US20030225347A1 - Directed tissue growth employing reduced pressure - Google Patents

Directed tissue growth employing reduced pressure Download PDF

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Publication number
US20030225347A1
US20030225347A1 US10/161,076 US16107602A US2003225347A1 US 20030225347 A1 US20030225347 A1 US 20030225347A1 US 16107602 A US16107602 A US 16107602A US 2003225347 A1 US2003225347 A1 US 2003225347A1
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US
United States
Prior art keywords
tissue
cover
sub
atmospheric pressure
bone substitute
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
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US10/161,076
Inventor
Louis Argenta
Michael Morykwas
Lawrence Webb
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Wake Forest University
Wake Forest University Health Sciences
Original Assignee
Wake Forest University
Wake Forest University Health Sciences
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29583345&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=US20030225347(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wake Forest University, Wake Forest University Health Sciences filed Critical Wake Forest University
Priority to US10/161,076 priority Critical patent/US20030225347A1/en
Assigned to WAKE FOREST UNIVERSITY reassignment WAKE FOREST UNIVERSITY ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: WEBB, LAWRENCE X, ARGENTA, LOUIS C., MORYKWAS, MICHAEL J
Priority to CN2007101487397A priority patent/CN101143120B/en
Priority to PCT/US2003/016763 priority patent/WO2003101385A2/en
Priority to AU2003231870A priority patent/AU2003231870B2/en
Priority to JP2004508743A priority patent/JP4467428B2/en
Priority to ES11175725T priority patent/ES2402238T3/en
Priority to KR1020047019708A priority patent/KR101007625B1/en
Priority to EP11175725A priority patent/EP2392302B1/en
Priority to MXPA04012141A priority patent/MXPA04012141A/en
Priority to ES03756228T priority patent/ES2370817T3/en
Priority to CA2490027A priority patent/CA2490027C/en
Priority to CNB038181703A priority patent/CN100339061C/en
Priority to DK03756228.7T priority patent/DK1517660T3/en
Priority to DK11175725.8T priority patent/DK2392302T3/en
Priority to CN2013100124298A priority patent/CN103142337A/en
Priority to EP03756228A priority patent/EP1517660B1/en
Priority to BR0311584-4A priority patent/BR0311584A/en
Priority to AT03756228T priority patent/ATE521317T1/en
Assigned to WAKE FOREST UNIVERSITY HEALTH SCIENCES reassignment WAKE FOREST UNIVERSITY HEALTH SCIENCES ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: WAKE FOREST UNIVERSITY
Publication of US20030225347A1 publication Critical patent/US20030225347A1/en
Priority to ZA2004/09274A priority patent/ZA200409274B/en
Priority to IL165508A priority patent/IL165508A/en
Priority to HK05108562.6A priority patent/HK1076594A1/en
Priority to HK06103432A priority patent/HK1083441A1/en
Priority to HK08110409.6A priority patent/HK1119043A1/en
Priority to AU2009201422A priority patent/AU2009201422B2/en
Priority to JP2009188084A priority patent/JP5280969B2/en
Priority to HK12101118.1A priority patent/HK1160754A1/en
Abandoned legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/88Osteosynthesis instruments; Methods or means for implanting or extracting internal or external fixation devices
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61HPHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H9/00Pneumatic or hydraulic massage
    • A61H9/005Pneumatic massage
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M3/00Tissue, human, animal or plant cell, or virus culture apparatus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F2013/00361Plasters
    • A61F2013/00902Plasters containing means
    • A61F2013/00927Plasters containing means with biological activity, e.g. enzymes for debriding wounds or others, collagen or growth factors

Definitions

  • the present invention relates to an apparatus and method for promoting directed tissue growth, and more particularly to an apparatus and method for providing directed tissue growth within a host matrix through the application of reduced pressure to the tissue to be grown.
  • diabetes is one of pressing importance.
  • insulin treatment can prevent early death from diabetic coma, such treatment does not prevent the chronic, disabling complications of the disease.
  • diabetes mellitus is among the top 10 causes of death in the United States, and is the leading cause of blindness and uremia.
  • Type I The first type of diabetes, Type I, is caused by failure of the pancreas to secrete insulin. Normally, insulin is synthesized in the beta cells of the islets of Langerhans of the pancreas. Individuals affected with Type I diabetes have insulin deficiency due to islet cell loss. Recent medical studies have shown the transplantation of cadaver beta cells to a diabetic patient can provide the pancreas with the ability to produce insulin. However, such an approach is limited due to the lack of availability of cadaver donor cells, the need for subsequent transplants, as well as complications and side effects commonly encountered in transplantation, such as the need for continued use of antirejection drugs. The ability to provide directed tissue growth of beta cells within the pancreas, or externally to the pancreas for transplantation into the pancreas, would therefore be a significant advance the treatment of diseases such as diabetes.
  • a directed tissue growth apparatus for growing tissue by applying a tissue growth medium to the tissue and applying a reduced, sub-atmospheric pressure at the growth medium and the tissue in a controlled manner for a selected time period.
  • the application of reduced pressure at the growth medium and tissue promotes growth of the tissue within the tissue growth medium, which provides benefits such as accelerated healing rates and replacement of missing, diseased, or damaged tissue.
  • Tissues that may exhibit a positive response to treatment by the application of reduced pressure include bone, cartilage, tendon, nerves, skin, breast tissue, and organs such as the liver or pancreas, for example.
  • the directed tissue growth apparatus in accordance with the present invention includes a reduced pressure application appliance which is applied to a treatment site where tissue is to be grown.
  • a treatment site may be located in vivo or in vitro.
  • the reduced pressure application appliance may include a tissue growth medium for placement in contact with the tissue to be grown to provide a medium into which cells may be grown.
  • the form of the tissue growth medium is selected with regard to the type of tissue to be grown.
  • the tissue growth medium may comprise a layer of material suitable for use as artificial skin to replace damaged or missing skin.
  • the tissue growth medium may conveniently comprise a bioabsorbable material.
  • a bioabsorbable material is a material that may dissolve in the tissue or which may be incorporated in the tissue as a substantially indistinguishable component.
  • the tissue growth medium may also comprise a porous scaffold or matrix, which may include one or more of a naturally occurring fibrous or fibrous-proteinaceous material, such as collagen, or a synthetic resorbable material.
  • the scaffold may comprise a bone substitute material, such as a bioglass or ceramic.
  • Porous materials permit growth of cells within the pores of the material and permit gas flow to the tissue during times of non-application of reduced pressure.
  • the porous materials facilitate distribution of sub-atmospheric pressure and fluid flow.
  • an open-cell foam section for connection to a source of reduced pressure, may be provided in contact with a selected tissue growth medium to apply a reduced pressure to the tissue growth medium.
  • the open-cell foam section may desirably be used with a particular tissue growth medium such as artificial skin, to better apply and distribute sub-atmospheric pressure across the skin surface.
  • the appliance also includes a cover for covering and enclosing the tissue and the tissue growth medium.
  • the cover also functions to cover and enclose the open-cell foam section, when used.
  • the appliance may also include sealing means for sealing the cover to the region surrounding the tissue to be grown in order to maintain reduced pressure in the vicinity of the tissue during tissue growth.
  • the sealing means may be in the form of an adhesive applied to the underside of the cover or at least to the periphery of the underside of the cover for sealing the cover to the region surrounding the tissue.
  • the sealing means may also include a separate sealing member, such as an adhesive strip, a sealing ring, a tubular pad or an inflatable cuff, for use with the cover for positioning around the region surrounding the tissue to be grown.
  • the reduced pressure within the sealed enclosure beneath the cover may serve to self adhere and seal the cover in position at the tissue growth site.
  • the reduced pressure appliance may also include a suction port for enabling reduced pressure to be supplied within the sealed volume enclosed beneath the cover.
  • the suction port may be in the form of a nipple on the cover.
  • the suction port may be in the form of a tube attached to the cover.
  • the port may be provided at the mouth of a suction tube that is inserted beneath the cover.
  • a vacuum system is connected with the reduced pressure appliance in order to provide suction or reduced pressure to the appliance.
  • the vacuum system includes a suction pump or suction device for connection with the suction port of the appliance for producing the reduced pressure over the tissue site.
  • the vacuum system may include a section of hose or tube, such as a vacuum hose, that interconnects the suction device with the suction port of the appliance to provide the reduced pressure at the tissue site.
  • a tube of the appliance may serve as the vacuum hose for connection with the suction device.
  • a mouth of the suction hose may serve as the suction port in applications where the suction hose is not connected to a separate port.
  • a collection device in the form of a fluid trap may be provided intermediate the vacuum hose of the suction device and the suction port of the appliance to trap any exudate which may be aspirated from the tissue by the reduced pressure appliance.
  • a stop mechanism may also be provided for the vacuum system to halt application of the reduced pressure at the tissue site in the event that a predetermined quantity of exudate has been collected.
  • the apparatus may also include a control device for controlling the pump and for providing intermittent or cyclic production of reduced pressure.
  • the cover for the reduced pressure appliance may be in the form of a gas impermeable covering sheet of flexible polymer material, such as polyurethane, having an adhesive backing that provides the seal for securing the sheet over the tissue site to provide a gas-tight or fluid-tight sealed enclosure over the tissue site.
  • a semi-permeable cover may also be used in selected applications.
  • the vacuum system of the tissue treatment apparatus may include a suction pump having a vacuum hose that is connected with or, alternatively, integral with, a suction tube serving as a suction port for the appliance.
  • the suction tube for the appliance runs beneath the cover sheet when sealed in position over the tissue site and into the fluid-tight enclosure provided at the tissue site beneath the cover sheet.
  • the suction tube is connected to a section of open-cell foam in communication with the tissue growth medium into which the tissue may be grown.
  • the tissue growth medium may take the form of a layer of skin-substitute material, for example.
  • the open-cell foam functions to more uniformly apply reduced pressure or suction over the tissue growth medium.
  • the open cell foam section communicates the reduced pressure to the tissue site under the cover sheet while holding the cover sheet substantially out of contact with the tissue during the application of reduced pressure at the enclosed tissue site.
  • the tissue growth medium may comprise a porous structure, such as a bone substitute material. In such a case, the suction tube may be connected directly with the tissue growth medium, and the open-cell foam section may be omitted.
  • a method of treating tissue damage comprises applying a reduced pressure to a tissue to be grown over an area sufficient to promote the growth of new cells within a tissue growth medium and/or the tissue.
  • the method of growing a tissue comprises providing a tissue growth medium proximate the tissue to be grown.
  • a reduced pressure is subsequently applied to the tissue growth medium and the tissue.
  • the reduced pressure is maintained until the tissue has progressed toward a selected stage of growth in the medium.
  • the reduced pressure may be provided in alternating periods of application and non-application of the reduced pressure.
  • the application of reduced pressure comprises the steps of placing a tissue growth medium in contact with a tissue to be grown; locating a cover over the tissue; sealing the cover about the tissue to form a reduced pressure chamber; and operably connecting the cover or at least the reduced pressure chamber with a vacuum system for producing the reduced pressure.
  • the method includes maintaining the reduced pressure until the tissue has progressed toward a selected stage of growth within the tissue growth medium.
  • FIG. 1 is a schematic cross-sectional view of a reduced pressure appliance comprising a porous tissue growth medium, a flexible hose for connecting the tissue growth medium with a vacuum system, and an adhesive-backed flexible polymer sheet overlying the growth medium to provide a seal over a tissue to be grown; and
  • FIG. 2 is a schematic cross-sectional view of a reduced pressure appliance comprising a foam section in communication with a tissue growth medium, a flexible hose for connecting the foam section with a vacuum system, and an adhesive-backed flexible polymer sheet overlying the growth medium-foam section assembly to provide a seal over a tissue to be grown.
  • a directed tissue growth apparatus for promoting growth in a tissue by application of reduced pressure (i.e., below atmospheric pressure) so that suction may be applied to a tissue site in a controlled manner for a selected time period.
  • reduced pressure i.e., below atmospheric pressure
  • a directed tissue growth apparatus having a reduced pressure appliance 29 for enclosing a tissue site to provide a fluid-tight or gas-tight enclosure over the tissue site to grow tissue 24 in a tissue growth medium 10 through the application of sub-atmospheric pressure.
  • the directed tissue growth apparatus 25 includes a reduced pressure appliance, generally designated 29 , which is applied to and sealed over a tissue site in order to enclose the tissue site to form a reduced pressure chamber about the tissue site for treatment with suction or reduced pressure within a sealed generally fluid-tight or gas-tight enclosure.
  • the appliance 29 is connected with a vacuum system, generally designated 30 , to provide a source of suction or reduced pressure for the sealed appliance 29 at the tissue site.
  • the vacuum system 30 may include a suction device 31 and an optional fluid collection device 32 intermediate the hose 12 and suction device 31 .
  • the fluid collection device 32 functions to collect any exudate that may be aspirated from the tissue.
  • a stop mechanism 33 may be provided to halt application of the suction device 31 upon collection of a predetermined quantity of fluid in the fluid collection device 32 .
  • the appliance 29 includes a fluid-impermeable tissue cover 18 in the form of a flexible, adhesive, fluid impermeable polymer sheet for covering and enclosing the tissue 24 at the tissue site.
  • the tissue cover 18 includes an adhesive backing 20 which functions to seal the tissue cover about the periphery of the tissue 24 to provide a generally gas-tight or fluid-tight enclosure over the tissue 24 .
  • the adhesive cover sheet 18 must have sufficient adhesion to form a fluid-tight or gas-tight seal 19 around the tissue 24 and to hold the sheet 18 in sealed contact at the attachment site during the application of suction or reduced pressure.
  • the cover 18 may be provided in the form of a rigid or semi-rigid cover adapted to form a fluid-tight or gas-tight seal around the tissue. Suitable modifications may be made to the appliance to provide a reduced pressure chamber for treating the selected tissue.
  • the appliance 29 also includes a porous tissue growth medium 10 which is positioned under the cover 18 on or in the tissue 24 .
  • the tissue growth medium 10 is disposed over a sufficient expanse of the tissue 24 to promote sufficient growth of new tissue cells within the tissue growth medium 10 .
  • the tissue growth medium 10 should be sufficiently porous to allow for connection to a vacuum system 30 to supply sub-atmospheric pressure to the tissue 24 and the tissue growth medium 10 .
  • the tissue growth medium 10 may also be perforated to enhance gas flow and to reduce the weight of the appliance.
  • the configuration and composition of the tissue growth medium 10 can be adjusted to suit the particular tissue type.
  • the tissue growth medium 10 may comprise a natural, synthetic, or natural-synthetic hybrid porous material.
  • tissue growth medium 10 may conveniently be chosen to provide a scaffold to support or direct osteoconduction, i.e. bone formation.
  • a tissue growth medium 10 may be selected from materials which induce differentiation of stem cells to osteogenic cells, i.e. osteoinductive agents, or materials which provide stem cells, e.g. bone marrow aspirate.
  • a tissue growth medium 10 for use in bone growth may be a bioglass, ceramic material, or other natural or synthetic porous material.
  • materials comprising calcium sulphate or calcium phosphate are suited for use as a bone tissue growth medium 10 .
  • a calcium sulfate bone substitute is completely absorbed by osteoclasts, and osteoblasts will attach to the calcium sulfate bone substitute and lay osteoid on it. The process of absorption by osteoclasts is complete and quick. Hence, it can be used with antibiotics in presence of infection.
  • a chief advantage is that a calcium sulfate bone substitute can be used in presence of infection as well as being one of the least expensive bone substitutes.
  • Calcium sulphate bone substitutes principally possess osteoconductive properties and no osteoinductive properties, though such a material could be modified to provide osteoinductive properties.
  • One suitable calcium sulphate bone substitute is OSTEOSET® Bone Graft Substitute, a product of Wright Medical Technology, Inc. of Arlington Tenn.
  • Another class of suitable materials is one comprising various derivates of calcium phosphate, which can be used to provide a structural matrix for osteoconduction. These derivatives also do not possess any osteoinductive properties.
  • the commonly used derivates are: hydroxyapatite (coral based or chemically derived synthetic ceramic), fluorapatite, tri-calcium phosphate, bioglass ceramics and combinations thereof.
  • One suitable calcium phosphate bone substitute is OsteoGraftTM Bone Graft Substitute, a product of Millenium Biologix of Springfield, Ontario, Canada.
  • the appliance 29 also includes a suction port in the form of a hollow suction tube 12 that connects either directly or indirectly with the vacuum system 30 to provide suction within the sealed enclosure.
  • the outlet of suction tubing 12 serves as a suction port for the appliance 29 .
  • An end segment 12 a of the tubing 12 is embedded within the tissue growth medium 10 for providing suction or reduced pressure within the chamber provided under the tissue cover 18 .
  • the open-cell structure of the tissue growth medium 10 also permits the tissue growth medium 10 to distribute the reduced pressure within the chamber.
  • tissue growth medium 10 Embedding the open end of segment 12 a of tubing 12 within the interior of the tissue growth medium 10 permits the tissue growth medium 10 to function as a shield to help prevent the tissue cover 18 from being inadvertently sucked into occlusive engagement with the open end of the tube thereby plugging the tube 12 and restricting gas flow.
  • the open-cell structure of the tissue growth medium 10 also permits the tissue growth medium 10 to distribute the reduced pressure within the sealed enclosure.
  • the tube segment 12 a embedded within the tissue growth medium 10 optionally has at least one side port 14 for positioning within the interior of the tissue growth medium 10 to promote substantially uniform application of reduced pressure throughout the enclosure. Positioning the side port 14 of tube segment 12 a within the interior of the tissue growth medium 10 permits the tissue growth medium 10 to also function as a shield for the side port to thereby prevent the tissue cover 18 from being sucked into the side port 14 and thereby restricting gas flow.
  • the open cells of the tissue growth medium 10 facilitate growth of tissue therein and facilitate gas flow throughout the enclosure.
  • the tissue growth medium 10 functions to hold the tissue cover 18 generally out of contact with the tissue 24 during the application of suction within the enclosure.
  • Tubing 12 and tube segment 12 a may be sufficiently flexible to permit movement of the tubing but are sufficiently rigid to resist constriction when reduced pressure is supplied to the appliance 29 or when the location of the tissue is such that the patient must sit or lie upon the tubing 12 or upon the reduced pressure appliance 29 .
  • the assembly comprising the tissue growth medium 10 and the tube 12 may be fabricated by snaking the end of the tube segment 12 a through an internal passageway in the tissue growth medium 10 such as by pulling the end of the tube segment 12 a through the passageway using forceps.
  • the assembly is preferably prepared prior to use under sterile conditions and then stored in an aseptic package.
  • the flexible, fluid-impermeable, adhesive tissue cover sheet 18 is secured in position at the tissue site, overlying the tissue growth medium 10 disposed in contact with the tissue 24 .
  • the tissue cover sheet 18 is secured and sealed to the attachment site 22 by an adhesive layer 20 on the under surface of the tissue cover 18 to form a gas-tight seal 19 about the tissue 24 .
  • the tissue cover 18 also provides a gas-tight seal around the tubing 12 at the feedthrough location 22 a where the tubing 12 emerges from beneath the tissue cover 18 .
  • the tissue cover 18 is preferably formed of a fluid impermeable or gas impermeable flexible adhesive sheet such as Ioban, a product of the 3M Corporation of Minneapolis, Minn.
  • Predetermined amounts of suction or reduced pressure may be produced by the vacuum system 30 .
  • the vacuum system 30 is preferably controlled by a control device or control circuitry that includes a switch or a timer which may be set to provide cyclic on/off operation of the vacuum system 30 according to user-selected intervals. Alternatively, the vacuum system 30 may be operated continuously without the use of a cyclical timer.
  • the control may also include a pressure selector to enable the amount of suction produced by the system to be adjusted so that a suitable sub-atmospheric pressure may be created within the chamber. Operation of the vacuum system 30 may be controlled to permit graduated increases in the amount of vacuum applied or graduated decreases in the amount of vacuum applied.
  • FIG. 2 an alternative configuration of the reduced pressure appliance 129 is shown which is similar to the reduced pressure appliance 29 of FIG. 1.
  • the elements of the appliance 129 of FIG. 2 which are similar to like elements depicted in FIG. 1 utilize the same reference number as used in FIG. 1 but with a 100-series added to such reference numerals.
  • a principal difference between the reduced pressure appliance 129 of FIG. 2 and that of FIG. 1 is that a porous open-cell foam section 111 is provided for communication with the vacuum system 130 .
  • the open-cell foam section 111 in turn communicates with the tissue growth medium 110 , which may or may not be porous.
  • the directed tissue growth apparatus 125 includes a reduced pressure appliance, generally designated 129 , which is applied to and sealed over a tissue site in order to enclose the tissue site for treatment with suction or reduced pressure within a sealed generally fluid-tight or gas-tight enclosure.
  • a vacuum system generally designated 130
  • the appliance 129 includes a fluid-impermeable tissue cover 118 in the form of a flexible, fluid impermeable polymer sheet for covering and enclosing the tissue 124 at the tissue site.
  • the tissue cover 118 may include an adhesive backing 120 at least around the periphery of the cover which functions to seal the tissue cover proximate to the tissue 124 to provide a generally gas-tight or fluid-tight enclosure over the tissue 124 .
  • the adhesive cover sheet 118 must have sufficient adhesion to form a fluid-tight or gas-tight seal 119 around the tissue 124 and to hold the sheet 118 in sealed contact with the attachment site around the tissue 124 during the application of suction or reduced pressure.
  • the cover 118 may also be provided in the form of a rigid or semi-rigid cover which cooperates with a suitable seal to form a fluid-tight or gas-tight seal around the tissue.
  • the appliance 129 also includes a porous open-cell foam section 111 which is placed under the cover 118 and in direct or indirect contact with a tissue growth medium 110 .
  • the open-cell foam section 111 should be sufficiently porous to allow for connection to the vacuum system 130 to transmit sub-atmospheric pressure to the tissue 124 and the tissue growth medium 110 .
  • the tissue growth medium 110 is placed over a sufficient expanse of the tissue 124 to promote sufficient growth of new tissue cells within the tissue growth medium 110 .
  • the tissue growth medium 110 and/or the foam section 111 may also be perforated or channeled to enhance gas flow and to reduce the weight of the appliance. The configuration depicted in FIG.
  • a skin substitute material may comprise a multilayer structure having, for example, a layer of collagen for contact with the tissue to be grown and a silicone layer disposed on top of the collagen layer for contact with the foam section 111 .
  • a suitable skin substitute material is INTEGRA® Dermal Regeneration Template, a product of Integra LifeSciences Corp. of Plainsboro, N.J.
  • the silicone layer provides a removable backing to support the collagen layer during tissue ingrowth. After growth has continued to a desired stage, the silicone layer may be removed from the collagen layer, leaving the neodermis in place, onto which a thin split thickness skin graft may be placed.
  • the growth medium 110 can be formed for the purpose of growing an organ, such as the pancreas or liver.
  • the growth medium 110 may take the form of a scaffold/matrix of either a naturally occurring molecule (e.g., collagen) or of resorbable materials (e.g., polyglycolic acid or polygalactic acid or a combination thereof).
  • the growth medium 110 may be formed from commercially available screens which are layered to the desired thickness.
  • the appliance 129 also includes a suction port in the form of a hollow suction tube 112 , similar to the tube 12 of FIG. 1, that connects with the vacuum system 130 to provide suction within the sealed enclosure.
  • the suction tubing 112 provides at least one suction port for the appliance 129 .
  • an end segment 112 a of the tubing 112 is embedded within the foam section 111 , rather than in the tissue growth material, for providing suction or reduced pressure within the enclosure provided under the tissue cover 118 .
  • the open-cell structure of the foam section 111 permits the foam section 111 to distribute the reduced pressure within the enclosure.
  • Embedding the open end of segment 112 a of tubing 112 within the interior of the foam section 111 permits the foam section 111 to function as a shield to help prevent the tissue cover 118 from being inadvertently sucked into the open end of the tube thereby plugging the tube 112 and restricting gas flow.
  • the open-cell structure of the foam section 111 also permits the foam section 111 to distribute the pressure within the sealed enclosure.
  • the tube segment 112 a embedded within the foam section 111 preferably has at least one side port 114 for positioning within the interior of the foam section 111 to promote substantially uniform application of reduced pressure throughout the enclosure. Positioning the side port 114 of tube segment 112 a within the interior of the foam section 111 permits the foam section 111 to function as a shield for the side port to thereby prevent the tissue cover 118 from being sucked into the side port 114 and thereby restricting gas flow.
  • the open cells of the foam section 111 facilitate gas flow throughout the enclosure.
  • the foam section 111 functions to hold the tissue cover 118 generally out of contact with the tissue 124 during the application of suction within the enclosure.
  • the flexible, fluid-impermeable, adhesive tissue cover sheet 118 of appliance 129 is secured, during use, in position at the tissue site, overlying the foam section 111 and tissue growth medium 110 which contacts the tissue 124 .
  • the tissue cover sheet 118 is secured and sealed to the attachment site 122 by an adhesive layer 120 on the under surface of the tissue cover 118 to form a gas-tight seal 119 about the tissue 124 .
  • the tissue cover 118 also provides a gas-tight seal around the tubing 112 at the feedthrough location 122 a where the tubing 112 emerges from beneath the tissue cover 118 .
  • Reduced pressure appliances are useful for growing a variety of tissues. Directed growth of a tissue can be carried out by securing a reduced pressure appliance to the treatment site as previously shown and described, and then maintaining a substantially continuous or cyclical reduced pressure within the appliance until the newly grown tissue has reached a desired degree of development.
  • the method may be practiced using a subatmospheric pressure ranging from about 0.5 to about 0.98 atmospheres, and more specifically about 0.73 atmospheres to about 0.95 atmospheres, and more preferably practiced using a subatmospheric pressure ranging between about 0.8 to about 0.9 atmospheres.
  • the time period for use of the method on a tissue may preferably be at least 48 hours, but can, for example, be extended for multiple days. Satisfactory growth of various types of tissues has been obtained via the use of reduced pressures equivalent to about 1 to 8 in. Hg below atmospheric pressure.
  • Supplying reduced pressure to the appliance in an intermittent or cyclic manner may be desirable for growing tissues. Intermittent or cyclic supply of reduced pressure to an appliance may be achieved by manual or automatic control of the vacuum system.
  • a cycle ratio, the ratio of “on” time to “off” time, in such an intermittent reduced pressure treatment may be as low as 1:10 or as high as 10:1. The preferred ratio is approximately 5 minutes on which is usually accomplished in alternating intervals of 5 minutes of reduced pressure supply and 2 minutes of non-supply.
  • a suitable vacuum system includes any suction pump capable of providing at least 5 mm of Hg of suction to the tissue, and preferably up to 125 mm of Hg suction, and most preferably up to approximately 200 mm of Hg of suction or even higher as necessary to achieve subatmospheric pressures of about 0.5 atmospheres.
  • the pump can be any ordinary suction pump suitable for medical purposes that is capable of providing the necessary suction.
  • the dimension of the tubing interconnecting the pump and the reduced pressure appliance is controlled by the pump's ability to provide the suction level needed for operation. For example, a 1 ⁇ 4 inch diameter tube may be suitable.
  • the present invention also includes a method of growing tissue which comprises the steps of applying reduced pressure to a tissue for a selected time and at a selected magnitude sufficient to promote cell growth in a matrix or scaffold material. Further features of the apparatus and method for use thereof shall be made apparent in the following example.
  • This example was designed to demonstrate the effectiveness of the method of the invention for accelerating the rate of vascular ingrowth in a skin substitute material.
  • a directed tissue growth apparatus of the type shown in FIG. 2 comprising INTEGRA® Dermal Regeneration Template was applied to the wound site on one side of each animal.
  • An INTEGRA® Dermal Regeneration Template was applied to the wound site on the other side of each animal.
  • the INTEGRA® Dermal Regeneration Template was applied according the manufacturer's directions. Vacuum (125 mm Hg, continuous) was applied to the directed tissue growth apparatus positioned on the selected wound sites on one side of the pigs.
  • the INTEGRA® Dermal Regeneration Template at the non-vacuum-treated wound site required a force of 1.25 ⁇ 10 5 +/ ⁇ 0.51 ⁇ 10 5 dynes to separate the template from the wound site.
  • the INTEGRA® Dermal Regeneration Template at the vacuum-treated wound site required a greater force of 2.25 ⁇ 10 5 +/ ⁇ 0.51 ⁇ 10 5 dynes to separate the vacuum-treated template from the wound site.
  • the increased pull force required at the vacuum-treated wound site indicated increased ingrowth of vasculature in the skin substitute material due to the vacuum treatment.
  • the increased vascular ingrowth was confirmed by micrographs of the vacuum-treated and non-vacuum-treated pieces of INTEGRA® Dermal Regeneration Template removed from the animals.

