DE60318446D1 - Nichtpolymere lipophile pharmazeutische implantat-zusammensetzungen für die intraokulare anwendung - Google Patents

Nichtpolymere lipophile pharmazeutische implantat-zusammensetzungen für die intraokulare anwendung

Info

Publication number
DE60318446D1
DE60318446D1 DE60318446T DE60318446T DE60318446D1 DE 60318446 D1 DE60318446 D1 DE 60318446D1 DE 60318446 T DE60318446 T DE 60318446T DE 60318446 T DE60318446 T DE 60318446T DE 60318446 D1 DE60318446 D1 DE 60318446D1
Authority
DE
Germany
Prior art keywords
oxular
intra
application
implant compositions
lipophilic pharmaceutical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60318446T
Other languages
English (en)
Other versions
DE60318446T2 (de
Inventor
Bhagwati P Kabra
Janet D Howie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Inc
Original Assignee
Alcon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Inc filed Critical Alcon Inc
Application granted granted Critical
Publication of DE60318446D1 publication Critical patent/DE60318446D1/de
Publication of DE60318446T2 publication Critical patent/DE60318446T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
DE60318446T 2002-07-15 2003-06-30 Nichtpolymere lipophile pharmazeutische implantat-zusammensetzungen für die intraokulare anwendung Expired - Lifetime DE60318446T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39584002P 2002-07-15 2002-07-15
US395840P 2002-07-15
PCT/US2003/020707 WO2004006890A1 (en) 2002-07-15 2003-06-30 Non-polymeric lipophilic pharmaceutical implant compositions for intraocular use

Publications (2)

Publication Number Publication Date
DE60318446D1 true DE60318446D1 (de) 2008-02-14
DE60318446T2 DE60318446T2 (de) 2008-05-21

Family

ID=30115932

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60318446T Expired - Lifetime DE60318446T2 (de) 2002-07-15 2003-06-30 Nichtpolymere lipophile pharmazeutische implantat-zusammensetzungen für die intraokulare anwendung

Country Status (18)

