As the viscosity of mixture 500 increases, the shear stress necessary for mixing also increases.
- a two elements e.g. planetary mixing element 240 and central mixing element 230 or planetary mixing element 240 and an inner wall of mixing well 254 .
- sufficient shear force to mix a mixture 500 characterized by a viscosity of 500 Pascal/second is provided by adjusting distance between the two mixing elements (A to B in FIG. 4B ) or between planetary mixing element 240 and an inner wall of mixing well 254 (C to D in FIG. 4B ) to 1 to 5 mm, optionally about 2 mm.
- shear force may be adjusted by varying the surface area of mixing elements 230 and/or 240 and/or an inner surface of well 252 which contacts the mixture.
- FIGS. 6 , 7 and 8 illustrate placement and function of optional wiping element 260 according to an exemplary embodiment of the invention.
- FIG. 6 illustrates wiping element 260 engaging downward facing protrusion 222 by means of engagement arms 262 A and 262 B. Circumferential groove 264 of mixing well 252 is empty at this stage. Mixing elements 230 and 240 protrude through wiping apertures in wiping element 260 .
- FIG. 7 illustrates cover 220 assembled on base 250 so that wiping elements 230 and 240 are in close proximity to floor 258 of mixing well 252 .
- Engagement arms 262 of wiping element 260 are seated in groove 264 of mixing well 252 (magnified in inset for clarity). Each of engagement arms 262 slides circumferentially around mixing well 252 in groove 264 as planetary mixing element 240 travels around mixing well 252 .
- FIG. 8 illustrates removal 150 of mixing elements 230 and 240 from mixing well 252 .
- Engagement arms 262 are retained by groove 264 so that wiping element is locked into position. Removal of elements 230 and 240 results in automatic wiping 152 by the edges of the wiping apertures.
- FIGS. 9 and 10 illustrate a transfer mechanism according to exemplary embodiments of the invention as previously disclosed in co-pending U.S. application Ser. No. 11/360,251, the disclosure of which is fully incorporated herein by reference.
- FIG. 9 is a cross-sectional view and
- FIG. 10 is a partial cut-away view in perspective.
- FIGS. 9 and 10 illustrate an exemplary transfer element 900 including a transfer piston cup 950 inserted in mixing well 254 .
- threads 956 of piston cup 950 engage threads 256 of base 250 .
- floor 958 of transfer piston cup 950 is forced downwards and towards floor 258 of mixing well 252 .
- This action applies downward pressure on wiping element 260 .
- the downward pressure causes engagement arms 262 to be released from groove 264 .
- wiping element 260 is free to travel downwards towards floor 258 of mixing well 252 .
- wiping element 260 also serves also as a piston which pushes the mixture into injection reservoir 910 .
- transfer piston cup 950 is fitted with a second set of threads 952 which engage matching threads 930 on injection reservoir 910 .
- injection reservoir 910 is attached to transfer piston cup 950 by threads 930 and 952 before transfer piston cup 950 is inserted into mixing well 252 .
- contents of mixing well 252 e.g. high viscosity bone cement
- Injection nozzle 920 serves to release air from injection reservoir 910 so that no resistive pressure accumulates.
- the mixed material has been transferred 160 to the injector at this stage.
- an operator of the apparatus knows that reservoir 910 is full when bone cement exits injection nozzle 920 .
- an inner volume of the mixing well 252 is 5, optionally 10, optionally 20, optionally 40, optionally 60, optionally 80, optionally 100 ml or lesser or greater or intermediate volumes.
- the mixing well volume is 50 to 60 ml, optionally about 66 ml, and 10 to 20 ml of mixture, optionally about 15 ml of mixture is placed in the chamber for mixing.
- a portion of the inner volume of well 252 is occupied by mixing elements 230 and 240 .
- an inner diameter of the mixing well is 20, optionally 40, optionally 60, optionally 80, optionally 100 mm or lesser or greater or intermediate sizes.
- the inner diameter of the mixing well is 40 to 50 mm, optionally about 46 mm.
- a height of the mixing well is 20, although it can be 40, 60, 80, or 100 mm or lesser or greater or intermediate sizes. In an exemplary embodiment of the invention, the height of the mixing well is 35 to 45 mm, optionally about 40 mm.
- an aspect ratio (diameter/height) of the mixing well is 0.7, 0.9, 1.1, or 1.3, or lesser or greater or intermediate values.
- aspect ratio (diameter/height) of the mixing well is 1.1 to 1.2, optionally about 1.15.
- a distance (d 1 ) between the central mixing element and the planetary mixing element (indicated by A to B in FIG. 4A ) and/or a distance (d 2 ) between the planetary mixing element and an inner wall of the mixing well (indicated by C to D in FIG. 4A ) is 1, 2, 3, 4, or 5 mm or lesser or greater or intermediate distances.
- d 1 is substantially equivalent to d 2 .
- a volume of approximately 5 ml is injected in a single vertebra. It is common to prepare a batch of approximately 8 ml of cement if a single vertebra is to be injected, approximately 15 ml of cement if two vertebrae are to be injected and progressively larger volumes if three or more vertebrae are to be injected. Combination of powdered polymer component and liquid monomer component leads to a reduction in total mixture volume as the polymer is wetted by the monomer. For example, 40 to 50 ml of polymer powder may be mixed 112 with 7 to 9 ml of monomer liquid to produce 18 ml of polymerized cement. In an exemplary embodiment of the invention, a volume of well 252 is selected to accommodate the large initial column of monomer powder, even when a significantly smaller batch of cement is being prepared.
- a dead volume of cement remaining in well 242 after transfer to injection reservoir 910 by transfer element 900 is less than 2, 1, or 0.5 ml or lesser or intermediate values.
- a diameter of central mixing element 230 and a diameter of injection reservoir 910 are both equivalent to a diameter of an aperture in wiping element 260 .
- this conformity of diameters reduces a dead volume of cement left in well 252 after operation of transfer apparatus 900 .
- the diameters are all approximately 18 mm.
- mixing well 252 of base 250 is transferred to an injection apparatus and cement is injected into a subject directly from well 252 .
- component parts of the mixing apparatus are constructed of Polyamides (e.g., Nylon) and/or Polypropylene.
- some portions of the apparatus are constructed of a metal, for example stainless steel.
- metal is employed to construct parts which are subject to large forces, such as friction or torque.
- one or more of handle 210 , gears (e.g. 270 ), teeth (e.g. 254 ), drive arms (e.g. 232 ) and mixing elements (e.g. 230 and/or 240 ) are constructed of metal.
- apparatus 200 is provided with instructions for use.
- the instructions indicate a procedure for achieving complete mixing of a mixture placed in well 252 .
- these instructions indicate an amount of time recommended to insure complete mixing.
- the time is 30 to 90 seconds, optionally 30 to 60 seconds, optionally about 45 seconds or lesser or greater or intermediate amounts of time.
- these instructions indicate a number of turns recommended to insure complete mixing.
- the number of turns is 20 to 100, optionally 40 to 60, optionally about 50 or a lesser or greater or intermediate number.
- these instructions indicate a signal which will be presented to the user when mixing is complete.
- the signal may be a visual signal (e.g. indicator light) or an audible signal (e.g. buzzer or bell) or a tactile signal (e.g. gear 270 slips on teeth 254 when a desired viscosity is reached).
- the signal is triggered by a closed feedback loop.
- the loop may rely upon, for example, an indirect measure of viscosity (e.g. torque), centripetal force, time, number of revolutions of a portion of apparatus 200 (e.g. handle 210 , gear 270 or mixing element 230 and/or 240 ) or mixture volume.
- the apparatus combines a mechanism that allow turning of handle only during a preset window of time and/or number of rotations.
- Shear force on a mixture within well 252 is affected primarily by surface properties, distance between surfaces, and differences in velocities between surfaces.
- Distances between surfaces are inversely related to shear forces acting on a mixture 500 moving between the surfaces.
- an applied shear force to a portion of mixture 500 crossing those lines decreases.
- Differences in relative velocities between portions of mixer 200 also affect shear forces on mixture 200 . As the difference in relative velocities increases, the applied shear force to a portion of mixture 500 flowing between the elements increases.
- the relative velocities are optionally influenced by angular velocities and/or radial velocities and/or radius of the elements involved as discussed in more detail above. In an exemplary embodiment of the invention, differences in relative velocity are amplified by imparting angular velocities with different directions to mixing elements 240 and 230 .
- some exemplary embodiments of the invention include safety features to reduce exposure to undesired vapors.
- locking ring 224 is equipped with an air-tight seal (e.g. rubber or silicon) which prevents vapors from escaping from well 252 .
- an air-tight seal e.g. rubber or silicon
- apparatus 200 may be provided with an evacuation port (not shown) connectable to a vacuum source.
- the vacuum source is a standard “wall suction” unit in a hospital operating room and the undesired vapors are from an MMA component of a bone cement mixture.
- One exemplary method of preventing undesired premature mixing of monomer liquid and polymer powder is to provide the monomer liquid in a sealed bag or capsule which is burst when apparatus 200 is operated.
- the capsule may be burst when it is drawn across line A-B or C-D by the flow of mixture 500 .
- the capsule is designed so that it is characterized by a smallest dimension which exceeds the length of A-B and/or C-D.
- the bag or capsule is constructed of a biocompatible material which may be injected together with the bone cement.
- Another exemplary method of preventing undesired premature mixing of monomer liquid and polymer powder is to provide the monomer liquid inside central mixing element 230 .
- partial removal of cover 220 from base 250 permits the monomer liquid to exit mixing element 230 into well 252 .
- tightening of locking ring 224 breaks a seal in mixing element 230 . Breaking the seal releases the liquid monomer onto the powder component.
- Another exemplary method of preventing undesired premature mixing of monomer liquid and polymer powder is to provide the monomer liquid in a cavity inside a wall of mixing well 252 .
- contents of the cavity are dumped into well 252 manually or automatically when mixing commences.
- each of the verbs “comprise”, “include” and “have” as well as any conjugates thereof, are used to indicate that the object or objects of the verb are not necessarily a complete listing of members, components, elements or parts of the subject or subjects of the verb.
Abstract
Description
- The present application claims the benefit under 119(e) of U.S. provisional patent applications U.S. 60/738,556, filed on Nov. 22, 2005, U.S. 60/762,789, filed on Jan. 26, 2006; and U.S. 60/765,484, filed on Feb. 2, 2006 all of which are entitled “METHODS, MATERIALS AND APPARATUS FOR TREATING BONE AND OTHER TISSUE”.
- The present application is also a continuation in part of U.S. patent application Ser. No. 11/360,251 entitled “METHODS, MATERIALS AND APPARATUS FOR TREATING BONE AND OTHER TISSUE”, filed on Feb. 22, 2006.
- The present invention relates to mixing apparatus and to methods of mixing.
- Mechanical mixers for mixing components to homogeneity are well known. Their applications include, but are not limited to, baking, building construction and medicine.
- Mixing apparatus for high viscosity mixtures must be adapted to provide sufficient shear force to continue moving against great resistance. In some cases, the resistance increases during mixing because the viscosity of the mixture increases.
- One example of a case where the viscosity of the mixture increases during mixing is preparation of a polymer/monomer mixture. When a polymer and monomer are combined, a polymerization reaction begins. The polymerization reaction increases the average polymer chain length in the mixture and/or causes cross-linking between polymer chains. Increased polymer chain length and/or cross linking between polymer chains contribute to increased viscosity
- Polymerization mixtures are often employed in formulation of bone cement. One common polymer/monomer pair employed in bone cement formulation is polymethylmethacrylate/methylmethacrylate (PMMA/MMA). Because PMMA/MMA bone cements typically set to a solid form, reaction conditions for the polymerization reaction are generally adjusted so that mixing PMMA and MMA produces a liquid phase which lasts several minutes. This is typically achieved by mixing a monomer liquid including MMA and, optionally DMPT and/or HQ, with a polymer powder including PMMA and, optionally Barium Sulfate and/or BPO and/or styrene. As a result, previously available mixing equipment is constructed for use with a liquid polymerization mixture and is not well suited to mixing of highly viscous cements that have substantially no liquid phase during mixing.
- The following references are cited as being generally indicative of mixer types which are currently available for use in preparation of bone cement. The list does not purport to be exhaustive.
- U.S. Pat. No. 5,302,020; US 2003/0174576; U.S. Pat. No. 6,994,465 and U.S. Pat. No. 4,961,647 disclose use of a central mixing element in combination with a planetary mixing element which revolves around the central mixing element. The disclosure of each of these patents is fully incorporated herein by reference.
- U.S. Pat. No. 5,415,474 and U.S. Pat. No. 7,029,163 disclose a transfer mechanism as part of a mixing apparatus. The disclosure of each of these patents is fully incorporated herein by reference.
- U.S. Pat. No. 5,549,381 discloses a wiper which removes adhering mixture from a ribbon configuration mixing element as the mixing element is removed from the mixing apparatus. The disclosure of this patent is fully incorporated herein by reference.
- A broad aspect of some embodiments of the present invention relates to mixing of highly viscous materials in small batches. In an exemplary embodiment of the invention, “highly viscous” indicates a viscosity of 500, 700 or 900 Pascal/second or lesser or greater or intermediate viscosities. Exemplary means of determining viscosity are set forth in Krause et al. (1982) “The viscosity of acrylic bone cements”, Journal of Biomedical Materials Research, 16:219-243) which is fully incorporated herein by reference. Optionally, this viscosity is achieved within 30, 60, or 90 seconds of onset of mixing. However, under some circumstances the mixing may take a longer time. A small batch may be 100, 50, 25, 15 or 5 ml or lesser or intermediate volumes at the completion of mixing.
- In an exemplary embodiment of the invention, the highly viscous material is a bone filler or “bone cement”. Optionally, the bone cement includes a polymeric material, for example polymethylmethacrylate (PMMA). Optionally, the bone cement is of a type described in one or more of U.S. patent applications U.S. 60/738,556; U.S. 60/762,789; 60/765,484 and Ser. No. 11/360,251. The disclosures of these applications are fully incorporated herein by reference.
- An aspect of some embodiments of the present invention relates to a mixer for a small batch of a highly viscous material including a drive mechanism employing a stationary circumferential gear on an inner surface of a mixing well. In an exemplary embodiment of the invention, the stationary circumferential gear drives a planetary mixing element. The planetary mixing element travels circumferentially around the mixing well while rotating with respect to its own axis.
- In an exemplary embodiment of the invention, the planetary mixing element mixes the material in conjunction with a central mixing element. In an exemplary embodiment of the invention, the central mixing element is positioned substantially in a center of a mixing well. Optionally, the central mixing element and/or the planetary mixing element rotate on their own axes.
- In an exemplary embodiment of the invention, rotation of the planetary mixing element and the central mixing element is characterized by different radial velocities with respect to their respective axes.
- In an exemplary embodiment of the invention, rotation of the planetary mixing element and the central mixing element is in opposite directions on their respective axes.
- An aspect of some embodiments of the present invention relates to a mixer for a small batch of viscous material including at least one planetary mixing element which revolves around a central mixing element deployed substantially at a center of the mixing well, wherein a distance (d) between outer surfaces of the mixing elements and between the planetary mixing element and an inner wall of the mixing well is substantially equivalent.
- An aspect of some embodiments of the present invention relates to a mixer for a small batch of viscous material characterized by a gear ratio between a stationary circumferential gear and a gear of a planetary mixing element selected to produce a desired shearing force on a mixture.
- An aspect of some embodiments of the present invention relates to a mixer for a small batch of viscous material characterized by mixing elements of a size selected to produce a desired shearing force on a mixture.
- In an exemplary embodiment of the invention, for a desired shear force, the selected gear ratio increases as (d) increases. In an exemplary embodiment of the invention, for a desired shear force, the selected gear ratio increases as a diameter of a mixing well increases.
- An aspect of some embodiments of the present invention relates to a method of mixing components of a small batch of a mixture with a viscosity of at least 500 Pascal/second including operating a manual drive mechanism to cause a planetary mixing element to rotate about its own axis and to revolve around a central mixing element.
- An aspect of some embodiments of the present invention relates to use of a wiping element to automatically separate a viscous material from at least one mixing element of a mixing apparatus as the mixing element is removed from the apparatus so that the viscous material is retained in the apparatus. In an exemplary embodiment of the invention, the wiping element includes at least one wiping aperture which substantially conforms to a mixing element. Optionally, the wiping aperture is round, optionally substantially circular. In an exemplary embodiment of the invention, the wiping element revolves within the mixing well during operation of the drive mechanism.
- An aspect of some embodiments of the present invention relates to an apparatus for transferring a viscous material from a first container to a second container. In an exemplary embodiment of the invention, the apparatus is adapted for use with bone cement. Optionally, the first container is a mixing well and the second container is a portion of an injection apparatus. In an exemplary embodiment of the invention, manual manipulation of components of the apparatus produces sufficient force to cause a material characterized by a viscosity of 500 Pascal/sec to flow through an aperture between the first container and the second container.
- According to various embodiments of the invention, a desired shear force for a small batch of viscous material may be produced by varying one or more of:
- a) roughness of surfaces in a mixing well and/or on mixing elements, to create a boundary layer;
- b) distances between the surfaces, wherein smaller distances contribute to increased shear force;
- c) relative velocities of surfaces of mixing elements and/or surface of the mixing well.
- Relative velocities are optionally influenced by one or more of, dimensions, gear ratio, drive speed and rotation velocity of mixing elements.
- In an exemplary embodiment of the invention, there is provided a mixing apparatus, the apparatus includes:
- a) a mixing well characterized by an internal volume not exceeding 100 ml.;
- b) a drive mechanism including a stationary circumferential gear on an inner surface of the mixing well; and
- c) a planetary mixing element driven by a mixing element gear which engages the stationary circumferential gear.
- Optionally, the drive mechanism is adapted to provide sufficient shear force to mix a mixture characterized by a viscosity of at least 500 Pascal/second.
- Optionally, the viscosity of at least 500 Pascal/second is achieved within 90 seconds of an onset of mixing.
- Optionally, the apparatus includes:
- d) a cover engageable by the mixing well and adapted for closure thereof.
- Optionally, the cover includes a locking ring.
- Optionally, the drive mechanism is adapted for manual operation.
- Optionally, the apparatus includes:
- d) a wiping element adapted to concurrently engage an inner surface of the mixing well and the planetary mixing element.
- Optionally, the apparatus includes:
- d) a central mixing element positioned substantially at a center of the mixing well.
- Optionally, the apparatus includes:
- e) a wiping element adapted to concurrently engage an inner surface of the mixing well, the planetary mixing element and the central mixing element.
- Optionally, the central mixing element rotates about its own axis.
- Optionally, the central mixing element and the planetary mixing element rotate in opposite directions.
- In an exemplary embodiment of the invention, there is provided a mixing apparatus, the apparatus includes:
- a) a mixing well characterized by an internal volume not exceeding 100 ml.;
- b) a drive mechanism adapted to operate at least one mixing element positioned in the mixing well; and
- c) a wiping element adapted to engage an inner surface of the mixing well and including at least one wiping aperture substantially conforming to the at least one mixing element;
- wherein the wiping element does not interfere with operation of the drive mechanism; and
- wherein the withdrawal of the at least one mixing element from the mixing well causes the at least one wiping aperture to remove at least a portion of the mixture from the at least one mixing element.
- Optionally, the wiping element rotates within the mixing well while engaging an inner surface thereof.
- Optionally, the drive mechanism is adapted to provide sufficient shear force to mix a mixture characterized by a viscosity of at least 500 Pascal/second.
- Optionally, the apparatus includes:
- d) a cover engageable by the mixing well and adapted for closure thereof.
- Optionally, the cover includes a locking ring.
- Optionally, the viscosity of at least 500 Pascal/second is achieved within 90 seconds of an onset of mixing.
- Optionally, the wiping element is adapted to remove an adherent portion of a mixture characterized by a viscosity of at least 500 Pascal/second from the at least one mixing element.
- Optionally, the at least one mixing element includes at least two mixing elements.
- Optionally, the drive mechanism is adapted for manual operation.
- In an exemplary embodiment of the invention, there is provided a mixing apparatus, the apparatus includes:
- a) a mixing well characterized by an internal volume not exceeding 100 ml.;
- b) a central mixing element deployed substantially at a center of the mixing well;
- c) at least one planetary mixing element which revolves around the central mixing element;
- wherein a first distance (d1) between the central mixing element and the planetary mixing element is substantially equivalent to a second distance (d2) between the planetary mixing element and an inner surface of the mixing well.
- Optionally, the drive mechanism is adapted for manual operation.
- Optionally, the drive mechanism is adapted to provide sufficient shear force to mix a mixture characterized by a viscosity of at least 500 Pascal/second.
- In an exemplary embodiment of the invention, there is provided a drive mechanism for a mixing apparatus, the drive mechanism includes;
- a) a set of teeth defining a circular path on an inner circumference of a vessel characterized by an internal volume not exceeding 100 ml;
- b) a toothed wheel characterized by an axis, the wheel adapted to engage said set of teeth and to rotate about the axis; and
- c) an actuator adapted to provide a force which causes the toothed wheel to advance along the circular path.
- Optionally, the mechanism includes
- d) a drive transfer element connecting between the axis of the toothed wheel and a second wheel positioned substantially at a center of the circular path.
- Optionally, provision of a force through the actuator causes the drive transfer element to rotate the second wheel about an axis through the center of the circular path.
- Optionally, the toothed wheel drives a planetary mixing element.
- Optionally, the second wheel drives a central mixing element.
- Optionally, the actuator is manually powered.
- Optionally, the mechanism is adapted to provide sufficient shear force to mix a mixture characterized by a viscosity of at least 500 Pascal/second.
- In an exemplary embodiment of the invention, there is provided a method of mixing components of a viscous mixture, the method includes:
- a) placing the components in a mixing well characterized by an inner volume of not more than 100 ml;
- b) deploying at least one planetary mixing element and a central mixing element in the mixing well; and
- c) operating a manual drive mechanism to cause the planetary mixing element to both rotate about its own axis and revolve around the central mixing element in order to mix the components to form a mixture.
- Optionally, the method includes:
- e) engaging a wiping element to at least one of the mixing elements such that withdrawal of the mixing element from the mixing well causes the wiping element to wipe mixture from the mixing element.
- Optionally, the drive mechanism is adapted to provide sufficient shear force to mix a mixture characterized by a viscosity of at least 500 Pascal/second.
- Optionally, the viscosity of at least 500 Pascal/second is achieved within 90 seconds of an onset of mixing.
- Optionally, the manual drive mechanism supplies a sufficient force to cause the planetary mixing element to move through a mixture characterized by a viscosity of at least 500 Pascal-second.
- In an exemplary embodiment of the invention, there is provided an apparatus for transferring a viscous material, the apparatus includes:
- a) a first container capable of containing a viscous material;
- b) a transfer piston insertable in the first container so that the piston forms a circumferential seal with respect to the container, the transfer piston including a hole; and
- c) a mechanism for attaching an aperture of a second container to the hole in the transfer piston;
- wherein insertion of the transfer piston into the first container causes the viscous material to pass through the aperture into the second container.
- Optionally, the apparatus is adapted to provide sufficient force to cause a viscous material characterized by a viscosity of at least 500 Pascal/second to flow through the aperture of the second container.
- Optionally, the apparatus is configured so that manual manipulation of the first container and the transfer piston produces the sufficient force.
- Optionally, the transfer piston is adapted to remove at least a portion of the viscous material from a mixing element as the mixing element is removed from the first container.
- In an exemplary embodiment of the invention, there is provided a method of mixing components of a viscous mixture, the method includes:
- a) placing the components in a mixing well characterized by an inner volume of not more than 100 ml;
- b) operating a drive mechanism to cause mixing of the material in the inner volume during a period when the viscosity is at least 500 Pascal/sec.
- Optionally, the method includes driving a planetary mixing element by means of the drive mechanism.