Abstract

A tissue growth apparatus and method are provided for growing tissue by applying a tissue growth medium to the tissue and applying reduced, sub-atmospheric pressure at the growth medium and the tissue in a controlled manner for a selected time period. The application of reduced pressure at the growth medium and tissue promotes growth of the tissue within the tissue growth medium. The apparatus includes a tissue cover sealed over a tissue site. The apparatus also includes a tissue growth medium located beneath the tissue cover and in contact with the tissue to be grown. A vacuum pump supplies suction within the tissue cover over the tissue site to provide reduced pressure to the tissue and the tissue growth medium.

Description

    FIELD OF THE INVENTION
  • The present invention relates to an apparatus and method for promoting directed tissue growth, and more particularly to an apparatus and method for providing directed tissue growth within a host matrix through the application of reduced pressure to the tissue to be grown. [0001]
  • BACKGROUND OF THE INVENTION
  • Promoting the growth of tissue, especially tissue damaged through trauma or disease, has long been an area of concern in medical practice. Such damage or disease, including complications due to infection, may hinder or prevent healing of an injury due to a lack of healthy tissue growth. Many diseases and certain injuries involve affected tissue that cannot heal spontaneously. Such is the case, for example, for an open pilon fracture of bone tissue. Historically, a pilon fracture involves a high complication rate. Such complications include infection, nonunion, failure to obtain or maintain a reduction of the joint surface, and early and late arthritis. Under such conditions, failure to achieve sufficient healing of the pilon fracture could necessitate amputation. [0002]
  • In the 1970s and early 1980s the prescribed treatment for most pilon fracture injuries was open reduction and internal fixation, usually with a metaphysical bone graft. Reports of high complication rates with this approach prompted many surgeons to use indirect methods such as bridging external fixation and to limit the surgery to what was necessary for the joint reduction. Awareness of the issues of timing has prompted some to use a staged procedure, with bridging external fixation initially, followed by open but limited surgery. The incisions are dictated by fracture patterns, and the timing is dictated by resolution of the soft tissue envelope. [0003]
  • However, despite these approaches, cases arise where a major complication, e.g., a deep infection, can develop. Depending on the patient's medical condition, such as the condition of local blood vessels, customary treatment by application of a free muscle flap may be inappropriate. In such instances, traditional treatment offers a poor prognosis for salvage of the affected tissue. In such cases, where there is a likelihood of an infected nonunion and its associated pain, deformity and poor function, amputation is the appropriate and preferred medical treatment. Thus, it could be a great advance to the medical practice to provide an apparatus and method to promote healthy bone tissue growth under such circumstances to avoid the drastic treatment of amputation. [0004]
  • As further example, diseases such as cancer often result in tissue damage that does not heal spontaneously, and treatment of such resulting tissue damage would benefit from an apparatus and method to promote tissue growth. For example, many patients who experience injuries or suffer from bone cancer require replacement of a missing piece of bone. Current techniques for bone replacement include: moving a piece of the bone from an uninjured site to the injured site; use of cadaver bone; or the use of metal rods or plates. These options are not always possible due to the potential for defect from the bone donor site, or the lack of availability of cadaver bone. Hence, growth of new healthy bone tissue would provide a valuable treatment option in such cases. [0005]
  • In addition to growth of bone tissue, growth of other body tissues such as cartilage, skin, tendon, nerves, breast-tissue, and organs such as the liver or pancreas, would provide a valuable advance in the medical practice. Many diseases exist which damage the tissue of an organ beyond the ability of the body to naturally repair such damage. For example, chronic injury to the liver through viral infection or other causes can ultimately lead to cirrhosis of the liver. As cirrhosis progresses healthy tissue is replaced with fibrous tissue. The blood vessels thicken and their channels may become obliterated, which reduces blood flow in the organ. The normal structure of the internal tissue is lost, and only nonfunctioning scar tissue remains. The lack of healthy tissue eventually leads to death. It would be a great advance to promote growth of remaining healthy tissue in the liver in combination with treatment for the underlying cause of the cirrhosis. [0006]
  • Moreover, many other diseases exist which are caused by damage to tissues of an organ, of which, diabetes is one of pressing importance. Presently, the number of individuals with diabetes doubles every 15 years. While insulin treatment can prevent early death from diabetic coma, such treatment does not prevent the chronic, disabling complications of the disease. Currently, diabetes mellitus is among the top 10 causes of death in the United States, and is the leading cause of blindness and uremia. [0007]
  • The first type of diabetes, Type I, is caused by failure of the pancreas to secrete insulin. Normally, insulin is synthesized in the beta cells of the islets of Langerhans of the pancreas. Individuals affected with Type I diabetes have insulin deficiency due to islet cell loss. Recent medical studies have shown the transplantation of cadaver beta cells to a diabetic patient can provide the pancreas with the ability to produce insulin. However, such an approach is limited due to the lack of availability of cadaver donor cells, the need for subsequent transplants, as well as complications and side effects commonly encountered in transplantation, such as the need for continued use of antirejection drugs. The ability to provide directed tissue growth of beta cells within the pancreas, or externally to the pancreas for transplantation into the pancreas, would therefore be a significant advance the treatment of diseases such as diabetes. [0008]
  • SUMMARY OF THE INVENTION
  • In accordance with the present invention a directed tissue growth apparatus is provided for growing tissue by applying a tissue growth medium to the tissue and applying a reduced, sub-atmospheric pressure at the growth medium and the tissue in a controlled manner for a selected time period. The application of reduced pressure at the growth medium and tissue promotes growth of the tissue within the tissue growth medium, which provides benefits such as accelerated healing rates and replacement of missing, diseased, or damaged tissue. Tissues that may exhibit a positive response to treatment by the application of reduced pressure include bone, cartilage, tendon, nerves, skin, breast tissue, and organs such as the liver or pancreas, for example. [0009]
  • The directed tissue growth apparatus in accordance with the present invention includes a reduced pressure application appliance which is applied to a treatment site where tissue is to be grown. Such a treatment site may be located in vivo or in vitro. The reduced pressure application appliance may include a tissue growth medium for placement in contact with the tissue to be grown to provide a medium into which cells may be grown. The form of the tissue growth medium is selected with regard to the type of tissue to be grown. For example, the tissue growth medium may comprise a layer of material suitable for use as artificial skin to replace damaged or missing skin. In such a case, the tissue growth medium may conveniently comprise a bioabsorbable material. A bioabsorbable material is a material that may dissolve in the tissue or which may be incorporated in the tissue as a substantially indistinguishable component. The tissue growth medium may also comprise a porous scaffold or matrix, which may include one or more of a naturally occurring fibrous or fibrous-proteinaceous material, such as collagen, or a synthetic resorbable material. For example, the scaffold may comprise a bone substitute material, such as a bioglass or ceramic. Porous materials permit growth of cells within the pores of the material and permit gas flow to the tissue during times of non-application of reduced pressure. In addition, during times when the sub-atmospheric pressure is applied to such porous materials, the porous materials facilitate distribution of sub-atmospheric pressure and fluid flow. [0010]
  • Optionally, an open-cell foam section, for connection to a source of reduced pressure, may be provided in contact with a selected tissue growth medium to apply a reduced pressure to the tissue growth medium. For example, the open-cell foam section may desirably be used with a particular tissue growth medium such as artificial skin, to better apply and distribute sub-atmospheric pressure across the skin surface. [0011]
  • The appliance also includes a cover for covering and enclosing the tissue and the tissue growth medium. The cover also functions to cover and enclose the open-cell foam section, when used. In applications where the cover is not self-sealing by suction, the appliance may also include sealing means for sealing the cover to the region surrounding the tissue to be grown in order to maintain reduced pressure in the vicinity of the tissue during tissue growth. When the cover is sealed in position over the tissue site, a generally fluid-tight or gas-tight sealed enclosure is formed over or about the tissue site. The sealing means may be in the form of an adhesive applied to the underside of the cover or at least to the periphery of the underside of the cover for sealing the cover to the region surrounding the tissue. The sealing means may also include a separate sealing member, such as an adhesive strip, a sealing ring, a tubular pad or an inflatable cuff, for use with the cover for positioning around the region surrounding the tissue to be grown. In selected embodiments, the reduced pressure within the sealed enclosure beneath the cover may serve to self adhere and seal the cover in position at the tissue growth site. The reduced pressure appliance may also include a suction port for enabling reduced pressure to be supplied within the sealed volume enclosed beneath the cover. The suction port may be in the form of a nipple on the cover. Alternatively, the suction port may be in the form of a tube attached to the cover. As yet another alternative, the port may be provided at the mouth of a suction tube that is inserted beneath the cover. [0012]
  • A vacuum system is connected with the reduced pressure appliance in order to provide suction or reduced pressure to the appliance. For this purpose, the vacuum system includes a suction pump or suction device for connection with the suction port of the appliance for producing the reduced pressure over the tissue site. The vacuum system may include a section of hose or tube, such as a vacuum hose, that interconnects the suction device with the suction port of the appliance to provide the reduced pressure at the tissue site. A tube of the appliance may serve as the vacuum hose for connection with the suction device. Further, a mouth of the suction hose may serve as the suction port in applications where the suction hose is not connected to a separate port. [0013]
  • A collection device in the form of a fluid trap may be provided intermediate the vacuum hose of the suction device and the suction port of the appliance to trap any exudate which may be aspirated from the tissue by the reduced pressure appliance. A stop mechanism may also be provided for the vacuum system to halt application of the reduced pressure at the tissue site in the event that a predetermined quantity of exudate has been collected. The apparatus may also include a control device for controlling the pump and for providing intermittent or cyclic production of reduced pressure. [0014]
  • In a particular embodiment of the invention, the cover for the reduced pressure appliance may be in the form of a gas impermeable covering sheet of flexible polymer material, such as polyurethane, having an adhesive backing that provides the seal for securing the sheet over the tissue site to provide a gas-tight or fluid-tight sealed enclosure over the tissue site. A semi-permeable cover may also be used in selected applications. The vacuum system of the tissue treatment apparatus may include a suction pump having a vacuum hose that is connected with or, alternatively, integral with, a suction tube serving as a suction port for the appliance. The suction tube for the appliance runs beneath the cover sheet when sealed in position over the tissue site and into the fluid-tight enclosure provided at the tissue site beneath the cover sheet. An adhesive backing on the cover sheet is used to provide a fluid-tight seal around the feedthrough for the suction tube at the tissue site. Within the enclosure, the suction tube is connected to a section of open-cell foam in communication with the tissue growth medium into which the tissue may be grown. The tissue growth medium may take the form of a layer of skin-substitute material, for example. The open-cell foam functions to more uniformly apply reduced pressure or suction over the tissue growth medium. Likewise, the open cell foam section communicates the reduced pressure to the tissue site under the cover sheet while holding the cover sheet substantially out of contact with the tissue during the application of reduced pressure at the enclosed tissue site. Alternatively, the tissue growth medium may comprise a porous structure, such as a bone substitute material. In such a case, the suction tube may be connected directly with the tissue growth medium, and the open-cell foam section may be omitted. [0015]
  • A method of treating tissue damage is also provided which comprises applying a reduced pressure to a tissue to be grown over an area sufficient to promote the growth of new cells within a tissue growth medium and/or the tissue. The method of growing a tissue comprises providing a tissue growth medium proximate the tissue to be grown. A reduced pressure is subsequently applied to the tissue growth medium and the tissue. The reduced pressure is maintained until the tissue has progressed toward a selected stage of growth in the medium. The reduced pressure may be provided in alternating periods of application and non-application of the reduced pressure. [0016]
  • More specifically, the application of reduced pressure comprises the steps of placing a tissue growth medium in contact with a tissue to be grown; locating a cover over the tissue; sealing the cover about the tissue to form a reduced pressure chamber; and operably connecting the cover or at least the reduced pressure chamber with a vacuum system for producing the reduced pressure. In specific application, the method includes maintaining the reduced pressure until the tissue has progressed toward a selected stage of growth within the tissue growth medium.[0017]
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • The foregoing summary, as well as the following detailed description of the preferred embodiments of the present invention, will be better understood when read in conjunction with the appended drawings, in which: [0018]
  • FIG. 1 is a schematic cross-sectional view of a reduced pressure appliance comprising a porous tissue growth medium, a flexible hose for connecting the tissue growth medium with a vacuum system, and an adhesive-backed flexible polymer sheet overlying the growth medium to provide a seal over a tissue to be grown; and [0019]
  • FIG. 2 is a schematic cross-sectional view of a reduced pressure appliance comprising a foam section in communication with a tissue growth medium, a flexible hose for connecting the foam section with a vacuum system, and an adhesive-backed flexible polymer sheet overlying the growth medium-foam section assembly to provide a seal over a tissue to be grown.[0020]
  • DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS
  • In accordance with the present invention, a directed tissue growth apparatus is provided for promoting growth in a tissue by application of reduced pressure (i.e., below atmospheric pressure) so that suction may be applied to a tissue site in a controlled manner for a selected time period. [0021]
  • Referring to FIG. 1, a directed tissue growth apparatus, generally designated [0022] 25, is depicted having a reduced pressure appliance 29 for enclosing a tissue site to provide a fluid-tight or gas-tight enclosure over the tissue site to grow tissue 24 in a tissue growth medium 10 through the application of sub-atmospheric pressure. The directed tissue growth apparatus 25 includes a reduced pressure appliance, generally designated 29, which is applied to and sealed over a tissue site in order to enclose the tissue site to form a reduced pressure chamber about the tissue site for treatment with suction or reduced pressure within a sealed generally fluid-tight or gas-tight enclosure. For the purpose of creating suction within the appliance 29, the appliance 29 is connected with a vacuum system, generally designated 30, to provide a source of suction or reduced pressure for the sealed appliance 29 at the tissue site. The vacuum system 30 may include a suction device 31 and an optional fluid collection device 32 intermediate the hose 12 and suction device 31. The fluid collection device 32 functions to collect any exudate that may be aspirated from the tissue. A stop mechanism 33 may be provided to halt application of the suction device 31 upon collection of a predetermined quantity of fluid in the fluid collection device 32. The appliance 29 includes a fluid-impermeable tissue cover 18 in the form of a flexible, adhesive, fluid impermeable polymer sheet for covering and enclosing the tissue 24 at the tissue site. The tissue cover 18 includes an adhesive backing 20 which functions to seal the tissue cover about the periphery of the tissue 24 to provide a generally gas-tight or fluid-tight enclosure over the tissue 24. The adhesive cover sheet 18 must have sufficient adhesion to form a fluid-tight or gas-tight seal 19 around the tissue 24 and to hold the sheet 18 in sealed contact at the attachment site during the application of suction or reduced pressure. Alternatively, the cover 18 may be provided in the form of a rigid or semi-rigid cover adapted to form a fluid-tight or gas-tight seal around the tissue. Suitable modifications may be made to the appliance to provide a reduced pressure chamber for treating the selected tissue.
