DE69938013D1 - Vorrichtung zur Elektroporation ohne Gewebepenetration - Google Patents

Vorrichtung zur Elektroporation ohne Gewebepenetration

Info

Publication number
DE69938013D1
DE69938013D1 DE69938013T DE69938013T DE69938013D1 DE 69938013 D1 DE69938013 D1 DE 69938013D1 DE 69938013 T DE69938013 T DE 69938013T DE 69938013 T DE69938013 T DE 69938013T DE 69938013 D1 DE69938013 D1 DE 69938013D1
Authority
DE
Germany
Prior art keywords
target tissue
electrodes
establish
electromagnetic field
support
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69938013T
Other languages
English (en)
Other versions
DE69938013T2 (de
Inventor
Richard Gilbert
Mark J Jaroszeski
Richard Heller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of South Florida
Original Assignee
University of South Florida
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of South Florida filed Critical University of South Florida
Publication of DE69938013D1 publication Critical patent/DE69938013D1/de
Application granted granted Critical
Publication of DE69938013T2 publication Critical patent/DE69938013T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/0404Electrodes for external use
    • A61N1/0408Use-related aspects
    • A61N1/0412Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A61N1/0416Anode and cathode
    • A61N1/0424Shape of the electrode
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/0404Electrodes for external use
    • A61N1/0472Structure-related aspects
    • A61N1/0476Array electrodes (including any electrode arrangement with more than one electrode for at least one of the polarities)
DE69938013T 1998-12-17 1999-12-15 Vorrichtung zur Elektroporation ohne Gewebepenetration Expired - Lifetime DE69938013T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/213,218 US6314316B1 (en) 1998-12-17 1998-12-17 Nonpenetrating electroporation device and method
US213218 1998-12-17

Publications (2)

Publication Number Publication Date
DE69938013D1 true DE69938013D1 (de) 2008-03-06
DE69938013T2 DE69938013T2 (de) 2009-01-15

Family

ID=22794209

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69923787T Expired - Lifetime DE69923787T2 (de) 1998-12-17 1999-12-15 Vorrichtung zur elektroporation ohne gewebepenetration
DE69938013T Expired - Lifetime DE69938013T2 (de) 1998-12-17 1999-12-15 Vorrichtung zur Elektroporation ohne Gewebepenetration

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69923787T Expired - Lifetime DE69923787T2 (de) 1998-12-17 1999-12-15 Vorrichtung zur elektroporation ohne gewebepenetration

Country Status (8)

Country Link
US (1) US6314316B1 (de)
EP (2) EP1140282B1 (de)
JP (1) JP2002532166A (de)
AT (1) ATE289215T1 (de)
AU (1) AU768451B2 (de)
CA (1) CA2355051C (de)
DE (2) DE69923787T2 (de)
WO (1) WO2000035532A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6714816B1 (en) * 2000-02-22 2004-03-30 University Of South Florida Electroporation and electrophoresis system and method for achieving molecular penetration into cells in vivo
AU2002245675A1 (en) * 2001-03-13 2002-09-24 University Of South Florida Electromanipulation device and method
US8209006B2 (en) * 2002-03-07 2012-06-26 Vgx Pharmaceuticals, Inc. Constant current electroporation device and methods of use
US7245963B2 (en) * 2002-03-07 2007-07-17 Advisys, Inc. Electrode assembly for constant-current electroporation and use
WO2006080934A2 (en) * 2004-04-19 2006-08-03 Invitrogen Corporation Electroporation apparatus and methods
ES2367921T3 (es) * 2005-04-18 2011-11-10 INSERM (Institut National de la Santé et de la Recherche Médicale) Procedimiento y dispositivos para el suministro de un producto terapéutico a la esfera ocular de un paciente.
WO2007117651A2 (en) 2006-04-07 2007-10-18 University Of South Florida Passive electric field focus system for in vivo and in vitro applications
DE102006022554B4 (de) * 2006-05-15 2014-12-04 Roche Diagnostics Gmbh Verfahren und Vorrichtung zum Stimulieren eines Gewebes für die subkutane Verabreichung von Wirkstoffen
EP4328297A2 (de) * 2008-01-17 2024-02-28 Inovio Pharmaceuticals, Inc. Einzelnadelelektroporationssystem und -verfahren mit variabler stromdichte
WO2010106544A1 (en) * 2009-03-16 2010-09-23 Rajah Vijay Kumar A method and apparatus for - focused resonance nanopermeabilization (forn)
WO2016017045A1 (ja) * 2014-07-28 2016-02-04 ネッパジーン株式会社 エレクトロポレーター用電気パルス発生器及び前記電気パルス発生器を備えたエレクトロポレーター装置
JP5822247B1 (ja) * 2014-07-28 2015-11-24 ネッパジーン株式会社 エレクトロポレーター用電気パルス発生器及び前記電気パルス発生器を備えたエレクトロポレーター装置

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1099062A (en) * 1913-12-10 1914-06-02 Peter P Laposkey Electric scalp appliance.
US4970154A (en) * 1987-10-09 1990-11-13 Baylor College Of Medicine Method for inserting foreign genes into cells using pulsed radiofrequency
US5318514A (en) 1992-08-17 1994-06-07 Btx, Inc. Applicator for the electroporation of drugs and genes into surface cells
US6009345A (en) * 1992-08-17 1999-12-28 Genetronics, Inc. Method and apparatus for a combination of electroporation and iontophoresis for the delivery of drugs and genes
FR2703253B1 (fr) 1993-03-30 1995-06-23 Centre Nat Rech Scient Applicateur d'impulsions electriques pour traitement de tissus biologiques.
US5993434A (en) 1993-04-01 1999-11-30 Genetronics, Inc. Method of treatment using electroporation mediated delivery of drugs and genes
US5439440A (en) 1993-04-01 1995-08-08 Genetronics, Inc. Electroporation system with voltage control feedback for clinical applications
US5707349A (en) * 1994-05-09 1998-01-13 Somnus Medical Technologies, Inc. Method for treatment of air way obstructions
US5983130A (en) * 1995-06-07 1999-11-09 Alza Corporation Electrotransport agent delivery method and apparatus
JPH09266954A (ja) * 1996-04-03 1997-10-14 Meiwa Shoji Kk 電極付治療器具
US5869326A (en) * 1996-09-09 1999-02-09 Genetronics, Inc. Electroporation employing user-configured pulsing scheme
US5873849A (en) * 1997-04-24 1999-02-23 Ichor Medical Systems, Inc. Electrodes and electrode arrays for generating electroporation inducing electrical fields

Also Published As

Publication number Publication date
JP2002532166A (ja) 2002-10-02
AU768451B2 (en) 2003-12-11
EP1504787A1 (de) 2005-02-09
EP1140282A1 (de) 2001-10-10
WO2000035532A1 (en) 2000-06-22
EP1140282B1 (de) 2005-02-16
CA2355051C (en) 2003-12-09
DE69923787D1 (de) 2005-03-24
AU2053600A (en) 2000-07-03
DE69938013T2 (de) 2009-01-15
DE69923787T2 (de) 2006-01-05
US6314316B1 (en) 2001-11-06
CA2355051A1 (en) 2000-06-22
ATE289215T1 (de) 2005-03-15
EP1504787B1 (de) 2008-01-16

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