Country Link
US (2) US7678827B2 (de)
EP (1) EP1521573B1 (de)
JP (1) JP4463681B2 (de)
KR (1) KR101003518B1 (de)
CN (1) CN100355455C (de)
AT (1) ATE382330T1 (de)
AU (1) AU2003248777B2 (de)
BR (1) BR0312635A (de)
CA (1) CA2491313C (de)
CY (1) CY1107166T1 (de)
DE (1) DE60318446T2 (de)
DK (1) DK1521573T3 (de)
ES (1) ES2295647T3 (de)
MX (1) MXPA05000632A (de)
PL (1) PL206594B1 (de)
PT (1) PT1521573E (de)
WO (1) WO2004006890A1 (de)
ZA (2) ZA200410096B (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6955661B1 (en) * 1999-01-25 2005-10-18 Atrium Medical Corporation Expandable fluoropolymer device for delivery of therapeutic agents and method of making
US7947015B2 (en) * 1999-01-25 2011-05-24 Atrium Medical Corporation Application of a therapeutic substance to a tissue location using an expandable medical device
US7431710B2 (en) 2002-04-08 2008-10-07 Glaukos Corporation Ocular implants with anchors and methods thereof
US20070184089A1 (en) * 2002-07-15 2007-08-09 Alcon, Inc. Non-Polymeric Lipophilic Pharmaceutical Implant Compositions for Intraocular Use
DK1521573T3 (da) * 2002-07-15 2008-03-25 Alcon Inc Ikke-polymere, lipofile, farmaceutiske implantatsammensætninger til intrakulær anvendelse
US20050244463A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Sustained release intraocular implants and methods for treating ocular vasculopathies
JP5097883B2 (ja) * 2004-09-02 2012-12-12 株式会社 神崎高級工機製作所 油圧駆動車両
US9012506B2 (en) 2004-09-28 2015-04-21 Atrium Medical Corporation Cross-linked fatty acid-based biomaterials
US8962023B2 (en) 2004-09-28 2015-02-24 Atrium Medical Corporation UV cured gel and method of making
US9000040B2 (en) 2004-09-28 2015-04-07 Atrium Medical Corporation Cross-linked fatty acid-based biomaterials
ATE425740T1 (de) * 2005-09-21 2009-04-15 Univ Aston Chronotherapeutisches okulares abgabesystem aus einer kombination von prostaglandinen und einem betablocker zur behandlung von primarem glaukom
US9278161B2 (en) 2005-09-28 2016-03-08 Atrium Medical Corporation Tissue-separating fatty acid adhesion barrier
US9427423B2 (en) 2009-03-10 2016-08-30 Atrium Medical Corporation Fatty-acid based particles
US9173773B2 (en) * 2006-06-21 2015-11-03 Johnson & Johnson Vision Care, Inc. Punctal plugs for the delivery of active agents
US20080045911A1 (en) * 2006-06-21 2008-02-21 Borgia Maureen J Punctal plugs for the delivery of active agents
US9474645B2 (en) * 2006-06-21 2016-10-25 Johnson & Johnson Vision Care, Inc. Punctal plugs for the delivery of active agents
UY30883A1 (es) 2007-01-31 2008-05-31 Alcon Res Tapones punctales y metodos de liberacion de agentes terapeuticos
WO2009035562A2 (en) * 2007-09-07 2009-03-19 Qlt Plug Delivery, Inc Drug cores for sustained release of therapeutic agents
TWI451862B (zh) * 2007-10-09 2014-09-11 Alcon Res Ltd 用於眼睛注射的熱係數驅動藥丸尺寸
TWI498136B (zh) * 2007-10-09 2015-09-01 Alcon Res Ltd 用於遞送速率及溫度相依性物質至眼睛的注射器及其製備方法
JP2010104632A (ja) 2008-10-31 2010-05-13 Hoya Corp ゲル化能を有する眼科用組成物
US9095506B2 (en) 2008-11-17 2015-08-04 Allergan, Inc. Biodegradable alpha-2 agonist polymeric implants and therapeutic uses thereof
US8632511B2 (en) * 2009-05-06 2014-01-21 Alcon Research, Ltd. Multiple thermal sensors in a multiple processor environment for temperature control in a drug delivery device
US10206813B2 (en) 2009-05-18 2019-02-19 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
US20110038910A1 (en) 2009-08-11 2011-02-17 Atrium Medical Corporation Anti-infective antimicrobial-containing biomaterials
EP2498783B1 (de) 2009-11-09 2018-08-22 Allergan, Inc. Zusammensetzungen und verfahren zur stimulation des haarwuchses
US8177747B2 (en) * 2009-12-22 2012-05-15 Alcon Research, Ltd. Method and apparatus for drug delivery
SI2515887T1 (sl) * 2009-12-22 2018-10-30 Ucb Biopharma Sprl Polivinilpirolidon za stabilizacijo trdne disperzije nekristalinične oblike rotigotina
WO2012009707A2 (en) 2010-07-16 2012-01-19 Atrium Medical Corporation Composition and methods for altering the rate of hydrolysis of cured oil-based materials
DE102011016277B4 (de) * 2011-04-06 2013-02-21 Heraeus Medical Gmbh Plastisch verformbares, biodegradierbares Hämostyptikum und Verfahren zum Formen eines solchen
US9867880B2 (en) 2012-06-13 2018-01-16 Atrium Medical Corporation Cured oil-hydrogel biomaterial compositions for controlled drug delivery
CA2901280A1 (en) 2013-02-15 2014-08-21 Allergan, Inc. Sustained drug delivery implant
WO2015046281A1 (ja) * 2013-09-26 2015-04-02 参天製薬株式会社 安定化された２－アミノ－３－（４－ブロモベンゾイル）フェニル酢酸含有水性組成物
WO2015184173A1 (en) 2014-05-29 2015-12-03 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
WO2017040853A1 (en) 2015-09-02 2017-03-09 Glaukos Corporation Drug delivery implants with bi-directional delivery capacity
US11564833B2 (en) 2015-09-25 2023-01-31 Glaukos Corporation Punctal implants with controlled drug delivery features and methods of using same
WO2017184881A1 (en) 2016-04-20 2017-10-26 Harold Alexander Heitzmann Bioresorbable ocular drug delivery device
CA3038115A1 (en) * 2016-09-30 2018-04-05 Mati Therapeutics Inc. Ophthalmic drug sustained release formulation and uses thereof
WO2018229653A1 (en) 2017-06-13 2018-12-20 Novartis Ag Intraocular lens compositions
RU2675691C1 (ru) * 2017-09-14 2018-12-21 Федеральное Государственное бюджетное образовательное учреждение высшего образования Дагестанский государственный медицинский университет Министерства здравоохранения Российской Федерации Способ длительной перфузии субтенонового пространства лекарственными средствами