  • The [0023] appliance 29 also includes a porous tissue growth medium 10 which is positioned under the cover 18 on or in the tissue 24. The tissue growth medium 10 is disposed over a sufficient expanse of the tissue 24 to promote sufficient growth of new tissue cells within the tissue growth medium 10. The tissue growth medium 10 should be sufficiently porous to allow for connection to a vacuum system 30 to supply sub-atmospheric pressure to the tissue 24 and the tissue growth medium 10. The tissue growth medium 10 may also be perforated to enhance gas flow and to reduce the weight of the appliance. The configuration and composition of the tissue growth medium 10 can be adjusted to suit the particular tissue type. For example, for growth in bone tissue, the tissue growth medium 10 may comprise a natural, synthetic, or natural-synthetic hybrid porous material. Such a tissue growth medium 10 may conveniently be chosen to provide a scaffold to support or direct osteoconduction, i.e. bone formation. Alternatively or additionally, such a tissue growth medium 10 may be selected from materials which induce differentiation of stem cells to osteogenic cells, i.e. osteoinductive agents, or materials which provide stem cells, e.g. bone marrow aspirate.
  • For example, a [0024] tissue growth medium 10 for use in bone growth may be a bioglass, ceramic material, or other natural or synthetic porous material. In particular, materials comprising calcium sulphate or calcium phosphate are suited for use as a bone tissue growth medium 10. A calcium sulfate bone substitute is completely absorbed by osteoclasts, and osteoblasts will attach to the calcium sulfate bone substitute and lay osteoid on it. The process of absorption by osteoclasts is complete and quick. Hence, it can be used with antibiotics in presence of infection. A chief advantage is that a calcium sulfate bone substitute can be used in presence of infection as well as being one of the least expensive bone substitutes. Calcium sulphate bone substitutes principally possess osteoconductive properties and no osteoinductive properties, though such a material could be modified to provide osteoinductive properties. One suitable calcium sulphate bone substitute is OSTEOSET® Bone Graft Substitute, a product of Wright Medical Technology, Inc. of Arlington Tenn.
  • Another class of suitable materials is one comprising various derivates of calcium phosphate, which can be used to provide a structural matrix for osteoconduction. These derivatives also do not possess any osteoinductive properties. The commonly used derivates are: hydroxyapatite (coral based or chemically derived synthetic ceramic), fluorapatite, tri-calcium phosphate, bioglass ceramics and combinations thereof. One suitable calcium phosphate bone substitute is OsteoGraft™ Bone Graft Substitute, a product of Millenium Biologix of Kingston, Ontario, Canada. [0025]
  • The [0026] appliance 29 also includes a suction port in the form of a hollow suction tube 12 that connects either directly or indirectly with the vacuum system 30 to provide suction within the sealed enclosure. The outlet of suction tubing 12 serves as a suction port for the appliance 29. An end segment 12 a of the tubing 12 is embedded within the tissue growth medium 10 for providing suction or reduced pressure within the chamber provided under the tissue cover 18. The open-cell structure of the tissue growth medium 10 also permits the tissue growth medium 10 to distribute the reduced pressure within the chamber. Embedding the open end of segment 12 a of tubing 12 within the interior of the tissue growth medium 10 permits the tissue growth medium 10 to function as a shield to help prevent the tissue cover 18 from being inadvertently sucked into occlusive engagement with the open end of the tube thereby plugging the tube 12 and restricting gas flow. The open-cell structure of the tissue growth medium 10 also permits the tissue growth medium 10 to distribute the reduced pressure within the sealed enclosure.
  • The [0027] tube segment 12 a embedded within the tissue growth medium 10 optionally has at least one side port 14 for positioning within the interior of the tissue growth medium 10 to promote substantially uniform application of reduced pressure throughout the enclosure. Positioning the side port 14 of tube segment 12 a within the interior of the tissue growth medium 10 permits the tissue growth medium 10 to also function as a shield for the side port to thereby prevent the tissue cover 18 from being sucked into the side port 14 and thereby restricting gas flow. The open cells of the tissue growth medium 10 facilitate growth of tissue therein and facilitate gas flow throughout the enclosure. In addition, the tissue growth medium 10 functions to hold the tissue cover 18 generally out of contact with the tissue 24 during the application of suction within the enclosure.
  • [0028] Tubing 12 and tube segment 12 a may be sufficiently flexible to permit movement of the tubing but are sufficiently rigid to resist constriction when reduced pressure is supplied to the appliance 29 or when the location of the tissue is such that the patient must sit or lie upon the tubing 12 or upon the reduced pressure appliance 29. The assembly comprising the tissue growth medium 10 and the tube 12 may be fabricated by snaking the end of the tube segment 12 a through an internal passageway in the tissue growth medium 10 such as by pulling the end of the tube segment 12 a through the passageway using forceps. The assembly is preferably prepared prior to use under sterile conditions and then stored in an aseptic package.
  • In order to use the reduced [0029] pressure appliance 29 at the site of the tissue 24, the flexible, fluid-impermeable, adhesive tissue cover sheet 18 is secured in position at the tissue site, overlying the tissue growth medium 10 disposed in contact with the tissue 24. The tissue cover sheet 18 is secured and sealed to the attachment site 22 by an adhesive layer 20 on the under surface of the tissue cover 18 to form a gas-tight seal 19 about the tissue 24. The tissue cover 18 also provides a gas-tight seal around the tubing 12 at the feedthrough location 22 a where the tubing 12 emerges from beneath the tissue cover 18. The tissue cover 18 is preferably formed of a fluid impermeable or gas impermeable flexible adhesive sheet such as Ioban, a product of the 3M Corporation of Minneapolis, Minn.
  • Predetermined amounts of suction or reduced pressure may be produced by the [0030] vacuum system 30. The vacuum system 30 is preferably controlled by a control device or control circuitry that includes a switch or a timer which may be set to provide cyclic on/off operation of the vacuum system 30 according to user-selected intervals. Alternatively, the vacuum system 30 may be operated continuously without the use of a cyclical timer. The control may also include a pressure selector to enable the amount of suction produced by the system to be adjusted so that a suitable sub-atmospheric pressure may be created within the chamber. Operation of the vacuum system 30 may be controlled to permit graduated increases in the amount of vacuum applied or graduated decreases in the amount of vacuum applied.
  • Referring to FIG. 2, an alternative configuration of the reduced pressure appliance [0031] 129 is shown which is similar to the reduced pressure appliance 29 of FIG. 1. The elements of the appliance 129 of FIG. 2 which are similar to like elements depicted in FIG. 1 utilize the same reference number as used in FIG. 1 but with a 100-series added to such reference numerals. A principal difference between the reduced pressure appliance 129 of FIG. 2 and that of FIG. 1 is that a porous open-cell foam section 111 is provided for communication with the vacuum system 130. The open-cell foam section 111 in turn communicates with the tissue growth medium 110, which may or may not be porous.
  • The directed [0032] tissue growth apparatus 125 includes a reduced pressure appliance, generally designated 129, which is applied to and sealed over a tissue site in order to enclose the tissue site for treatment with suction or reduced pressure within a sealed generally fluid-tight or gas-tight enclosure. For the purpose of creating suction within the appliance 129, the appliance 129 is connected with a vacuum system, generally designated 130, to provide a source of suction or reduced pressure for the sealed appliance 129 at the tissue site. The appliance 129 includes a fluid-impermeable tissue cover 118 in the form of a flexible, fluid impermeable polymer sheet for covering and enclosing the tissue 124 at the tissue site. The tissue cover 118 may include an adhesive backing 120 at least around the periphery of the cover which functions to seal the tissue cover proximate to the tissue 124 to provide a generally gas-tight or fluid-tight enclosure over the tissue 124. The adhesive cover sheet 118 must have sufficient adhesion to form a fluid-tight or gas-tight seal 119 around the tissue 124 and to hold the sheet 118 in sealed contact with the attachment site around the tissue 124 during the application of suction or reduced pressure. The cover 118 may also be provided in the form of a rigid or semi-rigid cover which cooperates with a suitable seal to form a fluid-tight or gas-tight seal around the tissue.
  • The appliance [0033] 129 also includes a porous open-cell foam section 111 which is placed under the cover 118 and in direct or indirect contact with a tissue growth medium 110. The open-cell foam section 111 should be sufficiently porous to allow for connection to the vacuum system 130 to transmit sub-atmospheric pressure to the tissue 124 and the tissue growth medium 110. The tissue growth medium 110 is placed over a sufficient expanse of the tissue 124 to promote sufficient growth of new tissue cells within the tissue growth medium 110. The tissue growth medium 110 and/or the foam section 111 may also be perforated or channeled to enhance gas flow and to reduce the weight of the appliance. The configuration depicted in FIG. 2 is particularly suitable for use with non-porous growth media or a relatively thin growth medium, such as a skin substitute material. A skin substitute material may comprise a multilayer structure having, for example, a layer of collagen for contact with the tissue to be grown and a silicone layer disposed on top of the collagen layer for contact with the foam section 111. A suitable skin substitute material is INTEGRA® Dermal Regeneration Template, a product of Integra LifeSciences Corp. of Plainsboro, N.J. The silicone layer provides a removable backing to support the collagen layer during tissue ingrowth. After growth has continued to a desired stage, the silicone layer may be removed from the collagen layer, leaving the neodermis in place, onto which a thin split thickness skin graft may be placed.
  • For another application, the [0034] growth medium 110 can be formed for the purpose of growing an organ, such as the pancreas or liver. The growth medium 110 may take the form of a scaffold/matrix of either a naturally occurring molecule (e.g., collagen) or of resorbable materials (e.g., polyglycolic acid or polygalactic acid or a combination thereof). The growth medium 110 may be formed from commercially available screens which are layered to the desired thickness.
  • The appliance [0035] 129 also includes a suction port in the form of a hollow suction tube 112, similar to the tube 12 of FIG. 1, that connects with the vacuum system 130 to provide suction within the sealed enclosure. The suction tubing 112 provides at least one suction port for the appliance 129. Unlike the device of FIG. 1, an end segment 112 a of the tubing 112 is embedded within the foam section 111, rather than in the tissue growth material, for providing suction or reduced pressure within the enclosure provided under the tissue cover 118. The open-cell structure of the foam section 111 permits the foam section 111 to distribute the reduced pressure within the enclosure. Embedding the open end of segment 112 a of tubing 112 within the interior of the foam section 111 permits the foam section 111 to function as a shield to help prevent the tissue cover 118 from being inadvertently sucked into the open end of the tube thereby plugging the tube 112 and restricting gas flow. The open-cell structure of the foam section 111 also permits the foam section 111 to distribute the pressure within the sealed enclosure.
  • The [0036] tube segment 112 a embedded within the foam section 111 preferably has at least one side port 114 for positioning within the interior of the foam section 111 to promote substantially uniform application of reduced pressure throughout the enclosure. Positioning the side port 114 of tube segment 112 a within the interior of the foam section 111 permits the foam section 111 to function as a shield for the side port to thereby prevent the tissue cover 118 from being sucked into the side port 114 and thereby restricting gas flow. The open cells of the foam section 111 facilitate gas flow throughout the enclosure. In addition, the foam section 111 functions to hold the tissue cover 118 generally out of contact with the tissue 124 during the application of suction within the enclosure.
  • Similar to the [0037] appliance 29 of FIG. 1, the flexible, fluid-impermeable, adhesive tissue cover sheet 118 of appliance 129 is secured, during use, in position at the tissue site, overlying the foam section 111 and tissue growth medium 110 which contacts the tissue 124. The tissue cover sheet 118 is secured and sealed to the attachment site 122 by an adhesive layer 120 on the under surface of the tissue cover 118 to form a gas-tight seal 119 about the tissue 124. The tissue cover 118 also provides a gas-tight seal around the tubing 112 at the feedthrough location 122 a where the tubing 112 emerges from beneath the tissue cover 118.
  • Reduced pressure appliances are useful for growing a variety of tissues. Directed growth of a tissue can be carried out by securing a reduced pressure appliance to the treatment site as previously shown and described, and then maintaining a substantially continuous or cyclical reduced pressure within the appliance until the newly grown tissue has reached a desired degree of development. The method may be practiced using a subatmospheric pressure ranging from about 0.5 to about 0.98 atmospheres, and more specifically about 0.73 atmospheres to about 0.95 atmospheres, and more preferably practiced using a subatmospheric pressure ranging between about 0.8 to about 0.9 atmospheres. The time period for use of the method on a tissue may preferably be at least 48 hours, but can, for example, be extended for multiple days. Satisfactory growth of various types of tissues has been obtained via the use of reduced pressures equivalent to about 1 to 8 in. Hg below atmospheric pressure. [0038]
  • Supplying reduced pressure to the appliance in an intermittent or cyclic manner may be desirable for growing tissues. Intermittent or cyclic supply of reduced pressure to an appliance may be achieved by manual or automatic control of the vacuum system. A cycle ratio, the ratio of “on” time to “off” time, in such an intermittent reduced pressure treatment may be as low as 1:10 or as high as 10:1. The preferred ratio is approximately 5 minutes on which is usually accomplished in alternating intervals of 5 minutes of reduced pressure supply and 2 minutes of non-supply. [0039]
  • A suitable vacuum system includes any suction pump capable of providing at least 5 mm of Hg of suction to the tissue, and preferably up to 125 mm of Hg suction, and most preferably up to approximately 200 mm of Hg of suction or even higher as necessary to achieve subatmospheric pressures of about 0.5 atmospheres. The pump can be any ordinary suction pump suitable for medical purposes that is capable of providing the necessary suction. The dimension of the tubing interconnecting the pump and the reduced pressure appliance is controlled by the pump's ability to provide the suction level needed for operation. For example, a ¼ inch diameter tube may be suitable. [0040]
  • The present invention also includes a method of growing tissue which comprises the steps of applying reduced pressure to a tissue for a selected time and at a selected magnitude sufficient to promote cell growth in a matrix or scaffold material. Further features of the apparatus and method for use thereof shall be made apparent in the following example. [0041]
  • EXAMPLE 1
  • This example was designed to demonstrate the effectiveness of the method of the invention for accelerating the rate of vascular ingrowth in a skin substitute material. [0042]
  • Several 25 kg pigs were sedated and prepped for surgery. A series of 2 cm by 5 cm full thickness defects (down to the deep back muscles) were created on each side of the back of the animal. A directed tissue growth apparatus of the type shown in FIG. 2 comprising INTEGRA® Dermal Regeneration Template was applied to the wound site on one side of each animal. An INTEGRA® Dermal Regeneration Template was applied to the wound site on the other side of each animal. The INTEGRA® Dermal Regeneration Template was applied according the manufacturer's directions. Vacuum (125 mm Hg, continuous) was applied to the directed tissue growth apparatus positioned on the selected wound sites on one side of the pigs. After 72 hours, the apparatus was removed, and the pieces of INTEGRA® Dermal Regeneration Template were peeled off from the vacuum-treated and non-vacuum-treated wound sites at 10 cm/sec. The force required to pull the pieces off was recorded. A paired T-test was used to determine statistical significance of the pull force data. [0043]
  • The INTEGRA® Dermal Regeneration Template at the non-vacuum-treated wound site required a force of 1.25×10[0044] 5+/−0.51×105 dynes to separate the template from the wound site. The INTEGRA® Dermal Regeneration Template at the vacuum-treated wound site required a greater force of 2.25×105+/−0.51×105 dynes to separate the vacuum-treated template from the wound site. The increased pull force required at the vacuum-treated wound site indicated increased ingrowth of vasculature in the skin substitute material due to the vacuum treatment. The increased vascular ingrowth was confirmed by micrographs of the vacuum-treated and non-vacuum-treated pieces of INTEGRA® Dermal Regeneration Template removed from the animals.
  • The terms and expressions which have been employed are used as terms of description and not of limitation and there is no intention in the use of such terms and expressions of excluding any equivalents of the features shown and described, or portions thereof, but it is recognized that various modifications are possible within the scope of the claimed invention. [0045]

