DE60318446D1 - Nichtpolymere lipophile pharmazeutische implantat-zusammensetzungen für die intraokulare anwendung - Google Patents

Nichtpolymere lipophile pharmazeutische implantat-zusammensetzungen für die intraokulare anwendung

Info

Publication number
DE60318446D1
DE60318446D1 DE60318446T DE60318446T DE60318446D1 DE 60318446 D1 DE60318446 D1 DE 60318446D1 DE 60318446 T DE60318446 T DE 60318446T DE 60318446 T DE60318446 T DE 60318446T DE 60318446 D1 DE60318446 D1 DE 60318446D1
Authority
DE
Germany
Prior art keywords
oxular
intra
application
implant compositions
lipophilic pharmaceutical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60318446T
Other languages
English (en)
Other versions
DE60318446T2 (de
Inventor
Bhagwati P Kabra
Janet D Howie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Inc
Original Assignee
Alcon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Inc filed Critical Alcon Inc
Application granted granted Critical
Publication of DE60318446D1 publication Critical patent/DE60318446D1/de
Publication of DE60318446T2 publication Critical patent/DE60318446T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • A61K9/0051Ocular inserts, ocular implants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38Cellulose; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1617Organic compounds, e.g. phospholipids, fats
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007Drug-containing films, membranes or sheets
DE60318446T 2002-07-15 2003-06-30 Nichtpolymere lipophile pharmazeutische implantat-zusammensetzungen für die intraokulare anwendung Expired - Lifetime DE60318446T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39584002P 2002-07-15 2002-07-15
US395840P 2002-07-15
PCT/US2003/020707 WO2004006890A1 (en) 2002-07-15 2003-06-30 Non-polymeric lipophilic pharmaceutical implant compositions for intraocular use

Publications (2)

Publication Number Publication Date
DE60318446D1 true DE60318446D1 (de) 2008-02-14
DE60318446T2 DE60318446T2 (de) 2008-05-21

Family

ID=30115932

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60318446T Expired - Lifetime DE60318446T2 (de) 2002-07-15 2003-06-30 Nichtpolymere lipophile pharmazeutische implantat-zusammensetzungen für die intraokulare anwendung

Country Status (18)

Country Link
US (2) US7678827B2 (de)
EP (1) EP1521573B1 (de)
JP (1) JP4463681B2 (de)
KR (1) KR101003518B1 (de)
CN (1) CN100355455C (de)
AT (1) ATE382330T1 (de)
AU (1) AU2003248777B2 (de)
BR (1) BR0312635A (de)
CA (1) CA2491313C (de)
CY (1) CY1107166T1 (de)
DE (1) DE60318446T2 (de)
DK (1) DK1521573T3 (de)
ES (1) ES2295647T3 (de)
MX (1) MXPA05000632A (de)
PL (1) PL206594B1 (de)
PT (1) PT1521573E (de)
WO (1) WO2004006890A1 (de)
ZA (2) ZA200410096B (de)

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US20070184089A1 (en) * 2002-07-15 2007-08-09 Alcon, Inc. Non-Polymeric Lipophilic Pharmaceutical Implant Compositions for Intraocular Use
DK1521573T3 (da) * 2002-07-15 2008-03-25 Alcon Inc Ikke-polymere, lipofile, farmaceutiske implantatsammensætninger til intrakulær anvendelse
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US9867880B2 (en) 2012-06-13 2018-01-16 Atrium Medical Corporation Cured oil-hydrogel biomaterial compositions for controlled drug delivery
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CN105451731B (zh) * 2013-09-26 2019-01-18 参天制药株式会社 含有经稳定化的2-氨基-3-(4-溴苯甲酰基)苯乙酸的水性组合物
US20150342875A1 (en) 2014-05-29 2015-12-03 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
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Also Published As

Publication number Publication date
KR101003518B1 (ko) 2010-12-30
AU2003248777A1 (en) 2004-02-02
CN100355455C (zh) 2007-12-19
US20080241224A1 (en) 2008-10-02
ZA200410096B (en) 2006-07-26
KR20050023409A (ko) 2005-03-09
BR0312635A (pt) 2005-04-19
ATE382330T1 (de) 2008-01-15
US8178576B2 (en) 2012-05-15
DE60318446T2 (de) 2008-05-21
PL206594B1 (pl) 2010-08-31
PL374743A1 (en) 2005-10-31
PT1521573E (pt) 2008-02-08
CA2491313A1 (en) 2004-01-22
US20040013704A1 (en) 2004-01-22
CY1107166T1 (el) 2012-10-24
CN1668277A (zh) 2005-09-14
CA2491313C (en) 2011-05-24
US7678827B2 (en) 2010-03-16
MXPA05000632A (es) 2005-03-31
DK1521573T3 (da) 2008-03-25
EP1521573B1 (de) 2008-01-02
JP4463681B2 (ja) 2010-05-19
AU2003248777B2 (en) 2008-02-14
ES2295647T3 (es) 2008-04-16
ZA200410095B (en) 2006-07-26
JP2006500328A (ja) 2006-01-05
WO2004006890A1 (en) 2004-01-22
EP1521573A1 (de) 2005-04-13

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