CN101516274B - Biopsy devices and related methods - Google Patents
Biopsy devices and related methods Download PDFInfo
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- CN101516274B CN101516274B CN2007800011907A CN200780001190A CN101516274B CN 101516274 B CN101516274 B CN 101516274B CN 2007800011907 A CN2007800011907 A CN 2007800011907A CN 200780001190 A CN200780001190 A CN 200780001190A CN 101516274 B CN101516274 B CN 101516274B
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Abstract
The present invention provides apparatus and methods to remove biopsy specimens from bone and/or associated bone marrow. A powered driver may rotate a biopsy needle at an optimum speed to obtain the biopsy specimen. A thread or a groove may be disposed on interior portions of the biopsy needle. The thread or groove may engage a biopsy specimen and enhance removal of a bone marrow core from cancellous bone. Manufacturing procedures are provided for bonding a single helical thread with interior portions of the biopsy needle. The apparatus may also include a biopsy sample ejector and/or ejector funnel. A biopsy needle set may include a cannula and a trocar with respective tips having optimum configurations, dimensions and/or orientations relative to each other to optimize penetration of a bone and/or bone marrow with minimum patient trauma and enhanced reliability of obtaining a biopsy specimen.
Description
Related application
It is that JIUYUE 12 day, in 2006 are called the U.S. Provisional Patent Application No.60/825 of " Apparatus andMethods for Biopsy and Aspiration of Bone Marrow ", 325 priority that the application requires the applying date.It is for reference that the content of this application is all incorporated this paper into.
The application require the applying date be April 4 in 2007 day, be called the U.S. Provisional Patent Application No.60/910 of " Powered DriverIntraosseous Device and Methods To Access Bone Marrow ", 122 priority.It is for reference that the content of this application is all incorporated this paper into.
Technical field
The present invention relates in general to the medical procedure for example suction and the biopsy of bone marrow, and equipment and the method relevant with tool kit with power drill/driver, connector assembly, aspiration needle, biopsy needle and corresponding medical procedures trays.
Background technology
It is very important to enter and take out bone marrow concerning many clinical conditions.In some cases, need treat disease to recover the hemocyte function with bone marrow or stem cell transplantation.These situations include but not limited to acute leukemia, cerebroma, breast carcinoma, Hokdkin disease, multiple myeloma, neuroblastoma, non_hodgkin lymphoma, ovarian cancer, sarcoma and carcinoma of testis.In other cases, need enter bone marrow acquisition sample of bone marrow or sample and make diagnostic test.These situations include but not limited to the cancer of any kind and the hematopathy that any reason causes.
The anatomical structure that depends on each the selected target district, operator proficiency level and the patient that gather bone and/or corresponding bone marrow, enter bone and corresponding bone marrow with obtain a small amount of biopsy sample or aspirate a large amount of bone marrow can be very difficult, cause wound, danger close also sometimes.Being used to enter the existing apparatus of bone and corresponding bone marrow and method can comprise and wherein be provided with (IO) pin in the bone that can take out the trocar.The handle of different shape and size can be used for the hands pressurization and manually rotates the complete IO pin and the trocar that can take out.The manual IO device of this class usually needs with the outer cortex that pierces through bone very energetically.Apply such power and can cause patient's pain, damage bone and/or IO device sometimes.When the patient of worsening because of disease (cancer) from the softer child of bone structure or bone gathered bone marrow, such power can be brought infringement.
Sometimes, the core sample of using the biopsy needle of standard can't successfully take out bone and/or bone marrow.Therefore, be necessary repeatedly to insert the bone and/or the bone marrow biopsy sample that could obtain satisfaction at different parts.Since increased by the operation of the sharp apparatus that blood stains dye, also higher to medical personnel's danger.Neglectful acupuncture and miss the target area and can make program more seem complicated also increases medical personnel and/or patient's danger.
Traditional bone marrow transplantation technology is carried out conventional bone marrow transplantation needs a plurality of sites of puncture (each patient reaches 20) in order to obtain enough bone marrow.The workload of this program is very big.Traditional biopsy needle and/or aspiration needle generally need be with hands with inserting very energetically.This power can cause out of control or operator's fatigue.When biopsy needle or aspiration needle are in place, generally remove the corresponding trocar, and syringe is connected on the end of biopsy needle or aspiration needle bone marrow to aspirate several cubic centimetres.Extract biopsy needle or aspiration needle then.Can insert new insertion position of about centimeters puncture, position from first usually again.This program can repeat repeatedly.
Summary of the invention
According to instruction of the present disclosure, be provided for aspirating and/or the equipment and the method for biopsy bone marrow.This kind equipment and method also can be used when all kinds of stem cell transplantation program.Various instruction of the present disclosure can be used with the intraosseous device of other type outside the field that vascular access treatment patient is provided and the medical procedure of other type.The example of these programs include but not limited to kyphoplasty art, vertebroplasty, with replacement joint and relevant placement steel wire and screw and other the many orthopedic procedures of fracture internal fixation.Instruction of the present disclosure also can be used for various the intestines and stomach-urology biopsy devices and program.
One aspect of the present invention comprises the bone marrow aspiration system, and this system has the aspiration needle group and can be used for power drill/driver and connector assembly in this aspiration needle group insertion bone and the corresponding bone marrow.This aspiration needle group can comprise the sleeve pipe with single cavity and be slidably disposed on this sleeve pipe cavity interior trocar or stylet.Include but not limited to that all kinds of connections that road strategic point locking connects can be used for the interior trocar of abutment sleeve releasedly.
Another aspect of the present invention comprises bone and/or bone marrow biopsy system, and this system has biopsy needle or biopsy needle group and power drill/driver or manual driver.This power drill/driver and connector assembly can be used for this biopsy needle or biopsy needle group are inserted bone and corresponding bone marrow.This biopsy needle group can comprise the sleeve pipe with single cavity and slidably or releasedly be arranged on the interior trocar of this sleeve pipe cavity.This class pin and pin group can be used for detecting and/or treating various cancers and other disease indication.
Another aspect of the present invention comprises working power driver and connector assembly pin in the bone or the pin group is inserted bone and corresponding bone marrow is obtained bone marrow, and this power drill/driver and connector assembly can be used for rotating pin in this bone or pin group and obtaining the biopsy sample of bone and corresponding bone marrow with optimum speed.Can be provided with single screw in one end of biopsy needle, obtain sample of bone marrow or bone marrow core, thereby improve obtaining of biopsy sample by should single screw screwing in corresponding spongy bone.
One aspect of the present invention comprises power drill/driver is placed in encapsulation bag or the sterilization cover so that this power drill/driver is isolated from the outside.Available flexible, in light weight, the transparent plastic materials of this encapsulation bag is made.This encapsulation bag can comprise and can be used for engaging releasedly with this power drill/driver one end and keep the interface module of fluid barriers with the adjacent part of actuator housing.Intraosseous device can be connected an end of this interface module.The driving shaft that stretches out from this power drill/driver can engage releasedly with the other end of this interface module.
Another aspect of the present invention comprises the biopsy tool kit, and this tool kit has biopsy needle and can be used for taking out the displacer of bone and/or sample of bone marrow or discharging bar from biopsy needle.Also can comprise funnel (being sometimes referred to as " discharge funnel ") in this biopsy tool kit.This funnel can insert an end of biopsy needle for this displacer.According to instruction of the present disclosure, this funnel can comprise that internal diameter dwindles portion.In certain embodiments, the interior section of funnel can be used as " unidirectional adapter ", thereby can allow the tip protector of this funnel as an end that is located at biopsy needle wherein.
Another aspect of the present invention comprises and can be used for connector assembly that the intraosseous device and the part of the driving shaft that stretches out from power drill/driver one end are engaged releasedly.This connector assembly can allow this power drill/driver that this intraosseous device is being inserted position insertion (power insertion) (powerin).This connector assembly also can allow this power drill/driver " fast rotational (spin) " intraosseous device from insertion position taking-up (power is extracted) (power out) time.This feature of the present invention also can be described as " power inserts and power is extracted ".
Equipment of the present invention and method can:
Reduce the physical fitness requirement that the IO device inserts bone and corresponding bone marrow;
Control the IO device during insertion better;
The speed of finishing the IO program improves;
Patient's uncomfortable minimizing;
System and program simplification is understood concerning the operator, is convenient to grasp.
More than general introduction includes only a limited number of examples of various embodiments of the present invention and feature.Other example of embodiment and feature describes in detail hereinafter.
Description of drawings
From below in conjunction with the description of the drawings more complete sum understand various embodiments of the present invention and advantage fully, similar features is represented with similar label in each accompanying drawing, in the accompanying drawing:
Figure 1A is the schematic isometric that is located at aspiration needle group one example of the present invention in the tool kit;
Figure 1B is the schematic isometric that is located at biopsy needle group one example of the present invention in the tool kit;
Fig. 1 C is the schematic isometric of medical procedures trays one example of the present invention, and this medical procedures trays comprises the biopsy needle group and be applicable to other parts that use with power drill/driver in gnotobasis;
Fig. 1 D is for to cut open the profile of getting along 1D-1D line among Fig. 1 C;
Fig. 1 E is the schematic isometric of the medical procedures trays of the present invention of Fig. 1 D, is provided with not sterilise medical apparatus in the encapsulation bag;
Fig. 1 F is another schematic isometric of the medical procedures trays of the present invention of Fig. 1 D, is provided with not sterilise medical apparatus in the encapsulation bag;
Fig. 1 G is another schematic isometric of Fig. 1 C medical procedures trays;
Fig. 1 H is the schematic isometric of Fig. 1 G medical procedures trays after first drop cloth and the expansion of second drop cloth;
Fig. 1 I be according to the present invention Fig. 1 G medical procedures trays in power drill/driver and schematic isometric after connector assembly engages;
Fig. 1 J is that Fig. 1 G medical procedures trays is in the schematic isometric of mentioning after second drop cloth is enclosed in power drill/driver (a not example of sterilise medical apparatus) in the encapsulation bag;
Fig. 2 can (IO) install the sketch map of power drill/driver one example of using according to the present invention in bone;
Fig. 3 A is the schematic isometric of Figure 1A aspiration needle;
Fig. 3 B is the decomposing schematic representation of Fig. 3 A aspiration needle group;
Fig. 3 C is the exploded pictorial axonometric chart of biopsy needle one example of the present invention;
Fig. 3 D is another routine schematic isometric of pin group in the bone of the present invention;
Fig. 3 E is the broken section schematic isometric at the tip of pin group in the bone of Fig. 3 A;
Fig. 3 F is the schematic isometric of an embodiment at intraosseous device of the present invention or telescopic tip;
Fig. 3 G is the schematic isometric of another embodiment at the tip of biopsy needle of the present invention;
Fig. 3 H is the schematic isometric of the another embodiment at the tip of intraosseous device of the present invention or conduit;
Fig. 3 I is the broken section schematic isometric of pin group in the bone of the present invention;
Fig. 3 J is another routine broken section schematic isometric of biopsy needle group of the present invention;
Fig. 4 A is that cross section and part are the exploded pictorial axonometric chart of facade for the part that can be used for threaded insert is fit into the plug broken section in the part of biopsy needle according to the present invention;
Fig. 4 B is the sketch map of an example of the threaded insert in the vertical hole that can be located at biopsy needle according to the present invention;
Fig. 4 C is provided with single screw for the broken section schematic section of biopsy needle one example of the present invention in this biopsy needle one end;
Fig. 4 D is another routine broken section schematic section of biopsy needle of the present invention, is provided with single screw in this biopsy needle one end;
Fig. 4 E is the cross section and the elevational schematic view of the broken section of biopsy needle group of the present invention, and this biopsy needle group comprises the trocar and the close roughly single screw of hollow bushing one end;
Fig. 5 A is the exploded pictorial axonometric chart of power drill/driver of the present invention, connector assembly and intraosseous device;
Fig. 5 B is another exploded pictorial axonometric chart of Fig. 5 A connector assembly and intraosseous device;
Fig. 5 C is another broken section exploded pictorial sectional view of Fig. 5 A power drill/driver, connector assembly and intraosseous device;
Fig. 5 D for before inserting in the connector assembly at an end of driving shaft along the sketch map of looking closely of the connector assembly of 5D-5D line among Fig. 5 C;
Fig. 5 E is the broken section schematic section of Fig. 5 A power drill/driver, connector assembly and intraosseous device;
Broken section schematic section when Fig. 5 F is on the second position that power drill/driver can break away from socket in connector assembly first end for Fig. 5 D connector assembly;
Fig. 5 G illustrates each feature of connector assembly of the present invention and blocking mechanism for to cut open the generalized section of getting along 5G-5G line among Fig. 5 E;
Fig. 5 H illustrates each feature of connector assembly of the present invention and blocking mechanism for to cut open the generalized section of getting along 5H-5H line among Fig. 5 F;
Fig. 5 I is another routine broken section schematic section of connector assembly of the present invention;
Fig. 6 A is the sketch map of connector assembly alternate embodiment of the present invention, and this connector assembly can be used for intraosseous device is engaged releasedly with driving shaft one end that stretches out from power drill/driver;
Fig. 6 B is the broken section generalized section of Fig. 6 A power drill/driver, connector assembly and intraosseous device each several part;
Fig. 7 A is the broken section schematic isometric of power drill/driver of the present invention, encapsulation bag or sterilizing covers and connector assembly;
Fig. 7 B is for being located at another sketch map of the power drill/driver in Fig. 7 A encapsulation bag according to the present invention;
Fig. 8 is the exploded perspective sketch map applicable to intraosseous device of the present invention that uses with power drill/driver of the present invention or manual driver and connector assembly;
Fig. 9 A is the exploded perspective sketch map of biopsy sample displacer of the present invention and corresponding funnel;
Fig. 9 B is biopsy sample displacer of the present invention and another routine schematic perspective view of corresponding funnel;
Fig. 9 C is the generalized section of Fig. 9 B funnel; And
Figure 10 for be positioned at according to the present invention target site and with the cross section and the elevational schematic view of the broken section of the aspiration needle of bone marrow aspiration system connectivity.
