US20030216769A1 - Removable anchored lung volume reduction devices and methods - Google Patents

Removable anchored lung volume reduction devices and methods Download PDF

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Publication number
US20030216769A1
US20030216769A1 US10/150,547 US15054702A US2003216769A1 US 20030216769 A1 US20030216769 A1 US 20030216769A1 US 15054702 A US15054702 A US 15054702A US 2003216769 A1 US2003216769 A1 US 2003216769A1
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US
United States
Prior art keywords
anchor
intra
air passageway
support structure
obstructing member
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US10/150,547
Inventor
David Dillard
Hugo Gonzalez
Seung Yi
Lauri DeVore
Mia Park
Dean Corcoran
Jenni Rimbaugh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gyrus ACMI Inc
Original Assignee
Spiration Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US10/150,547 priority Critical patent/US20030216769A1/en
Application filed by Spiration Inc filed Critical Spiration Inc
Assigned to SPIRATION, INC. reassignment SPIRATION, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: DILLARD, DAVID H., GONZALEZ, HUGO X., DEVORE, LAURI J., CORCORAN, DEAN T., PARK, MIA, RIMBAUGH, JENNI, YI, SEUNG
Priority to AU2003219927A priority patent/AU2003219927A1/en
Priority to CA002479805A priority patent/CA2479805A1/en
Priority to JP2003577779A priority patent/JP4387803B2/en
Priority to EP10196887.3A priority patent/EP2353557B1/en
Priority to EP03716212.0A priority patent/EP1494632B1/en
Priority to PCT/US2003/005968 priority patent/WO2003079944A1/en
Assigned to SPIRATION, INC. reassignment SPIRATION, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: ALFERNESS, CLIFTON A.
Publication of US20030216769A1 publication Critical patent/US20030216769A1/en
Priority to US10/744,577 priority patent/US7434578B2/en
Priority to US10/746,981 priority patent/US7842061B2/en
Priority to US10/933,778 priority patent/US7875048B2/en
Priority to US12/968,771 priority patent/US8257381B2/en
Priority to US13/554,987 priority patent/US8956319B2/en
Priority to US14/622,234 priority patent/US9358013B2/en
Assigned to GYRUS ACMI, INC. reassignment GYRUS ACMI, INC. MERGER (SEE DOCUMENT FOR DETAILS). Assignors: SPIRATION, INC.
Abandoned legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12099Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
    • A61B17/12104Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in an air passage
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12168Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure
    • A61B17/12172Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure having a pre-set deployed three-dimensional shape
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/24Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2476Valves implantable in the body not otherwise provided for
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00743Type of operation; Specification of treatment sites
    • A61B2017/00809Lung operations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/04Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2002/043Bronchi

Definitions

  • the present invention is generally directed to a removable anchored device, system, and method for treating Chronic Obstructive Pulmonary Disease (COPD).
  • COPD Chronic Obstructive Pulmonary Disease
  • the present invention is more particularly directed to providing an anchored intra-bronchial obstruction that may be removable.
  • COPD has become a major cause of morbidity and mortality in the United States over the last three decades.
  • COPD is characterized by the presence of airflow obstruction due to chronic bronchitis or emphysema.
  • the airflow obstruction in COPD is due largely to structural abnormalities in the smaller airways. Important causes are inflammation, fibrosis, goblet cell metaplasia, and smooth muscle hypertrophy in terminal bronchioles.
  • COPD chronic obstructive pulmonary disease
  • Pharmacotherapy may include bronchodilator therapy to open up the airways as much as possible or inhaled beta-agonists. For those patients who respond poorly to the foregoing or who have persistent symptoms, ipratropium bromide may be indicated. Further, courses of steroids, such as corticosteroids, may be required. Lastly, antibiotics may be required to prevent infections and influenza and pneumococcal vaccines may be routinely administered. Unfortunately, there is no evidence that early, regular use of pharmacotherapy will alter the progression of COPD.
  • lung transplantation is also an option.
  • COPD is the most common diagnosis for which lung transplantation is considered. Unfortunately, this consideration is given for only those with advanced COPD. Given the limited availability of donor organs, lung transplant is far from being available to all patients.
  • a promising new therapy includes non-surgical apparatus and procedures for lung volume reduction by permanently obstructing the air passageway that communicates with the portion of the lung to be collapsed.
  • the therapy includes placing an obstruction in the air passageway that prevents inhaled air from flowing into the portion of the lung to be collapsed. Lung volume reduction with concomitant improved pulmonary function may be obtained without the need for surgery.
  • the effectiveness of obstructions may be enhanced if it is anchored in place.
  • the effectiveness may also be enhanced if the obstruction is removable.
  • the present invention provides an anchored intra-bronchial device for placement in an air passageway of a patient to collapse a lung portion associated with the air passageway.
  • the device includes a support structure, an obstructing member carried by the support structure that prevents air from being inhaled into the lung portion to collapse the lung portion, and at least one anchor carried by the support structure that anchors the obstruction device within the air passageway when the anchor is deployed.
  • the support structure, or a portion thereof, may be collapsible.
  • the obstructing member and at least one anchor may be simultaneously deployable.
  • the support structure may be configured to urge at least one anchor to engage the air passageway wall.
  • the obstructing member may be a one-way valve.
  • the obstructing member may be releasable from the support structure and removable from the air passageway.
  • An anchor may have an anchoring end that engages the air passageway wall, and that may pierce into the air passageway wall.
  • An anchor may include a stop dimensioned for limiting the piercing of the air passageway wall.
  • An anchor may include a resilient material for imparting a force against the air passageway to deform the air passageway to more positively anchor the obstructing member.
  • An anchor may be releasable from the air passageway for removal of the intra-bronchial device.
  • An anchor may include a pad that frictionally engages the air passageway. Further, an anchor may be configured to move from a first configuration to a second configuration to engage the air passageway.
  • An anchor may be configured to move from a first configuration to a second configuration to engage the air passageway, and to move from the second configuration to the first configuration to disengage the air passageway.
  • an anchor may be configured to move from a first configuration to a second configuration to engage the air passageway, and to move from the second configuration to a third configuration to disengage the air passageway.
  • an anchor may be carried by a peripheral portion of the support structure, and/or by a central portion of the support structure.
  • An anchor may be carried distal to the obstructing member, and/or proximal to the obstructing member.
  • the present invention further provides a method of reducing the size of a lung, or reducing ventilation to a portion of a lung, by collapsing at least a portion of the lung.
  • the method includes the step of providing an intra-bronchial device that includes a support structure, an obstructing member carried by the support structure which is so dimensioned when deployed in an air passageway communicating with the portion of the lung to be collapsed to preclude air from being inhaled, and at least one anchor carried by the support structure that anchors the obstructing member when the anchor is deployed.
  • the method further includes the steps of placing the obstructing member in the air passageway, and deploying at least one anchor.
  • An anchor may be releasable for removal of the intra-bronchial device.
  • the obstructing member may form a one-way valve.
  • the support structure may be collapsible.
  • the present invention yet further provides a method of reducing the size of a lung, or reducing ventilation to a portion of a lung, by collapsing a portion of the lung with a removable device.
  • the method includes the step of providing an intra-bronchial device comprising a support structure, an obstructing member carried by the support structure which is so dimensioned when deployed in an air passageway communicating with the portion of the lung to be collapsed to preclude air from being inhaled, and at least one anchor carried by the support structure that anchors the obstructing member when the anchor is deployed.
  • the method further includes the steps of placing the obstructing member in the air passageway, and deploying at least one anchor.
  • the method further includes the step of removing at least the obstructing member.
  • At least one anchor may be releasable from the air passageway for removal of at least the obstructing device, and the step of removing at least the obstructing device includes releasing at least one anchor.
  • At least a portion of the obstructing member is releasable from the support structure, and the step of removing at least the obstructing member includes releasing the obstructing member from the support structure.
  • the obstructing member may form a one-way valve. At least a portion of the support structure may be collapsible.
  • the present invention additionally provides an air passageway obstructing device.
  • the device includes frame means for forming a support structure, flexible membrane means for obstructing air flow within the air passageway and carried by the support structure, and anchoring means to anchor the air passageway obstructing device, carried by the support structure.
  • the frame means is expandable to an expanded state within an air passageway to support the membrane means and the anchoring means.
  • the anchoring means is releasable for removal of the device from the air passageway.
  • FIG. 1 is a simplified sectional view of a thorax illustrating a healthy respiratory system
  • FIG. 2 is a sectional view similar to FIG. 1, but illustrating a respiratory system suffering from COPD and the execution of a first step in treating the COPD condition by reducing the size of a lung portion in accordance with the present invention
  • FIG. 3 is perspective view, partially in section, and to an enlarged scale, illustrating an intermediate step in the treatment
  • FIG. 4 is a perspective view of a conduit that may be utilized in practicing the present invention.
  • FIG. 5 is a perspective view of an intra-bronchial device, with anchors located proximally on peripheral portions of the support members, as the device would appear when fully deployed in an air passageway in accordance with the present invention
  • FIG. 6 is a partial section view of the device of FIG. 5 showing additional details of the support structure
  • FIG. 7 is a perspective view of the intra-bronchial device of FIG. 5 anchored in an air passageway;
  • FIG. 8 illustrates an intra-bronchial device, with anchors carried distally on the central support structure, fully deployed in an air passageway in accordance with an alternative embodiment of the invention
  • FIG. 9 is a perspective view of an intra-bronchial device, with proximal anchors carried on the central support structure, in accordance with an alternative embodiment of the invention.
  • FIG. 10 is a side view of an intra-bronchial device, with proximal anchors carried on the central support structure, in accordance with an alternative embodiment of the invention.
  • FIG. 11 is an end view of an intra-bronchial device, with proximal anchors carried on the central support structure, in accordance with an alternative embodiment of the invention
  • FIG. 12 is a perspective view of an intra-bronchial device, with distal friction anchors carried on the central support structure, in accordance with an alternative embodiment of the invention.
  • FIG. 13 is a side view of an intra-bronchial device, with distal friction anchors carried on the central support structure, in accordance with an alternative embodiment of the invention.
  • FIG. 14 is an end view of an intra-bronchial device, with distal friction anchors carried on the central support structure, in accordance with an alternative embodiment of the invention.
  • FIG. 15 is a perspective view of an intra-bronchial device similar to that of FIGS. 12 - 14 anchored in an air passageway;
  • FIG. 16 is a perspective view illustrating an alternative embodiment of a removable intra-bronchial device with proximal anchors carried on a peripheral portion of a plurality of support structure members in accord with the present invention
  • FIG. 17 is a side view of the device of FIG. 16;
  • FIG. 18 is a perspective view illustrating an alternative embodiment of a removable intra-bronchial device with both distal and proximal anchors carried on corresponding peripheral portions of the central support structure in accord with the present invention.
  • FIG. 19 is a side view of the device of FIG. 18.
  • proximal means nearest the trachea
  • distal means nearest the bronchioles
  • an aspect of the invention provides an anchored intra-bronchial device for placement in an air passageway of a patient.
  • the intra-bronchial device obstructs the air passageway, reducing the ventilation to a portion of the lung and/or collapsing the lung portion associated with the air passageway.
  • a further aspect of the invention provides removability of the intra-bronchial device, either by releasing the anchors for removal of the entire device or by separating the obstructing member and removing it.
  • FIG. 1 is a sectional view of a healthy respiratory system.
  • the respiratory system 20 resides within the thorax 22 that occupies a space defined by the chest wall 24 and the diaphragm 26 .
  • the respiratory system 20 includes the trachea 28 , the left mainstem bronchus 30 , the right mainstem bronchus 32 , the bronchial branches 34 , 36 , 38 , 40 , and 42 and sub-branches 44 , 46 , 48 , and 50 .
  • the respiratory system 20 further includes left lung lobes 52 and 54 and right lung lobes 56 , 58 , and 60 .
  • Each bronchial branch and sub-branch communicates with a respective different portion of a lung lobe, either the entire lung lobe or a portion thereof.
  • air passageway is meant to denote either a bronchi or bronchiole, and typically means a bronchial branch or sub-branch which communicates with a corresponding individual lung lobe or lung lobe portion to provide inhaled air thereto or conduct exhaled air therefrom.
  • Characteristic of a healthy respiratory system is the arched or inwardly arcuate diaphragm 26 .
  • the diaphragm 26 straightens to increase the volume of the thorax 22 . This causes a negative pressure within the thorax. The negative pressure within the thorax in turn causes the lung lobes to fill with air.
  • the diaphragm returns to its original arched condition to decrease the volume of the thorax. The decreased volume of the thorax causes a positive pressure within the thorax which in turn causes exhalation of the lung lobes.
  • FIG. 2 illustrates a respiratory system suffering from COPD.
  • the lung lobes 52 , 54 , 56 , 58 , and 60 are enlarged and that the diaphragm 26 is not arched but substantially straight.
  • this individual is incapable of breathing normally by moving diaphragm 26 .
  • this individual in order to create the negative pressure in thorax 22 required for breathing, this individual must move the chest wall outwardly to increase the volume of the thorax. This results in inefficient breathing causing these individuals to breathe rapidly with shallow breaths.
  • bronchial sub-branch obstructing devices are generally employed for treating the apex 66 of the right, upper lung lobe 56 .
  • the present invention may be applied to any lung portion without departing from the present invention.
  • the present invention may be used with any type of obstructing member to provide an anchored obstructing device, which may be removed.
  • the insertion of an obstructing member treats COPD by deriving the benefits of lung volume reduction surgery without the need of performing the surgery.
  • the treatment contemplates permanent collapse of a lung portion. This leaves extra volume within the thorax for the diaphragm to assume its arched state for acting upon the remaining healthier lung tissue. As previously mentioned, this should result in improved pulmonary function due to enhanced elastic recoil, correction of ventilation/perfusion mismatch, improved efficiency of respiratory musculature, and improved right ventricle filling.
  • the present invention supports the use of intra-bronchial obstructions to treat COPD by anchoring the obstruction device in the air passageway.
  • the present invention further supports the use of intra-bronchial obstructions by providing for their removal if necessary.
  • Use of anchors can allow the obstructing member to be relatively loosely fitted against the air passageway wall, which may preserve mucociliary transport of mucus and debris out of the collapsed lung portion and allow distal mucus to be coughed.
  • FIG. 2 also illustrates a step in COPD treatment using an obstructing member.
  • Treatment is initiated by feeding a conduit or catheter 70 down the trachea 28 , into the right mainstem bronchus 32 , into the bronchial branch 42 and into and terminating within the sub-branch 50 .
  • the sub-branch 50 is the air passageway that communicates with the lung portion 66 to be treated, and is also referred to herein as air passageway 50 .
  • the catheter 70 is preferably formed of flexible material such as polyethylene. Also, the catheter 70 is preferably preformed with a bend 72 to assist the feeding of the catheter from the right mainstem bronchus 32 into the bronchial branch 42 .
  • FIG. 3 illustrates a further step in a method for placing an obstructing member 90 in a bronchial sub-branch using a catheter.
  • Catheter 70 includes an optional inflatable sealing member 74 for use with a vacuum to collapse lung portion 66 prior to insertion of obstructing member 90 .
  • the obstructing member 90 may be formed of resilient or collapsible material to enable the obstructing member 90 to be fed through the conduit 70 in a collapsed state.
  • the stylet 92 is used to push the obstructing member 90 to the end 77 of the catheter 70 for placing the obstructing member 90 within the air passageway 50 adjacent to the lung portion 66 to be permanently collapsed.
  • Optional sealing member 74 is withdrawn after obstructing member 90 is inserted.
  • Another step in placing an obstructing member 90 may include sizing the air passageway location where the obstructing member 90 will be positioned.
  • a function of the intra-bronchial device disclosed and claimed in this specification, including the detailed description and the claims, is described in terms of collapsing a lung portion associated with an air passageway.
  • a portion of a lung may receive air from collateral air passageways. Obstructing one of the collateral air passageways may reduce the volume of the lung portion associated with the air passageway, but not completely collapse the lung portion, as that term may be generally understood.
  • the meaning of “collapse” includes both a complete collapse of a lung portion, and a partial collapse resulting in a marked decrease in the volume of a lung portion.
  • the obstructing member precludes inhaled air from entering the lung portion to be collapsed.
  • the obstructing member takes the form of a one-way valve.
  • the member further allows air within the lung portion to be exhaled. This results in more rapid collapse of the lung portion.
  • anchoring obstructing members that preclude both inhaled and exhaled airflow are contemplated as within the scope of the invention.
  • FIG. 4 illustrates the obstructing device in place within air passageway 50 .
  • Obstructing member 90 has expanded upon placement in the air passageway 50 to seal the air passageway 50 . This causes the lung portion 66 to be maintained in a permanently collapsed state.
  • the obstructing member 90 may be any shape suitable for accomplishing its purpose, and may be a solid material or a membrane.
  • the obstructing member 90 has an outer dimension 91 , and when expanded, enables a contact zone with the air passageway inner dimension 51 . This seals the air passageway upon placement of the obstructing member 90 in the air passageway 50 for maintaining the lung portion 66 in the collapsed state.
  • the lung portion 66 may be collapsed using vacuum prior to placement of obstructing member 90 , or sealing the air passageway 50 with obstructing member 90 may collapse it.
  • the air within the lung portion 66 will be absorbed by the body over time, reducing the volume of and/or collapsing the lung portion 66 .
  • obstructing member 90 may include the function of a one-way valve that allows air to escape from lung portion 66 . Lung portion 66 will then collapse, and the valve will prevent air from being inhaled.
  • FIG. 5 is a perspective view of an intra-bronchial device, with anchors located proximally on peripheral portions of the support members, as the device would appear when fully deployed in an air passageway in accordance with the present invention.
  • Intra-bronchial device 100 includes a support structure 101 , a central support structure 109 ; support members 102 , 104 , 106 , and 108 ; anchors 112 , 114 , 116 , and 118 ; anchor ends 122 , 124 , 126 , and 128 ; and an obstructing member 110 .
  • the support structure 101 of intra-bronchial device includes central support structure 109 , and support members 102 , 104 , 106 , and 108 .
  • the support members 102 , 104 , 106 , and 108 carry anchors 112 , 114 , 116 , and 118 ; and anchor ends 122 , 124 , 126 , and 128 , respectively.
  • Central support structure 109 is a tubular member, preferably hypodermic needle tubing.
  • Support members 102 , 104 , 106 , and 108 are coupled mechanically to central support structure 109 , such as by crimping, or by other methods such as adhesive or welding.
  • Support members 102 , 104 , 106 , and 108 are generally similar to each other.
  • the support members are preferably formed of stainless steel, Nitinol, or other suitable material having a memory of its original shape, and resiliency to return the material to that shape.
  • Anchors 112 , 114 , 116 , and 118 are extensions of support members 102 , 104 , 106 , and 108 .
  • the anchors are formed by bending the support members to an angle that will result in a deployed anchor engaging the air passageway wall by piercing it approximately perpendicularly. In this preferred embodiment, the bend angle is approximately a right angle.
  • Anchor ends 122 , 124 , 126 , and 128 may be shaped to promote piercing the air passageway wall.
  • the elements of support structure 101 may be formed by laser cutting a single piece of hypodermic needle tubing.
  • Obstructing member 110 is carried on the support structure 101 , and includes a flexible membrane open in the proximal direction and which may be formed of silicone or polyurethane, for example.
  • the obstructing member 110 is secured to the central support structure 109 , and may be additionally secured to the support members at its larger diameter 91 . It may be secured by adhesive, or other manner known in the art.
  • Obstructing member 110 may be loosely carried on support members 102 , 104 , 106 , and 108 , such that it expands on inhalation to form a seal against a wall of the air passageway, and contracts on exhalation to allow air and mucociliary transport from the collapsed lung. This provides a one-way valve function.
  • FIG. 6 is a partial section view of the device of FIG. 5 showing additional detail of the support structure.
  • the linear cross-section view of FIG. 6 exposes the arrangement of support members 106 and 108 in their deployed configuration.
  • the details of support members 102 and 104 are omitted from FIG. 6 for clarity, but are the same as support members 106 and 108 .
  • the distal end of obstructing member 110 is carried on central support structure 109 .
  • Support members 106 and 108 are shown emanating from central support structure 109 , and arranged to loosely support to obstructing member 110 at its larger diameter 91 . This allows obstructing member 110 to expand on inhalation and seal at the contact zone (element 129 of FIG.
  • support members 106 and 108 do not actively support obstructing member 110 , and the expansion and contraction of obstructing member 110 is governed by its elasticity.
  • FIG. 7 is a perspective view of the intra-bronchial device of FIG. 5 anchored in an air passageway.
  • Intra-bronchial device 100 is illustrated with anchors 112 and 116 piercing into the air passageway wall 130 of air passageway 50 . This anchors the intra-bronchial device 100 in place.
  • Intra-bronchial device 100 is collapsible for insertion into an internal lumen of a catheter. At least the support members 102 , 104 , 106 , and 108 , and the obstructing member 110 , may be collapsed. Intra-bronchial device 100 is inserted into the catheter lumen, which is typically already placed in the air passageway 50 as generally illustrated in FIG. 3. Using the stylet, intra-bronchial device 100 is advanced down the catheter lumen into the air passageway 50 to where the device is to be deployed. Once the point of deployment is reached, intra-bronchial device 100 is expelled from the catheter and assumes its deployed shape as illustrated in FIG. 5.
  • obstructing member 110 forms a contact zone 129 with the wall 130 of the air passageway 50 to prevent air from being inhaled into the lung portion to collapse the lung portion.
  • the memory and resiliency of the support members 102 , 104 , 106 , and 108 impart a force on the anchor ends 122 , 124 , 126 , and 128 , and urge the anchors 112 , 114 , 116 , and 118 to engage air passageway wall 130 by piercing.
  • the anchors pierce into and become embedded in the wall 130 of the air passageway 50 , preferably without projecting through the wall 130 . Stops may be incorporated into the anchors to limit piercing of the wall 130 .
  • the bend between the support member and the anchor may form a stop.
  • the preclusion of air from being inhaled into the lung portion may be terminated by eliminating the obstructing effect of intra-bronchial device 100 .
  • the preclusion of air by the embodiment illustrated in FIGS. 5 - 7 may be eliminated by releasing anchors 112 , 114 , 116 , and 118 from the air passageway wail 130 .
  • the anchors may be released by inserting a catheter into air passageway 50 in proximity to intra-bronchial device 100 .
  • a retractor device, such as biopsy forceps, capable of gripping a portion of intra-bronchial device 100 is inserted in the catheter.
  • the forceps are used to engage a portion of the support structure 101 of intra-bronchial device 100 , such as a support member or an anchor, or the obstructing member 110 , and draw it toward the catheter.
  • the drawing action releases anchors 112 , 114 , 116 , and 118 from air passageway wall 130 .
  • the intra-bronchial device 110 is then drawn into the catheter with the forceps, causing the support structure 101 and obstructing member 110 to collapse.
  • the collapsed device 100 now fully enters the catheter lumen for removal from the patient.
  • the obstructing effect may be eliminated by grabbing the obstructing member 110 , releasing it from the support structure 101 , and removing obstructing member 110 from the patient.
  • FIG. 8 illustrates an intra-bronchial device, with anchors carried distally on the central support structure, fully deployed in an air passageway in accordance with an alternative embodiment of the invention.
  • the anchors 112 , 114 , 116 , and 118 of intra-bronchial device 140 are carried on portions of support members 102 , 104 , 106 , and 108 distal of the central support structure 109 .
  • the support members are gathered together and carried by the central support structure 109 .
  • intra-bronchial device 140 is substantially similar in construction, operation, and removal as the intra-bronchial device 100 of FIG. 5.
  • the anchors 112 , 114 , 116 , and 118 are collapsed into a first configuration.
  • the anchor ends 122 , 124 , 126 , and 128 are moved toward obstructing member 110 , and anchors 112 , 114 , 116 , and 118 thereby folded toward obstructing member 110 .
  • the anchor ends 122 , 124 , 126 , and 128 are moved away from obstructing member 110 , and anchors 112 , 114 , 116 , and 118 thereby folded away from obstructing member 110 .
  • intra-bronchial device 100 When intra-bronchial device 100 is deployed from the catheter lumen, the memory and resiliency of the anchors 112 , 114 , 116 , and 118 impart a force that moves the anchor ends 122 , 124 , 126 , and 128 into a second configuration to engage air passageway wall 130 . This is the deployed configuration illustrated in FIG. 8.
  • drawing intra-bronchial device 140 toward the catheter causes the anchor ends 122 , 124 , 126 , and 128 to move away from obstructing member 110 to a third configuration.
  • Anchors 112 , 114 , 116 , and 118 are thereby folded away from obstructing member 110 and are released from engagement with air passageway wall 130 for removal of the intra-bronchial device 140 .
  • the anchors 112 , 114 , 116 , and 118 may be formed on additional support members carried by central support structure 109 , instead of being formed from distal portions of support members 102 , 104 , 106 , and 108 .
  • FIGS. 9 - 11 illustrate an intra-bronchial device, with proximal anchors carried on the central support structure, in accordance with an alternative embodiment of the invention.
  • FIG. 9 is a perspective view
  • FIG. 10 is a side view
  • FIG. 11 is an end view of the device.
  • Intra-bronchial device 150 is generally similar in construction, operation, placement, and removal to the intra-bronchial device 100 of FIG. 5. Its structure has six support members and three anchors, with anchor stops. Anchors 112 , 114 , and 116 include stops 152 , 154 , and 156 respectively.
  • Intra-bronchial device 150 also includes an anchor base 161 , an anchor base aperture 165 , anchor base angle 163 , and two additional support members 103 and 105 .
  • Central support structure 109 extends both proximal and distal of obstructing member 110 , and carries anchor base 161 proximal of obstructing member 110 , carries anchors 112 , 114 , and 116 , and includes anchor base aperture 165 .
  • the linear plane of anchors 112 , 114 , and 116 intersect anchor base 161 at anchor base angle 163 .
  • Anchor base angle 163 is selected to optimize anchor deployment force and anchor release.
  • Stops 152 , 154 , and 156 include a flat area to limit the piercing of the air passageway wall by anchor ends 122 , 124 , and 126 . In alternative embodiments, the stops can be any configuration or shape known to those skilled in the art to limit the piercing.
  • anchors 112 , 114 , and 116 are collapsed into a first configuration.
  • the anchor ends 122 , 124 , and 126 are moved toward obstructing member 110 , thereby decreasing anchor base angle 163 and folding anchors 112 , 114 , and 116 toward obstructing member 110 .
  • the anchor ends and the anchors may be moved by sliding a catheter or hollow member over anchor base 161 and toward obstructing member 110 .
  • the memory and resiliency of the anchors 112 , 114 , and 116 , anchor angle 163 , and anchor base 161 impart a force that moves the anchor members into a second configuration, which is the deployed configuration, to engage air passageway wall 130 .
  • the second or deployed configuration is illustrated in FIGS. 9 - 11 . Stops 152 , 154 , and 156 limit the piercing of the air passageway wall by anchor ends 122 , 124 , and 126 .
  • a retractor device is deployed from a catheter to engage anchor base 161 and restrain intra-bronchial device 150 .
  • Anchor base aperture 165 is arranged for being gripped by a retractor device.
  • the retractor device may be a biopsy forceps to engage anchor base 161 , or a hooked device to engage anchor base aperture 165 .
  • the retractor device is then used to draw intra-bronchial device 150 proximal, releasing the anchors 112 , 114 , and 116 from the air passageway wall. This collapses the anchors into to the first configuration for removal.
  • a catheter may then moved distally over anchor base 161 , and in contact with anchors 112 , 114 , and 116 .
  • the catheter is further moved against anchors 112 , 114 , and 116 , while intra-bronchial device 150 is restrained at anchor base 161 .
  • intra-bronchial device 150 is then further drawn into the catheter by pulling on the retractor device used to engage anchor base 161 . This collapses support structure 101 and obstructing member 110 so that they may be fully drawn into the catheter. Once drawn into the catheter, intra-bronchial device 160 may be removed from the air passageway and the patient.
  • FIGS. 12 - 14 illustrate an intra-bronchial device, with distal friction anchors carried on the central support structure, in accordance with an alternative embodiment of the invention.
  • FIG. 12 is a perspective view
  • FIG. 13 is a side view
  • FIG. 14 is an end view.
  • Intra-bronchial device 160 is generally similar in construction, placement, and operation to the intra-bronchial device 150 of FIGS. 9 - 11 .
  • Intra-bronchial device 160 is removed in the manner described in conjunction with FIG. 7.
  • Intra-bronchial device 160 differs from intra-bronchial device 150 in that the structure includes four distal anchors with anchor ends 122 , 124 , 126 , and 128 shaped into pads that deform and frictionally engage the air passageway wall to more positively anchor intra-bronchial device 160 without piercing.
  • the structure also includes an obstructing member support base 170 .
  • Central support structure 109 extends distal of obstructing member 110 , and carries anchor base 161 distal of obstructing member 110 .
  • Anchor base 161 carries anchors 112 , 114 , 116 , and 118 .
  • the linear plane of anchors 112 , 114 , 116 , and 118 intersects anchor base 161 at anchor angle 163 .
  • Anchor angle 163 is selected to optimize anchor deployment force and anchor release.
  • the anchors 112 , 114 , 116 , and 118 , and anchor base 161 may be constructed by laser cutting a single piece of hypodermic tubing lengthwise to form the anchors 112 , 114 , 116 , and 118 , and then bending the anchors to form anchor angle 163 .
  • Anchor base 161 is secured to central support structure 109 .
  • Support members 102 , 103 , 104 , 105 , 106 , and 108 , and the obstructing member support member base 170 may be constructed in a like manner.
  • Obstructing member 110 is secured to the obstructing member support base 170 , and alternatively to support members 102 , 103 , 104 , 105 , 106 , and 108 .
  • the assembly of obstructing member 110 and support base 170 is secured to central support structure 109 .
  • Central support structure 109 may extend proximal of support member base 170 to provide a surface for gripping the intra-bronchial device 160 for removal, and may include an aperture to be engaged by a hooked device.
  • FIG. 15 is a perspective view of an intra-bronchial device similar to that of FIGS. 12 - 14 anchored in an air passageway. It illustrates pad-shaped anchor ends 122 - 128 of intra-bronchial device 180 deforming and frictionally engaging air passageway wall 130 .
  • FIGS. 16 and 17 illustrate a removable intra-bronchial device with proximal anchors carried on a peripheral portion of a plurality of support structure members in accord with the present invention.
  • FIG. 16 is a perspective view, as the device would appear when fully deployed in an air passageway.
  • FIG. 17 is a side view of FIG. 16.
  • the support structure 101 of intra-bronchial device 190 includes six support members, with two opposing pairs of support members carrying anchors and each member of a pair being joined together by a retracting member.
  • Intra-bronchial device 190 includes a support structure 101 having a central support structure 109 and support members 102 , 103 , 104 , 105 , 106 , and 108 ; four anchors 113 , 114 , 116 , and 118 having anchor ends 123 , 124 , 126 , and 128 respectively; two “U” shaped retracting members 192 and 194 having an apex 193 and 195 respectively; and obstructing member 110 .
  • Intra-bronchial device 190 is generally similar in construction, operation, placement, and removal to the intra-bronchial device 150 of FIG. 9.
  • Support structure 101 is a tubular member, preferably hypodermic needle tubing, or stainless steel, Nitinol, or other suitable material having a memory of its original shape and resiliency to return the material to that shape.
  • Support members 102 , 103 , 104 , 105 , 106 , and 108 , and central support structure 109 may be formed by laser cutting a single piece of hypodermic needle tubing lengthwise, and bending the support members to a required shape.
  • Support members 102 , 103 , 104 , 105 , 106 , and 108 are generally similar to each other.
  • Anchors 113 , 114 , 116 , and 118 are disposed on support members 103 , 104 , 106 , and 108 , respectively, in any manner available in the art. Anchors 113 - 118 are disposed on support members 103 , 104 , 106 , and 108 to be located proximally of obstructing member 110 , and to engage an air passageway wall when intra-bronchial device 190 is deployed.
  • “U” shaped retracting member 192 is coupled to support members 103 and 104
  • “U” shaped retracting member 194 is coupled to support members 106 and 108
  • “U” shaped retracting members 192 and 194 may be constructed of any material suitable for use within a patient, and may or may not be resilient as required by the particular embodiment.
  • intra-bronchial device 190 When intra-bronchial device 190 is fully deployed in an air passageway, the “U” shaped retracting members 192 and 194 are arranged opposite each other, and they partially overlap, with the apex of one lying within a space bounded by the “U” shape of the other member. In the deployed configuration, increasing the distance between apex 193 and apex 195 moves support member pairs 103 - 104 and 106 - 108 centrally.
  • support members 102 , 103 , 104 , 105 , 106 , and 108 are collapsed centrally into a first configuration. This causes the anchor ends 123 , 124 , 126 and 128 to move centrally.
  • intra-bronchial device 190 When intra-bronchial device 190 is deployed from the catheter lumen, the memory and resiliency of the support member pairs 103 , 104 and 106 , 108 impart a force that moves the anchors 113 and 114 , and 116 and 118 , and their anchor ends 123 and 124 , and 126 and 128 into a second configuration, which is the deployed configuration to engage air passageway wall.
  • deployment of intra-bronchial device 190 may include a step of forcibly decreasing the distance between apexes 193 and 195 to forcibly move the anchors 113 and 114 , and 116 and 118 into engagement with the wall of the air passageway.
  • anchors 113 and 114 , and 116 and 118 of this embodiment do not include stops, the expansive or peripheral movement of the anchors will be limited by the interior surface of obstructing member 110 . This may limit the piercing of the air passageway wall by anchors 113 and 114 , and 116 and 118 .
  • support member pairs 103 , 104 and 106 , 108 may be compressed for insertion into a catheter lumen by a device that increases the distance between apex 193 and apex 195 .
  • a device that increases the distance between apex 193 and apex 195 .
  • Such a device could be a tool with spreading jaws, or a tapered member inserted between the apexes. The device could be left in engagement after insertion into the catheter, and then withdrawn to allow support member pairs 103 - 104 and 106 - 108 to move apart and engage their anchors into the wail of the air passageway.
  • a retractor device is deployed from a catheter lumen to engage apex 193 and 195 , and restrain intra-bronchial device 190 .
  • the retractor device may be any device that fits into the space defined by apexes 193 and 195 when the intra-bronchial device 190 is in its fully deployed configuration.
  • the retractor device is used to increase the distance between apexes 193 and 195 until anchors 113 , 114 , 116 , and 118 , and anchor ends 123 , 124 , 126 , and 128 are released from the air passageway wall. This collapses the anchors into to the first configuration for removal.
  • Intra-bronchial device 190 is then further collapsed, and drawn into the catheter by pulling on the retractor device. This additionally collapses support structure 101 and obstructing member 110 into the first position so that they may be fully drawn into the catheter. Once drawn into the catheter, intra-bronchial device 190 may be removed from the air passageway and the patient.
  • FIG. 18 is a perspective view illustrating an alternative embodiment of a removable intra-bronchial device 200 with both distal and proximal anchors carried on corresponding peripheral portions of central support structure 109 in accord with the present invention.
  • FIG. 19 is a side view of the device 200 of FIG. 18.
  • Intra-bronchial device 200 is generally similar in construction, placement, and operation to intra-bronchial device 150 of FIGS. 9 - 11 .
  • Intra-bronchial device 200 is removed in the manner described in conjunction with FIG. 7.
  • Intra-bronchial device 200 differs from intra-bronchial device 150 in that the central support structure 109 carries distal anchors in addition to the proximal anchors of device 150 .
  • Intra-bronchial device 200 includes distal anchors 212 , 213 , 214 , 216 , and 218 ; anchor ends 222 , 223 , 224 , 226 , and 228 ; and stops 252 , 253 , 254 , 256 , and 258 .
  • Intra-bronchial device 200 also include two more proximal anchors than device 150 , which are proximal anchors 113 and 118 ; anchor ends 123 and 128 , and stops 153 and 158 .
  • the central support structure 109 of support structure 101 extends both distally and proximally of obstructing member 110 , and carries both the proximal anchors 112 , 113 , 114 , 116 , and 118 and distal anchors 212 , 213 , 214 , 216 , and 218 .
  • the support structure 101 also includes support members 102 , 103 , 104 , 106 , and 108 . Because of the perspective of FIGS. 18 and 19, several of the anchor members and several of the support members are not visible. Intra-bronchial device 200 is expected to provide additional anchoring force compared to the other embodiments disclosed herein.