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4014335A (en) 1975-04-21 1977-03-29 Alza Corporation Ocular drug delivery device
JPS6042766B2 (ja) 1978-12-09 1985-09-25 日本化薬株式会社 基剤
US4797288A (en) 1984-10-05 1989-01-10 Warner-Lambert Company Novel drug delivery system
GB8524421D0 (en) 1985-10-03 1985-11-06 Boots Co Plc Therapeutic agents
US4997652A (en) 1987-12-22 1991-03-05 Visionex Biodegradable ocular implants
US4853224A (en) 1987-12-22 1989-08-01 Visionex Biodegradable ocular implants
JP2893191B2 (ja) 1988-11-08 1999-05-17 武田薬品工業株式会社 放出制御性マトリックス剤
US5015474A (en) * 1988-11-22 1991-05-14 Parnell Pharmaceuticals, Inc. Composition for imparting moisture to a substrate
CA2045469A1 (en) * 1989-02-17 1990-08-18 Alan L. Weiner Lipid excipient for nasal delivery and topical application
US5164188A (en) 1989-11-22 1992-11-17 Visionex, Inc. Biodegradable ocular implants
US5660851A (en) 1989-12-26 1997-08-26 Yissum Research Development Company Of The Hebrew Univ. Of Jerusalem Ocular inserts
JPH05507683A (ja) 1990-04-27 1993-11-04 アラーガン、インコーポレイテッド ポリマードラッグデリバリーシステム
IE65045B1 (en) 1990-04-28 1995-10-04 Takeda Chemical Industries Ltd Granulated preparations and method of producing the same
US5378475A (en) 1991-02-21 1995-01-03 University Of Kentucky Research Foundation Sustained release drug delivery devices
DE69231359T2 (de) 1991-05-13 2001-02-08 Boots Co Ltd Ibuprofen-salz enthaltende pharmazeutische zusammensetzung
US5629019A (en) * 1992-02-27 1997-05-13 Alza Corporation Formulations with hydrophobic permeation enhancers
US5178635A (en) 1992-05-04 1993-01-12 Allergan, Inc. Method for determining amount of medication in an implantable device
WO1994005257A1 (en) 1992-09-08 1994-03-17 Allergan, Inc. Sustained release of ophthalmic drugs from a soluble polymer drug delivery vehicle
WO1995003009A1 (en) 1993-07-22 1995-02-02 Oculex Pharmaceuticals, Inc. Method of treatment of macular degeneration
US5433951A (en) 1993-10-13 1995-07-18 Bristol-Myers Squibb Company Sustained release formulation containing captopril and method
US5443505A (en) * 1993-11-15 1995-08-22 Oculex Pharmaceuticals, Inc. Biocompatible ocular implants
US5773021A (en) 1994-03-14 1998-06-30 Vetoquinol S.A. Bioadhesive ophthalmic insert
CA2119109C (en) 1994-03-15 2002-11-12 Florian Gurtler Bioadhesive ophthalmic insert
JP4259610B2 (ja) 1994-04-08 2009-04-30 キューエルティー・ユーエスエイ・インコーポレーテッド 液体デリバリー組成物
US6190691B1 (en) 1994-04-12 2001-02-20 Adolor Corporation Methods for treating inflammatory conditions
US5466233A (en) 1994-04-25 1995-11-14 Escalon Ophthalmics, Inc. Tack for intraocular drug delivery and method for inserting and removing same
AUPM897594A0 (en) 1994-10-25 1994-11-17 Daratech Pty Ltd Controlled release container