Claims (114)

What is claimed is:
1. An appliance for administering a reduced pressure treatment to promote directed growth of a tissue comprising:
(a) a cover adapted to cover and enclose a tissue to be grown and adapted to maintain reduced pressure at the site of the tissue;
(b) a seal adapted to seal the cover about the tissue;
(c) reduced pressure supply means for connection to a source of suction, the reduced pressure supply means cooperating with the cover to supply the reduced pressure beneath the cover; and
(d) a bone substitute material adapted to promote tissue growth therein, the bone substitute material being located between the tissue and the cover.
2. An appliance according to claim 1 wherein the bone substitute material comprises a bioabsorbable material.
3. An appliance according to claim 1 wherein the bone substitute material comprises at least one of calcium sulfate, calcium phosphate, a bioglass, or a ceramic.
4. An appliance according to claim 1 wherein the cover comprises a flexible sheet.
5. An appliance according to claim 1 wherein the bone substitute material comprises a porous material.
6. An appliance according to claim 1 wherein the seal includes an adhesive material on the cover adapted to secure the cover to the tissue to be grown.
7. An appliance according to claim 1 wherein the reduced pressure supply means includes a segment of tubing embedded within the bone substitute material.
8. An apparatus for growing a tissue, comprising:
vacuum means for creating a sub-atmospheric pressure at a tissue to be grown;
sealing means operatively associated with the vacuum means for maintaining the sub-atmospheric pressure at the tissue by contacting the region surrounding the tissue; and
a bone substitute material for positioning at the tissue within the sealing means and adapted to promote tissue growth therein.
9. An apparatus according to claim 8 wherein the bone substitute material comprises a bioabsorbable material.
10. An apparatus according to claim 8 wherein the bone substitute material comprises at least one of calcium sulfate, calcium phosphate, a bioglass, or a ceramic.
11. An apparatus according to claim 8, wherein the sealing means includes a flexible sealing rim in contact with the region surrounding the tissue.
12. An apparatus according to claim 8, wherein the sealing means includes a flexible polymer sheet overlying the bone substitute material, the polymer sheet having adhesive on at least a surface facing the tissue to attach and seal the polymer sheet to the region surrounding the tissue.
13. An apparatus according to claim 8, wherein the sealing means comprises a fluid-impermeable cover.
14. An apparatus according to claim 8 wherein the vacuum means supplies a sub-atmospheric pressure between about 0.5 and 0.98 atmospheres to the tissue.
15. An apparatus according to claim 8 wherein the vacuum means supplies a sub-atmospheric pressure between about 0.73 and 0.95 atmospheres to the tissue.
16. An apparatus according to claim 8 wherein the vacuum means supplies a sub-atmospheric pressure between about 0.8 and 0.9 atmospheres to the tissue.
17. An apparatus according to claim 8, wherein the vacuum means operates continuously.
18. An apparatus according to claim 8, wherein the vacuum means operates cyclically to provide periods of application and non-application of suction.
19. An apparatus according to claim 18 wherein the vacuum means provides periods of application and non-application of suction with the ratio of duration of application period to non-application period between about 1:10 and 10:1.
20. An apparatus according to claim 19 wherein the duration of the application period is about 5 minutes.
21. An apparatus according to claim 20 wherein the duration of the non-application period is about 2 minutes.
22. An apparatus for applying sub-atmospheric pressure to a tissue to be grown beneath a fluid-impermeable seal comprising:
a bone substitute material for positioning beneath the seal configured to overlie the tissue such that the sub-atmospheric pressure is maintained within the bone substitute material and is applied to the tissue; and
a flexible tube having an inlet end inserted into the bone substitute material and an outlet end for extending from beneath the seal for supplying the sub-atmospheric pressure.
23. An apparatus according to claim 22 wherein the bone substitute material comprises a bioabsorbable material.
24. An apparatus according to claim 22 wherein the bone substitute material comprises at least one of calcium sulfate, calcium phosphate, a bioglass, or a ceramic.
25. An apparatus for growing a tissue, comprising:
a bone substitute material configured to overlie a tissue to be grown;
a fluid-impermeable cover overlying the bone substitute material, the cover adapted to form a seal with the region surrounding the tissue for maintaining sub-atmospheric pressure beneath the cover; and
a tubular member having a first end inserted within a portion of the bone substitute material and having a second end extending from beneath the cover to a location external to the cover for supplying sub-atmospheric pressure beneath the cover.
26. An apparatus according to claim 25 wherein the bone substitute material comprises a bioabsorbable material.
27. An apparatus according to claim 25 wherein the bone substitute material comprises at least one of calcium sulfate, calcium phosphate, a bioglass, or a ceramic.
28. An apparatus according to claim 25 wherein the first end of the tubular member is embedded within the bone substitute material.
29. An apparatus for growing a tissue, comprising:
vacuum means for creating a sub-atmospheric pressure at a tissue to be grown;
sealing means operatively associated with the vacuum means for maintaining the sub-atmospheric pressure at the tissue by contacting the region surrounding the tissue; and
a bone substitute material for positioning at the tissue within the sealing means, the bone substitute material having a pore size sufficiently large to permit tissue growth therein.
30. An apparatus according to claim 29, wherein the bone substitute material comprises a bioabsorbable material.
31. An apparatus according to claim 29, wherein the bone substitute material comprises at least one of calcium sulfate, calcium phosphate, a bioglass, or a ceramic.
32. An apparatus according to claim 29, wherein the sealing means includes a flexible sealing rim in contact with the region surrounding the tissue.
33. An apparatus according to claim 29, wherein the sealing means includes a flexible polymer sheet overlying the bone substitute material, the polymer sheet having adhesive on at least a surface facing the tissue to attach and seal the polymer sheet to the region surrounding the tissue.
34. An apparatus according to claim 29, wherein the vacuum means operates continuously.
35. An apparatus according to claim 29, wherein the vacuum means operates cyclically to provide periods of application and non-application of suction.
36. An apparatus according to claim 35, wherein the vacuum means operates cyclically to provide periods of application and non-application of suction with the ratio of duration of application period to non-application period between about 1:10 and 10:1.
37. An apparatus according to claim 36 wherein the duration of the application period is about 5 minutes.
38. An apparatus according to claim 37 wherein the duration of the non-application period is about 2 minutes.
39. An apparatus for growing a tissue comprising:
a bone substitute material configured to overlie the tissue;
a cover overlying the bone substitute material, the cover adapted to form a seal with the region surrounding the tissue for maintaining a sub-atmospheric pressure beneath the cover;
a tubular member having a first end inserted within a portion of the bone substitute material and having a second end extending from beneath the cover to a location external to the cover; and
a vacuum source connected with the second end of the tubular member for supplying the sub-atmospheric pressure to the tissue.
40. An apparatus according to claim 39 wherein the bone substitute material comprises a bioabsorbable material.
41. An apparatus according to claim 39 wherein the bone substitute material comprises at least one of calcium sulfate, calcium phosphate, a bioglass, or a ceramic.
42. An apparatus according to claim 39 wherein the vacuum source supplies a sub-atmospheric pressure between about 0.5 and 0.98 atmospheres to the tissue.
43. An apparatus according to claim 39 wherein the vacuum source supplies a sub-atmospheric pressure between about 0.73 and 0.95 atmospheres to the tissue.
44. An apparatus according to claim 39 wherein the vacuum source supplies a sub-atmospheric pressure between about 0.8 and 0.9 atmospheres to the tissue.
45. An apparatus according to claim 39 wherein the first end of the tubular member is embedded within the bone substitute material.
46. An apparatus for growing a tissue comprising:
a bioabsorbable scaffold material configured to overlie the tissue, the scaffold material having a pore size sufficiently large to permit tissue growth therein;
an open-cell foam section in communication with the scaffold material;
a cover overlying the scaffold material and the foam section, the cover adapted to form a seal with the region surrounding the tissue for maintaining a sub-atmospheric pressure beneath the cover; and
a tubular member having a first end inserted within a portion of the foam section and having a second end extending from beneath the cover to a location external to the cover for supplying the sub-atmospheric pressure beneath the cover.
47. An apparatus according to claim 46 wherein the scaffold material comprises a skin substitute material.
48. An apparatus according to claim 46 wherein the scaffold material comprises a collagen layer.
49. An appliance for administering a reduced pressure treatment to promote directed growth of a tissue comprising:
(a) a cover adapted to cover and enclose a tissue to be grown and adapted to maintain reduced pressure at the site of the tissue;
(b) a seal adapted to seal the cover about the tissue;
(c) reduced pressure supply means for connection to a source of suction, the reduced pressure supply means cooperating with the cover to supply the reduced pressure beneath the cover; and
(d) a bioabsorbable scaffold material for promoting tissue growth therein configured to be located between the tissue and the cover.
50. An appliance according to claim 49 wherein the scaffold material comprises a skin substitute material.
51. An appliance according to claim 49 wherein the scaffold material comprises a collagen layer.
52. An appliance according to claim 49 wherein the cover comprises a flexible sheet.
53. An appliance according to claim 49 wherein the seal includes an adhesive material on the cover adapted to secure the cover to the tissue to be grown.
54. An appliance according to claim 49 comprising an open-cell foam section in communication with the scaffold material.
55. An appliance according in claim 54 wherein the reduced pressure supply means includes a segment of tubing embedded within the foam section.
56. An apparatus for growing a tissue, comprising:
vacuum means for creating a sub-atmospheric pressure at a tissue to be grown;
sealing means operatively associated with the vacuum means for maintaining the sub-atmospheric pressure at the tissue by contacting the region surrounding the tissue; and
a bioabsorbable scaffold material for positioning at the tissue within the sealing means and adapted to promote tissue growth therein.
57. An apparatus according to claim 56 wherein the scaffold material comprises a skin substitute material.
58. An apparatus according to claim 56 wherein the scaffold material comprises a collagen layer.
59. An apparatus according to claim 56, wherein the sealing means includes a flexible sealing rim in contact with the region surrounding the tissue.
60. An apparatus according to claim 56, wherein the sealing means comprises a fluid-impermeable cover.
61. An apparatus according to claim 56, wherein the sealing means includes a flexible polymer sheet overlying the scaffold material, the polymer sheet having adhesive on at least a surface facing the tissue to attach and seal the polymer sheet to the region surrounding the tissue.
62. An apparatus according to claim 56 comprising an open-cell foam section in communication with the scaffold material.
63. An apparatus according to claim 62 wherein the vacuum means includes a segment of tubing embedded within the foam section.
64. An apparatus according to claim 56, wherein the vacuum means operates continuously.
65. An apparatus according to claim 56, wherein the vacuum means operates cyclically to provide periods of application and non-application of suction.
66. An apparatus according to claim 65 wherein the vacuum means provides periods of application and non-application of suction with the ratio of duration of application period to non-application period between about 1:10 and 10:1.
67. An apparatus according to claim 66 wherein the duration of the application period is about 5 minutes.
68. An apparatus according to claim 67 wherein the duration of the non-application period is about 2 minutes.
69. An apparatus according to claim 56 wherein the vacuum means supplies a sub-atmospheric pressure between about 0.5 and 0.98 atmospheres to the tissue.
70. An apparatus according to claim 56 wherein the vacuum means supplies a sub-atmospheric pressure between about 0.73 and 0.95 atmospheres to the tissue.
71. An apparatus according to claim 56 wherein the vacuum means supplies a sub-atmospheric pressure between about 0.8 and 0.9 atmospheres to the tissue.
72. An apparatus for applying sub-atmospheric pressure to a tissue to be grown beneath a fluid-impermeable seal comprising:
a bioabsorbable scaffold material for positioning beneath the seal configured to overlie the tissue; and
a flexible tube having an inlet end inserted into the scaffold material and an outlet end for extending from beneath the seal for supplying a sub-atmospheric pressure to the tissue.
73. An apparatus according to claim 72 wherein the scaffold material has a pore size sufficiently large to permit tissue growth therein.
74. An apparatus according to claim 72 wherein the scaffold material comprises a skin substitute material.
75. An apparatus according to claim 72 wherein the scaffold material comprises collagen.
76. An apparatus for growing a tissue, comprising:
a bioabsorbable scaffold material configured to overlie a tissue to be grown;
an open-cell foam section in communication with the scaffold material;
a fluid-impermeable cover overlying the scaffold material and the foam section, the cover adapted to form a seal with the region surrounding the tissue for maintaining sub-atmospheric pressure beneath the cover; and
a tubular member having a first end inserted within a portion of the foam section and having a second end extending from beneath the cover to a location external to the cover for supplying sub-atmospheric pressure beneath the cover.
77. An apparatus according to claim 76 wherein the scaffold material comprises a skin substitute material.
78. An apparatus according to claim 77 wherein the scaffold material comprises a collagen layer.
79. An apparatus for growing a tissue, comprising:
vacuum means for creating a sub-atmospheric pressure at a tissue to be grown;
sealing means operatively associated with the vacuum means for maintaining the sub-atmospheric pressure at the tissue by contacting the region surrounding the tissue; and
a bioabsorbable scaffold material for positioning at the tissue within the sealing means, the scaffold material having a pore size sufficiently large to permit tissue growth therein.
80. An apparatus according to claim 79, wherein the scaffold material comprises a skin substitute material.
81. An apparatus according to claim 79, wherein the scaffold material comprises collagen.
82. An apparatus according to claim 79, wherein the sealing means includes a flexible sealing rim in contact with the region surrounding the tissue.
83. An apparatus according to claim 79, wherein the cover includes a flexible polymer sheet overlying the scaffold material, the polymer sheet having adhesive on at least a surface facing the tissue to attach and seal the polymer sheet to the region surrounding the tissue.
84. An apparatus according to claim 79 wherein the vacuum means includes a segment of tubing embedded within the scaffold material.
85. An apparatus according to claim 79, wherein the vacuum means operates continuously.
86. An apparatus according to claim 79, wherein the vacuum means operates cyclically to provide periods of application and non-application of suction.
87. An apparatus according to claim 86, wherein the vacuum means operates cyclically to provide periods of application and non-application of suction with the ratio of duration of application period to non-application period between about 1:10 and 10:1.
88. An apparatus according to claim 87 wherein the duration of the application period is about 5 minutes.
89. An apparatus according to claim 88 wherein the duration of the non-application period is about 2 minutes.
90. An apparatus for growing a tissue comprising:
a bioabsorbable scaffold material configured to overlie the tissue;
a cover overlying the scaffold material, the cover adapted to form a seal with the region surrounding the tissue for maintaining a sub-atmospheric pressure beneath the cover;
a tubular member having a first end inserted within a portion of the scaffold material and having a second end extending from beneath the cover to a location external to the cover; and
a vacuum source connected with the second end of the tubular member for supplying the sub-atmospheric pressure to the tissue.
91. An apparatus according to claim 90 wherein the scaffold material comprises a skin substitute material.
92. An apparatus according to claim 90 wherein the scaffold material comprises a collagen layer.
93. An apparatus according to claim 90 wherein the vacuum source supplies a sub-atmospheric pressure between about 0.5 and 0.98 atmospheres to the tissue.
94. An apparatus according to claim 90 wherein the vacuum source supplies a sub-atmospheric pressure between about 0.73 and 0.95 atmospheres to the tissue.
95. An apparatus according to claim 90 wherein the vacuum source supplies a sub-atmospheric pressure between about 0.8 and 0.9 atmospheres to the tissue.
96. A method of growing a tissue comprising the steps of:
(a) providing a tissue growth medium proximate the tissue;
(b) applying a sub-atmospheric pressure to a tissue to be grown; and
(c) maintaining the sub-atmospheric pressure until the tissue has progressed toward a selected stage of growth within the tissue growth medium.
97. The method according to claim 96, wherein the maintaining of the sub-atmospheric pressure is conducted in alternating periods of application and non-application of the sub-atmospheric pressure.
98. The method according to claim 97, wherein each of the alternating periods is about 5 minutes.
99. The method according to claim 96, wherein the tissue growth medium comprises a bioabsorbable scaffold material.
100. The method according to claim 99, wherein the scaffold material comprises a skin substitute material.
101. The method according to claim 99, wherein the scaffold material comprises a collagen layer.
102. The method according to claim 96, wherein the tissue growth medium comprises a bone substitute material.
103. The method according to claim 102, wherein the bone substitute material comprises a bioabsorbable material.
104. The method according to claim 102, wherein the bone substitute material comprises at least one of calcium sulfate, calcium phosphate, a bioglass, or a ceramic.
105. A method for growing a tissue comprising the steps of:
(a) applying a sub-atmospheric pressure to a tissue to be grown, wherein the applying step comprises the steps of:
(i) placing a tissue growth medium in contact with a tissue to be grown;
(ii) locating a cover over the tissue;
(iii) sealing the periphery of the cover about the tissue; and
(iv) operably connecting the cover with a vacuum system for producing the sub-atmospheric pressure; and
(b) maintaining the sub-atmospheric pressure until the tissue has progressed toward a selected stage of growth within the tissue growth medium.
106. The method according to claim 105, wherein the maintaining of the sub-atmospheric pressure is conducted in alternating periods of application and non-application of the sub-atmospheric pressure.
107. The method according to claim 106, wherein each of the alternating periods is about 5 minutes.
108. The method according to claim 105, wherein the tissue growth medium comprises a bioabsorbable scaffold material.
109. The method according to claim 108, wherein the scaffold material comprises a skin substitute material.
110. The method according to claim 108, wherein the scaffold material comprises a collagen layer.
111. The method according to claim 105, wherein the tissue growth medium comprises a bone substitute material.
112. The method according to claim 111, wherein the bone substitute material comprises a bioabsorbable material.
113. The method according to claim 111, wherein the bone substitute material comprises at least one of calcium sulfate, calcium phosphate, a bioglass, or a ceramic.
114. A method for growing new bone tissue from existing bone tissue comprising the steps of:
(a) placing a bone substitute material in contact with the existing bone tissue to provide a matrix in which to grow new bone tissue;
(b) locating a cover over the existing bone tissue and the bone substitute material to form a sealed chamber at the bone tissue and the bone substitute material;
(c) providing a subatmospheric pressure within the chamber; and
(d) maintaining the sub-atmospheric pressure within the chamber until new bone tissue of a desired amount is grown within the bone substitute material.
US10/161,076 2002-06-03 2002-06-03 Directed tissue growth employing reduced pressure Abandoned US20030225347A1 (en)