Abstract

An intra-bronchial device placed and anchored in an air passageway of a patient to collapse a lung portion associated with the air passageway. The device includes a support structure, an obstructing member carried by the support structure that reduces ventilation to the lung portion by preventing air from being inhaled into the lung portion, and at least one anchor carried by the support structure that anchors the obstruction device within the air passageway. The anchor may engage the air passageway wall by piercing or friction, include a stop dimensioned for limiting the piercing of the air passageway wall, and may be releasable from the air passageway for removal of the intra-bronchial device. The anchors may be carried by a peripheral portion of the support structure, or by a central portion of the support structure. The obstructing member may be a one-way valve.

Description

    BACKGROUND
  • The present invention is generally directed to a removable anchored device, system, and method for treating Chronic Obstructive Pulmonary Disease (COPD). The present invention is more particularly directed to providing an anchored intra-bronchial obstruction that may be removable. [0001]
  • COPD has become a major cause of morbidity and mortality in the United States over the last three decades. COPD is characterized by the presence of airflow obstruction due to chronic bronchitis or emphysema. The airflow obstruction in COPD is due largely to structural abnormalities in the smaller airways. Important causes are inflammation, fibrosis, goblet cell metaplasia, and smooth muscle hypertrophy in terminal bronchioles. [0002]
  • The incidence, prevalence, and health-related costs of COPD are on the rise. Mortality due to COPD is also on the rise. In 1991, COPD was the fourth leading cause of death in the United States and had increased 33% since 1979. COPD affects the patient's whole life. It has three main symptoms: cough; breathlessness; and wheeze. At first, breathlessness may be noticed when running for a bus, digging in the garden, or walking uphill. Later, it may be noticed when simply walking in the kitchen. Over time, it may occur with less and less effort until it is present all of the time. COPD is a progressive disease and currently has no cure. Current treatments for COPD include the prevention of further respiratory damage, pharmacotherapy, and surgery. Each is discussed below. [0003]
  • The prevention of further respiratory damage entails the adoption of a healthy lifestyle. Smoking cessation is believed to be the single most important therapeutic intervention. However, regular exercise and weight control are also important. Patients whose symptoms restrict their daily activities or who otherwise have an impaired quality of life may require a pulmonary rehabilitation program including ventilatory muscle training and breathing retraining. Long-term oxygen therapy may also become necessary. [0004]
  • Pharmacotherapy may include bronchodilator therapy to open up the airways as much as possible or inhaled beta-agonists. For those patients who respond poorly to the foregoing or who have persistent symptoms, ipratropium bromide may be indicated. Further, courses of steroids, such as corticosteroids, may be required. Lastly, antibiotics may be required to prevent infections and influenza and pneumococcal vaccines may be routinely administered. Unfortunately, there is no evidence that early, regular use of pharmacotherapy will alter the progression of COPD. [0005]
  • About 40 years ago, it was first postulated that the tethering force that tends to keep the intrathoracic airways open was lost in emphysema and that by surgically removing the most affected parts of the lungs, the force could be partially restored. Although the surgery was deemed promising, the lung volume reduction surgery (LVRS) procedure was abandoned. LVRS was later revived. In the early 1990's, hundreds of patients underwent the procedure. However, the procedure fell out of favor when Medicare stopped reimbursing for LVRS. Unfortunately, data is relatively scarce and many factors conspire to make what data exists difficult to interpret. The procedure is currently under review in a controlled clinical trial. However, what data does exist tends to indicate that patients benefited from the procedure in terms of an increase in forced expiratory volume, a decrease in total lung capacity, and a significant improvement in lung function, dyspnea, and quality of life. Improvements in pulmonary function after LVRS have been attributed to at least four possible mechanisms. These include enhanced elastic recoil, correction of ventilation/perfusion mismatch, improved efficiency of respiratory musculature, and improved right ventricular filling. [0006]
  • Lastly, lung transplantation is also an option. Today, COPD is the most common diagnosis for which lung transplantation is considered. Unfortunately, this consideration is given for only those with advanced COPD. Given the limited availability of donor organs, lung transplant is far from being available to all patients. [0007]
  • There is a need for additional non-surgical options for permanently treating COPD. A promising new therapy includes non-surgical apparatus and procedures for lung volume reduction by permanently obstructing the air passageway that communicates with the portion of the lung to be collapsed. The therapy includes placing an obstruction in the air passageway that prevents inhaled air from flowing into the portion of the lung to be collapsed. Lung volume reduction with concomitant improved pulmonary function may be obtained without the need for surgery. The effectiveness of obstructions may be enhanced if it is anchored in place. The effectiveness may also be enhanced if the obstruction is removable. However, no readily available apparatus and method exists for anchoring the obstruction, and for removal if required. [0008]
  • In view of the foregoing, there is a need in the art for a new and improved apparatus and method for permanently obstructing an air passageway that is anchored in place, and that may be removed if required. The present invention is directed to a device, system, and method that provide such an improved apparatus and method for treating COPD. [0009]
  • SUMMARY
  • The present invention provides an anchored intra-bronchial device for placement in an air passageway of a patient to collapse a lung portion associated with the air passageway. The device includes a support structure, an obstructing member carried by the support structure that prevents air from being inhaled into the lung portion to collapse the lung portion, and at least one anchor carried by the support structure that anchors the obstruction device within the air passageway when the anchor is deployed. The support structure, or a portion thereof, may be collapsible. The obstructing member and at least one anchor may be simultaneously deployable. The support structure may be configured to urge at least one anchor to engage the air passageway wall. The obstructing member may be a one-way valve. The obstructing member may be releasable from the support structure and removable from the air passageway. [0010]
  • In accordance with the present invention, alternative embodiments are provided for the anchors. An anchor may have an anchoring end that engages the air passageway wall, and that may pierce into the air passageway wall. An anchor may include a stop dimensioned for limiting the piercing of the air passageway wall. An anchor may include a resilient material for imparting a force against the air passageway to deform the air passageway to more positively anchor the obstructing member. An anchor may be releasable from the air passageway for removal of the intra-bronchial device. An anchor may include a pad that frictionally engages the air passageway. Further, an anchor may be configured to move from a first configuration to a second configuration to engage the air passageway. An anchor may be configured to move from a first configuration to a second configuration to engage the air passageway, and to move from the second configuration to the first configuration to disengage the air passageway. Alternatively, an anchor may be configured to move from a first configuration to a second configuration to engage the air passageway, and to move from the second configuration to a third configuration to disengage the air passageway. [0011]
  • In accordance with the present invention, alternative embodiments provide for the anchors to be carried on different portions of the device. An anchor may be carried by a peripheral portion of the support structure, and/or by a central portion of the support structure. An anchor may be carried distal to the obstructing member, and/or proximal to the obstructing member. [0012]
  • The present invention further provides a method of reducing the size of a lung, or reducing ventilation to a portion of a lung, by collapsing at least a portion of the lung. The method includes the step of providing an intra-bronchial device that includes a support structure, an obstructing member carried by the support structure which is so dimensioned when deployed in an air passageway communicating with the portion of the lung to be collapsed to preclude air from being inhaled, and at least one anchor carried by the support structure that anchors the obstructing member when the anchor is deployed. The method further includes the steps of placing the obstructing member in the air passageway, and deploying at least one anchor. An anchor may be releasable for removal of the intra-bronchial device. The obstructing member may form a one-way valve. The support structure may be collapsible. [0013]
  • The present invention yet further provides a method of reducing the size of a lung, or reducing ventilation to a portion of a lung, by collapsing a portion of the lung with a removable device. The method includes the step of providing an intra-bronchial device comprising a support structure, an obstructing member carried by the support structure which is so dimensioned when deployed in an air passageway communicating with the portion of the lung to be collapsed to preclude air from being inhaled, and at least one anchor carried by the support structure that anchors the obstructing member when the anchor is deployed. The method further includes the steps of placing the obstructing member in the air passageway, and deploying at least one anchor. The method further includes the step of removing at least the obstructing member. At least one anchor may be releasable from the air passageway for removal of at least the obstructing device, and the step of removing at least the obstructing device includes releasing at least one anchor. At least a portion of the obstructing member is releasable from the support structure, and the step of removing at least the obstructing member includes releasing the obstructing member from the support structure. The obstructing member may form a one-way valve. At least a portion of the support structure may be collapsible. [0014]
  • The present invention additionally provides an air passageway obstructing device. The device includes frame means for forming a support structure, flexible membrane means for obstructing air flow within the air passageway and carried by the support structure, and anchoring means to anchor the air passageway obstructing device, carried by the support structure. The frame means is expandable to an expanded state within an air passageway to support the membrane means and the anchoring means. The anchoring means is releasable for removal of the device from the air passageway. [0015]
  • These and various other features as well as advantages which characterize the present invention will be apparent from a reading of the following detailed description and a review of the associated drawings.[0016]
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • The features of the present invention which are believed to be novel are set forth with particularity in the appended claims. The invention, together with further objects and advantages thereof, may best be understood by making reference to the following description taken in conjunction with the accompanying drawings, in the several figures of which like referenced numerals identify like elements, and wherein: [0017]
  • FIG. 1 is a simplified sectional view of a thorax illustrating a healthy respiratory system; [0018]
  • FIG. 2 is a sectional view similar to FIG. 1, but illustrating a respiratory system suffering from COPD and the execution of a first step in treating the COPD condition by reducing the size of a lung portion in accordance with the present invention; [0019]
  • FIG. 3 is perspective view, partially in section, and to an enlarged scale, illustrating an intermediate step in the treatment; [0020]
  • FIG. 4 is a perspective view of a conduit that may be utilized in practicing the present invention; [0021]
  • FIG. 5 is a perspective view of an intra-bronchial device, with anchors located proximally on peripheral portions of the support members, as the device would appear when fully deployed in an air passageway in accordance with the present invention; [0022]
  • FIG. 6 is a partial section view of the device of FIG. 5 showing additional details of the support structure; [0023]
  • FIG. 7 is a perspective view of the intra-bronchial device of FIG. 5 anchored in an air passageway; [0024]
  • FIG. 8 illustrates an intra-bronchial device, with anchors carried distally on the central support structure, fully deployed in an air passageway in accordance with an alternative embodiment of the invention; [0025]
  • FIG. 9 is a perspective view of an intra-bronchial device, with proximal anchors carried on the central support structure, in accordance with an alternative embodiment of the invention; [0026]
  • FIG. 10 is a side view of an intra-bronchial device, with proximal anchors carried on the central support structure, in accordance with an alternative embodiment of the invention; [0027]
  • FIG. 11 is an end view of an intra-bronchial device, with proximal anchors carried on the central support structure, in accordance with an alternative embodiment of the invention; [0028]
  • FIG. 12 is a perspective view of an intra-bronchial device, with distal friction anchors carried on the central support structure, in accordance with an alternative embodiment of the invention; [0029]
  • FIG. 13 is a side view of an intra-bronchial device, with distal friction anchors carried on the central support structure, in accordance with an alternative embodiment of the invention; [0030]
  • FIG. 14 is an end view of an intra-bronchial device, with distal friction anchors carried on the central support structure, in accordance with an alternative embodiment of the invention; [0031]
  • FIG. 15 is a perspective view of an intra-bronchial device similar to that of FIGS. [0032] 12-14 anchored in an air passageway;
  • FIG. 16 is a perspective view illustrating an alternative embodiment of a removable intra-bronchial device with proximal anchors carried on a peripheral portion of a plurality of support structure members in accord with the present invention; [0033]
  • FIG. 17 is a side view of the device of FIG. 16; [0034]
  • FIG. 18 is a perspective view illustrating an alternative embodiment of a removable intra-bronchial device with both distal and proximal anchors carried on corresponding peripheral portions of the central support structure in accord with the present invention; and [0035]
  • FIG. 19 is a side view of the device of FIG. 18.[0036]
  • DETAILED DESCRIPTION
  • In the following detailed description of exemplary embodiments of the invention, reference is made to the accompanying drawings that form a part hereof. The detailed description and the drawings illustrate how specific exemplary embodiments by which the invention may be practiced. These embodiments are described in sufficient detail to enable those skilled in the art to practice the invention. It is understood that other embodiments may be utilized, and other changes may be made, without departing from the spirit or scope of the present invention. The following detailed description is therefore not to be taken in a limiting sense, and the scope of the present invention is defined by the appended claims. [0037]
  • Throughout the specification and claims, the following terms take the meanings explicitly associated herein unless the context clearly dictates otherwise. The meaning of “a”, “an”, and “the” include plural references. The meaning of “in” includes “in” and “on.” Referring to the drawings, like numbers indicate like parts throughout the views. Additionally, a reference to the singular includes a reference to the plural unless otherwise stated or inconsistent with the disclosure herein. [0038]
  • Additionally, throughout the specification, claims, and drawings, the term “proximal” means nearest the trachea, and “distal” means nearest the bronchioles. [0039]
  • Briefly stated, an aspect of the invention provides an anchored intra-bronchial device for placement in an air passageway of a patient. The intra-bronchial device obstructs the air passageway, reducing the ventilation to a portion of the lung and/or collapsing the lung portion associated with the air passageway. A further aspect of the invention provides removability of the intra-bronchial device, either by releasing the anchors for removal of the entire device or by separating the obstructing member and removing it. [0040]
  • FIG. 1 is a sectional view of a healthy respiratory system. The [0041] respiratory system 20 resides within the thorax 22 that occupies a space defined by the chest wall 24 and the diaphragm 26.
  • The [0042] respiratory system 20 includes the trachea 28, the left mainstem bronchus 30, the right mainstem bronchus 32, the bronchial branches 34, 36, 38, 40, and 42 and sub-branches 44, 46, 48, and 50. The respiratory system 20 further includes left lung lobes 52 and 54 and right lung lobes 56, 58, and 60. Each bronchial branch and sub-branch communicates with a respective different portion of a lung lobe, either the entire lung lobe or a portion thereof. As used herein, the term “air passageway” is meant to denote either a bronchi or bronchiole, and typically means a bronchial branch or sub-branch which communicates with a corresponding individual lung lobe or lung lobe portion to provide inhaled air thereto or conduct exhaled air therefrom.
  • Characteristic of a healthy respiratory system is the arched or inwardly [0043] arcuate diaphragm 26. As the individual inhales, the diaphragm 26 straightens to increase the volume of the thorax 22. This causes a negative pressure within the thorax. The negative pressure within the thorax in turn causes the lung lobes to fill with air. When the individual exhales, the diaphragm returns to its original arched condition to decrease the volume of the thorax. The decreased volume of the thorax causes a positive pressure within the thorax which in turn causes exhalation of the lung lobes.
  • In contrast to the healthy respiratory system of FIG. 1, FIG. 2 illustrates a respiratory system suffering from COPD. Here it may be seen that the [0044] lung lobes 52, 54, 56, 58, and 60 are enlarged and that the diaphragm 26 is not arched but substantially straight. Hence, this individual is incapable of breathing normally by moving diaphragm 26. Instead, in order to create the negative pressure in thorax 22 required for breathing, this individual must move the chest wall outwardly to increase the volume of the thorax. This results in inefficient breathing causing these individuals to breathe rapidly with shallow breaths.
  • It has been found that the [0045] apex portions 62 and 66 of the upper lung lobes 52 and 56, respectively, are most affected by COPD. Hence, bronchial sub-branch obstructing devices are generally employed for treating the apex 66 of the right, upper lung lobe 56. However, as will be appreciated by those skilled in the art, the present invention may be applied to any lung portion without departing from the present invention. As will be further appreciated by those skilled the in art, the present invention may be used with any type of obstructing member to provide an anchored obstructing device, which may be removed. The inventions disclosed and claimed in U.S. Pat. Nos. 6,258,100 and 6,293,951, both of which are incorporated herein by reference, provide an improved therapy for treating COPD by obstructing an air passageway using an intra-bronchial valve or plug. The present invention may be used with the apparatus, system, and methods of these patents as will be briefly described in conjunction with the disclosure of the preferred embodiments of the present invention.
  • The insertion of an obstructing member treats COPD by deriving the benefits of lung volume reduction surgery without the need of performing the surgery. The treatment contemplates permanent collapse of a lung portion. This leaves extra volume within the thorax for the diaphragm to assume its arched state for acting upon the remaining healthier lung tissue. As previously mentioned, this should result in improved pulmonary function due to enhanced elastic recoil, correction of ventilation/perfusion mismatch, improved efficiency of respiratory musculature, and improved right ventricle filling., The present invention supports the use of intra-bronchial obstructions to treat COPD by anchoring the obstruction device in the air passageway. The present invention further supports the use of intra-bronchial obstructions by providing for their removal if necessary. Use of anchors can allow the obstructing member to be relatively loosely fitted against the air passageway wall, which may preserve mucociliary transport of mucus and debris out of the collapsed lung portion and allow distal mucus to be coughed. [0046]
  • FIG. 2 also illustrates a step in COPD treatment using an obstructing member. Treatment is initiated by feeding a conduit or [0047] catheter 70 down the trachea 28, into the right mainstem bronchus 32, into the bronchial branch 42 and into and terminating within the sub-branch 50. The sub-branch 50 is the air passageway that communicates with the lung portion 66 to be treated, and is also referred to herein as air passageway 50. The catheter 70 is preferably formed of flexible material such as polyethylene. Also, the catheter 70 is preferably preformed with a bend 72 to assist the feeding of the catheter from the right mainstem bronchus 32 into the bronchial branch 42.
  • FIG. 3 illustrates a further step in a method for placing an obstructing [0048] member 90 in a bronchial sub-branch using a catheter. The invention disclosed herein is not limited to use with the particular method illustrated herein. Catheter 70 includes an optional inflatable sealing member 74 for use with a vacuum to collapse lung portion 66 prior to insertion of obstructing member 90. The obstructing member 90 may be formed of resilient or collapsible material to enable the obstructing member 90 to be fed through the conduit 70 in a collapsed state. The stylet 92 is used to push the obstructing member 90 to the end 77 of the catheter 70 for placing the obstructing member 90 within the air passageway 50 adjacent to the lung portion 66 to be permanently collapsed. Optional sealing member 74 is withdrawn after obstructing member 90 is inserted.
  • Another step in placing an obstructing [0049] member 90 may include sizing the air passageway location where the obstructing member 90 will be positioned.
  • A function of the intra-bronchial device disclosed and claimed in this specification, including the detailed description and the claims, is described in terms of collapsing a lung portion associated with an air passageway. In some lungs, a portion of a lung may receive air from collateral air passageways. Obstructing one of the collateral air passageways may reduce the volume of the lung portion associated with the air passageway, but not completely collapse the lung portion, as that term may be generally understood. As used herein, the meaning of “collapse” includes both a complete collapse of a lung portion, and a partial collapse resulting in a marked decrease in the volume of a lung portion. [0050]
  • Once deployed, the obstructing member precludes inhaled air from entering the lung portion to be collapsed. In accordance with the present invention, it is preferable that the obstructing member takes the form of a one-way valve. In addition to precluding inhaled air from entering the lung portion, the member further allows air within the lung portion to be exhaled. This results in more rapid collapse of the lung portion. In addition, anchoring obstructing members that preclude both inhaled and exhaled airflow are contemplated as within the scope of the invention. [0051]
  • FIG. 4 illustrates the obstructing device in place within [0052] air passageway 50. Obstructing member 90 has expanded upon placement in the air passageway 50 to seal the air passageway 50. This causes the lung portion 66 to be maintained in a permanently collapsed state. The obstructing member 90 may be any shape suitable for accomplishing its purpose, and may be a solid material or a membrane.
  • More specifically, the obstructing [0053] member 90 has an outer dimension 91, and when expanded, enables a contact zone with the air passageway inner dimension 51. This seals the air passageway upon placement of the obstructing member 90 in the air passageway 50 for maintaining the lung portion 66 in the collapsed state.
  • Alternatively, the [0054] lung portion 66 may be collapsed using vacuum prior to placement of obstructing member 90, or sealing the air passageway 50 with obstructing member 90 may collapse it. The air within the lung portion 66 will be absorbed by the body over time, reducing the volume of and/or collapsing the lung portion 66. Alternatively, obstructing member 90 may include the function of a one-way valve that allows air to escape from lung portion 66. Lung portion 66 will then collapse, and the valve will prevent air from being inhaled.
  • FIG. 5 is a perspective view of an intra-bronchial device, with anchors located proximally on peripheral portions of the support members, as the device would appear when fully deployed in an air passageway in accordance with the present invention. [0055] Intra-bronchial device 100 includes a support structure 101, a central support structure 109; support members 102, 104, 106, and 108; anchors 112, 114, 116, and 118; anchor ends 122, 124, 126, and 128; and an obstructing member 110.
  • The [0056] support structure 101 of intra-bronchial device includes central support structure 109, and support members 102, 104, 106, and 108. The support members 102, 104, 106, and 108, carry anchors 112, 114, 116, and 118; and anchor ends 122, 124, 126, and 128, respectively. Central support structure 109 is a tubular member, preferably hypodermic needle tubing. Support members 102, 104, 106, and 108, are coupled mechanically to central support structure 109, such as by crimping, or by other methods such as adhesive or welding. Support members 102, 104, 106, and 108 are generally similar to each other. The support members are preferably formed of stainless steel, Nitinol, or other suitable material having a memory of its original shape, and resiliency to return the material to that shape.
  • [0057] Anchors 112, 114, 116, and 118 are extensions of support members 102, 104, 106, and 108. The anchors are formed by bending the support members to an angle that will result in a deployed anchor engaging the air passageway wall by piercing it approximately perpendicularly. In this preferred embodiment, the bend angle is approximately a right angle. Anchor ends 122, 124, 126, and 128 may be shaped to promote piercing the air passageway wall. In an alternative embodiment, the elements of support structure 101 may be formed by laser cutting a single piece of hypodermic needle tubing.
  • Obstructing [0058] member 110 is carried on the support structure 101, and includes a flexible membrane open in the proximal direction and which may be formed of silicone or polyurethane, for example. The obstructing member 110 is secured to the central support structure 109, and may be additionally secured to the support members at its larger diameter 91. It may be secured by adhesive, or other manner known in the art. Obstructing member 110 may be loosely carried on support members 102, 104, 106, and 108, such that it expands on inhalation to form a seal against a wall of the air passageway, and contracts on exhalation to allow air and mucociliary transport from the collapsed lung. This provides a one-way valve function.
  • FIG. 6 is a partial section view of the device of FIG. 5 showing additional detail of the support structure. The linear cross-section view of FIG. 6 exposes the arrangement of [0059] support members 106 and 108 in their deployed configuration. The details of support members 102 and 104 are omitted from FIG. 6 for clarity, but are the same as support members 106 and 108. The distal end of obstructing member 110 is carried on central support structure 109. Support members 106 and 108 are shown emanating from central support structure 109, and arranged to loosely support to obstructing member 110 at its larger diameter 91. This allows obstructing member 110 to expand on inhalation and seal at the contact zone (element 129 of FIG. 7), and to partially contract on exhalation to allow exhalation of air and mucociliary transport. In an alternative embodiment, support members 106 and 108 do not actively support obstructing member 110, and the expansion and contraction of obstructing member 110 is governed by its elasticity.
  • FIG. 7 is a perspective view of the intra-bronchial device of FIG. 5 anchored in an air passageway. [0060] Intra-bronchial device 100 is illustrated with anchors 112 and 116 piercing into the air passageway wall 130 of air passageway 50. This anchors the intra-bronchial device 100 in place.
  • [0061] Intra-bronchial device 100 is collapsible for insertion into an internal lumen of a catheter. At least the support members 102, 104, 106, and 108, and the obstructing member 110, may be collapsed. Intra-bronchial device 100 is inserted into the catheter lumen, which is typically already placed in the air passageway 50 as generally illustrated in FIG. 3. Using the stylet, intra-bronchial device 100 is advanced down the catheter lumen into the air passageway 50 to where the device is to be deployed. Once the point of deployment is reached, intra-bronchial device 100 is expelled from the catheter and assumes its deployed shape as illustrated in FIG. 5. Upon deployment, obstructing member 110 forms a contact zone 129 with the wall 130 of the air passageway 50 to prevent air from being inhaled into the lung portion to collapse the lung portion. Simultaneously upon deployment, the memory and resiliency of the support members 102, 104, 106, and 108 impart a force on the anchor ends 122, 124, 126, and 128, and urge the anchors 112, 114, 116, and 118 to engage air passageway wall 130 by piercing. The anchors pierce into and become embedded in the wall 130 of the air passageway 50, preferably without projecting through the wall 130. Stops may be incorporated into the anchors to limit piercing of the wall 130. For example, the bend between the support member and the anchor may form a stop.
  • The preclusion of air from being inhaled into the lung portion may be terminated by eliminating the obstructing effect of [0062] intra-bronchial device 100. The preclusion of air by the embodiment illustrated in FIGS. 5-7 may be eliminated by releasing anchors 112, 114, 116, and 118 from the air passageway wail 130. The anchors may be released by inserting a catheter into air passageway 50 in proximity to intra-bronchial device 100. A retractor device, such as biopsy forceps, capable of gripping a portion of intra-bronchial device 100 is inserted in the catheter. The forceps are used to engage a portion of the support structure 101 of intra-bronchial device 100, such as a support member or an anchor, or the obstructing member 110, and draw it toward the catheter. The drawing action releases anchors 112, 114, 116, and 118 from air passageway wall 130. The intra-bronchial device 110 is then drawn into the catheter with the forceps, causing the support structure 101 and obstructing member 110 to collapse. The collapsed device 100 now fully enters the catheter lumen for removal from the patient. Alternatively, the obstructing effect may be eliminated by grabbing the obstructing member 110, releasing it from the support structure 101, and removing obstructing member 110 from the patient.
  • FIG. 8 illustrates an intra-bronchial device, with anchors carried distally on the central support structure, fully deployed in an air passageway in accordance with an alternative embodiment of the invention. The [0063] anchors 112, 114, 116, and 118 of intra-bronchial device 140 are carried on portions of support members 102, 104, 106, and 108 distal of the central support structure 109. The support members are gathered together and carried by the central support structure 109. Other than the anchors 112, 114, 116, and 118 being formed and carried on distal portions of support members 102, 104, 106, and 108, intra-bronchial device 140 is substantially similar in construction, operation, and removal as the intra-bronchial device 100 of FIG. 5.
  • When [0064] intra-bronchial device 140 is compressed for insertion into the catheter lumen for placement in the air passageway, the anchors 112, 114, 116, and 118 are collapsed into a first configuration. In the first configuration, the anchor ends 122, 124, 126, and 128 are moved toward obstructing member 110, and anchors 112, 114, 116, and 118 thereby folded toward obstructing member 110. In an alternative embodiment, the anchor ends 122, 124, 126, and 128 are moved away from obstructing member 110, and anchors 112, 114, 116, and 118 thereby folded away from obstructing member 110.
  • When [0065] intra-bronchial device 100 is deployed from the catheter lumen, the memory and resiliency of the anchors 112, 114, 116, and 118 impart a force that moves the anchor ends 122, 124, 126, and 128 into a second configuration to engage air passageway wall 130. This is the deployed configuration illustrated in FIG. 8. For removal, drawing intra-bronchial device 140 toward the catheter causes the anchor ends 122, 124, 126, and 128 to move away from obstructing member 110 to a third configuration. Anchors 112, 114, 116, and 118 are thereby folded away from obstructing member 110 and are released from engagement with air passageway wall 130 for removal of the intra-bronchial device 140. In an alternative embodiment, the anchors 112, 114, 116, and 118 may be formed on additional support members carried by central support structure 109, instead of being formed from distal portions of support members 102, 104, 106, and 108.
  • FIGS. [0066] 9-11 illustrate an intra-bronchial device, with proximal anchors carried on the central support structure, in accordance with an alternative embodiment of the invention. FIG. 9 is a perspective view, FIG. 10 is a side view, and FIG. 11 is an end view of the device. Intra-bronchial device 150 is generally similar in construction, operation, placement, and removal to the intra-bronchial device 100 of FIG. 5. Its structure has six support members and three anchors, with anchor stops. Anchors 112, 114, and 116 include stops 152, 154, and 156 respectively. Intra-bronchial device 150 also includes an anchor base 161, an anchor base aperture 165, anchor base angle 163, and two additional support members 103 and 105.
  • [0067] Central support structure 109 extends both proximal and distal of obstructing member 110, and carries anchor base 161 proximal of obstructing member 110, carries anchors 112, 114, and 116, and includes anchor base aperture 165. The linear plane of anchors 112, 114, and 116 intersect anchor base 161 at anchor base angle 163. Anchor base angle 163 is selected to optimize anchor deployment force and anchor release. Stops 152, 154, and 156 include a flat area to limit the piercing of the air passageway wall by anchor ends 122, 124, and 126. In alternative embodiments, the stops can be any configuration or shape known to those skilled in the art to limit the piercing.
  • In operation, when [0068] intra-bronchial device 150 is compressed for insertion into the catheter lumen for placement in the air passageway, anchors 112, 114, and 116 are collapsed into a first configuration. In the first configuration, the anchor ends 122, 124, and 126 are moved toward obstructing member 110, thereby decreasing anchor base angle 163 and folding anchors 112, 114, and 116 toward obstructing member 110. The anchor ends and the anchors may be moved by sliding a catheter or hollow member over anchor base 161 and toward obstructing member 110. When intra-bronchial device 150 is deployed from the catheter lumen, the memory and resiliency of the anchors 112, 114, and 116, anchor angle 163, and anchor base 161 impart a force that moves the anchor members into a second configuration, which is the deployed configuration, to engage air passageway wall 130. The second or deployed configuration is illustrated in FIGS. 9-11. Stops 152, 154, and 156 limit the piercing of the air passageway wall by anchor ends 122, 124, and 126.
  • For removal, a retractor device is deployed from a catheter to engage [0069] anchor base 161 and restrain intra-bronchial device 150. Anchor base aperture 165 is arranged for being gripped by a retractor device. The retractor device may be a biopsy forceps to engage anchor base 161, or a hooked device to engage anchor base aperture 165. The retractor device is then used to draw intra-bronchial device 150 proximal, releasing the anchors 112, 114, and 116 from the air passageway wall. This collapses the anchors into to the first configuration for removal.
  • In an alternative step to collapse the anchors, after [0070] anchor base 161 or aperture 165 is engaged, a catheter may then moved distally over anchor base 161, and in contact with anchors 112, 114, and 116. The catheter is further moved against anchors 112, 114, and 116, while intra-bronchial device 150 is restrained at anchor base 161. This releases the anchors 112, 114, and 116 from the air passageway wall. This collapses the anchors into to the first configuration for removal.
  • Continuing with the removal steps, [0071] intra-bronchial device 150 is then further drawn into the catheter by pulling on the retractor device used to engage anchor base 161. This collapses support structure 101 and obstructing member 110 so that they may be fully drawn into the catheter. Once drawn into the catheter, intra-bronchial device 160 may be removed from the air passageway and the patient.
  • FIGS. [0072] 12-14 illustrate an intra-bronchial device, with distal friction anchors carried on the central support structure, in accordance with an alternative embodiment of the invention. FIG. 12 is a perspective view, FIG. 13 is a side view, and FIG. 14 is an end view. Intra-bronchial device 160 is generally similar in construction, placement, and operation to the intra-bronchial device 150 of FIGS. 9-11. Intra-bronchial device 160 is removed in the manner described in conjunction with FIG. 7. However, Intra-bronchial device 160 differs from intra-bronchial device 150 in that the structure includes four distal anchors with anchor ends 122, 124, 126, and 128 shaped into pads that deform and frictionally engage the air passageway wall to more positively anchor intra-bronchial device 160 without piercing. The structure also includes an obstructing member support base 170.
  • [0073] Central support structure 109 extends distal of obstructing member 110, and carries anchor base 161 distal of obstructing member 110. Anchor base 161 carries anchors 112, 114, 116, and 118. The linear plane of anchors 112, 114, 116, and 118 intersects anchor base 161 at anchor angle 163. Anchor angle 163 is selected to optimize anchor deployment force and anchor release. The anchors 112, 114, 116, and 118, and anchor base 161 may be constructed by laser cutting a single piece of hypodermic tubing lengthwise to form the anchors 112, 114, 116, and 118, and then bending the anchors to form anchor angle 163. Anchor base 161 is secured to central support structure 109. Support members 102, 103, 104, 105, 106, and 108, and the obstructing member support member base 170 may be constructed in a like manner. Obstructing member 110 is secured to the obstructing member support base 170, and alternatively to support members 102, 103, 104, 105, 106, and 108. The assembly of obstructing member 110 and support base 170 is secured to central support structure 109. Central support structure 109 may extend proximal of support member base 170 to provide a surface for gripping the intra-bronchial device 160 for removal, and may include an aperture to be engaged by a hooked device.
  • FIG. 15 is a perspective view of an intra-bronchial device similar to that of FIGS. [0074] 12-14 anchored in an air passageway. It illustrates pad-shaped anchor ends 122-128 of intra-bronchial device 180 deforming and frictionally engaging air passageway wall 130.
  • FIGS. 16 and 17 illustrate a removable intra-bronchial device with proximal anchors carried on a peripheral portion of a plurality of support structure members in accord with the present invention. FIG. 16 is a perspective view, as the device would appear when fully deployed in an air passageway. FIG. 17 is a side view of FIG. 16. In a preferred embodiment, the [0075] support structure 101 of intra-bronchial device 190 includes six support members, with two opposing pairs of support members carrying anchors and each member of a pair being joined together by a retracting member. Intra-bronchial device 190 includes a support structure 101 having a central support structure 109 and support members 102, 103, 104, 105, 106, and 108; four anchors 113, 114, 116, and 118 having anchor ends 123, 124, 126, and 128 respectively; two “U” shaped retracting members 192 and 194 having an apex 193 and 195 respectively; and obstructing member 110.
  • [0076] Intra-bronchial device 190 is generally similar in construction, operation, placement, and removal to the intra-bronchial device 150 of FIG. 9. Support structure 101 is a tubular member, preferably hypodermic needle tubing, or stainless steel, Nitinol, or other suitable material having a memory of its original shape and resiliency to return the material to that shape. Support members 102, 103, 104, 105, 106, and 108, and central support structure 109 may be formed by laser cutting a single piece of hypodermic needle tubing lengthwise, and bending the support members to a required shape. Support members 102, 103, 104, 105, 106, and 108 are generally similar to each other. Anchors 113, 114, 116, and 118 are disposed on support members 103, 104, 106, and 108, respectively, in any manner available in the art. Anchors 113-118 are disposed on support members 103, 104, 106, and 108 to be located proximally of obstructing member 110, and to engage an air passageway wall when intra-bronchial device 190 is deployed.
  • “U” shaped retracting [0077] member 192 is coupled to support members 103 and 104, and “U” shaped retracting member 194 is coupled to support members 106 and 108. “U” shaped retracting members 192 and 194 may be constructed of any material suitable for use within a patient, and may or may not be resilient as required by the particular embodiment. When intra-bronchial device 190 is fully deployed in an air passageway, the “U” shaped retracting members 192 and 194 are arranged opposite each other, and they partially overlap, with the apex of one lying within a space bounded by the “U” shape of the other member. In the deployed configuration, increasing the distance between apex 193 and apex 195 moves support member pairs 103-104 and 106-108 centrally.
  • In operation, when [0078] intra-bronchial device 190 is compressed for insertion into a catheter lumen and placement in an air passageway, support members 102, 103, 104, 105, 106, and 108 are collapsed centrally into a first configuration. This causes the anchor ends 123, 124, 126 and 128 to move centrally.
  • When [0079] intra-bronchial device 190 is deployed from the catheter lumen, the memory and resiliency of the support member pairs 103,104 and 106,108 impart a force that moves the anchors 113 and 114, and 116 and 118, and their anchor ends 123 and 124, and 126 and 128 into a second configuration, which is the deployed configuration to engage air passageway wall. In addition, deployment of intra-bronchial device 190 may include a step of forcibly decreasing the distance between apexes 193 and 195 to forcibly move the anchors 113 and 114, and 116 and 118 into engagement with the wall of the air passageway. While the anchors 113 and 114, and 116 and 118 of this embodiment do not include stops, the expansive or peripheral movement of the anchors will be limited by the interior surface of obstructing member 110. This may limit the piercing of the air passageway wall by anchors 113 and 114, and 116 and 118.
  • In an alternative embodiment, support member pairs [0080] 103,104 and 106,108 may be compressed for insertion into a catheter lumen by a device that increases the distance between apex 193 and apex 195. Such a device could be a tool with spreading jaws, or a tapered member inserted between the apexes. The device could be left in engagement after insertion into the catheter, and then withdrawn to allow support member pairs 103-104 and 106-108 to move apart and engage their anchors into the wail of the air passageway.
  • For removal, a retractor device is deployed from a catheter lumen to engage apex [0081] 193 and 195, and restrain intra-bronchial device 190. The retractor device may be any device that fits into the space defined by apexes 193 and 195 when the intra-bronchial device 190 is in its fully deployed configuration. The retractor device is used to increase the distance between apexes 193 and 195 until anchors 113, 114, 116, and 118, and anchor ends 123, 124, 126, and 128 are released from the air passageway wall. This collapses the anchors into to the first configuration for removal. Intra-bronchial device 190 is then further collapsed, and drawn into the catheter by pulling on the retractor device. This additionally collapses support structure 101 and obstructing member 110 into the first position so that they may be fully drawn into the catheter. Once drawn into the catheter, intra-bronchial device 190 may be removed from the air passageway and the patient.
  • FIG. 18 is a perspective view illustrating an alternative embodiment of a removable intra-bronchial device [0082] 200 with both distal and proximal anchors carried on corresponding peripheral portions of central support structure 109 in accord with the present invention. FIG. 19 is a side view of the device 200 of FIG. 18. Intra-bronchial device 200 is generally similar in construction, placement, and operation to intra-bronchial device 150 of FIGS. 9-11. Intra-bronchial device 200 is removed in the manner described in conjunction with FIG. 7. Intra-bronchial device 200 differs from intra-bronchial device 150 in that the central support structure 109 carries distal anchors in addition to the proximal anchors of device 150. Intra-bronchial device 200 includes distal anchors 212, 213, 214, 216, and 218; anchor ends 222, 223, 224, 226, and 228; and stops 252, 253, 254, 256, and 258. Intra-bronchial device 200 also include two more proximal anchors than device 150, which are proximal anchors 113 and 118; anchor ends 123 and 128, and stops 153 and 158.
  • The [0083] central support structure 109 of support structure 101 extends both distally and proximally of obstructing member 110, and carries both the proximal anchors 112, 113, 114, 116, and 118 and distal anchors 212, 213, 214, 216, and 218. The support structure 101 also includes support members 102, 103, 104, 106, and 108. Because of the perspective of FIGS. 18 and 19, several of the anchor members and several of the support members are not visible. Intra-bronchial device 200 is expected to provide additional anchoring force compared to the other embodiments disclosed herein.
  • Although the present invention has been described in considerable detail with reference to certain preferred embodiments, other embodiments are possible. Therefore, the spirit or scope of the appended claims should not be limited to the description of the embodiments contained herein. It is intended that the invention resides in the claims hereinafter appended. [0084]

Claims (31)

What is claimed is:
1. An intra-bronchial device for placement in an air passageway of a patient to collapse a lung portion associated with the air passageway, the device comprising:
a support structure;
an obstructing member carried by the support structure that prevents air from being inhaled into the lung portion to collapse the lung portion; and
at least one anchor carried by the support structure that anchors the obstruction device within the air passageway when the anchor is deployed.
2. The intra-bronchial device of claim 1, wherein at least one anchor has an anchoring end that engages the air passageway wall.
3. The intra-bronchial device of claim 1, wherein the obstructing member and at least one anchor are simultaneously deployable.
4. The intra-bronchial device of claim 1, wherein at least one anchor is releasable from the air passageway for removal of the intra-bronchial device.
5. The intra-bronchial device of claim 1, wherein at least one anchor pierces into the air passageway wall.
6. The intra-bronchial device of claim 1, wherein at least a portion of the support structure is collapsible.
7. The intra-bronchial device of claim 1, wherein at least one anchor includes a stop dimensioned for limiting the piercing of the air passageway wall.
8. The intra-bronchial device of claim 1, wherein at least one anchor is configured to move from a first configuration to a second configuration to engage the air passageway.
9. The intra-bronchial device of claim 1, wherein at least one anchor is configured to move from a first configuration to a second configuration to engage the air passageway, and to move from the second configuration to the first configuration to disengage the air passageway.
10. The intra-bronchial device of claim 1, wherein at least one anchor is configured to move from a first configuration to a second configuration to engage the air passageway, and to move from the second configuration to a third configuration to disengage the air passageway.
11. The intra-bronchial device of claim 1, wherein the support structure is configured to urge at least one anchor to engage the air passageway wall.
12. The intra-bronchial device of claim 1, wherein the anchor includes a resilient material for imparting a force against the air passageway to deform the air passageway to more positively anchor the obstructing member.
13. The intra-bronchial device of claim 1, wherein the anchor includes at least one pad that frictionally engages the air passageway.
14. The intra-bronchial device of claim 1, wherein the obstructing member is a one-way valve.
15. The intra-bronchial device of claim 1, wherein at least one anchor is carried by a peripheral portion of the support structure.
16. The intra-bronchial device of claim 1, wherein at least one anchor is carried by a central portion of the support structure.
17. The intra-bronchial device of claim 1, wherein the obstructing member is releasable from the support structure and removable from the air passageway.
18. The intra-bronchial device of claim 1, wherein at least one anchor is carried distal to the obstructing member.
19. The intra-bronchial device of claim 1, wherein at least one anchor is carried proximal to the obstructing member.
20. The intra-bronchial device of claim 1, wherein at least one anchor is carried distal to the obstructing member and at least one anchor is carried proximal to the obstructing member.
21. A method of reducing the size of a lung by collapsing a portion of the lung, the method including the steps of:
providing an intra-bronchial device comprising a support structure, an obstructing member carried by the support structure which is so dimensioned when deployed in an air passageway communicating with the portion of the lung to be collapsed to preclude air from being inhaled, and at least one anchor carried by the support structure that anchors the obstructing member when the anchor is deployed;
placing the obstructing member in the air passageway; and
deploying at least one anchor.
22. The method of claim 21, wherein at least one anchor is releasable for removal of the intra-bronchial device.
23. The method of claim 21, wherein the obstructing member forms a one-way valve.
24. The method of claim 21, wherein at least a portion of the support structure is collapsible.
25. A method of reducing the size of a lung by collapsing a portion of the lung with a removable device, the method including the steps of:
providing an intra-bronchial device comprising a support structure, an obstructing member carried by the support structure which is so dimensioned when deployed in an air passageway communicating with the portion of the lung to be collapsed to preclude air from being inhaled, and at least one anchor carried by the support structure that anchors the obstructing member when the anchor is deployed;
placing the obstructing member in the air passageway;
deploying at least one anchor; and
removing at least the obstructing member.
26. The method of claim 25, wherein at least one anchor is releasable from the air passageway for removal of the intra-bronchial device, and the step of removing at least the obstructing member includes releasing at least one anchor.
27. The method of claim 25, wherein at least a portion of the obstructing member is releasable from the support structure, and the step of removing at least the obstructing member includes releasing the obstructing member from the support structure.
28. The method of claim 25, wherein the obstructing member forms a one-way valve.
29. The method of claim 25, wherein at least a portion of the support structure is collapsible.
30. An air passageway obstructing device comprising:
frame means for forming a support structure;
flexible membrane means for obstructing air flow within the air passageway, carried by the support structure; and
anchoring means to anchor the air passageway obstructing device, carried by the support structure,
the frame means being expandable to an expanded state within an air passageway to support the membrane means and the anchoring means, the anchoring means being releasable for removal of the device from the air passageway.
31. The intra-bronchial device of claim 1, wherein the support structure comprises material having memory of an original shape, and resiliency to return the material to that shape.
US10/150,547 2002-03-20 2002-05-17 Removable anchored lung volume reduction devices and methods Abandoned US20030216769A1 (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
US10/150,547 US20030216769A1 (en) 2002-05-17 2002-05-17 Removable anchored lung volume reduction devices and methods
AU2003219927A AU2003219927A1 (en) 2002-03-20 2003-02-26 Removable anchored lung volume reduction devices and methods
CA002479805A CA2479805A1 (en) 2002-03-20 2003-02-26 Removable anchored lung volume reduction devices and methods
JP2003577779A JP4387803B2 (en) 2002-03-20 2003-02-26 Detachable anchored lung volume reduction device
EP10196887.3A EP2353557B1 (en) 2002-03-20 2003-02-26 Removable anchored lung volume reduction devices
EP03716212.0A EP1494632B1 (en) 2002-03-20 2003-02-26 Removable anchored lung volume reduction devices
PCT/US2003/005968 WO2003079944A1 (en) 2002-03-20 2003-02-26 Removable anchored lung volume reduction devices and methods
US10/744,577 US7434578B2 (en) 2002-05-17 2003-12-22 Methods of achieving lung volume reduction with removable anchored devices
US10/746,981 US7842061B2 (en) 2002-05-17 2003-12-23 Methods of achieving lung volume reduction with removable anchored devices
US10/933,778 US7875048B2 (en) 2002-05-17 2004-09-03 One-way valve devices for anchored implantation in a lung
US12/968,771 US8257381B2 (en) 2002-05-17 2010-12-15 One-way valve devices for anchored implantation in a lung
US13/554,987 US8956319B2 (en) 2002-05-17 2012-07-20 One-way valve devices for anchored implantation in a lung
US14/622,234 US9358013B2 (en) 2002-05-17 2015-02-13 One-way valve devices for anchored implantation in a lung

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US10/150,547 US20030216769A1 (en) 2002-05-17 2002-05-17 Removable anchored lung volume reduction devices and methods

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US10/744,577 Division US7434578B2 (en) 2002-05-17 2003-12-22 Methods of achieving lung volume reduction with removable anchored devices
US10/746,981 Division US7842061B2 (en) 2002-05-17 2003-12-23 Methods of achieving lung volume reduction with removable anchored devices
US10/933,778 Continuation US7875048B2 (en) 2002-05-17 2004-09-03 One-way valve devices for anchored implantation in a lung

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US20030216769A1 true US20030216769A1 (en) 2003-11-20

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US10/150,547 Abandoned US20030216769A1 (en) 2002-03-20 2002-05-17 Removable anchored lung volume reduction devices and methods
US10/744,577 Active 2024-08-04 US7434578B2 (en) 2002-05-17 2003-12-22 Methods of achieving lung volume reduction with removable anchored devices
US10/746,981 Expired - Lifetime US7842061B2 (en) 2002-05-17 2003-12-23 Methods of achieving lung volume reduction with removable anchored devices
US10/933,778 Expired - Fee Related US7875048B2 (en) 2002-05-17 2004-09-03 One-way valve devices for anchored implantation in a lung
US12/968,771 Active US8257381B2 (en) 2002-05-17 2010-12-15 One-way valve devices for anchored implantation in a lung
US13/554,987 Expired - Fee Related US8956319B2 (en) 2002-05-17 2012-07-20 One-way valve devices for anchored implantation in a lung
US14/622,234 Expired - Lifetime US9358013B2 (en) 2002-05-17 2015-02-13 One-way valve devices for anchored implantation in a lung

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Cited By (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030050648A1 (en) * 2001-09-11 2003-03-13 Spiration, Inc. Removable lung reduction devices, systems, and methods
US20030212412A1 (en) * 2002-05-09 2003-11-13 Spiration, Inc. Intra-bronchial obstructing device that permits mucus transport
WO2004080347A2 (en) 2003-03-12 2004-09-23 Spiration Inc. Apparatus, method and assembly for delivery of intra-bronchial devices
US20070232992A1 (en) * 2006-03-31 2007-10-04 James Kutsko Articulable anchor
US7451765B2 (en) 2004-11-18 2008-11-18 Mark Adler Intra-bronchial apparatus for aspiration and insufflation of lung regions distal to placement or cross communication and deployment and placement system therefor
US7682332B2 (en) 2003-07-15 2010-03-23 Portaero, Inc. Methods to accelerate wound healing in thoracic anastomosis applications
US7686013B2 (en) 2006-01-17 2010-03-30 Portaero, Inc. Variable resistance pulmonary ventilation bypass valve
US7753052B2 (en) 2003-06-05 2010-07-13 Portaero, Inc. Intra-thoracic collateral ventilation bypass system
US7789083B2 (en) 2003-05-20 2010-09-07 Portaero, Inc. Intra/extra thoracic system for ameliorating a symptom of chronic obstructive pulmonary disease
US7811274B2 (en) 2003-05-07 2010-10-12 Portaero, Inc. Method for treating chronic obstructive pulmonary disease
US7824366B2 (en) 2004-12-10 2010-11-02 Portaero, Inc. Collateral ventilation device with chest tube/evacuation features and method
US7842061B2 (en) 2002-05-17 2010-11-30 Spiration, Inc. Methods of achieving lung volume reduction with removable anchored devices
US7896008B2 (en) 2003-06-03 2011-03-01 Portaero, Inc. Lung reduction system
US7909803B2 (en) 2008-02-19 2011-03-22 Portaero, Inc. Enhanced pneumostoma management device and methods for treatment of chronic obstructive pulmonary disease
US7931641B2 (en) 2007-05-11 2011-04-26 Portaero, Inc. Visceral pleura ring connector
US7942931B2 (en) 2002-02-21 2011-05-17 Spiration, Inc. Device and method for intra-bronchial provision of a therapeutic agent
US8021385B2 (en) 2002-03-20 2011-09-20 Spiration, Inc. Removable anchored lung volume reduction devices and methods
US8043301B2 (en) 2007-10-12 2011-10-25 Spiration, Inc. Valve loader method, system, and apparatus
US8062315B2 (en) 2007-05-17 2011-11-22 Portaero, Inc. Variable parietal/visceral pleural coupling
US8079368B2 (en) 2003-04-08 2011-12-20 Spiration, Inc. Bronchoscopic lung volume reduction method
US8104474B2 (en) 2005-08-23 2012-01-31 Portaero, Inc. Collateral ventilation bypass system with retention features
US8136230B2 (en) 2007-10-12 2012-03-20 Spiration, Inc. Valve loader method, system, and apparatus
US8163034B2 (en) 2007-05-11 2012-04-24 Portaero, Inc. Methods and devices to create a chemically and/or mechanically localized pleurodesis
US8220460B2 (en) 2004-11-19 2012-07-17 Portaero, Inc. Evacuation device and method for creating a localized pleurodesis
US8336540B2 (en) 2008-02-19 2012-12-25 Portaero, Inc. Pneumostoma management device and method for treatment of chronic obstructive pulmonary disease
US8347881B2 (en) 2009-01-08 2013-01-08 Portaero, Inc. Pneumostoma management device with integrated patency sensor and method
US8475389B2 (en) 2008-02-19 2013-07-02 Portaero, Inc. Methods and devices for assessment of pneumostoma function
US8518053B2 (en) 2009-02-11 2013-08-27 Portaero, Inc. Surgical instruments for creating a pneumostoma and treating chronic obstructive pulmonary disease
US8795241B2 (en) 2011-05-13 2014-08-05 Spiration, Inc. Deployment catheter
US8974527B2 (en) 2003-08-08 2015-03-10 Spiration, Inc. Bronchoscopic repair of air leaks in a lung
WO2015153500A1 (en) * 2014-03-31 2015-10-08 Spiration, Inc. Simulated valve device for airway
JP2017213388A (en) * 2009-05-18 2017-12-07 ヌームアールエックス・インコーポレーテッド Cross-sectional modification method during deployment of elongate lung volume reduction device
CN110742667A (en) * 2018-07-23 2020-02-04 苏州优友瑞医疗科技有限公司 Methods and devices for treating pulmonary dysfunction using implantable valves
US10624733B2 (en) 2015-03-24 2020-04-21 Spiration, Inc. Airway stent
CN111513662A (en) * 2014-03-31 2020-08-11 捷锐士股份有限公司 Anchoring mechanisms and systems for endoluminal devices
US11039926B2 (en) 2016-03-25 2021-06-22 Spiration, Inc. Valve planning tool
CN116531142A (en) * 2023-06-13 2023-08-04 金傅(北京)医疗科技有限公司 Double-layer tectorial membrane structure of bronchus valve

Families Citing this family (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6722360B2 (en) * 2000-06-16 2004-04-20 Rajiv Doshi Methods and devices for improving breathing in patients with pulmonary disease
US7011094B2 (en) * 2001-03-02 2006-03-14 Emphasys Medical, Inc. Bronchial flow control devices and methods of use
US6592594B2 (en) 2001-10-25 2003-07-15 Spiration, Inc. Bronchial obstruction device deployment system and method
US20030154988A1 (en) * 2002-02-21 2003-08-21 Spiration, Inc. Intra-bronchial device that provides a medicant intra-bronchially to the patient
US7533667B2 (en) * 2003-05-29 2009-05-19 Portaero, Inc. Methods and devices to assist pulmonary decompression
US20050178389A1 (en) * 2004-01-27 2005-08-18 Shaw David P. Disease indications for selective endobronchial lung region isolation
US20060030921A1 (en) * 2004-08-03 2006-02-09 Medtronic Vascular, Inc. Intravascular securement device
US7398782B2 (en) * 2004-11-19 2008-07-15 Portaero, Inc. Method for pulmonary drug delivery
US20060118126A1 (en) * 2004-11-19 2006-06-08 Don Tanaka Methods and devices for controlling collateral ventilation
US7771472B2 (en) * 2004-11-19 2010-08-10 Pulmonx Corporation Bronchial flow control devices and methods of use
US8061357B2 (en) 2004-12-08 2011-11-22 Ventus Medical, Inc. Adhesive nasal respiratory devices
US10610228B2 (en) 2004-12-08 2020-04-07 Theravent, Inc. Passive nasal peep devices
WO2006063339A2 (en) * 2004-12-08 2006-06-15 Ventus Medical, Inc. Respiratory devices and methods of use
US9833354B2 (en) 2004-12-08 2017-12-05 Theravent, Inc. Nasal respiratory devices
US7806120B2 (en) * 2004-12-08 2010-10-05 Ventus Medical, Inc. Nasal respiratory devices for positive end-expiratory pressure
US8136526B2 (en) * 2006-03-08 2012-03-20 Pulmonx Corporation Methods and devices to induce controlled atelectasis and hypoxic pulmonary vasoconstriction
US9402633B2 (en) 2006-03-13 2016-08-02 Pneumrx, Inc. Torque alleviating intra-airway lung volume reduction compressive implant structures
US8157837B2 (en) * 2006-03-13 2012-04-17 Pneumrx, Inc. Minimally invasive lung volume reduction device and method
US8888800B2 (en) 2006-03-13 2014-11-18 Pneumrx, Inc. Lung volume reduction devices, methods, and systems
EP2026723B1 (en) 2006-05-23 2018-11-21 Theravent, Inc. Nasal respiratory devices
EP2032213A4 (en) * 2006-06-07 2014-02-19 Theravent Inc Nasal devices
US20110203598A1 (en) * 2006-06-07 2011-08-25 Favet Michael L Nasal devices including layered nasal devices and delayed resistance adapters for use with nasal devices
US20090145441A1 (en) * 2007-12-06 2009-06-11 Rajiv Doshi Delayed resistance nasal devices and methods of use
WO2008027293A2 (en) * 2006-08-25 2008-03-06 Emphasys Medical, Inc. Bronchial isolation devices for placement in short lumens
EP2066241B1 (en) * 2006-09-29 2010-06-02 Cordis Corporation Single disc intraluminal fixation patent foramen ovale closure device
US7534261B2 (en) * 2006-10-02 2009-05-19 Edwards Lifesciences Corporation Sutureless heart valve attachment
US8240309B2 (en) * 2006-11-16 2012-08-14 Ventus Medical, Inc. Adjustable nasal devices
TW200836781A (en) * 2007-03-07 2008-09-16 Ventus Medical Inc Nasal devices
US20080281151A1 (en) * 2007-05-11 2008-11-13 Portaero, Inc. Pulmonary pleural stabilizer
US20080283065A1 (en) * 2007-05-15 2008-11-20 Portaero, Inc. Methods and devices to maintain patency of a lumen in parenchymal tissue of the lung
US20080295829A1 (en) * 2007-05-30 2008-12-04 Portaero, Inc. Bridge element for lung implant
US8020700B2 (en) 2007-12-05 2011-09-20 Ventus Medical, Inc. Packaging and dispensing nasal devices
AU2009212689A1 (en) * 2008-02-01 2009-08-13 Ventus Medical, Inc. CPAP interface and backup devices
US9867652B2 (en) 2008-04-29 2018-01-16 Virginia Tech Intellectual Properties, Inc. Irreversible electroporation using tissue vasculature to treat aberrant cell masses or create tissue scaffolds
US11254926B2 (en) 2008-04-29 2022-02-22 Virginia Tech Intellectual Properties, Inc. Devices and methods for high frequency electroporation
US10238447B2 (en) 2008-04-29 2019-03-26 Virginia Tech Intellectual Properties, Inc. System and method for ablating a tissue site by electroporation with real-time monitoring of treatment progress
US10272178B2 (en) 2008-04-29 2019-04-30 Virginia Tech Intellectual Properties Inc. Methods for blood-brain barrier disruption using electrical energy
US10448989B2 (en) 2009-04-09 2019-10-22 Virginia Tech Intellectual Properties, Inc. High-frequency electroporation for cancer therapy
US9283051B2 (en) 2008-04-29 2016-03-15 Virginia Tech Intellectual Properties, Inc. System and method for estimating a treatment volume for administering electrical-energy based therapies
US9598691B2 (en) 2008-04-29 2017-03-21 Virginia Tech Intellectual Properties, Inc. Irreversible electroporation to create tissue scaffolds
US11272979B2 (en) 2008-04-29 2022-03-15 Virginia Tech Intellectual Properties, Inc. System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies
US9198733B2 (en) 2008-04-29 2015-12-01 Virginia Tech Intellectual Properties, Inc. Treatment planning for electroporation-based therapies
US8992517B2 (en) 2008-04-29 2015-03-31 Virginia Tech Intellectual Properties Inc. Irreversible electroporation to treat aberrant cell masses
US10702326B2 (en) 2011-07-15 2020-07-07 Virginia Tech Intellectual Properties, Inc. Device and method for electroporation based treatment of stenosis of a tubular body part
US10117707B2 (en) 2008-04-29 2018-11-06 Virginia Tech Intellectual Properties, Inc. System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies
US10245098B2 (en) 2008-04-29 2019-04-02 Virginia Tech Intellectual Properties, Inc. Acute blood-brain barrier disruption using electrical energy based therapy
US20090308398A1 (en) * 2008-06-16 2009-12-17 Arthur Ferdinand Adjustable resistance nasal devices
US8632605B2 (en) 2008-09-12 2014-01-21 Pneumrx, Inc. Elongated lung volume reduction devices, methods, and systems
USD628288S1 (en) 2009-01-22 2010-11-30 Resmed Limited Cuff for air delivery tube
US20110282456A1 (en) * 2009-02-05 2011-11-17 Newvert Ltd. Implantable device for sealing a spinal annular fissure tear and method for deploying the same
US11382681B2 (en) 2009-04-09 2022-07-12 Virginia Tech Intellectual Properties, Inc. Device and methods for delivery of high frequency electrical pulses for non-thermal ablation
US11638603B2 (en) 2009-04-09 2023-05-02 Virginia Tech Intellectual Properties, Inc. Selective modulation of intracellular effects of cells using pulsed electric fields
US8903488B2 (en) 2009-05-28 2014-12-02 Angiodynamics, Inc. System and method for synchronizing energy delivery to the cardiac rhythm
US9895189B2 (en) 2009-06-19 2018-02-20 Angiodynamics, Inc. Methods of sterilization and treating infection using irreversible electroporation
US20110108041A1 (en) * 2009-11-06 2011-05-12 Elliot Sather Nasal devices having a safe failure mode and remotely activatable
US8425455B2 (en) 2010-03-30 2013-04-23 Angiodynamics, Inc. Bronchial catheter and method of use
US8875711B2 (en) 2010-05-27 2014-11-04 Theravent, Inc. Layered nasal respiratory devices
US9084859B2 (en) 2011-03-14 2015-07-21 Sleepnea Llc Energy-harvesting respiratory method and device
US8840664B2 (en) 2011-06-15 2014-09-23 Edwards Lifesciences Corporation Heart valve prosthesis anchoring device and methods
EP2758010B1 (en) 2011-09-23 2017-02-08 Pulmonx, Inc Implant loading system
US9078665B2 (en) 2011-09-28 2015-07-14 Angiodynamics, Inc. Multiple treatment zone ablation probe
WO2013130484A1 (en) * 2012-02-28 2013-09-06 Spiration, Inc. Pulmonary nodule access devices and methods of using the same
AU2013355303B2 (en) 2012-12-04 2017-12-14 Mallinckrodt Hospital Products IP Limited Cannula for minimizing dilution of dosing during nitric oxide delivery
US9795756B2 (en) 2012-12-04 2017-10-24 Mallinckrodt Hospital Products IP Limited Cannula for minimizing dilution of dosing during nitric oxide delivery
US8984733B2 (en) 2013-02-05 2015-03-24 Artventive Medical Group, Inc. Bodily lumen occlusion
US9636116B2 (en) 2013-06-14 2017-05-02 Artventive Medical Group, Inc. Implantable luminal devices
US10149968B2 (en) * 2013-06-14 2018-12-11 Artventive Medical Group, Inc. Catheter-assisted tumor treatment
CA2917573A1 (en) * 2013-07-11 2015-01-15 Shifamed Holdings, Llc Devices and methods for lung volume reduction
WO2015061790A2 (en) 2013-10-25 2015-04-30 Pneumrx, Inc. Genetically-associated chronic obstructive pulmonary disease treatment
US10004512B2 (en) * 2014-01-29 2018-06-26 Cook Biotech Incorporated Occlusion device and method of use thereof
EP3122233B1 (en) 2014-03-28 2018-10-24 Spiration, Inc. D.B.A. Olympus Respiratory America System for predictable deployment of a medical device
JP6594901B2 (en) 2014-05-12 2019-10-23 バージニア テック インテレクチュアル プロパティース インコーポレイテッド Selective modulation of intracellular effects of cells using pulsed electric fields
US20150342610A1 (en) * 2014-05-29 2015-12-03 Pulmonx Corporation Medical devices and methods for lung volume reduction
ES2755370T3 (en) * 2014-07-18 2020-04-22 Ethicon Inc Devices to control the size of the emphysematous bulla
EP3169247B1 (en) 2014-07-18 2020-05-13 Ethicon, Inc. Mechanical retraction via tethering for lung volume reduction
US10390838B1 (en) 2014-08-20 2019-08-27 Pneumrx, Inc. Tuned strength chronic obstructive pulmonary disease treatment
WO2016100325A1 (en) 2014-12-15 2016-06-23 Virginia Tech Intellectual Properties, Inc. Devices, systems, and methods for real-time monitoring of electrophysical effects during tissue treatment
WO2016115193A1 (en) * 2015-01-14 2016-07-21 Shifamed Holdings, Llc Devices and methods for lung volume reduction
WO2017053935A1 (en) * 2015-09-25 2017-03-30 Soffio Medical Inc. Expandable structure to treat hyperinflated lung
US10603021B2 (en) * 2015-10-02 2020-03-31 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Endo-cameral closure device
GB2557813B (en) 2015-10-20 2020-10-28 Gyrus Acmi Inc Ablation device
GB2563362B (en) * 2016-03-30 2021-10-13 Gyrus Acmi Inc Airway valve for irregular shaped airway
JP6695443B2 (en) * 2016-03-30 2020-05-20 スパイレーション インコーポレイテッド ディー ビー エイ オリンパス レスピラトリー アメリカ Airway valve including anchor
US10813644B2 (en) 2016-04-01 2020-10-27 Artventive Medical Group, Inc. Occlusive implant and delivery system
US10470839B2 (en) 2016-06-02 2019-11-12 Covidien Lp Assessment of suture or staple line integrity and localization of potential tissue defects along the suture or staple line
US10905492B2 (en) 2016-11-17 2021-02-02 Angiodynamics, Inc. Techniques for irreversible electroporation using a single-pole tine-style internal device communicating with an external surface electrode
DE112017007300T5 (en) 2017-03-23 2020-01-02 Spiration, Inc. D/B/A Olympus Respiratory America ATEMWEGVENTILVORRICHTUNG
US10433852B2 (en) 2017-05-08 2019-10-08 William Z. H'Doubler Aortic occlusion balloon apparatus, system and method of making
US11607537B2 (en) 2017-12-05 2023-03-21 Virginia Tech Intellectual Properties, Inc. Method for treating neurological disorders, including tumors, with electroporation
US10751160B2 (en) * 2018-01-29 2020-08-25 Gyrus Acmi, Inc. Removable anchored lung volume reduction devices
US11925405B2 (en) 2018-03-13 2024-03-12 Virginia Tech Intellectual Properties, Inc. Treatment planning system for immunotherapy enhancement via non-thermal ablation
US11311329B2 (en) 2018-03-13 2022-04-26 Virginia Tech Intellectual Properties, Inc. Treatment planning for immunotherapy based treatments using non-thermal ablation techniques
WO2020023365A1 (en) * 2018-07-23 2020-01-30 Eolo Medical Inc. Methods and devices for the treatment of pulmonary disorders with implantable valves
EP3958750A1 (en) 2019-04-22 2022-03-02 Eolo Medical Inc. Devices for the treatment of pulmonary disorders with implantable valves
WO2021150872A1 (en) 2020-01-22 2021-07-29 Eolo Medical Inc. Methods and devices for the treatment of pulmonary disorders with a braided implantable flow control device
DE102020006503A1 (en) 2020-10-22 2022-04-28 Universität Stuttgart Körperschaft des öffentlichen Rechts Endoluminal closure device, medical system and method for treatment of lung disease
EP4322888A1 (en) * 2021-04-16 2024-02-21 Free Flow Medical, Inc. Valved devices, treatments and methods to restore tissue elastic recoil

Citations (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2981254A (en) * 1957-11-12 1961-04-25 Edwin G Vanderbilt Apparatus for the gas deflation of an animal's stomach
US3540431A (en) * 1968-04-04 1970-11-17 Kazi Mobin Uddin Collapsible filter for fluid flowing in closed passageway
US3657744A (en) * 1970-05-08 1972-04-25 Univ Minnesota Method for fixing prosthetic implants in a living body
US3760808A (en) * 1969-12-01 1973-09-25 K Bleuer Tampon applicator assembly
US3788327A (en) * 1971-03-30 1974-01-29 H Donowitz Surgical implant device
US3874388A (en) * 1973-02-12 1975-04-01 Ochsner Med Found Alton Shunt defect closure system
US4014318A (en) * 1973-08-20 1977-03-29 Dockum James M Circulatory assist device and system
US4086665A (en) * 1976-12-16 1978-05-02 Thermo Electron Corporation Artificial blood conduit
US4212463A (en) * 1978-02-17 1980-07-15 Pratt Enoch B Humane bleeder arrow
US4250873A (en) * 1977-04-26 1981-02-17 Richard Wolf Gmbh Endoscopes
US4302854A (en) * 1980-06-04 1981-12-01 Runge Thomas M Electrically activated ferromagnetic/diamagnetic vascular shunt for left ventricular assist
US4619246A (en) * 1984-05-23 1986-10-28 William Cook, Europe A/S Collapsible filter basket
US4681110A (en) * 1985-12-02 1987-07-21 Wiktor Dominik M Catheter arrangement having a blood vessel liner, and method of using it
US4710192A (en) * 1985-12-30 1987-12-01 Liotta Domingo S Diaphragm and method for occlusion of the descending thoracic aorta
US4727873A (en) * 1984-04-17 1988-03-01 Mobin Uddin Kazi Embolus trap
US4732152A (en) * 1984-12-05 1988-03-22 Medinvent S.A. Device for implantation and a method of implantation in a vessel using such device
US4759758A (en) * 1984-12-07 1988-07-26 Shlomo Gabbay Prosthetic heart valve
US4795449A (en) * 1986-08-04 1989-01-03 Hollister Incorporated Female urinary incontinence device
US4808183A (en) * 1980-06-03 1989-02-28 University Of Iowa Research Foundation Voice button prosthesis and method for installing same
US4819664A (en) * 1984-11-15 1989-04-11 Stefano Nazari Device for selective bronchial intubation and separate lung ventilation, particularly during anesthesia, intensive therapy and reanimation
US4830003A (en) * 1988-06-17 1989-05-16 Wolff Rodney G Compressive stent and delivery system
US4832680A (en) * 1986-07-03 1989-05-23 C.R. Bard, Inc. Apparatus for hypodermically implanting a genitourinary prosthesis
US4846836A (en) * 1988-10-03 1989-07-11 Reich Jonathan D Artificial lower gastrointestinal valve
US4850999A (en) * 1980-05-24 1989-07-25 Institute Fur Textil-Und Faserforschung Of Stuttgart Flexible hollow organ
US4852568A (en) * 1987-02-17 1989-08-01 Kensey Nash Corporation Method and apparatus for sealing an opening in tissue of a living being
US4877025A (en) * 1988-10-06 1989-10-31 Hanson Donald W Tracheostomy tube valve apparatus
US4934999A (en) * 1987-07-28 1990-06-19 Paul Bader Closure for a male urethra
US4968294A (en) * 1989-02-09 1990-11-06 Salama Fouad A Urinary control valve and method of using same
US5061274A (en) * 1989-12-04 1991-10-29 Kensey Nash Corporation Plug device for sealing openings and method of use
US5116564A (en) * 1988-10-11 1992-05-26 Josef Jansen Method of producing a closing member having flexible closing elements, especially a heart valve
US5116360A (en) * 1990-12-27 1992-05-26 Corvita Corporation Mesh composite graft
US5123919A (en) * 1991-11-21 1992-06-23 Carbomedics, Inc. Combined prosthetic aortic heart valve and vascular graft
US5151105A (en) * 1991-10-07 1992-09-29 Kwan Gett Clifford Collapsible vessel sleeve implant
US5158548A (en) * 1990-04-25 1992-10-27 Advanced Cardiovascular Systems, Inc. Method and system for stent delivery
US5161524A (en) * 1991-08-02 1992-11-10 Glaxo Inc. Dosage inhalator with air flow velocity regulating means
US5283063A (en) * 1992-01-31 1994-02-01 Eagle Vision Punctum plug method and apparatus
US5304199A (en) * 1993-01-04 1994-04-19 Gene E. Myers Enterprises, Inc. Apparatus for arterial total occlusion plaque separation
US5306234A (en) * 1993-03-23 1994-04-26 Johnson W Dudley Method for closing an atrial appendage
US5314473A (en) * 1989-07-20 1994-05-24 Godin Norman J Prosthesis for preventing gastric reflux into the esophagus
US5352240A (en) * 1989-05-31 1994-10-04 Promedica International, Inc. Human heart valve replacement with porcine pulmonary valve
US5358518A (en) * 1991-06-25 1994-10-25 Sante Camilli Artificial venous valve
US5366478A (en) * 1993-07-27 1994-11-22 Ethicon, Inc. Endoscopic surgical sealing device
US5382261A (en) * 1992-09-01 1995-01-17 Expandable Grafts Partnership Method and apparatus for occluding vessels
US5392775A (en) * 1994-03-22 1995-02-28 Adkins, Jr.; Claude N. Duckbill valve for a tracheostomy tube that permits speech
US5409019A (en) * 1992-10-30 1995-04-25 Wilk; Peter J. Coronary artery by-pass method
US5453090A (en) * 1994-03-01 1995-09-26 Cordis Corporation Method of stent delivery through an elongate softenable sheath
US5509900A (en) * 1992-03-02 1996-04-23 Kirkman; Thomas R. Apparatus and method for retaining a catheter in a blood vessel in a fixed position
US5549626A (en) * 1994-12-23 1996-08-27 New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery Vena caval filter
US5603698A (en) * 1993-04-13 1997-02-18 Boston Scientific Corporation Prosthesis delivery system
US5755770A (en) * 1995-01-31 1998-05-26 Boston Scientific Corporatiion Endovascular aortic graft
US5797960A (en) * 1993-02-22 1998-08-25 Stevens; John H. Method and apparatus for thoracoscopic intracardiac procedures
US5803078A (en) * 1994-05-06 1998-09-08 Brauner; Mark E. Methods and apparatus for intrapulmonary therapy and drug administration
US5851232A (en) * 1997-03-15 1998-12-22 Lois; William A. Venous stent
US5855601A (en) * 1996-06-21 1999-01-05 The Trustees Of Columbia University In The City Of New York Artificial heart valve and method and device for implanting the same
US5925063A (en) * 1997-09-26 1999-07-20 Khosravi; Farhad Coiled sheet valve, filter or occlusive device and methods of use
US5954766A (en) * 1997-09-16 1999-09-21 Zadno-Azizi; Gholam-Reza Body fluid flow control device
US5954636A (en) * 1997-07-15 1999-09-21 Schwartz; Roy E. Pediatric endotracheal tube with bronchial blocker and method for selectively blocking respiratory airflow to a pediatric patient's lung
US6149664A (en) * 1998-08-27 2000-11-21 Micrus Corporation Shape memory pusher introducer for vasoocclusive devices
US6174323B1 (en) * 1998-06-05 2001-01-16 Broncus Technologies, Inc. Method and assembly for lung volume reduction
US6238334B1 (en) * 1997-11-03 2001-05-29 Cardio Technologies, Inc. Method and apparatus for assisting a heart to pump blood
US6258100B1 (en) * 1999-08-24 2001-07-10 Spiration, Inc. Method of reducing lung size
US6267775B1 (en) * 1997-03-21 2001-07-31 Schneider (Usa) Inc. Self-expanding medical device for centering radioactive treatment sources in body vessels
US6287334B1 (en) * 1996-12-18 2001-09-11 Venpro Corporation Device for regulating the flow of blood through the blood system
US6287290B1 (en) * 1999-07-02 2001-09-11 Pulmonx Methods, systems, and kits for lung volume reduction
US20010037808A1 (en) * 2000-03-04 2001-11-08 Deem Mark E. Methods and devices for use in performing pulmonary procedures
US6328689B1 (en) * 2000-03-23 2001-12-11 Spiration, Inc., Lung constriction apparatus and method
US20010051799A1 (en) * 1999-08-23 2001-12-13 Ingenito Edward P. Tissue volume reduction
US6398775B1 (en) * 1999-10-21 2002-06-04 Pulmonx Apparatus and method for isolated lung access
US20020112729A1 (en) * 2001-02-21 2002-08-22 Spiration, Inc. Intra-bronchial obstructing device that controls biological interaction with the patient
US6439233B1 (en) * 1999-02-01 2002-08-27 ADEVA Medical Gesellschaft für Entwicklung und Vertrieb von Medizinischen Implantat-Artikeln mbH Tracheal stoma valve
US6447530B1 (en) * 1996-11-27 2002-09-10 Scimed Life Systems, Inc. Atraumatic anchoring and disengagement mechanism for permanent implant device
US20020147462A1 (en) * 2000-09-11 2002-10-10 Closure Medical Corporation Bronchial occlusion method and apparatus
US6488673B1 (en) * 1997-04-07 2002-12-03 Broncus Technologies, Inc. Method of increasing gas exchange of a lung
US20030013935A1 (en) * 2001-07-10 2003-01-16 Spiration, Inc. Constriction device viewable under X ray fluoroscopy
US20030024527A1 (en) * 2001-08-03 2003-02-06 Integrated Vascular Systems, Inc. Lung assist apparatus and methods for use
US6527761B1 (en) * 2000-10-27 2003-03-04 Pulmonx, Inc. Methods and devices for obstructing and aspirating lung tissue segments
US20030050648A1 (en) * 2001-09-11 2003-03-13 Spiration, Inc. Removable lung reduction devices, systems, and methods
US20030070682A1 (en) * 2001-10-11 2003-04-17 Wilson Peter M. Bronchial flow control devices and methods of use
US20030083671A1 (en) * 2001-10-25 2003-05-01 Spiration, Inc. Bronchial obstruction device deployment system and method
US6558429B2 (en) * 1997-12-09 2003-05-06 Reflux Corporation Perorally insertable gastroesophageal anti-reflux valve prosthesis and tool for implantation thereof
US6585639B1 (en) * 2000-10-27 2003-07-01 Pulmonx Sheath and method for reconfiguring lung viewing scope
US20030154988A1 (en) * 2002-02-21 2003-08-21 Spiration, Inc. Intra-bronchial device that provides a medicant intra-bronchially to the patient
US20030158515A1 (en) * 2002-02-21 2003-08-21 Spiration, Inc. Device and method for intra-bronchial provision of a therapeutic agent
US20030167065A1 (en) * 2002-03-01 2003-09-04 Arvik Enterprises, Llc Blood vessel occlusion device
US20030180922A1 (en) * 1998-12-30 2003-09-25 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US6629951B2 (en) * 1999-08-05 2003-10-07 Broncus Technologies, Inc. Devices for creating collateral in the lungs
US20030195385A1 (en) * 2002-04-16 2003-10-16 Spiration, Inc. Removable anchored lung volume reduction devices and methods
US20030212412A1 (en) * 2002-05-09 2003-11-13 Spiration, Inc. Intra-bronchial obstructing device that permits mucus transport
US20040039250A1 (en) * 2002-05-28 2004-02-26 David Tholfsen Guidewire delivery of implantable bronchial isolation devices in accordance with lung treatment

Family Cites Families (342)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB324729A (en) 1928-11-07 1930-02-06 Ernst Berl Improved manufacture of activated carbon
US2115298A (en) 1937-04-16 1938-04-26 Roderick F Brown Suction tonsillectome
US2728225A (en) 1953-03-12 1955-12-27 Herbert E Skibitzke Thermal flowmeter
US3617060A (en) 1967-04-10 1971-11-02 Warren Iezzi Pneumothorox-inducing hunting arrow
US3889657A (en) 1974-02-12 1975-06-17 Gomco Surgical Mfg Co Uterine aspirating curette
US3962917A (en) 1974-07-03 1976-06-15 Minato Medical Science Co., Ltd. Respirometer having thermosensitive elements on both sides of a hot wire
JPS6010740Y2 (en) 1976-08-12 1985-04-11 アイダエンジニアリング株式会社 rotary clamper
US4056854A (en) 1976-09-28 1977-11-08 The United States Of America As Represented By The Department Of Health, Education And Welfare Aortic heart valve catheter
US4205282A (en) 1978-08-21 1980-05-27 Westinghouse Electric Corp. Phase shifting circuit element
US4267839A (en) 1979-09-12 1981-05-19 Repromed, Inc. Surgical instrument for use in reversible sterilization or permanent occlusion procedures
SU852321A1 (en) 1979-10-02 1981-08-07 Второй Московский Ордена Ленинагосударственный Медицинский Ин-Ститут Им. H.И.Пирогова Method of treating acute purulent diseases of lungs and pleura of children
US4301810A (en) 1980-02-29 1981-11-24 City Of Hope National Medical Center Ventilatory muscle training apparatus
US4393879A (en) 1980-04-11 1983-07-19 Milex Products, Inc. Tissue-collecting apparatus
US4483200A (en) 1981-01-19 1984-11-20 Anima Corporation Thermal pulse flowmeter
AU548370B2 (en) 1981-10-08 1985-12-05 United States Surgical Corporation Surgical fastener
JPS58163332U (en) 1982-04-27 1983-10-31 株式会社豊田自動織機製作所 Rear confirmation mirror device for forklift
US4888015A (en) 1982-08-20 1989-12-19 Domino Rudolph S Method of replacing an eye lens
US4654029A (en) 1982-12-13 1987-03-31 Howmedica, Inc. Electronic drainage system
FR2538705B1 (en) 1982-12-29 1987-12-31 Vincent Michel MEDICAL APPARATUS FOR THE EXSUFFLATION OF TIRES
US5669936A (en) 1983-12-09 1997-09-23 Endovascular Technologies, Inc. Endovascular grafting system and method for use therewith
US4601465A (en) 1984-03-22 1986-07-22 Roy Jean Yves Device for stimulating the human respiratory system
US4583541A (en) 1984-05-07 1986-04-22 Barry Joseph P Sternal stabilization device
US5135531A (en) 1984-05-14 1992-08-04 Surgical Systems & Instruments, Inc. Guided atherectomy system
US4610256A (en) 1984-09-25 1986-09-09 Utah Medical Products, Inc. Pressure transducer
US4685908A (en) 1984-10-18 1987-08-11 Bioresearch Ithaca Inc. Device for detecting increased pressure in pleural cavity
US4684363A (en) 1984-10-31 1987-08-04 American Hospital Supply Corporation Rapidly inflatable balloon catheter and method
US4881939A (en) 1985-02-19 1989-11-21 The Johns Hopkins University Implantable helical cuff
US4654027A (en) * 1985-10-30 1987-03-31 Dragan William B Vascular dilating device
US4682491A (en) 1986-02-19 1987-07-28 Pickard Murphy L Apparatus and method for testing prosthetic heart valves
FR2596978A1 (en) 1986-04-10 1987-10-16 Peters BONE FIXING PLATE, PROVIDED WITH SUTURE WIRES
US4745925A (en) * 1986-10-06 1988-05-24 Dietz Henry G Optoelectronic inhalation sensor for monitoring inhalation and for inhalation therapy
JPS63212028A (en) 1987-02-26 1988-09-05 Matsutani Seisakusho:Kk String fitting device for eyeless needle
FR2612597B1 (en) 1987-03-20 1989-06-23 Colon Jean VALVE HAS AT LEAST ONE TILT SHUTTER IN RELATION TO ELASTIC PIVOTS
US4794928A (en) 1987-06-10 1989-01-03 Kletschka Harold D Angioplasty device and method of using the same
US4852552A (en) 1987-09-03 1989-08-01 Pilling Co. Sternal retractor
US4936823A (en) * 1988-05-04 1990-06-26 Triangle Research And Development Corp. Transendoscopic implant capsule
US5002772A (en) 1988-05-31 1991-03-26 Pfizer Inc. Gastric retention system for controlled drug release
US4870975A (en) 1988-07-05 1989-10-03 Scott Cronk Suction canister assembly for the collection of body fluids and tissue specimens
US5556376A (en) 1988-07-22 1996-09-17 Yoon; Inbae Multifunctional devices having loop configured portions and collection systems for endoscopic surgical procedures and methods thereof
US4920978A (en) 1988-08-31 1990-05-01 Triangle Research And Development Corporation Method and apparatus for the endoscopic treatment of deep tumors using RF hyperthermia
JP2710355B2 (en) 1988-09-20 1998-02-10 日本ゼオン株式会社 Medical valve device
GB8822492D0 (en) 1988-09-24 1988-10-26 Considine J Apparatus for removing tumours from hollow organs of body
JPH0428596Y2 (en) 1989-02-07 1992-07-10
US5800339A (en) 1989-02-09 1998-09-01 Opticon Medical Inc. Urinary control valve
US5186711A (en) 1989-03-07 1993-02-16 Albert Einstein College Of Medicine Of Yeshiva University Hemostasis apparatus and method
US5135488A (en) 1989-03-17 1992-08-04 Merit Medical Systems, Inc. System and method for monitoring, displaying and recording balloon catheter inflation data
DK0474748T3 (en) 1989-05-31 1995-05-01 Baxter Int Biological flap prosthesis
US5562608A (en) 1989-08-28 1996-10-08 Biopulmonics, Inc. Apparatus for pulmonary delivery of drugs with simultaneous liquid lavage and ventilation
US5019086A (en) 1989-09-12 1991-05-28 Neward Theodore C Manipulable vacuum extractor for childbirth and method of using the same
US4995872A (en) 1989-10-04 1991-02-26 Ferrara Janice J Expandable catheter and bridge device
US5797907A (en) 1989-11-06 1998-08-25 Mectra Labs, Inc. Electrocautery cutter
US5174283A (en) 1989-11-08 1992-12-29 Parker Jeffrey D Blind orolaryngeal and oroesophageal guiding and aiming device
US5516336A (en) 1990-02-07 1996-05-14 Advanced Cardiovascular Systems, Inc. Readily exchangeable perfusion dilatation catheter
US5514153A (en) 1990-03-02 1996-05-07 General Surgical Innovations, Inc. Method of dissecting tissue layers
US5127412A (en) 1990-03-14 1992-07-07 Cosmetto Aristodeme J Skin tensioning
US5593413A (en) 1990-05-14 1997-01-14 Medisys Technologies, Inc. Device for assisting childbirth
US5411552A (en) 1990-05-18 1995-05-02 Andersen; Henning R. Valve prothesis for implantation in the body and a catheter for implanting such valve prothesis
DK124690D0 (en) 1990-05-18 1990-05-18 Henning Rud Andersen FAT PROTECTION FOR IMPLEMENTATION IN THE BODY FOR REPLACEMENT OF NATURAL FLEET AND CATS FOR USE IN IMPLEMENTING A SUCH FAT PROTECTION
US5111828A (en) 1990-09-18 1992-05-12 Peb Biopsy Corporation Device for percutaneous excisional breast biopsy
WO1992010725A1 (en) 1990-12-11 1992-06-25 Abbey Biosystems Limited Hot wire anemometer
US5059208A (en) 1991-02-04 1991-10-22 Helix Medical, Inc. Adjustable tracheostoma valve
US5226429A (en) 1991-06-20 1993-07-13 Inamed Development Co. Laparoscopic gastric band and method
US5147369A (en) 1991-07-01 1992-09-15 Wagner Michael A Forceps and method for nuclear fragment removal
US5171299A (en) 1991-08-02 1992-12-15 Baxter International Inc. Balloon catheter inflation pressure and diameter display apparatus and method
US5163944A (en) 1991-08-09 1992-11-17 Neward Theodore C Obstetrical vacuum extractor
US5207702A (en) 1991-08-14 1993-05-04 Pearl Michael L Method and apparatus for handling hygroscopic dilators
US5662713A (en) 1991-10-09 1997-09-02 Boston Scientific Corporation Medical stents for body lumens exhibiting peristaltic motion
US5876445A (en) 1991-10-09 1999-03-02 Boston Scientific Corporation Medical stents for body lumens exhibiting peristaltic motion
US5197485A (en) 1991-10-15 1993-03-30 Pilling Co. Method and apparatus for sampling aortic plaque
US5741271A (en) 1991-11-05 1998-04-21 Nakao; Naomi L. Surgical retrieval assembly and associated method
US5197963A (en) 1991-12-02 1993-03-30 Everest Medical Corporation Electrosurgical instrument with extendable sheath for irrigation and aspiration
IT1253903B (en) 1991-12-05 1995-08-31 Luigi Gigante VALVE CATHETER FOR INCONTINENCE AND URINARY RETENTION
US5626605A (en) * 1991-12-30 1997-05-06 Scimed Life Systems, Inc. Thrombosis filter
US5255687A (en) 1992-01-21 1993-10-26 Mckenna Charles L Zero dead space respiratory exercise valve
JP3393383B2 (en) 1992-01-21 2003-04-07 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ Septal defect closure device
US5342298A (en) 1992-07-31 1994-08-30 Advanced Cardiovascular Systems, Inc. Automated fluid pressure control system
FR2696092B1 (en) 1992-09-28 1994-12-30 Lefebvre Jean Marie Kit for medical use composed of a filter and its device for placement in the vessel.
US5356412A (en) 1992-10-09 1994-10-18 United States Surgical Corporation Sternum buckle with rotational engagement and method of closure
US5643317A (en) 1992-11-25 1997-07-01 William Cook Europe S.A. Closure prosthesis for transcatheter placement
US5366475A (en) 1992-12-21 1994-11-22 Shatzu Health Products, Inc. Tragus acupressure clip
DE4300285A1 (en) 1993-01-08 1994-07-14 Wolf Gmbh Richard Instrument for implanting and extracting stents
JPH0819544B2 (en) 1993-02-05 1996-02-28 協和電線株式会社 Lead steel wire for electronic parts and manufacturing method thereof
WO1994026175A1 (en) 1993-05-06 1994-11-24 Vitaphore Corporation Embolization device
US5486154A (en) 1993-06-08 1996-01-23 Kelleher; Brian S. Endoscope
US5423830A (en) 1993-07-07 1995-06-13 Schneebaum; Cary W. Polyp retrieval method and associated instrument assembly
US5507754A (en) 1993-08-20 1996-04-16 United States Surgical Corporation Apparatus and method for applying and adjusting an anchoring device
EP0722286B1 (en) 1993-09-20 2002-08-21 Boston Scientific Corporation Multiple biopsy sampling device
US5542594A (en) 1993-10-06 1996-08-06 United States Surgical Corporation Surgical stapling apparatus with biocompatible surgical fabric
US5456689A (en) 1993-10-13 1995-10-10 Arnold J. Kresch Method and device for tissue resection
US5957672A (en) 1993-11-10 1999-09-28 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Blood pump bearing system
US5490860A (en) 1993-12-08 1996-02-13 Sofamor Danek Properties, Inc. Portable power cutting tool
US5415658A (en) 1993-12-14 1995-05-16 Pioneer Laboratories, Inc. Surgical cable loop connector
US5772583A (en) 1994-01-21 1998-06-30 Wright; John T. M. Sternal retractor with attachments for mitral & tricuspid valve repair
US5398844A (en) 1994-01-31 1995-03-21 Boston Scientific Corporation Multiple ligating band dispenser
US5871453A (en) 1994-02-08 1999-02-16 Boston Scientific Corporation Moveable sample tube multiple biopsy sampling device
US5503638A (en) 1994-02-10 1996-04-02 Bio-Vascular, Inc. Soft tissue stapling buttress
US5411016A (en) 1994-02-22 1995-05-02 Scimed Life Systems, Inc. Intravascular balloon catheter for use in combination with an angioscope
US5499995C1 (en) 1994-05-25 2002-03-12 Paul S Teirstein Body passageway closure apparatus and method of use
US5824041A (en) * 1994-06-08 1998-10-20 Medtronic, Inc. Apparatus and methods for placement and repositioning of intraluminal prostheses
US5683451A (en) 1994-06-08 1997-11-04 Cardiovascular Concepts, Inc. Apparatus and methods for deployment release of intraluminal prostheses
US5417226A (en) 1994-06-09 1995-05-23 Juma; Saad Female anti-incontinence device
US6056744A (en) 1994-06-24 2000-05-02 Conway Stuart Medical, Inc. Sphincter treatment apparatus
US6062575A (en) 1994-07-27 2000-05-16 Mednext, Inc. Tool shaft coupler
US5575293A (en) 1995-02-06 1996-11-19 Promex, Inc. Apparatus for collecting and staging tissue
US6083141A (en) 1995-02-10 2000-07-04 Hougen; Everett D. Portable respiratory exercise apparatus and method for using the same
US5662622A (en) 1995-04-04 1997-09-02 Cordis Corporation Intravascular catheter
US5676671A (en) 1995-04-12 1997-10-14 Inoue; Kanji Device for introducing an appliance to be implanted into a catheter
US5752522A (en) * 1995-05-04 1998-05-19 Cardiovascular Concepts, Inc. Lesion diameter measurement catheter and method
DE29507519U1 (en) 1995-05-05 1995-08-10 Angiomed Ag Endosphincter and set for releasable closing of the urethra
US5681347A (en) 1995-05-23 1997-10-28 Boston Scientific Corporation Vena cava filter delivery system
WO1996037167A1 (en) 1995-05-25 1996-11-28 Raychem Corporation Stent assembly
US5704910A (en) * 1995-06-05 1998-01-06 Nephros Therapeutics, Inc. Implantable device and use therefor
US6312407B1 (en) 1995-06-05 2001-11-06 Medtronic Percusurge, Inc. Occlusion of a vessel
US5645565A (en) 1995-06-13 1997-07-08 Ethicon Endo-Surgery, Inc. Surgical plug
EP0861048A4 (en) 1995-07-03 2000-05-17 Dirk A Frater System for mounting bolster material on tissue staplers
US5766134A (en) 1995-07-18 1998-06-16 Atrion Medical Products, Inc. Autogenous bone specimen collector
US5810855A (en) 1995-07-21 1998-09-22 Gore Enterprise Holdings, Inc. Endoscopic device and method for reinforcing surgical staples
US5702409A (en) 1995-07-21 1997-12-30 W. L. Gore & Associates, Inc. Device and method for reinforcing surgical staples
US5697968A (en) 1995-08-10 1997-12-16 Aeroquip Corporation Check valve for intraluminal graft
US5660175A (en) 1995-08-21 1997-08-26 Dayal; Bimal Endotracheal device
US5817034A (en) 1995-09-08 1998-10-06 United States Surgical Corporation Apparatus and method for removing tissue
EP0955933B1 (en) 1995-10-13 2009-08-26 Medtronic Vascular, Inc. A device for interstitial transvascular intervention
US6146384A (en) 1995-10-13 2000-11-14 Sdgi Holdings, Inc. Orthopedic fixation device and method of implantation
CA2242861A1 (en) 1996-01-11 1997-07-17 Bruce H. Diamond Flexible microsurgical instruments incorporating a sheath having tactile and visual position indicators
EP1011889B1 (en) 1996-01-30 2002-10-30 Medtronic, Inc. Articles for and methods of making stents
US6258083B1 (en) * 1996-03-29 2001-07-10 Eclipse Surgical Technologies, Inc. Viewing surgical scope for minimally invasive procedures
US5980545A (en) 1996-05-13 1999-11-09 United States Surgical Corporation Coring device and method
US6958059B2 (en) 1996-05-20 2005-10-25 Medtronic Ave, Inc. Methods and apparatuses for drug delivery to an intravascular occlusion
US6050972A (en) 1996-05-20 2000-04-18 Percusurge, Inc. Guidewire inflation system
US6152909A (en) 1996-05-20 2000-11-28 Percusurge, Inc. Aspiration system and method
US20050245894A1 (en) 1996-05-20 2005-11-03 Medtronic Vascular, Inc. Methods and apparatuses for drug delivery to an intravascular occlusion
US6325777B1 (en) 1996-05-20 2001-12-04 Medtronic Percusurge, Inc. Low profile catheter valve and inflation adaptor
JP3690815B2 (en) 1996-05-20 2005-08-31 メドトロニック パークサージ インコーポレイテッド Small section catheter
EP0808614B1 (en) 1996-05-23 2003-02-26 Samsung Electronics Co., Ltd. Flexible self-expandable stent and method for making the same
SE9602226D0 (en) 1996-06-05 1996-06-05 Astra Ab Biocompatible glue
KR980000327U (en) 1996-06-13 1998-03-30 이정행 Earring hole molding for earring installation
WO1998000840A1 (en) 1996-06-28 1998-01-08 Samsung Electronics Co., Ltd. Thin film magnetic head tip and manufacturing method therefor
IT1284108B1 (en) 1996-07-04 1998-05-08 Carlo Rebuffat SURGICAL PRESIDIUM FOR THE TREATMENT OF PULMONARY EMPHYSEMA
US6077295A (en) 1996-07-15 2000-06-20 Advanced Cardiovascular Systems, Inc. Self-expanding stent delivery system
US5669933A (en) 1996-07-17 1997-09-23 Nitinol Medical Technologies, Inc. Removable embolus blood clot filter
US6102885A (en) 1996-08-08 2000-08-15 Bass; Lawrence S. Device for suction-assisted lipectomy and method of using same
US5782916A (en) * 1996-08-13 1998-07-21 Galt Laboratories, Inc. Device for maintaining urinary continence
US5810806A (en) 1996-08-29 1998-09-22 Ethicon Endo-Surgery Methods and devices for collection of soft tissue
US5725519A (en) 1996-09-30 1998-03-10 Medtronic Instent Israel Ltd. Stent loading device for a balloon catheter
US5895387A (en) 1996-10-09 1999-04-20 Romulo Guerrero Method of craniofacial bone distraction
US5752965A (en) 1996-10-21 1998-05-19 Bio-Vascular, Inc. Apparatus and method for producing a reinforced surgical fastener suture line
US5769892A (en) 1996-10-22 1998-06-23 Mitroflow International Inc. Surgical stapler sleeve for reinforcing staple lines
US5893867A (en) 1996-11-06 1999-04-13 Percusurge, Inc. Stent positioning apparatus and method
US6102926A (en) 1996-12-02 2000-08-15 Angiotrax, Inc. Apparatus for percutaneously performing myocardial revascularization having means for sensing tissue parameters and methods of use
US5779649A (en) 1996-12-17 1998-07-14 Pabban Development, Inc. Surgical suction wand with filter
EP0850607A1 (en) 1996-12-31 1998-07-01 Cordis Corporation Valve prosthesis for implantation in body channels
US6077214A (en) 1998-07-29 2000-06-20 Myocor, Inc. Stress reduction apparatus and method
US5810809A (en) 1997-01-13 1998-09-22 Enhanced Orthopaedic Technologies, Inc. Arthroscopic shaver incorporating electrocautery
US5919224A (en) * 1997-02-12 1999-07-06 Schneider (Usa) Inc Medical device having a constricted region for occluding fluid flow in a body lumen
US6508825B1 (en) 1997-02-28 2003-01-21 Lumend, Inc. Apparatus for treating vascular occlusions
AU6688398A (en) 1997-03-06 1998-09-22 Percusurge, Inc. Intravascular aspiration system
US5817101A (en) 1997-03-13 1998-10-06 Schneider (Usa) Inc Fluid actuated stent delivery system
US6411852B1 (en) 1997-04-07 2002-06-25 Broncus Technologies, Inc. Modification of airways by application of energy
US6283988B1 (en) 1997-04-07 2001-09-04 Broncus Technologies, Inc. Bronchial stenter having expandable electrodes
US6083255A (en) 1997-04-07 2000-07-04 Broncus Technologies, Inc. Bronchial stenter
US6200333B1 (en) * 1997-04-07 2001-03-13 Broncus Technologies, Inc. Bronchial stenter
US6634363B1 (en) 1997-04-07 2003-10-21 Broncus Technologies, Inc. Methods of treating lungs having reversible obstructive pulmonary disease
US6273907B1 (en) 1997-04-07 2001-08-14 Broncus Technologies, Inc. Bronchial stenter
GB2324729B (en) 1997-04-30 2002-01-02 Bradford Hospitals Nhs Trust Lung treatment device
US5957949A (en) 1997-05-01 1999-09-28 World Medical Manufacturing Corp. Percutaneous placement valve stent
US6245102B1 (en) 1997-05-07 2001-06-12 Iowa-India Investments Company Ltd. Stent, stent graft and stent valve
US5855597A (en) 1997-05-07 1999-01-05 Iowa-India Investments Co. Limited Stent valve and stent graft for percutaneous surgery
US6162245A (en) 1997-05-07 2000-12-19 Iowa-India Investments Company Limited Stent valve and stent graft
US5976158A (en) 1997-06-02 1999-11-02 Boston Scientific Corporation Method of using a textured ligating band
US6007575A (en) 1997-06-06 1999-12-28 Samuels; Shaun Laurence Wilkie Inflatable intraluminal stent and method for affixing same within the human body
US5957919A (en) 1997-07-02 1999-09-28 Laufer; Michael D. Bleb reducer
US6626903B2 (en) 1997-07-24 2003-09-30 Rex Medical, L.P. Surgical biopsy device
US6010525A (en) 1997-08-01 2000-01-04 Peter M. Bonutti Method and apparatus for securing a suture
US5984965A (en) 1997-08-28 1999-11-16 Urosurge, Inc. Anti-reflux reinforced stent
US6322522B1 (en) 1997-09-22 2001-11-27 Zimmon Science Corp. Apparatus for separable external serial collection, storage and processing of biopsy specimens
US5976174A (en) 1997-12-15 1999-11-02 Ruiz; Carlos E. Medical hole closure device and methods of use
FR2773702B1 (en) 1998-01-16 2000-04-07 Johnson & Johnson Internationa COMPRESSION DEVICE FOR HEMOSTASIS OF AN ORGAN, SUCH AS LIVER
US7879022B2 (en) 1998-02-06 2011-02-01 Medrad, Inc. Rapid exchange fluid jet thrombectomy device and method
US5944738A (en) 1998-02-06 1999-08-31 Aga Medical Corporation Percutaneous catheter directed constricting occlusion device
US20010016704A1 (en) 1998-02-19 2001-08-23 Gholam Reza Zadno-Azizi Low profile fluid delivery and sealing system for a catheter
US6544192B2 (en) * 1998-02-25 2003-04-08 Respironics, Inc. Patient monitor and method of using same
US6454727B1 (en) 1998-03-03 2002-09-24 Senorx, Inc. Tissue acquisition system and method of use
EP0941713B1 (en) 1998-03-04 2004-11-03 Schneider (Europe) GmbH Device to insert an endoprosthesis into a catheter shaft
US6995675B2 (en) * 1998-03-09 2006-02-07 Curkendall Leland D Method and system for agricultural data collection and management
US6099551A (en) 1998-03-12 2000-08-08 Shelhigh, Inc. Pericardial strip and stapler assembly for dividing and sealing visceral tissues and method of use thereof
US5925060A (en) 1998-03-13 1999-07-20 B. Braun Celsa Covered self-expanding vascular occlusion device
US6911028B2 (en) 1998-10-28 2005-06-28 John H. Shadduck Medical instrument working end and method for endoluminal treatments
US5972009A (en) 1998-04-07 1999-10-26 Boston Scientific Corporation Ligating band with rounded edges and method of use of same
US6009614A (en) 1998-04-21 2000-01-04 Advanced Cardiovascular Systems, Inc. Stent crimping tool and method of use
US6141855A (en) 1998-04-28 2000-11-07 Advanced Cardiovascular Systems, Inc. Stent crimping tool and method of use
US6003517A (en) 1998-04-30 1999-12-21 Ethicon Endo-Surgery, Inc. Method for using an electrosurgical device on lung tissue
US5974652A (en) 1998-05-05 1999-11-02 Advanced Cardiovascular Systems, Inc. Method and apparatus for uniformly crimping a stent onto a catheter
US6493589B1 (en) 1998-05-07 2002-12-10 Medtronic, Inc. Methods and apparatus for treatment of pulmonary conditions
US6327505B1 (en) 1998-05-07 2001-12-04 Medtronic, Inc. Method and apparatus for rf intraluminal reduction and occlusion
US6024759A (en) 1998-05-08 2000-02-15 Walter Lorenz Surgical, Inc. Method and apparatus for performing pectus excavatum repair
US6132458A (en) 1998-05-15 2000-10-17 American Medical Systems, Inc. Method and device for loading a stent
US6599311B1 (en) 1998-06-05 2003-07-29 Broncus Technologies, Inc. Method and assembly for lung volume reduction
WO2002032334A1 (en) 2000-10-17 2002-04-25 Broncus Technologies, Inc. Modification of airways by application of energy
US6086543A (en) 1998-06-24 2000-07-11 Rubicor Medical, Inc. Fine needle and core biopsy devices and methods
JP2920188B1 (en) 1998-06-26 1999-07-19 日新電機株式会社 Pulse bias hydrogen negative ion implantation method and implantation apparatus
US6296639B1 (en) 1999-02-12 2001-10-02 Novacept Apparatuses and methods for interstitial tissue removal
US6264700B1 (en) 1998-08-27 2001-07-24 Endonetics, Inc. Prosthetic gastroesophageal valve
IL125965A (en) 1998-08-27 2003-03-12 Hendler Shoshan Apparatus and method for acquisition and retrieval of resected biological specimens
US6342062B1 (en) 1998-09-24 2002-01-29 Scimed Life Systems, Inc. Retrieval devices for vena cava filter
US6331183B1 (en) 1998-09-24 2001-12-18 Scimed Life Systems, Inc. Basket filter
US6096027A (en) 1998-09-30 2000-08-01 Impra, Inc., A Subsidiary Of C.R. Bard, Inc. Bag enclosed stent loading apparatus
US6270527B1 (en) 1998-10-16 2001-08-07 Sulzer Carbomedics Inc. Elastic valve with partially exposed stent
RU2140211C1 (en) 1998-10-28 1999-10-27 Российская медицинская академия последипломного образования Министерства здравоохранения Российской Федерации Method of surgical treatment of patients with pathology of respiratory organs complicated with pulmonary hemorrhages
US6500165B1 (en) 1998-10-29 2002-12-31 Steven R. Frank Active antisepsis device
US6020380A (en) 1998-11-25 2000-02-01 Tap Holdings Inc. Method of treating chronic obstructive pulmonary disease
US6051022A (en) 1998-12-30 2000-04-18 St. Jude Medical, Inc. Bileaflet valve having non-parallel pivot axes
ATE379998T1 (en) 1999-01-26 2007-12-15 Edwards Lifesciences Corp FLEXIBLE HEART VALVE
US6425916B1 (en) 1999-02-10 2002-07-30 Michi E. Garrison Methods and devices for implanting cardiac valves
US6090041A (en) 1999-02-16 2000-07-18 Regents Of The University Of California vacuum actuated surgical retractor and methods
FR2789889B1 (en) 1999-02-18 2001-04-27 Tokendo Sarl SYSTEM FOR LAYING SEMI-RIGID TUBULAR ENDOPROSTHESES
US6090035A (en) 1999-03-19 2000-07-18 Isostent, Inc. Stent loading assembly for a self-expanding stent
US6231589B1 (en) * 1999-03-22 2001-05-15 Microvena Corporation Body vessel filter
US6206918B1 (en) * 1999-05-12 2001-03-27 Sulzer Carbomedics Inc. Heart valve prosthesis having a pivot design for improving flow characteristics
US6168617B1 (en) * 1999-06-14 2001-01-02 Scimed Life Systems, Inc. Stent delivery system
WO2000078407A1 (en) 1999-06-18 2000-12-28 Powerlung Inc Pulmonary exercise device
US6146388A (en) 1999-06-21 2000-11-14 Surgical Concepts, Inc. Rocking apparatus for manipulating element in the eye
US6234996B1 (en) 1999-06-23 2001-05-22 Percusurge, Inc. Integrated inflation/deflation device and method
US6997951B2 (en) * 1999-06-30 2006-02-14 Edwards Lifesciences Ag Method and device for treatment of mitral insufficiency
US6174331B1 (en) 1999-07-19 2001-01-16 Sulzer Carbomedics Inc. Heart valve leaflet with reinforced free margin
US7422584B2 (en) 2002-07-05 2008-09-09 Broncus Technologies, Inc. Extrapleural airway device and method
US7175644B2 (en) 2001-02-14 2007-02-13 Broncus Technologies, Inc. Devices and methods for maintaining collateral channels in tissue
US6709427B1 (en) 1999-08-05 2004-03-23 Kensey Nash Corporation Systems and methods for delivering agents into targeted tissue of a living being
US6712812B2 (en) 1999-08-05 2004-03-30 Broncus Technologies, Inc. Devices for creating collateral channels
US6749606B2 (en) * 1999-08-05 2004-06-15 Thomas Keast Devices for creating collateral channels
US8257428B2 (en) 1999-08-09 2012-09-04 Cardiokinetix, Inc. System for improving cardiac function
WO2001012104A1 (en) 1999-08-13 2001-02-22 Percusurge, Inc. Occlusion of a vessel
ES2272225T3 (en) 1999-08-24 2007-05-01 Spiration, Inc. LUNG VOLUME REDUCTION KIT.
US6416554B1 (en) 1999-08-24 2002-07-09 Spiration, Inc. Lung reduction apparatus and method
AUPQ254199A0 (en) 1999-08-31 1999-09-23 University Of Western Australia, The Methods and devices for obtaining samples from hollow viscera
US6203551B1 (en) * 1999-10-04 2001-03-20 Advanced Cardiovascular Systems, Inc. Chamber for applying therapeutic substances to an implant device
US6280398B1 (en) 1999-10-18 2001-08-28 Ethicon Endo-Surgery Methods and devices for collection of soft tissue
US6402754B1 (en) * 1999-10-20 2002-06-11 Spiration, Inc. Apparatus for expanding the thorax
US6551303B1 (en) 1999-10-27 2003-04-22 Atritech, Inc. Barrier device for ostium of left atrial appendage
US6702802B1 (en) 1999-11-10 2004-03-09 Endovascular Technologies, Inc. Catheters with improved transition
US6458153B1 (en) 1999-12-31 2002-10-01 Abps Venture One, Ltd. Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof
US6383198B1 (en) 1999-12-07 2002-05-07 Scimed Life System, Inc. Flexible vacuum grabber for holding lesions
AU2736901A (en) 1999-12-23 2001-07-03 Percusurge, Inc. Strut design for an occlusion device
US6510846B1 (en) 1999-12-23 2003-01-28 O'rourke Sam Sealed back pressure breathing device
US6277083B1 (en) 1999-12-27 2001-08-21 Neothermia Corporation Minimally invasive intact recovery of tissue
US6471979B2 (en) 1999-12-29 2002-10-29 Estrogen Vascular Technology, Llc Apparatus and method for delivering compounds to a living organism
NL1014095C2 (en) 2000-01-17 2001-07-18 Cornelis Hendrikus Anna Witten Implant valve for implantation into a blood vessel.
AU2001228653A1 (en) 2000-01-24 2001-07-31 Biocompatibles Limited Coated implants
JP2004507444A (en) 2000-01-31 2004-03-11 ジェネーラ コーポレーション Mucin synthesis inhibitor
DK1255510T5 (en) 2000-01-31 2009-12-21 Cook Biotech Inc Stent Valve Klapper
US6458076B1 (en) 2000-02-01 2002-10-01 5 Star Medical Multi-lumen medical device
WO2001056512A1 (en) * 2000-02-02 2001-08-09 Snyders Robert V Artificial heart valve
US6399366B1 (en) 2000-02-07 2002-06-04 Eric Seagren Method and apparatus for composting organic waste together with its packaging cartons, boxes or crates on site
US6540767B1 (en) 2000-02-08 2003-04-01 Scimed Life Systems, Inc. Recoilable thrombosis filtering device and method
US20030070683A1 (en) 2000-03-04 2003-04-17 Deem Mark E. Methods and devices for use in performing pulmonary procedures
US6770070B1 (en) 2000-03-17 2004-08-03 Rita Medical Systems, Inc. Lung treatment apparatus and method
WO2001074271A1 (en) 2000-03-31 2001-10-11 Broncus Technologies, Inc. Lung elastic recoil restoring/compression device
US6514290B1 (en) * 2000-03-31 2003-02-04 Broncus Technologies, Inc. Lung elastic recoil restoring or tissue compressing device and method
GB2369575A (en) * 2000-04-20 2002-06-05 Salviac Ltd An embolic protection system
US20030164168A1 (en) 2000-05-18 2003-09-04 Shaw David Peter Bronchiopulmonary occulsion devices and lung volume reduction methods
US6722360B2 (en) * 2000-06-16 2004-04-20 Rajiv Doshi Methods and devices for improving breathing in patients with pulmonary disease
US6695878B2 (en) 2000-06-26 2004-02-24 Rex Medical, L.P. Vascular device for valve leaflet apposition
US6568387B2 (en) * 2000-07-19 2003-05-27 University Of Florida Method for treating chronic obstructive pulmonary disorder
US7862500B2 (en) 2002-08-01 2011-01-04 Cardiokinetix, Inc. Multiple partitioning devices for heart treatment
US6485436B1 (en) 2000-08-10 2002-11-26 Csaba Truckai Pressure-assisted biopsy needle apparatus and technique
US6945989B1 (en) 2000-09-18 2005-09-20 Endotex Interventional Systems, Inc. Apparatus for delivering endoluminal prostheses and methods of making and using them
JP2004510524A (en) 2000-10-12 2004-04-08 メドトロニック バスキュラー インコーポレイテッド Method and apparatus for protecting a proximal end of a medical device
US6540694B1 (en) 2000-10-16 2003-04-01 Sanarus Medical, Inc. Device for biopsy tumors
US7077851B2 (en) 2000-10-17 2006-07-18 Aesculap Ag & Co. Kg Aneurysm clip
JP4064243B2 (en) 2000-11-06 2008-03-19 スルーズ サージカル システムズ、インク Biological tissue examination device
US6840952B2 (en) 2000-12-07 2005-01-11 Mark B. Saker Tissue tract sealing device
US20040093075A1 (en) 2000-12-15 2004-05-13 Titus Kuehne Stent with valve and method of use thereof
US6620095B2 (en) 2000-12-22 2003-09-16 Syde A. Taheri Cradle-assisted myocardial repair and treatment
US6653525B2 (en) 2001-01-18 2003-11-25 The Brigham And Women's Hospital, Inc. Prosthetic device for respiratory patients
US6494884B2 (en) 2001-02-09 2002-12-17 Concentric Medical, Inc. Methods and devices for delivering occlusion elements
US6666862B2 (en) 2001-03-01 2003-12-23 Cardiac Pacemakers, Inc. Radio frequency ablation system and method linking energy delivery with fluid flow
US7011094B2 (en) * 2001-03-02 2006-03-14 Emphasys Medical, Inc. Bronchial flow control devices and methods of use
US6503272B2 (en) * 2001-03-21 2003-01-07 Cordis Corporation Stent-based venous valves
US6638285B2 (en) 2001-04-16 2003-10-28 Shlomo Gabbay Biological tissue strip and system and method to seal tissue
US6491706B1 (en) 2001-07-10 2002-12-10 Spiration, Inc. Constriction device including fixation structure
JP4602602B2 (en) * 2001-07-19 2010-12-22 オリンパス株式会社 Medical instruments
US20030018327A1 (en) * 2001-07-20 2003-01-23 Csaba Truckai Systems and techniques for lung volume reduction
US6902540B2 (en) 2001-08-22 2005-06-07 Gerald Dorros Apparatus and methods for treating stroke and controlling cerebral flow characteristics
US6589240B2 (en) 2001-08-28 2003-07-08 Rex Medical, L.P. Tissue biopsy apparatus with collapsible cutter
US20050137611A1 (en) 2001-09-04 2005-06-23 Broncus Technologies, Inc. Methods and devices for maintaining surgically created channels in a body organ
EP1435833B1 (en) * 2001-09-10 2014-05-21 Pulmonx Apparatus for endobronchial diagnosis
WO2003022134A2 (en) * 2001-09-11 2003-03-20 Pulmonx Methods of endobronchial diagnosis using imaging
US6632239B2 (en) 2001-10-02 2003-10-14 Spiration, Inc. Constriction device including reinforced suture holes
US6893460B2 (en) 2001-10-11 2005-05-17 Percutaneous Valve Technologies Inc. Implantable prosthetic valve
US20030083730A1 (en) 2001-10-25 2003-05-01 Scimed Life Systems, Inc. Loading cartridge for self-expanding stent
US6682250B2 (en) * 2001-11-07 2004-01-27 Lockheed Martin Corporation Position-adjustable fastening apparatus and method
US20030127090A1 (en) 2001-11-14 2003-07-10 Emphasys Medical, Inc. Active pump bronchial implant devices and methods of use thereof
US6668832B2 (en) 2001-12-28 2003-12-30 The Regents Of The University Of California Endotracheal tube
US6695791B2 (en) 2002-01-04 2004-02-24 Spiration, Inc. System and method for capturing body tissue samples
US20060235432A1 (en) 2002-02-21 2006-10-19 Devore Lauri J Intra-bronchial obstructing device that controls biological interaction with the patient
WO2003075796A2 (en) 2002-03-08 2003-09-18 Emphasys Medical, Inc. Methods and devices for inducing collapse in lung regions fed by collateral pathways
AU2003225755A1 (en) 2002-03-11 2003-09-29 Aeris Therapeutics, Inc. Compositions and methods for treating emphysema
JP4465192B2 (en) 2002-03-15 2010-05-19 エヌエムティー メディカル, インコーポレイティッド A binding system useful in implant placement
US20030181922A1 (en) 2002-03-20 2003-09-25 Spiration, Inc. Removable anchored lung volume reduction devices and methods
WO2003079944A1 (en) 2002-03-20 2003-10-02 Spiration, Inc. Removable anchored lung volume reduction devices and methods
US20030216769A1 (en) 2002-05-17 2003-11-20 Dillard David H. Removable anchored lung volume reduction devices and methods
US20030181890A1 (en) 2002-03-22 2003-09-25 Schulze Dale R. Medical device that removably attaches to a bodily organ
CA2482935A1 (en) 2002-04-19 2003-10-30 Broncus Technologies, Inc. Devices for maintaining surgically created openings
US7207946B2 (en) 2002-05-09 2007-04-24 Spiration, Inc. Automated provision of information related to air evacuation from a chest cavity
US6852108B2 (en) 2002-05-14 2005-02-08 Spiration, Inc. Apparatus and method for resecting and removing selected body tissue from a site inside a patient
US20040059263A1 (en) 2002-09-24 2004-03-25 Spiration, Inc. Device and method for measuring the diameter of an air passageway
US20040010209A1 (en) 2002-07-15 2004-01-15 Spiration, Inc. Device and method for measuring the diameter of an air passageway
EP1524942B1 (en) 2002-07-26 2008-09-10 Emphasys Medical, Inc. Bronchial flow control devices with membrane seal
US7086398B2 (en) 2002-07-31 2006-08-08 Cordis Corporation Long term oxygen therapy system
US6886558B2 (en) 2002-08-28 2005-05-03 Cordis Corporation Collateral ventilation bypass trap system
US6849084B2 (en) 2002-12-31 2005-02-01 Intek Technology L.L.C. Stent delivery system
US20040210248A1 (en) 2003-03-12 2004-10-21 Spiration, Inc. Apparatus, method and assembly for delivery of intra-bronchial devices
US7637934B2 (en) 2003-03-31 2009-12-29 Merit Medical Systems, Inc. Medical appliance optical delivery and deployment apparatus and method
US7100616B2 (en) 2003-04-08 2006-09-05 Spiration, Inc. Bronchoscopic lung volume reduction method
JP4272654B2 (en) 2003-04-11 2009-06-03 Hoya株式会社 Chromium-based thin film etching method and photomask manufacturing method
US7530995B2 (en) 2003-04-17 2009-05-12 3F Therapeutics, Inc. Device for reduction of pressure effects of cardiac tricuspid valve regurgitation
US7252086B2 (en) 2003-06-03 2007-08-07 Cordis Corporation Lung reduction system
US7533671B2 (en) 2003-08-08 2009-05-19 Spiration, Inc. Bronchoscopic repair of air leaks in a lung
US20050080434A1 (en) 2003-10-08 2005-04-14 Cedars-Sinai Medical Center Laparoscopic retractable dissector and suture and needle passer
US7273469B1 (en) 2003-12-31 2007-09-25 Advanced Cardiovascular Systems, Inc. Modified needle catheter for directional orientation delivery
US7704268B2 (en) 2004-05-07 2010-04-27 Nmt Medical, Inc. Closure device with hinges
EP1789123A4 (en) 2004-09-17 2010-03-03 Cordis Neurovascular Inc Thin film metallic devices for plugging aneurysms or vessels
EP1656963B1 (en) 2004-11-10 2007-11-21 Creganna Technologies Limited Stent delivery catheter assembly
ES2645340T3 (en) 2004-11-16 2017-12-05 Uptake Medical Technology Inc. Lung treatment device
US7771472B2 (en) 2004-11-19 2010-08-10 Pulmonx Corporation Bronchial flow control devices and methods of use
SE531468C2 (en) 2005-04-21 2009-04-14 Edwards Lifesciences Ag An apparatus for controlling blood flow
CA2608355A1 (en) 2005-05-13 2006-11-23 Alveolus, Inc. Delivery device allowing visual inspection of an intraluminal device
US20070209204A1 (en) 2006-03-09 2007-09-13 Chase Daniel J Hose Assembly Process, Device, and Product-by-Process
US7691151B2 (en) 2006-03-31 2010-04-06 Spiration, Inc. Articulable Anchor
DE102006061344A1 (en) 2006-12-22 2008-06-26 Robert Bosch Gmbh Clutch hydraulic circuit
JP2008194250A (en) 2007-02-14 2008-08-28 Piolax Medical Device:Kk Delivery tool of tubular organ treatment instrument
US8247019B2 (en) 2007-04-25 2012-08-21 Harland Medical Systems, Inc. Coating sleeve
US7606625B2 (en) 2007-06-15 2009-10-20 Abbott Cardiovascular Systems Inc. Method and device for aligning a stent with a stent support
US20090188508A1 (en) 2007-09-14 2009-07-30 Smith Jr A James Disposable medical mouthpiece appliance
US8043301B2 (en) 2007-10-12 2011-10-25 Spiration, Inc. Valve loader method, system, and apparatus
US8136230B2 (en) 2007-10-12 2012-03-20 Spiration, Inc. Valve loader method, system, and apparatus
AU2009242611A1 (en) 2008-05-01 2009-11-05 Spiration, Inc. Direct lung sensor systems, methods, and apparatuses
AU2009289474B2 (en) 2008-09-04 2015-09-03 Curaseal Inc. Inflatable devices for enteric fistula treatment
WO2010040009A1 (en) 2008-10-01 2010-04-08 Cardiaq Valve Technologies, Inc. Delivery system for vascular implant
US20120290065A1 (en) 2011-05-12 2012-11-15 Boston Scientific Scimed Inc. Pre-Positioned Anastomosis Device and Related Methods of Use
US8795241B2 (en) 2011-05-13 2014-08-05 Spiration, Inc. Deployment catheter
CN106333749B (en) 2011-05-13 2020-01-03 斯波瑞申有限公司 Deployment catheter
CA2942484C (en) 2014-03-13 2022-09-27 Relevo, Inc. Persistent sanitizer composition

Patent Citations (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2981254A (en) * 1957-11-12 1961-04-25 Edwin G Vanderbilt Apparatus for the gas deflation of an animal's stomach
US3540431A (en) * 1968-04-04 1970-11-17 Kazi Mobin Uddin Collapsible filter for fluid flowing in closed passageway
US3760808A (en) * 1969-12-01 1973-09-25 K Bleuer Tampon applicator assembly
US3657744A (en) * 1970-05-08 1972-04-25 Univ Minnesota Method for fixing prosthetic implants in a living body
US3788327A (en) * 1971-03-30 1974-01-29 H Donowitz Surgical implant device
US3874388A (en) * 1973-02-12 1975-04-01 Ochsner Med Found Alton Shunt defect closure system
US4014318A (en) * 1973-08-20 1977-03-29 Dockum James M Circulatory assist device and system
US4086665A (en) * 1976-12-16 1978-05-02 Thermo Electron Corporation Artificial blood conduit
US4250873A (en) * 1977-04-26 1981-02-17 Richard Wolf Gmbh Endoscopes
US4212463A (en) * 1978-02-17 1980-07-15 Pratt Enoch B Humane bleeder arrow
US4850999A (en) * 1980-05-24 1989-07-25 Institute Fur Textil-Und Faserforschung Of Stuttgart Flexible hollow organ
US4808183A (en) * 1980-06-03 1989-02-28 University Of Iowa Research Foundation Voice button prosthesis and method for installing same
US4302854A (en) * 1980-06-04 1981-12-01 Runge Thomas M Electrically activated ferromagnetic/diamagnetic vascular shunt for left ventricular assist
US4727873A (en) * 1984-04-17 1988-03-01 Mobin Uddin Kazi Embolus trap
US4619246A (en) * 1984-05-23 1986-10-28 William Cook, Europe A/S Collapsible filter basket
US4819664A (en) * 1984-11-15 1989-04-11 Stefano Nazari Device for selective bronchial intubation and separate lung ventilation, particularly during anesthesia, intensive therapy and reanimation
US4732152A (en) * 1984-12-05 1988-03-22 Medinvent S.A. Device for implantation and a method of implantation in a vessel using such device
US4759758A (en) * 1984-12-07 1988-07-26 Shlomo Gabbay Prosthetic heart valve
US4681110A (en) * 1985-12-02 1987-07-21 Wiktor Dominik M Catheter arrangement having a blood vessel liner, and method of using it
US4710192A (en) * 1985-12-30 1987-12-01 Liotta Domingo S Diaphragm and method for occlusion of the descending thoracic aorta
US4832680A (en) * 1986-07-03 1989-05-23 C.R. Bard, Inc. Apparatus for hypodermically implanting a genitourinary prosthesis
US4795449A (en) * 1986-08-04 1989-01-03 Hollister Incorporated Female urinary incontinence device
US4852568A (en) * 1987-02-17 1989-08-01 Kensey Nash Corporation Method and apparatus for sealing an opening in tissue of a living being
US4934999A (en) * 1987-07-28 1990-06-19 Paul Bader Closure for a male urethra
US4830003A (en) * 1988-06-17 1989-05-16 Wolff Rodney G Compressive stent and delivery system
US4846836A (en) * 1988-10-03 1989-07-11 Reich Jonathan D Artificial lower gastrointestinal valve
US4877025A (en) * 1988-10-06 1989-10-31 Hanson Donald W Tracheostomy tube valve apparatus
US5116564A (en) * 1988-10-11 1992-05-26 Josef Jansen Method of producing a closing member having flexible closing elements, especially a heart valve
US4968294A (en) * 1989-02-09 1990-11-06 Salama Fouad A Urinary control valve and method of using same
US5352240A (en) * 1989-05-31 1994-10-04 Promedica International, Inc. Human heart valve replacement with porcine pulmonary valve
US5314473A (en) * 1989-07-20 1994-05-24 Godin Norman J Prosthesis for preventing gastric reflux into the esophagus
US5061274A (en) * 1989-12-04 1991-10-29 Kensey Nash Corporation Plug device for sealing openings and method of use
US5158548A (en) * 1990-04-25 1992-10-27 Advanced Cardiovascular Systems, Inc. Method and system for stent delivery
US5116360A (en) * 1990-12-27 1992-05-26 Corvita Corporation Mesh composite graft
US5358518A (en) * 1991-06-25 1994-10-25 Sante Camilli Artificial venous valve
US5161524A (en) * 1991-08-02 1992-11-10 Glaxo Inc. Dosage inhalator with air flow velocity regulating means
US5151105A (en) * 1991-10-07 1992-09-29 Kwan Gett Clifford Collapsible vessel sleeve implant
US5123919A (en) * 1991-11-21 1992-06-23 Carbomedics, Inc. Combined prosthetic aortic heart valve and vascular graft
US5283063A (en) * 1992-01-31 1994-02-01 Eagle Vision Punctum plug method and apparatus
US5509900A (en) * 1992-03-02 1996-04-23 Kirkman; Thomas R. Apparatus and method for retaining a catheter in a blood vessel in a fixed position
US5382261A (en) * 1992-09-01 1995-01-17 Expandable Grafts Partnership Method and apparatus for occluding vessels
US5409019A (en) * 1992-10-30 1995-04-25 Wilk; Peter J. Coronary artery by-pass method
US5304199A (en) * 1993-01-04 1994-04-19 Gene E. Myers Enterprises, Inc. Apparatus for arterial total occlusion plaque separation
US5797960A (en) * 1993-02-22 1998-08-25 Stevens; John H. Method and apparatus for thoracoscopic intracardiac procedures
US5306234A (en) * 1993-03-23 1994-04-26 Johnson W Dudley Method for closing an atrial appendage
US5603698A (en) * 1993-04-13 1997-02-18 Boston Scientific Corporation Prosthesis delivery system
US5366478A (en) * 1993-07-27 1994-11-22 Ethicon, Inc. Endoscopic surgical sealing device
US5453090A (en) * 1994-03-01 1995-09-26 Cordis Corporation Method of stent delivery through an elongate softenable sheath
US5392775A (en) * 1994-03-22 1995-02-28 Adkins, Jr.; Claude N. Duckbill valve for a tracheostomy tube that permits speech
US5803078A (en) * 1994-05-06 1998-09-08 Brauner; Mark E. Methods and apparatus for intrapulmonary therapy and drug administration
US5549626A (en) * 1994-12-23 1996-08-27 New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery Vena caval filter
US5755770A (en) * 1995-01-31 1998-05-26 Boston Scientific Corporatiion Endovascular aortic graft
US5855601A (en) * 1996-06-21 1999-01-05 The Trustees Of Columbia University In The City Of New York Artificial heart valve and method and device for implanting the same
US6447530B1 (en) * 1996-11-27 2002-09-10 Scimed Life Systems, Inc. Atraumatic anchoring and disengagement mechanism for permanent implant device
US6287334B1 (en) * 1996-12-18 2001-09-11 Venpro Corporation Device for regulating the flow of blood through the blood system
US5851232A (en) * 1997-03-15 1998-12-22 Lois; William A. Venous stent
US6267775B1 (en) * 1997-03-21 2001-07-31 Schneider (Usa) Inc. Self-expanding medical device for centering radioactive treatment sources in body vessels
US6488673B1 (en) * 1997-04-07 2002-12-03 Broncus Technologies, Inc. Method of increasing gas exchange of a lung
US5954636A (en) * 1997-07-15 1999-09-21 Schwartz; Roy E. Pediatric endotracheal tube with bronchial blocker and method for selectively blocking respiratory airflow to a pediatric patient's lung
US5954766A (en) * 1997-09-16 1999-09-21 Zadno-Azizi; Gholam-Reza Body fluid flow control device
US5925063A (en) * 1997-09-26 1999-07-20 Khosravi; Farhad Coiled sheet valve, filter or occlusive device and methods of use
US6238334B1 (en) * 1997-11-03 2001-05-29 Cardio Technologies, Inc. Method and apparatus for assisting a heart to pump blood
US6558429B2 (en) * 1997-12-09 2003-05-06 Reflux Corporation Perorally insertable gastroesophageal anti-reflux valve prosthesis and tool for implantation thereof
US6174323B1 (en) * 1998-06-05 2001-01-16 Broncus Technologies, Inc. Method and assembly for lung volume reduction
US6149664A (en) * 1998-08-27 2000-11-21 Micrus Corporation Shape memory pusher introducer for vasoocclusive devices
US20030180922A1 (en) * 1998-12-30 2003-09-25 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US6439233B1 (en) * 1999-02-01 2002-08-27 ADEVA Medical Gesellschaft für Entwicklung und Vertrieb von Medizinischen Implantat-Artikeln mbH Tracheal stoma valve
US20010056274A1 (en) * 1999-07-02 2001-12-27 Perkins Rodney A. Methods, systems, and kits for lung volume reduction
US20020062120A1 (en) * 1999-07-02 2002-05-23 Pulmonx Methods, systems, and kits for lung volume reduction
US6287290B1 (en) * 1999-07-02 2001-09-11 Pulmonx Methods, systems, and kits for lung volume reduction
US6629951B2 (en) * 1999-08-05 2003-10-07 Broncus Technologies, Inc. Devices for creating collateral in the lungs
US20010051799A1 (en) * 1999-08-23 2001-12-13 Ingenito Edward P. Tissue volume reduction
US6293951B1 (en) * 1999-08-24 2001-09-25 Spiration, Inc. Lung reduction device, system, and method
US6258100B1 (en) * 1999-08-24 2001-07-10 Spiration, Inc. Method of reducing lung size
US6398775B1 (en) * 1999-10-21 2002-06-04 Pulmonx Apparatus and method for isolated lung access
US20020077593A1 (en) * 1999-10-21 2002-06-20 Pulmonx Apparatus and method for isolated lung access
US6694979B2 (en) * 2000-03-04 2004-02-24 Emphasys Medical, Inc. Methods and devices for use in performing pulmonary procedures
US20010037808A1 (en) * 2000-03-04 2001-11-08 Deem Mark E. Methods and devices for use in performing pulmonary procedures
US6679264B1 (en) * 2000-03-04 2004-01-20 Emphasys Medical, Inc. Methods and devices for use in performing pulmonary procedures
US6328689B1 (en) * 2000-03-23 2001-12-11 Spiration, Inc., Lung constriction apparatus and method
US20020147462A1 (en) * 2000-09-11 2002-10-10 Closure Medical Corporation Bronchial occlusion method and apparatus
US6527761B1 (en) * 2000-10-27 2003-03-04 Pulmonx, Inc. Methods and devices for obstructing and aspirating lung tissue segments
US6585639B1 (en) * 2000-10-27 2003-07-01 Pulmonx Sheath and method for reconfiguring lung viewing scope
US20020112729A1 (en) * 2001-02-21 2002-08-22 Spiration, Inc. Intra-bronchial obstructing device that controls biological interaction with the patient
US20030013935A1 (en) * 2001-07-10 2003-01-16 Spiration, Inc. Constriction device viewable under X ray fluoroscopy
US20030024527A1 (en) * 2001-08-03 2003-02-06 Integrated Vascular Systems, Inc. Lung assist apparatus and methods for use
US20040243140A1 (en) * 2001-09-11 2004-12-02 Alferness Clifton A. Collapsible intra-bronchial valve devices
US20030050648A1 (en) * 2001-09-11 2003-03-13 Spiration, Inc. Removable lung reduction devices, systems, and methods
US20030070682A1 (en) * 2001-10-11 2003-04-17 Wilson Peter M. Bronchial flow control devices and methods of use
US20030183235A1 (en) * 2001-10-25 2003-10-02 Spiration, Inc. Bronchial obstruction device deployment system and method
US6592594B2 (en) * 2001-10-25 2003-07-15 Spiration, Inc. Bronchial obstruction device deployment system and method
US20030083671A1 (en) * 2001-10-25 2003-05-01 Spiration, Inc. Bronchial obstruction device deployment system and method
US20030158515A1 (en) * 2002-02-21 2003-08-21 Spiration, Inc. Device and method for intra-bronchial provision of a therapeutic agent
US20030154988A1 (en) * 2002-02-21 2003-08-21 Spiration, Inc. Intra-bronchial device that provides a medicant intra-bronchially to the patient
US20030167065A1 (en) * 2002-03-01 2003-09-04 Arvik Enterprises, Llc Blood vessel occlusion device
US20030195385A1 (en) * 2002-04-16 2003-10-16 Spiration, Inc. Removable anchored lung volume reduction devices and methods
US20030212412A1 (en) * 2002-05-09 2003-11-13 Spiration, Inc. Intra-bronchial obstructing device that permits mucus transport
US20040039250A1 (en) * 2002-05-28 2004-02-26 David Tholfsen Guidewire delivery of implantable bronchial isolation devices in accordance with lung treatment

Cited By (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7757692B2 (en) 2001-09-11 2010-07-20 Spiration, Inc. Removable lung reduction devices, systems, and methods
US8414655B2 (en) 2001-09-11 2013-04-09 Spiration, Inc. Removable lung reduction devices, systems, and methods
US8974484B2 (en) 2001-09-11 2015-03-10 Spiration, Inc. Removable lung reduction devices, systems, and methods
US20030050648A1 (en) * 2001-09-11 2003-03-13 Spiration, Inc. Removable lung reduction devices, systems, and methods
US7942931B2 (en) 2002-02-21 2011-05-17 Spiration, Inc. Device and method for intra-bronchial provision of a therapeutic agent
US8926647B2 (en) 2002-03-20 2015-01-06 Spiration, Inc. Removable anchored lung volume reduction devices and methods
US20150305749A1 (en) * 2002-03-20 2015-10-29 Spiration, Inc. Removable anchored lung volume reduction devices and methods
US8177805B2 (en) 2002-03-20 2012-05-15 Spiration, Inc. Removable anchored lung volume reduction devices and methods
US8021385B2 (en) 2002-03-20 2011-09-20 Spiration, Inc. Removable anchored lung volume reduction devices and methods
US20030212412A1 (en) * 2002-05-09 2003-11-13 Spiration, Inc. Intra-bronchial obstructing device that permits mucus transport
US7875048B2 (en) 2002-05-17 2011-01-25 Spiration, Inc. One-way valve devices for anchored implantation in a lung
US8956319B2 (en) 2002-05-17 2015-02-17 Spiration, Inc. One-way valve devices for anchored implantation in a lung
US8257381B2 (en) 2002-05-17 2012-09-04 Spiration, Inc. One-way valve devices for anchored implantation in a lung
US7842061B2 (en) 2002-05-17 2010-11-30 Spiration, Inc. Methods of achieving lung volume reduction with removable anchored devices
WO2004080347A2 (en) 2003-03-12 2004-09-23 Spiration Inc. Apparatus, method and assembly for delivery of intra-bronchial devices
US20040210248A1 (en) * 2003-03-12 2004-10-21 Spiration, Inc. Apparatus, method and assembly for delivery of intra-bronchial devices
US8079368B2 (en) 2003-04-08 2011-12-20 Spiration, Inc. Bronchoscopic lung volume reduction method
US7828789B2 (en) 2003-05-07 2010-11-09 Portaero, Inc. Device and method for creating a localized pleurodesis and treating a lung through the localized pleurodesis
US8029492B2 (en) 2003-05-07 2011-10-04 Portaero, Inc. Method for treating chronic obstructive pulmonary disease
US7811274B2 (en) 2003-05-07 2010-10-12 Portaero, Inc. Method for treating chronic obstructive pulmonary disease
US7789083B2 (en) 2003-05-20 2010-09-07 Portaero, Inc. Intra/extra thoracic system for ameliorating a symptom of chronic obstructive pulmonary disease
US7896008B2 (en) 2003-06-03 2011-03-01 Portaero, Inc. Lung reduction system
US7753052B2 (en) 2003-06-05 2010-07-13 Portaero, Inc. Intra-thoracic collateral ventilation bypass system
US7682332B2 (en) 2003-07-15 2010-03-23 Portaero, Inc. Methods to accelerate wound healing in thoracic anastomosis applications
US8323230B2 (en) 2003-07-15 2012-12-04 Portaero, Inc. Methods and devices to accelerate wound healing in thoracic anastomosis applications
US9622752B2 (en) 2003-08-08 2017-04-18 Spiration, Inc. Bronchoscopic repair of air leaks in a lung
US8974527B2 (en) 2003-08-08 2015-03-10 Spiration, Inc. Bronchoscopic repair of air leaks in a lung
US7451765B2 (en) 2004-11-18 2008-11-18 Mark Adler Intra-bronchial apparatus for aspiration and insufflation of lung regions distal to placement or cross communication and deployment and placement system therefor
US8220460B2 (en) 2004-11-19 2012-07-17 Portaero, Inc. Evacuation device and method for creating a localized pleurodesis
US7824366B2 (en) 2004-12-10 2010-11-02 Portaero, Inc. Collateral ventilation device with chest tube/evacuation features and method
US8104474B2 (en) 2005-08-23 2012-01-31 Portaero, Inc. Collateral ventilation bypass system with retention features
US7726305B2 (en) 2006-01-17 2010-06-01 Portaero, Inc. Variable resistance pulmonary ventilation bypass valve
US7686013B2 (en) 2006-01-17 2010-03-30 Portaero, Inc. Variable resistance pulmonary ventilation bypass valve
US7691151B2 (en) 2006-03-31 2010-04-06 Spiration, Inc. Articulable Anchor
US8647392B2 (en) 2006-03-31 2014-02-11 Spiration, Inc. Articulable anchor
US9198669B2 (en) 2006-03-31 2015-12-01 Spiration, Inc. Articulable anchor
US20070232992A1 (en) * 2006-03-31 2007-10-04 James Kutsko Articulable anchor
US8454708B2 (en) 2006-03-31 2013-06-04 Spiration, Inc. Articulable anchor
US8163034B2 (en) 2007-05-11 2012-04-24 Portaero, Inc. Methods and devices to create a chemically and/or mechanically localized pleurodesis
US7931641B2 (en) 2007-05-11 2011-04-26 Portaero, Inc. Visceral pleura ring connector
US8062315B2 (en) 2007-05-17 2011-11-22 Portaero, Inc. Variable parietal/visceral pleural coupling
US8043301B2 (en) 2007-10-12 2011-10-25 Spiration, Inc. Valve loader method, system, and apparatus
US8136230B2 (en) 2007-10-12 2012-03-20 Spiration, Inc. Valve loader method, system, and apparatus
US20120016376A1 (en) * 2007-10-12 2012-01-19 Spiration, Inc. Valve loader method, system, and apparatus
US9326873B2 (en) 2007-10-12 2016-05-03 Spiration, Inc. Valve loader method, system, and apparatus
US8231581B2 (en) 2008-02-19 2012-07-31 Portaero, Inc. Enhanced pneumostoma management device and methods for treatment of chronic obstructive pulmonary disease
US8336540B2 (en) 2008-02-19 2012-12-25 Portaero, Inc. Pneumostoma management device and method for treatment of chronic obstructive pulmonary disease
US8430094B2 (en) 2008-02-19 2013-04-30 Portaero, Inc. Flexible pneumostoma management system and methods for treatment of chronic obstructive pulmonary disease
US8453637B2 (en) 2008-02-19 2013-06-04 Portaero, Inc. Pneumostoma management system for treatment of chronic obstructive pulmonary disease
US8464708B2 (en) 2008-02-19 2013-06-18 Portaero, Inc. Pneumostoma management system having a cosmetic and/or protective cover
US8474449B2 (en) 2008-02-19 2013-07-02 Portaero, Inc. Variable length pneumostoma management system for treatment of chronic obstructive pulmonary disease
US8475389B2 (en) 2008-02-19 2013-07-02 Portaero, Inc. Methods and devices for assessment of pneumostoma function
US8491602B2 (en) 2008-02-19 2013-07-23 Portaero, Inc. Single-phase surgical procedure for creating a pneumostoma to treat chronic obstructive pulmonary disease
US8506577B2 (en) 2008-02-19 2013-08-13 Portaero, Inc. Two-phase surgical procedure for creating a pneumostoma to treat chronic obstructive pulmonary disease
US7909803B2 (en) 2008-02-19 2011-03-22 Portaero, Inc. Enhanced pneumostoma management device and methods for treatment of chronic obstructive pulmonary disease
US8365722B2 (en) 2008-02-19 2013-02-05 Portaero, Inc. Multi-layer pneumostoma management system and methods for treatment of chronic obstructive pulmonary disease
US7927324B2 (en) 2008-02-19 2011-04-19 Portaero, Inc. Aspirator and method for pneumostoma management
US8347880B2 (en) 2008-02-19 2013-01-08 Potaero, Inc. Pneumostoma management system with secretion management features for treatment of chronic obstructive pulmonary disease
US8348906B2 (en) 2008-02-19 2013-01-08 Portaero, Inc. Aspirator for pneumostoma management
US8021320B2 (en) 2008-02-19 2011-09-20 Portaero, Inc. Self-sealing device and method for delivery of a therapeutic agent through a pneumostoma
US8453638B2 (en) 2008-02-19 2013-06-04 Portaero, Inc. One-piece pneumostoma management system and methods for treatment of chronic obstructive pulmonary disease
US8252003B2 (en) 2008-02-19 2012-08-28 Portaero, Inc. Surgical instruments for creating a pneumostoma and treating chronic obstructive pulmonary disease
US8347881B2 (en) 2009-01-08 2013-01-08 Portaero, Inc. Pneumostoma management device with integrated patency sensor and method
US8518053B2 (en) 2009-02-11 2013-08-27 Portaero, Inc. Surgical instruments for creating a pneumostoma and treating chronic obstructive pulmonary disease
JP2017213388A (en) * 2009-05-18 2017-12-07 ヌームアールエックス・インコーポレーテッド Cross-sectional modification method during deployment of elongate lung volume reduction device
US8795241B2 (en) 2011-05-13 2014-08-05 Spiration, Inc. Deployment catheter
WO2015153500A1 (en) * 2014-03-31 2015-10-08 Spiration, Inc. Simulated valve device for airway
US20170181665A1 (en) * 2014-03-31 2017-06-29 Spiration, Inc. D.B.A. Olympus Respiratory America Light-based endoluminal sizing device
US11602286B2 (en) * 2014-03-31 2023-03-14 Gyrus Acmi, Inc. Simulated valve device for airway
CN111513662A (en) * 2014-03-31 2020-08-11 捷锐士股份有限公司 Anchoring mechanisms and systems for endoluminal devices
US10624733B2 (en) 2015-03-24 2020-04-21 Spiration, Inc. Airway stent
US11039926B2 (en) 2016-03-25 2021-06-22 Spiration, Inc. Valve planning tool
US11826255B2 (en) 2016-03-25 2023-11-28 Gyrus Acmi, Inc. Valve planning tool
CN110742667A (en) * 2018-07-23 2020-02-04 苏州优友瑞医疗科技有限公司 Methods and devices for treating pulmonary dysfunction using implantable valves
CN116531142A (en) * 2023-06-13 2023-08-04 金傅(北京)医疗科技有限公司 Double-layer tectorial membrane structure of bronchus valve

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US8257381B2 (en) 2012-09-04
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US20040167636A1 (en) 2004-08-26
US7842061B2 (en) 2010-11-30
US7434578B2 (en) 2008-10-14
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US7875048B2 (en) 2011-01-25
US9358013B2 (en) 2016-06-07

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