US20040134790A1 - Endoprothesis with galvanised silver layer - Google Patents

Endoprothesis with galvanised silver layer Download PDF

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Publication number
US20040134790A1
US20040134790A1 US10/468,430 US46843004A US2004134790A1 US 20040134790 A1 US20040134790 A1 US 20040134790A1 US 46843004 A US46843004 A US 46843004A US 2004134790 A1 US2004134790 A1 US 2004134790A1
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support structure
silver
wrought
gold
alloys
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US7018411B2 (en
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Georg Gosheger
Jens Sass
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Implantcast GmbH
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
    • C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
    • C23C28/00—Coating for obtaining at least two superposed coatings either by methods not provided for in a single one of groups C23C2/00 - C23C26/00 or by combinations of methods provided for in subclasses C23C and C25C or C25D
    • C23C28/02—Coating for obtaining at least two superposed coatings either by methods not provided for in a single one of groups C23C2/00 - C23C26/00 or by combinations of methods provided for in subclasses C23C and C25C or C25D only coatings only including layers of metallic material
    • C23C28/023—Coating for obtaining at least two superposed coatings either by methods not provided for in a single one of groups C23C2/00 - C23C26/00 or by combinations of methods provided for in subclasses C23C and C25C or C25D only coatings only including layers of metallic material only coatings of metal elements only
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/30—Inorganic materials
    • A61L27/306—Other specific inorganic materials not covered by A61L27/303 - A61L27/32
    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25D—PROCESSES FOR THE ELECTROLYTIC OR ELECTROPHORETIC PRODUCTION OF COATINGS; ELECTROFORMING; APPARATUS THEREFOR
    • C25D5/00—Electroplating characterised by the process; Pretreatment or after-treatment of workpieces
    • C25D5/10—Electroplating with more than one layer of the same or of different metals
    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25D—PROCESSES FOR THE ELECTROLYTIC OR ELECTROPHORETIC PRODUCTION OF COATINGS; ELECTROFORMING; APPARATUS THEREFOR
    • C25D7/00—Electroplating characterised by the article coated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A61F2002/30929—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth having at least two superposed coatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00011—Metals or alloys
    • A61F2310/00017—Iron- or Fe-based alloys, e.g. stainless steel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00011—Metals or alloys
    • A61F2310/00023—Titanium or titanium-based alloys, e.g. Ti-Ni alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00011—Metals or alloys
    • A61F2310/00029—Cobalt-based alloys, e.g. Co-Cr alloys or Vitallium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389—The prosthesis being coated or covered with a particular material
    • A61F2310/00395—Coating or prosthesis-covering structure made of metals or of alloys
    • A61F2310/00419—Other metals
    • A61F2310/0052—Coating made of silver or Ag-based alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389—The prosthesis being coated or covered with a particular material
    • A61F2310/00395—Coating or prosthesis-covering structure made of metals or of alloys
    • A61F2310/00419—Other metals
    • A61F2310/00568—Coating made of gold or Au-based alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/12—All metal or with adjacent metals
    • Y10T428/12493—Composite; i.e., plural, adjacent, spatially distinct metal components [e.g., layers, joint, etc.]
    • Y10T428/12771—Transition metal-base component
    • Y10T428/12861—Group VIII or IB metal-base component

Definitions

  • the invention relates to an endoprosthesis having a metallic support structure and to a process for producing an endoprosthesis of this type.
  • Endoprostheses having a support structure which consists partly or completely of metal are used in a wide range of medical applications, in particular (though not exclusively) in the field of bone replacement.
  • Examples are joint prostheses which are to replace a joint which is no longer functioning and modular systems which can be used to assemble endoprostheses for bone replacement as required and which are used above all in tumor surgery.
  • the endoprosthesis according to the invention has a metallic support structure, at least part of the surface of which is electroplated with silver.
  • the endoprosthesis is particularly suitable for bone replacement.
  • a layer of silver applied by electroplating bonds well to the support structure, so that the infection-inhibiting action of the endoprosthesis is maintained for a long time. Applying a layer of silver by electroplating is relatively inexpensive.
  • a wide range of cast or wrought alloys are suitable as metals for the support structure. Examples include:
  • a metallic support structure is provided, and at least part of the surface of the support structure is electroplated with silver.
  • a bonding layer which may include gold, is applied to the surface which is to be electroplated with silver. It is advantageous for the support structure to be deoxidized in the region of the surface which is to be plated with silver prior to the coating operation.
  • a support structure made from a wrought TiAlV alloy is provided.
  • the surface of this support structure which is to be plated with silver is ionically deoxidized in a vacuum chamber, and the deoxidized surface of the support structure is ionically coated with gold in a vacuum chamber.
  • the gold-coated surface of the support structure is then electroplated with silver in an electroplating bath.
  • a support structure comprising a cast CoCrMo alloy is provided, with the surface of the support structure which is to be plated with silver being deoxidized in an electroplating bath.
  • the deoxidized surface of the support structure is plated with gold in an electroplating bath, and the gold-coated surface of the support structure is plated with silver in an electroplating bath.
  • the oxide layer which is always formed under atmospheric conditions is removed by ion sputtering in a first vacuum chamber (ionic deoxidation). Then, the deoxidized surface of the support structure is ionically coated with gold (gold bombardment) in a second vacuum chamber in a plasma coating process (PVD, physical vapor deposition). The layer of gold protects the surface from being reoxidized, so that the treated support structure can be transported without problems. Finally, a layer of silver is applied to the gold-plated surface in an electroplating bath.

Abstract

Applicant submits herewith an abstract of the invention retyped on a separate page in conformation with U.S. practice. The abstract is taken from that appearing on the cover of the published international application.

Description

  • The invention relates to an endoprosthesis having a metallic support structure and to a process for producing an endoprosthesis of this type. [0001]
  • Endoprostheses having a support structure which consists partly or completely of metal are used in a wide range of medical applications, in particular (though not exclusively) in the field of bone replacement. Examples are joint prostheses which are to replace a joint which is no longer functioning and modular systems which can be used to assemble endoprostheses for bone replacement as required and which are used above all in tumor surgery. [0002]
  • When using endoprostheses of this type, it is not possible to rule out the risk of infection. Although it is in principle possible to treat endoprostheses, for example with antibiotics, poor adhesion to the surface, in particular over prolonged periods, and undesirable side effects cause problems. [0003]
  • It is known from U.S. Pat. No. 5,492,763 to use an ion implantation process to introduce metal atoms, such as silver, gold, copper, platinum, iridium, magnesium and palladium, into the surface of an implant structure which consists, for example, of a polymer material. The intention of this process is to achieve a bacteriostatic or bactericidal action. However, ion implantation processes are complex and therefore expensive. [0004]
  • It is an object of the invention to provide an inexpensive and medically harmless way of reducing the risk of infection in endoprosthesis with a metallic support structure. [0005]
  • This object is achieved by a bone replacement endoprosthesis having the features of claim [0006] 1 and a process for producing a bone replacement endoprosthesis having the features of claim 3. Advantageous configurations of the invention will emerge from the subclaims.
  • The endoprosthesis according to the invention has a metallic support structure, at least part of the surface of which is electroplated with silver. The endoprosthesis is particularly suitable for bone replacement. [0007]
  • It has been found that the risk of post-implantation infection is minimized by electroplating with silver. [0008]
  • This does not cause any serious side effects. A layer of silver applied by electroplating bonds well to the support structure, so that the infection-inhibiting action of the endoprosthesis is maintained for a long time. Applying a layer of silver by electroplating is relatively inexpensive. [0009]
  • Beneath the layer of silver there is a bonding layer which may, for example, include gold. [0010]
  • A wide range of cast or wrought alloys are suitable as metals for the support structure. Examples include: [0011]
  • cast CoCrMo alloys in accordance with ASTM F 75 or ISO 5832-4, [0012]
  • wrought CoCrMo alloys in accordance with ISO 5832-12, [0013]
  • wrought CoNiCrMo alloys in accordance with ASTM F 562 or ISO 5832-6, [0014]
  • wrought titanium alloys in accordance with ISO 5832-2, [0015]
  • wrought TiAlNb alloys in accordance with ASTM F 1295-92 or ISO 5832-11, [0016]
  • wrought TiAlV alloys in accordance with ASTM F 136 or ISO 5832-3, and [0017]
  • wrought FeCrNiMnMoNbN alloys in accordance with ISO 5832-9. [0018]
  • The choice of a suitable material for the support structure is dependent on the area of use of the endoprosthesis. In accordance with the invention, it is even possible for endoprostheses comprising metals which are not mentioned in the above list to be provided with a surface which has been electroplated with silver. [0019]
  • In the process according to the invention for producing a bone replacement endoprosthesis, a metallic support structure is provided, and at least part of the surface of the support structure is electroplated with silver. Prior to the electroplating with silver, a bonding layer, which may include gold, is applied to the surface which is to be electroplated with silver. It is advantageous for the support structure to be deoxidized in the region of the surface which is to be plated with silver prior to the coating operation. [0020]
  • In an advantageous configuration of the process, a support structure made from a wrought TiAlV alloy is provided. The surface of this support structure which is to be plated with silver is ionically deoxidized in a vacuum chamber, and the deoxidized surface of the support structure is ionically coated with gold in a vacuum chamber. The gold-coated surface of the support structure is then electroplated with silver in an electroplating bath. [0021]
  • In another preferred embodiment of the process according to the invention, a support structure comprising a cast CoCrMo alloy is provided, with the surface of the support structure which is to be plated with silver being deoxidized in an electroplating bath. The deoxidized surface of the support structure is plated with gold in an electroplating bath, and the gold-coated surface of the support structure is plated with silver in an electroplating bath. [0022]
  • The invention is explained in more detail below on the basis of exemplary embodiments.[0023]
    • EXAMPLE 1
  • In the case of a support structure made from TiAl6V4 in accordance with ISO 5832-3, the oxide layer which is always formed under atmospheric conditions is removed by ion sputtering in a first vacuum chamber (ionic deoxidation). Then, the deoxidized surface of the support structure is ionically coated with gold (gold bombardment) in a second vacuum chamber in a plasma coating process (PVD, physical vapor deposition). The layer of gold protects the surface from being reoxidized, so that the treated support structure can be transported without problems. Finally, a layer of silver is applied to the gold-plated surface in an electroplating bath. [0024]
    • EXAMPLE 2
  • In the case of a support structure made from special steel or a cast CoCrMo alloy in accordance with ISO 5832-4, the superficial oxide layer is removed by electroplating baths. Then, a gold layer can be applied in the same electroplating bath. The gold-plated surface is then electroplated with silver in a different tank. [0025]

Claims (6)

1. A bone replacement endoprosthesis, having a metallic support structure made from a cast or wrought alloy, in which at least part of the surface is electroplated with silver and a bonding layer, which preferably includes gold, is provided beneath the layer of silver, without any gold being exposed at the surface of the bone replacement endoprosthesis.
2. The bone replacement endoprosthesis as claimed in claim 1, characterized in that the support structure includes at least one material selected from the following group: cast CoCrMo alloys, wrought CoCrMo alloys, wrought CoNiCrMo alloys, wrought titanium alloys, wrought TiAlNb alloys, wrought TiAlV alloys, wrought FeCrNiMnMoNbN alloys.
3. A process for producing the bone replacement endoprosthesis as claimed in claim 1 or 2, comprising the steps of:
providing a metallic support structure made from a cast or wrought alloy,
applying a bonding layer, which preferably includes gold, to at least part of the surface of the support structure,
electroplating that part of the surface of the support structure which has been provided with the bonding layer with silver.
4. The process as claimed in claim 3, characterized in that the support structure is deoxidized in the region of the surface which is to be plated with silver prior to the coating operation.
5. The process as claimed in claim 3, comprising the steps of:
providing a support structure made from a wrought TiAlV alloy,
ionically deoxidizing the surface of the support structure which is to be plated with silver in a vacuum chamber,
ionically coating the deoxidized surface of the support structure with gold in a vacuum chamber,
electroplating the gold-coated surface of the support structure with silver in an electroplating bath.
6. The process as claimed in claim 3, comprising the steps of:
providing a support structure made from a cast CoCrMo alloy,
deoxidizing the surface of the support structure which is to be plated with silver in an electroplating bath,
electroplating the deoxidized surface of the support structure with gold in an electroplating bath,
electroplating the gold-coated surface of the support structure with silver in an electroplating bath.
US10/468,430 2001-02-19 2002-02-18 Endoprothesis with galvanised silver layer Expired - Lifetime US7018411B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10107675A DE10107675B4 (en) 2001-02-19 2001-02-19 Endoprosthesis and process for its manufacture
DE10107675.4 2001-02-19
PCT/EP2002/001705 WO2002065953A1 (en) 2001-02-19 2002-02-18 Endoprothesis with galvanised silver layer

Publications (2)

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US20040134790A1 true US20040134790A1 (en) 2004-07-15
US7018411B2 US7018411B2 (en) 2006-03-28

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US (1) US7018411B2 (en)
EP (1) EP1361837B1 (en)
AT (1) ATE342018T1 (en)
DE (2) DE10107675B4 (en)
DK (1) DK1361837T3 (en)
ES (1) ES2274022T3 (en)
PT (1) PT1361837E (en)
WO (1) WO2002065953A1 (en)

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DE10323676A1 (en) * 2003-05-15 2004-12-02 Aesculap Ag & Co. Kg Implant with long-term antibiotic effect
DE102008057026A1 (en) * 2007-11-12 2009-05-28 Medicoat Ag Implant and method for coating an implant
DE102017110398B4 (en) 2017-05-12 2023-01-26 Jürgen Degreif Method for providing medical implants
CN110369655B (en) * 2019-08-08 2020-08-21 无锡航亚科技股份有限公司 Forging method of CoCrMo tibial plateau artificial joint implant
DE102020101852A1 (en) 2020-01-27 2021-07-29 Dot Gmbh Coated medical articles and processes for their manufacture
EP4140512A1 (en) 2021-08-27 2023-03-01 Westfälische Wilhelms-Universität Münster New coating of implants
CA3227785A1 (en) 2021-08-27 2023-03-02 Martin Schulze New coating of implants

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US7018411B2 (en) 2006-03-28
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ATE342018T1 (en) 2006-11-15
DE50208411D1 (en) 2006-11-23
WO2002065953A1 (en) 2002-08-29
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PT1361837E (en) 2007-01-31

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