Priority Applications (26)

Application Number Priority Date Filing Date Title
US10/161,076 US20030225347A1 (en) 2002-06-03 2002-06-03 Directed tissue growth employing reduced pressure
BR0311584-4A BR0311584A (en) 2002-06-03 2003-05-28 A tool for administering reduced pressure treatment to promote directed tissue growth, tissue growth apparatus, apparatus for applying sub-atmospheric pressure to a tissue to be grown under a fluid impermeable seal, method of growing a tissue, and, Method to grow new bone tissue from existing bone tissue
AT03756228T ATE521317T1 (en) 2002-06-03 2003-05-28 TARGETED TISSUE GROWTH WITH REDUCED PRESSURE
DK11175725.8T DK2392302T3 (en) 2002-06-03 2003-05-28 Conducted tissue culture using reduced pressure
CN2013100124298A CN103142337A (en) 2002-06-03 2003-05-28 Directed tissue growth employing reduced pressure
AU2003231870A AU2003231870B2 (en) 2002-06-03 2003-05-28 Directed tissue growth employing reduced pressure
JP2004508743A JP4467428B2 (en) 2002-06-03 2003-05-28 Directed tissue growth using reduced pressure
ES11175725T ES2402238T3 (en) 2002-06-03 2003-05-28 Targeted tissue growth using reduced pressure
KR1020047019708A KR101007625B1 (en) 2002-06-03 2003-05-28 Directed tissue growth employing reduced pressure
EP11175725A EP2392302B1 (en) 2002-06-03 2003-05-28 Directed tissue growth employing reduced pressure
MXPA04012141A MXPA04012141A (en) 2002-06-03 2003-05-28 Directed tissue growth employing reduced pressure.
ES03756228T ES2370817T3 (en) 2002-06-03 2003-05-28 DIRECTED FABRIC CULTURE EMPLENATED REDUCED PRESSURE.
CA2490027A CA2490027C (en) 2002-06-03 2003-05-28 Directed tissue growth employing reduced pressure
CNB038181703A CN100339061C (en) 2002-06-03 2003-05-28 Directed tissue growth employing reduced pressure
DK03756228.7T DK1517660T3 (en) 2002-06-03 2003-05-28 Directed tissue culture using reduced pressure
CN2007101487397A CN101143120B (en) 2002-06-03 2003-05-28 Directed tissue growth employing reduced pressure
PCT/US2003/016763 WO2003101385A2 (en) 2002-06-03 2003-05-28 Directed tissue growth employing reduced pressure
EP03756228A EP1517660B1 (en) 2002-06-03 2003-05-28 Directed tissue growth employing reduced pressure
ZA2004/09274A ZA200409274B (en) 2002-06-03 2004-11-18 Directed tissue growth employing reduced pressure
IL165508A IL165508A (en) 2002-06-03 2004-12-02 Directed tissue growth employing reduced pressure
HK05108562.6A HK1076594A1 (en) 2002-06-03 2005-09-28 Directed tissue growth employing reduced pressure
HK06103432A HK1083441A1 (en) 2002-06-03 2006-03-17 Directed tissue growth employing reduced pressure
HK08110409.6A HK1119043A1 (en) 2002-06-03 2008-09-19 Directed tissue growth employing reduced pressure
AU2009201422A AU2009201422B2 (en) 2002-06-03 2009-04-08 Directed tissue growth employing reduced pressure
JP2009188084A JP5280969B2 (en) 2002-06-03 2009-08-14 Directed tissue growth using reduced pressure
HK12101118.1A HK1160754A1 (en) 2002-06-03 2012-02-06 Directed tissue growth employing reduced pressure

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Cited By (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030108587A1 (en) * 2001-05-15 2003-06-12 Orgill Dennis P. Methods and apparatus for application of micro-mechanical forces to tissues
US20050070835A1 (en) * 2003-09-08 2005-03-31 Joshi Ashok V. Device and method for wound therapy
US7169151B1 (en) 2003-04-10 2007-01-30 Kci Licensing, Inc. Bone regeneration device for long bones, and method of use
US20070066945A1 (en) * 2003-10-28 2007-03-22 Martin Robin P Wound cleansing apparatus with scaffold
US20070219489A1 (en) * 2006-03-14 2007-09-20 Johnson Royce W Method for percutaneously administering reduced pressure treatment using balloon dissection
US20070265586A1 (en) * 2006-05-11 2007-11-15 Joshi Ashok V Device and method for wound therapy
US20070265585A1 (en) * 2006-05-11 2007-11-15 Joshi Ashok V Device and method for wound therapy
US20070293830A1 (en) * 2004-10-29 2007-12-20 Smith & Nephew, Plc Simultaneous Aspirate & Irrigate & Scaffold
US20080015640A1 (en) * 2006-06-28 2008-01-17 Kaiser Daniel E Method for histogenesis and enhancement of tissue
US20080275409A1 (en) * 2007-05-01 2008-11-06 The Brigham And Women's Hospital, Inc. Wound healing device
WO2009006226A1 (en) * 2007-06-29 2009-01-08 Kci Licensing Inc. Activation of bone and cartilage formation
US20090105671A1 (en) * 2005-11-25 2009-04-23 Daggar Anthony C Fibrous dressing
EP2106255A2 (en) * 2007-01-10 2009-10-07 Wake Forest University Health Sciences Apparatus and method for wound treatment employing periodic sub-atmospheric pressure
US20090299306A1 (en) * 2008-05-27 2009-12-03 John Buan Control unit with pump module for a negative pressure wound therapy device
WO2009158480A2 (en) * 2008-06-26 2009-12-30 Kci Licensing, Inc. Stimulation of cartilage formation using reduced pressure treatment
WO2010009294A1 (en) * 2008-07-18 2010-01-21 Wake Forest University Heath Sciences Apparatus and method for cardiac tissue modulation by topical application of vacuum to minimize cell death and damage
US20100042033A1 (en) * 2008-08-18 2010-02-18 Daron Carl Praetzel Tissue spacer for wound treatment employing reduced pressure and method and apparatus employing same
US20100160879A1 (en) * 2004-04-05 2010-06-24 Bluesky Medical Group Incorporated Reduced pressure wound treatment system
US20100168746A1 (en) * 2008-12-30 2010-07-01 Griffey Edward S Reduced pressure augmentation of microfracture procedures for cartilage repair
US20100168689A1 (en) * 2008-12-31 2010-07-01 Swain Larry D Systems for providing fluid flow to tissues
WO2010078345A2 (en) * 2008-12-31 2010-07-08 Kci Licensing, Inc. System for providing fluid flow to nerve tissues
US7790945B1 (en) 2004-04-05 2010-09-07 Kci Licensing, Inc. Wound dressing with absorption and suction capabilities
US20100297208A1 (en) * 2006-05-12 2010-11-25 Nicholas Fry Scaffold
US7846141B2 (en) 2002-09-03 2010-12-07 Bluesky Medical Group Incorporated Reduced pressure treatment system
US7909805B2 (en) 2004-04-05 2011-03-22 Bluesky Medical Group Incorporated Flexible reduced pressure treatment appliance
US7931651B2 (en) 2006-11-17 2011-04-26 Wake Lake University Health Sciences External fixation assembly and method of use
US7964766B2 (en) 2003-10-28 2011-06-21 Smith & Nephew Plc Wound cleansing apparatus in-situ
US7998125B2 (en) 2004-05-21 2011-08-16 Bluesky Medical Group Incorporated Hypobaric chamber treatment system
US20110230849A1 (en) * 2010-03-16 2011-09-22 Richard Daniel John Coulthard Delivery-and-fluid-storage bridges for use with reduced-pressure systems
USRE42834E1 (en) 2001-11-20 2011-10-11 Kci Licensing Inc. Personally portable vacuum desiccator
US8100887B2 (en) 2004-03-09 2012-01-24 Bluesky Medical Group Incorporated Enclosure-based reduced pressure treatment system
CN102333555A (en) * 2008-12-31 2012-01-25 凯希特许有限公司 Be used for manifold, the system and method for application of reduced pressure in the subcutaneous tissue position
US8162909B2 (en) 2005-09-15 2012-04-24 Smith & Nephew Plc Negative pressure wound treatment
US20120203144A1 (en) * 2011-02-07 2012-08-09 Kci Licensing, Inc. Methods and systems for treating a hoof on an ungulate mammal
US8267960B2 (en) 2008-01-09 2012-09-18 Wake Forest University Health Sciences Device and method for treating central nervous system pathology
CN102805702A (en) * 2012-08-28 2012-12-05 广州赞德利医疗科技有限公司 Electrocardiograph synchronous female breast disease and breast enlargement negative pressure rehabilitation therapeutic apparatus
US8398614B2 (en) 2002-10-28 2013-03-19 Smith & Nephew Plc Apparatus for aspirating, irrigating and cleansing wounds
US20130085427A1 (en) * 2011-09-29 2013-04-04 Tyco Healthcare Group Lp Compression garment having sealable bladder pocket
US8529548B2 (en) 2004-04-27 2013-09-10 Smith & Nephew Plc Wound treatment apparatus and method
US8540699B2 (en) 2004-04-05 2013-09-24 Bluesky Medical Group Incorporated Reduced pressure wound treatment system
US8663198B2 (en) 2009-04-17 2014-03-04 Kalypto Medical, Inc. Negative pressure wound therapy device
US8715256B2 (en) 2007-11-21 2014-05-06 Smith & Nephew Plc Vacuum assisted wound dressing
US8758313B2 (en) 2003-10-28 2014-06-24 Smith & Nephew Plc Apparatus and method for wound cleansing with actives
US8764732B2 (en) 2007-11-21 2014-07-01 Smith & Nephew Plc Wound dressing
US8795243B2 (en) 2004-05-21 2014-08-05 Bluesky Medical Group Incorporated Flexible reduced pressure treatment appliance
US8808274B2 (en) 2007-11-21 2014-08-19 Smith & Nephew Plc Wound dressing
US8829263B2 (en) 2005-09-07 2014-09-09 Smith & Nephew, Inc. Self contained wound dressing with micropump
US8834520B2 (en) 2007-10-10 2014-09-16 Wake Forest University Devices and methods for treating spinal cord tissue
US8926592B2 (en) 2003-10-28 2015-01-06 Smith & Nephew Plc Wound cleansing apparatus with heat
US8945074B2 (en) 2011-05-24 2015-02-03 Kalypto Medical, Inc. Device with controller and pump modules for providing negative pressure for wound therapy
EP2851098A1 (en) 2008-12-31 2015-03-25 KCI Licensing, Inc. Systems for inducing fluid flow to stimulate tissue growth
US20150119831A1 (en) 2013-10-30 2015-04-30 Kci Licensing, Inc. Condensate absorbing and dissipating system
US9033942B2 (en) 2008-03-07 2015-05-19 Smith & Nephew, Inc. Wound dressing port and associated wound dressing
US9058634B2 (en) 2011-05-24 2015-06-16 Kalypto Medical, Inc. Method for providing a negative pressure wound therapy pump device
US9061095B2 (en) 2010-04-27 2015-06-23 Smith & Nephew Plc Wound dressing and method of use
US9067003B2 (en) 2011-05-26 2015-06-30 Kalypto Medical, Inc. Method for providing negative pressure to a negative pressure wound therapy bandage
AU2013231068B2 (en) * 2007-06-29 2015-11-12 Kci Licensing Inc. Activation of bone and cartilage formation
US9370536B2 (en) 2012-09-26 2016-06-21 Lifecell Corporation Processed adipose tissue
US9474883B2 (en) 2012-12-06 2016-10-25 Ic Surgical, Inc. Adaptable wound drainage system
USD804014S1 (en) 2010-12-22 2017-11-28 Smith & Nephew, Inc. Suction adapter
US9861532B2 (en) 2011-12-16 2018-01-09 Kci Licensing, Inc. Releasable medical drapes
US9925092B2 (en) 2013-10-30 2018-03-27 Kci Licensing, Inc. Absorbent conduit and system
US9950100B2 (en) 2004-04-28 2018-04-24 Smith & Nephew Plc Negative pressure wound therapy dressing system
US9956120B2 (en) 2013-10-30 2018-05-01 Kci Licensing, Inc. Dressing with sealing and retention interface
US10010656B2 (en) 2008-03-05 2018-07-03 Kci Licensing, Inc. Dressing and method for applying reduced pressure to and collecting and storing fluid from a tissue site
US10016544B2 (en) 2013-10-30 2018-07-10 Kci Licensing, Inc. Dressing with differentially sized perforations
US10058642B2 (en) 2004-04-05 2018-08-28 Bluesky Medical Group Incorporated Reduced pressure treatment system
US10117978B2 (en) 2013-08-26 2018-11-06 Kci Licensing, Inc. Dressing interface with moisture controlling feature and sealing function
US10271995B2 (en) 2012-12-18 2019-04-30 Kci Usa, Inc. Wound dressing with adhesive margin
US10299966B2 (en) 2007-12-24 2019-05-28 Kci Usa, Inc. Reinforced adhesive backing sheet
US10357406B2 (en) 2011-04-15 2019-07-23 Kci Usa, Inc. Patterned silicone coating
US10398604B2 (en) 2014-12-17 2019-09-03 Kci Licensing, Inc. Dressing with offloading capability
US10406266B2 (en) 2014-05-02 2019-09-10 Kci Licensing, Inc. Fluid storage devices, systems, and methods
US10406037B2 (en) 2009-12-22 2019-09-10 Smith & Nephew, Inc. Apparatuses and methods for negative pressure wound therapy
US10561534B2 (en) 2014-06-05 2020-02-18 Kci Licensing, Inc. Dressing with fluid acquisition and distribution characteristics
US10568767B2 (en) 2011-01-31 2020-02-25 Kci Usa, Inc. Silicone wound dressing laminate and method for making the same
US10632020B2 (en) 2014-02-28 2020-04-28 Kci Licensing, Inc. Hybrid drape having a gel-coated perforated mesh
USRE48117E1 (en) 2010-05-07 2020-07-28 Smith & Nephew, Inc. Apparatuses and methods for negative pressure wound therapy
US10821205B2 (en) 2017-10-18 2020-11-03 Lifecell Corporation Adipose tissue products and methods of production
US10842707B2 (en) 2012-11-16 2020-11-24 Kci Licensing, Inc. Medical drape with pattern adhesive layers and method of manufacturing same
US10940047B2 (en) 2011-12-16 2021-03-09 Kci Licensing, Inc. Sealing systems and methods employing a hybrid switchable drape
US10946124B2 (en) 2013-10-28 2021-03-16 Kci Licensing, Inc. Hybrid sealing tape
US10973694B2 (en) 2015-09-17 2021-04-13 Kci Licensing, Inc. Hybrid silicone and acrylic adhesive cover for use with wound treatment
US11026844B2 (en) 2014-03-03 2021-06-08 Kci Licensing, Inc. Low profile flexible pressure transmission conduit
US11090338B2 (en) 2012-07-13 2021-08-17 Lifecell Corporation Methods for improved treatment of adipose tissue
US11096830B2 (en) 2015-09-01 2021-08-24 Kci Licensing, Inc. Dressing with increased apposition force
US11123375B2 (en) 2017-10-18 2021-09-21 Lifecell Corporation Methods of treating tissue voids following removal of implantable infusion ports using adipose tissue products
US11247034B2 (en) 2010-12-22 2022-02-15 Smith & Nephew, Inc. Apparatuses and methods for negative pressure wound therapy
US11246994B2 (en) 2017-10-19 2022-02-15 Lifecell Corporation Methods for introduction of flowable acellular tissue matrix products into a hand
US11246975B2 (en) 2015-05-08 2022-02-15 Kci Licensing, Inc. Low acuity dressing with integral pump
US11298453B2 (en) 2003-10-28 2022-04-12 Smith & Nephew Plc Apparatus and method for wound cleansing with actives
US11633521B2 (en) 2019-05-30 2023-04-25 Lifecell Corporation Biologic breast implant
US11819386B2 (en) 2018-07-12 2023-11-21 T.J.Smith And Nephew, Limited Apparatuses and methods for negative pressure wound therapy
US11826488B2 (en) 2017-10-19 2023-11-28 Lifecell Corporation Flowable acellular tissue matrix products and methods of production

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7128735B2 (en) 2004-01-02 2006-10-31 Richard Scott Weston Reduced pressure wound treatment appliance
AU2006321892B2 (en) * 2005-12-06 2010-06-17 3M Innovative Properties Company Wound exudate removal and isolation system
US8235939B2 (en) 2006-02-06 2012-08-07 Kci Licensing, Inc. System and method for purging a reduced pressure apparatus during the administration of reduced pressure treatment
US9456860B2 (en) 2006-03-14 2016-10-04 Kci Licensing, Inc. Bioresorbable foaming tissue dressing
JP4943497B2 (en) * 2006-03-14 2012-05-30 ケーシーアイ ライセンシング インコーポレイテッド System and method for purging a decompression device during decompression tissue treatment
CA2604623C (en) 2006-09-28 2018-10-30 Tyco Healthcare Group Lp Portable wound therapy system
US8267908B2 (en) 2007-02-09 2012-09-18 Kci Licensing, Inc. Delivery tube, system, and method for storing liquid from a tissue site
JP5038439B2 (en) 2007-02-09 2012-10-03 ケーシーアイ ライセンシング インコーポレイテッド Apparatus and method for applying reduced pressure treatment to a tissue site
US8377017B2 (en) * 2008-01-03 2013-02-19 Kci Licensing, Inc. Low-profile reduced pressure treatment system
US8187237B2 (en) 2008-05-30 2012-05-29 Kci Licensing, Inc Reduced-pressure, linear wound closing bolsters and systems
BRPI0909570A2 (en) 2008-05-30 2015-12-01 Kci Licensing Inc reduced pressure system for treating a linear wound in a patient, system for treating a linear wound in a patient, method of manufacturing a system for treating a linear wound in a patient
US20100324516A1 (en) 2009-06-18 2010-12-23 Tyco Healthcare Group Lp Apparatus for Vacuum Bridging and/or Exudate Collection
US9265665B2 (en) * 2010-07-19 2016-02-23 Kci Licensing, Inc. Inflatable off-loading wound dressing assemblies, systems, and methods
CN107126290B (en) * 2017-04-26 2021-07-09 吴恩德 Artificial optic nerve casing for experimental animal

Citations (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US212121A (en) * 1879-02-11 Improvement in life-rafts
US1385346A (en) * 1919-06-27 1921-07-19 Taylor Walter Herbert Surgical wound-dam
US2122121A (en) * 1937-02-02 1938-06-28 Tillotson Joseph Elmer Surgical aspirated drainage cup
US2195771A (en) * 1937-11-09 1940-04-02 Estler Louis Edmond Surgical suction drainage cup
US2232254A (en) * 1936-05-26 1941-02-18 Samuel Schadel Massage device
US2280915A (en) * 1941-04-03 1942-04-28 John H Johnson Device for irrigating and treating wounds
US2338339A (en) * 1940-11-08 1944-01-04 Mere Massaging vibrator
US2547758A (en) * 1949-01-05 1951-04-03 Wilmer B Keeling Instrument for treating the male urethra
US2969057A (en) * 1957-11-04 1961-01-24 Brady Co W H Nematodic swab
US3026874A (en) * 1959-11-06 1962-03-27 Robert C Stevens Wound shield
US3026526A (en) * 1959-01-19 1962-03-27 Montrose Arthur Bathing cap
US3042041A (en) * 1960-03-09 1962-07-03 Mario E Jascalevich Device for draining wounds
US3324855A (en) * 1965-01-12 1967-06-13 Henry J Heimlich Surgical sponge stick
US3367332A (en) * 1965-08-27 1968-02-06 Gen Electric Product and process for establishing a sterile area of skin
US3382867A (en) * 1965-03-22 1968-05-14 Ruby L. Reaves Body portion developing device with combined vacuum and vibrating means
US3520300A (en) * 1967-03-15 1970-07-14 Amp Inc Surgical sponge and suction device
US3568675A (en) * 1968-08-30 1971-03-09 Clyde B Harvey Fistula and penetrating wound dressing
US3572340A (en) * 1968-01-11 1971-03-23 Kendall & Co Suction drainage device
US3682180A (en) * 1970-06-08 1972-08-08 Coilform Co Inc Drain clip for surgical drain
US3713622A (en) * 1971-02-26 1973-01-30 Amp Inc Closure device for flexible tubing
US3753439A (en) * 1971-08-24 1973-08-21 Elias & Brugarolas General purpose surgical drain
US3826254A (en) * 1973-02-26 1974-07-30 Verco Ind Needle or catheter retaining appliance
US3874387A (en) * 1972-07-05 1975-04-01 Pasquale P Barbieri Valved hemostatic pressure cap
US3896810A (en) * 1972-12-27 1975-07-29 Hiroshi Akiyama Aspirator for removal of the contents of cystic tumors
US3938540A (en) * 1971-10-07 1976-02-17 Medical Development Corporation Vacuum-operated fluid bottle for tandem systems
US3954105A (en) * 1973-10-01 1976-05-04 Hollister Incorporated Drainage system for incisions or wounds in the body of an animal
US4080970A (en) * 1976-11-17 1978-03-28 Miller Thomas J Post-operative combination dressing and internal drain tube with external shield and tube connector
US4139004A (en) * 1977-02-17 1979-02-13 Gonzalez Jr Harry Bandage apparatus for treating burns
US4149541A (en) * 1977-10-06 1979-04-17 Moore-Perk Corporation Fluid circulating pad
US4184510A (en) * 1977-03-15 1980-01-22 Fibra-Sonics, Inc. Valued device for controlling vacuum in surgery
US4187852A (en) * 1976-07-09 1980-02-12 The University Of Alabama Synthetic elastomeric insoluble cross-linked polypentapeptide
US4250882A (en) * 1979-01-26 1981-02-17 Medical Dynamics, Inc. Wound drainage device
US4256109A (en) * 1978-07-10 1981-03-17 Nichols Robert L Shut off valve for medical suction apparatus
US4261363A (en) * 1979-11-09 1981-04-14 C. R. Bard, Inc. Retention clips for body fluid drains
US4275721A (en) * 1978-11-28 1981-06-30 Landstingens Inkopscentral Lic, Ekonomisk Forening Vein catheter bandage
US4373519A (en) * 1981-06-26 1983-02-15 Minnesota Mining And Manufacturing Company Composite wound dressing
US4382441A (en) * 1978-12-06 1983-05-10 Svedman Paul Device for treating tissues, for example skin
US4392853A (en) * 1981-03-16 1983-07-12 Rudolph Muto Sterile assembly for protecting and fastening an indwelling device
US4452845A (en) * 1980-08-13 1984-06-05 Smith And Nephew Associated Companies Limited Moisture vapor transmitting film of polyurethane blended with an incompatible polymer
US4459139A (en) * 1981-09-14 1984-07-10 Gelman Sciences Inc. Disposable filter device and liquid aspirating system incorporating same
US4465485A (en) * 1981-03-06 1984-08-14 Becton, Dickinson And Company Suction canister with unitary shut-off valve and filter features
US4465062A (en) * 1982-05-14 1984-08-14 Gina Versaggi Noninvasive seal for a sucking chest wound
USRE31887E (en) * 1968-07-09 1985-05-14 T. J. Smith & Nephew Limited Moisture-vapor-permeable pressure-sensitive adhesive materials
US4525166A (en) * 1981-11-21 1985-06-25 Intermedicat Gmbh Rolled flexible medical suction drainage device
US4527064A (en) * 1980-10-29 1985-07-02 The United States Of America As Represented By The United States Department Of Energy Imaging alpha particle detector
US4569674A (en) * 1982-08-03 1986-02-11 Stryker Corporation Continuous vacuum wound drainage system
US4573965A (en) * 1984-02-13 1986-03-04 Superior Plastic Products Corp. Device for draining wounds
US4640688A (en) * 1985-08-23 1987-02-03 Mentor Corporation Urine collection catheter
US4655754A (en) * 1984-11-09 1987-04-07 Stryker Corporation Vacuum wound drainage system and lipids baffle therefor
US4661093A (en) * 1983-06-11 1987-04-28 Walter Beck Method for aspirating secreted fluids from a wound
US4664662A (en) * 1984-08-02 1987-05-12 Smith And Nephew Associated Companies Plc Wound dressing
US4717382A (en) * 1985-04-18 1988-01-05 Emergency Management Products, Inc. Noninvasive apparatus for treating a sucking chest wound
US4743232A (en) * 1986-10-06 1988-05-10 The Clinipad Corporation Package assembly for plastic film bandage
US4753231A (en) * 1981-02-13 1988-06-28 Smith & Nephew Associated Companies P.L.C. Adhesive wound dressing
US4759354A (en) * 1986-11-26 1988-07-26 The Kendall Company Wound dressing
US4820284A (en) * 1986-04-24 1989-04-11 Genossenschaft Vebo Solothurnische Eingliederungsstatte Fur Behinderte Suction device for the drainage of wounds and use of the device
US4820265A (en) * 1986-12-16 1989-04-11 Minnesota Mining And Manufacturing Company Tubing set
US4834110A (en) * 1988-02-01 1989-05-30 Richard Patricia A Suction clamped treatment cup saliva sampler
US4836192A (en) * 1982-09-20 1989-06-06 Mariarosa Abbate Vacuum generator for stimulating the scalp
US4838883A (en) * 1986-03-07 1989-06-13 Nissho Corporation Urine-collecting device
US4840187A (en) * 1986-09-11 1989-06-20 Bard Limited Sheath applicator
US4841962A (en) * 1984-03-27 1989-06-27 Berg Richard A Collagen matrix/polymer film composite dressing
US4851545A (en) * 1987-06-02 1989-07-25 Warner-Lambert Company N-substituted-3-alkylene-2-pyrrolidone compounds
US4906233A (en) * 1986-05-29 1990-03-06 Terumo Kabushiki Kaisha Method of securing a catheter body to a human skin surface
US4917112A (en) * 1988-08-22 1990-04-17 Kalt Medical Corp. Universal bandage with transparent dressing
US4921492A (en) * 1988-05-31 1990-05-01 Laser Technologies Group, Inc. End effector for surgical plume evacuator
US4925447A (en) * 1988-06-22 1990-05-15 Rosenblatt/Ima Invention Enterprises Aspirator without partition wall for collection of bodily fluids including improved safety and efficiency elements
US4931519A (en) * 1987-06-02 1990-06-05 Warner-Lambert Company Copolymers from n-alkyl-3-alkenylene-2-pyrrolidone
US4941882A (en) * 1987-03-14 1990-07-17 Smith And Nephew Associated Companies, P.L.C. Adhesive dressing for retaining a cannula on the skin
US5035884A (en) * 1987-06-02 1991-07-30 Warner-Lambert Company Methylene pyrrolidone copolymers for contact lens and pharmaceutical preparations
US5086764A (en) * 1989-04-13 1992-02-11 Thomas Gilman Absorbent dressing
US5100396A (en) * 1989-04-03 1992-03-31 Zamierowski David S Fluidic connection system and method
US5106362A (en) * 1989-04-13 1992-04-21 The Kendall Company Vented absorbent dressing
US5113871A (en) * 1987-07-13 1992-05-19 Jouko Viljanto Device for the determination of incisional wound healing ability
US5228431A (en) * 1990-04-26 1993-07-20 Giarretto Ralph R Drug-free method for treatment of the scalp for therapeutic purposes
US5496262A (en) * 1994-01-06 1996-03-05 Aircast, Inc. Therapeutic intermittent compression system with inflatable compartments of differing pressure from a single source
US5527293A (en) * 1989-04-03 1996-06-18 Kinetic Concepts, Inc. Fastening system and method
US5636643A (en) * 1991-11-14 1997-06-10 Wake Forest University Wound treatment employing reduced pressure
US5645081A (en) * 1991-11-14 1997-07-08 Wake Forest University Method of treating tissue damage and apparatus for same
US5717030A (en) * 1994-04-08 1998-02-10 Atrix Laboratories, Inc. Adjunctive polymer system for use with medical device
US5733884A (en) * 1995-11-07 1998-03-31 Nestec Ltd. Enteral formulation designed for optimized wound healing
US5736372A (en) * 1986-11-20 1998-04-07 Massachusetts Institute Of Technology Biodegradable synthetic polymeric fibrous matrix containing chondrocyte for in vivo production of a cartilaginous structure
US5766618A (en) * 1994-04-01 1998-06-16 Massachusetts Institute Of Technology Polymeric-hydroxyapatite bone composite
US6071267A (en) * 1998-02-06 2000-06-06 Kinetic Concepts, Inc. Medical patient fluid management interface system and method
US6174306B1 (en) * 1995-05-13 2001-01-16 Wim Fleischmann Device for vacuum-sealing an injury
US6187047B1 (en) * 1995-10-16 2001-02-13 Orquest, Inc. Bone grafting matrix
US6345623B1 (en) * 1997-09-12 2002-02-12 Keith Patrick Heaton Surgical drape and suction head for wound treatment
US6398767B1 (en) * 1997-05-27 2002-06-04 Wilhelm Fleischmann Process and device for application of active substances to a wound surface area
US6520982B1 (en) * 2000-06-08 2003-02-18 Kci Licensing, Inc. Localized liquid therapy and thermotherapy device
US6551317B2 (en) * 2000-06-07 2003-04-22 Aircast, Inc. Method and apparatus for facilitating the healing of bone fractures
US6695823B1 (en) * 1999-04-09 2004-02-24 Kci Licensing, Inc. Wound therapy device
US6767334B1 (en) * 1998-12-23 2004-07-27 Kci Licensing, Inc. Method and apparatus for wound treatment
US6856821B2 (en) * 2000-05-26 2005-02-15 Kci Licensing, Inc. System for combined transcutaneous blood gas monitoring and vacuum assisted wound closure
US6994702B1 (en) * 1999-04-06 2006-02-07 Kci Licensing, Inc. Vacuum assisted closure pad with adaptation for phototherapy
US7004915B2 (en) * 2001-08-24 2006-02-28 Kci Licensing, Inc. Negative pressure assisted tissue treatment system
US7070584B2 (en) * 2001-02-20 2006-07-04 Kci Licensing, Inc. Biocompatible wound dressing
US7169151B1 (en) * 2003-04-10 2007-01-30 Kci Licensing, Inc. Bone regeneration device for long bones, and method of use

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4302708C2 (en) * 1993-02-01 1995-06-01 Kirsch Axel Covering membrane
US6136029A (en) * 1997-10-01 2000-10-24 Phillips-Origen Ceramic Technology, Llc Bone substitute materials
WO1999051164A1 (en) * 1998-04-03 1999-10-14 Reprogenesis, Inc. Soft tissue reconstructor and method of use
US6306424B1 (en) * 1999-06-30 2001-10-23 Ethicon, Inc. Foam composite for the repair or regeneration of tissue
AU2001261595A1 (en) * 2000-05-22 2001-12-03 Arthur C. Coffey Combination sis and vacuum bandage and method
CN1146368C (en) * 2000-12-15 2004-04-21 四川大学华西医院 Bio-derivative tissue engineering bone and its preparing process
CN1164338C (en) * 2001-06-29 2004-09-01 清华大学 Process for preparing nm-phase calcium-phosphorus salt/collagen/high-molecular bone compounded porous material

Patent Citations (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US212121A (en) * 1879-02-11 Improvement in life-rafts
US1385346A (en) * 1919-06-27 1921-07-19 Taylor Walter Herbert Surgical wound-dam
US2232254A (en) * 1936-05-26 1941-02-18 Samuel Schadel Massage device
US2122121A (en) * 1937-02-02 1938-06-28 Tillotson Joseph Elmer Surgical aspirated drainage cup
US2195771A (en) * 1937-11-09 1940-04-02 Estler Louis Edmond Surgical suction drainage cup
US2338339A (en) * 1940-11-08 1944-01-04 Mere Massaging vibrator
US2280915A (en) * 1941-04-03 1942-04-28 John H Johnson Device for irrigating and treating wounds
US2547758A (en) * 1949-01-05 1951-04-03 Wilmer B Keeling Instrument for treating the male urethra
US2969057A (en) * 1957-11-04 1961-01-24 Brady Co W H Nematodic swab
US3026526A (en) * 1959-01-19 1962-03-27 Montrose Arthur Bathing cap
US3026874A (en) * 1959-11-06 1962-03-27 Robert C Stevens Wound shield
US3042041A (en) * 1960-03-09 1962-07-03 Mario E Jascalevich Device for draining wounds
US3324855A (en) * 1965-01-12 1967-06-13 Henry J Heimlich Surgical sponge stick
US3382867A (en) * 1965-03-22 1968-05-14 Ruby L. Reaves Body portion developing device with combined vacuum and vibrating means
US3367332A (en) * 1965-08-27 1968-02-06 Gen Electric Product and process for establishing a sterile area of skin
US3520300A (en) * 1967-03-15 1970-07-14 Amp Inc Surgical sponge and suction device
US3572340A (en) * 1968-01-11 1971-03-23 Kendall & Co Suction drainage device
USRE31887E (en) * 1968-07-09 1985-05-14 T. J. Smith & Nephew Limited Moisture-vapor-permeable pressure-sensitive adhesive materials
US3568675A (en) * 1968-08-30 1971-03-09 Clyde B Harvey Fistula and penetrating wound dressing
US3682180A (en) * 1970-06-08 1972-08-08 Coilform Co Inc Drain clip for surgical drain
US3713622A (en) * 1971-02-26 1973-01-30 Amp Inc Closure device for flexible tubing
US3753439A (en) * 1971-08-24 1973-08-21 Elias & Brugarolas General purpose surgical drain
US3938540A (en) * 1971-10-07 1976-02-17 Medical Development Corporation Vacuum-operated fluid bottle for tandem systems
US3874387A (en) * 1972-07-05 1975-04-01 Pasquale P Barbieri Valved hemostatic pressure cap
US3896810A (en) * 1972-12-27 1975-07-29 Hiroshi Akiyama Aspirator for removal of the contents of cystic tumors
US3826254A (en) * 1973-02-26 1974-07-30 Verco Ind Needle or catheter retaining appliance
US3954105A (en) * 1973-10-01 1976-05-04 Hollister Incorporated Drainage system for incisions or wounds in the body of an animal
US4187852A (en) * 1976-07-09 1980-02-12 The University Of Alabama Synthetic elastomeric insoluble cross-linked polypentapeptide
US4080970A (en) * 1976-11-17 1978-03-28 Miller Thomas J Post-operative combination dressing and internal drain tube with external shield and tube connector
US4139004A (en) * 1977-02-17 1979-02-13 Gonzalez Jr Harry Bandage apparatus for treating burns
US4184510A (en) * 1977-03-15 1980-01-22 Fibra-Sonics, Inc. Valued device for controlling vacuum in surgery
US4149541A (en) * 1977-10-06 1979-04-17 Moore-Perk Corporation Fluid circulating pad
US4256109A (en) * 1978-07-10 1981-03-17 Nichols Robert L Shut off valve for medical suction apparatus
US4275721A (en) * 1978-11-28 1981-06-30 Landstingens Inkopscentral Lic, Ekonomisk Forening Vein catheter bandage
US4382441A (en) * 1978-12-06 1983-05-10 Svedman Paul Device for treating tissues, for example skin
US4250882A (en) * 1979-01-26 1981-02-17 Medical Dynamics, Inc. Wound drainage device
US4261363A (en) * 1979-11-09 1981-04-14 C. R. Bard, Inc. Retention clips for body fluid drains
US4452845A (en) * 1980-08-13 1984-06-05 Smith And Nephew Associated Companies Limited Moisture vapor transmitting film of polyurethane blended with an incompatible polymer
US4527064A (en) * 1980-10-29 1985-07-02 The United States Of America As Represented By The United States Department Of Energy Imaging alpha particle detector
US4753231A (en) * 1981-02-13 1988-06-28 Smith & Nephew Associated Companies P.L.C. Adhesive wound dressing
US4465485A (en) * 1981-03-06 1984-08-14 Becton, Dickinson And Company Suction canister with unitary shut-off valve and filter features
US4392853A (en) * 1981-03-16 1983-07-12 Rudolph Muto Sterile assembly for protecting and fastening an indwelling device
US4373519A (en) * 1981-06-26 1983-02-15 Minnesota Mining And Manufacturing Company Composite wound dressing
US4459139A (en) * 1981-09-14 1984-07-10 Gelman Sciences Inc. Disposable filter device and liquid aspirating system incorporating same
US4525166A (en) * 1981-11-21 1985-06-25 Intermedicat Gmbh Rolled flexible medical suction drainage device
US4465062A (en) * 1982-05-14 1984-08-14 Gina Versaggi Noninvasive seal for a sucking chest wound
US4569674A (en) * 1982-08-03 1986-02-11 Stryker Corporation Continuous vacuum wound drainage system
US4836192A (en) * 1982-09-20 1989-06-06 Mariarosa Abbate Vacuum generator for stimulating the scalp
US4661093A (en) * 1983-06-11 1987-04-28 Walter Beck Method for aspirating secreted fluids from a wound
US4573965A (en) * 1984-02-13 1986-03-04 Superior Plastic Products Corp. Device for draining wounds
US4841962A (en) * 1984-03-27 1989-06-27 Berg Richard A Collagen matrix/polymer film composite dressing
US4664662A (en) * 1984-08-02 1987-05-12 Smith And Nephew Associated Companies Plc Wound dressing
US4655754A (en) * 1984-11-09 1987-04-07 Stryker Corporation Vacuum wound drainage system and lipids baffle therefor
US4717382A (en) * 1985-04-18 1988-01-05 Emergency Management Products, Inc. Noninvasive apparatus for treating a sucking chest wound
US4640688A (en) * 1985-08-23 1987-02-03 Mentor Corporation Urine collection catheter
US4838883A (en) * 1986-03-07 1989-06-13 Nissho Corporation Urine-collecting device
US4820284A (en) * 1986-04-24 1989-04-11 Genossenschaft Vebo Solothurnische Eingliederungsstatte Fur Behinderte Suction device for the drainage of wounds and use of the device
US4906233A (en) * 1986-05-29 1990-03-06 Terumo Kabushiki Kaisha Method of securing a catheter body to a human skin surface
US4840187A (en) * 1986-09-11 1989-06-20 Bard Limited Sheath applicator
US4743232A (en) * 1986-10-06 1988-05-10 The Clinipad Corporation Package assembly for plastic film bandage
US5736372A (en) * 1986-11-20 1998-04-07 Massachusetts Institute Of Technology Biodegradable synthetic polymeric fibrous matrix containing chondrocyte for in vivo production of a cartilaginous structure
US4759354A (en) * 1986-11-26 1988-07-26 The Kendall Company Wound dressing
US4820265A (en) * 1986-12-16 1989-04-11 Minnesota Mining And Manufacturing Company Tubing set
US4941882A (en) * 1987-03-14 1990-07-17 Smith And Nephew Associated Companies, P.L.C. Adhesive dressing for retaining a cannula on the skin
US4851545A (en) * 1987-06-02 1989-07-25 Warner-Lambert Company N-substituted-3-alkylene-2-pyrrolidone compounds
US5035884A (en) * 1987-06-02 1991-07-30 Warner-Lambert Company Methylene pyrrolidone copolymers for contact lens and pharmaceutical preparations
US4931519A (en) * 1987-06-02 1990-06-05 Warner-Lambert Company Copolymers from n-alkyl-3-alkenylene-2-pyrrolidone
US5113871A (en) * 1987-07-13 1992-05-19 Jouko Viljanto Device for the determination of incisional wound healing ability
US4834110A (en) * 1988-02-01 1989-05-30 Richard Patricia A Suction clamped treatment cup saliva sampler
US4921492A (en) * 1988-05-31 1990-05-01 Laser Technologies Group, Inc. End effector for surgical plume evacuator
US4925447A (en) * 1988-06-22 1990-05-15 Rosenblatt/Ima Invention Enterprises Aspirator without partition wall for collection of bodily fluids including improved safety and efficiency elements
US4917112A (en) * 1988-08-22 1990-04-17 Kalt Medical Corp. Universal bandage with transparent dressing
US5100396A (en) * 1989-04-03 1992-03-31 Zamierowski David S Fluidic connection system and method
US5527293A (en) * 1989-04-03 1996-06-18 Kinetic Concepts, Inc. Fastening system and method
US5086764A (en) * 1989-04-13 1992-02-11 Thomas Gilman Absorbent dressing
US5106362A (en) * 1989-04-13 1992-04-21 The Kendall Company Vented absorbent dressing
US5228431A (en) * 1990-04-26 1993-07-20 Giarretto Ralph R Drug-free method for treatment of the scalp for therapeutic purposes
US5636643A (en) * 1991-11-14 1997-06-10 Wake Forest University Wound treatment employing reduced pressure
US5645081A (en) * 1991-11-14 1997-07-08 Wake Forest University Method of treating tissue damage and apparatus for same
US5496262A (en) * 1994-01-06 1996-03-05 Aircast, Inc. Therapeutic intermittent compression system with inflatable compartments of differing pressure from a single source
US5766618A (en) * 1994-04-01 1998-06-16 Massachusetts Institute Of Technology Polymeric-hydroxyapatite bone composite
US5717030A (en) * 1994-04-08 1998-02-10 Atrix Laboratories, Inc. Adjunctive polymer system for use with medical device
US6174306B1 (en) * 1995-05-13 2001-01-16 Wim Fleischmann Device for vacuum-sealing an injury
US6187047B1 (en) * 1995-10-16 2001-02-13 Orquest, Inc. Bone grafting matrix
US5733884A (en) * 1995-11-07 1998-03-31 Nestec Ltd. Enteral formulation designed for optimized wound healing
US6398767B1 (en) * 1997-05-27 2002-06-04 Wilhelm Fleischmann Process and device for application of active substances to a wound surface area
US7077832B2 (en) * 1997-05-27 2006-07-18 Kci Licensing, Inc. Process and device for application of active substances to a wound surface
US6553998B2 (en) * 1997-09-12 2003-04-29 Kci Licensing, Inc. Surgical drape and suction head for wound treatment
US6345623B1 (en) * 1997-09-12 2002-02-12 Keith Patrick Heaton Surgical drape and suction head for wound treatment
US6071267A (en) * 1998-02-06 2000-06-06 Kinetic Concepts, Inc. Medical patient fluid management interface system and method
US6767334B1 (en) * 1998-12-23 2004-07-27 Kci Licensing, Inc. Method and apparatus for wound treatment
US6994702B1 (en) * 1999-04-06 2006-02-07 Kci Licensing, Inc. Vacuum assisted closure pad with adaptation for phototherapy
US6695823B1 (en) * 1999-04-09 2004-02-24 Kci Licensing, Inc. Wound therapy device
US6856821B2 (en) * 2000-05-26 2005-02-15 Kci Licensing, Inc. System for combined transcutaneous blood gas monitoring and vacuum assisted wound closure
US6551317B2 (en) * 2000-06-07 2003-04-22 Aircast, Inc. Method and apparatus for facilitating the healing of bone fractures
US6520982B1 (en) * 2000-06-08 2003-02-18 Kci Licensing, Inc. Localized liquid therapy and thermotherapy device
US7070584B2 (en) * 2001-02-20 2006-07-04 Kci Licensing, Inc. Biocompatible wound dressing
US7004915B2 (en) * 2001-08-24 2006-02-28 Kci Licensing, Inc. Negative pressure assisted tissue treatment system
US7169151B1 (en) * 2003-04-10 2007-01-30 Kci Licensing, Inc. Bone regeneration device for long bones, and method of use

Cited By (247)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7494482B2 (en) 2001-05-15 2009-02-24 The Brigham And Women's Hospital, Inc. Methods and apparatus for application of micro-mechanical forces to tissues
US20030108587A1 (en) * 2001-05-15 2003-06-12 Orgill Dennis P. Methods and apparatus for application of micro-mechanical forces to tissues
USRE42834E1 (en) 2001-11-20 2011-10-11 Kci Licensing Inc. Personally portable vacuum desiccator
US8062273B2 (en) 2002-09-03 2011-11-22 Bluesky Medical Group Incorporated Reduced pressure treatment system
US11298454B2 (en) 2002-09-03 2022-04-12 Smith & Nephew, Inc. Reduced pressure treatment system
US9211365B2 (en) 2002-09-03 2015-12-15 Bluesky Medical Group, Inc. Reduced pressure treatment system
US10265445B2 (en) 2002-09-03 2019-04-23 Smith & Nephew, Inc. Reduced pressure treatment system
US11376356B2 (en) 2002-09-03 2022-07-05 Smith & Nephew, Inc. Reduced pressure treatment system
US8628505B2 (en) 2002-09-03 2014-01-14 Bluesky Medical Group Incorporated Reduced pressure treatment system
US8545464B2 (en) 2002-09-03 2013-10-01 Bluesky Medical Group Incorporated Reduced pressure treatment system
US7846141B2 (en) 2002-09-03 2010-12-07 Bluesky Medical Group Incorporated Reduced pressure treatment system
US9205001B2 (en) 2002-10-28 2015-12-08 Smith & Nephew Plc Apparatus for aspirating, irrigating and cleansing wounds
US10278869B2 (en) 2002-10-28 2019-05-07 Smith & Nephew Plc Apparatus for aspirating, irrigating and cleansing wounds
US8834451B2 (en) 2002-10-28 2014-09-16 Smith & Nephew Plc In-situ wound cleansing apparatus
US8398614B2 (en) 2002-10-28 2013-03-19 Smith & Nephew Plc Apparatus for aspirating, irrigating and cleansing wounds
US9844473B2 (en) 2002-10-28 2017-12-19 Smith & Nephew Plc Apparatus for aspirating, irrigating and cleansing wounds
US10842678B2 (en) 2002-10-28 2020-11-24 Smith & Nephew Plc Apparatus for aspirating, irrigating and cleansing wounds
US9844474B2 (en) 2002-10-28 2017-12-19 Smith & Nephew Plc Apparatus for aspirating, irrigating and cleansing wounds
US8109932B2 (en) 2003-04-10 2012-02-07 Kci Licensing, Inc. Bone regeneration device for bones, and method of use
US7169151B1 (en) 2003-04-10 2007-01-30 Kci Licensing, Inc. Bone regeneration device for long bones, and method of use
US20070123895A1 (en) * 2003-04-10 2007-05-31 Kci Licensing, Inc. Bone regeneration device for bones, and method of use
US7361184B2 (en) 2003-09-08 2008-04-22 Joshi Ashok V Device and method for wound therapy
US20080183119A1 (en) * 2003-09-08 2008-07-31 Joshi Ashok V Electrochemical Wound Therapy Device
US20090131888A1 (en) * 2003-09-08 2009-05-21 Joshi Ashok V Electrochemical Negative Pressure Wound Therapy Device
US8012169B2 (en) 2003-09-08 2011-09-06 Microlin, Llc Electrochemical wound therapy device
US8353928B2 (en) 2003-09-08 2013-01-15 Ceramatec, Inc. Electrochemical wound therapy
US20050070835A1 (en) * 2003-09-08 2005-03-31 Joshi Ashok V. Device and method for wound therapy
US20080188820A1 (en) * 2003-09-08 2008-08-07 Joshi Ashok V Capillary-Action Wound Therapy Device
US8569566B2 (en) 2003-10-28 2013-10-29 Smith & Nephew, Plc Wound cleansing apparatus in-situ
US11298453B2 (en) 2003-10-28 2022-04-12 Smith & Nephew Plc Apparatus and method for wound cleansing with actives
US20070066945A1 (en) * 2003-10-28 2007-03-22 Martin Robin P Wound cleansing apparatus with scaffold
US8926592B2 (en) 2003-10-28 2015-01-06 Smith & Nephew Plc Wound cleansing apparatus with heat
US8882746B2 (en) 2003-10-28 2014-11-11 Smith & Nephew Plc Wound cleansing apparatus with scaffold
US9289542B2 (en) 2003-10-28 2016-03-22 Smith & Nephew Plc Wound cleansing apparatus
US8758313B2 (en) 2003-10-28 2014-06-24 Smith & Nephew Plc Apparatus and method for wound cleansing with actives
US9446178B2 (en) 2003-10-28 2016-09-20 Smith & Nephew Plc Wound cleansing apparatus in-situ
US9452248B2 (en) 2003-10-28 2016-09-27 Smith & Nephew Plc Wound cleansing apparatus in-situ
US8080702B2 (en) 2003-10-28 2011-12-20 Smith & Nephew Plc Wound cleansing apparatus in-situ
US20100274167A1 (en) * 2003-10-28 2010-10-28 Smith & Nephew Plc Wound cleansing apparatus with scaffold
US9616208B2 (en) 2003-10-28 2017-04-11 Smith & Nephew Plc Wound cleansing apparatus
US7699830B2 (en) 2003-10-28 2010-04-20 Smith & Nephew Plc Wound cleansing apparatus with scaffold
US7964766B2 (en) 2003-10-28 2011-06-21 Smith & Nephew Plc Wound cleansing apparatus in-situ
US8128615B2 (en) 2003-10-28 2012-03-06 Smith & Nephew Plc Wound cleansing apparatus with scaffold
US8100887B2 (en) 2004-03-09 2012-01-24 Bluesky Medical Group Incorporated Enclosure-based reduced pressure treatment system
US8708998B2 (en) 2004-03-09 2014-04-29 Bluesky Medical Group, Inc. Enclosure-based reduced pressure treatment system
US8303552B2 (en) 2004-04-05 2012-11-06 Bluesky Medical Group, Inc. Reduced pressure wound treatment system
US8282611B2 (en) 2004-04-05 2012-10-09 Bluesky Medical Group, Inc. Reduced pressure wound treatment system
US9492326B2 (en) 2004-04-05 2016-11-15 Bluesky Medical Group Incorporated Reduced pressure wound treatment system
US10058642B2 (en) 2004-04-05 2018-08-28 Bluesky Medical Group Incorporated Reduced pressure treatment system
US9198801B2 (en) 2004-04-05 2015-12-01 Bluesky Medical Group, Inc. Flexible reduced pressure treatment appliance
US10363346B2 (en) 2004-04-05 2019-07-30 Smith & Nephew, Inc. Flexible reduced pressure treatment appliance
US8540699B2 (en) 2004-04-05 2013-09-24 Bluesky Medical Group Incorporated Reduced pressure wound treatment system
US10105471B2 (en) 2004-04-05 2018-10-23 Smith & Nephew, Inc. Reduced pressure treatment system
US8449509B2 (en) 2004-04-05 2013-05-28 Bluesky Medical Group Incorporated Flexible reduced pressure treatment appliance
US20100160879A1 (en) * 2004-04-05 2010-06-24 Bluesky Medical Group Incorporated Reduced pressure wound treatment system
US7790945B1 (en) 2004-04-05 2010-09-07 Kci Licensing, Inc. Wound dressing with absorption and suction capabilities
US20110087180A2 (en) * 2004-04-05 2011-04-14 Bluesky Medical Group Incorporated Reduced pressure wound treatment system
US8084663B2 (en) 2004-04-05 2011-12-27 Kci Licensing, Inc. Wound dressing with absorption and suction capabilities
US20110087177A2 (en) * 2004-04-05 2011-04-14 Bluesky Medical Group Incorporated Reduced pressure wound treatment system
US10842919B2 (en) 2004-04-05 2020-11-24 Smith & Nephew, Inc. Reduced pressure treatment system
US11730874B2 (en) 2004-04-05 2023-08-22 Smith & Nephew, Inc. Reduced pressure treatment appliance
US7909805B2 (en) 2004-04-05 2011-03-22 Bluesky Medical Group Incorporated Flexible reduced pressure treatment appliance
US20100174251A1 (en) * 2004-04-05 2010-07-08 Bluesky Medical Group Incorporated Reduced pressure wound treatment system
US10350339B2 (en) 2004-04-05 2019-07-16 Smith & Nephew, Inc. Flexible reduced pressure treatment appliance
US8845619B2 (en) 2004-04-27 2014-09-30 Smith & Nephew Plc Wound treatment apparatus and method
US8529548B2 (en) 2004-04-27 2013-09-10 Smith & Nephew Plc Wound treatment apparatus and method
US10758424B2 (en) 2004-04-28 2020-09-01 Smith & Nephew Plc Dressing and apparatus for cleansing the wounds
US9950100B2 (en) 2004-04-28 2018-04-24 Smith & Nephew Plc Negative pressure wound therapy dressing system
US9545463B2 (en) 2004-04-28 2017-01-17 Smith & Nephew Plc Wound treatment apparatus and method
US10039868B2 (en) 2004-04-28 2018-08-07 Smith & Nephew Plc Dressing and apparatus for cleansing the wounds
US10758425B2 (en) 2004-04-28 2020-09-01 Smith & Nephew Plc Negative pressure wound therapy dressing system
US10207035B2 (en) 2004-05-21 2019-02-19 Smith & Nephew, Inc. Flexible reduced pressure treatment appliance
US9272080B2 (en) 2004-05-21 2016-03-01 Bluesky Medical Group Incorporated Flexible reduced pressure treatment appliance
US8795243B2 (en) 2004-05-21 2014-08-05 Bluesky Medical Group Incorporated Flexible reduced pressure treatment appliance
US7998125B2 (en) 2004-05-21 2011-08-16 Bluesky Medical Group Incorporated Hypobaric chamber treatment system
US9925313B2 (en) 2004-05-21 2018-03-27 Smith & Nephew, Inc. Flexible reduced pressure treatment appliance
US20070293830A1 (en) * 2004-10-29 2007-12-20 Smith & Nephew, Plc Simultaneous Aspirate & Irrigate & Scaffold
US7883494B2 (en) 2004-10-29 2011-02-08 Smith & Nephew Plc Simultaneous aspirate and irrigate and scaffold
US8829263B2 (en) 2005-09-07 2014-09-09 Smith & Nephew, Inc. Self contained wound dressing with micropump
US11737925B2 (en) 2005-09-07 2023-08-29 Smith & Nephew, Inc. Self contained wound dressing with micropump
US11278658B2 (en) 2005-09-07 2022-03-22 Smith & Nephew, Inc. Self contained wound dressing with micropump
US10201644B2 (en) 2005-09-07 2019-02-12 Smith & Nephew, Inc. Self contained wound dressing with micropump
US8162909B2 (en) 2005-09-15 2012-04-24 Smith & Nephew Plc Negative pressure wound treatment
US20090105671A1 (en) * 2005-11-25 2009-04-23 Daggar Anthony C Fibrous dressing
US20130023841A1 (en) * 2006-03-14 2013-01-24 Johnson Royce W System and method for percutaneously administering reduced pressure treatment using a flowable manifold
US20070218101A1 (en) * 2006-03-14 2007-09-20 Johnson Royce W System and method for percutaneously administering reduced pressure treatment using a flowable manifold
US8267918B2 (en) * 2006-03-14 2012-09-18 Kci Licensing, Inc. System and method for percutaneously administering reduced pressure treatment using a flowable manifold
US20070219489A1 (en) * 2006-03-14 2007-09-20 Johnson Royce W Method for percutaneously administering reduced pressure treatment using balloon dissection
US8771253B2 (en) * 2006-03-14 2014-07-08 Kci Licensing, Inc. System and method for percutaneously administering reduced pressure treatment using a flowable manifold
US9050402B2 (en) * 2006-03-14 2015-06-09 Kci Licensing, Inc. Method for percutaneously administering reduced pressure treatment using balloon dissection
US8460255B2 (en) 2006-05-11 2013-06-11 Kalypto Medical, Inc. Device and method for wound therapy
US7779625B2 (en) 2006-05-11 2010-08-24 Kalypto Medical, Inc. Device and method for wound therapy
US11517656B2 (en) 2006-05-11 2022-12-06 Smith & Nephew, Inc. Device and method for wound therapy
US7615036B2 (en) 2006-05-11 2009-11-10 Kalypto Medical, Inc. Device and method for wound therapy
US20070265586A1 (en) * 2006-05-11 2007-11-15 Joshi Ashok V Device and method for wound therapy
US20070265585A1 (en) * 2006-05-11 2007-11-15 Joshi Ashok V Device and method for wound therapy
US20100297208A1 (en) * 2006-05-12 2010-11-25 Nicholas Fry Scaffold
US8338402B2 (en) 2006-05-12 2012-12-25 Smith & Nephew Plc Scaffold
US20080015640A1 (en) * 2006-06-28 2008-01-17 Kaiser Daniel E Method for histogenesis and enhancement of tissue
US7931651B2 (en) 2006-11-17 2011-04-26 Wake Lake University Health Sciences External fixation assembly and method of use
US8454603B2 (en) * 2006-11-17 2013-06-04 Wake Forest University Health Sciences External fixation assembly and method of use
US9050136B2 (en) 2006-11-17 2015-06-09 Wake Forest University Health Sciences External fixation assembly and method of use
US20110202059A1 (en) * 2006-11-17 2011-08-18 Webb Lawrence X External fixation assembly and method of use
EP2106255A2 (en) * 2007-01-10 2009-10-07 Wake Forest University Health Sciences Apparatus and method for wound treatment employing periodic sub-atmospheric pressure
EP2106255B1 (en) 2007-01-10 2016-03-23 Wake Forest University Health Sciences Apparatus and method for wound treatment employing periodic sub-atmospheric pressure
US8377016B2 (en) 2007-01-10 2013-02-19 Wake Forest University Health Sciences Apparatus and method for wound treatment employing periodic sub-atmospheric pressure
EP2106255A4 (en) * 2007-01-10 2013-09-11 Univ Wake Forest Health Sciences Apparatus and method for wound treatment employing periodic sub-atmospheric pressure
US20080275409A1 (en) * 2007-05-01 2008-11-06 The Brigham And Women's Hospital, Inc. Wound healing device
US8057446B2 (en) 2007-05-01 2011-11-15 The Brigham And Women's Hospital, Inc. Wound healing device
WO2009006226A1 (en) * 2007-06-29 2009-01-08 Kci Licensing Inc. Activation of bone and cartilage formation
US8894620B2 (en) * 2007-06-29 2014-11-25 Kci Licensing, Inc. Activation of bone and cartilage formation
US8152783B2 (en) * 2007-06-29 2012-04-10 Kci Licensing, Inc. Activation of bone and cartilage formation
US20120165766A1 (en) * 2007-06-29 2012-06-28 Kci Licensing, Inc. Activation of bone and cartilage formation
US9271837B2 (en) 2007-06-29 2016-03-01 Kci Licensing, Inc. Activation of bone and cartilage formation
EP2160169A4 (en) * 2007-06-29 2017-07-05 KCI Licensing, Inc. Activation of bone and cartilage formation
AU2013231068B2 (en) * 2007-06-29 2015-11-12 Kci Licensing Inc. Activation of bone and cartilage formation
TWI392472B (en) * 2007-06-29 2013-04-11 Kci Licensing Inc Composition for activation of bone and cartilage formation
US8834520B2 (en) 2007-10-10 2014-09-16 Wake Forest University Devices and methods for treating spinal cord tissue
US8764732B2 (en) 2007-11-21 2014-07-01 Smith & Nephew Plc Wound dressing
US10123909B2 (en) 2007-11-21 2018-11-13 Smith & Nephew Plc Wound dressing
US11701266B2 (en) * 2007-11-21 2023-07-18 Smith & Nephew Plc Vacuum assisted wound dressing
US10744041B2 (en) 2007-11-21 2020-08-18 Smith & Nephew Plc Wound dressing
US11351064B2 (en) 2007-11-21 2022-06-07 Smith & Nephew Plc Wound dressing
US11045598B2 (en) * 2007-11-21 2021-06-29 Smith & Nephew Plc Vacuum assisted wound dressing
US10555839B2 (en) 2007-11-21 2020-02-11 Smith & Nephew Plc Wound dressing
US11110010B2 (en) 2007-11-21 2021-09-07 Smith & Nephew Plc Wound dressing
US11129751B2 (en) 2007-11-21 2021-09-28 Smith & Nephew Plc Wound dressing
US9844475B2 (en) 2007-11-21 2017-12-19 Smith & Nephew Plc Wound dressing
US20210322666A1 (en) * 2007-11-21 2021-10-21 Smith & Nephew Plc Vacuum assisted wound dressing
US10231875B2 (en) 2007-11-21 2019-03-19 Smith & Nephew Plc Wound dressing
US9220822B2 (en) 2007-11-21 2015-12-29 Smith & Nephew Plc Wound dressing
US20230338196A1 (en) * 2007-11-21 2023-10-26 Smith & Nephew Plc Vacuum assisted wound dressing
US11179276B2 (en) 2007-11-21 2021-11-23 Smith & Nephew Plc Wound dressing
US10016309B2 (en) 2007-11-21 2018-07-10 Smith & Nephew Plc Wound dressing
US8808274B2 (en) 2007-11-21 2014-08-19 Smith & Nephew Plc Wound dressing
US11364151B2 (en) 2007-11-21 2022-06-21 Smith & Nephew Plc Wound dressing
US8715256B2 (en) 2007-11-21 2014-05-06 Smith & Nephew Plc Vacuum assisted wound dressing
US9962474B2 (en) 2007-11-21 2018-05-08 Smith & Nephew Plc Vacuum assisted wound dressing
US9956121B2 (en) 2007-11-21 2018-05-01 Smith & Nephew Plc Wound dressing
US10299966B2 (en) 2007-12-24 2019-05-28 Kci Usa, Inc. Reinforced adhesive backing sheet
US8764794B2 (en) 2008-01-09 2014-07-01 Wake Forest University Health Sciences Device and method for treating central nervous system pathology
US8267960B2 (en) 2008-01-09 2012-09-18 Wake Forest University Health Sciences Device and method for treating central nervous system pathology
US10010656B2 (en) 2008-03-05 2018-07-03 Kci Licensing, Inc. Dressing and method for applying reduced pressure to and collecting and storing fluid from a tissue site
US11020516B2 (en) 2008-03-05 2021-06-01 Kci Licensing, Inc. Dressing and method for applying reduced pressure to and collecting and storing fluid from a tissue site
US9956329B2 (en) 2008-03-07 2018-05-01 Smith & Nephew, Inc. Wound dressing port and associated wound dressing
US9033942B2 (en) 2008-03-07 2015-05-19 Smith & Nephew, Inc. Wound dressing port and associated wound dressing
US20090299306A1 (en) * 2008-05-27 2009-12-03 John Buan Control unit with pump module for a negative pressure wound therapy device
US8197806B2 (en) 2008-06-26 2012-06-12 Kci Licensing, Inc Stimulation of cartilage formation using reduced pressure treatment
AU2009262163B2 (en) * 2008-06-26 2015-07-09 Kci Licensing, Inc. Stimulation of cartilage formation using reduced pressure treatment and chondrocytes
US8246948B2 (en) 2008-06-26 2012-08-21 Kci Licensing, Inc. Stimulation of cartilage formation using reduced pressure treatment
WO2009158480A3 (en) * 2008-06-26 2010-06-17 Kci Licensing, Inc. Stimulation of cartilage formation using reduced pressure treatment and chondrocytes
US20110218504A1 (en) * 2008-06-26 2011-09-08 Swain Larry D Stimulation of cartilage formation using reduced pressure treatment
WO2009158480A2 (en) * 2008-06-26 2009-12-30 Kci Licensing, Inc. Stimulation of cartilage formation using reduced pressure treatment
AU2009270900B2 (en) * 2008-07-18 2015-03-26 Wake Forest University Health Sciences Apparatus and method for cardiac tissue modulation by topical application of vacuum to minimize cell death and damage
WO2010009294A1 (en) * 2008-07-18 2010-01-21 Wake Forest University Heath Sciences Apparatus and method for cardiac tissue modulation by topical application of vacuum to minimize cell death and damage
RU2544093C2 (en) * 2008-07-18 2015-03-10 Уэйк Форест Юниверсити Хелс Сайенсиз Device and method for cardiac tissue modulation by local application of pressure below atmospheric for minimising cell death and injury
US10076318B2 (en) 2008-07-18 2018-09-18 Wake Forest University Health Sciences Apparatus and method for cardiac tissue modulation by topical application of vacuum to minimize cell death and damage
US9289193B2 (en) 2008-07-18 2016-03-22 Wake Forest University Health Sciences Apparatus and method for cardiac tissue modulation by topical application of vacuum to minimize cell death and damage
US20100042033A1 (en) * 2008-08-18 2010-02-18 Daron Carl Praetzel Tissue spacer for wound treatment employing reduced pressure and method and apparatus employing same
US7935858B2 (en) 2008-08-18 2011-05-03 Daron Carl Praetzel Tissue spacer for wound treatment employing reduced pressure and method and apparatus employing same
US20100168746A1 (en) * 2008-12-30 2010-07-01 Griffey Edward S Reduced pressure augmentation of microfracture procedures for cartilage repair
US8702711B2 (en) 2008-12-30 2014-04-22 Kci Licensing, Inc. Reduced pressure augmentation of microfracture procedures for cartilage repair
WO2010078118A3 (en) * 2008-12-30 2010-10-21 Kci Licensing, Inc. Reduced pressure augmentation of microfracture procedures for cartilage repair
US10155074B2 (en) 2008-12-31 2018-12-18 Kci Licensing, Inc. Tissue roll scaffolds
WO2010078342A2 (en) * 2008-12-31 2010-07-08 Kci Licensing Inc. System for providing fluid flow to nerve tissues
US8734474B2 (en) 2008-12-31 2014-05-27 Kci Licensing, Inc. System for providing fluid flow to nerve tissues
CN102333555A (en) * 2008-12-31 2012-01-25 凯希特许有限公司 Be used for manifold, the system and method for application of reduced pressure in the subcutaneous tissue position
WO2010078342A3 (en) * 2008-12-31 2010-10-21 Kci Licensing Inc. System for providing fluid flow to nerve tissues
AU2009335117B2 (en) * 2008-12-31 2015-08-20 Kci Licensing, Inc. System for providing fluid flow to nerve tissues
US8734409B2 (en) * 2008-12-31 2014-05-27 Kci Licensing, Inc. Systems for providing fluid flow to tissues
US20140276251A1 (en) * 2008-12-31 2014-09-18 Kci Licensing, Inc. Systems for providing fluid flow to tissues
EP2851098A1 (en) 2008-12-31 2015-03-25 KCI Licensing, Inc. Systems for inducing fluid flow to stimulate tissue growth
US9351882B2 (en) 2008-12-31 2016-05-31 Kci Licensing, Inc. System for providing fluid flow to nerve tissues
WO2010078345A3 (en) * 2008-12-31 2010-10-21 Kci Licensing, Inc. System for providing fluid flow to nerve tissues
US8257372B2 (en) 2008-12-31 2012-09-04 Kci Licensing, Inc. System for providing fluid flow to nerve tissues
EP2848268A1 (en) 2008-12-31 2015-03-18 KCI Licensing, Inc. Tissue roll scaffolds
WO2010078345A2 (en) * 2008-12-31 2010-07-08 Kci Licensing, Inc. System for providing fluid flow to nerve tissues
US9918880B2 (en) * 2008-12-31 2018-03-20 Kci Licensing, Inc. Systems for providing fluid flow to tissues
US20100168689A1 (en) * 2008-12-31 2010-07-01 Swain Larry D Systems for providing fluid flow to tissues
US9579431B2 (en) 2009-04-17 2017-02-28 Kalypto Medical, Inc. Negative pressure wound therapy device
US10111991B2 (en) 2009-04-17 2018-10-30 Smith & Nephew, Inc. Negative pressure wound therapy device
US8663198B2 (en) 2009-04-17 2014-03-04 Kalypto Medical, Inc. Negative pressure wound therapy device
US11058588B2 (en) 2009-12-22 2021-07-13 Smith & Nephew, Inc. Apparatuses and methods for negative pressure wound therapy
US10406037B2 (en) 2009-12-22 2019-09-10 Smith & Nephew, Inc. Apparatuses and methods for negative pressure wound therapy
US8814842B2 (en) * 2010-03-16 2014-08-26 Kci Licensing, Inc. Delivery-and-fluid-storage bridges for use with reduced-pressure systems
US11400204B2 (en) * 2010-03-16 2022-08-02 Kci Licensing, Inc. Delivery-and-fluid-storage bridges for use with reduced-pressure systems
US20110230849A1 (en) * 2010-03-16 2011-09-22 Richard Daniel John Coulthard Delivery-and-fluid-storage bridges for use with reduced-pressure systems
US20140330227A1 (en) * 2010-03-16 2014-11-06 Kci Licensing, Inc. Delivery-and-fluid-storage bridges for use with reduced-pressure systems
US10279088B2 (en) * 2010-03-16 2019-05-07 Kci Licensing, Inc. Delivery-and-fluid-storage bridges for use with reduced-pressure systems
US11058587B2 (en) 2010-04-27 2021-07-13 Smith & Nephew Plc Wound dressing and method of use
US10159604B2 (en) 2010-04-27 2018-12-25 Smith & Nephew Plc Wound dressing and method of use
US9061095B2 (en) 2010-04-27 2015-06-23 Smith & Nephew Plc Wound dressing and method of use
US11090195B2 (en) 2010-04-27 2021-08-17 Smith & Nephew Plc Wound dressing and method of use
US9808561B2 (en) 2010-04-27 2017-11-07 Smith & Nephew Plc Wound dressing and method of use
USRE48117E1 (en) 2010-05-07 2020-07-28 Smith & Nephew, Inc. Apparatuses and methods for negative pressure wound therapy
USD804014S1 (en) 2010-12-22 2017-11-28 Smith & Nephew, Inc. Suction adapter
US11247034B2 (en) 2010-12-22 2022-02-15 Smith & Nephew, Inc. Apparatuses and methods for negative pressure wound therapy
US10568767B2 (en) 2011-01-31 2020-02-25 Kci Usa, Inc. Silicone wound dressing laminate and method for making the same
US20120203144A1 (en) * 2011-02-07 2012-08-09 Kci Licensing, Inc. Methods and systems for treating a hoof on an ungulate mammal
US10357406B2 (en) 2011-04-15 2019-07-23 Kci Usa, Inc. Patterned silicone coating
US8945074B2 (en) 2011-05-24 2015-02-03 Kalypto Medical, Inc. Device with controller and pump modules for providing negative pressure for wound therapy
US9058634B2 (en) 2011-05-24 2015-06-16 Kalypto Medical, Inc. Method for providing a negative pressure wound therapy pump device
US10300178B2 (en) 2011-05-26 2019-05-28 Smith & Nephew, Inc. Method for providing negative pressure to a negative pressure wound therapy bandage
US9067003B2 (en) 2011-05-26 2015-06-30 Kalypto Medical, Inc. Method for providing negative pressure to a negative pressure wound therapy bandage
US20160374891A1 (en) * 2011-09-29 2016-12-29 Covidien Lp Compression garment having sealable bladder pocket
US10342730B2 (en) * 2011-09-29 2019-07-09 Kpr U.S., Llc Compression garment having sealable bladder pocket
US20130085427A1 (en) * 2011-09-29 2013-04-04 Tyco Healthcare Group Lp Compression garment having sealable bladder pocket
US9861532B2 (en) 2011-12-16 2018-01-09 Kci Licensing, Inc. Releasable medical drapes
US10940047B2 (en) 2011-12-16 2021-03-09 Kci Licensing, Inc. Sealing systems and methods employing a hybrid switchable drape
US10945889B2 (en) 2011-12-16 2021-03-16 Kci Licensing, Inc. Releasable medical drapes
US11090338B2 (en) 2012-07-13 2021-08-17 Lifecell Corporation Methods for improved treatment of adipose tissue
CN102805702A (en) * 2012-08-28 2012-12-05 广州赞德利医疗科技有限公司 Electrocardiograph synchronous female breast disease and breast enlargement negative pressure rehabilitation therapeutic apparatus
US9370536B2 (en) 2012-09-26 2016-06-21 Lifecell Corporation Processed adipose tissue
US10709810B2 (en) 2012-09-26 2020-07-14 Lifecell Corporation Processed adipose tissue
US11395785B2 (en) 2012-11-16 2022-07-26 Kci Licensing, Inc. Medical drape with pattern adhesive layers and method of manufacturing same
US11839529B2 (en) 2012-11-16 2023-12-12 Kci Licensing, Inc. Medical drape with pattern adhesive layers and method of manufacturing same
US10842707B2 (en) 2012-11-16 2020-11-24 Kci Licensing, Inc. Medical drape with pattern adhesive layers and method of manufacturing same
US9474883B2 (en) 2012-12-06 2016-10-25 Ic Surgical, Inc. Adaptable wound drainage system
US10271995B2 (en) 2012-12-18 2019-04-30 Kci Usa, Inc. Wound dressing with adhesive margin
US11141318B2 (en) 2012-12-18 2021-10-12 KCl USA, INC. Wound dressing with adhesive margin
US10117978B2 (en) 2013-08-26 2018-11-06 Kci Licensing, Inc. Dressing interface with moisture controlling feature and sealing function
US10946124B2 (en) 2013-10-28 2021-03-16 Kci Licensing, Inc. Hybrid sealing tape
US11744740B2 (en) 2013-10-30 2023-09-05 Kci Licensing, Inc. Dressing with sealing and retention interface
US9925092B2 (en) 2013-10-30 2018-03-27 Kci Licensing, Inc. Absorbent conduit and system
US10940046B2 (en) 2013-10-30 2021-03-09 Kci Licensing, Inc. Dressing with sealing and retention interface
US10016544B2 (en) 2013-10-30 2018-07-10 Kci Licensing, Inc. Dressing with differentially sized perforations
US11793923B2 (en) 2013-10-30 2023-10-24 Kci Licensing, Inc. Dressing with differentially sized perforations
US20150119831A1 (en) 2013-10-30 2015-04-30 Kci Licensing, Inc. Condensate absorbing and dissipating system
US9956120B2 (en) 2013-10-30 2018-05-01 Kci Licensing, Inc. Dressing with sealing and retention interface
US11154650B2 (en) 2013-10-30 2021-10-26 Kci Licensing, Inc. Condensate absorbing and dissipating system
US10849792B2 (en) 2013-10-30 2020-12-01 Kci Licensing, Inc. Absorbent conduit and system
US10398814B2 (en) 2013-10-30 2019-09-03 Kci Licensing, Inc. Condensate absorbing and dissipating system
US10967109B2 (en) 2013-10-30 2021-04-06 Kci Licensing, Inc. Dressing with differentially sized perforations
US10632020B2 (en) 2014-02-28 2020-04-28 Kci Licensing, Inc. Hybrid drape having a gel-coated perforated mesh
US11026844B2 (en) 2014-03-03 2021-06-08 Kci Licensing, Inc. Low profile flexible pressure transmission conduit
US10406266B2 (en) 2014-05-02 2019-09-10 Kci Licensing, Inc. Fluid storage devices, systems, and methods
US10561534B2 (en) 2014-06-05 2020-02-18 Kci Licensing, Inc. Dressing with fluid acquisition and distribution characteristics
US10398604B2 (en) 2014-12-17 2019-09-03 Kci Licensing, Inc. Dressing with offloading capability
US11246975B2 (en) 2015-05-08 2022-02-15 Kci Licensing, Inc. Low acuity dressing with integral pump
US11096830B2 (en) 2015-09-01 2021-08-24 Kci Licensing, Inc. Dressing with increased apposition force
US10973694B2 (en) 2015-09-17 2021-04-13 Kci Licensing, Inc. Hybrid silicone and acrylic adhesive cover for use with wound treatment
US11123375B2 (en) 2017-10-18 2021-09-21 Lifecell Corporation Methods of treating tissue voids following removal of implantable infusion ports using adipose tissue products
US10821205B2 (en) 2017-10-18 2020-11-03 Lifecell Corporation Adipose tissue products and methods of production
US11246994B2 (en) 2017-10-19 2022-02-15 Lifecell Corporation Methods for introduction of flowable acellular tissue matrix products into a hand
US11826488B2 (en) 2017-10-19 2023-11-28 Lifecell Corporation Flowable acellular tissue matrix products and methods of production
US11819386B2 (en) 2018-07-12 2023-11-21 T.J.Smith And Nephew, Limited Apparatuses and methods for negative pressure wound therapy
US11633521B2 (en) 2019-05-30 2023-04-25 Lifecell Corporation Biologic breast implant

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