DE69529572T2 (de) 1994-11-10 2003-06-18 Univ Kentucky Res Foundation L Implantierbare wiederauffüllbare vorrichtung mit gesteuerter freisetzung zur verabreichung von arzneistoffen unmittelbar an einen inneren teil des körpers
US5725493A (en) 1994-12-12 1998-03-10 Avery; Robert Logan Intravitreal medicine delivery
US5718922A (en) 1995-05-31 1998-02-17 Schepens Eye Research Institute, Inc. Intravitreal microsphere drug delivery and method of preparation
US5869079A (en) 1995-06-02 1999-02-09 Oculex Pharmaceuticals, Inc. Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents
US5773019A (en) 1995-09-27 1998-06-30 The University Of Kentucky Research Foundation Implantable controlled release device to deliver drugs directly to an internal portion of the body
US5736152A (en) 1995-10-27 1998-04-07 Atrix Laboratories, Inc. Non-polymeric sustained release delivery system
WO1997018817A1 (fr) 1995-11-20 1997-05-29 Kiyoshi Kita Preparation externe contenant de la vitamine d ou de la vitamine k
US5797898A (en) 1996-07-02 1998-08-25 Massachusetts Institute Of Technology Microchip drug delivery devices
JP2001515491A (ja) * 1997-03-12 2001-09-18 アボツト・ラボラトリーズ 親油性化合物の投与のための親油性二成分系
US6143276A (en) 1997-03-21 2000-11-07 Imarx Pharmaceutical Corp. Methods for delivering bioactive agents to regions of elevated temperatures
US6120751A (en) 1997-03-21 2000-09-19 Imarx Pharmaceutical Corp. Charged lipids and uses for the same
JP2001513369A (ja) 1997-08-11 2001-09-04 アラーガン・セイルズ・インコーポレイテッド 改善された生物適合性を有する無菌の生物侵食性の移植デバイスおよび方法
IL121647A (en) * 1997-08-28 2001-07-24 Pharmateam Dev Ltd Pharmaceutical compositions for the treatment of ocular inflammation comprising dexamethasone palmitate
US5902598A (en) 1997-08-28 1999-05-11 Control Delivery Systems, Inc. Sustained release drug delivery devices
US6099853A (en) * 1997-09-04 2000-08-08 Protein Express Vaginal suppository vaccine for urogenital infections
US5891476A (en) * 1997-12-22 1999-04-06 Reo; Joe P. Tastemasked pharmaceutical system
DE19804310A1 (de) * 1998-02-04 1999-08-05 Aventis Res & Tech Gmbh & Co Spiroverbindungen und deren Verwendung
AU6608701A (en) * 2000-06-21 2002-01-02 Audit Institute For Medical Services And Quality Assurance Gmbh Pharmaceutical preparations containing cyclosporines and neutral oils
DE10030378A1 (de) * 2000-06-21 2002-03-14 Audit Inst For Medical Service Neue pharmazeutische Zusammensetzung zur topischen Anwendung von wasserunlöslichen und/oder schwer wasserlöslichen Wirkstoffen
AR038628A1 (es) 2002-03-04 2005-01-19 Novartis Ag Composicion oftalmica
DK1521573T3 (da) * 2002-07-15 2008-03-25 Alcon Inc Ikke-polymere, lipofile, farmaceutiske implantatsammensætninger til intrakulær anvendelse
US7297709B2 (en) * 2003-05-22 2007-11-20 Abbott Laboratories Indazole, benzisoxazole, and benzisothiazole kinase inhibitors