- Exemplary non-limiting embodiments of the invention described in the following description, read with reference to the figures attached hereto. In the figures, identical and similar structures, elements or parts thereof that appear in more than one figure are generally labeled with the same or similar references in the figures in which they appear. Dimensions of components and features shown in the figures are chosen primarily for convenience and clarity of presentation and are not necessarily to scale. The attached figures are:
-
FIG. 1 is a simplified flow diagram illustrating an exemplary sequence of events associated with use of a mixing apparatus according to exemplary embodiments of the invention; -
FIG. 2 is a perspective view of an exemplary mixing apparatus with the mixing elements removed from the mixing well; -
FIG. 3 partial cut away view of assembled mixer showing portion of an exemplary drive mechanism; -
FIGS. 4A and 4B are a schematic representation and an engineering projection showing rotation direction and distances for an exemplary drive mechanism respectively; -
FIG. 5 is a diagram illustrating shear stress gradients between a planetary mixing element and a central mixing element according to exemplary embodiments of the invention; -
FIGS. 6 , 7 and 8 illustrate an exemplary wiping element adapted for use with an exemplary mixing apparatus; and -
FIGS. 9 and 10 illustrate a transfer module adapted for use with exemplary mixing apparatus. - U.S. application 60/738,556; U.S. 60/762,789; U.S. 60/765,484; and Ser. No. 11/360,251 (hereinafter “the inventor's previous applications”), the disclosures of which are each fully incorporated herein by reference, disclose polymeric bone cement formulations which are characterized by a rapid transition to a high viscosity state. According to exemplary cement formulations disclosed in these applications, mixture of monomer and polymer components produces a mixture characterized by a viscosity in the range of 400 to 500 Pascal/second substantially as soon as the polymer is wetted by the monomer. In practice, this can take as little as 30 seconds.
- Previously available bone cement formulations were characterized by a relatively long liquid phase and a short working window during which the cement was suitable for injection. A new class of cement formulations, disclosed in the inventor's previous applications is characterized by a rapid transition to a high viscosity without a persistent liquid phase followed by a relatively long working window before the cement sets to solidity. The almost immediate transition to high viscosity of the new class of cement formulations disclosed in the inventor's previous applications means that high shear forces are desirable in order to assure complete mixing. For this new class of cement formulations, it is not feasible to mix components when the mixture is still in the liquid state because there is essentially no liquid state.
- Because bone cement is typically prepared in small batches (e.g. 5, 10, 20, 30, 40, 50 ml or lesser or greater or intermediate volumes), these new cement formulations of the inventor's previous applications impose new constraints on bone cement mixing apparatus.
- Exemplary mixing apparatus according to the present invention may also be employed with conventional bone cement formulations. Optionally, exemplary mixing apparatus according to the present invention may be employed after the polymerization reaction has progressed past the liquid phase and achieved a viscosity of 400, optionally 500 Pascal/second or lesser or greater or intermediate viscosity. Optionally, exemplary mixing apparatus according to the present invention may be employed to mix a liquid mixture by adjusting a distance between the mixing elements. Optionally, exemplary mixing apparatus according to the present invention may be employed to mix a cement prepared according to a previously known formulation after the mixture reaches viscosity of at least 100 Pascal/second.
-
FIG. 1 is a simplified flow diagram illustrating sequence of acts associated with performance of amethod 100 according to exemplary embodiments of the invention. - At 110 components are placed into a mixing well or mixing well of a mixing apparatus. Optionally this operation may be performed as part of a manufacturing procedure of
apparatus 200. - Optionally, one or more wiping elements are deployed 120. Deployment may be in the mixing well or on a cover and/or on mixing elements of the mixing apparatus and may occur before or after components are placed 110 in the mixing well.
- At 130 mixing elements are inserted into the mixing well so that they are at least partially submerged in components of the mixture. If a wiping element has been deployed 120, the components of the mixture are generally below the wiping element at this stage.
- A drive mechanism is operated to mix 140 the components. As described hereinabove, according to exemplary embodiments of the invention, mixing 140 will cause the components to form a high viscosity mixture in a relatively short period of time, optionally in a few seconds. In an exemplary embodiment of the invention, satisfactory preparation of bone cement is achieved by continuing mixing 140 after the high viscosity mixture has been formed. Optionally, operation of the drive mechanism is manual and/or driven by a motor or by compressed air or by any other external source of force known in the art.
- After mixing 140 is complete, mixing
elements 150 are removed. If a wiping element has been deployed 120, automatic wiping 152 of the mixing elements occurs at this stage. Optionally, the wiping element remains in the mixing well during and/or afterwithdrawal 150. - Optionally, cement is transferred 160 from the mixing well to an injection reservoir directly. Optionally,
transfer 160 is accomplished using transfer apparatus which comprises an exemplary embodiment of the invention. -
FIGS. 2 , 3, 6, 7 and 8 depict an exemplary embodiment of amixing apparatus 200 according to the present invention -
FIG. 2 shows anexemplary apparatus 200 with acover 220 removed from abase 250. Cover 220 is depicted with anoptional locking ring 224 which mates to a set ofthreads 256 onbase 250. - In some exemplary embodiments of the invention, components are placed 110 in a mixing well 252 at this stage.
- In other embodiments of the invention, components are placed 110 in mixing well 252 as part of a manufacturing and assembly process. Optionally,
apparatus 200 is supplied assembled as depicted inFIG. 3 . Whenapparatus 200 is supplied assembled with mixture components inside, undesired premature mixing of monomer liquid and polymer powder may be prevented by a variety of methods. Exemplary methods of preventing undesired premature mixing are described below. - Cover 220 includes portions of a drive mechanism. The drive mechanism is optionally a manual mechanism operable by a
handle 210. In the pictured embodiment,cover 220 includes a downward facing protrusion 222 (FIG. 6 ) configured to engage awiping element 260 by means ofengagement arms 262. - In the pictured exemplary embodiment,
engagement arms 262 B function primarily to engageprotrusion 222. - In another exemplary embodiment,
engagement arms 262 A function to engageprotrusion 222 and to engage agroove 264 inbase 250. A relationship betweenengagement arms 262 A andgroove 264 inbase 250 is described below. - A
central mixing element 230 and aplanetary mixing element 240 are visible protruding downwards fromcover 220. Optionally, two or moreplanetary mixing elements 240 are provided. A portion of aplanetary drive gear 270 is also visible in this view. -
Base 250 includes an inner mixing well 252 and a series of inward facing teeth which function as a stationarycircumferential gear 254. Stationarycircumferential gear 254 is a part of the drive mechanism and is configured to engageplanetary drive gear 270 whencover 220 is assembled withbase 250. -
FIG. 3 is a partial cut-away view of assembledapparatus 200 illustrating the drive mechanism in greater detail. Mixingelements optional wiping element 120 has been deployed in the pictured embodiment.Planetary drive gear 270 is positioned above a center axis ofplanetary mixing element 240 and connected thereto so that mixingelement 240 travels and/or rotates together withgear 270.Gear 270 is coupled to cover 220 bydrive shaft 272 seated indrive shaft receptacle 274 ofcover 220. Teeth ofplanetary gear 270 engage complementary teeth of stationarycircumferential gear 254 in mixing well 252 ofbase 250.Planetary mixing element 240 is coupled tocentral mixing element 230 bydrive element 232. Wipingelement 260 concurrently engages an inner surface of mixing well 252 and mixingelements - Operation of the drive mechanism, for example by rotation of
handle 210, causes cover 220 to rotate with respect tobase 250. This causesplanetary drive shaft 272 to advance on a circular path concentric to an inner wall of mixing well 252.Planetary gear 270 engages stationarycircumferential gear 254 so thatplanetary gear 270 rotatesplanetary mixing element 240 asplanetary drive shaft 272 andplanetary mixing element 240 advance along their circular path. In an exemplary embodiment of the invention,drive element 232 is coupled to bothplanetary mixing element 240 andcentral mixing element 230. Optionally,drive element 232 causescentral mixing element 230 to rotate asplanetary mixing element 240 advances. In other embodiments of the invention,central mixing element 230 does not rotate. As mixingelement 240 advances, mixing 140 occurs. -
FIG. 4A is a schematic representation of an exemplary drive mechanism viewed from abovebase 250. The physical relationship betweenplanetary gear 270,planetary drive shaft 272,central mixing element 230, stationarycircumferential gear 254 and drive element 232 (pictured here as a lever) is more clearly visible in this view than in the preceding figure. Engineering considerations of the drive mechanism are discussed below. In an exemplary embodiment of the invention, stationarycircumferential gear 254 has 3 times as many teeth asplanetary drive gear 270. - Mixing
elements well 252 is similarly roughened, serrated or striated to insure formation of a boundary layer in proximity to a surface of the well. - In an exemplary embodiment of the invention, serrations in the form of vertical slits that extend along the full height of mixing
elements 230 and/or 240. Optionally, the longitudinal slits contribute to easy introduction and removal of mixingelements 230 and/or 240 through wiping apertures in wipingelement 260. Optionally, vertical slits are characterized by a depth of 0.1, 0.5 or 1 mm or lesser or greater or intermediate depths. - Exemplary Drive Mechanism Engineering considerations
-
FIG. 4B is an engineering projection showing rotation directions and distances for an exemplary drive mechanism respectively; The view is looking down onbase 250 as forFIG. 4A . - During operation point “A” on an outer surface of
central mixing element 230 will move counterclockwise (arrow) with a radial velocity V (A): -
V(A)=ω1*R1 - where ω1 is a rotational speed of mixing
element 230 in radians/sec and R1 is the radius of mixingelement 230.
During operation point “B” on a surface ofplanetary mixing element 240 will have a radial velocity V(B) comprising the sum of velocity due toplanetary mixing element 240 rotation relative to the axis ofcentral mixing element 230 and velocity due toplanetary mixing element 240 rotation on its own axis: -
V(B)=ω1*R(B)+ω2*R2 -
- where ω2=i*ω1
- where “i” is the ratio between the number of teeth of the stationary
circumferential gear 254 and the number of teeth onplanetary gear 270; - and ω1 is a rotational speed of mixing
element 230; - R(B) is a distance from a center of mixing
element 230 to a closest point (B) on mixingelement 240; and - R2 is the radius of mixing
element 240
During operation point “C” on an opposite surface ofplanetary mixing element 240 will have a radial velocity V(C) comprising the difference between velocity due toplanetary mixing element 240 rotation relative to the axis ofcentral mixing element 230 and velocity due toplanetary mixing element 240 rotation on its own axis:
-
V(C)=ω1*R(C)−i*ω1*R2 -
- where R(C) is a distance from a center of mixing
element 230 to a farthest point (C) on mixingelement 240; and - the remaining terms are as defined above.
Point D on stationarycircumferential gear 254 will have a velocity of zero.
The shear stresses on a mixture flowing between pints A and B, or between points C and D, can be calculated by the subtraction of radial velocities between opposing points (velocity gradients):
The shear stresses between the fixed position and planetary mixing elements correlate to:
- where R(C) is a distance from a center of mixing
-
V(B)−V(A)=ω1*(R(B)−R1+iR2) - The shear stresses between the planetary mixing element and to stationary mixing chamber inner surface correlate to V(C)−V(D)=ω1*(R(C)−iR2).
In an exemplary embodiment of the invention,apparatus 200 is operated manually, so ω1 is set by the operator. Optionally, ω1 can be 10, 15, 22, or 30 RPM or lesser or greater or intermediate values.
In an exemplary embodiment of the invention, R1, R2, R(B), R(C) and i, are selected to meet both geometry considerations and relatively similar velocity gradients that are sufficient to produce adequate shear stresses in consideration of a selected viscosity, such as, for example, 500 Pascal/second. -
FIG. 5 illustrates a theoretic gradient of the shear stress applied to amixture 500 flowing between a two elements (e.g.planetary mixing element 240 andcentral mixing element 230 orplanetary mixing element 240 and an inner wall of mixing well 254). As the viscosity ofmixture 500 increases, the shear stress necessary for mixing also increases. - In an exemplary embodiment of the invention, sufficient shear force to mix a
mixture 500 characterized by a viscosity of 500 Pascal/second is provided by adjusting distance between the two mixing elements (A to B inFIG. 4B ) or betweenplanetary mixing element 240 and an inner wall of mixing well 254 (C to D inFIG. 4B ) to 1 to 5 mm, optionally about 2 mm. Alternatively or additionally, shear force may be adjusted by varying the surface area of mixingelements 230 and/or 240 and/or an inner surface of well 252 which contacts the mixture. -
FIGS. 6 , 7 and 8 illustrate placement and function ofoptional wiping element 260 according to an exemplary embodiment of the invention. -
FIG. 6 illustrates wipingelement 260 engaging downward facingprotrusion 222 by means ofengagement arms B. Circumferential groove 264 of mixing well 252 is empty at this stage. Mixingelements element 260. -
FIG. 7 illustratescover 220 assembled onbase 250 so that wipingelements floor 258 of mixing well 252.Engagement arms 262 of wipingelement 260 are seated ingroove 264 of mixing well 252 (magnified in inset for clarity). Each ofengagement arms 262 slides circumferentially around mixing well 252 ingroove 264 asplanetary mixing element 240 travels around mixing well 252. -
FIG. 8 illustratesremoval 150 of mixingelements Engagement arms 262 are retained bygroove 264 so that wiping element is locked into position. Removal ofelements automatic wiping 152 by the edges of the wiping apertures. -
FIGS. 9 and 10 illustrate a transfer mechanism according to exemplary embodiments of the invention as previously disclosed in co-pending U.S. application Ser. No. 11/360,251, the disclosure of which is fully incorporated herein by reference.FIG. 9 is a cross-sectional view andFIG. 10 is a partial cut-away view in perspective. -
FIGS. 9 and 10 illustrate anexemplary transfer element 900 including atransfer piston cup 950 inserted in mixing well 254. In the pictured embodiment,threads 956 ofpiston cup 950 engagethreads 256 ofbase 250. Astransfer piston cup 950 is screwed ontobase 250,floor 958 oftransfer piston cup 950 is forced downwards and towardsfloor 258 of mixing well 252. This action applies downward pressure on wipingelement 260. The downward pressure causesengagement arms 262 to be released fromgroove 264. Onceengagement arms 262 are released, wipingelement 260 is free to travel downwards towardsfloor 258 of mixing well 252. Optionally, wipingelement 260 also serves also as a piston which pushes the mixture intoinjection reservoir 910. - In the pictured embodiment
transfer piston cup 950 is fitted with a second set ofthreads 952 which engage matchingthreads 930 oninjection reservoir 910. Inoperation injection reservoir 910 is attached to transferpiston cup 950 bythreads transfer piston cup 950 is inserted into mixing well 252. Astransfer piston cup 950 descends into mixing well 252, contents of mixing well 252 (e.g. high viscosity bone cement) are forced upwards intoinjection reservoir 910.Injection nozzle 920 serves to release air frominjection reservoir 910 so that no resistive pressure accumulates. The mixed material has been transferred 160 to the injector at this stage. Optionally, an operator of the apparatus knows thatreservoir 910 is full when bone cement exitsinjection nozzle 920. - According to various exemplary embodiments of the invention, an inner volume of the mixing well 252 is 5, optionally 10, optionally 20, optionally 40, optionally 60, optionally 80, optionally 100 ml or lesser or greater or intermediate volumes. In an exemplary embodiment of the invention, the mixing well volume is 50 to 60 ml, optionally about 66 ml, and 10 to 20 ml of mixture, optionally about 15 ml of mixture is placed in the chamber for mixing. In an exemplary embodiment of the invention, a portion of the inner volume of
well 252 is occupied by mixingelements - Optionally, an inner diameter of the mixing well is 20, optionally 40, optionally 60, optionally 80, optionally 100 mm or lesser or greater or intermediate sizes. In an exemplary embodiment of the invention, the inner diameter of the mixing well is 40 to 50 mm, optionally about 46 mm.
- Optionally, a height of the mixing well is 20, although it can be 40, 60, 80, or 100 mm or lesser or greater or intermediate sizes. In an exemplary embodiment of the invention, the height of the mixing well is 35 to 45 mm, optionally about 40 mm.
- Optionally, an aspect ratio (diameter/height) of the mixing well is 0.7, 0.9, 1.1, or 1.3, or lesser or greater or intermediate values. In an exemplary embodiment of the invention, aspect ratio (diameter/height) of the mixing well is 1.1 to 1.2, optionally about 1.15.
- In an exemplary embodiment of the invention, a distance (d1) between the central mixing element and the planetary mixing element (indicated by A to B in
FIG. 4A ) and/or a distance (d2) between the planetary mixing element and an inner wall of the mixing well (indicated by C to D inFIG. 4A ) is 1, 2, 3, 4, or 5 mm or lesser or greater or intermediate distances. In an exemplary embodiment of the invention, d1 is substantially equivalent to d2. - In typical vertebrae treatment procedures, a volume of approximately 5 ml is injected in a single vertebra. It is common to prepare a batch of approximately 8 ml of cement if a single vertebra is to be injected, approximately 15 ml of cement if two vertebrae are to be injected and progressively larger volumes if three or more vertebrae are to be injected. Combination of powdered polymer component and liquid monomer component leads to a reduction in total mixture volume as the polymer is wetted by the monomer. For example, 40 to 50 ml of polymer powder may be mixed 112 with 7 to 9 ml of monomer liquid to produce 18 ml of polymerized cement. In an exemplary embodiment of the invention, a volume of
well 252 is selected to accommodate the large initial column of monomer powder, even when a significantly smaller batch of cement is being prepared. - In an exemplary embodiment of the invention, a dead volume of cement remaining in well 242 after transfer to
injection reservoir 910 bytransfer element 900 is less than 2, 1, or 0.5 ml or lesser or intermediate values. - In an exemplary embodiment of the invention, a diameter of
central mixing element 230 and a diameter ofinjection reservoir 910 are both equivalent to a diameter of an aperture in wipingelement 260. Optionally, this conformity of diameters reduces a dead volume of cement left in well 252 after operation oftransfer apparatus 900. Optionally the diameters are all approximately 18 mm. - In other embodiments of the invention (not shown), mixing well 252 of
base 250 is transferred to an injection apparatus and cement is injected into a subject directly from well 252. Optionally, this occurs after removal of mixingelements - In an exemplary embodiment of the invention, component parts of the mixing apparatus are constructed of Polyamides (e.g., Nylon) and/or Polypropylene.
- Optionally, some portions of the apparatus are constructed of a metal, for example stainless steel. In an exemplary embodiment of the invention, metal is employed to construct parts which are subject to large forces, such as friction or torque. Optionally, one or more of
handle 210, gears (e.g. 270), teeth (e.g. 254), drive arms (e.g. 232) and mixing elements (e.g. 230 and/or 240) are constructed of metal. - In an exemplary embodiment of the invention,
apparatus 200 is provided with instructions for use. In an exemplary embodiment of the invention, the instructions indicate a procedure for achieving complete mixing of a mixture placed inwell 252. - Optionally, these instructions indicate an amount of time recommended to insure complete mixing. In an exemplary embodiment of the invention, the time is 30 to 90 seconds, optionally 30 to 60 seconds, optionally about 45 seconds or lesser or greater or intermediate amounts of time.
- Optionally, these instructions indicate a number of turns recommended to insure complete mixing. In an exemplary embodiment of the invention, the number of turns is 20 to 100, optionally 40 to 60, optionally about 50 or a lesser or greater or intermediate number.
- Optionally, these instructions indicate a signal which will be presented to the user when mixing is complete. The signal may be a visual signal (e.g. indicator light) or an audible signal (e.g. buzzer or bell) or a tactile signal (
e.g. gear 270 slips onteeth 254 when a desired viscosity is reached). In an exemplary embodiment of the invention, the signal is triggered by a closed feedback loop. The loop may rely upon, for example, an indirect measure of viscosity (e.g. torque), centripetal force, time, number of revolutions of a portion of apparatus 200 (e.g. handle 210,gear 270 or mixingelement 230 and/or 240) or mixture volume. - Optionally, the apparatus combines a mechanism that allow turning of handle only during a preset window of time and/or number of rotations.
- Shear force on a mixture within well 252 is affected primarily by surface properties, distance between surfaces, and differences in velocities between surfaces.
- Surface properties of mixing
elements FIG. 5 ). Increasing roughness (e.g. by serration or striation) preventsmixture 500 from slipping against these surfaces by increasing the force of friction. When the surfaces are sufficiently roughened, a boundary layer will have a relative velocity of zero with respect to the surface. Optionally, this zero relative velocity contributes to increased shear force. - Distances between surfaces are inversely related to shear forces acting on a
mixture 500 moving between the surfaces. In an exemplary embodiment of the invention, as distances defined by lines A-B and/or C-D (FIG. 4B ) increase, an applied shear force to a portion ofmixture 500 crossing those lines decreases. - Differences in relative velocities between portions of
mixer 200 also affect shear forces onmixture 200. As the difference in relative velocities increases, the applied shear force to a portion ofmixture 500 flowing between the elements increases. The relative velocities are optionally influenced by angular velocities and/or radial velocities and/or radius of the elements involved as discussed in more detail above. In an exemplary embodiment of the invention, differences in relative velocity are amplified by imparting angular velocities with different directions to mixingelements - Because some components of a bone cement mixture may have an unpleasant odor and/or be toxic if inhaled, some exemplary embodiments of the invention include safety features to reduce exposure to undesired vapors.
- In an exemplary embodiment of the invention, locking
ring 224 is equipped with an air-tight seal (e.g. rubber or silicon) which prevents vapors from escaping from well 252. - Alternatively or additionally,
apparatus 200 may be provided with an evacuation port (not shown) connectable to a vacuum source. In an exemplary embodiment of the invention, the vacuum source is a standard “wall suction” unit in a hospital operating room and the undesired vapors are from an MMA component of a bone cement mixture. - In cases where
apparatus 200 is supplied with components to be mixed inside well 252, a method for preventing undesired premature mixing may be implemented. - One exemplary method of preventing undesired premature mixing of monomer liquid and polymer powder is to provide the monomer liquid in a sealed bag or capsule which is burst when
apparatus 200 is operated. The capsule may be burst when it is drawn across line A-B or C-D by the flow ofmixture 500. In an exemplary embodiment of the invention, the capsule is designed so that it is characterized by a smallest dimension which exceeds the length of A-B and/or C-D. In an exemplary embodiment of the invention, the bag or capsule is constructed of a biocompatible material which may be injected together with the bone cement. - Another exemplary method of preventing undesired premature mixing of monomer liquid and polymer powder is to provide the monomer liquid inside
central mixing element 230. Optionally, partial removal ofcover 220 frombase 250 permits the monomer liquid to exit mixingelement 230 intowell 252. Optionally, tightening of lockingring 224 breaks a seal in mixingelement 230. Breaking the seal releases the liquid monomer onto the powder component. - Another exemplary method of preventing undesired premature mixing of monomer liquid and polymer powder is to provide the monomer liquid in a cavity inside a wall of mixing well 252. Optionally, contents of the cavity are dumped into well 252 manually or automatically when mixing commences.
- The present invention has been described using detailed descriptions of embodiments thereof that are provided by way of example and are not intended to necessarily limit the scope of the invention. In particular, numerical values may be higher or lower than ranges of numbers set forth above and still be within the scope of the invention. The described embodiments comprise different features, not all of which are required in all embodiments of the invention. Some embodiments of the invention utilize only some of the features or possible combinations of the features. Alternatively or additionally, portions of the invention described/depicted as a single unit may reside in two or more separate physical entities which act in concert to perform the described/depicted function. Alternatively or additionally, portions of the invention described/depicted as two or more separate physical entities may be integrated into a single physical entity to perform the described/depicted function. Variations of embodiments of the present invention that are described and embodiments of the present invention comprising different combinations of features noted in the described embodiments can be combined in all possible combinations including, but not limited to use of features described in the context of one embodiment in the context of any other embodiment. The scope of the invention is limited only by the following claims.
- In the description and claims of the present application, each of the verbs “comprise”, “include” and “have” as well as any conjugates thereof, are used to indicate that the object or objects of the verb are not necessarily a complete listing of members, components, elements or parts of the subject or subjects of the verb.
- All publications and/or patents and/or product descriptions cited in this document are fully incorporated herein by reference to the same extent as if each had been individually incorporated herein by reference.
Claims (41)
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US15/041,572 US10631906B2 (en) | 2005-11-22 | 2016-02-11 | Apparatus for transferring a viscous material |
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Cited By (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007015202A2 (en) | 2005-07-31 | 2007-02-08 | Depuy Spine, Inc., A Johnson & Johnson Company | Bone cement and methods of use thereof |
US20090114616A1 (en) * | 2005-09-05 | 2009-05-07 | Gerard Andrew White | Blender with Co-Operating Jug and Blades |
US20100114174A1 (en) * | 2008-10-30 | 2010-05-06 | Bryan Jones | Systems and Methods for Delivering Bone Cement to a Bone Anchor |
FR2954181A1 (en) * | 2009-12-22 | 2011-06-24 | Michel Marcel Andre Loiselet | CULINARY PREPARATION APPARATUS, IN PARTICULAR FOR THE PREPARATION OF FLOUR-BASED PASTA |
WO2011082015A3 (en) * | 2009-12-31 | 2011-08-25 | Cook Incorporated | Vertebroplasty cement mixer injector device |
US8066713B2 (en) | 2003-03-31 | 2011-11-29 | Depuy Spine, Inc. | Remotely-activated vertebroplasty injection device |
US8287538B2 (en) | 2008-01-14 | 2012-10-16 | Conventus Orthopaedics, Inc. | Apparatus and methods for fracture repair |
US20120307586A1 (en) * | 2005-11-22 | 2012-12-06 | Depuy Spine, Inc. | Mixing apparatus |
US8361078B2 (en) | 2003-06-17 | 2013-01-29 | Depuy Spine, Inc. | Methods, materials and apparatus for treating bone and other tissue |
US8415407B2 (en) | 2004-03-21 | 2013-04-09 | Depuy Spine, Inc. | Methods, materials, and apparatus for treating bone and other tissue |
US8579908B2 (en) | 2003-09-26 | 2013-11-12 | DePuy Synthes Products, LLC. | Device for delivering viscous material |
US8906022B2 (en) | 2010-03-08 | 2014-12-09 | Conventus Orthopaedics, Inc. | Apparatus and methods for securing a bone implant |
US8950929B2 (en) | 2006-10-19 | 2015-02-10 | DePuy Synthes Products, LLC | Fluid delivery system |
US8961518B2 (en) | 2010-01-20 | 2015-02-24 | Conventus Orthopaedics, Inc. | Apparatus and methods for bone access and cavity preparation |
US8992541B2 (en) | 2003-03-14 | 2015-03-31 | DePuy Synthes Products, LLC | Hydraulic device for the injection of bone cement in percutaneous vertebroplasty |
US9155580B2 (en) | 2011-08-25 | 2015-10-13 | Medos International Sarl | Multi-threaded cannulated bone anchors |
US9381024B2 (en) | 2005-07-31 | 2016-07-05 | DePuy Synthes Products, Inc. | Marked tools |
US20160278935A1 (en) * | 2013-11-11 | 2016-09-29 | 41Medical Ag | Expandable spinal implant |
WO2017048980A1 (en) * | 2015-09-15 | 2017-03-23 | Entrochem, Inc. | Kits and related methods for efficient use of multi-component resin systems |
US9642932B2 (en) | 2006-09-14 | 2017-05-09 | DePuy Synthes Products, Inc. | Bone cement and methods of use thereof |
US9730739B2 (en) | 2010-01-15 | 2017-08-15 | Conventus Orthopaedics, Inc. | Rotary-rigid orthopaedic rod |
US9918767B2 (en) | 2005-08-01 | 2018-03-20 | DePuy Synthes Products, Inc. | Temperature control system |
US10022132B2 (en) | 2013-12-12 | 2018-07-17 | Conventus Orthopaedics, Inc. | Tissue displacement tools and methods |
USRE47427E1 (en) | 1999-01-27 | 2019-06-11 | Medtronic Holding Company Sárl | Expandable intervertebral spacer |
US10918426B2 (en) | 2017-07-04 | 2021-02-16 | Conventus Orthopaedics, Inc. | Apparatus and methods for treatment of a bone |
US11096864B2 (en) * | 2016-11-10 | 2021-08-24 | Medisca Pharmaceutique Inc. | Adapter for a dispensing container in a planetary mixer |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8783001B2 (en) * | 2010-12-10 | 2014-07-22 | Tie Not Incorporated | Balloon filling device |
GB2519805B (en) * | 2013-10-31 | 2018-08-01 | Kenwood Ltd | Food-processing tools and food-processing appliances incorporating same |
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US11660134B2 (en) | 2019-06-13 | 2023-05-30 | Medos International Sarl | Instruments and methods for delivering bone cement to a bone screw |
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Citations (100)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US843587A (en) * | 1906-01-29 | 1907-02-12 | Henry Hannon De Pew | Surgical instrument. |
US1612996A (en) * | 1926-02-23 | 1927-01-04 | Waagbo Herman | Cream-testing device |
US1894274A (en) * | 1930-08-22 | 1933-01-17 | Raynaldo P Jacques | Lubricating apparatus |
US2067458A (en) * | 1934-07-13 | 1937-01-12 | Nat Rubber Machinery Co | Rubber mixing mill |
US2394488A (en) * | 1943-05-07 | 1946-02-05 | Lincoln Eng Co | Lubricating apparatus |
US2435647A (en) * | 1945-02-21 | 1948-02-10 | Martin O Engseth | Grease gun |
US2497762A (en) * | 1945-10-04 | 1950-02-14 | Ernest W Davis | Lubrication gun |
US2874877A (en) * | 1956-09-11 | 1959-02-24 | Alvin C Spencer | Dispensing device and container therefor |
US2970773A (en) * | 1959-10-19 | 1961-02-07 | Minnesota Mining & Mfg | Fluid mixing and applying apparatus and method |
US3075746A (en) * | 1958-07-10 | 1963-01-29 | Baker Perkins Inc | Mixer for explosive materials |
US3426364A (en) * | 1966-08-25 | 1969-02-11 | Colorado State Univ Research F | Prosthetic appliance for replacing one or more natural vertebrae |
US3789727A (en) * | 1972-06-05 | 1974-02-05 | Eaton Corp | Fastener |
US3867728A (en) * | 1971-12-30 | 1975-02-25 | Cutter Lab | Prosthesis for spinal repair |
US3931914A (en) * | 1973-07-10 | 1976-01-13 | Max Kabushiki Kaisha | Powder ejector |
US4185072A (en) * | 1977-02-17 | 1980-01-22 | Diemolding Corporation | Orthopedic cement mixer |
US4189065A (en) * | 1976-02-04 | 1980-02-19 | Espe Fabrik Pharmazeutischer Praeparate Gmbh | Metering dispenser for high-viscosity compositions |
US4250887A (en) * | 1979-04-18 | 1981-02-17 | Dardik Surgical Associates, P.A. | Remote manual injecting apparatus |
US4309777A (en) * | 1980-11-13 | 1982-01-12 | Patil Arun A | Artificial intervertebral disc |
US4312343A (en) * | 1979-07-30 | 1982-01-26 | Leveen Harry H | Syringe |
US4313434A (en) * | 1980-10-17 | 1982-02-02 | David Segal | Fracture fixation |
US4373217A (en) * | 1979-02-16 | 1983-02-15 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Implantation materials and a process for the production thereof |
US4494535A (en) * | 1981-06-24 | 1985-01-22 | Haig Armen C | Hip nail |
US4500658A (en) * | 1983-06-06 | 1985-02-19 | Austenal International, Inc. | Radiopaque acrylic resin |
US4562598A (en) * | 1981-04-01 | 1986-01-07 | Mecron Medizinische Produkte Gmbh | Joint prosthesis |
US4636217A (en) * | 1985-04-23 | 1987-01-13 | Regents Of The University Of Minnesota | Anterior spinal implant |
US4642099A (en) * | 1984-07-31 | 1987-02-10 | N.J. Phillips Pty. Limited | Injector |
US4717383A (en) * | 1984-07-31 | 1988-01-05 | N.J. Phillips Pty. Limited | Injector |
US4718910A (en) * | 1985-07-16 | 1988-01-12 | Klaus Draenert | Bone cement and process for preparing the same |
US4722948A (en) * | 1984-03-16 | 1988-02-02 | Dynatech Corporation | Bone replacement and repair putty material from unsaturated polyester resin and vinyl pyrrolidone |
US4804023A (en) * | 1986-05-23 | 1989-02-14 | Avdel Limited, British Company | Hydraulic fluid replenishment device |
US4892550A (en) * | 1985-12-30 | 1990-01-09 | Huebsch Donald L | Endoprosthesis device and method |
US4892231A (en) * | 1986-07-16 | 1990-01-09 | Metal Box P.L.C. | Pump chamber dispenser |
US4902649A (en) * | 1986-09-10 | 1990-02-20 | Showa Denko Kabushiki Kaisha | Hard tissue substitute composition |
US4904260A (en) * | 1987-08-20 | 1990-02-27 | Cedar Surgical, Inc. | Prosthetic disc containing therapeutic material |
US4983164A (en) * | 1987-04-14 | 1991-01-08 | Astra Meditec Ab | Automatic two-chamber injector |
US4994065A (en) * | 1990-05-18 | 1991-02-19 | Zimmer, Inc. | Apparatus for dispensing low viscosity semi-fluid material under pressure |
US4995868A (en) * | 1988-10-12 | 1991-02-26 | Bard Limited | Catheter |
US5078919A (en) * | 1990-03-20 | 1992-01-07 | The United States Of America As Represented By The United States Department Of Energy | Composition containing aerogel substrate loaded with tritium |
US5181918A (en) * | 1990-08-10 | 1993-01-26 | Thera Patent Gmbh & Co. Kg Gesellschaft Fuer Industrielle Schutzrechte | Granules syringe |
US5188259A (en) * | 1991-02-01 | 1993-02-23 | Petit Jeffrey D | Caulking gun with belt worn cartridge |
US5275214A (en) * | 1992-10-28 | 1994-01-04 | Rehberger Kevin M | Apparatus for unloading pressurized fluid |
US5276070A (en) * | 1990-01-25 | 1994-01-04 | Pfizer Hospital Products Group, Inc. | Bone cement |
US5277339A (en) * | 1992-03-26 | 1994-01-11 | Alemite Corporation | Dual mode pistol-grip grease gun |
US5279555A (en) * | 1992-08-24 | 1994-01-18 | Merck & Co., Inc. | Device for injecting implants |
US5380772A (en) * | 1989-12-11 | 1995-01-10 | G-C Toshi Kogyo Corporation | Modelling liquid for dental porcelain |
US5385081A (en) * | 1993-09-09 | 1995-01-31 | Arde Incorporated | Fluid storage tank employing a shear seal |
US5385566A (en) * | 1992-02-20 | 1995-01-31 | Ullmark; Goesta | Device and a method for use in transplantation of bone tissue material |
US5387191A (en) * | 1989-02-06 | 1995-02-07 | Board Of Regents Of The Univ. Of Okla. | Flushing needle |
US5390683A (en) * | 1991-02-22 | 1995-02-21 | Pisharodi; Madhavan | Spinal implantation methods utilizing a middle expandable implant |
US5480400A (en) * | 1993-10-01 | 1996-01-02 | Berger; J. Lee | Method and device for internal fixation of bone fractures |
US5480403A (en) * | 1991-03-22 | 1996-01-02 | United States Surgical Corporation | Suture anchoring device and method |
US5482187A (en) * | 1993-09-13 | 1996-01-09 | Hygienix, Inc. | Dispenser for viscous substances |
US5492247A (en) * | 1994-06-02 | 1996-02-20 | Shu; Aling | Automatic soap dispenser |
US5494349A (en) * | 1991-12-06 | 1996-02-27 | Summit Medical Ltd. | Bone cement mixing device |
US5591197A (en) * | 1995-03-14 | 1997-01-07 | Advanced Cardiovascular Systems, Inc. | Expandable stent forming projecting barbs and method for deploying |
US5601557A (en) * | 1982-05-20 | 1997-02-11 | Hayhurst; John O. | Anchoring and manipulating tissue |
US5603701A (en) * | 1995-03-27 | 1997-02-18 | Ultradent Products, Inc. | Syringe apparatus with threaded plunger for delivering tooth composites and other solid yet pliable materials |
US5704895A (en) * | 1979-12-28 | 1998-01-06 | American Medical Systems, Inc. | Implantable penile prosthetic cylinder with inclusive fluid reservoir |
US5707390A (en) * | 1990-03-02 | 1998-01-13 | General Surgical Innovations, Inc. | Arthroscopic retractors |
US5718707A (en) * | 1997-01-22 | 1998-02-17 | Mikhail; W. E. Michael | Method and apparatus for positioning and compacting bone graft |
US5720753A (en) * | 1991-03-22 | 1998-02-24 | United States Surgical Corporation | Orthopedic fastener |
US5865802A (en) * | 1988-07-22 | 1999-02-02 | Yoon; Inbae | Expandable multifunctional instruments for creating spaces at obstructed sites endoscopically |
US6017349A (en) * | 1997-06-05 | 2000-01-25 | Sulzer Orthopaedie, Ag | Transport and processing apparatus for a two-component material |
US6019789A (en) * | 1998-04-01 | 2000-02-01 | Quanam Medical Corporation | Expandable unit cell and intraluminal stent |
US6019765A (en) * | 1998-05-06 | 2000-02-01 | Johnson & Johnson Professional, Inc. | Morsellized bone allograft applicator device |
US6019776A (en) * | 1997-10-14 | 2000-02-01 | Parallax Medical, Inc. | Precision depth guided instruments for use in vertebroplasty |
US6020396A (en) * | 1998-03-13 | 2000-02-01 | The Penn State Research Foundation | Bone cement compositions |
US6168597B1 (en) * | 1996-02-28 | 2001-01-02 | Lutz Biedermann | Bone screw |
US6174935B1 (en) * | 1997-12-24 | 2001-01-16 | Gc Corporation | Dental adhesive kit |
US6176607B1 (en) * | 1997-07-29 | 2001-01-23 | Stryker Technologies Corporation | Apparatus for dispensing a liquid component of a two-component bone cement and for storing, mixing, and dispensing the cement |
US6183441B1 (en) * | 1996-12-18 | 2001-02-06 | Science Incorporated | Variable rate infusion apparatus with indicator and adjustable rate control |
US6183516B1 (en) * | 1998-10-08 | 2001-02-06 | Sulzer Orthopedics Inc. | Method for improved bonding of prosthetic devices to bone |
US6187015B1 (en) * | 1997-05-02 | 2001-02-13 | Micro Therapeutics, Inc. | Expandable stent apparatus and method |
US6190381B1 (en) * | 1995-06-07 | 2001-02-20 | Arthrocare Corporation | Methods for tissue resection, ablation and aspiration |
US20020008122A1 (en) * | 2000-07-06 | 2002-01-24 | Stefan Ritsche | Discharge apparatus for media |
US20020010472A1 (en) * | 2000-06-30 | 2002-01-24 | Kuslich Stephen D. | Tool to direct bone replacement material |
US20020010471A1 (en) * | 2000-02-04 | 2002-01-24 | Wironen John F. | Methods for injecting materials into bone |
US20020013553A1 (en) * | 2000-05-25 | 2002-01-31 | Pajunk Gmbh | Apparatus for the application of bone cement and a cannula for such an apparatus |
US6348055B1 (en) * | 1999-03-24 | 2002-02-19 | Parallax Medical, Inc. | Non-compliant system for delivery of implant material |
US6348518B1 (en) * | 1997-12-10 | 2002-02-19 | R. Eric Montgomery | Compositions for making an artificial prosthesis |
US6350271B1 (en) * | 1999-05-17 | 2002-02-26 | Micrus Corporation | Clot retrieval device |
US6502608B1 (en) * | 2000-02-14 | 2003-01-07 | Telios Orthopedic Systems, Inc. | Delivery apparatus, nozzle, and removable tip assembly |
US20030018339A1 (en) * | 2001-07-19 | 2003-01-23 | Higueras Antonio Perez | Applicator device for controllably injecting a surgical cement into bones |
US20030031698A1 (en) * | 2000-01-31 | 2003-02-13 | Roeder Ryan K. | Composite biomaterial including anisometric calcium phosphate reinforcement particles and related methods |
US20030032929A1 (en) * | 1998-12-09 | 2003-02-13 | Mcguckin James F. | Hollow curved superelastic medical needle and method |
US20030036763A1 (en) * | 1999-03-16 | 2003-02-20 | Mohit Bhatnagar | Apparatus and method for fixation of osteoporotic bone |
US20030040718A1 (en) * | 2001-08-21 | 2003-02-27 | Richard Kust | Apparatus for delivering a viscous liquid to a surgical site |
US6676664B1 (en) * | 1999-08-05 | 2004-01-13 | Grupo Grifols, S.A. | Device for metering hardenable mass for vertebroplastia and other similar bone treatments |
US20040010263A1 (en) * | 1998-06-01 | 2004-01-15 | Kyphon Inc. | Expandable preformed structures for deployment in interior body regions |
US6689823B1 (en) * | 1999-03-31 | 2004-02-10 | The Brigham And Women's Hospital, Inc. | Nanocomposite surgical materials and method of producing them |
US20040029996A1 (en) * | 2002-05-29 | 2004-02-12 | Heraeus Kulzer Gmbh & Co. Kg | Bone cement mixture and x-ray contrast medium as well as method for their preparation |
US20050014273A1 (en) * | 2001-08-29 | 2005-01-20 | Dahm Michael Werner | Method and device for preparing a sample of biological origin in order to determine at least one constituent contained therein |
US20050015148A1 (en) * | 2003-07-18 | 2005-01-20 | Jansen Lex P. | Biocompatible wires and methods of using same to fill bone void |
US20050025622A1 (en) * | 2003-07-28 | 2005-02-03 | Pratt & Whitney Canada Corp. | Blade inlet cooling flow deflector apparatus and method |
US6852439B2 (en) * | 2001-05-15 | 2005-02-08 | Hydrogenics Corporation | Apparatus for and method of forming seals in fuel cells and fuel cell stacks |
US6994465B2 (en) * | 2002-03-14 | 2006-02-07 | Stryker Instruments | Mixing assembly for mixing bone cement |
US20060035997A1 (en) * | 2004-08-10 | 2006-02-16 | Orlowski Jan A | Curable acrylate polymer compositions featuring improved flexural characteristics |
US20060041033A1 (en) * | 2003-02-13 | 2006-02-23 | Adrian Bisig | Injectable bone-replacement mixture |
US20070019802A1 (en) * | 2005-06-30 | 2007-01-25 | Symbol Technologies, Inc. | Audio data stream synchronization |
US20120307586A1 (en) * | 2005-11-22 | 2012-12-06 | Depuy Spine, Inc. | Mixing apparatus |
Family Cites Families (716)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE226956C (en) | ||||
DE136018C (en) | ||||
GB179502045A (en) | Bramah Joseph | Obtaining and Applying Motive Power. | ||
US229932A (en) * | 1880-07-13 | witsil | ||
US370335A (en) * | 1887-09-20 | Mixing-machine | ||
DE293485C (en) | 1900-01-01 | |||
US817973A (en) | 1904-06-06 | 1906-04-17 | Caspar Friedrich Hausmann | Uterine dilator. |
US833044A (en) | 1906-03-13 | 1906-10-09 | Claudius Ash Sons & Company 1905 Ltd | Dental instrument. |
GB190720207A (en) | 1907-09-10 | 1908-06-25 | Karl Krautschneider | Medical Apparatus for Injecting Purposes. |
US1175530A (en) | 1913-04-28 | 1916-03-14 | American Bakers Machinery Company | Cake-mixer. |
GB191408331A (en) | 1913-05-30 | 1914-05-28 | George Arthur Pullen | An Improved Snap for Pneumatic Hammers. |
US1612281A (en) * | 1922-11-14 | 1926-12-28 | Columbia Metal Products Compan | Mixing apparatus |
US1733516A (en) * | 1928-12-03 | 1929-10-29 | Charles F Rodin | Agitator |
US1929247A (en) | 1931-01-20 | 1933-10-03 | George N Hein | Syringe equipment and apparatus |
GB408668A (en) | 1932-10-12 | 1934-04-12 | Cecil Roberts Norman | Improvements in and relating to wall plugs and similar fastening devices |
US2123712A (en) | 1935-04-29 | 1938-07-12 | Lubrication Corp | Lubricating device |
US2234558A (en) | 1936-11-13 | 1941-03-11 | Huston Tom | Combined dispensing and applying device |
GB486638A (en) | 1937-09-07 | 1938-06-08 | Heinrich Hagemeier | Improvements in dental syringes |
US2193517A (en) | 1938-02-10 | 1940-03-12 | Lindstrom Bengt | Closing means for tubes, bottles, or other containers |
US2283915A (en) | 1938-12-01 | 1942-05-26 | Samuel F Cole | Syringe |
US2362523A (en) | 1942-10-02 | 1944-11-14 | Cutter Lab | Suspension member |
US2521569A (en) | 1945-07-27 | 1950-09-05 | Ernest W Davis | Lubricant compressor |
US2425867A (en) | 1945-09-20 | 1947-08-19 | Ernest W Davis | Lubricating apparatus |
US2577780A (en) | 1950-05-09 | 1951-12-11 | Compule Corp | Crowned cupped resilient plug for cylindrical passages |
US2567960A (en) | 1949-10-03 | 1951-09-18 | William R Myers | Plastic extrusion gun |
US2745575A (en) | 1951-10-15 | 1956-05-15 | Alvin C Spencer | Printing ink holder and dispenser, including a cylindrical container and piston |
DE868497C (en) | 1951-11-18 | 1953-02-26 | Robert Schoettle K G | Motor-driven small kitchen machine |
DE1075561B (en) * | 1953-09-15 | 1960-02-18 | zugl | Mixing and kneading machine |
US2773500A (en) | 1955-01-26 | 1956-12-11 | Harold S Young | Intraosseous fluid injection instrument |
US2918841A (en) | 1956-11-01 | 1959-12-29 | Illinois Tool Works | Blind fastener formed of plastic and containing longitudinal slots which permit rosette type of distortion of shank |
AT202407B (en) | 1957-08-02 | 1959-03-10 | Vertriebs Ges Ing Wagner | High pressure gun for grease and oil |
DE1810799U (en) | 1958-02-14 | 1960-05-05 | Metallwerk Salmen K G | FLUTE HOOD LOCK FOR WATER BOILER, WITH MOUNTED ELECTRIC IMMERSION BOATER. |
US3058413A (en) | 1959-09-26 | 1962-10-16 | Carle & Montanari Spa | Roller or trough machine for the final working up of chocolate |
US3108593A (en) | 1961-03-13 | 1963-10-29 | Jacob A Glassman | Surgical extractor |
US3063449A (en) | 1961-05-23 | 1962-11-13 | Arthur R P Schultz | Syringe holder |
US3151847A (en) * | 1962-03-19 | 1964-10-06 | Day J H Co | Vertical mixer construction |
US3224744A (en) * | 1962-03-19 | 1965-12-21 | Day J H Co | Vertical mixer construction |
US3225760A (en) | 1962-11-14 | 1965-12-28 | Orthopaedic Specialties Corp | Apparatus for treatment of bone fracture |
US3198194A (en) | 1963-05-13 | 1965-08-03 | Upjohn Co | Admixing storage container with means preventing inadvertent removal of closure means |
US3216616A (en) | 1964-03-02 | 1965-11-09 | Jr Homer Blankenship | Syringe with upper and lower bores |
US3362793A (en) * | 1964-06-17 | 1968-01-09 | Michelin & Cie | Back flow-preventing reactor for continuous polymerization |
US3254494A (en) | 1964-11-10 | 1966-06-07 | E H Sargent & Co | Temperature control apparatus |
US3381566A (en) | 1966-05-06 | 1968-05-07 | La Roy B. Passer | Hollow wall anchor bolt |
DE1283448B (en) | 1967-03-06 | 1968-11-21 | Bauknecht Gmbh G | Power-driven turntable for kitchen machines |
FR1528920A (en) | 1967-05-05 | 1968-06-14 | Multi-capacity cartridge for conditioning pre-dosed substances | |
FR1548575A (en) | 1967-10-25 | 1968-12-06 | ||
US3515873A (en) | 1968-01-11 | 1970-06-02 | Univ Of Kentucky Research Foun | Method and apparatus for analyzing and calibrating radiation beams of x-ray generators |
DE1992767U (en) | 1968-03-27 | 1968-08-29 | Peter Dr Pogacar | DEVICE FOR FINE DOSING AND INTRODUCTION OF LIQUIDS FOR ANALYTICAL OR TREATMENT PURPOSES INTO ANOTHER MEDIUM. |
US3559956A (en) * | 1968-05-27 | 1971-02-02 | Du Pont | Planetary gear mixer |
DE1810799A1 (en) | 1968-11-25 | 1970-06-04 | Dr Med Gerhard Metz | Compression medullary nail for pressure osteosynthesis |
CH508202A (en) | 1969-02-26 | 1971-05-31 | Micromedic Systems Inc | Ratchet mechanism for driving a rotating member and use of this mechanism |
DK125488B (en) | 1969-05-30 | 1973-02-26 | L Mortensen | Tubular expansion dowel body or similar fastener and method of making the same. |
US3568885A (en) | 1969-07-30 | 1971-03-09 | Nasa | Thickness measuring and injection device |
US3605745A (en) | 1969-12-15 | 1971-09-20 | Milton Hodosh | Dental injection apparatus |
US3701350A (en) | 1970-07-28 | 1972-10-31 | Harvey C Guenther | Blood exchanging apparatus and process |
US3659602A (en) | 1970-12-30 | 1972-05-02 | Nosco Plastics | Two component syringe |
US3674011A (en) | 1971-01-12 | 1972-07-04 | United Medical Lab Inc | Means for and method of transfering blood from a patient to multiple test tubes within a vacuum |
US3750667A (en) | 1972-01-31 | 1973-08-07 | N Pshenichny | Device for intraosseous injection of liquid substances |
US3901408A (en) | 1972-06-07 | 1975-08-26 | Bayer Ag | Machine including means for independently adjusting the dose of two reactive, flowable components into a mixing chamber |
DE7235643U (en) | 1972-09-28 | 1974-06-27 | Fischer A | Femoral head prosthesis |
DE2250501C3 (en) | 1972-10-14 | 1975-04-30 | Artur 7241 Tumlingen Fischer | Fixing means for the socket of a hip joint prosthesis |
US3828779A (en) | 1972-12-13 | 1974-08-13 | Ims Ltd | Flex-o-jet |
US3858582A (en) | 1972-12-13 | 1975-01-07 | Ims Ltd | Cartridge vaccine injector |
US3798982A (en) | 1973-04-25 | 1974-03-26 | Origo | Pump actuator including rotatable cams |
US3850158A (en) | 1973-07-09 | 1974-11-26 | E Elias | Bone biopsy instrument and method |
US3921858A (en) | 1973-11-05 | 1975-11-25 | Robert A Bemm | Automatic confection decorating system |
SE7406449L (en) | 1974-01-08 | 1975-07-09 | Kettenbach Fab Chem A | |
CA1021767A (en) * | 1974-01-11 | 1977-11-29 | Samuel J. Popeil | Orbital whipper having rotatable beaters |
US4115346A (en) | 1974-02-12 | 1978-09-19 | Kulzer & Co. Gmbh | Hydroxy group containing diesters of acrylic acids and their use in dental material |
CH581988A5 (en) | 1974-04-09 | 1976-11-30 | Messerschmitt Boelkow Blohm | |
US3875595A (en) | 1974-04-15 | 1975-04-08 | Edward C Froning | Intervertebral disc prosthesis and instruments for locating same |
US3976073A (en) | 1974-05-01 | 1976-08-24 | Baxter Laboratories, Inc. | Vial and syringe connector assembly |
CH611150A5 (en) | 1975-04-18 | 1979-05-31 | Sulzer Ag | |
US3993250A (en) | 1975-05-19 | 1976-11-23 | Shure Alan H | Apparatus for spraying liquid materials |
JPS51134465A (en) | 1975-05-19 | 1976-11-20 | Multi Supuree Kogyo Kk | A mixing and stirring device |
US4090640A (en) | 1975-07-24 | 1978-05-23 | Smith Ray V | Hot melt adhesive pumping apparatus having pressure-sensitive feedback control |
US4011602A (en) | 1975-10-06 | 1977-03-15 | Battelle Memorial Institute | Porous expandable device for attachment to bone tissue |
US4062274A (en) | 1976-06-07 | 1977-12-13 | Knab James V | Exhaust system for bone cement |
US4105145A (en) | 1976-09-16 | 1978-08-08 | James D. Pauls | Mechanically operated dispensing device |
US4077494A (en) | 1976-12-15 | 1978-03-07 | Parker-Hannifin Corporation | Grease gun |
US4170990A (en) | 1977-01-28 | 1979-10-16 | Fried. Krupp Gesellschaft Mit Beschrankter Haftung | Method for implanting and subsequently removing mechanical connecting elements from living tissue |
DE2724814C3 (en) | 1977-06-02 | 1980-03-27 | Kulzer & Co Gmbh, 6380 Bad Homburg | Preliminary product for the preparation of bone cement |
JPS602368B2 (en) | 1977-06-23 | 1985-01-21 | 三菱電機株式会社 | Laser heating device |
US4180070A (en) | 1977-08-29 | 1979-12-25 | Abbott Laboratories | Disposable double vial syringe |
US4146334A (en) | 1977-09-09 | 1979-03-27 | Richard Farrell | Paint mixing and dispensing apparatus |
US4168787A (en) | 1977-11-18 | 1979-09-25 | Superior, Inc. | Variable stroke fluid lubricant dispenser |
SU662082A1 (en) | 1977-12-09 | 1979-05-15 | Тартуский Ордена Трудового Красного Знамени Государственный Университет | Fixative for treating tubular bone fractures |
IL53703A (en) | 1977-12-28 | 1979-10-31 | Aginsky Yacov | Intramedullary nails |
DE2815699C3 (en) | 1978-04-12 | 1981-12-24 | Jakob Preßl Söhne, 8500 Nürnberg | Grease gun |
DE2821785A1 (en) | 1978-05-18 | 1979-11-22 | Gerhard Dawidowski | Bone fracture compression nail - has distal claw sliding in proximal ones in axial direction, retained by lug |
EP0006414B1 (en) | 1978-06-29 | 1984-10-10 | Osteo Ag | Carbon fiber reinforced bone cement |
JPS559242U (en) * | 1978-07-04 | 1980-01-21 | ||
US4198383A (en) * | 1978-08-21 | 1980-04-15 | Deryagina Galina M | Apparatus for continuous preparation of acrylonitrilebutadienstyrene copolymer |
DE2842839C3 (en) | 1978-10-02 | 1986-11-13 | NATEC Institut für naturwissenschaftlich-technische Dienste GmbH, 2000 Hamburg | Self-hardening compound based on polymethyl methacrylate and its use |
US4198975A (en) | 1978-10-06 | 1980-04-22 | Haller J Gilbert | Self-injecting hypodermic syringe device |
US4257540A (en) | 1978-10-26 | 1981-03-24 | Mcneil Corporation | Hand-held battery-powered grease gun |
IT1194905B (en) | 1979-02-05 | 1988-09-28 | Zoppellari Carlo | DEVICE APPLICABLE PARTICULARLY IN MACHINES FOR THE DISCONTINUOUS PRODUCTION OF ICE CREAM TO OBTAIN THE TOTAL EXPULSION OF THE PRODUCT PROCESSED |
JPS55109440A (en) * | 1979-02-15 | 1980-08-22 | Matsushita Electric Works Ltd | Agitating device of reaction vessel |
US4503673A (en) | 1979-05-25 | 1985-03-12 | Charles Schachle | Wind power generating system |
US4274163A (en) | 1979-07-16 | 1981-06-23 | The Regents Of The University Of California | Prosthetic fixation technique |
US4277184A (en) | 1979-08-14 | 1981-07-07 | Alan Solomon | Disposable orthopedic implement and method |
US4276878A (en) | 1979-08-20 | 1981-07-07 | Karl Storz | Injection syringe |
US4404327A (en) | 1979-10-31 | 1983-09-13 | Crugnola Aldo M | Orthopaedic cement from acrylate polymers |
DE2947875A1 (en) | 1979-11-28 | 1981-06-04 | Hans Dr. 5609 Hückeswagen Reimer | Endoprosthesis anchoring bone cement compsn. - contg. particulate organic material dissolving in body in addn. to monomer and reactive component |
US4338925A (en) | 1979-12-20 | 1982-07-13 | Jo Miller | Pressure injection of bone cement apparatus and method |
SE420009B (en) | 1979-12-21 | 1981-09-07 | Ericsson Telefon Ab L M | EXPANDER SCREW FOR FIXING IN A SPACE |
US4326567A (en) | 1979-12-26 | 1982-04-27 | Vercon Inc. | Variable volume, positive displacement sanitary liquid dispensing machine |
US4341691A (en) | 1980-02-20 | 1982-07-27 | Zimmer, Inc. | Low viscosity bone cement |
US4405249A (en) | 1980-03-28 | 1983-09-20 | National Research Development Corporation | Dispensing apparatus and method |
AT366916B (en) | 1980-04-02 | 1982-05-25 | Immuno Ag | DEVICE FOR APPLICATING A TISSUE ADHESIVE BASED ON HUMAN OR ANIMAL PROTEINS |
CA1146301A (en) | 1980-06-13 | 1983-05-17 | J. David Kuntz | Intervertebral disc prosthesis |
DE3070268D1 (en) | 1980-07-26 | 1985-04-18 | Kurz Karl Heinz | Device for determining the internal dimensions of the uterine cavity |
US4380398A (en) * | 1980-09-16 | 1983-04-19 | Burgess Basil A | Dispersion mixer |
US4346708A (en) | 1981-04-20 | 1982-08-31 | Leveen Harry H | Syringe |
US4409966A (en) | 1981-05-29 | 1983-10-18 | Lambrecht Richard M | Method and apparatus for injecting a substance into the bloodstream of a subject |
GB2099703B (en) | 1981-06-10 | 1985-01-23 | Downs Surgical Ltd | Biopsy needle |
US4487602A (en) | 1981-09-14 | 1984-12-11 | Syntex (U.S.A.) Inc. | Injection device |
US4403989A (en) | 1981-09-14 | 1983-09-13 | Syntex (U.S.A.) Inc. | Injection device |
US4400170A (en) | 1981-09-29 | 1983-08-23 | Syntex (U.S.A.) Inc. | Implanting device and implant magazine |
US4474572A (en) | 1981-09-29 | 1984-10-02 | Syntex (U.S.A.) Inc. | Implanting device and implant magazine |
SU1011119A1 (en) | 1981-10-23 | 1983-04-15 | Edinak Sergej A | Fixator for intraosseous osteosynthesis |
SU1049050A1 (en) | 1982-01-15 | 1983-10-23 | Киевский Медицинский Институт Им.Акад.А.А.Богомольца | Pin for osteosynthesis |
DE3201056C1 (en) | 1982-01-15 | 1983-08-11 | Fried. Krupp Gmbh, 4300 Essen | Intramedullary nail |
US4453539A (en) | 1982-03-01 | 1984-06-12 | The University Of Toledo | Expandable intramedullary nail for the fixation of bone fractures |
US4476866A (en) | 1982-08-06 | 1984-10-16 | Thomas J. Fogarty | Combined large and small bore syringe |
US4595006A (en) | 1982-08-16 | 1986-06-17 | Burke Dennis W | Apparatus for cemented implantation of prostheses |
CH657980A5 (en) | 1982-10-21 | 1986-10-15 | Sulzer Ag | DISPOSABLE BONE CEMENT SYRINGE. |
DE3245956A1 (en) | 1982-12-11 | 1984-06-14 | Beiersdorf Ag, 2000 Hamburg | SURGICAL MATERIAL |
NZ206650A (en) | 1982-12-31 | 1987-05-29 | Phillips Pty Ltd N J | Injector, retractable needle shroud activates piston |
USD279499S (en) | 1983-02-18 | 1985-07-02 | Zimmer, Inc. | Mixing apparatus |
SE434332B (en) | 1983-03-23 | 1984-07-23 | Jan Ingemar Neslund | CELL SAMPLING DEVICE |
US4522200A (en) | 1983-06-10 | 1985-06-11 | Ace Orthopedic Company | Adjustable intramedullar rod |
US4558693A (en) | 1983-08-29 | 1985-12-17 | Harvey Lash | Penile implant |
FR2551350B1 (en) | 1983-09-02 | 1985-10-25 | Buffet Jacques | FLUID INJECTION DEVICE, SUITABLE FOR IMPLANTATION |
FR2552404B1 (en) | 1983-09-26 | 1987-12-24 | Merck Sharp & Dohme | ASSEMBLY FOR PREPARING AND DELIVERING A SOLUTION, SHUTTERING PLUG FOR SUCH ASSEMBLY AND METHOD FOR MANUFACTURING THE SAME |
US4554914A (en) | 1983-10-04 | 1985-11-26 | Kapp John P | Prosthetic vertebral body |
US4593685A (en) | 1983-10-17 | 1986-06-10 | Pfizer Hospital Products Group Inc. | Bone cement applicator |
US4546767A (en) | 1983-10-27 | 1985-10-15 | Smith Carl W | Cement injection device |
DE3474539D1 (en) | 1983-12-02 | 1988-11-17 | Bramlage Gmbh | Dispenser for pasty materials, especially a dispenser for toothpaste |
US4600118A (en) | 1984-02-02 | 1986-07-15 | Martin Gerald D | Ferrule dispenser |
AU562042B2 (en) | 1984-03-24 | 1987-05-28 | Meishintoryo Co. Ltd. | Surgical cement |
CA1227902A (en) | 1984-04-02 | 1987-10-13 | Raymond G. Tronzo | Fenestrated hip screw and method of augmented internal fixation |
US4503169A (en) | 1984-04-19 | 1985-03-05 | Minnesota Mining And Manufacturing Company | Radiopaque, low visual opacity dental composites containing non-vitreous microparticles |
US4728006A (en) | 1984-04-27 | 1988-03-01 | The Procter & Gamble Company | Flexible container including self-sealing dispensing valve to provide automatic shut-off and leak resistant inverted storage |
DE3421157A1 (en) | 1984-06-07 | 1985-12-12 | Ernst Leitz Wetzlar Gmbh, 6330 Wetzlar | PLASTIC-BASED COMPOSITE FOR PROSTHETIC PURPOSES |
DE8420774U1 (en) | 1984-07-11 | 1985-09-12 | Draenert, Klaus, Dr.Med. Dr.Med.Habil., 8000 Muenchen | Device for mixing and applying bone cement |
DE3578375D1 (en) | 1984-09-10 | 1990-08-02 | Draenert Klaus | BONE CEMENT AND METHOD FOR THE PRODUCTION THEREOF. |
US4697584A (en) | 1984-10-12 | 1987-10-06 | Darrel W. Haynes | Device and method for plugging an intramedullary bone canal |
US4686973A (en) | 1984-10-12 | 1987-08-18 | Dow Corning Corporation | Method of making an intramedullary bone plug and bone plug made thereby |
US4650469A (en) | 1984-10-19 | 1987-03-17 | Deltec Systems, Inc. | Drug delivery system |
DE3439322A1 (en) | 1984-10-26 | 1986-05-07 | Infors GmbH, 8000 München | INFUSION PUMP |
DE3443167C2 (en) | 1984-11-27 | 1986-12-18 | orthoplant Endoprothetik GmbH, 2800 Bremen | Surgical cement syringe |
DE3587286T2 (en) | 1984-12-28 | 1993-09-23 | Johnson Matthey Plc | ANTIMICROBIAL COMPOSITIONS. |
US4632101A (en) | 1985-01-31 | 1986-12-30 | Yosef Freedland | Orthopedic fastener |
US4668295A (en) | 1985-04-25 | 1987-05-26 | University Of Dayton | Surgical cements |
US4664298A (en) | 1985-05-01 | 1987-05-12 | Stewart-Warner Corporation | Dual mode grease gun |
GB2174459B (en) | 1985-05-04 | 1988-05-25 | Jencons | Liquid dispensing means |
US4908017A (en) | 1985-05-14 | 1990-03-13 | Ivion Corporation | Failsafe apparatus and method for effecting syringe drive |
ATE50503T1 (en) | 1985-06-20 | 1990-03-15 | Ceraver | CEMENT FOR ANCHORING BONE PROSTHESES. |
AT382783B (en) | 1985-06-20 | 1987-04-10 | Immuno Ag | DEVICE FOR APPLICATING A TISSUE ADHESIVE |
US4670008A (en) | 1985-07-01 | 1987-06-02 | Albertini Beat | High flux threaded needle |
JPH0633375B2 (en) * | 1985-09-19 | 1994-05-02 | バブコツク日立株式会社 | Strainer for coal-water slurry |
GB8524152D0 (en) | 1985-10-01 | 1985-11-06 | Cole Polymers Ltd | Bone cement |
DE3536076A1 (en) | 1985-10-09 | 1987-04-09 | Muehlbauer Ernst Kg | POLYMERIZABLE CEMENT MIXTURES |
GB2182726B (en) | 1985-11-09 | 1989-10-25 | Metal Box Plc | Dispensers for pasty or viscous products |
US4676655A (en) | 1985-11-18 | 1987-06-30 | Isidore Handler | Plunger type cartridge mixer for fluent materials |
SE447785B (en) | 1985-12-23 | 1986-12-15 | Mit Ab | DEVICE FOR APPLIANCES TO ALLOW BENCEMENT MIXING UNDER VACUUM |
JPS62270167A (en) | 1986-01-23 | 1987-11-24 | オマ−ル マホメツド アテイア アル−ラウイ | Disposable syringe aid jig |
US4653487A (en) | 1986-01-29 | 1987-03-31 | Maale Gerhard E | Intramedullary rod assembly for cement injection system |
US4664655A (en) | 1986-03-20 | 1987-05-12 | Norman Orentreich | High viscosity fluid delivery system |
US4758234A (en) | 1986-03-20 | 1988-07-19 | Norman Orentreich | High viscosity fluid delivery system |
DE3609672A1 (en) | 1986-03-21 | 1987-09-24 | Klaus Draenert | EVACUABLE BONE CEMENT SYRINGE |
US4961647A (en) | 1986-04-04 | 1990-10-09 | Dhd Medical Products | Orthopedic cement mixer |
DE3613213A1 (en) | 1986-04-18 | 1987-10-22 | Merck Patent Gmbh | TRICALCIUMPHOSPHATE FOR IMPLANTATION MATERIALS |
DE3765472D1 (en) | 1986-07-07 | 1990-11-15 | Wilhelm A Keller | DISCHARGE DEVICE FOR OPERATING CARTRIDGES. |
US4737151A (en) | 1986-07-25 | 1988-04-12 | Clement John G | Syringe injector |
US4767033A (en) | 1986-07-31 | 1988-08-30 | The Drackett Company | Manually operated gear pump spray head |
US4704035A (en) * | 1986-10-06 | 1987-11-03 | Baker Perkins, Inc. | Remotely transmitting batch mixer |
US5024232A (en) | 1986-10-07 | 1991-06-18 | The Research Foundation Of State University Of Ny | Novel radiopaque heavy metal polymer complexes, compositions of matter and articles prepared therefrom |
US4710179A (en) | 1986-10-27 | 1987-12-01 | Habley Medical Technology Corporation | Snap-on vernier syringe |
US4697929A (en) * | 1986-10-28 | 1987-10-06 | Charles Ross & Son Company | Planetary mixers |
FR2606282B1 (en) | 1986-11-12 | 1994-05-20 | Ecole Nale Sup Ceramique Indle | CURABLE COMPOSITION FOR FILLING BONE CAVITIES |
US5051482A (en) | 1986-11-19 | 1991-09-24 | Laboratorium Fur Experimentelle Chirurgie | Method and apparatus for preparing a self-curing two-component powder liquid bone cement |
IL80731A0 (en) | 1986-11-23 | 1987-02-27 | Bron Dan | Hydraulic syringe pump |
DE3642212A1 (en) | 1986-12-10 | 1988-06-23 | Espe Stiftung | POLYMERIZABLE MEASURES, METHOD FOR THEIR PRODUCTION AND THEIR USE AS DENTAL MEASURES |
US4762515A (en) | 1987-01-06 | 1988-08-09 | Ivy Laboratories, Inc. | Medicament implant applicator |
CH671691A5 (en) | 1987-01-08 | 1989-09-29 | Sulzer Ag | |
DE3701190A1 (en) | 1987-01-16 | 1988-07-28 | Ziemann Edeltraud | DEVICE FOR EJECTING OR SUCTIONING LIQUID OR PASTOES MEDIA |
CH671525A5 (en) * | 1987-01-22 | 1989-09-15 | Inst Mek Akademii Nauk Sssr | |
JPS63194722A (en) * | 1987-02-06 | 1988-08-11 | インステイツウト プロブレム メハニキアカデミイ ナウク エスエスエスア−ル | Apparatus for mixing heterogenous substance |
CA1283501C (en) | 1987-02-12 | 1991-04-30 | Thomas P. Hedman | Artificial spinal disc |
DE3705741A1 (en) | 1987-02-23 | 1988-09-01 | Hilti Ag | DISPENSING DEVICE FOR FLOWABLE MEASURES |
US4813870A (en) | 1987-03-09 | 1989-03-21 | Minnesota Mining And Manufacturing Company | Dispenser for viscous liquids |
CH669080GA3 (en) | 1987-05-14 | 1989-02-28 | ||
US4935029A (en) | 1987-06-22 | 1990-06-19 | Matsutani Seisakusho Co., Ltd. | Surgical needle |
WO1988010129A1 (en) | 1987-06-25 | 1988-12-29 | Nova Medical Pty. Limited | Slow delivery injection device |
US4792577A (en) | 1987-07-16 | 1988-12-20 | Johnson & Johnson Consumer Products, Inc. | Stain-resistant no-mix orthodontic adhesive |
US4860927A (en) | 1987-07-29 | 1989-08-29 | Grinde James E | Blow molded two-compartment container |
US5258420A (en) | 1987-07-30 | 1993-11-02 | Pfizer Hospital Products Group, Inc. | Bone cement for sustained release of substances |
US4900546A (en) | 1987-07-30 | 1990-02-13 | Pfizer Hospital Products Group, Inc. | Bone cement for sustained release of substances |
US4863072A (en) | 1987-08-18 | 1989-09-05 | Robert Perler | Single hand operable dental composite package |
US4978336A (en) | 1987-09-29 | 1990-12-18 | Hemaedics, Inc. | Biological syringe system |
DK517887D0 (en) | 1987-10-02 | 1987-10-02 | Westergaard Knud Erik | MULTI-FUNCTION SET FOR PRINTING LIQUID |
US4815454A (en) | 1987-11-16 | 1989-03-28 | Dozier Jr John K | Apparatus and method for injecting bone cement |
US5037473A (en) | 1987-11-18 | 1991-08-06 | Antonucci Joseph M | Denture liners |
GB8727166D0 (en) | 1987-11-20 | 1987-12-23 | Stewart K | Creating inflatable products |
US4837279A (en) | 1988-02-22 | 1989-06-06 | Pfizer Hospital Products Corp, Inc. | Bone cement |
DE3806448A1 (en) | 1988-02-29 | 1989-09-07 | Espe Stiftung | COMPATIBLE MATERIAL AND MATERIALS AVAILABLE THEREFROM |
US5019041A (en) | 1988-03-08 | 1991-05-28 | Scimed Life Systems, Inc. | Balloon catheter inflation device |
US4946077A (en) | 1988-03-11 | 1990-08-07 | Olsen Laverne R | In-line air-bleed valve for hand-operated grease guns |
FR2629337A1 (en) | 1988-03-30 | 1989-10-06 | Bigan Michel | Device for intra-osseus sealing of a prosthesis element |
US4854312A (en) | 1988-04-13 | 1989-08-08 | The University Of Toledo | Expanding intramedullary nail |
DE3817101C2 (en) | 1988-05-19 | 1998-05-20 | Axel Von Brand | Device for transferring liquid from one container to another container |
IT1234978B (en) | 1988-06-01 | 1992-06-09 | Tecres Spa | TWO-STAGE CEMENTITIOUS MIXTURE, PARTICULARLY SUITABLE FOR ORTHOPEDIC USES. |
DE3820498A1 (en) | 1988-06-16 | 1989-12-21 | Bayer Ag | DENTAL MATERIALS |
CA1333209C (en) | 1988-06-28 | 1994-11-29 | Gary Karlin Michelson | Artificial spinal fusion implants |
DE3824886A1 (en) * | 1988-07-22 | 1990-01-25 | Janke & Kunkel Kg | VERTICAL STIRRING AND / OR KNEWING MACHINE WITH ROTATING BEARING GEARBOX |
US5012413A (en) | 1988-07-27 | 1991-04-30 | Pandrol Jackson, Inc. | Railroad track curve lining apparatus and method |
US4910259A (en) | 1988-09-26 | 1990-03-20 | Wolff & Kaaber A/S | Bone cement |
US4968303A (en) | 1988-09-27 | 1990-11-06 | Eli Lilly And Company | Hypodermic syringe holder |
SE462012B (en) | 1988-09-27 | 1990-04-30 | Electrolux Ab | VACUUM CLEANER |
JPH02122017A (en) | 1988-10-31 | 1990-05-09 | Toshiba Corp | Apparatus for removing strain of square cylindrical deep drawing product |
FR2638359A1 (en) | 1988-11-03 | 1990-05-04 | Tino Dalto | SYRINGE GUIDE WITH ADJUSTMENT OF DEPTH DEPTH OF NEEDLE IN SKIN |
US4944726A (en) | 1988-11-03 | 1990-07-31 | Applied Vascular Devices | Device for power injection of fluids |
DE3838465A1 (en) | 1988-11-12 | 1990-05-17 | Fresenius Ag | SYRINGE PUMP |
FR2638972B1 (en) | 1988-11-14 | 1990-12-14 | Osteal Medical Laboratoires | CEMENT FOR FIXING BONE PROSTHESES |
JPH02166235A (en) | 1988-12-19 | 1990-06-26 | Kawasaki Steel Corp | Method for controlling sheet temperature in metallic sheet heating furnace |
US4973168A (en) | 1989-01-13 | 1990-11-27 | Chan Kwan Ho | Vacuum mixing/bone cement cartridge and kit |
CH677202A5 (en) | 1989-01-16 | 1991-04-30 | Maag Zahnraeder & Maschinen Ag | |
US4969888A (en) | 1989-02-09 | 1990-11-13 | Arie Scholten | Surgical protocol for fixation of osteoporotic bone using inflatable device |
US5131382A (en) | 1989-03-27 | 1992-07-21 | Meyer William F | Endoscopic percutaneous discectomy device |
JPH0534760Y2 (en) * | 1989-03-28 | 1993-09-02 | ||
US5059199A (en) | 1989-04-12 | 1991-10-22 | Olympus Optical Co., Ltd. | Treating device for endoscopes |
US5018919A (en) | 1989-04-15 | 1991-05-28 | Bergwerksverband Gmbh | Combined rigid profile and stretching roof bolt with expansion element |
US5015233A (en) | 1989-04-17 | 1991-05-14 | Freedom Machine, Inc. | Pneumatic inflation device |
SE462315B (en) | 1989-05-03 | 1990-06-11 | Surgitec Ab | DEVICE FOR MANUFACTURING BENCEMENT |
CA2007210C (en) | 1989-05-10 | 1996-07-09 | Stephen D. Kuslich | Intervertebral reamer |
DK235589D0 (en) | 1989-05-12 | 1989-05-12 | Wolff & Kaaber | METHOD AND APPARATUS FOR MIXING A SOLID AND LIQUID COMPONENT |
JPH0645487B2 (en) | 1989-05-19 | 1994-06-15 | 徳山曹達株式会社 | Curing material |
DE3919534A1 (en) | 1989-06-15 | 1990-12-20 | Merck Patent Gmbh | METHOD AND DEVICE FOR PREPARING BONE CEMENT |
EP0405556B1 (en) | 1989-06-30 | 1996-05-22 | TDK Corporation | Living hard tissue replacement, its preparation, and preparation of integral body |
US4973301A (en) | 1989-07-11 | 1990-11-27 | Israel Nissenkorn | Catheter and method of using same |
US6004330A (en) | 1989-08-16 | 1999-12-21 | Medtronic, Inc. | Device or apparatus for manipulating matter |
JPH0390237A (en) | 1989-08-31 | 1991-04-16 | Matsutani Seisakusho Co Ltd | Working method for eyeless suture needle |
US4994029A (en) | 1989-09-12 | 1991-02-19 | David Bull Laboratories Pty. Ltd. | Syringe mixer and injector device |
US5116335A (en) | 1989-09-18 | 1992-05-26 | Hannon Gerard T | Intramedullary hybrid nail and instrumentation for installation and removal |
US5318532A (en) | 1989-10-03 | 1994-06-07 | C. R. Bard, Inc. | Multilumen catheter with variable cross-section lumens |
US5035706A (en) | 1989-10-17 | 1991-07-30 | Cook Incorporated | Percutaneous stent and method for retrieval thereof |
CA2027921C (en) | 1989-10-19 | 1997-12-09 | Nobuo Nakabayashi | Bone cement composition, cured product thereof, implant material and process for the preparation of the same |
US5295980A (en) | 1989-10-30 | 1994-03-22 | Ersek Robert A | Multi-use cannula system |
DE3936703A1 (en) | 1989-11-03 | 1991-05-08 | Lutz Biedermann | BONE SCREW |
US5059193A (en) | 1989-11-20 | 1991-10-22 | Spine-Tech, Inc. | Expandable spinal implant and surgical method |
US5074871A (en) | 1989-12-07 | 1991-12-24 | Evi Corporation | Catheter atherotome |
CH680564A5 (en) | 1989-12-07 | 1992-09-30 | Experimentelle Chirurgie Schwe | |
IT1236864B (en) | 1989-12-29 | 1993-04-22 | Tecres Spa | PROCEDURE FOR MIXING AND ADMINISTRATING A TWO-PART BONE CONCRETE DIRECTLY ON THE SPOT, AND DEVICE THAT REALIZES IT |
US5435645A (en) | 1989-12-29 | 1995-07-25 | Tecres Spa | Process and apparatus for the mixing and direct emplacement of a two-component bone cement |
ES2064990T3 (en) | 1990-01-08 | 1995-02-01 | Becton Dickinson France | STORAGE AND TRANSFER BOTTLE WITH DOUBLE COMPARTMENT. |
US5022563A (en) | 1990-01-10 | 1991-06-11 | Electron Fusion Devices, Inc. | Dispenser-gun assembly for viscous fluids and dispenser therefor |
US5112333A (en) | 1990-02-07 | 1992-05-12 | Fixel Irving E | Intramedullary nail |
DE4104092A1 (en) | 1990-02-13 | 1991-08-14 | Christoph Dr Med Rieger | Metal cannula enclosed in outer cannula of flexible plastics - has circumferential slots in wall to increase flexibility |
DE4004678A1 (en) | 1990-02-15 | 1991-08-22 | Bayer Ag | FILLERS, SWELLABLE PEARL POLYMERISATES |
US5454365A (en) | 1990-11-05 | 1995-10-03 | Bonutti; Peter M. | Mechanically expandable arthroscopic retractors |
US4946285A (en) * | 1990-03-08 | 1990-08-07 | Hobart Corporation | Bowl scraper attachment for planetary food mixer |
US5071040A (en) | 1990-03-09 | 1991-12-10 | Pfizer Hospital Products Group, Inc. | Surgical adhesives mixing and dispensing implement |
DD293485A5 (en) | 1990-04-10 | 1991-09-05 | Uwe Fuhrmann,De | INTRAMEDULLAERE OSTEOSYNTHESESPINDEL |
FR2661914B1 (en) | 1990-05-11 | 1994-05-06 | Essilor Internal Cie Gle Optique | METHOD FOR MANUFACTURING A TRANSPARENT POLYMER LENS WITH MODULATED REFRACTION INDEX. |
DE4019617A1 (en) | 1990-06-20 | 1992-01-02 | Thera Ges Fuer Patente | IMPLANTABLE ACTIVE SUBSTITUTE MATERIAL |
US5236445A (en) | 1990-07-02 | 1993-08-17 | American Cyanamid Company | Expandable bone anchor and method of anchoring a suture to a bone |
DE69120177T2 (en) | 1990-09-10 | 1996-10-10 | Synthes Ag | Bone regeneration membrane |
US6080801A (en) | 1990-09-13 | 2000-06-27 | Klaus Draenert | Multi-component material and process for its preparation |
US5702448A (en) | 1990-09-17 | 1997-12-30 | Buechel; Frederick F. | Prosthesis with biologically inert wear resistant surface |
US5725529A (en) | 1990-09-25 | 1998-03-10 | Innovasive Devices, Inc. | Bone fastener |
WO1992004874A1 (en) | 1990-09-25 | 1992-04-02 | Nicholson Associates, Inc. | Bone fastener |
US5108016A (en) | 1990-10-04 | 1992-04-28 | Waring Roy F | Fuel container system |
US5108403A (en) | 1990-11-09 | 1992-04-28 | Stern Mark S | Bone waxing device |
US5102413A (en) | 1990-11-14 | 1992-04-07 | Poddar Satish B | Inflatable bone fixation device |
CS277533B6 (en) | 1990-12-29 | 1993-03-17 | Krajicek Milan | Fixed osteaosynthesis appliance |
GB9100097D0 (en) | 1991-01-04 | 1991-02-20 | Sec Dep For Health The | Biocompatible mouldable polymeric material |
US5354287A (en) | 1991-01-16 | 1994-10-11 | Senetek Plc | Injector for delivering fluid to internal target tissue |
US5123926A (en) | 1991-02-22 | 1992-06-23 | Madhavan Pisharodi | Artificial spinal prosthesis |
US5171278A (en) | 1991-02-22 | 1992-12-15 | Madhavan Pisharodi | Middle expandable intervertebral disk implants |
CA2104391C (en) | 1991-02-22 | 2006-01-24 | Madhavan Pisharodi | Middle expandable intervertebral disk implant and method |
US5171248A (en) | 1991-02-27 | 1992-12-15 | Intermedics Orthopedics, Inc. | Medullary caliper |
US5190191A (en) | 1991-03-13 | 1993-03-02 | Reyman Mark E | Apparatus for measured and unmeasured dispensing of viscous fluids |
FR2674119B1 (en) | 1991-03-22 | 1993-06-18 | Fixano Productions | DEVICE FOR GUIDING THE SLIDING OF OSTEOSYNTHESIS SCREWS FOR INTRA-CAPSULAR FRACTURE OF THE FEMUR'S NECK. |
US5192327A (en) | 1991-03-22 | 1993-03-09 | Brantigan John W | Surgical prosthetic implant for vertebrae |
JPH04329956A (en) | 1991-04-30 | 1992-11-18 | Takeda Chem Ind Ltd | Germ-free holding/mixing apparatus for medicine held in individual sealed container |
EP0511868B1 (en) | 1991-05-01 | 1996-09-25 | Chichibu Onoda Cement Corporation | Medical or dental hardening compositions |
US5160327A (en) | 1991-05-31 | 1992-11-03 | Vance Products Incorporated | Rotational pressure drive for a medical syringe |
DE4118884A1 (en) * | 1991-06-07 | 1992-12-10 | List Ag | MIXING kneader |
US5591172A (en) | 1991-06-14 | 1997-01-07 | Ams Medinvent S.A. | Transluminal implantation device |
US5199419A (en) | 1991-08-05 | 1993-04-06 | United States Surgical Corporation | Surgical retractor |
US5630806A (en) | 1991-08-13 | 1997-05-20 | Hudson International Conductors | Spiral wrapped medical tubing |
IL102941A0 (en) | 1991-08-27 | 1993-01-31 | Thomas R Johnson | Injection syringe |
US5431654A (en) | 1991-09-30 | 1995-07-11 | Stryker Corporation | Bone cement injector |
US5265956A (en) | 1991-09-30 | 1993-11-30 | Stryker Corporation | Bone cement mixing and loading apparatus |
US5203773A (en) * | 1991-10-18 | 1993-04-20 | United States Surgical Corporation | Tissue gripping apparatus for use with a cannula or trocar assembly |
SE510490C2 (en) | 1992-02-07 | 1999-05-31 | Scandimed International Ab | Process for producing bone cement and apparatus for carrying out the process |
US5219897A (en) | 1992-02-10 | 1993-06-15 | Murray William M | Dental and orthopedic cement method and preforms |
US5336699A (en) | 1992-02-20 | 1994-08-09 | Orthopaedic Research Institute | Bone cement having chemically joined reinforcing fillers |
US5217147A (en) | 1992-03-09 | 1993-06-08 | Kaufman Products Inc. | Liquid dispenser with compression chamber |
US5328362A (en) | 1992-03-11 | 1994-07-12 | Watson Sherman L | Soft resilient interocclusal dental appliance, method of forming same and composition for same |
US5242983A (en) | 1992-03-19 | 1993-09-07 | Edison Polymer Innovation Corporation | Polyisobutylene toughened poly(methyl methacrylate) |
SE470177B (en) | 1992-03-23 | 1993-11-29 | Radi Medical Systems | Device for punching in hard tissue and puncture needle |
US5637097A (en) | 1992-04-15 | 1997-06-10 | Yoon; Inbae | Penetrating instrument having an expandable anchoring portion |
CH686933A5 (en) * | 1992-04-15 | 1996-08-15 | Fischer Georg Giessereianlagen | Apparatus for mixing and preparation of free-flowing materials. |
US5707362A (en) | 1992-04-15 | 1998-01-13 | Yoon; Inbae | Penetrating instrument having an expandable anchoring portion for triggering protrusion of a safety member and/or retraction of a penetrating member |
US5269762A (en) | 1992-04-21 | 1993-12-14 | Sterling Winthrop, Inc. | Portable hand-held power assister device |
FR2690332A1 (en) | 1992-04-28 | 1993-10-29 | Loutfi Rachid | Surgical instrument for injection of bone material into spine - has cylindrical body forming circular-section channel, housing rotary cylinder with endless screw surface driving bone material to outlet |
JPH05317383A (en) | 1992-05-19 | 1993-12-03 | Nissho Corp | Solution container equipped with means for communicating with chemical container |
US5501695A (en) | 1992-05-27 | 1996-03-26 | The Anspach Effort, Inc. | Fastener for attaching objects to bones |
US5334184A (en) | 1992-06-30 | 1994-08-02 | Bimman Lev A | Apparatus for intramedullary fixation broken bones |
GB2268068B (en) | 1992-07-01 | 1996-08-21 | John Bruce Clayfield Davies | Devices having expansion means for securing end portions of tubular members |
JP2660641B2 (en) | 1992-07-22 | 1997-10-08 | 株式会社東洋設計 | Material winding mechanism of roll kneader |
US5334626A (en) | 1992-07-28 | 1994-08-02 | Zimmer, Inc. | Bone cement composition and method of manufacture |
US5531683A (en) | 1992-08-13 | 1996-07-02 | Science Incorporated | Mixing and delivery syringe assembly |
US5395590A (en) | 1992-09-04 | 1995-03-07 | Swaniger; James R. | Valved container lid |
US5257632A (en) | 1992-09-09 | 1993-11-02 | Symbiosis Corporation | Coaxial bone marrow biopsy coring and aspirating needle assembly and method of use thereof |
US5254092A (en) | 1992-09-15 | 1993-10-19 | American Medical Systems, Inc. | Fluid flow check valve |
DE9213656U1 (en) | 1992-10-09 | 1992-12-03 | Angiomed Ag, 7500 Karlsruhe, De | |
US5356382A (en) | 1992-10-23 | 1994-10-18 | Applied Medical Research, Inc. | Percutaneous tract measuring and forming device |
GB9224573D0 (en) | 1992-11-21 | 1993-01-13 | Klinge Erwin L | Expanding intramedullary nail |
US5372583A (en) | 1992-11-25 | 1994-12-13 | Cardiopulmonary Specialities, Inc. | Bone marrow infuser and method of use |
US5331972A (en) | 1992-12-03 | 1994-07-26 | Baxter International Inc. | Bone marrow biopsy, aspiration and transplant needles |
US5375583A (en) | 1992-12-14 | 1994-12-27 | Ford Motor Company | Adaptive closed-loop electronic fuel control system with fuel puddling compensation |
EP0625917B1 (en) | 1992-12-15 | 1998-03-25 | Sanofi | Device for preparing a medicinal substance solution, suspension or emulsion |
US5527276A (en) | 1993-01-12 | 1996-06-18 | Arthroscopic Assistants, Inc. | Flexible inflow/outflow cannula |
US5398483A (en) | 1993-01-29 | 1995-03-21 | Polymers Reconstructive A/S | Method and apparatus for packaging, mixing and delivering bone cement |
US5370221A (en) | 1993-01-29 | 1994-12-06 | Biomet, Inc. | Flexible package for bone cement components |
JPH06239352A (en) | 1993-02-05 | 1994-08-30 | Nissho Corp | Solution injection set |
US5441502A (en) | 1993-02-17 | 1995-08-15 | Mitek Surgical Products, Inc. | System and method for re-attaching soft tissue to bone |
DE4305376C1 (en) | 1993-02-22 | 1994-09-29 | Wolf Gmbh Richard | Medical instrument shaft |
US5431676A (en) | 1993-03-05 | 1995-07-11 | Innerdyne Medical, Inc. | Trocar system having expandable port |
DE4310796C2 (en) | 1993-04-05 | 1996-01-25 | Reburg Patentverwertungs Gmbh | Expansion anchor |
US5534028A (en) | 1993-04-20 | 1996-07-09 | Howmedica, Inc. | Hydrogel intervertebral disc nucleus with diminished lateral bulging |
US5411180A (en) | 1993-05-07 | 1995-05-02 | Innovative Technology Sales, Inc. | Self-contained hydraulic dispensing mechanism with pressure relief regulator |
DE4315757C1 (en) | 1993-05-11 | 1994-11-10 | Plus Endoprothetik Ag | Vertebral implant |
US5558639A (en) | 1993-06-10 | 1996-09-24 | Gangemi; Ronald J. | Ambulatory patient infusion apparatus |
CA2521196C (en) | 1993-06-10 | 2007-04-17 | Karlin Technology, Inc. | Bone removal device for use in performing spinal surgery |
US5443182A (en) | 1993-06-11 | 1995-08-22 | Tanaka; Kazuna | Methods and apparatus for preparing and delivering bone cement |
FR2706309B1 (en) | 1993-06-17 | 1995-10-06 | Sofamor | Instrument for surgical treatment of an intervertebral disc by the anterior route. |
US5531519A (en) | 1993-07-06 | 1996-07-02 | Earle; Michael L. | Automated bone cement mixing apparatus |
AU7324394A (en) | 1993-07-06 | 1995-02-06 | Michael L. Earle | Bone cement delivery gun |
DE4323034C1 (en) | 1993-07-09 | 1994-07-28 | Lutz Biedermann | Placeholders, especially for an intervertebral disc |
US5763092A (en) | 1993-09-15 | 1998-06-09 | Etex Corporation | Hydroxyapatite coatings and a method of their manufacture |
DE4332307C1 (en) | 1993-09-23 | 1994-09-29 | Heraeus Kulzer Gmbh | Syringe for the metered dispensing of viscous materials, especially of dental materials |
US5423850A (en) | 1993-10-01 | 1995-06-13 | Berger; J. Lee | Balloon compressor for internal fixation of bone fractures |
US5395326A (en) | 1993-10-20 | 1995-03-07 | Habley Medical Technology Corporation | Pharmaceutical storage and mixing syringe having high pressure assisted discharge |
US5573265A (en) | 1993-11-05 | 1996-11-12 | Fichtel & Sachs Ag | Stabilizer system for a motor vehicle suspension system with a rotary actuator |
US5368386A (en) * | 1993-11-16 | 1994-11-29 | Murray; William M. | Manual bone cement mixing device |
FR2712486A1 (en) | 1993-11-19 | 1995-05-24 | Breslave Patrice | Intervertebral prosthesis |
US5514137A (en) | 1993-12-06 | 1996-05-07 | Coutts; Richard D. | Fixation of orthopedic devices |
DE9319007U1 (en) | 1993-12-10 | 1995-04-06 | Muehlbauer Ernst | Storage syringe for viscous dental materials |
US6241734B1 (en) | 1998-08-14 | 2001-06-05 | Kyphon, Inc. | Systems and methods for placing materials into bone |
US6248110B1 (en) | 1994-01-26 | 2001-06-19 | Kyphon, Inc. | Systems and methods for treating fractured or diseased bone using expandable bodies |
US6716216B1 (en) | 1998-08-14 | 2004-04-06 | Kyphon Inc. | Systems and methods for treating vertebral bodies |
US7044954B2 (en) | 1994-01-26 | 2006-05-16 | Kyphon Inc. | Method for treating a vertebral body |
US20060100635A1 (en) | 1994-01-26 | 2006-05-11 | Kyphon, Inc. | Inflatable device for use in surgical protocol relating to fixation of bone |
JP3333211B2 (en) | 1994-01-26 | 2002-10-15 | レイリー,マーク・エイ | Improved expandable device for use in a surgical method for bone treatment |
ES2287635T3 (en) | 1994-01-26 | 2007-12-16 | Kyphon Inc. | IMPROVED FLAMMABLE DEVICE FOR USE IN SURGICAL METHODS RELATED TO BONE FIXATION. |
US5558136A (en) | 1994-01-31 | 1996-09-24 | Stryker Corporation | Bone cement cartridge with secondary piston |
US5468245A (en) | 1994-02-03 | 1995-11-21 | Vargas, Iii; Joseph H. | Biomedical cement bonding enhancer |
GB9403362D0 (en) * | 1994-02-22 | 1994-04-13 | Summit Medical Ltd | Bone cement mixing apparatus |
AT400304B (en) | 1994-02-28 | 1995-12-27 | Immuno Ag | DEVICE FOR APPLICATING A MULTI-COMPONENT TISSUE ADHESIVE |
US5522816A (en) | 1994-03-09 | 1996-06-04 | Acromed Corporation | Transverse connection for spinal column corrective devices |
US5620458A (en) | 1994-03-16 | 1997-04-15 | United States Surgical Corporation | Surgical instruments useful for endoscopic spinal procedures |
US5697977A (en) | 1994-03-18 | 1997-12-16 | Pisharodi; Madhavan | Method and apparatus for spondylolisthesis reduction |
US5456267A (en) | 1994-03-18 | 1995-10-10 | Stark; John G. | Bone marrow harvesting systems and methods and bone biopsy systems and methods |
DE4409610C3 (en) | 1994-03-21 | 2001-09-20 | Scandimed Internat Ab Sjoebo | Mixing device |
GB9407135D0 (en) | 1994-04-11 | 1994-06-01 | Aberdeen University And Plasma | Treatment of osteoporosis |
US5571189A (en) | 1994-05-20 | 1996-11-05 | Kuslich; Stephen D. | Expandable fabric implant for stabilizing the spinal motion segment |
US5683451A (en) | 1994-06-08 | 1997-11-04 | Cardiovascular Concepts, Inc. | Apparatus and methods for deployment release of intraluminal prostheses |
US5501374A (en) | 1994-06-17 | 1996-03-26 | Vital Products, Co. | Device for extruding high viscosity fluid having multiple modes of operation |
WO1995035064A1 (en) | 1994-06-20 | 1995-12-28 | Slotman Gus J | Tissue spreading surgical instrument |
EP0692235A1 (en) | 1994-07-14 | 1996-01-17 | International Medication Systems (U.K.) Ltd. | Mixing & dispensing apparatus |
DE4425218A1 (en) | 1994-07-16 | 1996-01-18 | Merck Patent Gmbh | Device for mixing and discharging bone cement |
FR2722679A1 (en) | 1994-07-25 | 1996-01-26 | Daniel Felman | Expansible arthrodesis implant for insertion between vertebrae |
US6075067A (en) | 1994-08-15 | 2000-06-13 | Corpipharm Gmbh & Co | Cement for medical use, method for producing the cement, and use of the cement |
US5526853A (en) | 1994-08-17 | 1996-06-18 | Mcgaw, Inc. | Pressure-activated medication transfer system |
DK0777503T3 (en) | 1994-08-19 | 2000-03-20 | Biomat Bv | Radiopaque polymers and processes for their preparation |
US5588745A (en) | 1994-09-02 | 1996-12-31 | Howmedica | Methods and apparatus for mixing bone cement components using an evacuated mixing chamber |
US5536262A (en) | 1994-09-07 | 1996-07-16 | Cedars-Sinai Medical Center | Medical coupling device |
US5562736A (en) | 1994-10-17 | 1996-10-08 | Raymedica, Inc. | Method for surgical implantation of a prosthetic spinal disc nucleus |
JPH10507090A (en) | 1994-10-20 | 1998-07-14 | インステント インコーポレーテッド | Cystoscope delivery system |
JPH08126683A (en) | 1994-10-31 | 1996-05-21 | Fujisawa Pharmaceut Co Ltd | Container for transfusion |
US5697932A (en) | 1994-11-09 | 1997-12-16 | Osteonics Corp. | Bone graft delivery system and method |
RO116784B1 (en) | 1994-12-14 | 2001-06-29 | Inst Politehnic Iasi | Double planet stirrer |
US5836306A (en) | 1994-12-23 | 1998-11-17 | Bard Connaught | Exchange accessory for use with a monorail catheter |
DK0800361T3 (en) | 1994-12-28 | 1999-11-08 | Omrix Biopharm Sa | Device for applying one or more fluids |
US5450924A (en) | 1995-01-05 | 1995-09-19 | Tseng; Tien-Tsai | Portable oil suction device |
US5653686A (en) | 1995-01-13 | 1997-08-05 | Coulter Corporation | Closed vial transfer method and system |
GB0102529D0 (en) | 2001-01-31 | 2001-03-21 | Thales Optronics Staines Ltd | Improvements relating to thermal imaging cameras |
WO1996026869A1 (en) | 1995-02-27 | 1996-09-06 | James Owen Camm | Dual material dispenser comprising two containers in head to tail arrangement |
JPH08245329A (en) | 1995-03-13 | 1996-09-24 | G C:Kk | Relining material for denture base |
US5785682A (en) | 1995-03-22 | 1998-07-28 | Abbott Laboratories | Pre-filled syringe drug delivery system |
US5520690A (en) | 1995-04-13 | 1996-05-28 | Errico; Joseph P. | Anterior spinal polyaxial locking screw plate assembly |
ES2153107T3 (en) | 1995-04-21 | 2001-02-16 | Gerd Werding | KEY FOR FIXING THE POSITION AND THE FORM OF FRACTURED ROD BONES. |
US6103779A (en) | 1995-04-26 | 2000-08-15 | Reinforced Polmers, Inc. | Method of preparing molding compositions with fiber reinforcement and products obtained therefrom |
US5747553A (en) | 1995-04-26 | 1998-05-05 | Reinforced Polymer Inc. | Low pressure acrylic molding composition with fiber reinforcement |
US5578035A (en) | 1995-05-16 | 1996-11-26 | Lin; Chih-I | Expandable bone marrow cavity fixation device |
US5549381A (en) | 1995-05-19 | 1996-08-27 | Hays; Greta J. | Method and apparatus for mixing polymeric bone cement components |
US5634880A (en) | 1995-05-22 | 1997-06-03 | Johnson & Johnson Medical, Inc. | Endoscope pressure equalization system and method |
DE19519101B4 (en) | 1995-05-24 | 2009-04-23 | Harms, Jürgen, Prof. Dr. | Height adjustable vertebral body replacement |
GB9510917D0 (en) | 1995-05-30 | 1995-07-26 | Depuy Int Ltd | Bone cavity sealing assembly |
JPH08322848A (en) | 1995-06-01 | 1996-12-10 | Masato Narushima | Screw device for fixing bone fracture part |
US5795922A (en) | 1995-06-06 | 1998-08-18 | Clemson University | Bone cement composistion containing microencapsulated radiopacifier and method of making same |
US6409972B1 (en) | 1995-06-06 | 2002-06-25 | Kwan-Ho Chan | Prepackaged liquid bone cement |
US5660186A (en) | 1995-06-07 | 1997-08-26 | Marshfield Clinic | Spiral biopsy stylet |
US5556201A (en) * | 1995-07-21 | 1996-09-17 | Middleby Marshall Inc. | Bowl scraper for commercial or industrial size food mixers |
US5836914A (en) | 1995-09-15 | 1998-11-17 | Becton Dickinson And Company | Method and apparatus for variably regulating the length of a combined spinal-epidural needle |
US5893488A (en) | 1995-09-18 | 1999-04-13 | Bristol-Myers Squibb Co. | Bone cement injector gun |
US5638997A (en) | 1995-09-18 | 1997-06-17 | Zimmer, Inc. | Bone cement injector gun |
US5797678A (en) * | 1995-09-25 | 1998-08-25 | Murray; William M. | Bone cement mixing device and method |
US5624184A (en) | 1995-10-10 | 1997-04-29 | Chan; Kwan-Ho | Bone cement preparation kit having a breakable mixing shaft forming an output port |
US5782830A (en) | 1995-10-16 | 1998-07-21 | Sdgi Holdings, Inc. | Implant insertion device |
US6217581B1 (en) | 1995-10-18 | 2001-04-17 | John Thomas Tolson | High pressure cement injection device for bone repair |
US5782713A (en) | 1995-12-06 | 1998-07-21 | Yang; Shu-Chiung C. | Bicycle gear crank arresting device |
FR2741256A1 (en) | 1995-11-21 | 1997-05-23 | Advanced Technical Fabrication | CENTROMEDULAR NAIL |
US6228082B1 (en) | 1995-11-22 | 2001-05-08 | Arthrocare Corporation | Systems and methods for electrosurgical treatment of vascular disorders |
US5752974A (en) | 1995-12-18 | 1998-05-19 | Collagen Corporation | Injectable or implantable biomaterials for filling or blocking lumens and voids of the body |
US5766253A (en) | 1996-01-16 | 1998-06-16 | Surgical Dynamics, Inc. | Spinal fusion device |
WO1997028835A1 (en) | 1996-02-05 | 1997-08-14 | Volker Lang | Medicament application device for syringe pumps |
US5814022A (en) | 1996-02-06 | 1998-09-29 | Plasmaseal Llc | Method and apparatus for applying tissue sealant |
US5800389A (en) | 1996-02-09 | 1998-09-01 | Emx, Inc. | Biopsy device |
US5779356A (en) | 1996-02-21 | 1998-07-14 | Chan; Kwan-Ho | Apparatus and method for mixing first and second components of a bone cement in a vacuum |
US5885258A (en) | 1996-02-23 | 1999-03-23 | Memory Medical Systems, Inc. | Medical instrument with slotted memory metal tube |
CA2192520A1 (en) | 1996-03-05 | 1997-09-05 | Ian M. Penn | Expandable stent and method for delivery of same |
US5800550A (en) | 1996-03-13 | 1998-09-01 | Sertich; Mario M. | Interbody fusion cage |
US5792044A (en) | 1996-03-22 | 1998-08-11 | Danek Medical, Inc. | Devices and methods for percutaneous surgery |
DE19612276A1 (en) | 1996-03-28 | 1997-10-02 | Medicad Engineering Gmbh | Bolt for mending fractures of long bones |
US5782747A (en) | 1996-04-22 | 1998-07-21 | Zimmon Science Corporation | Spring based multi-purpose medical instrument |
US5833628A (en) | 1996-04-24 | 1998-11-10 | Yuan; Hansen | Graduated bone graft harvester |
JPH09291879A (en) | 1996-04-26 | 1997-11-11 | Canyon Corp | Pump dispenser |
US5882345A (en) | 1996-05-22 | 1999-03-16 | Yoon; Inbae | Expandable endoscopic portal |
CN1062346C (en) | 1996-06-03 | 2001-02-21 | 程豹 | Self-sucking grease high effective oil ejector adapting sealed oil tank |
US5681317A (en) | 1996-06-12 | 1997-10-28 | Johnson & Johnson Professional, Inc. | Cement delivery system and method |
DE19624446C1 (en) | 1996-06-19 | 1998-03-26 | Ferton Holding | Surgical instrument for mechanical removal of bone cement, and method for generating shock waves |
US5824084A (en) | 1996-07-03 | 1998-10-20 | The Cleveland Clinic Foundation | Method of preparing a composite bone graft |
US5941851A (en) | 1996-07-12 | 1999-08-24 | C.R. Bard, Inc. | Pulsed lavage handpiece with improved handle |
US5785647A (en) | 1996-07-31 | 1998-07-28 | United States Surgical Corporation | Surgical instruments useful for spinal surgery |
DE19641775A1 (en) | 1996-08-22 | 1998-02-26 | Merck Patent Gmbh | Process for the production of active ingredient-containing bone cements |
US5827217A (en) | 1996-09-04 | 1998-10-27 | Silver; Frederick H. | Process and apparatus for harvesting tissue for processing tissue and process and apparatus for re-injecting processed tissue |
NL1004020C1 (en) | 1996-09-12 | 1998-03-13 | Rademaker B V | Kneading device for doughs and pastes. |
FR2753368B1 (en) | 1996-09-13 | 1999-01-08 | Chauvin Jean Luc | EXPANSIONAL OSTEOSYNTHESIS CAGE |
US5830194A (en) | 1996-09-20 | 1998-11-03 | Azam Anwar | Power syringe |
US5893850A (en) | 1996-11-12 | 1999-04-13 | Cachia; Victor V. | Bone fixation device |
US5876116A (en) | 1996-11-15 | 1999-03-02 | Barker; Donald | Integrated bone cement mixing and dispensing system |
US6033105A (en) | 1996-11-15 | 2000-03-07 | Barker; Donald | Integrated bone cement mixing and dispensing system |
JP3786483B2 (en) | 1996-11-20 | 2006-06-14 | 東レ・ダウコーニング株式会社 | Method and apparatus for quantitative application of highly viscous substances |
US5902839A (en) | 1996-12-02 | 1999-05-11 | Northwestern University | Bone cement and method of preparation |
CN1244815A (en) | 1996-12-13 | 2000-02-16 | 诺瑞安有限公司 | Preparation, storage and administration of cements |
US5868782A (en) | 1996-12-24 | 1999-02-09 | Global Therapeutics, Inc. | Radially expandable axially non-contracting surgical stent |
US6007496A (en) | 1996-12-30 | 1999-12-28 | Brannon; James K. | Syringe assembly for harvesting bone |
US6136038A (en) | 1996-12-30 | 2000-10-24 | Xenon Research, Inc. | Bone connective prosthesis and method of forming same |
US5725341A (en) | 1997-01-08 | 1998-03-10 | Hofmeister; Oskar | Self fusing fastener |
DE19702907A1 (en) | 1997-01-28 | 1998-07-30 | Boehringer Mannheim Gmbh | Method and device for the purification of nucleic acids |
DE19704293A1 (en) | 1997-02-05 | 1998-08-06 | Basf Ag | Denture adhesive |
US6039761A (en) | 1997-02-12 | 2000-03-21 | Li Medical Technologies, Inc. | Intervertebral spacer and tool and method for emplacement thereof |
US20020068771A1 (en) | 1997-02-21 | 2002-06-06 | Dentsply Detrey Gmbh. | Low shrinking polymerizable dental material |
US5884818A (en) | 1997-02-24 | 1999-03-23 | Campbell; Norman | Grease gun |
US20070282443A1 (en) | 1997-03-07 | 2007-12-06 | Disc-O-Tech Medical Technologies Ltd. | Expandable element |
US5842786A (en) * | 1997-03-07 | 1998-12-01 | Solomon; Alan | Method and device for mixing medical compositions |
IL128261A0 (en) | 1999-01-27 | 1999-11-30 | Disc O Tech Medical Tech Ltd | Expandable element |
WO2001054598A1 (en) | 1998-03-06 | 2001-08-02 | Disc-O-Tech Medical Technologies, Ltd. | Expanding bone implants |
ES2302349T3 (en) | 1997-03-07 | 2008-07-01 | Disc-O-Tech Medical Technologies, Ltd. | SYSTEMS FOR THE STABILIZATION, FIXING AND REPAIR OSEA AND VERTEBRAL PERCUTANEAS. |
US5829875A (en) | 1997-04-02 | 1998-11-03 | Simpson Strong-Tie Co., Inc. | Combined barrier and mixer assembly for a cylindrical container |
ATE235196T1 (en) | 1997-04-16 | 2003-04-15 | Sulzer Orthopaedie Ag | FILLING DEVICE FOR BONE CEMENT |
US5800549A (en) | 1997-04-30 | 1998-09-01 | Howmedica Inc. | Method and apparatus for injecting an elastic spinal implant |
DE19718648A1 (en) | 1997-05-02 | 1998-11-05 | Merck Patent Gmbh | Method and device for producing sterile packed bone cement |
US5876457A (en) | 1997-05-20 | 1999-03-02 | George J. Picha | Spinal implant |
US5931347A (en) | 1997-05-23 | 1999-08-03 | Haubrich; Mark A. | Dispenser unit for viscous substances |
US6149651A (en) | 1997-06-02 | 2000-11-21 | Sdgi Holdings, Inc. | Device for supporting weak bony structures |
US5972015A (en) | 1997-08-15 | 1999-10-26 | Kyphon Inc. | Expandable, asymetric structures for deployment in interior body regions |
US6599005B2 (en) | 1997-06-13 | 2003-07-29 | Hosokawa Micron Bv | Intensive mixer |
US5968008A (en) | 1997-08-04 | 1999-10-19 | Grams; Guenter A. | Cannula with parallel channels and sliding sheath |
US6048346A (en) | 1997-08-13 | 2000-04-11 | Kyphon Inc. | Systems and methods for injecting flowable materials into bones |
DE69809158T2 (en) | 1997-08-28 | 2003-03-20 | Ngk Spark Plug Co | Calcium phosphate cement and calcium phosphate cement composition |
US6217566B1 (en) | 1997-10-02 | 2001-04-17 | Target Therapeutics, Inc. | Peripheral vascular delivery catheter |
US6610004B2 (en) | 1997-10-09 | 2003-08-26 | Orqis Medical Corporation | Implantable heart assist system and method of applying same |
US6309420B1 (en) | 1997-10-14 | 2001-10-30 | Parallax Medical, Inc. | Enhanced visibility materials for implantation in hard tissue |
US6033411A (en) | 1997-10-14 | 2000-03-07 | Parallax Medical Inc. | Precision depth guided instruments for use in vertebroplasty |
US5968999A (en) | 1997-10-28 | 1999-10-19 | Charlotte-Mecklenburg Hospital Authority | Bone cement compositions |
US5826753A (en) | 1997-11-04 | 1998-10-27 | Mcneil (Ohio) Corporation | Grease gun locking mechanism |
US6080579A (en) | 1997-11-26 | 2000-06-27 | Charlotte-Mecklenburg Hospital Authority | Method for producing human intervertebral disc cells |
US6348058B1 (en) | 1997-12-12 | 2002-02-19 | Surgical Navigation Technologies, Inc. | Image guided spinal surgery guide, system, and method for use thereof |
US6468279B1 (en) | 1998-01-27 | 2002-10-22 | Kyphon Inc. | Slip-fit handle for hand-held instruments that access interior body regions |
US6533807B2 (en) | 1998-02-05 | 2003-03-18 | Medtronic, Inc. | Radially-expandable stent and delivery system |
US5928239A (en) | 1998-03-16 | 1999-07-27 | University Of Washington | Percutaneous surgical cavitation device and method |
ATE324835T1 (en) | 1998-03-27 | 2006-06-15 | Cook Urological Inc | MINIMAL-INVASIVE DEVICE FOR CATCHING OBJECTS IN HOLLOW ORGANS |
AU3203599A (en) | 1998-04-01 | 1999-10-18 | Parallax Medical, Inc. | Pressure applicator for hard tissue implant placement |
US7572263B2 (en) | 1998-04-01 | 2009-08-11 | Arthrocare Corporation | High pressure applicator |
US6241729B1 (en) | 1998-04-09 | 2001-06-05 | Sdgi Holdings, Inc. | Method and instrumentation for posterior interbody fusion |
CA2327730A1 (en) | 1998-04-10 | 1999-10-21 | Wm Marsh Rice University | Synthesis of poly(propylene fumarate) by acylation of propylene glycol in the presence of a proton scavenger |
US5954671A (en) | 1998-04-20 | 1999-09-21 | O'neill; Michael J. | Bone harvesting method and apparatus |
DE19818210C5 (en) | 1998-04-24 | 2007-02-08 | Ivoclar Vivadent Ag | Radically polymerizable dental material |
US6004325A (en) | 1998-05-11 | 1999-12-21 | Vargas, Iii; Joseph H. | Biomedical cement bonding enhancement tube |
US6447478B1 (en) | 1998-05-15 | 2002-09-10 | Ronald S. Maynard | Thin-film shape memory alloy actuators and processing methods |
US6719773B1 (en) | 1998-06-01 | 2004-04-13 | Kyphon Inc. | Expandable structures for deployment in interior body regions |
US6126689A (en) | 1998-06-15 | 2000-10-03 | Expanding Concepts, L.L.C. | Collapsible and expandable interbody fusion device |
US6041977A (en) | 1998-07-23 | 2000-03-28 | Lisi; Edmund T. | Dispensing system for decorating or filling edible products |
AU5232899A (en) | 1998-07-27 | 2000-02-21 | Focal, Inc. | Universal modular surgical applicator systems |
US6149664A (en) | 1998-08-27 | 2000-11-21 | Micrus Corporation | Shape memory pusher introducer for vasoocclusive devices |
US6113583A (en) | 1998-09-15 | 2000-09-05 | Baxter International Inc. | Vial connecting device for a sliding reconstitution device for a diluent container |
JP2000126214A (en) | 1998-09-16 | 2000-05-09 | Sulzer Orthopedics Ltd | Packing and transferring device of bone cement |
US6086594A (en) | 1998-10-16 | 2000-07-11 | Brown; Byron L. | Cement pressurizing device |
US6261289B1 (en) | 1998-10-26 | 2001-07-17 | Mark Levy | Expandable orthopedic device |
US6554833B2 (en) | 1998-10-26 | 2003-04-29 | Expanding Orthopedics, Inc. | Expandable orthopedic device |
US6206058B1 (en) | 1998-11-09 | 2001-03-27 | The Procter & Gamble Company | Integrated vent and fluid transfer fitment |
US6364865B1 (en) | 1998-11-13 | 2002-04-02 | Elan Pharma International Limited | Drug delivery systems and methods |
US6214012B1 (en) | 1998-11-13 | 2001-04-10 | Harrington Arthritis Research Center | Method and apparatus for delivering material to a desired location |
JP4159202B2 (en) | 1998-12-21 | 2008-10-01 | 日本特殊陶業株式会社 | Calcium phosphate cement kneading apparatus and method for preparing calcium phosphate cement kneaded material |
US6120174A (en) | 1999-01-14 | 2000-09-19 | Bristol-Myers Squibb | Apparatus and method for mixing and dispensing bone cement |
US6116773A (en) | 1999-01-22 | 2000-09-12 | Murray; William M. | Bone cement mixer and method |
CA2360529A1 (en) | 1999-01-28 | 2000-08-03 | Minrad Inc. | Sampling device and method of retrieving a sample |
US6264659B1 (en) | 1999-02-22 | 2001-07-24 | Anthony C. Ross | Method of treating an intervertebral disk |
US6436143B1 (en) | 1999-02-22 | 2002-08-20 | Anthony C. Ross | Method and apparatus for treating intervertebral disks |
SE521945C2 (en) | 1999-02-26 | 2003-12-23 | Biomet Merck Cementing Technol | Mixing device for making bone cement |
DE60005423T2 (en) | 1999-03-03 | 2004-07-22 | KURARAY CO., LTD, Kurashiki | Relining material for dentures |
US6770079B2 (en) | 1999-03-16 | 2004-08-03 | American Osteomedix, Inc. | Apparatus and method for fixation of osteoporotic bone |
US6709465B2 (en) | 1999-03-18 | 2004-03-23 | Fossa Medical, Inc. | Radially expanding ureteral device |
US6214037B1 (en) | 1999-03-18 | 2001-04-10 | Fossa Industries, Llc | Radially expanding stent |
US6402701B1 (en) | 1999-03-23 | 2002-06-11 | Fna Concepts, Llc | Biopsy needle instrument |
US6254268B1 (en) | 1999-07-16 | 2001-07-03 | Depuy Orthopaedics, Inc. | Bone cement mixing apparatus |
EP1211184B1 (en) | 1999-04-20 | 2010-01-20 | JMS Co., Ltd. | Cap for container and adaptor for liquid communication |
US6214016B1 (en) | 1999-04-29 | 2001-04-10 | Medtronic, Inc. | Medical instrument positioning device internal to a catheter or lead and method of use |
US6245101B1 (en) | 1999-05-03 | 2001-06-12 | William J. Drasler | Intravascular hinge stent |
US6221029B1 (en) | 1999-05-13 | 2001-04-24 | Stryker Corporation | Universal biopsy system |
JP4329956B2 (en) | 1999-07-21 | 2009-09-09 | 株式会社バンダイナムコゲームス | Card system and information storage medium |
US6224604B1 (en) | 1999-07-30 | 2001-05-01 | Loubert Suddaby | Expandable orthopedic drill for vertebral interbody fusion techniques |
IL131197A (en) | 1999-08-01 | 2009-12-24 | Assaf Dekel | Apparatus for spinal procedures |
US6479565B1 (en) | 1999-08-16 | 2002-11-12 | Harold R. Stanley | Bioactive ceramic cement |
US6620169B1 (en) | 1999-08-26 | 2003-09-16 | Spineology Group, Llc. | Tools and method for processing and injecting bone graft |
CA2287112C (en) | 1999-09-02 | 2008-02-19 | Kieran Murphy | Method and apparatus for strengthening vertebral bodies |
US6783515B1 (en) | 1999-09-30 | 2004-08-31 | Arthrocare Corporation | High pressure delivery system |
JP2001104324A (en) | 1999-10-06 | 2001-04-17 | Ngk Spark Plug Co Ltd | Medicine extruding auxiliary device, and medicine extruding method using the same |
EP1090609A1 (en) | 1999-10-07 | 2001-04-11 | NGK Spark Plug Company Limited | Device and method for preparing calcium phosphate-based cement |
US6599520B2 (en) | 1999-10-14 | 2003-07-29 | Osteotech, Inc. | Method of inducing new bone growth in porous bone sites |
US6575919B1 (en) | 1999-10-19 | 2003-06-10 | Kyphon Inc. | Hand-held instruments that access interior body regions |
DE29919110U1 (en) | 1999-11-01 | 2000-01-27 | Dunsch Herzberg Renate | Device for introducing bone cement into a bone tube |
US6592624B1 (en) | 1999-11-24 | 2003-07-15 | Depuy Acromed, Inc. | Prosthetic implant element |
US6425885B1 (en) | 1999-12-20 | 2002-07-30 | Ultradent Products, Inc. | Hydraulic syringe |
FR2802830B1 (en) | 1999-12-27 | 2002-06-07 | Coatex Sa | USE OF WATER-SOLUBLE POLYMERS AS AN AQUEOUS SUSPENSION AGENT FOR CALCIUM CARBONATE AQUEOUS SUSPENSIONS AND THEIR USES |
US7842068B2 (en) | 2000-12-07 | 2010-11-30 | Integrated Vascular Systems, Inc. | Apparatus and methods for providing tactile feedback while delivering a closure device |
US7166652B2 (en) | 2000-01-14 | 2007-01-23 | Denfotex Ltd. | Polymerisable resin compositions for use in dentistry |
US6458117B1 (en) | 2000-01-19 | 2002-10-01 | Kevin Daniel Pollins, Sr. | Intraosseous infusion assembly and method for intraosseous infusion |
GB2359762B (en) * | 2000-01-31 | 2003-03-12 | Summit Medical Ltd | Orthopaedic cement mixing device |
US6383188B2 (en) | 2000-02-15 | 2002-05-07 | The Spineology Group Llc | Expandable reamer |
US6558386B1 (en) | 2000-02-16 | 2003-05-06 | Trans1 Inc. | Axial spinal implant and method and apparatus for implanting an axial spinal implant within the vertebrae of the spine |
CN1310026A (en) | 2000-02-24 | 2001-08-29 | 宋治中 | Medical adhesive high molecular material and its preparation |
US6740093B2 (en) | 2000-02-28 | 2004-05-25 | Stephen Hochschuler | Method and apparatus for treating a vertebral body |
ATE318559T1 (en) | 2000-04-05 | 2006-03-15 | Kyphon Inc | DEVICES FOR TREATING BROKEN AND/OR DISEASE BONES |
FR2808208B1 (en) | 2000-04-27 | 2002-06-28 | Optimex 2000 Ltd | CANNULA SET FOR HUMAN BODY INJECTIONS |
US6406175B1 (en) | 2000-05-04 | 2002-06-18 | James F. Marino | Bone cement isovolumic mixing and injection device |
WO2001093787A2 (en) | 2000-06-08 | 2001-12-13 | Cook Incorporated | High pressure injection syringe |
US6488667B1 (en) | 2000-06-15 | 2002-12-03 | Kieran P. J. Murphy | Needle control device |
US6450973B1 (en) | 2000-06-16 | 2002-09-17 | Kieran P. J. Murphy | Biopsy gun |
US6749614B2 (en) | 2000-06-23 | 2004-06-15 | Vertelink Corporation | Formable orthopedic fixation system with cross linking |
WO2002000143A1 (en) | 2000-06-27 | 2002-01-03 | Kyphon Inc. | Systems and methods for injecting flowable materials into bones |
CA2414351C (en) | 2000-06-30 | 2008-12-09 | Augmentation-Technology Gmbh | Device for injecting bone cement |
EP1303236B1 (en) | 2000-07-14 | 2008-12-03 | Kyphon SARL | Systems for treating vertebral bodies |
US20080086133A1 (en) | 2003-05-16 | 2008-04-10 | Spineology | Expandable porous mesh bag device and methods of use for reduction, filling, fixation and supporting of bone |
DE60141653D1 (en) | 2000-07-21 | 2010-05-06 | Spineology Group Llc | A STRONG, POROUS NET BAG DEVICE AND ITS USE IN BONE SURGERY |
CA2419196A1 (en) | 2000-08-11 | 2002-02-21 | Sdgi Holdings, Inc. | Surgical instrumentation and method for treatment of the spine |
US6787584B2 (en) | 2000-08-11 | 2004-09-07 | Pentron Corporation | Dental/medical compositions comprising degradable polymers and methods of manufacture thereof |
AU2001286424A1 (en) | 2000-08-16 | 2002-02-25 | Cook Vascular Incorporated | Doppler probe with shapeable portion |
AU2434501A (en) | 2000-09-07 | 2002-03-22 | Sherwood Serv Ag | Apparatus for and treatment of the intervertebral disc |
KR100889416B1 (en) | 2000-10-25 | 2009-03-20 | 키폰 에스에이알엘 | Systems and methods for reducing fractured bone using a fracture reduction cannula |
EP1333912A2 (en) * | 2000-10-25 | 2003-08-13 | Kyphon Inc. | Systems and methods for mixing and transferring flowable materials |
AU2001213042A1 (en) * | 2000-11-13 | 2002-05-21 | Morinaga And Co. Ltd. | Kneading device and forming device |
DE10057616B4 (en) | 2000-11-21 | 2006-09-14 | Stryker Trauma Gmbh | Method for mixing and applying flowable bone cement and bone cement mixing device |
US6800245B1 (en) | 2000-11-28 | 2004-10-05 | Vita Special Purpose Corporation | Sterile polymerizable systems and kits and methods of their manufacture and use |
JP4305594B2 (en) | 2000-11-28 | 2009-07-29 | 株式会社トクヤマ | Dental bonding kit |
US6655828B2 (en) * | 2000-12-01 | 2003-12-02 | Depuy Orthopaedics, Inc. | Bone cement mixing apparatus having improved mixing blade configuration |
US6702455B2 (en) * | 2000-12-01 | 2004-03-09 | Depuy Orthopaedics, Inc. | Bone cement mixing apparatus having improved gearing arrangement for driving a mixing blade |
US6712853B2 (en) | 2000-12-15 | 2004-03-30 | Spineology, Inc. | Annulus-reinforcing band |
US6439439B1 (en) | 2001-01-12 | 2002-08-27 | Telios Orthopedic Systems, Inc. | Bone cement delivery apparatus and hand-held fluent material dispensing apparatus |
DE60207051D1 (en) | 2001-01-26 | 2005-12-08 | Univ Mississippi Medical Ct Ja | BONE CEMENT |
US6450987B1 (en) | 2001-02-01 | 2002-09-17 | Innercool Therapies, Inc. | Collapsible guidewire lumen |
US6758837B2 (en) | 2001-02-08 | 2004-07-06 | Pharmacia Ab | Liquid delivery device and method of use thereof |
AU2002240386A1 (en) | 2001-02-14 | 2002-08-28 | Acist Medical Systems, Inc. | Catheter fluid control system |
WO2002064194A1 (en) | 2001-02-14 | 2002-08-22 | Acist Medical Systems, Inc. | Fluid injector system |
US7008433B2 (en) | 2001-02-15 | 2006-03-07 | Depuy Acromed, Inc. | Vertebroplasty injection device |
US7544196B2 (en) | 2001-02-20 | 2009-06-09 | Orthovita, Inc. | System and kit for delivery of restorative materials |
US6613018B2 (en) | 2001-02-20 | 2003-09-02 | Vita Licensing, Inc. | System and kit for delivery of restorative materials |
US6375659B1 (en) | 2001-02-20 | 2002-04-23 | Vita Licensing, Inc. | Method for delivery of biocompatible material |
DE10108261B4 (en) | 2001-02-21 | 2006-07-20 | Ivoclar Vivadent Ag | Polymerizable composition with particulate composite based filler |
US20020118595A1 (en) | 2001-02-26 | 2002-08-29 | Miller Scott H. | Enclosed implantable material mixing system |
US7087040B2 (en) | 2001-02-28 | 2006-08-08 | Rex Medical, L.P. | Apparatus for delivering ablation fluid to treat lesions |
US7044933B2 (en) | 2001-03-01 | 2006-05-16 | Scimed Life Systems, Inc. | Fluid injection system for coronary intervention |
MXPA03007940A (en) | 2001-03-13 | 2004-10-15 | Mdc Invest Holdings Inc | Pre-filled safety vial injector. |
US6884264B2 (en) | 2001-03-19 | 2005-04-26 | Cambridge Polymer Group, Inc. | System and methods for reducing interfacial porosity in cements |
US20020134801A1 (en) | 2001-03-26 | 2002-09-26 | Stewart David A. | First use flow-delay membrane for pourable containerized motor oils and other viscous fluids |
US6443334B1 (en) | 2001-04-10 | 2002-09-03 | Pentalpha Hong Kong Limited | Comestible fluid dispenser apparatus and method |
US6402758B1 (en) | 2001-04-16 | 2002-06-11 | John Thomas Tolson | Methods for repairing bone using a high pressure cement injection |
US6632235B2 (en) | 2001-04-19 | 2003-10-14 | Synthes (U.S.A.) | Inflatable device and method for reducing fractures in bone and in treating the spine |
ITVI20010126A1 (en) | 2001-05-30 | 2002-11-30 | Tecres Spa | RADIOPACO BONE CEMENT FOR ORTHOPEDIC USE AND METHOD OF REALIZATION |
US20020188300A1 (en) | 2001-06-06 | 2002-12-12 | Arramon Yves P. | Cannula system for hard tissue implant delivery |
DE10129842C1 (en) | 2001-06-15 | 2003-04-24 | Bam Bundesanstalt Matforschung | Process for the production of a bioactive bone cement and bone cement kit |
US6796987B2 (en) | 2001-07-16 | 2004-09-28 | Stryker Instruments | Delivery device for bone cement |
US6599293B2 (en) | 2001-07-16 | 2003-07-29 | Stryker Instruments | Delivery device for bone cement |
US6547432B2 (en) | 2001-07-16 | 2003-04-15 | Stryker Instruments | Bone cement mixing and delivery device for injection and method thereof |
WO2003007854A1 (en) | 2001-07-20 | 2003-01-30 | The Spineology Group, Llc | Device for inserting fill material particles into body cavities |
CN1835720B (en) | 2001-07-25 | 2011-09-28 | Disc整形外科技术股份有限公司 | Deformable tools and implants |
US6375682B1 (en) | 2001-08-06 | 2002-04-23 | Lewis W. Fleischmann | Collapsible, rotatable and expandable spinal hydraulic prosthetic device |
US6793660B2 (en) | 2001-08-20 | 2004-09-21 | Synthes (U.S.A.) | Threaded syringe for delivery of a bone substitute material |
US20030050644A1 (en) | 2001-09-11 | 2003-03-13 | Boucher Ryan P. | Systems and methods for accessing and treating diseased or fractured bone employing a guide wire |
US6706069B2 (en) | 2001-09-13 | 2004-03-16 | J. Lee Berger | Spinal grooved director with built in balloon |
FR2829691B1 (en) | 2001-09-17 | 2004-07-09 | Sedat | DEVICE FOR BIDIRECTIONAL TRANSFER OF A LIQUID BETWEEN A BOTTLE AND A CARPULE |
US6494344B1 (en) | 2001-09-28 | 2002-12-17 | Joseph A. Kressel, Sr. | Liquid dispensing container |
US7029163B2 (en) | 2002-10-07 | 2006-04-18 | Advanced Biomaterial Systems, Inc. | Apparatus for mixing and dispensing components |
EP1441842A4 (en) | 2001-10-09 | 2006-04-12 | Immedica | Multi-component, product handling and delivering system |
US6984063B2 (en) | 2002-10-07 | 2006-01-10 | Advanced Biomaterial Systems, Inc. | Apparatus for mixing and dispensing components |
JP4125234B2 (en) | 2001-11-01 | 2008-07-30 | スパイン・ウェイブ・インコーポレーテッド | Apparatus and method for pretreatment of endplates between discs |
JP4499327B2 (en) | 2001-12-06 | 2010-07-07 | 松崎 浩巳 | Diameter expansion instrument and surgical instrument set |
US6662969B2 (en) | 2001-12-14 | 2003-12-16 | Zaxis, Inc. | Hydraulically and volumetrically dispensing a target fluid |
US6582439B1 (en) | 2001-12-28 | 2003-06-24 | Yacmur Llc | Vertebroplasty system |
IL147783A0 (en) | 2002-01-23 | 2002-08-14 | Disc O Tech Medical Tech Ltd | Locking mechanism for intramedulliary nails |
US7186364B2 (en) | 2002-01-28 | 2007-03-06 | Depuy Products, Inc. | Composite prosthetic bearing constructed of polyethylene and an ethylene-acrylate copolymer and method for making the same |
US6736835B2 (en) | 2002-03-21 | 2004-05-18 | Depuy Acromed, Inc. | Early intervention spinal treatment methods and devices for use therein |
US6921192B2 (en) * | 2002-03-29 | 2005-07-26 | Depuy Orthopaedics, Inc. | Bone cement mixing apparatus |
SE0201052D0 (en) | 2002-04-04 | 2002-04-04 | Cerbio Tech Ab | Biocompatible cement compositions and method of manufacturing |
JP4130412B2 (en) | 2002-04-11 | 2008-08-06 | ジンテーズ ゲゼルシャフト ミト ベシュレンクテル ハフツング | Device for mixing and / or injecting cement |
SE519349C2 (en) | 2002-04-18 | 2003-02-18 | Cemvac System Ab | Bone cement preparation device, comprises mixing bowl and blades mounted in lid |
WO2003101308A1 (en) | 2002-06-04 | 2003-12-11 | Office Of Technology Licensing Stanford University | Device and method for rapid aspiration and collection of body tissue from within an enclosed body space |
JP4112908B2 (en) * | 2002-06-07 | 2008-07-02 | 株式会社日立プラントテクノロジー | Continuous stirring device and continuous polycondensation method of polycondensation resin |
JP4182692B2 (en) * | 2002-06-20 | 2008-11-19 | 油化電子株式会社 | Syringe type drug capsule |
WO2004000240A1 (en) | 2002-06-20 | 2003-12-31 | Doxa Aktiebolag | A system for a chemically bonded ceramic material, a powdered material and a hydration liquid therefore, the ceramic material, a method for its production and a device |
US6730095B2 (en) | 2002-06-26 | 2004-05-04 | Scimed Life Systems, Inc. | Retrograde plunger delivery system |
ITVI20020140A1 (en) | 2002-06-26 | 2003-12-29 | Tecres Spa | DEVICE FOR THE MANUAL DOSING OF A MEDICAL FLUID, PARTICULARLY BONE CEMENT |
EP1545349A1 (en) | 2002-07-12 | 2005-06-29 | Cook Urological Inc. | Flexible cannula shaft |
WO2005017000A1 (en) | 2003-07-31 | 2005-02-24 | Cambridge Polymer Group | Systems and methods for controlling and forming polymer gels |
US7138442B2 (en) | 2002-08-30 | 2006-11-21 | Biomet, Inc. | Reduced exothermic bone replacement cement |
US7217254B2 (en) | 2002-09-20 | 2007-05-15 | Genzyme Corporation | Multi-pressure biocompatible agent delivery device and method |
US7326203B2 (en) | 2002-09-30 | 2008-02-05 | Depuy Acromed, Inc. | Device for advancing a functional element through tissue |
US7294132B2 (en) | 2002-10-03 | 2007-11-13 | Wright Medical Technology, Inc. | Radially ported needle for delivering bone graft material and method of use |
US7066942B2 (en) | 2002-10-03 | 2006-06-27 | Wright Medical Technology, Inc. | Bendable needle for delivering bone graft material and method of use |
US20040073139A1 (en) | 2002-10-11 | 2004-04-15 | Hirsch Joshua A. | Cannula for extracting and implanting material |
TW569231B (en) | 2002-10-25 | 2004-01-01 | Nanya Technology Corp | A block parallel efuse apparatus blown with serial data input |
US6979352B2 (en) | 2002-11-21 | 2005-12-27 | Depuy Acromed | Methods of performing embolism-free vertebroplasty and devices therefor |
US6970734B2 (en) | 2002-12-02 | 2005-11-29 | Boston Scientific Scimed, Inc. | Flexible marker bands |
DE10258140B4 (en) | 2002-12-04 | 2005-12-22 | Aesculap Ag & Co. Kg | System for filling application containers |
US20040122438A1 (en) | 2002-12-23 | 2004-06-24 | Boston Scientific Corporation | Flex-tight interlocking connection tubing for delivery of bone cements/biomaterials for vertebroplasty |
US7270648B2 (en) | 2002-12-23 | 2007-09-18 | Farhad Kazemzadeh | Drug delivery apparatus |
US20040133124A1 (en) | 2003-01-06 | 2004-07-08 | Cook Incorporated. | Flexible biopsy needle |
US6779566B2 (en) | 2003-01-14 | 2004-08-24 | Access Business Group International Llc | Connector device for sealing and dispensing freeze-dried preparations |
US7678333B2 (en) | 2003-01-22 | 2010-03-16 | Duoject Medical Systems Inc. | Fluid transfer assembly for pharmaceutical delivery system and method for using same |
JP2004236729A (en) | 2003-02-04 | 2004-08-26 | Kobayashi Pharmaceut Co Ltd | Bone cement composition |
US6875219B2 (en) | 2003-02-14 | 2005-04-05 | Yves P. Arramon | Bone access system |
AU2004212942A1 (en) | 2003-02-14 | 2004-09-02 | Depuy Spine, Inc. | In-situ formed intervertebral fusion device |
US20040167437A1 (en) | 2003-02-26 | 2004-08-26 | Sharrow James S. | Articulating intracorporal medical device |
US7393493B2 (en) | 2003-02-27 | 2008-07-01 | A Enterprises, Inc. | Crosslinkable polymeric materials and their applications |
EP1614403B2 (en) | 2003-03-14 | 2014-06-18 | Depuy Spine, Inc. | Hydraulic device for the injection of bone cement in percutaneous vertebroplasty |
US8066713B2 (en) | 2003-03-31 | 2011-11-29 | Depuy Spine, Inc. | Remotely-activated vertebroplasty injection device |
US20040220672A1 (en) | 2003-05-03 | 2004-11-04 | Shadduck John H. | Orthopedic implants, methods of use and methods of fabrication |
US20040267272A1 (en) | 2003-05-12 | 2004-12-30 | Henniges Bruce D | Bone cement mixing and delivery system |
DE10321350B4 (en) * | 2003-05-13 | 2005-04-21 | Lurgi Ag | mixing device |
US20040236313A1 (en) | 2003-05-21 | 2004-11-25 | Klein Jeffrey A. | Infiltration cannula |
US20060241606A1 (en) | 2003-06-12 | 2006-10-26 | Disc-O-Tech, Ltd. | Plate device |
US8415407B2 (en) | 2004-03-21 | 2013-04-09 | Depuy Spine, Inc. | Methods, materials, and apparatus for treating bone and other tissue |
US20070032567A1 (en) | 2003-06-17 | 2007-02-08 | Disc-O-Tech Medical | Bone Cement And Methods Of Use Thereof |
US7112205B2 (en) | 2003-06-17 | 2006-09-26 | Boston Scientific Scimed, Inc. | Apparatus and methods for delivering compounds into vertebrae for vertebroplasty |
WO2006011152A2 (en) | 2004-06-17 | 2006-02-02 | Disc-O-Tech Medical Technologies, Ltd. | Methods for treating bone and other tissue |
US7179232B2 (en) | 2003-06-27 | 2007-02-20 | Depuy Acromed, Inc. | Controlled orifice sampling needle |
US7261717B2 (en) | 2003-09-11 | 2007-08-28 | Skeletal Kinetics Llc | Methods and devices for delivering orthopedic cements to a target bone site |
US7261718B2 (en) | 2003-09-11 | 2007-08-28 | Skeletal Kinetics Llc | Use of vibration with polymeric bone cements |
US8579908B2 (en) | 2003-09-26 | 2013-11-12 | DePuy Synthes Products, LLC. | Device for delivering viscous material |
US7909833B2 (en) | 2003-09-29 | 2011-03-22 | Depuy Acromed, Inc. | Vertebroplasty device having a flexible plunger |
EP1680034A2 (en) | 2003-10-07 | 2006-07-19 | Disc-O-Tech Medical Technologies, Ltd. | Soft tissue to bone fixation |
DE10347930A1 (en) * | 2003-10-15 | 2005-05-12 | Bayer Materialscience Ag | stirrer |
DE10353919A1 (en) | 2003-11-18 | 2005-07-07 | Somatex Medical Technologies Gmbh | Injection pump for applying highly viscous media at high pressures comprises a rigid piston rod with a handle and an adjoined flexible piston rod which extends as far as the distal end of the pump body |
US20050113762A1 (en) | 2003-11-24 | 2005-05-26 | Kay John F. | Minimally invasive high viscosity material delivery system |
CA2550476A1 (en) | 2003-12-18 | 2005-09-15 | Halkey-Roberts Corporation | Needleless access vial |
US20050154081A1 (en) | 2004-01-09 | 2005-07-14 | Bisco, Inc. | Opacity and color change polymerizable dental materials |
US8235256B2 (en) | 2004-02-12 | 2012-08-07 | Kyphon Sarl | Manual pump mechanism and delivery system |
US7641664B2 (en) | 2004-02-12 | 2010-01-05 | Warsaw Orthopedic, Inc. | Surgical instrumentation and method for treatment of a spinal structure |
GB2411849B (en) | 2004-03-08 | 2007-08-29 | Summit Medical Ltd | Apparatus for mixing and discharging bone cement |
US8945223B2 (en) | 2004-03-12 | 2015-02-03 | Warsaw Orthopedic, Inc. | In-situ formable nucleus pulposus implant with water absorption and swelling capability |
US20050209695A1 (en) | 2004-03-15 | 2005-09-22 | De Vries Jan A | Vertebroplasty method |
US20050216025A1 (en) | 2004-03-22 | 2005-09-29 | Cana Lab Corporation | Device for forming a hardened cement in a bone cavity |
US6954949B1 (en) | 2004-04-19 | 2005-10-18 | Wonderland Nurserygoods Co., Ltd. | Playpen with double columns at each corner |
FR2870129A1 (en) | 2004-05-14 | 2005-11-18 | Ceravic Sas Soc Par Actions Si | POLYMERIC CEMENT FOR PERCUTANEOUS VERTEBROPLASTY |
AU2004319780A1 (en) | 2004-05-19 | 2005-11-24 | Sintea Biotech S.P.A | Intravertebral widening device, injection device, and kit and method for kyphoplasty |
US7441652B2 (en) | 2004-05-20 | 2008-10-28 | Med Institute, Inc. | Mixing system |
US7708751B2 (en) | 2004-05-21 | 2010-05-04 | Ethicon Endo-Surgery, Inc. | MRI biopsy device |
WO2006002430A2 (en) | 2004-06-16 | 2006-01-05 | Sdgi Holdings, Inc. | Surgical instrumentation for the repair of vertebral bodies |
US8038682B2 (en) | 2004-08-17 | 2011-10-18 | Boston Scientific Scimed, Inc. | Apparatus and methods for delivering compounds into vertebrae for vertebroplasty |
US20080319445A9 (en) | 2004-08-17 | 2008-12-25 | Scimed Life Systems, Inc. | Apparatus and methods for delivering compounds into vertebrae for vertebroplasty |
US7559932B2 (en) | 2004-12-06 | 2009-07-14 | Dfine, Inc. | Bone treatment systems and methods |
US7678116B2 (en) | 2004-12-06 | 2010-03-16 | Dfine, Inc. | Bone treatment systems and methods |
US20060122614A1 (en) | 2004-12-06 | 2006-06-08 | Csaba Truckai | Bone treatment systems and methods |
US7717918B2 (en) | 2004-12-06 | 2010-05-18 | Dfine, Inc. | Bone treatment systems and methods |
US8070753B2 (en) | 2004-12-06 | 2011-12-06 | Dfine, Inc. | Bone treatment systems and methods |
ES2541484T3 (en) | 2004-12-06 | 2015-07-21 | Dfine Inc. | Bone treatment systems and procedures |
US7722620B2 (en) | 2004-12-06 | 2010-05-25 | Dfine, Inc. | Bone treatment systems and methods |
EA011347B1 (en) | 2004-12-16 | 2009-02-27 | Чжуншань Ботай Фармасьютик Инструментс Ко., Лтд. | A drug mixing and delivery device |
US20060164913A1 (en) * | 2005-01-21 | 2006-07-27 | Arthrocare Corporation | Multi-chamber integrated mixing and delivery system |
JP2008531109A (en) * | 2005-02-22 | 2008-08-14 | ディスク−オー−テック メディカル テクノロジーズ, リミテッド | Methods, materials, and devices for treating bone and other tissues |
CA2600387C (en) | 2005-03-07 | 2013-12-10 | Hector O. Pacheco | System and methods for improved access to vertebral bodies for kyphoplasty, vertebroplasty, vertebral body biopsy or screw placement |
US7503469B2 (en) | 2005-03-09 | 2009-03-17 | Rexam Closure Systems Inc. | Integrally molded dispensing valve and method of manufacture |
IL174347A0 (en) | 2005-07-31 | 2006-08-20 | Disc O Tech Medical Tech Ltd | Bone cement and methods of use thereof |
US9381024B2 (en) | 2005-07-31 | 2016-07-05 | DePuy Synthes Products, Inc. | Marked tools |
US9918767B2 (en) | 2005-08-01 | 2018-03-20 | DePuy Synthes Products, Inc. | Temperature control system |
US7116121B1 (en) | 2005-10-27 | 2006-10-03 | Agilent Technologies, Inc. | Probe assembly with controlled impedance spring pin or resistor tip spring pin contacts |
US7799035B2 (en) | 2005-11-18 | 2010-09-21 | Carefusion 2200, Inc. | Device, system and method for delivering a curable material into bone |
US7713273B2 (en) | 2005-11-18 | 2010-05-11 | Carefusion 2200, Inc. | Device, system and method for delivering a curable material into bone |
US7922690B2 (en) | 2006-02-22 | 2011-04-12 | Michael Plishka | Curable material delivery device |
US7892207B2 (en) | 2006-04-27 | 2011-02-22 | Warsaw Orthopedic, Inc. | Dilating stylet and cannula |
WO2008001385A2 (en) | 2006-06-29 | 2008-01-03 | Depuy Spine, Inc. | Integrated bone biopsy and therapy apparatus |
SE530232C2 (en) | 2006-08-11 | 2008-04-08 | Biomet Cementing Technologies | Liquid container for bone cement mixers |
SE530233C2 (en) | 2006-08-11 | 2008-04-08 | Biomet Cementing Technologies | Liquid container for bone cement mixers |
JP2008055367A (en) * | 2006-09-01 | 2008-03-13 | Asada Tekko Kk | Rotary roll type dispersion machine |
CN101516412B (en) | 2006-09-14 | 2014-02-12 | 德普伊斯派尔公司 | Bone cement and use method thereof |
AU2007311451A1 (en) | 2006-10-19 | 2008-04-24 | Depuy Spine, Inc. | Fluid delivery system |
CN102083702B (en) | 2008-04-24 | 2013-04-03 | 凸版印刷株式会社 | Packaging container and package using the same |
DE102009002630B4 (en) * | 2009-04-24 | 2019-12-24 | Robert Bosch Gmbh | Device for dosing powdery substances |
US8226126B2 (en) | 2009-08-24 | 2012-07-24 | Jpro Dairy International, Inc. | Bottle mixing assembly |
-
2006
- 2006-07-06 US US11/428,908 patent/US8360629B2/en active Active
-
2007
- 2007-07-04 CN CN200780025680.0A patent/CN101528332B/en active Active
- 2007-07-04 KR KR1020097002317A patent/KR20090026356A/en active IP Right Grant
- 2007-07-04 CA CA2656779A patent/CA2656779C/en not_active Expired - Fee Related
- 2007-07-04 JP JP2009517607A patent/JP5627887B2/en active Active
- 2007-07-04 WO PCT/IL2007/000833 patent/WO2008004229A2/en active Application Filing
- 2007-07-04 EP EP07766863.0A patent/EP2037789B1/en active Active
- 2007-07-04 ES ES12181745.6T patent/ES2562619T3/en active Active
- 2007-07-04 EP EP20090151379 patent/EP2047900B1/en active Active
- 2007-07-04 EP EP12181745.6A patent/EP2527031B1/en active Active
- 2007-07-04 EP EP13174874.1A patent/EP2662132B1/en active Active
- 2007-07-04 ES ES07766863.0T patent/ES2525002T3/en active Active
- 2007-07-04 ES ES13174874.1T patent/ES2556882T3/en active Active
- 2007-07-04 AU AU2007270684A patent/AU2007270684B2/en active Active
- 2007-07-04 CA CA 2763752 patent/CA2763752C/en not_active Expired - Fee Related
- 2007-07-04 CN CN201510099411.5A patent/CN104689738B/en active Active
- 2007-07-04 ES ES09151379.6T patent/ES2530195T3/en active Active
-
2012
- 2012-06-05 AU AU2012203300A patent/AU2012203300B2/en active Active
- 2012-08-10 US US13/571,802 patent/US9259696B2/en active Active
-
2016
- 2016-02-11 US US15/041,572 patent/US10631906B2/en active Active
Patent Citations (100)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US843587A (en) * | 1906-01-29 | 1907-02-12 | Henry Hannon De Pew | Surgical instrument. |
US1612996A (en) * | 1926-02-23 | 1927-01-04 | Waagbo Herman | Cream-testing device |
US1894274A (en) * | 1930-08-22 | 1933-01-17 | Raynaldo P Jacques | Lubricating apparatus |
US2067458A (en) * | 1934-07-13 | 1937-01-12 | Nat Rubber Machinery Co | Rubber mixing mill |
US2394488A (en) * | 1943-05-07 | 1946-02-05 | Lincoln Eng Co | Lubricating apparatus |
US2435647A (en) * | 1945-02-21 | 1948-02-10 | Martin O Engseth | Grease gun |
US2497762A (en) * | 1945-10-04 | 1950-02-14 | Ernest W Davis | Lubrication gun |
US2874877A (en) * | 1956-09-11 | 1959-02-24 | Alvin C Spencer | Dispensing device and container therefor |
US3075746A (en) * | 1958-07-10 | 1963-01-29 | Baker Perkins Inc | Mixer for explosive materials |
US2970773A (en) * | 1959-10-19 | 1961-02-07 | Minnesota Mining & Mfg | Fluid mixing and applying apparatus and method |
US3426364A (en) * | 1966-08-25 | 1969-02-11 | Colorado State Univ Research F | Prosthetic appliance for replacing one or more natural vertebrae |
US3867728A (en) * | 1971-12-30 | 1975-02-25 | Cutter Lab | Prosthesis for spinal repair |
US3789727A (en) * | 1972-06-05 | 1974-02-05 | Eaton Corp | Fastener |
US3931914A (en) * | 1973-07-10 | 1976-01-13 | Max Kabushiki Kaisha | Powder ejector |
US4189065A (en) * | 1976-02-04 | 1980-02-19 | Espe Fabrik Pharmazeutischer Praeparate Gmbh | Metering dispenser for high-viscosity compositions |
US4185072A (en) * | 1977-02-17 | 1980-01-22 | Diemolding Corporation | Orthopedic cement mixer |
US4373217A (en) * | 1979-02-16 | 1983-02-15 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Implantation materials and a process for the production thereof |
US4250887A (en) * | 1979-04-18 | 1981-02-17 | Dardik Surgical Associates, P.A. | Remote manual injecting apparatus |
US4312343A (en) * | 1979-07-30 | 1982-01-26 | Leveen Harry H | Syringe |
US5704895A (en) * | 1979-12-28 | 1998-01-06 | American Medical Systems, Inc. | Implantable penile prosthetic cylinder with inclusive fluid reservoir |
US4313434A (en) * | 1980-10-17 | 1982-02-02 | David Segal | Fracture fixation |
US4309777A (en) * | 1980-11-13 | 1982-01-12 | Patil Arun A | Artificial intervertebral disc |
US4562598A (en) * | 1981-04-01 | 1986-01-07 | Mecron Medizinische Produkte Gmbh | Joint prosthesis |
US4494535A (en) * | 1981-06-24 | 1985-01-22 | Haig Armen C | Hip nail |
US5601557A (en) * | 1982-05-20 | 1997-02-11 | Hayhurst; John O. | Anchoring and manipulating tissue |
US4500658A (en) * | 1983-06-06 | 1985-02-19 | Austenal International, Inc. | Radiopaque acrylic resin |
US4722948A (en) * | 1984-03-16 | 1988-02-02 | Dynatech Corporation | Bone replacement and repair putty material from unsaturated polyester resin and vinyl pyrrolidone |
US4717383A (en) * | 1984-07-31 | 1988-01-05 | N.J. Phillips Pty. Limited | Injector |
US4642099A (en) * | 1984-07-31 | 1987-02-10 | N.J. Phillips Pty. Limited | Injector |
US4636217A (en) * | 1985-04-23 | 1987-01-13 | Regents Of The University Of Minnesota | Anterior spinal implant |
US4718910A (en) * | 1985-07-16 | 1988-01-12 | Klaus Draenert | Bone cement and process for preparing the same |
US4892550A (en) * | 1985-12-30 | 1990-01-09 | Huebsch Donald L | Endoprosthesis device and method |
US4804023A (en) * | 1986-05-23 | 1989-02-14 | Avdel Limited, British Company | Hydraulic fluid replenishment device |
US4892231A (en) * | 1986-07-16 | 1990-01-09 | Metal Box P.L.C. | Pump chamber dispenser |
US4902649A (en) * | 1986-09-10 | 1990-02-20 | Showa Denko Kabushiki Kaisha | Hard tissue substitute composition |
US4983164A (en) * | 1987-04-14 | 1991-01-08 | Astra Meditec Ab | Automatic two-chamber injector |
US4904260A (en) * | 1987-08-20 | 1990-02-27 | Cedar Surgical, Inc. | Prosthetic disc containing therapeutic material |
US5865802A (en) * | 1988-07-22 | 1999-02-02 | Yoon; Inbae | Expandable multifunctional instruments for creating spaces at obstructed sites endoscopically |
US4995868A (en) * | 1988-10-12 | 1991-02-26 | Bard Limited | Catheter |
US5387191A (en) * | 1989-02-06 | 1995-02-07 | Board Of Regents Of The Univ. Of Okla. | Flushing needle |
US5380772A (en) * | 1989-12-11 | 1995-01-10 | G-C Toshi Kogyo Corporation | Modelling liquid for dental porcelain |
US5276070A (en) * | 1990-01-25 | 1994-01-04 | Pfizer Hospital Products Group, Inc. | Bone cement |
US5707390A (en) * | 1990-03-02 | 1998-01-13 | General Surgical Innovations, Inc. | Arthroscopic retractors |
US5078919A (en) * | 1990-03-20 | 1992-01-07 | The United States Of America As Represented By The United States Department Of Energy | Composition containing aerogel substrate loaded with tritium |
US4994065A (en) * | 1990-05-18 | 1991-02-19 | Zimmer, Inc. | Apparatus for dispensing low viscosity semi-fluid material under pressure |
US5181918A (en) * | 1990-08-10 | 1993-01-26 | Thera Patent Gmbh & Co. Kg Gesellschaft Fuer Industrielle Schutzrechte | Granules syringe |
US5188259A (en) * | 1991-02-01 | 1993-02-23 | Petit Jeffrey D | Caulking gun with belt worn cartridge |
US5390683A (en) * | 1991-02-22 | 1995-02-21 | Pisharodi; Madhavan | Spinal implantation methods utilizing a middle expandable implant |
US5480403A (en) * | 1991-03-22 | 1996-01-02 | United States Surgical Corporation | Suture anchoring device and method |
US5720753A (en) * | 1991-03-22 | 1998-02-24 | United States Surgical Corporation | Orthopedic fastener |
US5494349A (en) * | 1991-12-06 | 1996-02-27 | Summit Medical Ltd. | Bone cement mixing device |
US5385566A (en) * | 1992-02-20 | 1995-01-31 | Ullmark; Goesta | Device and a method for use in transplantation of bone tissue material |
US5277339A (en) * | 1992-03-26 | 1994-01-11 | Alemite Corporation | Dual mode pistol-grip grease gun |
US5279555A (en) * | 1992-08-24 | 1994-01-18 | Merck & Co., Inc. | Device for injecting implants |
US5275214A (en) * | 1992-10-28 | 1994-01-04 | Rehberger Kevin M | Apparatus for unloading pressurized fluid |
US5385081A (en) * | 1993-09-09 | 1995-01-31 | Arde Incorporated | Fluid storage tank employing a shear seal |
US5482187A (en) * | 1993-09-13 | 1996-01-09 | Hygienix, Inc. | Dispenser for viscous substances |
US5480400A (en) * | 1993-10-01 | 1996-01-02 | Berger; J. Lee | Method and device for internal fixation of bone fractures |
US5492247A (en) * | 1994-06-02 | 1996-02-20 | Shu; Aling | Automatic soap dispenser |
US5591197A (en) * | 1995-03-14 | 1997-01-07 | Advanced Cardiovascular Systems, Inc. | Expandable stent forming projecting barbs and method for deploying |
US5603701A (en) * | 1995-03-27 | 1997-02-18 | Ultradent Products, Inc. | Syringe apparatus with threaded plunger for delivering tooth composites and other solid yet pliable materials |
US6190381B1 (en) * | 1995-06-07 | 2001-02-20 | Arthrocare Corporation | Methods for tissue resection, ablation and aspiration |
US6168597B1 (en) * | 1996-02-28 | 2001-01-02 | Lutz Biedermann | Bone screw |
US6183441B1 (en) * | 1996-12-18 | 2001-02-06 | Science Incorporated | Variable rate infusion apparatus with indicator and adjustable rate control |
US5718707A (en) * | 1997-01-22 | 1998-02-17 | Mikhail; W. E. Michael | Method and apparatus for positioning and compacting bone graft |
US6187015B1 (en) * | 1997-05-02 | 2001-02-13 | Micro Therapeutics, Inc. | Expandable stent apparatus and method |
US6017349A (en) * | 1997-06-05 | 2000-01-25 | Sulzer Orthopaedie, Ag | Transport and processing apparatus for a two-component material |
US6176607B1 (en) * | 1997-07-29 | 2001-01-23 | Stryker Technologies Corporation | Apparatus for dispensing a liquid component of a two-component bone cement and for storing, mixing, and dispensing the cement |
US6019776A (en) * | 1997-10-14 | 2000-02-01 | Parallax Medical, Inc. | Precision depth guided instruments for use in vertebroplasty |
US6348518B1 (en) * | 1997-12-10 | 2002-02-19 | R. Eric Montgomery | Compositions for making an artificial prosthesis |
US6174935B1 (en) * | 1997-12-24 | 2001-01-16 | Gc Corporation | Dental adhesive kit |
US6020396A (en) * | 1998-03-13 | 2000-02-01 | The Penn State Research Foundation | Bone cement compositions |
US6019789A (en) * | 1998-04-01 | 2000-02-01 | Quanam Medical Corporation | Expandable unit cell and intraluminal stent |
US6019765A (en) * | 1998-05-06 | 2000-02-01 | Johnson & Johnson Professional, Inc. | Morsellized bone allograft applicator device |
US20040010263A1 (en) * | 1998-06-01 | 2004-01-15 | Kyphon Inc. | Expandable preformed structures for deployment in interior body regions |
US6183516B1 (en) * | 1998-10-08 | 2001-02-06 | Sulzer Orthopedics Inc. | Method for improved bonding of prosthetic devices to bone |
US20030032929A1 (en) * | 1998-12-09 | 2003-02-13 | Mcguckin James F. | Hollow curved superelastic medical needle and method |
US20030036763A1 (en) * | 1999-03-16 | 2003-02-20 | Mohit Bhatnagar | Apparatus and method for fixation of osteoporotic bone |
US6348055B1 (en) * | 1999-03-24 | 2002-02-19 | Parallax Medical, Inc. | Non-compliant system for delivery of implant material |
US6689823B1 (en) * | 1999-03-31 | 2004-02-10 | The Brigham And Women's Hospital, Inc. | Nanocomposite surgical materials and method of producing them |
US6350271B1 (en) * | 1999-05-17 | 2002-02-26 | Micrus Corporation | Clot retrieval device |
US6676664B1 (en) * | 1999-08-05 | 2004-01-13 | Grupo Grifols, S.A. | Device for metering hardenable mass for vertebroplastia and other similar bone treatments |
US20030031698A1 (en) * | 2000-01-31 | 2003-02-13 | Roeder Ryan K. | Composite biomaterial including anisometric calcium phosphate reinforcement particles and related methods |
US20020010471A1 (en) * | 2000-02-04 | 2002-01-24 | Wironen John F. | Methods for injecting materials into bone |
US6502608B1 (en) * | 2000-02-14 | 2003-01-07 | Telios Orthopedic Systems, Inc. | Delivery apparatus, nozzle, and removable tip assembly |
US20020013553A1 (en) * | 2000-05-25 | 2002-01-31 | Pajunk Gmbh | Apparatus for the application of bone cement and a cannula for such an apparatus |
US20020010472A1 (en) * | 2000-06-30 | 2002-01-24 | Kuslich Stephen D. | Tool to direct bone replacement material |
US20020008122A1 (en) * | 2000-07-06 | 2002-01-24 | Stefan Ritsche | Discharge apparatus for media |
US6852439B2 (en) * | 2001-05-15 | 2005-02-08 | Hydrogenics Corporation | Apparatus for and method of forming seals in fuel cells and fuel cell stacks |
US20030018339A1 (en) * | 2001-07-19 | 2003-01-23 | Higueras Antonio Perez | Applicator device for controllably injecting a surgical cement into bones |
US20030040718A1 (en) * | 2001-08-21 | 2003-02-27 | Richard Kust | Apparatus for delivering a viscous liquid to a surgical site |
US20050014273A1 (en) * | 2001-08-29 | 2005-01-20 | Dahm Michael Werner | Method and device for preparing a sample of biological origin in order to determine at least one constituent contained therein |
US6994465B2 (en) * | 2002-03-14 | 2006-02-07 | Stryker Instruments | Mixing assembly for mixing bone cement |
US20040029996A1 (en) * | 2002-05-29 | 2004-02-12 | Heraeus Kulzer Gmbh & Co. Kg | Bone cement mixture and x-ray contrast medium as well as method for their preparation |
US20060041033A1 (en) * | 2003-02-13 | 2006-02-23 | Adrian Bisig | Injectable bone-replacement mixture |
US20050015148A1 (en) * | 2003-07-18 | 2005-01-20 | Jansen Lex P. | Biocompatible wires and methods of using same to fill bone void |
US20050025622A1 (en) * | 2003-07-28 | 2005-02-03 | Pratt & Whitney Canada Corp. | Blade inlet cooling flow deflector apparatus and method |
US20060035997A1 (en) * | 2004-08-10 | 2006-02-16 | Orlowski Jan A | Curable acrylate polymer compositions featuring improved flexural characteristics |
US20070019802A1 (en) * | 2005-06-30 | 2007-01-25 | Symbol Technologies, Inc. | Audio data stream synchronization |
US20120307586A1 (en) * | 2005-11-22 | 2012-12-06 | Depuy Spine, Inc. | Mixing apparatus |
Cited By (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE47427E1 (en) | 1999-01-27 | 2019-06-11 | Medtronic Holding Company Sárl | Expandable intervertebral spacer |
US9186194B2 (en) | 2003-03-14 | 2015-11-17 | DePuy Synthes Products, Inc. | Hydraulic device for the injection of bone cement in percutaneous vertebroplasty |
US10799278B2 (en) | 2003-03-14 | 2020-10-13 | DePuy Synthes Products, Inc. | Hydraulic device for the injection of bone cement in percutaneous vertebroplasty |
US8992541B2 (en) | 2003-03-14 | 2015-03-31 | DePuy Synthes Products, LLC | Hydraulic device for the injection of bone cement in percutaneous vertebroplasty |
US8066713B2 (en) | 2003-03-31 | 2011-11-29 | Depuy Spine, Inc. | Remotely-activated vertebroplasty injection device |
US9839460B2 (en) | 2003-03-31 | 2017-12-12 | DePuy Synthes Products, Inc. | Remotely-activated vertebroplasty injection device |
US8333773B2 (en) | 2003-03-31 | 2012-12-18 | Depuy Spine, Inc. | Remotely-activated vertebroplasty injection device |
US10485597B2 (en) | 2003-03-31 | 2019-11-26 | DePuy Synthes Products, Inc. | Remotely-activated vertebroplasty injection device |
US8540722B2 (en) | 2003-06-17 | 2013-09-24 | DePuy Synthes Products, LLC | Methods, materials and apparatus for treating bone and other tissue |
US9504508B2 (en) | 2003-06-17 | 2016-11-29 | DePuy Synthes Products, Inc. | Methods, materials and apparatus for treating bone and other tissue |
US10039585B2 (en) | 2003-06-17 | 2018-08-07 | DePuy Synthes Products, Inc. | Methods, materials and apparatus for treating bone and other tissue |
US8956368B2 (en) | 2003-06-17 | 2015-02-17 | DePuy Synthes Products, LLC | Methods, materials and apparatus for treating bone and other tissue |
US8361078B2 (en) | 2003-06-17 | 2013-01-29 | Depuy Spine, Inc. | Methods, materials and apparatus for treating bone and other tissue |
US10111697B2 (en) | 2003-09-26 | 2018-10-30 | DePuy Synthes Products, Inc. | Device for delivering viscous material |
US8579908B2 (en) | 2003-09-26 | 2013-11-12 | DePuy Synthes Products, LLC. | Device for delivering viscous material |
US8809418B2 (en) | 2004-03-21 | 2014-08-19 | DePuy Synthes Products, LLC | Methods, materials and apparatus for treating bone and other tissue |
US9750840B2 (en) | 2004-03-21 | 2017-09-05 | DePuy Synthes Products, Inc. | Methods, materials and apparatus for treating bone and other tissue |
US8415407B2 (en) | 2004-03-21 | 2013-04-09 | Depuy Spine, Inc. | Methods, materials, and apparatus for treating bone and other tissue |
WO2007015202A2 (en) | 2005-07-31 | 2007-02-08 | Depuy Spine, Inc., A Johnson & Johnson Company | Bone cement and methods of use thereof |
US9381024B2 (en) | 2005-07-31 | 2016-07-05 | DePuy Synthes Products, Inc. | Marked tools |
US9918767B2 (en) | 2005-08-01 | 2018-03-20 | DePuy Synthes Products, Inc. | Temperature control system |
US20090114616A1 (en) * | 2005-09-05 | 2009-05-07 | Gerard Andrew White | Blender with Co-Operating Jug and Blades |
US8834015B2 (en) * | 2005-09-05 | 2014-09-16 | Breville Pty Limited | Blender with co-operating jug and blades |
US9259696B2 (en) * | 2005-11-22 | 2016-02-16 | DePuy Synthes Products, Inc. | Mixing apparatus having central and planetary mixing elements |
US20120307586A1 (en) * | 2005-11-22 | 2012-12-06 | Depuy Spine, Inc. | Mixing apparatus |
US8360629B2 (en) * | 2005-11-22 | 2013-01-29 | Depuy Spine, Inc. | Mixing apparatus having central and planetary mixing elements |
US20160235459A1 (en) * | 2005-11-22 | 2016-08-18 | DePuy Synthes Products, Inc. | Mixing apparatus |
US10631906B2 (en) * | 2005-11-22 | 2020-04-28 | DePuy Synthes Products, Inc. | Apparatus for transferring a viscous material |
US10272174B2 (en) | 2006-09-14 | 2019-04-30 | DePuy Synthes Products, Inc. | Bone cement and methods of use thereof |
US9642932B2 (en) | 2006-09-14 | 2017-05-09 | DePuy Synthes Products, Inc. | Bone cement and methods of use thereof |
US10494158B2 (en) | 2006-10-19 | 2019-12-03 | DePuy Synthes Products, Inc. | Fluid delivery system |
US8950929B2 (en) | 2006-10-19 | 2015-02-10 | DePuy Synthes Products, LLC | Fluid delivery system |
US9788870B2 (en) | 2008-01-14 | 2017-10-17 | Conventus Orthopaedics, Inc. | Apparatus and methods for fracture repair |
US9517093B2 (en) | 2008-01-14 | 2016-12-13 | Conventus Orthopaedics, Inc. | Apparatus and methods for fracture repair |
US11399878B2 (en) | 2008-01-14 | 2022-08-02 | Conventus Orthopaedics, Inc. | Apparatus and methods for fracture repair |
US8287538B2 (en) | 2008-01-14 | 2012-10-16 | Conventus Orthopaedics, Inc. | Apparatus and methods for fracture repair |
US10603087B2 (en) | 2008-01-14 | 2020-03-31 | Conventus Orthopaedics, Inc. | Apparatus and methods for fracture repair |
USRE48870E1 (en) | 2008-10-30 | 2022-01-04 | DePuy Synthes Products, Inc. | Systems and methods for delivering bone cement to a bone anchor |
US20100114174A1 (en) * | 2008-10-30 | 2010-05-06 | Bryan Jones | Systems and Methods for Delivering Bone Cement to a Bone Anchor |
EP2745789A1 (en) | 2008-10-30 | 2014-06-25 | Depuy Spine Inc. | Systems for delivering bone cement to a bone anchor |
US9265548B2 (en) | 2008-10-30 | 2016-02-23 | DePuy Synthes Products, Inc. | Systems and methods for delivering bone cement to a bone anchor |
USRE47871E1 (en) | 2008-10-30 | 2020-02-25 | DePuy Synthes Products, Inc. | Systems and methods for delivering bone cement to a bone anchor |
WO2011086291A1 (en) * | 2009-12-22 | 2011-07-21 | Seb S.A. | Kitchen appliance, in particular for preparing flour-based dough |
FR2954181A1 (en) * | 2009-12-22 | 2011-06-24 | Michel Marcel Andre Loiselet | CULINARY PREPARATION APPARATUS, IN PARTICULAR FOR THE PREPARATION OF FLOUR-BASED PASTA |
WO2011082015A3 (en) * | 2009-12-31 | 2011-08-25 | Cook Incorporated | Vertebroplasty cement mixer injector device |
US8348494B2 (en) | 2009-12-31 | 2013-01-08 | Cook Medical Technologies Llc | Vertebroplasty cement mixer injector device |
US9730739B2 (en) | 2010-01-15 | 2017-08-15 | Conventus Orthopaedics, Inc. | Rotary-rigid orthopaedic rod |
US9848889B2 (en) | 2010-01-20 | 2017-12-26 | Conventus Orthopaedics, Inc. | Apparatus and methods for bone access and cavity preparation |
US8961518B2 (en) | 2010-01-20 | 2015-02-24 | Conventus Orthopaedics, Inc. | Apparatus and methods for bone access and cavity preparation |
US8906022B2 (en) | 2010-03-08 | 2014-12-09 | Conventus Orthopaedics, Inc. | Apparatus and methods for securing a bone implant |
US9993277B2 (en) | 2010-03-08 | 2018-06-12 | Conventus Orthopaedics, Inc. | Apparatus and methods for securing a bone implant |
US10321937B2 (en) | 2011-08-25 | 2019-06-18 | Medos International Sarl | Bone anchors |
US9155580B2 (en) | 2011-08-25 | 2015-10-13 | Medos International Sarl | Multi-threaded cannulated bone anchors |
US11202659B2 (en) | 2011-08-25 | 2021-12-21 | Medos International Sarl | Bone anchors |
US20160278935A1 (en) * | 2013-11-11 | 2016-09-29 | 41Medical Ag | Expandable spinal implant |
US9675466B2 (en) * | 2013-11-11 | 2017-06-13 | 41Medical Ag | Expandable spinal implant |
US10076342B2 (en) | 2013-12-12 | 2018-09-18 | Conventus Orthopaedics, Inc. | Tissue displacement tools and methods |
US10022132B2 (en) | 2013-12-12 | 2018-07-17 | Conventus Orthopaedics, Inc. | Tissue displacement tools and methods |
WO2017048980A1 (en) * | 2015-09-15 | 2017-03-23 | Entrochem, Inc. | Kits and related methods for efficient use of multi-component resin systems |
US11096864B2 (en) * | 2016-11-10 | 2021-08-24 | Medisca Pharmaceutique Inc. | Adapter for a dispensing container in a planetary mixer |
US11883359B2 (en) | 2016-11-10 | 2024-01-30 | Medisca Pharmaceutique Inc. | Adapter for use in a planetary mixer |
US10918426B2 (en) | 2017-07-04 | 2021-02-16 | Conventus Orthopaedics, Inc. | Apparatus and methods for treatment of a bone |
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