DE3277030D1 - Method and apparatus for the determination of species in solution with an optical wave-guide - Google Patents

Method and apparatus for the determination of species in solution with an optical wave-guide

Info

Publication number
DE3277030D1
DE3277030D1 DE8282201107T DE3277030T DE3277030D1 DE 3277030 D1 DE3277030 D1 DE 3277030D1 DE 8282201107 T DE8282201107 T DE 8282201107T DE 3277030 T DE3277030 T DE 3277030T DE 3277030 D1 DE3277030 D1 DE 3277030D1
Authority
DE
Germany
Prior art keywords
species
determination
guide
solution
optical wave
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8282201107T
Other languages
English (en)
Inventor
Timothy Carter
Claus Dahne
John F Place
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Prutec Ltd
Original Assignee
Battelle Memorial Institute Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8188676&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3277030(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Battelle Memorial Institute Inc filed Critical Battelle Memorial Institute Inc
Application granted granted Critical
Publication of DE3277030D1 publication Critical patent/DE3277030D1/de
Expired legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N21/648Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N21/6452Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G01N33/553Metal or metal coated
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/805Optical property
DE8282201107T 1981-09-18 1982-09-08 Method and apparatus for the determination of species in solution with an optical wave-guide Expired DE3277030D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP81810385 1981-09-18

Publications (1)

Publication Number Publication Date
DE3277030D1 true DE3277030D1 (en) 1987-09-24

Family

ID=8188676

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8282201107T Expired DE3277030D1 (en) 1981-09-18 1982-09-08 Method and apparatus for the determination of species in solution with an optical wave-guide

Country Status (10)

Country Link
US (1) US4608344A (de)
EP (1) EP0075353B1 (de)
JP (1) JPS58501481A (de)
AU (1) AU557816B2 (de)
CA (1) CA1189348A (de)
DE (1) DE3277030D1 (de)
DK (1) DK166639C (de)
ES (2) ES8401625A1 (de)
FI (1) FI76432C (de)
WO (1) WO1983001112A1 (de)

Families Citing this family (158)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4582809A (en) * 1982-06-14 1986-04-15 Myron J. Block Apparatus including optical fiber for fluorescence immunoassay
US4447546A (en) * 1982-08-23 1984-05-08 Myron J. Block Fluorescent immunoassay employing optical fiber in capillary tube
DE3376685D1 (en) * 1982-12-21 1988-06-23 Ares Serono Nv Assay technique
GB8314523D0 (en) * 1983-05-25 1983-06-29 Lowe C R Diagnostic device
US4558014A (en) * 1983-06-13 1985-12-10 Myron J. Block Assay apparatus and methods
DE3344019C2 (de) * 1983-12-06 1995-05-04 Max Planck Gesellschaft Vorrichtung zur optischen Messung der Konzentration einer in einer Probe enthaltenen Komponente
AU581669B2 (en) * 1984-06-13 1989-03-02 Applied Research Systems Ars Holding N.V. Photometric instruments, their use in methods of optical analysis, and ancillary devices therefor
USRE33581E (en) * 1984-06-25 1991-04-30 Immunoassay using optical interference detection
US4647544A (en) * 1984-06-25 1987-03-03 Nicoli David F Immunoassay using optical interference detection
GB8423204D0 (en) * 1984-09-14 1984-10-17 Comtech Res Unit Assay technique and equipment
US4668636A (en) * 1984-11-06 1987-05-26 Battelle Memorial Institute Analytical assembly usable in apparatuses for optically determining species in solution
DE3481644D1 (de) * 1984-12-10 1990-04-19 Prutec Ltd Verfahren zum optischen nachweis von parametern von substanzen in einem fluessigen analyt.
EP0185126B1 (de) * 1984-12-10 1989-11-15 Prutec Limited Optischer Messfühler und Vorrichtung zur optischen Bestimmung von gelösten Substanzen
JPH0660876B2 (ja) * 1985-03-30 1994-08-10 株式会社東芝 分析装置
GB8509491D0 (en) * 1985-04-12 1985-05-15 Plessey Co Plc Optic waveguide biosensors
CH665033A5 (fr) * 1985-07-01 1988-04-15 Prutec Ltd Guide d'onde utilisable comme sonde optique dans l'analyse spectroscopique a reflexion interne.
DE3689095T2 (de) * 1985-07-31 1994-01-27 Ciba Corning Diagnostics Corp Dielektrischer Wellenleiter zur Verwendung in einem Analyseverfahren.
US4716121A (en) * 1985-09-09 1987-12-29 Ord, Inc. Fluorescent assays, including immunoassays, with feature of flowing sample
JPS6275230A (ja) * 1985-09-26 1987-04-07 チバ−ガイギ− アクチエンゲゼルシヤフト 分析法
DE3543108A1 (de) * 1985-12-06 1987-06-19 Strahlen Umweltforsch Gmbh Verfahren zur messung der wechselwirkung im wand/fluid-bereich
US4945245A (en) * 1986-01-14 1990-07-31 Levin Herman W Evanescent wave background fluorescence/absorbance detection
JPH01502131A (ja) * 1986-01-14 1989-07-27 レビン ハーマン ダブリュ エバネッセント波背景螢光/吸光度の検出
US4852967A (en) * 1986-03-25 1989-08-01 Ciba Corning Diagnostics Corp. Evanescent wave sensors
EP0245206A1 (de) * 1986-05-05 1987-11-11 IntraCel Corporation Analytisches Verfahren zum Nachweis und zur Messung einer spezifisch sequentierten Nukleinsäure
JP2591750B2 (ja) * 1986-06-26 1997-03-19 オ−ソ・ダイアグノステイツク・システムズ・インコ−ポレ−テツド 免疫分析システム
BE1000572A4 (fr) * 1987-05-20 1989-02-07 Block Myron J Cellule rta, appareil et procede pour titrer un polynucleotide dans un liquide.
US4834496A (en) * 1987-05-22 1989-05-30 American Telephone And Telegraph Company, At&T Bell Laboratories Optical fiber sensors for chemical detection
AT389590B (de) * 1987-05-27 1989-12-27 Avl Verbrennungskraft Messtech Verfahren zur kontinuierlichen, quantitativen bestimmung von schwefeldioxid und anordnung zur durchfuehrung des verfahrens
US4909990A (en) * 1987-09-02 1990-03-20 Myron J. Block Immunoassay apparatus
WO1989007254A1 (en) * 1988-01-28 1989-08-10 Spectran Corporation Infrared transmitting probe and assays using same
US4827121A (en) * 1988-02-24 1989-05-02 Measurex Corporation System for detecting chemical changes in materials by embedding in materials an unclad fiber optic sensor section
US4913519A (en) * 1988-03-04 1990-04-03 Fiberchem Inc. Optical sensor for the detection of ice formation and other chemical species
GB8807488D0 (en) * 1988-03-29 1988-05-05 Ares Serono Res & Dev Ltd Method of assay
US4893894A (en) * 1988-04-29 1990-01-16 Mine Safety Appliances Company Evanescent sensor
GB8817710D0 (en) * 1988-07-25 1988-09-01 Ares Serono Res & Dev Ltd Method of assay
GB2223841A (en) * 1988-08-31 1990-04-18 Red Kite Tech Parameter measurement using refractive index change
US4940328A (en) * 1988-11-04 1990-07-10 Georgia Tech Research Corporation Optical sensing apparatus and method
SE8902043L (sv) * 1988-11-10 1990-05-11 Pharmacia Ab Foerfarande foer karakterisering av makromolekyler
US4892383A (en) * 1989-02-17 1990-01-09 Fiberchem Inc. Reservoir fiber optic chemical sensors
US5266486A (en) * 1989-05-12 1993-11-30 Nvl Photronics Corporation Method and apparatus for detecting biological activities in a specimen
US5082629A (en) * 1989-12-29 1992-01-21 The Board Of The University Of Washington Thin-film spectroscopic sensor
US5377008A (en) * 1990-09-20 1994-12-27 Battelle Memorial Institute Integrated optical compensating refractometer apparatus
CA2073344C (en) * 1990-11-13 2001-08-21 Myron J. Block Fluorescence assay apparatus
US5212099A (en) * 1991-01-18 1993-05-18 Eastman Kodak Company Method and apparatus for optically measuring concentration of an analyte
US5192510A (en) * 1991-01-30 1993-03-09 E. I. Du Pont De Nemours And Company Apparatus for performing fluorescent assays which separates bulk and evanescent fluorescence
CA2069537A1 (en) * 1991-06-07 1992-12-08 Thomas A. Cook Multiple output referencing system for evanescent wave sensor
FR2685086A1 (fr) * 1991-12-17 1993-06-18 Devienne Marcel Procede d'observation sequentielle des etats successifs d'une reaction chimique.
EP1130116A3 (de) * 1992-04-06 2004-01-14 Abbott Laboratories Methode und Gerät zur Detektion von Nukleinsäuren unter Verwendung von totaler interner Reflektion
US5777726A (en) * 1992-05-12 1998-07-07 Raytheon Company Spectrophotometric supercritical fluid contamination monitor
GB9212305D0 (en) * 1992-06-10 1992-07-22 Applied Research Systems Sensor for optical assay
US5326531A (en) * 1992-12-11 1994-07-05 Puritan-Bennett Corporation CO2 sensor using a hydrophilic polyurethane matrix and process for manufacturing
DE4307042A1 (de) * 1993-03-05 1994-09-08 S & L Ges Fuer Wissenschaftlic Verfahren zum optischen qualitativen und quantitativen Nachweis von Molekülen, Biomolekülen und Mikroorganismen
US5448071A (en) * 1993-04-16 1995-09-05 Bruce W. McCaul Gas spectroscopy
US5625189A (en) * 1993-04-16 1997-04-29 Bruce W. McCaul Gas spectroscopy
US5413939A (en) * 1993-06-29 1995-05-09 First Medical, Inc. Solid-phase binding assay system for interferometrically measuring analytes bound to an active receptor
US6287850B1 (en) * 1995-06-07 2001-09-11 Affymetrix, Inc. Bioarray chip reaction apparatus and its manufacture
US5599668A (en) * 1994-09-22 1997-02-04 Abbott Laboratories Light scattering optical waveguide method for detecting specific binding events
US5814565A (en) * 1995-02-23 1998-09-29 University Of Utah Research Foundation Integrated optic waveguide immunosensor
US5922534A (en) 1995-03-28 1999-07-13 Hewlett-Packard Company Dry biochemical assay plate and method for making the same
US5633724A (en) * 1995-08-29 1997-05-27 Hewlett-Packard Company Evanescent scanning of biochemical array
EP0957750A1 (de) * 1995-10-23 1999-11-24 Cytometrics, Inc. Verfahren und vorrichtung zur analyse reflektierter bilder
DE69733650T2 (de) * 1996-03-01 2006-04-20 Beckman Coulter, Inc., Fullerton System zum simultanen Durchführen einer Vielzahl von Ligandenbindungs-Untersuchungen
US5854863A (en) * 1996-03-15 1998-12-29 Erb; Judith Surface treatment and light injection method and apparatus
GB9609653D0 (en) * 1996-05-09 1996-07-10 Applied Research Ars Holding N Method of assay
US6342349B1 (en) 1996-07-08 2002-01-29 Burstein Technologies, Inc. Optical disk-based assay devices and methods
US20050214827A1 (en) * 1996-07-08 2005-09-29 Burstein Technologies, Inc. Assay device and method
AU725065B2 (en) 1996-07-08 2000-10-05 Burstein Technologies, Inc. Cleavable signal element device and method
US6331275B1 (en) 1996-07-08 2001-12-18 Burstein Technologies, Inc. Spatially addressable, cleavable reflective signal elements, assay device and method
US7335164B2 (en) 1996-07-15 2008-02-26 Ntc Technology, Inc. Multiple function airway adapter
US6815211B1 (en) 1998-08-04 2004-11-09 Ntc Technology Oxygen monitoring methods and apparatus (I)
US6325978B1 (en) 1998-08-04 2001-12-04 Ntc Technology Inc. Oxygen monitoring and apparatus
US20070225612A1 (en) * 1996-07-15 2007-09-27 Mace Leslie E Metabolic measurements system including a multiple function airway adapter
US5982534A (en) * 1997-06-18 1999-11-09 The Regents Of The University Of California Specimen illumination apparatus with optical cavity for dark field illumination
US6222619B1 (en) * 1997-09-18 2001-04-24 University Of Utah Research Foundation Diagnostic device and method
DE19747572C1 (de) * 1997-10-28 1999-04-08 Inst Chemo Biosensorik Vorrichtung und Verfahren zur Durchführung von Fluoreszenzimmuntests
US6224830B1 (en) * 1998-01-30 2001-05-01 The Governors Of The University Of Alberta Absorbance cell for microfluid devices
US6326213B1 (en) * 1998-02-09 2001-12-04 The Boards Of Govenors For Higher Education, State Of Rhode Island And Providence Plantations Acoustic standing-wave enhancement of a fiber-optic Salmonella biosensor
US6300082B1 (en) * 1998-03-20 2001-10-09 Ia, Inc. Method and apparatus for measurement of the effect of test compounds on signal transduction at the level of biological receptors
US6251688B1 (en) * 1998-03-20 2001-06-26 Ia, Inc. Method and apparatus for measurement of binding between a protein and a nucleotide
ES2247820T3 (es) * 1998-05-25 2006-03-01 Jennissen, Herbert P. Analizador de cizallamiento de circulacion para moleculas biologicas activas en capas de liquidos en superficies, procedimiento para los analisis de un liquido y procedimiento para determinar un espesor de una capa de liquido ultrafina.
US6429023B1 (en) 1998-07-20 2002-08-06 Shayda Technologies, Inc. Biosensors with polymeric optical waveguides
CA2338401A1 (en) * 1998-07-21 2000-02-03 Burstein Laboratories, Inc Optical disc-based assay devices and methods
US6266998B1 (en) * 1999-04-01 2001-07-31 DRäGERWERK AKTIENGESELLSCHAFT System for measuring the concentration of gases
EE04249B1 (et) * 1999-04-21 2004-02-16 Asper O� Meetod biopolümeermaatriksi lugemiseks ja fluorestsentsdetektor
US8111401B2 (en) 1999-11-05 2012-02-07 Robert Magnusson Guided-mode resonance sensors employing angular, spectral, modal, and polarization diversity for high-precision sensing in compact formats
US7167615B1 (en) 1999-11-05 2007-01-23 Board Of Regents, The University Of Texas System Resonant waveguide-grating filters and sensors and methods for making and using same
US6399295B1 (en) 1999-12-17 2002-06-04 Kimberly-Clark Worldwide, Inc. Use of wicking agent to eliminate wash steps for optical diffraction-based biosensors
CA2403427C (en) * 2000-03-22 2013-04-30 M. Cynthia Goh Method and apparatus for assay for multiple analytes
US6927851B2 (en) * 2000-03-31 2005-08-09 Neogen Corporation Methods and apparatus to improve the sensitivity and reproducibility of bioluminescent analytical methods
WO2002033005A2 (en) * 2000-10-19 2002-04-25 Trans Photonics, L.L.C. Novel substituted-polyaryl chromophoric compounds
US7175980B2 (en) * 2000-10-30 2007-02-13 Sru Biosystems, Inc. Method of making a plastic colorimetric resonant biosensor device with liquid handling capabilities
US7217574B2 (en) * 2000-10-30 2007-05-15 Sru Biosystems, Inc. Method and apparatus for biosensor spectral shift detection
US7306827B2 (en) * 2000-10-30 2007-12-11 Sru Biosystems, Inc. Method and machine for replicating holographic gratings on a substrate
US7118710B2 (en) * 2000-10-30 2006-10-10 Sru Biosystems, Inc. Label-free high-throughput optical technique for detecting biomolecular interactions
US7371562B2 (en) * 2000-10-30 2008-05-13 Sru Biosystems, Inc. Guided mode resonant filter biosensor using a linear grating surface structure
US7875434B2 (en) * 2000-10-30 2011-01-25 Sru Biosystems, Inc. Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor
US20030113766A1 (en) * 2000-10-30 2003-06-19 Sru Biosystems, Llc Amine activated colorimetric resonant biosensor
US6951715B2 (en) * 2000-10-30 2005-10-04 Sru Biosystems, Inc. Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements
US7264973B2 (en) * 2000-10-30 2007-09-04 Sru Biosystems, Inc. Label-free methods for performing assays using a colorimetric resonant optical biosensor
US7070987B2 (en) * 2000-10-30 2006-07-04 Sru Biosystems, Inc. Guided mode resonant filter biosensor using a linear grating surface structure
US7023544B2 (en) 2000-10-30 2006-04-04 Sru Biosystems, Inc. Method and instrument for detecting biomolecular interactions
US7575939B2 (en) * 2000-10-30 2009-08-18 Sru Biosystems, Inc. Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements
US7142296B2 (en) * 2000-10-30 2006-11-28 Sru Biosystems, Inc. Method and apparatus for detecting biomolecular interactions
US20030092075A1 (en) * 2000-10-30 2003-05-15 Sru Biosystems, Llc Aldehyde chemical surface activation processes and test methods for colorimetric resonant sensors
US7615339B2 (en) * 2000-10-30 2009-11-10 Sru Biosystems, Inc. Method for producing a colorimetric resonant reflection biosensor on rigid surfaces
US7101660B2 (en) * 2000-10-30 2006-09-05 Sru Biosystems, Inc. Method for producing a colorimetric resonant reflection biosensor on rigid surfaces
US7202076B2 (en) * 2000-10-30 2007-04-10 Sru Biosystems, Inc. Label-free high-throughput optical technique for detecting biomolecular interactions
US7153702B2 (en) 2000-10-30 2006-12-26 Sru Biosystems, Inc. Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor
US7300803B2 (en) * 2000-10-30 2007-11-27 Sru Biosystems, Inc. Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor
EP1410044A2 (de) * 2000-11-08 2004-04-21 Burstein Technologies, Inc. Interaktives system zur analyse biologischer proben und zur verarbeitung damit im zusammenhang stehender angaben und verwendung davon
US7087203B2 (en) * 2000-11-17 2006-08-08 Nagaoka & Co., Ltd. Methods and apparatus for blood typing with optical bio-disc
US7026131B2 (en) * 2000-11-17 2006-04-11 Nagaoka & Co., Ltd. Methods and apparatus for blood typing with optical bio-discs
US6760298B2 (en) * 2000-12-08 2004-07-06 Nagaoka & Co., Ltd. Multiple data layer optical discs for detecting analytes
WO2002046762A2 (en) * 2000-12-08 2002-06-13 Burstein Technologies, Inc. Optical disc assemblies for performing assays
EP2098854A1 (de) * 2001-01-23 2009-09-09 Dublin City University Lumineszenzbasierter Sensor
CN1639557A (zh) 2001-04-11 2005-07-13 伯斯坦技术公司 包括分析盘的多参数化验以及涉及该化验的方法
US20020171838A1 (en) * 2001-05-16 2002-11-21 Pal Andrew Attila Variable sampling control for rendering pixelization of analysis results in a bio-disc assembly and apparatus relating thereto
US7098041B2 (en) * 2001-12-11 2006-08-29 Kimberly-Clark Worldwide, Inc. Methods to view and analyze the results from diffraction-based diagnostics
US7102752B2 (en) * 2001-12-11 2006-09-05 Kimberly-Clark Worldwide, Inc. Systems to view and analyze the results from diffraction-based diagnostics
US7018842B2 (en) * 2002-02-28 2006-03-28 Agilent Technologies, Inc. Reading dry chemical arrays through the substrate
SG104963A1 (en) * 2002-04-03 2004-07-30 Ntu Ventures Private Ltd Fiber optic bio-sensor
US6620623B1 (en) * 2002-05-06 2003-09-16 The University Of Chicago Biochip reader with enhanced illumination and bioarray positioning apparatus
US20030224370A1 (en) * 2002-05-31 2003-12-04 William Rassman Method and apparatus for recognizing molecular compounds
US7927822B2 (en) 2002-09-09 2011-04-19 Sru Biosystems, Inc. Methods for screening cells and antibodies
US7429492B2 (en) * 2002-09-09 2008-09-30 Sru Biosystems, Inc. Multiwell plates with integrated biosensors and membranes
CN1823085A (zh) * 2003-05-28 2006-08-23 专家技术公司 识别分子化合物的方法和设备
JP4130391B2 (ja) * 2003-08-28 2008-08-06 富士通株式会社 被検体評価装置、被検体評価方法および被検体評価装置の製造方法
WO2005022155A1 (ja) * 2003-08-29 2005-03-10 Kabushiki Kaisha Toshiba 発色試薬、濃度測定用キット、濃度測定方法及びそれに用いるセンサチップ
AU2003267176A1 (en) * 2003-09-12 2005-04-27 Maven Technologies, Llc Method and apparatus for recognizing molecular compounds
US8298780B2 (en) * 2003-09-22 2012-10-30 X-Body, Inc. Methods of detection of changes in cells
EP1680679A2 (de) * 2003-11-06 2006-07-19 SRU Biosystems Inc. Mit aminen in hoher dichte funktionalisierte oberfläche
SE529711C2 (sv) * 2006-03-22 2007-11-06 Aamic Ab Fluorescensläsare
US20070235397A1 (en) * 2006-03-30 2007-10-11 Wannop George M Storage bin and frame system
WO2008072156A2 (en) 2006-12-12 2008-06-19 Koninklijke Philips Electronics N. V. Microelectronic sensor device for detecting label particles
JP5238171B2 (ja) * 2007-03-14 2013-07-17 株式会社東芝 光導波路型抗体チップ
CA2683082A1 (en) * 2007-04-19 2008-10-30 Sru Biosystems, Inc. Method for employing a biosensor to detect small molecules that bind directly to immobilized targets
US9134307B2 (en) 2007-07-11 2015-09-15 X-Body, Inc. Method for determining ion channel modulating properties of a test reagent
CA2693700A1 (en) 2007-07-11 2009-01-15 Sru Biosystems, Inc. Methods for identifying modulators of ion channels
WO2009013706A2 (en) * 2007-07-26 2009-01-29 Koninklijke Philips Electronics N. V. Microelectronic sensor device for optical examinations with total internal reflection
JP4970217B2 (ja) * 2007-11-07 2012-07-04 株式会社東芝 物質の測定方法
US8257936B2 (en) 2008-04-09 2012-09-04 X-Body Inc. High resolution label free analysis of cellular properties
EP2304500A1 (de) * 2008-06-04 2011-04-06 SRU Biosystems, Inc. Detektion von promiskuitiven kleinen submikrometeraggregaten
US8331751B2 (en) * 2009-03-02 2012-12-11 mBio Diagnositcs, Inc. Planar optical waveguide with core of low-index-of-refraction interrogation medium
US9212995B2 (en) 2009-03-02 2015-12-15 Mbio Diagnostics, Inc. System and method for detecting multiple molecules in one assay
US8300993B2 (en) * 2009-03-02 2012-10-30 Mbio Diagnostics, Inc. Waveguide with integrated lens
US9658222B2 (en) 2009-03-02 2017-05-23 Mbio Diagnostics, Inc. Planar waveguide based cartridges and associated methods for detecting target analyte
CN102460171A (zh) * 2009-05-15 2012-05-16 Sru生物系统公司 细胞群和混合细胞群变化的检测
JP4948624B2 (ja) * 2010-05-06 2012-06-06 シャープ株式会社 濁度検知器
TW201217783A (en) 2010-09-15 2012-05-01 Mbio Diagnostics Inc System and method for detecting multiple molecules in one assay
US8218133B2 (en) * 2010-09-16 2012-07-10 Sondex Limited Refractive index tool and method
KR101188344B1 (ko) * 2011-01-14 2012-10-05 광주과학기술원 클래딩층 내 금속 나노 입자가 도핑된 광섬유, 코어리스 광섬유 및 이들의 제조 방법
EP2699906B1 (de) 2011-04-20 2017-11-29 Access Medical Systems, Ltd. Cyclische amplifikation lumineszenter polymere
EP2522276A1 (de) 2011-05-13 2012-11-14 General Electric Company Flugbahnadapter und Gasanalysegerät zum Messen der Sauerstoffkonzentration für ein Atemgas
EP2748584B1 (de) * 2011-11-03 2021-11-24 Siemens Healthineers Nederland B.V. Parallele optische analysen einer probe
US20160131583A1 (en) * 2013-06-03 2016-05-12 Ventana Medical Systems, Inc. Fluorescence imaging system for tissue detection
CN105445253B (zh) * 2015-11-12 2018-05-18 北京农业智能装备技术研究中心 一种用于检测水中抗生素浓度的设备
TWI565941B (zh) * 2016-01-07 2017-01-11 國立交通大學 光學量測系統及其濃度感測裝置
US11054577B1 (en) * 2017-10-31 2021-07-06 Shenzhen University Hybrid fiber coupler and manufacturing method thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3939350A (en) * 1974-04-29 1976-02-17 Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing total reflection for activation
US4050895A (en) * 1975-09-26 1977-09-27 Monsanto Research Corporation Optical analytical device, waveguide and method
US4321057A (en) * 1979-09-20 1982-03-23 Buckles Richard G Method for quantitative analysis using optical fibers

Also Published As

Publication number Publication date
JPS58501481A (ja) 1983-09-01
AU557816B2 (en) 1987-01-08
ES515787A0 (es) 1983-12-16
FI76432B (fi) 1988-06-30
EP0075353A1 (de) 1983-03-30
DK219683D0 (da) 1983-05-17
DK219683A (da) 1983-05-17
DK166639B (da) 1993-06-21
US4608344A (en) 1986-08-26
ES8401625A1 (es) 1983-12-16
WO1983001112A1 (en) 1983-03-31
EP0075353B1 (de) 1987-08-19
ES8405523A1 (es) 1984-06-01
FI831745L (fi) 1983-05-18
FI831745A0 (fi) 1983-05-18
AU8904182A (en) 1983-04-08
DK166639C (da) 1993-11-08
CA1189348A (en) 1985-06-25
JPH037270B2 (de) 1991-02-01
ES524166A0 (es) 1984-06-01
FI76432C (fi) 1988-10-10

Similar Documents

Publication Publication Date Title
DE3277030D1 (en) Method and apparatus for the determination of species in solution with an optical wave-guide
GB2069689B (en) Apparatus and method for optical clearance determination
DE3268128D1 (en) Method and device for the determination of biological components
GB2132348B (en) Method and apparatus for determining the presence of oxygen
ZA811173B (en) Photometric apparatus and method
DE3279451D1 (en) Optical imaging apparatus and method
GB2105195B (en) Apparatus for treating with light
GB2104656B (en) Sample handling method and apparatus
GB2069691B (en) Optical line width measuring apparatus and method
EP0167505A3 (en) Method and apparatus for level measurement with microwaves
GB2143965B (en) Optical waveguide splicing method and apparatus
DE3377592D1 (en) Light frequency change detecting method and apparatus
DE3380187D1 (en) Optical distance-measuring method and apparatus therefor
DE3366009D1 (en) Optical waveguide terminating apparatus and method
GB2055047B (en) Method and apparatus for circulating or pumping organo-biological liquids
EP0145343A3 (en) Optical fibre test method and apparatus for performing the method
GB2142280B (en) Process and apparatus for the colour-coding of optical waveguides
GB2081437B (en) Optical triangulation apparatus and method
GB2124365B (en) Optical inspection system and method
GB2157843B (en) Method and apparatus for inspecting the end of an optic connector
DE3172294D1 (en) Method and apparatus for determining the shape of objects
JPS571968A (en) Non-contact optical receiving method of and apparatus for microwave
JPS577841A (en) Method and device for repairing surface-injured glass vessel
JPS56132557A (en) Ion measuring apparatus and method
GB2128735B (en) Method and apparatus for optically measuring clearance change

Legal Events

Date Code Title Description
8363 Opposition against the patent
8327 Change in the person/name/address of the patent owner

Owner name: PRUTEC LTD., LONDON, GB

8328 Change in the person/name/address of the agent

Free format text: WEY, H., DIPL.-ING., PAT.-ANW., 8000 MUENCHEN

8331 Complete revocation