Also Published As

Publication number Publication date
EP1521573B1 (de) 2008-01-02
CY1107166T1 (el) 2012-10-24
DE60318446T2 (de) 2008-05-21
JP4463681B2 (ja) 2010-05-19
ATE382330T1 (de) 2008-01-15
ZA200410095B (en) 2006-07-26
CA2491313C (en) 2011-05-24
JP2006500328A (ja) 2006-01-05
ES2295647T3 (es) 2008-04-16
WO2004006890A1 (en) 2004-01-22
CN1668277A (zh) 2005-09-14
US7678827B2 (en) 2010-03-16
KR20050023409A (ko) 2005-03-09
MXPA05000632A (es) 2005-03-31
CA2491313A1 (en) 2004-01-22
PL206594B1 (pl) 2010-08-31
PL374743A1 (en) 2005-10-31
US8178576B2 (en) 2012-05-15
AU2003248777B2 (en) 2008-02-14
PT1521573E (pt) 2008-02-08
US20040013704A1 (en) 2004-01-22
EP1521573A1 (de) 2005-04-13
US20080241224A1 (en) 2008-10-02
BR0312635A (pt) 2005-04-19
AU2003248777A1 (en) 2004-02-02
KR101003518B1 (ko) 2010-12-30
CN100355455C (zh) 2007-12-19
ZA200410096B (en) 2006-07-26
DK1521573T3 (da) 2008-03-25

Similar Documents

Publication Publication Date Title
DE60318446D1 (de) Nichtpolymere lipophile pharmazeutische implantat-zusammensetzungen für die intraokulare anwendung
DE50109908D1 (de) Knochenimplantat, insbesondere zwischenwirbelimplantat
DK1401501T3 (da) Orale farmaceutiske sammensætninger med modificeret frigivelse af den aktive ingrediens
BR0211102B1 (pt) método para a produção de uma prótese dentária.
ECSP066860A (es) Formulaciones de matriz oral que comprenden licarbazepina
BR0208309B1 (pt) derivados de arilisoxazolina, processos para a sua preparaÇço e sua aplicaÇço como composiÇÕes praguicidas.
NO20054214D0 (no) Iminoeterderivatforbindelser og legemidler inneholdende forbindelsene som den aktive bestanddel
PT1121127E (pt) Composicoes farmaceuticas orais contendo buprenorfina
BRPI0311189B8 (pt) composições farmacêuticas contendo polimorfo a de flibanserin, bem como seu uso
DE59907481D1 (de) Kontrolliert freisetzende pharmazeutische zusammensetzung mit tilidinmesylat als wirkstoff
ECSP066872A (es) Tabletas desintegrantes que comprenden licarbazepina
NO20063293L (no) Farmasoytiske forbindelser
BR0205307B1 (pt) máquina de semear, e, unidade de plantio para uma máquina de semear.
CY1108413T1 (el) Ενεσιμη φαρμακευτικη συνθεση που περιλαμβανει αιθανολη για την αγωγη των δισκοπαθειων
BR0207066A (pt) Derivados do 2h-1-benzopirano - processos para sua preparação e composições farmacêuticas a partir deles
BRPI0417265A (pt) composição farmacêutica compreendendo um princìpio ativo e sulfobetaìna
IT1320834B1 (it) Dispositivo implantare per protesi dentali.
ITTO20030879A1 (it) Composizione insetticida microincapsulata.
DE602004022420D1 (de) Pharmazeutische zusammensetzungen, die cyclische somatostatinanaloga enthalten
IL176208A0 (en) Uv-stable, liquid or semi-solid transdermal administration form comprising a photosensitive active ingredient
ITRM20030074A0 (it) Formulazioni semisolide a rilascio immediato intese per la somministrazione orale di farmaci.
DE10193800D2 (de) Implantierbare Prothese für intravaskuläre Anwendungen
ITRM20020314A0 (it) Impianto penieno apicale per falloplastica di ingrandimento.
FR2862523B1 (fr) Prothese mammaire implantable
ES1053198Y (es) Implante dental.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition