US1197971A - Nuclein-arsenic compounds and process of preparing same. - Google Patents

Nuclein-arsenic compounds and process of preparing same. Download PDF

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Publication number
US1197971A
US1197971A US84289714A US1914842897A US1197971A US 1197971 A US1197971 A US 1197971A US 84289714 A US84289714 A US 84289714A US 1914842897 A US1914842897 A US 1914842897A US 1197971 A US1197971 A US 1197971A
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Prior art keywords
nuclein
compound
arsenic
preparing same
arsenic compounds
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US84289714A
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Ludwig A Thiele
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Definitions

  • My invention relates to a new and useful composition of matter, provide a chemical compound'ha'vlng vari ous new and useful qualities andparticularly adapted as a specific remedy for the I for instance, by with arsenic salts ture evaporated until dry with constantis a pale yellow powder stirring. The result Which is then dissolved in boiling water to form a saturated solution from which upon cooling, a nuclein-arsenic compound will be precipitated in the form of crystalline needles.
  • This new product is soluble in water, alkalis, and inalkali metal carbonates. When heated; this compound assumes a dark color at 180 0., :and decomposes on further heating. this new compound are altered on exposure to air and by light. arsenic compound is found to be Specification of Letters Patent. Application filed June 4,
  • the therapeutic ef ficiency-fof. the above nuclein-arsenic compounds consists in the quality of acting upomBacrc/wZerw euis.
  • he said new compound may be practically administered of the same of 8% to 15% strength in the subcutaneous connective tissue. Administration per os is excluded. According to present experience, it is best to administer doses of one-tenth grain per pound of body weight,- which may be eventually repeated from time to time, as indicated by the symptoms.

Description

1 vented certain LUDWIG A. THIELE, or urrnn SANDUSKY, o'HIo.
NUCLEIN-ARSENIO COMPOUNDS AND PROCESs or PREPARING sail/ n f No Drawing.
T all whom it may concern Be it known that I, LUDYVIG' A; THIriLE,
a c tizen ofthe-United Statesof America,"
residing at Upper Sandusky, in the county of Wyandot and State of Ohio, have innew and useful Improve:
merits in N uclein-Arsenic Compounds and Processes of Preparing Same; and I do fjhereby declare the following to be a full, clear, and exact description of the inven- 'tion, such as will enable others skilled in the art to which it the same.
appertains to make and use My invention relates to a new and useful composition of matter, provide a chemical compound'ha'vlng vari ous new and useful qualities andparticularly adapted as a specific remedy for the I for instance, by with arsenic salts ture evaporated until dry with constantis a pale yellow powder stirring. The result Which is then dissolved in boiling water to form a saturated solution from which upon cooling, a nuclein-arsenic compound will be precipitated in the form of crystalline needles. This new product is soluble in water, alkalis, and inalkali metal carbonates. When heated; this compound assumes a dark color at 180 0., :and decomposes on further heating. this new compound are altered on exposure to air and by light. arsenic compound is found to be Specification of Letters Patent. Application filed June 4,
, febris j recurrens,-' and and its object is to I have discovered that,
com-' presence of phenol, its salts or .deri at I Inc compounds which wit Take 1.28 kilo The alkaline solutions of f Thisxnew nuclein- I a' specific I for the cure of cholera suis, (liog chclera) 1914. Serial No. 842,897.
mals, and.a1so veryeffective for immunizing various animals exposedgto such diseases. The therapeutic ef ficiency-fof. the above nuclein-arsenic compounds, consists in the quality of acting upomBacrc/wZerw euis.
and its associates,
and neutralizing toxins produced 1 by the aforesaid bacilli.
like diseases of anirammed Sept. '12, acre.
he said new compound may be practically administered of the same of 8% to 15% strength in the subcutaneous connective tissue. Administration per os is excluded. According to present experience, it is best to administer doses of one-tenth grain per pound of body weight,- which may be eventually repeated from time to time, as indicated by the symptoms.
What I claim is he process tween a nuclelnlc-acid and an arsenic salt in phenylic compound.
T e process of preparing nuclein-arsecomprises treating a mixture ofa phenylic compound and a compound comprising a nucleinic acid radical, with a soluble compound of arsenic.
3. The process of preparing nucl ein-arse-' a nucleinicjacid in anaqueous solution of an alkali phenate,' admixing therewith a soluble cacodylate and treating the mixture under suitable reacting conditions to obtain the desirfil nuclein-arseni'c compound.
ing arsenic in comblnatlon with a nucleinic acid, said compound'being soluble in water and alkaline solutions, darkening when heated toabout. 180 C above that temperature, and possessing valuable therapeutic properties.
In testimony whereof I aflix my signature presence of two witnesses.
, LUDWIGA. THIELET Witnes'ses:'
W. M. SMAL LI BY, G. D. HA
I nuclein-arsenic compound comprisby injectinga solution and decomposing
US84289714A 1914-06-04 1914-06-04 Nuclein-arsenic compounds and process of preparing same. Expired - Lifetime US1197971A (en)

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US84289714A US1197971A (en) 1914-06-04 1914-06-04 Nuclein-arsenic compounds and process of preparing same.

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010000041A1 (en) * 1997-12-19 2001-03-15 Selmon Matthew R. Methods and apparatus for crossing vascular occlusions
US20020103459A1 (en) * 2000-12-05 2002-08-01 Sparks Kurt D. Catheter system for vascular re-entry from a sub-intimal space

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010000041A1 (en) * 1997-12-19 2001-03-15 Selmon Matthew R. Methods and apparatus for crossing vascular occlusions
US20020103459A1 (en) * 2000-12-05 2002-08-01 Sparks Kurt D. Catheter system for vascular re-entry from a sub-intimal space

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