The specific embodiment
Be appreciated that each preferred embodiment of the present invention and various advantage with reference to Figure 1A-10, in these accompanying drawings, identical and similar parts are represented with similar label.
" encapsulation bag " speech in this application can comprise that any sterilizing covers (sleeve), sterilization big envelope (envelope), sterile glove, sterilization cover (enclosure) or any other can be used to device that decontaminating apparatus is not engaged with decontaminating apparatus according to the present invention, to carry out the medical procedure of aseptic occasion of requirement or gnotobasis.
In some application scenario, can put into the present invention to the power drill/driver of not sterilizing and encapsulate bag, and engage, in requiring the various medical procedures of aseptic occasion or gnotobasis, to use with the sterilization intraosseous device.These encapsulation bags can be installed on connector assembly of the present invention or any other device, with prevent from not sterilize power drill/driver in this do not sterilize power drill/driver and sterilization bone during (IO) means for engaging with engage this sterilization of after stain IO device.
" driver " speech in this application can comprise the power drill/driver that is applicable to any kind in the selected position of (IO) device insertion patient's blood vessel system in the bone.These power drill/drivers rotate the driving shaft that stretches out from this power drill/driver usually.But various instructions of the present disclosure also can be with the reciprocating power drill/driver of associated drives axle (not illustrating specially) is used.
Various technology are applicable to IO device of the present invention being engaged releasedly with power drill/driver or being connected.For example, the connecting device of the present invention's connector assembly miscellaneous, interface module, joint, socket, connection fittings, needle stand (hub), needle stand assembly, blocking mechanism and/or other type goes for releasedly the IO device being engaged with power drill/driver.
Various connector assembly of the present invention applicable to releasedly will from driver stretch out the axle an end and a termination of intraosseous device close.In certain embodiments, power drill/driver can comprise driving shaft, and its end that is hexagonal cross-section substantially is used for engaging releasedly with the blocking mechanism that is arranged on connector assembly one end.In certain embodiments, connector assembly of the present invention can be described as " without hands " adapter, fast quick-detach or rapid release adapter and/or interface module.
According to the present invention, each blocking mechanism can be arranged to first end and second end near connector assembly.One end of the driving shaft that stretches out from power drill/driver is pushed the annular concave seat that can cause being located on this end of driving shaft second end of connector assembly engages with corresponding interlocking mechanism " engaging " releasedly.Intraosseous device one end is pushed in first end of connector assembly to cause the annular concave seat on this end of intraosseous device to engage releasedly with corresponding blocking mechanism " engaging ".
In certain embodiments, according to the present invention, connector assembly or interface module can engage with encapsulation bag or sterilizing covers.Connector assembly of the present invention and/or needle stand assembly can easily separate relevant power drill/driver with the IO device, so that the IO device can be retained in the patient body, thereby allow marrow aspiration or remove bone and/or the bone marrow biopsy sample.These connector assemblies and/or interface module also can allow power drill/driver from inserting position " fast rotational (spin) " or IO device of being rotatedly connected when extracting the IO device or changing the insertion depth of IO device the target area.Extract or rotate when changing the degree of depth (power is extracted) near the wound that the IO device can improve patient's comfort level greatly and reduce may cause bone and soft tissue the insertion position.
But the working power driver is just inserted IO device of the present invention in selected target district or the target site in 10 seconds or less time.But various instructions of the present disclosure are not limited to use with power drill/driver.Manual driver and spring powered driver also can be used with IO device of the present invention.
The example of manual driver referring to the applying date be January 25 in 2005 day, be called Manual Intraosseous Device coexist the trial in patent application serial number No.11/042,912 (now be United States Patent (USP) _ _ _ _ _).
" fluid " speech in this application can comprise liquid, such as but not limited to blood, water, saline solution, IV solution, slurry, or with the biopsy of bone marrow or suction or with bone marrow or other target site fluid flow any mixture of relevant liquid, particulate matter, dissolved medicament and/or medicine." fluid " speech in this application also can comprise any body fluid and/or contain the liquid of particulate matter, for example can be from the bone marrow and/or the cell of target area suction.
" collection " speech can comprise the biopsy of bone and/or bone marrow and the suction of bone marrow in this application.The biopsy of bone and/or bone marrow (being sometimes referred to as " pin biopsy ") generally can refer to take out more a spot of bone and/or sample of bone marrow to carry out biopsy from the selected target district.Bone marrow aspiration (being sometimes referred to as " bone marrow sampling ") generally can refer to take out relatively large bone marrow from the selected target district.Relatively large bone marrow can be used for diagnosis, transplants and/or research.For example, the relatively large bone marrow of some stem-cell research Technology Need.
" insertion position ", " site of puncture " and " installation position " can represent that intraosseous device can be inserted into or pierce the position on bone in bone and the corresponding bone marrow in this application.Inserting position, site of puncture and installation position is generally covered by skin and soft tissue.
" (IO) device in the bone " speech in this application can include but not limited to can be used for providing any hollow needle, hollow boring bit, perforator assembly, bone puncturing apparatus, conduit, sleeve pipe, the trocar, stylet, interior perforator, outer perforator, IO pin, biopsy needle, aspiration needle, IO pin group, biopsy needle group or the aspiration needle group of the path that enters interior space of bone or inside bone.These IO devices can be at least in part for example 304 rustless steels and other and pin and the corresponding biocompatible material of similar medical treatment device are made with metal alloy.
Can form all kinds of IO devices according to the present invention.The example of these IO devices can include but not limited to biopsy needle, biopsy needle group, aspiration needle and aspiration needle group.But, also can form other IO device miscellaneous according to one or more instructions of the present disclosure.These IO devices can comprise also can not comprise the trocar or stylet.
In some application scenario, the trocar or stylet can insert in corresponding pipe or the telescopic hollow substantially vertical hole or chamber.First end of second needle stand can engage releasedly with second end of first needle stand, so that the trocar or stylet are arranged in vertical hole of sleeve pipe or conduit releasedly.The aspiration needle group 100 or the biopsy needle group 100a that the invention is not restricted among the application to be discussed.
" target area " speech in this application can refer to can therefrom gather the selected part of bone cavity of bone marrow or the selected position in the bone cavity according to instruction of the present disclosure.
Many prior aries of gathering bone and/or bone marrow need puncture more than once bone and corresponding bone marrow are to take out enough bone and/or bone marrow sample.If do not take out biopsy sample satisfactorily in first site of puncture, on same bone, just need a plurality of sites of puncture so.The medical worker need insert some different sites of puncture on the same bone to the IO pin, to obtain to be used to transplant or the capacity bone marrow of stem-cell research.For example, obtain six of capacity bone marrow needs or more insert the position from patient's pelvis.Repeatedly the insertion meeting brings very big misery to patient, and can make some people dare not contribute bone marrow.Repeatedly insert and cause fatigue also can for the medical worker who uses manual IO device to carry out these programs.
Bone marrow transplantation program and various search procedure for example stem-cell research need relatively large bone and/or bone marrow usually.The bone cavity of hipbone is generally bigger, therefore is commonly used for the target area of the bone marrow of gathering any other program that is used for transplanting program, stem-cell research program or the relatively large bone marrow of needs.
In some occasion, IO pin or other IO device can be formed with first end of be used to puncture bone and/or corresponding bone marrow.Joint or needle stand can be connected to second end of this IO pin or other IO device.These joints or needle stand can be used for releasedly this IO pin or IO device being engaged with power drill/driver, manual driver and/or connector assembly.
IO pin group of the present invention and other IO device can comprise an IO device, for example sleeve pipe, conduit or outer perforator and the 2nd IO device, for example stylet, the trocar or interior perforator.Can be formed with various facets near first end of an IO device and first end of the 2nd IO device.The facet of the facet of the one IO device and the 2nd IO device can be worked in coordination, with puncture bone and/or corresponding bone marrow.
First joint or first needle stand can be used for releasedly with an IO pin or IO device and the 2nd IO pin or IO means for engaging.For example, IO pin group can comprise first joint or first needle stand, and hollow substantially sleeve pipe, conduit or outer perforator connect thereon and extend from first end of first needle stand.Second end of first needle stand can be used for closing with first termination of second joint or second needle stand releasedly.Stylet, the trocar or interior perforator also can be connected to first end of second needle stand and extend from first end of second needle stand.Second end of first needle stand can comprise opening, and its big I allows stylet, the trocar or interior perforator to pass the cavity of this opening and sleeve pipe, conduit or outer perforator.
Second end of second needle stand can be used for closing with first termination of connector assembly of the present invention releasedly.One end of the axle that stretches out from power drill/driver or manual driver can engage releasedly with second end of this connector assembly.
About other details of power drill/driver, joint, needle stand and IO device can referring to the applying date for _ _ _ _, name is called the patent application serial number No.____ in the trial that coexists of Powered Driver Intraosseous Device and MethodTo Access Bone Marrow, this application requires the preference of the temporary patent application that the applying date is on April 4th, 2007, title is identical.
Can be with reference to power drill/driver 200, connector assembly 250,250a, 250b and 250c, needle stand assembly 130,130a, 130b and 130c, IO pin group 100,100a and 100b, biopsy needle 100c and/or encapsulation bag 170 illustrate each feature of the present invention.But, the invention is not restricted to these power drill/drivers, connector assembly, needle stand assembly, 1O pin group, biopsy needle and/or encapsulation bag.Can form intraosseous device miscellaneous, needle stand assembly, connector assembly and/or the encapsulation bag of various sizes and/or structure according to the present invention.
Figure 1A-1J illustrates medical procedures trays that the one or more intraosseous devices of the present invention and/or other parts can be housed and/or some examples of tool kit.For example, the 20a of medical procedures trays shown in Figure 1A can comprise pin group or aspiration needle group 100 in the bone of the present invention.The 20b of medical procedures trays shown in Figure 1B can comprise pin group or biopsy needle group 100b, displacer 90, funnel 80 and/or encapsulation bag or sterilizing covers 170 in the bone.Medical procedures trays 20c shown in Fig. 1 C-1I also can comprise the various IO devices of the present invention and other parts, and these parts include but not limited to biopsy needle group 100b, connector assembly 250, encapsulation bag 170, displacer 90 and/or funnel 80a.
Medical procedures trays formed according to the present invention and/or tool kit can be various parts for example connector assembly, funnel and/or tip protector provide support or the basis, just can carry out various functions to allow operator or user to need not to hold or operate each parts.For example, medical procedures trays 20c shown in Figure 1 can make connector assembly 250 location one end of power drill/driver can insert (pushing) to become with second end 252 of connector assembly 250 and engage releasedly with supporting to.Then, operator or user need not directly to hold or be operatively connected device assembly 250 and take out connector assembly 250 with regard to the usable power driver from medical procedures trays 20c.
Medical procedures trays formed according to the present invention and tool kit can have structure miscellaneous and/or size.In some occasion, the tool kit that intraosseous device is housed according to the present invention can always be about 4.5 inches, and is wide about 3 inches, dark about 2 inches.Various heat-sealing technology are applicable to removable lid (not illustrating specially) is contained on medical procedures trays of the present invention or the tool kit.
Medical procedures trays 20a, 20b and/or 20c also can be equipped with various other parts, include but not limited to the tip protector 64a shown in the one or more tip protectors 64 shown in Figure 1A and the 1B or Fig. 1 C, 1E and the 1F.Tip protector 64 and 64a can comprise stiff foam material or the argillaceous material of being located in it 66.Intraosseous device for example aspiration needle group and biopsy needle group generally has corresponding tip and/or the facet that can be used for skin puncture, soft tissue and bone.The tip of these intraosseous devices and/or facet can insert in stiff foam material or the argillaceous material 66 after using corresponding intraosseous device to finish medical procedure.
In some occasion, medical procedures trays 20a can be described as " bone marrow aspiration pallet ", " suction procedures trays " or " bone marrow aspiration tool kit ".In some occasion, medical procedures trays 20b and 20c can be described as " bone and/or bone marrow biopsy procedures trays " or " biopsy procedure pallet " or " bone marrow biopsy tool kit " sometimes.
Medical procedures trays 20a, 20b and/or 20c can make with the various polymeric materials that are suitable for aseptic packaging and store the various parts in each medical procedures trays.In some occasion, when the assembling of medical procedures trays 20a, 20b and 20c and packing, can use the ethylene oxide sterilizing technology.But, suitably also can use other sterilizing program.
As the part of corresponding sterilization and packaging process, can on each medical procedures trays 20a, 20b and 20c, close the lid (not illustrating specially).These can take off before covering various parts in using each medical procedures trays.
Medical procedures trays or suction pallet 20a (seeing Figure 1A) can comprise that size is suitable for the elongate groove 22 of corresponding intraosseous device such as but not limited to aspiration needle group 100.The size of groove 22 and configuration can be selected, with the length overall of the sleeve pipe 110a that adapts to needle stand assembly 130 and stretch out from needle stand assembly 130.The big I of one end of groove 22 is designed to adapt to the size and the configuration of needle stand assembly 130.Also can provide the opening or the finger groove 24 of expansion, so that in groove 22, insert and take out aspiration needle group 100.Each details relevant with aspiration needle group 100 will be discussed in conjunction with Fig. 3 A hereinafter.
Tip protector 64 can be arranged in the bearing 26 of medical procedures trays 20a.Also can be formed with pair of finger groove 28 among the pallet 20a, so that in bearing 26a, insert and take out tip protector 64.Also can be formed with bearing 26b among the pallet 20a with respective finger groove 28.Other tip protector or other parts can be placed in the bearing 26b.Size/configuration of groove 22 and bearing 26a, 26b can change according to the needs that will be placed on wherein each parts.
Medical procedures trays or biopsy pallet 20b (seeing Figure 1B) can comprise elongate groove 30 and 32.The size of elongate groove 30 and configuration may be selected to and be suitable for placing therein displacer 90.The size of elongate groove 32 and configuration may be selected to and be suitable for placing therein intraosseous device or biopsy needle group 100b.
The size of elongate groove 30 1 ends and configuration may be selected to second end 92 of being located at ejector bar 94 on the size and the configuration of handle 96 suitable mutually.Pair of finger groove 34 can constitute the part of elongate groove 30, to allow to install and take out displacer 90.One end of elongate groove 32 can be suitable mutually with corresponding configuration and the size of the needle stand assembly 130a of biopsy needle group 100b.Pair of finger groove 36 also can be used as the part of elongate groove 32, to be suitable for inserting and taking out biopsy needle group 100b in elongate groove 32.
Pallet 20b also can comprise the bearing 38 adjacent with elongate groove 30.The size of bearing 38 and configuration can be suitable for putting into releasedly therein funnel 80.Pallet 20b also can comprise compartment or bearing 40, and its size is suitable for placing the encapsulation bag 170 that is connected with connector assembly 250.Can be placed with one or more samples or shuttle or cup (not illustrating specially) among the biopsy pallet 20b.Biopsy sample or shuttle can comprise that big I is suitable for receiving from biopsy needle group 100b the chamber of biopsy sample.Funnel bearing 38 can be formed among the biopsy procedure pallet 20b adjacent with displacer 90, is easy to obtain with assurance funnel 80, thereby helps to take out biopsy sample from biopsy needle group 100b.
Medical procedures trays shown in Fig. 1 C-1I or biopsy pallet 20c represent another example of medical procedures trays formed according to the present invention.Biopsy procedure pallet 20c can comprise intraosseous device or the biopsy needle group 100b and the displacer 90 that is placed in the elongate groove 44 that is placed on releasedly in the elongate groove 42.Elongate groove 42 and 44 respective end can be adjacent one another are, so that can easier formation finger groove 46a, 46b and 46c.Biopsy procedure pallet 20c also comprises a pair of tip protector 64a that is located in the corresponding bearing 48.Each bearing 48 comprises pair of finger groove 50.
One of advantage of the present invention comprises and can releasedly an end of power drill/driver and a termination of connector assembly be closed; End with biopsy needle engages with the other end of this connector assembly releasedly; The other end of this biopsy needle is inserted the selected target district; " power is extracted " biopsy needle under guaranteeing to have in the biopsy needle situation of biopsy sample reliably; And the other end of biopsy needle inserted funnel to protect most advanced and sophisticated and to take out biopsy sample.The direct contact of operator and biopsy needle can be only limited in the corresponding end that an end of biopsy needle is pushed connector assembly.
In medical procedures trays 20c, also can be formed with a pair of bearing or anchor clamps (not illustrating specially) with the bearing adjacent that is used for connector assembly 250.These anchor clamps can be designed to hold first end 181 and second end 182 of the flexible strut 180 on second opening 172 of being located at encapsulation bag 170.Connector assembly 250 also can be installed in the bearing 58 of biopsy procedure pallet 20c, its first end 251 down, second end 252 is up.
Fig. 1 E and 1F illustrate according to the present invention and are used for power drill/driver is placed an interior program of encapsulation bag.Encapsulation bag 170 can be made with substantial flexibility, fluid-tight material, also can use the routine disinfection technology that it is carried out disinfection.When bone marrow biopsy program or bone marrow aspiration program, encapsulation bag 170 can be used for preventing that the disinfectant power drill/driver does not pollute disinfectant intraosseous device and/or site of puncture especially.Encapsulation bag 170 can be operated, and forms fluid barriers with the adjacent part with housing unit 270.Simultaneously, connector assembly 250 allows power drill/driver to rotate the intraosseous device that engages releasedly with connector assembly 250 first ends 251 and does not damage encapsulation bag 170.
Along encapsulation bag or overlap one side of 170 and can be formed with first opening 171.Relative another side along encapsulation bag 170 can be formed with second opening 172.The size of second opening 172 and configuration may be selected to and be suitable for inserting and take out not sterilise medical apparatus of power drill/driver or other from this second opening 172.
In some occasion, power drill/driver 200 can directly place the encapsulation bag, and engages with connector assembly 250.In other occasions, be associated with from medical procedures trays, taking out connector assembly 250, the power drill/driver of not sterilizing can insert in the encapsulation bag 170.
In some occasion, can take off over cap (not illustrating specially) from medical procedures trays 20c.Then, can pass second opening 172 of encapsulation bag 170 from the end 224 that the driving shaft 222 of power drill/driver 200 extends, and engage releasedly with second end 252 of connector assembly 250.
Then, take out first end 181 and second end 182 of flexible strut 180 in corresponding anchor clamps that can be from medical procedures trays 20c or the bearing, with hands second opening 172 is upwards mentioned with respect to power drill/driver 200 allowing.See Fig. 1 E.Encapsulation bag 170 can continue to be raised to complete expanded position, and makes power drill/driver 200 place the encapsulation bag.See Fig. 1 F.Then, flap 174 can be covered on second opening 172.Then, can from the bearing 58 of medical procedures trays 20c, take out the encapsulation bag 170 and the connector assembly 250 of wherein dynamic driver 200.
Fig. 1 G-1J illustrates another program of the present invention, the power drill/driver of not sterilizing is put into the encapsulation bag, connector assembly or interface module are enclosed in this encapsulation bag from this encapsulation bag extension and this power drill/driver of not sterilizing, and make this connector assembly to engage with the sterilization intraosseous device.Also available identical program with other not sterilise medical apparatus engage with sterilise medical apparatus.
In some occasion, can be placed on medical procedures trays 20c among the second pallet 20d, be provided with first drop cloth 51 between them.See Fig. 1 G and 1J.Then, can be opening being arranged or 54 second drop cloth 52 of windowing places on the medical procedures trays 20c, opening or window and 54 align substantially with second opening 172 of encapsulation bag 170 and second end 252 of connector assembly 250.Second drop cloth 52 also can cover first drop cloth 51 from outward extending part between medical procedures trays 20c and second medical procedures trays (not illustrating specially).
In some occasion, can the engaging releasedly with the part adjacent of encapsulation bag 170 of second drop cloth 52 with second opening 172 with the 54 adjacent parts of windowing.See Fig. 1 J.Various low-intensity jointing materials on sale come to provide releasable between second opening 172 near window 54 part and encapsulation bag 170 of second drop cloth 52 and engage on the available markets.
Then, for example shown in Fig. 1 G, can fold first drop cloth 51 and second drop cloth 52, to cover the thing in the medical procedures trays 20c.Between the appropriate section of first drop cloth 51, can see the part of second drop cloth 52 among Fig. 1 G.
Then, can cover the exposed portions serve of these two medical procedures trays and drop cloth 51 and 52 to over cap (not illustrating specially).Then, can be to medical procedures trays (the not illustrating specially) sterilization of this combination.According to the present invention, advantage of this disinfectant includes but not limited to provide disinfectant encapsulation bag, and it can be used to sterilise medical apparatus is not engaged with sterilise medical apparatus.
Then, first drop cloth 51 and second drop cloth 52 be can shown in Fig. 1 H, launch, thereby 54 second opening 172 of encapsulation bag 170 and second end 252 of connector assembly 250 exposed by windowing on second drop cloth 52.The people's (not illustrating specially) that do not sterilize can pass the power drill/driver 200 of not sterilizing opening or window 54 then, and the end 224 of the driving shaft 222 that stretches out of the power drill/driver 200 of will never sterilizing engages releasedly with second end 252 of connector assembly 250.Then, the people that do not sterilize can be lifted to position shown in Fig. 1 J to second drop cloth 52, and this moment, power drill/driver 200 was positioned at encapsulation bag 170.The people that do not sterilize can continue to mention second drop cloth 52, thus engaging between that discharge second drop cloth 52 and the part adjacent window 54 adjacent parts and encapsulation bag 170 with second opening 172.
The general procedure relevant with using medical procedures trays of the present invention or tool kit can comprise the following steps.Medical procedures trays 20d is placed and will carry out on the precalculated position of related medical program.For example, can place medical procedures trays 20d near the operating-table the table or utility cart, wherein, bone marrow aspiration program or bone marrow biopsy program can be carried out on this operating-table.
The sterilization people can take off corresponding lid from medical procedures trays 20d, to expose folding drop cloth 51 and 52.Then, the sterilization deployable drop cloth 51 of people and 52 is shown in Fig. 1 H.Then, the people that do not sterilize can pick up the power drill/driver 200 of not sterilizing, and power drill/driver 200 is passed window 54 on second drop cloth 52, shown in Fig. 1 H.The end 224 of the driving shaft 222 of power drill/driver 200 can be " snapped " in connector assembly 250 second ends 252.The people that do not sterilize can mention second drop cloth 52 then shown in Fig. 1 J, thereby causes encapsulation bag 170 to be lifted on the power drill/driver 200.The people that do not sterilize can take second drop cloth 52 then away.
The sterilization people can cover flap 174 second end 172 of encapsulation bag 170 then.Then, this sterilization people can catch the handle 214 of power drill/driver 200 by encapsulation bag 170, and the bearing 58 of the power drill/driver 200 that is connected with connector assembly 250 on it from tool kit 20c mentioned.Then, this sterilization people can take out for example biopsy needle group 100b of intraosseous device from medical procedure tool kit 20c, and second end 102 of biopsy needle group 100b is inserted in first end 251 of connector assembly 250.When second end 102 of biopsy needle group 100b (or any other intraosseous device of the present invention) is locked in connector assembly 250 first ends 251 releasedly, can feel " engaging ".When second end 102 with after first end 251 of connector assembly 250 engages releasedly, can take off pin protective cap (not illustrating specially) from biopsy needle 100b first end 101.
The sterilization people can hold power drill/driver 200 in the encapsulation bag 170 together with connector assembly 250 and the biopsy needle group 100b that stretches out from connector assembly 250 with one, confirms the insertion position with another hands simultaneously.Power drill/driver 200 can place and insert on the position, so that biopsy needle group 100b first end 101 is pierced through skin to the bone direction.When touching bone, but operator's squeeze buttons or trigger 246 and the handle 214 of power drill/driver 200 applied metastable soft pressure.After piercing through bone cortex, the operator can decontrol trigger 246, with the further insertion of first end 101 that stops biopsy needle group 100b.
Then, can be to the effect of first shell section 280, to throw off engaging of biopsy needle group 100b second end 102 and connector assembly 250.Then, can rotate counterclockwise the second needle stand 150a, so that the second needle stand 150a and corresponding stylet 120 are thrown off from the first needle stand 140a.See Fig. 3 B.Then, can extract stylet 120 out, and from biopsy needle or sleeve pipe 110b, take away.Then, can insert stylet 102 first ends 121 among the tip protector 64a.After suitable biopsy procedure was finished, the second needle stand 150a can engage once more with the first needle stand 140a.Then, connector assembly 250 first ends 251 can engage once more with biopsy needle group 100b second end 102, to rotate or fast rotational biopsy needle group 100b, extract out from inserting the position simultaneously.After opening from the insertion section displacement, biopsy needle group 100b second end 102 can be disengaged with connector assembly 250.Then, can insert biopsy needle group 100b first end 101 among the tip protector 64a.
After second drop cloth 52 took away from second opening 172, sterilization people (not illustrating specially) can close flap 174, so that the power drill/driver of not sterilizing is enclosed in wherein.This sterilization people can take out encapsulation bag 170, power drill/driver 200 and connector assembly 250 from bearing 58 then.The sterilization people can engage connector assembly 250 first ends 251 with a end of sterilization intraosseous device in being located at medical procedures trays 20c of the present invention then releasedly.After using this intraosseous device to finish bone marrow aspiration program, bone and/or bone marrow biopsy program and/or other medical procedure, the tip of this intraosseous device or tip can insert in the material 66 among the tip protector 64a, further to dispose according to suitable program.
Drop cloth miscellaneous can be suitable for using with medical procedures trays of the present invention or tool kit.One example of the drop cloth relevant with medical procedure is seen United States Patent (USP) 4,553,539.But first drop cloth 51 and/or second drop cloth 52 can be made from a variety of materials, and can be various configurations and/or size.
Fig. 1 E, 1F, 1I, 2 and 5A shown in power drill/driver 200a shown in power drill/driver 200 and Fig. 7 A and the 7B applicable to intraosseous device of the present invention is inserted in bone and the corresponding bone marrow.Power drill/driver 200 is similar substantially with 200a, and just the end 224 of the driving shaft 222 that stretches out from housing 210 first ends 211 is different with 224a.For example see Fig. 2 and 7A.Therefore only describe power drill/driver 200 below in detail.
Power drill/driver 200 can comprise housing 210, and the overall configuration of this housing 210 is similar to the pocket pistol that is partly limited by handle 214.Each parts relevant with power drill/driver 200 can be positioned at the housing 210 that comprises handle 214.For example, can be provided with for example set of cells 216 of power supply in the handle 214.Set of cells 216 can be various structures and size.
Comprise handle 214 housing 210 can with the polymeric material firmer, that bearing capacity is big for example the material that is fit to of Merlon or other make.In some occasion, housing 210 can be made of halves (not illustrating specially), and this halves can be tightly connected together with fluid-tight, is located at each parts of the intravital power drill/driver 200 of shell with protection.
In the part adjacent that motor 218 and gear drive 220 can be arranged on housing 210 with handle 214.Motor 218 can be aligned with each other basically with gear drive 220.Motor 218 can engage rotationally with an end of gear drive 220.Driving shaft 222 can engage with the other end opposite with motor 218 of gear drive 220 and stretch out from this end rotationally.In some occasion, motor 218 and gear drive 220 can all be substantial cylindrical.
Can obtain to be suitable for the motor and the gear drive that use with power drill/driver 200 from each distributors.These motors and gear drive can " complete " be provided with, and an end of each motor firmly is connected with an abutting end of respective gears actuating device.The driving shaft of various sizes and/or structure can stretch out from an end opposite with motor of gear drive.This gear drive can be described as " reduction gearing " or " planetary gear " sometimes.The size of housing 210 and/or structure can change, to adapt with corresponding motor and gear drive.
The far-end of housing 210 or first end 211 can comprise opening (not illustrating specially), and the part of driving shaft 222 is stretched out from this opening.In some occasion, the part or the end 224 of the driving shaft 222 that extends from first end 211 of housing 210 can be roughly hexagonal cross-section, and each surface 226 is arranged on it.The socket of being located in connector assembly 250 second ends 252 263 can have the roughly hexagonal cross-section that matches.See Fig. 5 E.
Can be roughly parallel to each other and extend abreast with longitudinal axis or pivot center (not illustrating specially) corresponding to driving shaft 222 in each surface 226.Also can be formed with one or more taper surfaces 228 on the end 224, power drill/driver 200 be engaged releasedly with connector assembly 250 helping.See Fig. 5 E and 5G.The end of the driving shaft that stretches out from power drill/driver can be various configurations.For example see Fig. 6 A and 6B.
Driving shaft with required size and structure can stretch out from one side opposite with motor of gear drive.This driving shaft can be used as the part of every cover motor and gear drive.The size of respective housings and/or structure can change according to instruction of the present disclosure, to adapt to various motors, gear drive and/or driving shaft.For example, the power drill/driver that uses with aspiration needle and/or biopsy needle can comprise the gear drive of large-size, satisfying than the big retarding ratio as 60: 1～80: 1, thereby causes the RPM of driving shaft lower.Be used for when the emergency medical service program, providing the power drill/driver of bone inner gateway can be, and can comprise gear drive, for example be 10: 1～30: 1, thereby cause the RPM of driving shaft higher with less speed reducing ratio in high rotational speed work.In some occasion, the size differences of gear drive causes the internal diameter of respective housings to increase about 2～3mm, be fit to corresponding to the power drill/driver that is used for inserting biopsy needle and/or aspiration needle than the open-bull gear drive device.
There is the connector assembly of respective openings or socket to engage releasedly with end 224 of stretching out or the end 224a that stretches out from power drill/driver 200a first end 211 from power drill/driver 200 first ends 211.For example, as Fig. 1 E, 1F shown in 5C and the 5D, can engage with the socket 264 near connector assembly 250 second ends 252 releasedly from the end 224 that housing 210 first ends 211 stretch out.
In some occasion, can be provided with thrust bearing 241 between the adjacent part of housing 210 first ends or far-end 211 and gear drive 220.Can be provided with thrust bearing 242 between the adjacent part of housing 210 second ends or near-end 212 and motor 218.Thrust bearing 241 and 242 can limit the lengthwise movement in housing 210 each relevant portion of motor 218, gear drive 220 and driving shaft 222.
In housing 210, also can be provided with trigger assembly 244 near handle 214.Trigger assembly 244 can comprise trigger or contact switch 246.Alternately press or unclamp trigger 246 and just can switch on or off motor 218.Also can be provided with circuit board 247 in the housing 210.Circuit board 247 can be electrically connected with trigger assembly 244, motor 218, power supply 216 and display lamp 248.
In some occasion, display lamp 248 can be light emitting diode (LED) or more common miniature bulb.In some occasion, display lamp 248 can be lighted when 90% electric reserves of set of cells 216 run out.
The structure of intraosseous device of the present invention is different and different with visual its each intraosseous device application of size.For example, the length of biopsy needle of the present invention can be from about 5mm to 30mm.But, also can form biopsy needle with other length according to the present invention.The length of aspiration needle of the present invention is about 25mm, 60mm and 90mm.In some occasion, length is that 90mm or longer aspiration needle also can comprise one or more side mouths.For example see Fig. 3 A.The external diameter of (1O) device and vertical hole or chamber can be roughly corresponding with No. 18-No. 10 pins in the bone of the present invention.The structure of each IO device and size are decided by the size and the corresponding bone marrow desired depth of puncture of corresponding bone.
Power drill/driver and connector assembly and aspiration needle group being united use according to the present invention can enter crista iliaca or other rapidly and insert the position and answer bone marrow with extract phase.Bone marrow aspiration of the present invention system can insert desired depth in the spongy bone to aspiration needle in second at 10-15.According to the present invention, this ability can be used for obtaining bone and/or sample of bone marrow according to inserting biopsy needle with the optimum speed that obtains reliable biopsy sample.
Bone marrow aspiration of the present invention system can be provided for that aspiration needle inserted spongy bone and extract the power drill/driver and the connector assembly of bone marrow out.The aspiration needle group can be taken out the trocar or stylet after inserting and being used to extract the desired depth of bone marrow out in the bone from corresponding pipe or telescopic chamber.Needle stand assembly of the present invention can be connected on second end of this pin group, so that relatively easily and promptly take out the trocar or stylet from the chamber of sleeve pipe or conduit.Then, the road strategic point locked joints that is connected on sleeve pipe or the supravasal needle stand can be connected with the bone marrow aspiration system.See Figure 10.In some occasion, needle stand and needle stand assembly can be made with medical Merlon.
After suction aequum bone marrow or required sample of bone marrow had been finished in first target area, the trocar or stylet can insert in outer perforator or the telescopic chamber again.First end that is connected in the needle stand on the trocar or the stylet can engage once more with second end that is connected in sleeve pipe or supravasal needle stand.Then, available power drill/driver of the present invention and connector assembly insert in the spongy bone second desired depth to the aspiration needle group obtaining another sample of bone marrow, or this aspiration needle group of available this power drill/driver " power is extracted ".Can provide most advanced and sophisticated security protection ability for stylet and/or sleeve pipe as the part of described suction system.
In the embodiment of IO pin group 100 and 100a representative, first end, the 121 puncture bone and the corresponding bone marrow of the first end 111a of available sleeve pipe 110a and stylet 120.Each feature of sleeve pipe 110a first end 111a and stylet 120 first ends 121 illustrates in greater detail in Fig. 3 D and 3F.First end 101 of IO pin group 100 and 100a can be roughly corresponding with sleeve pipe 110a first end 111a and stylet 120 first ends 121.
Can have a plurality of labellings 104 on the exterior section of sleeve pipe 110a.Labelling 104 can be described as " telltale mark " or " degree of depth indication " sometimes.Labelling 104 can be used for representing aspiration needle group 100 or the paracentesis depth of 100a in bone and corresponding bone marrow.In some occasion, sleeve pipe 110a can be about 60mm, and nominal outside diameter can be about 0.017 inch, roughly is equivalent to pin No. 16.Sleeve pipe 110a can make with rustless steel or other suitable biocompatible material.Telltale mark 104 can be apart from one another by about 1cm on sleeve pipe 110a exterior section.In some occasion, can on sleeve pipe 110a exterior section, be formed with one or more and first end 111a side mouth 106 separately.
Needle stand assembly 130 shown in Fig. 3 A can be used for stylet 120 is arranged in the vertical hole or chamber 118 of sleeve pipe 110a releasedly.See Fig. 3 E.Needle stand assembly 130 can comprise first needle stand 140 and second needle stand 150.Second end opposite of sleeve pipe 110a with the first end 111a can with the second end firm engagement of sleeve pipe 110a.Second end opposite of stylet 120 with first end 121 can with the first end firm engagement of needle stand 150.
As shown in Figure 3A, sleeve pipe 110a can longitudinally stretch out from needle stand 140 first ends 141.Stylet 120 also can stretch out (not illustrating specially) from needle stand 150 first ends.Needle stand 140 second ends can comprise the standard Luer locked joints that can engage releasedly with the corresponding road strategic point locked joints in being located at second needle stand, 150 first ends.Being threaded between dotted line shown in Fig. 3 A 134 expression first needle stand 140 second ends and second needle stand, 150 first ends.The details of the example of road strategic point locking connection and/or joint are seen Fig. 3 B, 3C, 5E, 5F, 5I and 10.Be located at road strategic point locked joints on needle stand 140 second ends and can be used for being connected joint releasedly with the intravenous (IV) of standard syringes type joint and/or standard.
Various sockets can be suitable for being located in needle stand 150 second ends 152, needle stand assembly 130 are engaged releasedly with power drill/driver being used for.For example, the socket with the general conical corresponding with the taper configurations of driving shaft one end that stretches out from power drill/driver structure can engage releasedly with second end 152 of needle stand 150.Power drill/driver 200a shown in Fig. 6 A and the 6B can represent an a kind of like this example of power drill/driver, and the driving shaft that stretches out from housing of this power drill/driver has tapered portion, thereby can be used for engaging releasedly with the socket with corresponding general conical structure.In some occasion, be located at the Magnet (not illustrating specially) from the diminished shaft end that power drill/driver stretches out and be located at the metal dish in the respective socket the intraosseous device by employing, this class power drill/driver can be fastened on this intraosseous device.This class power drill/driver also can use with being used to obtain the intraosseous device that urgent blood vessel enters (EVA).
Among other embodiment described in detail below, can operate second end of needle stand assembly, to be placed in the socket that is formed in the connector assembly of the present invention.A feature of the present invention can comprise formation needle stand assembly, and this needle stand assembly can be bonded in first socket that is located in connector assembly first end releasedly.For example see shown in Fig. 5 E near the socket 263 that extends core 260 first ends 261.The structure of socket 263 and size may be selected to when the IO device being inserted in bone and the corresponding bone marrow (rotation) and prevent that needle stand 150a from rotating with respect to needle stand 140a.This power drill/driver can engage releasedly with second socket in being located at this connector assembly second end.For example see shown in Fig. 5 E near the socket 264 that extends core 260 second ends 262.
In intraosseous device shown in Fig. 3 B or aspiration needle group 100a, needle stand 150a first end 151 is spaced apart with needle stand 140a second end 142.As shown in the figure, the part of stretching out from needle stand 150a first end 151 of stylet 120 is slidably disposed in the chamber or vertical hole 118 of sleeve pipe 110a.
The 130a of needle stand assembly shown in Fig. 3 B can comprise first end 131, and this first end 131 can be roughly corresponding with needle stand 140a first end 141.Needle stand assembly 130a also can comprise second end 132, and this second end 132 can be roughly corresponding with needle stand 150a second end 152 and needle stand assembly 130a second end 102.See Fig. 3 B.Sleeve pipe 110a can be connected on needle stand 140a first end 141 and from this first end 141 and stretch out.
Needle stand 140a second end 142 can comprise that the strategic point locking of common road connects or half of joint, its can be used for be located at the second needle stand 150a, first end 151 in the road strategic point lock and be connected or the appropriate section of joint engages releasedly.In Fig. 3 B and 3C illustrated embodiment, needle stand assembly 130a first end 131 can be corresponding with the first needle stand 140a, first end 141.The second needle stand 150a, second end 152 can be corresponding with needle stand assembly 130a second end 132 and aspiration needle group 100a second end 102.
At least a portion of needle stand assembly 130a can have roughly hexagonal cross-section, and it can be received within the socket 264 of the roughly hexagonal cross-section that is provided with near connector assembly 250 first ends 251.See Fig. 5 E.In certain embodiments, the part adjacent with reduced diameter portion 143 of the first needle stand 140a can have roughly hexagonal cross section.See Fig. 3 B and 3C.Various cross sections except hexagon are applicable to power drill/driver is engaged with the other end of connector assembly releasedly with an end of connector assembly and with intraosseous device.
The aspiration needle group can comprise the trocar, stylet or the interior perforator with respective sleeve, conduit or the combination of outer perforator usually.But biopsy needle of the present invention can comprise also can not comprise the trocar, stylet or interior perforator.For example, biopsy needle 100c shown in Fig. 3 C is connected on needle stand 140a first end.Stylet or interior perforator are not connected on needle stand 150a first end 151.
In the embodiment by biopsy needle 100c representative, needle stand 140a can be used for biopsy needle 100c is bonded in the socket that forms in the connector assembly of the present invention releasedly.Can connect needle stand 150a, with the end 141 of sealing needle stand 140a.But in many occasions, the needle stand 140a with needle stand 150a can not be connected with an end of connector assembly of the present invention.Biopsy needle 100c can be used for obtaining the biopsy sample of bone and corresponding bone marrow.In biopsy needle 100c, place the trocar and when puncturing bone, can cause sizable infringement the bone sample with the combination tip of the trocar and biopsy needle 100c.
Needle stand 140a can comprise second end 142 that is formed with opening 144.Passage 146 can extend to first end 141 from second end 142 of needle stand 140a.See Fig. 5 E, 5F and 5I.Passage 146 can be used for being communicated with chamber 118 fluids of sleeve pipe 100a.Needle stand 140 second ends 142 can comprise that the strategic point locking of common road connects or the various features of joint, comprise screw thread 148.Can be formed with corresponding screw thread 158 in needle stand 150a first end 151.For example see Fig. 5 E, 5F and 5I.The structure of the socket 263 in connector assembly 250 first ends 151 and size may be selected to the relative motion that prevents between needle stand 140a and the needle stand 150a when the IO device being inserted (rotation) in bone and the corresponding bone marrow.If this relative motion takes place, being connected between the screw thread 148 and 158 can be thrown off.
In some occasion, needle stand 140a and needle stand 150a can adopt injection molding technology and form.In certain embodiments, needle stand 140a can comprise the reduced diameter portion 143 that is located between first end 141 and second end 142.For example see Fig. 3 B, 3C and 5C.In a similar fashion, a plurality of spaces or the otch 153 that can in needle stand 150a, be formed with contiguous second end 152 and extend to the direction of first end 151 from second end 152.For example see Fig. 3 B, 3C and 5A.The structure of reduced diameter portion 143 and/or otch 153 and size can change, so that corresponding injection molding technology optimization provides required structure, size and the strength of materials simultaneously, play a role according to the present invention to allow respective needle holder assembly 130a.
Fig. 3 D and 3E illustrate a facet and a most advanced and sophisticated example, and they can be formed near sleeve pipe and the respective sleeve needle end part according to the present invention.By sleeve pipe or outside among the embodiment of perforator 110a and the trocar or interior perforator 120a representative, the tip 123 of stylet 120 can be near the tip 113 of sleeve pipe 110a.In some occasion, simultaneously the grinding trocar 120 first ends 121 and the sleeve pipe 110a first end 111a are to form adjacent facet 114 and 124.Shown in Fig. 3 D and 3E, grinding end 111a and 121 can form single cutter unit simultaneously, to form cutting edge 124e and the 114e that roughly matches.The facet of other type formed according to the present invention illustrates hereinafter.
The trocar 120 first ends 121 can pass the opening 144 in needle stand 140a second end 142.See Fig. 3 B.The needle stand 150a that is located on the trocar 120 second ends can engage releasedly with sleeve pipe 110a second end of being represented by needle stand 140a.See Fig. 3 B.
Because existing biopsy needle can't obtain satisfied bone and/or sample of bone marrow sometimes, so oncologist possibly can't successfully obtain suitable bone and/or sample of bone marrow with other medical personnel.When obtaining sample, sample is damaged sometimes or is polluted.Intraosseous device of the present invention can significantly reduce or eliminate the problem that runs into when obtaining suitable bone and/or sample of bone marrow.Various instruction of the present disclosure can have increased access to the probability of satisfied spongy bone and corresponding bone marrow biopsy sample greatly.
People's bone generally has hard outer layer or the osseous tissue layer that is called " cortical bone ".Spongy bone (being also referred to as dendritic bone or spongy bone) generally is filled in the inner chamber relevant with cortical bone.Spongy bone is that density and intensity are general lower but another kind of osseous tissue that surface area is big.Spongy bone generally comprises spicule or bone trabecula, and they form the network structure in the gap that is full of connective tissue or bone marrow.The spongy bone exterior section generally comprises the red bone marrow that generates the hemocyte composition.The most of tremulous pulsies and the vein of bone are arranged in corresponding spongy bone.
One of advantage of the present invention comprises various intraosseous devices, and intraosseous device includes but not limited to biopsy needle group and biopsy needle, and they are used for reliably obtaining the biopsy sample of cortical bone and/or spongy bone and the corresponding biopsy sample of not serious infringement.For example, form a plurality of facets according to the present invention outside on perforator or the tube ends and can make the biopsy needle can faster puncture bone and corresponding bone marrow, and can reduce according to the present invention and to take out bone and/or required time and the power of sample of bone marrow from the target area.
The structure at sleeve pipe or outer perforator tip can be changed according to the present invention, with insert with power drill/driver sleeve pipe or outside perforator best torque is provided when obtaining bone and/or bone marrow biopsy sample.Stable during the working power driver, controlled feed rate is compared with manual insertion biopsy needle and can be obtained higher-quality biopsy sample.Can be provided with at least one screw near the corresponding tip or first end in the hollow bushing, to help to obtain bone and/or bone marrow biopsy sample.
The quality of using power drill/driver of the present invention and biopsy needle to obtain the reliability of bone and/or sample of bone marrow and bone and/or sample of bone marrow can be inserted bone and corresponding bone marrow to biopsy needle and improves greatly by adopting best feed rate.Feed rate that biopsy needle of the present invention inserts or speed can be the function of the revolutions per minute (RPM) of the pitch that is located at least one screw thread on the biopsy needle interior section and biopsy needle.
The pitch of RPM=feed rate * screw thread
Fig. 4 C, the pitch of screw 190 shown in 4D and the 4E is about 24 screw threads of per inch.Optimum pitch can change according to the factor of for example gear reduction ratio (being 77: 1 in certain embodiments) and the suffered load of respective motors and so on.
Other technological merit comprises, by improving speed and the control that the pin group is inserted in bone marrow biopsy program and the bone marrow aspiration program process, has reduced physical fitness requirement and psychentonia to user, and has reduced patient's pain and anxiety.
The combination of power drill/driver and biopsy needle group can be used to enter rapidly crista iliaca or other inserts the position to extract corresponding bone and/or sample of bone marrow.Bone marrow biopsy of the present invention system substitutes the existing manual technique that is used for biopsy needle is inserted bone and bone marrow that generally is counted as industry standard with power technology.
In some occasion, aspiration needle of the present invention or biopsy needle can comprise hollow bushing or conduit, and the one end forms with spark machined (EDM) technology, grinding process and/or other process for machining.Can use electrical discharge machining (EDM) technology, grinding process and/or other process for machining on an end of sleeve pipe or conduit, to form a plurality of teeth.
In certain embodiments, also can be provided with the trocar or stylet in sleeve pipe or the conduit, first end of stylet stretches out from first end of sleeve pipe or conduit.Increase length that the trocar or stylet first end stretch out from sleeve pipe or conduit first end can reduce to puncture required torque of bone or power, and can shorten corresponding aspiration needle group or biopsy needle group puncture bone and corresponding bone marrow required time.
The general torque that produces when boring os osseum or cartilage of specific power drill/driver, intraosseous device and pointed tip configuration is identical.But it is general longer than piercing the similar degree of depth required time of cartilage to pierce os osseum first degree of depth required time.
In further embodiments, the tooth that is formed on sleeve pipe or conduit one end can be radially outward crooked, to reduce to use sleeve pipe or conduit puncture bone and corresponding bone marrow required time and/or power.In some occasion, power drill/driver of the present invention and aspiration needle group or biopsy needle group can provide the path that enters patient's bone marrow with the torque of analog quantity.Compare with the time that puncture is required than the coward, increased the unyielding time of puncture.
Adopt coolant slowly a plurality of stylets of grinding the present invention and telescopic tip, to prevent that being used for making stylet and telescopic metal alloy or elastomeric material suffers possible cause thermal damage.Stylet becomes each IO pin group with sleeve-assembled.Under the controlled test condition, the tip of each pin group is inserted in surgeon's test block.Some tests have been carried out with Pacific Research surgeon test block.Power and 12V unidirectional current (12VDC) with 10 pounds (lbs) are added on the corresponding power drill/driver, and pin group tip is inserted into about 2cm degree of depth.Stylet or cannula tip did not have wearing and tearing that can survey or visible after test was finished.
In certain embodiments, when inserting the selected target district, can under optimum speed or RPM, rotate roughly hollow biopsy needle substantially continuously with the acquisition biopsy sample.Biopsy needle can comprise from the vertical hole of pin first opening to the extension of second opening.Can be formed with little screw near on vertical hole interior section of first end.In certain embodiments, the pitch of this screw thread can be similar to the screw thread of use on the normal wood screw.By the gear drive with required speed reducing ratio (being generally 60: 1～80: 1) is installed, just can select the rotating speed or the revolutions per minute (RPM) of biopsy needle between motor and respective drive axle.In some occasion, gear drive can reduce the rotating speed of the motor that links to each other with the ratio of about 66: 1 or 77: 1.
Outer perforator shown in Fig. 3 F or sleeve pipe 110f can comprise the first end 111f, and the first end 111f has a plurality of facet 114f of opening 116 formation of the contiguous first end 111f.Opening 116 can be communicated with and constitute the part in vertical hole or chamber 118 with corresponding vertical hole or chamber 118.In some occasion, facet 114f can form with electrical discharge machining (EDM) technology.
In Fig. 3 G illustrated embodiment for example, outer perforator or sleeve pipe 110g can comprise the first end 111g, and it is general conical or compares reduced diameter with sleeve pipe 110g other parts.End 111g goes up adjacent openings 116 can be provided with a plurality of facet 114g.In some occasion, facet 114g can form with grinding process.In certain embodiments, the end 111g of sleeve pipe 110g can comprise the facet 114g that 6 grindings form, and can be formed with corresponding bizet 115 between the facet 114g.Being formed with the biopsy needle group of tapered end 111g and a plurality of facet 114g and bizet 115 and/or biopsy needle can improve when biopsy needle group and/or biopsy needle use with power drill/driver of the present invention and pierce performance.
In some occasion, vertically can be formed with helicla flute 117 near opening 116 in the hole 118.Helicla flute 117 can help biopsy sample or sample of bone marrow are retained in vertical hole 118.
The test shows that sleeve pipe of the present invention or outer perforator are carried out forms velocity ratio that facet or cutting teeth cause respective sleeve or outer perforator can bore deep and corresponding bone marrow sometimes with spark machined (EDM) and has with the sleeve pipe or the outer perforator outline of the facet of grinding process formation fast.Some test result also shows, be bent to form sleeve pipe of the present invention or outside facet on perforator one end can reduce and take out bone and/or required time and/or the power of sample of bone marrow from the target area.
Fig. 3 I and 3J illustrate pin group or biopsy needle group 100g in the bone.Biopsy needle group 100g can comprise sleeve pipe or outer perforator 110g, wherein is provided with stylet or interior perforator 120g slidably.Fig. 3 I and 3J illustrate first end 101 of biopsy needle group 100g.In some occasion, first end 101 of biopsy needle group 100g can make inserting the injury minimum of position skin and health soft tissue.
In some occasion, interior perforator or trocar 120g can comprise first end 121, are formed with a plurality of from corresponding most advanced and sophisticated 123 facets 125 and 126 to the trocar or the extension of interior perforator 120g second end on its exterior section.In some occasion, one or more facets 125 can form has the length 127 that extends to the corresponding facet 114g of respective sleeve 110g from tip 123.With each facet 125 adjacent one or more facet 126 that form with second length 128.First length, 127 to the second length 128 are long.The ratio of first length 127 and second length 128 can change according to the present invention, so that performance the best of selected bone of puncture and corresponding bone marrow.
In some occasion, the vertical hole or the intracavity of biopsy needle of the present invention, sleeve pipe, conduit or outer perforator can be provided with single screw thread.Various technologies and method be applicable to being formed in this single screw thread roughly in hollow bushing or the outer perforator near this sleeve pipe or outer perforator one end place, and this sleeve pipe or outer perforator have an end of can be used to puncture bone and/or corresponding bone marrow.In certain embodiments, structure and size and the corresponding spiral winding of this single screw thread can place plug for example on the end of spot-wedling electrode assembly.What then, this plug or electrode assemblie can insert sleeve pipe or outer perforator is used for puncturing in the opening of an end of bone and/or corresponding bone marrow.Then, this spiral winding can combine with telescopic adjacent part.The coil of various structures and size is applicable to this single screw thread is arranged in the biopsy needle.
In Fig. 4 A-4E illustrated embodiment for example, each example of being located at the screw in biopsy needle of the present invention or the sleeve pipe is shown.Outer perforator shown in Fig. 4 A or sleeve pipe 110h can be formed with from opening 116 and pass vertical hole 118 or the chamber 118 that sleeve pipe 110h extends.Electrode assemblie or plug 160 are used in the chamber 118 and near opening 116 places (spot welding) single screw are installed.
Spiral winding 192 shown in Fig. 4 B can place on electrode assemblie 160 first ends 161.The cross section of spiral winding 192 is triangle at right angles.First end or copper electrode 161 can have suitable structure and size, so that be received in slidably in the opening 116 in first end 111 that is formed at sleeve pipe or outer perforator 110h.First end or the copper electrode 161 of plug 160 can comprise corresponding grooves 164, and groove 164 has and is suitable for spiral winding 192 is received in wherein structure and size.Groove 164 can form have when connect with sleeve pipe 110h interior section or in conjunction with the time pitch of fitting mutually with screw thread 190.
In some occasion, electrode assemblie 160 can comprise external diameter expansion section or the plastic insulation 194 adjacent with first end 161.The size of copper electrode 161 and plastic insulation 194 and/or structure may be selected to and be fit to spiral winding 192 is installed in the optimum position that is used for keeping biopsy sample for end 116 in chamber 118.For example, the size of plastic insulation 194 may be selected to the end of outer perforator or the close bizet 115 of sleeve pipe 110h with structure and contacts.
The copper electrode that spiral winding 192 is housed 161 of electrode assemblie 160 can insert in the opening 116 of the sleeve pipe 110h first end 111h.Electrode assemblie 160 can be used to copper electrode 161 conduction, thus 192 of spiral windings are welded in sleeve pipe 110h vertical hole 118 adjacent inner partly on.In certain embodiments, plug 160 can be made spiral winding 192 laser weld with being suitable in the vertical hole of sleeve pipe 110h or the material on 118 interior sections of chamber.When be connected sleeve pipe or outside on the interior section of perforator 110h the time, spiral winding 192 can constitute single screw thread, it has the shoulder 191 that generally perpendicularly extends with the adjacent inner part in chamber 118.The size of screw 190 and structure may be selected to bone and/or sample of bone marrow are retained on the shoulder 191 of the screw thread 190 in the chamber 118 best.
Fig. 4 C illustrates the sleeve pipe 110c of biopsy needle 100c, wherein is provided with screw 190.The combination of screw 190 and the shoulder 191 that substantially vertically extends with chamber 118 interior sections can improve the reliability that biopsy needle 100c keeps bone and/or sample of bone marrow.In some occasion, when biopsy needle 100c used with power drill/driver of the present invention, screw 190 can improve the reliability that obtains satisfied bone sample greatly with the combination of facet 114 and bizet 115.
Screw 190 can be located on the optimum position for the opening 116 of sleeve pipe 110c, to begin to obtain sample of bone marrow or spongy bone core.By to insert biopsy needle 100c with the corresponding best feeding of the pitch of screw 190, screw 190 can " screw in " spongy bone that enters opening 116, to improve the probability of obtaining satisfied biopsy sample or bone marrow core greatly.
In Fig. 4 D illustrated embodiment for example, sleeve pipe or outer perforator 110d can comprise the first end 111d, be formed with on the first end 111d from the first end 111d extend a plurality of outside facet 114d.The length of facet 114d can be longer than the length of corresponding facet 114.Can be formed with each bizet 115d between adjacent facet 114d and the 114g.
In some occasion, the outer perforator of the present invention or telescopic vertical hole or intracavity can be provided with the roughly screw of " wedge shape " of the similar equilateral triangle of cross section.For example, sleeve pipe 110d can comprise the screw 190a of the approximate wedge shape of the approximate equilateral triangle of cross section.Above can adopting, screw 190a is installed in the sleeve pipe 110d at screw 190 described equipment and method.
Fig. 4 E example illustrates by interior perforator or stylet 120c and the sleeve pipe of screw 190 is arranged or the biopsy needle group 100c of the present invention that outer perforator 110c combines in it.Biopsy needle 100c does not have the stylet or the trocar shown in Fig. 3 C and the 4C.In the sleeve pipe 110c of the 100c of biopsy needle group shown in Fig. 4 E the trocar or stylet 120c are arranged.Trocar 120c can comprise end 121c, and shown in Fig. 3 I, this end 121c has a pair of facet 125 and a pair of facet 126. Facet 125 and 126 can be worked in coordination, to form the such cutting tip of similar " chisel edge " drill bit on the trocar or stylet 120c.These can be with respect to this to facet 126 skew (angle of reliefs) about 8 ° to facet 125.Angle between two facets 125 is about 34 ° ± 4 °.Angle between two facets 126 is about 16 ° ± 3 °.
In some occasion, the end 121 of trocar 120c can be extended from sleeve pipe 110c end 111c, and an end opposite with trocar 120c tip 123 of each facet 114 of sleeve pipe 110g and each facet 126 (short facet) is adjacent.See Fig. 4 E.Therefore, the part of each facet 125 (long facet) of trocar 120c can be positioned at the end 111 of sleeve pipe 110c.See Fig. 4 E.
The part of facet 125 being located in the end 111 of sleeve pipe 110c can be so that the end 101 of intraosseous device 100c be stressed more even when using biopsy needle group 100c of the present invention and power drill/driver to puncture corresponding bone cortex.After piercing through cortex, the power that is applied to biopsy needle group 100c end 101 can be reduced to is enough to show that end 101 has entered in the corresponding bone marrow.Then, the operator can extract trocar 120c out from sleeve pipe 110c, and places the end 111c of sleeve pipe 110c the predeterminated target district to carry out bone marrow biopsy.
In certain embodiments, screw thread 190 and 190a can extend about 0.005 inch from the adjacent part in corresponding vertical hole or chamber 118.Respective sleeve pin shown in Fig. 4 E for example external diameter of trocar 120c can be reduced to the height that adapts to screw thread 190 or 190a.When for example biopsy needle group 100c inserts in the surgeon's material of 50 pounds of (50#) 3mm and 40 pounds of (40#) 40mm or the test block intraosseous device shown in Fig. 4 E, draw following test result.
| Test # | Motor torque (g-cm) | Time (s) |
| 44 | 1101 | 2.23 |
| 45 | 1081 | 2.49 |
| 46 | 1071 | 2.36 |
| 47 | 1081 | 2.50 |
| 48 | 1030 | 2.46 |
| 49 | 1070 | 2.33 |
| On average | 1072 | 2.40 |
The distance that the end of trocar 120c or facet 126 and sleeve pipe 110c go up between the adjacent facet 114 is about 0.14 inch.The facet 114 that the end 111 of sleeve pipe 110c has 6 grindings to form.The external diameter of trocar 120c is about 0.086 inch.
Connector assembly of the present invention can be used as " quick release mechanism ", the IO device is engaged and pulls down with the power drill/driver that is positioned at flexible package bag or sterilizing covers being used for.This class connector assembly can allow the IO device to rotate, and does not damage flexible package bag or sterilizing covers simultaneously.In some occasion, this IO device can be aspiration needle or biopsy needle.One end of connector assembly can be used for forming fluid-tight or fluid barriers with the adjacent part of encapsulation bag or sterilizing covers.Connector assembly of the present invention also can be described as the interface module that is connected on the encapsulation bag.This interface module can be easily with power drill/driver and IO means for engaging or take apart, also can allow simultaneously this power drill/driver with the IO device from inserting position " power inserts and power is extracted ".
Connector assembly of the present invention can be used for " non-sterilization " environment and/or does not require the medical procedure that uses encapsulation bag or sterilizing covers.
Fig. 5 A-5I and 6A-6B illustrate the various examples of connector assembly of the present invention or interface module.Fig. 5 A-5I is power drill/driver 200 of the present invention, connector assembly 250, the sketch map of 250a and 250b and intraosseous device 100b.Connector assembly 250,250a and 250b can comprise respectively that first end, 251, the first ends 251 can be used for an end of intraosseous device, engage releasedly such as but not limited to second end 102 of biopsy needle group 100b.
Except the corresponding second end 272b of the second end 250b of the corresponding second end 272a of the second end 252a of connector assembly 250a and housing unit 270a and connector assembly 250b and housing unit 270b, connector assembly 250,250a can have basic identical or similar parts, function and feature with 250b.Therefore, can be about connector assembly 250 explanations various features of the present invention, because except being connected with encapsulation bag or sterilizing covers, connector assembly 250a and 250b have essentially identical feature.
Connector assembly of the present invention can be placed in medical procedures trays or the tool kit, an end down the other end up, thereby " need not to use hands " just can engage releasedly with power drill/driver or manual driver.For example, connector assembly 250 can be located among the medical procedures trays 20c, and first end 251 inserts in the bearing 58, and second end 252 up.See Fig. 1 C, 1E and 1F.Therefore, operator or user (not illustrating specially) need not Body contact or handle any part of connector assembly 250, just the end 224 of the driving shaft 222 that stretches out from power drill/driver 200 can be inserted second end 252 of connector assemblies 250 and joint releasedly with it.Each feature of the blocking mechanism that " need not to use hands " is below in conjunction with Fig. 5 E, 5F, 5H and 5G explanation.
Shown in Fig. 5 E and 5F, connector assembly 250 can comprise elongation core 260, and housing unit 270 is located on the exterior section of elongation core 260 slidably.Housing unit 270 can comprise respectively and first end 261 of elongation core 260 and first end 271 and second end 272 that second end 262 roughly aligns.In some occasion, elongation core 260 can have the substantial cylindrical structure that is made of the first exterior section 260a and the second exterior section 260b, and shoulder and/or dimple are arranged on it.In certain embodiments, the diameter of the first exterior section 260a can be greater than the diameter of the second exterior section 260b.
Can be provided with for example helical spring 274 of bias mechanism around the exterior section 260a that roughly extends core 260.For example see Fig. 5 E and 5F.First end 275 of helical spring 274 can contact the annular shoulder 284 that is formed on first shell section, 280 interior sections.Second end 276 of helical spring 274 can contact the annular shoulder 278 that is provided with near second shell section, 290 first ends 291.Helical spring 274, annular shoulder 284 and annular shoulder 278 can be worked in coordination, first shell section 280 and second shell section 290 are remained on substantially on first extended position relative to each other.See Fig. 5 A, 5B, 5C, 5E and 5I.Other bias mechanism also can be set between annular shoulder 284 and the annular shoulder 278, such as but not limited to leaf spring and corrugated tube (not illustrating specially).
The annular shoulder 278 relevant with helical spring 274 second ends 276 can extend radially outwardly from substantial cylindrical ring 277.Substantial cylindrical ring 277 can be slidably and is arranged on rotationally on the exterior section 260a of elongation core 260.Annular shoulder 279 can be arranged on the interior section of substantial cylindrical ring 277, and can extend radially inwardly to the adjacent part of elongation core 260.
The exterior section 260a that annular shoulder 268 can be formed on elongation core 260 goes up between first end 261 and second end 262.The structure of annular shoulder 268 and annular shoulder 279 be dimensioned to each other suitable mutually so that engaging between the annular shoulder 268 of the annular shoulder 279 of substantial cylindrical ring 277 and elongation core 260 can limit second shell section 290 to the lengthwise movement of extending on core 260 second ends 262 directions.
In some occasion, a plurality of flexible chucks or folder refer to that 477 can 278 extensions from substantial cylindrical ring 277 in contrast to annular shoulder.On the end opposite that each chuck head 478 can be formed on each chuck 477 with annular shoulder 278.The structure of chuck head 478 and size may be selected to and be received in the slit or opening 297 that is formed in second housing 290.When making connector assembly 250, each chuck head 478 can be arranged in each slit or the opening 297, at first end, 291 places near second shell section 290 substantial cylindrical ring 277 and annular shoulder 278 are firmly engaged.Therefore, second shell section 290 can move with respect to the elongation core 260 and first shell section 280 as individual unit basically with annular shoulder 278.
When intraosseous device and connector assembly 250 first ends 251 were disengaged, first shell section 280 can be in the vertical moves or slides to second shell section 290.Similarly, when power drill/driver and connector assembly 250 second ends 252 were disengaged, second shell section 290 can be in the vertical moves or slides to first shell section 280.
As mentioned above, elongation core 260 can form annular shoulder 268 on the exterior section between first end 261 and second end 262.Engaging between the annular shoulder 279 of annular shoulder 268 and substantial cylindrical ring 277 can be limited second shell section 290 moving to elongation core 260 second ends 262.First shell section 280 vertically moving on elongation core 260 second ends 262 directions when contacting between the annular shoulder 278 of spring 274 and first shell section 280 and the annular shoulder 284 can be limited in intraosseous device and connector assembly 250 first ends 251 and be disengaged.
Substantial cylindrical ring 277 and the annular shoulder 279 that links to each other can be in the longitudinal sliding motions on the exterior section between annular shoulder 268 and the annular shoulder 267 of toroidal cores 260.First shell section 280 can vertically move to elongation core 260 second ends 262, so that first end 251 of an end of intraosseous device and connector assembly 250 is disengaged.In a similar manner, second shell section 290 can vertically move to elongation core 260 first ends 261, so that an end of the driving shaft that stretches out from power drill/driver and second end 252 of connector assembly 250 are disengaged.
Various lockings and blocking mechanism are applicable to an end of intraosseous device is bonded in first end of connector assembly of the present invention releasedly.Similarly, various lockings and blocking mechanism are applicable to an end of the driving shaft that stretches out from power drill/driver or manual driver is bonded in second end of connector assembly of the present invention releasedly.
By connector assembly 250, among the embodiment of 250a and 250b representative, first locking 410 can be arranged on the exterior section near the elongation core 260 of the socket 263 adjacent with first end 261, with an end of IO device for example second end 102 of biopsy needle group 100b be bonded on connector assembly 250 releasedly, in the socket 263 of 250a and/or 250b.Second blocking mechanism 420 can be formed on the exterior section near the elongation core 260 of the socket 264 adjacent with second end 262, engages releasedly with second end 252 of connector assembly 250 with the end with driving shaft.See Fig. 5 C, 5E and 5I.
The end 224 that second locking 420 can be used for driving shaft 222 that the part of driving shaft is for example stretched out from power drill/driver 200 is bonded on connector assembly 250 releasedly, in second end 252 of 250a and/or 250b.Locking 410 can engage intraosseous device with first end 251 of connector assembly 250 releasedly, and same substantially locking 420 can engage power drill/driver with second end 252 of connector assembly 250 releasedly.
In some occasion, locking 410 can have similar structure with 420, for example roughly is " Ω " shape.See the locking 420 among Fig. 5 G and the 5H.But locking 410 can have the corresponding large-size of exterior section 260a basic and elongation core 260.Locking 420 can have the corresponding reduced size of exterior section 260b basic and elongation core 260.Can each feature of the present invention be described in conjunction with the adjacent part of the blocking mechanism 420 shown in Fig. 5 G and the 5H and second shell section 290 and the exterior section 260b of elongation core 260.
Roughly can be formed with pawl 421 and 422 respectively on 420 liang of end opposite of Ω shape locking.See Fig. 5 D, 5G and 5H.Similarly, roughly can be formed with pawl (not illustrating specially) respectively on Ω shape locking 410 two ends.Pawl 421 and 422 structure and size can be suitable for each pawl 421 and 422 is put in each slit or opening 431 and 432 that extends between the interior section of elongation core 260 exterior section 260b and the socket 264 of close connector assembly 250 second ends 252.
Locking 420 can be for example primary importance shown in Fig. 5 D and 5G, and at this moment, pawl 421 and 422 part are passed each slit 431 and 432. Pawl 421 and 422 structure and size can make itself and annular groove 402 firm engagement that are formed in power drill/driver 200 ends 224.Similarly, each pawl in the corresponding locking 410 can engage releasedly with the annular groove 401 in biopsy needle 100b second end 102.
In some occasion, needle stand 140a can be formed with a plurality of taper surfaces 403 (seeing Fig. 5 C) near on the exterior section of first end 142, insert connector assembly 250 at biopsy needle 100b second end 102, in the time of in 250a and 250b first end 251, taper surface 403 radially outward expands the pawl mechanism relevant with Ω shape locking 410.This pawl mechanism can be when aliging with annular groove 401 in " snapping in " annular groove 401.Similarly, can be formed with a plurality of taper surfaces 228 on the exterior section of the end 224 of the driving shaft 222 that stretches out from power drill/driver 200, in the time of in second end 252 of the end of power drill/driver 200 224 insertion connector assemblies 250, taper surface 228 radially outward expands pawl mechanism 421 and 422.When pawl mechanism 421 and 422 aligns with annular groove 402 in " snapping in " annular groove 402.See Fig. 5 F.
Engaging between the pawl mechanism relevant with locking 410 and the annular groove 401 of needle stand assembly 130a will make second end 102 of biopsy needle 100b keep basically engaging with connector assembly 250 first ends 251.This joint allows power drill/driver 200 rotating or fast rotational sleeve pipe or biopsy needle 110b when sleeve pipe or biopsy needle 110b are extracted in the position from inserting.Similarly, the pawl mechanism 421 of Ω shape locking 420 and 422 with the annular groove 402 of power drill/driver 200 ends 224 between engage and will keep engaging of connector assembly 250 second ends 252 and power drill/driver 100 when sleeve pipe 110b is extracted at the position substantially from inserting.
By making first shell section 280, just can unload biopsy needle group 100b from connector assembly 250 first ends 251 to 262 longitudinal sliding motions of elongation core 260 second ends.This of first shell section 280 moves exterior section and the compression Ω shape locking 410 will cause the 286 contact Ω shape lockings 410 of interior tapered face, thereby makes corresponding pawl mechanism's (not illustrating specially) expanded radially and break away from and the engaging of the annular groove 401 of needle stand assembly 130a.Therefore, can from connector assembly 250 first ends 251, easily extract biopsy needle group 100b out.
Similarly, second shell section 290 will cause the exterior section of interior tapered face 296 contact Ω shape lockings 420 to vertically moving of connector assembly 250 first ends 251, to compress roughly Ω shape locking 420, thereby regain or withdrawal pawl mechanism 421 and 422, to break away from and the engaging of the annular groove 402 of end 224.See Fig. 5 F and 5H.Therefore, power drill/driver 200 can be easily separated from one another with second end 222 of connector assembly 250.
The total structure of connector assembly 250 and 250a and size can be basic identical, comprise from second end 252 and radially-protruding each flange 254 of 252a.Flange 254 is expansion infundibulate or toroidal basically.The structure of flange 254 may be selected to the end 211 of power drill/driver 200 with size and conforms to.Connector assembly 250b does not have flange 254.See Fig. 5 I.The housing unit 270b second end 272b can stop near first end 262 of corresponding elongation core 260 and the corresponding second end 252b place of connector assembly 250b.
As mentioned above, connector assembly 250 can be formed on the present invention encapsulate the bag or sterilizing covers in the opening firm engagement.In for example Fig. 5 E and 5F illustrated embodiment, second end 272 of the housing 270 of connector assembly 250 can comprise the annular ring 370 that can be used for the adjacent part firm engagement of flange 254.The external diameter of annular ring 370 is can be basically identical with the external diameter of the adjacent part of flange 254.The internal diameter of annular ring 370 is also can be basically identical with the internal diameter of the adjacent part of flange 254.
In certain embodiments, a plurality of posts 372 and roughly V-shaped groove 374 alternately be arranged on flange 254 ends.Annular ring 370 can comprise that a plurality of sizes are suitable for admitting the hole 371 of post 372.Annular ring 370 also can comprise a plurality of roughly V-arrangement projections 376, its size be suitable for being received in be formed in flange 254 adjacent parts each roughly in the V-shaped groove 374.
At for example Fig. 1 C, 1E, 1F, in 7A and the 7B illustrated embodiment, the part adjacent with first opening 171 of encapsulation bag 170 can be between the adjacent part of annular ring 370 and flange 254.For example, post 372 can pass encapsulation bag 170 and adjacent each hole (not illustrating specially) of opening 171 peripheries.Can align with post 372 in the hole 371 of annular ring 370.Encapsulation bag 170 and opening 171 adjacent other parts can be clamped between V-arrangement projection 376 and the V-shaped groove 374.Can on post 372, use various welding procedures, include but not limited to laser weld, so that the adjacent part of annular ring 370 with flange 354 combined.Therefore, the periphery that encapsulation bag 170 and first opening 171 is adjacent can with connector assembly 250 second ends 252 firm engagement together.See Fig. 7 A and 7B.
Fig. 6 A and 6B are the sketch map of power drill/driver 200a of the present invention, connector assembly 250b and biopsy needle group 100b.Connector assembly 250b can comprise and can be used for first end 251 that engages releasedly with intraosseous device 100b second end 102.Connector assembly 250b also can comprise and can be used for second end 252 that engages releasedly with the end 224a of the driving shaft 222a that stretches out from power drill/driver 200a first end 211.
Shown in Fig. 6 B, biopsy needle group 100b second end 102 can be arranged in connector assembly 250b first end 251 releasedly.The end 224a of the driving shaft 222a that stretches out from power drill/driver 220a end 211 can engage releasedly with connector assembly 250 second end 252b.In the embodiment by connector assembly 250b representative, connector assembly 250b second end 252 can comprise structure and corresponding with the tapering point 224a of the power drill/driver 220a basically tapered socket 264b of size.
In some occasion, connector assembly 250b can comprise the blocking mechanism 430 near second end, 252 settings of connector assembly 250b.Blocking mechanism 430 has partly constructs by being arranged essentially parallel to extend first section 431 of core 260b extension and be substantially perpendicular to second section 432 basic " L " shape that constitutes of extending close second end 262 of core 260b extension.Can comprise that big I allows the end 224a of power drill/driver 200a to insert enlarged openings 434 among the socket 264b for second section 432.The section 432 of blocking mechanism 430 can comprise that also size is suitable for being bonded on releasedly the pawl mechanism 436 near the end 224a of power drill/driver 200a the annular groove 402.See Fig. 6 B.
When connector assembly 250b was connected with the end 224a of power drill/driver 200, available subordinate press first section 431 and compression spring 438 and moving jaws mechanism 436 were to allow to enter fully the socket 264b among the connector assembly 250b second end 252b.The end 224a of power drill/driver 200a can insert among the socket 264b through opening 434 then.Then can unclamp blocking mechanism 430 first section 431, thus pawl mechanism 436 can firmly be bonded in the annular groove 402 of power drill/driver 200a end 224a.Therefore, connector assembly 250b keeps firmly engaging with power drill/driver 200a, up to pressing down first section 430 and make pawl mechanism 436 disengaging annular grooves 402 once more.
In certain embodiments, connector assembly 250b can be provided with annular ring 440 near on the exterior section of second end 252.Annular ring 440 is illustrated among Fig. 6 B.The not shown annular ring 440 of Fig. 6 A.Can be formed with groove 442 on annular ring 440 exterior sections, firmly engage with suitable periphery with encapsulation bag first opening.The size of annular ring 440 and structure may be selected to and allow connector assembly 250b to rotate in annular ring 440.Therefore, the rotation of connector assembly 250b can not damage the encapsulation bag that is connected with annular ring 440 basically.
Fig. 7 A and 7B are sketch map, illustrate and encapsulate the example that bag or sterilizing covers engage with connector assembly according to the present invention.Fig. 7 A illustrates the power drill/driver 200 before being placed in the encapsulation bag 170.Encapsulation bag 170 has first opening 171 and second opening 172 basically.In some occasion, encapsulation bag 170 can be made with material like the plastics of substantially transparent, flexibility.
The big I of first opening 171 is suitable for firmly engaging with connector assembly 250 second ends 252.In the embodiment by connector assembly 250 representatives, the part that available annular ring 370 will encapsulate bag 170 close first openings 171 firmly engages with connector assembly 250 second ends 252.See Fig. 5 E and 5F.Between the adjacent part of near part first opening 171 of encapsulation bag 170 and connector assembly 250 second ends 252, can form fluid barriers.
The size of encapsulation bag 170 second openings 172 and configuration are preferably selected to and can pass for power drill/driver 200.Various closing means engage rear enclosed second opening 172 applicable to the end 224 at power drill/driver 200 with second end 252 of connector assembly 250.In some occasion, flap 174 can close up on second opening 172.Various self sealss jointing materials engage with the adjacent part of encapsulation bag 170 releasedly applicable to the part with flap 174.The invention is not restricted to use the opening on flap and the jointing material sealing encapsulation bag.
Fig. 8 is connector assembly 250c and the exploded perspective sketch map that therefrom stretches out the needle stand assembly 130c of intraosseous device 100d.Intraosseous device 100d first end 101 can be used for inserting bone and corresponding bone marrow.Intraosseous device 100d can comprise the sleeve pipe 110c that stretches out from needle stand 140c.The interior perforator or the trocar 120 can stretch out from needle stand 150c first end 151.The size of needle stand 150c first end 151 is suitable for inserting releasedly in needle stand 140c second end 142.Connector assembly 250c first end 251 can insert in needle stand 150c second end 152 releasedly.In for example embodiment illustrated in fig. 8, connector assembly 250c first end 251, needle stand 150c second end 152, needle stand 150c first end 151 and needle stand 140c second end 142 can be in the form of a substantially rectangular.
Various displacers, discharge bar, funnel and/or displacer funnel also can use with biopsy needle of the present invention, biopsy needle group and/or other intraosseous device.In some occasion, funnel of the present invention can comprise first opening on funnel first end and second opening on second end.The internal diameter of first opening and second opening can be different.
For example, the big I of first opening is inserted for biopsy needle, and the internal diameter of second opening dwindles, thereby prevents that biopsy needle from inserting.The size of second opening is inserted an end of respective row rod only.In some occasion, vertical passage can extend between first opening of funnel and second opening.Can be formed with taper surface on contiguous first end in the vertical passage.Taper surface can be used as " unidirectional " joint, and when inserting wherein with convenient biopsy needle, funnel firmly engages with first end of biopsy needle.Thereby funnel can be used as the tip protector of biopsy needle first end.
Fig. 9 A, 9B and 9C are illustrated in and can be used to from roughly hollow bushing or biopsy needle take out the equipment of biopsy sample and some examples of method after hollow bushing roughly or biopsy needle first end insert in bone and/or the corresponding bone marrow.Funnel 80 shown in Fig. 9 A can comprise first end 81 and second end 82, and roughly hollow cylinder portion 83 extends between first end 81 and second end 82.Roughly hollow cylinder portion 83 can comprise that big I holds the vertical passage (not illustrating specially) of corresponding intraosseous device one end and displacer 90 first ends 91.In some occasion, displacer 90 also can be described as " discharge bar ".
The length in the chamber of the comparable corresponding biopsy needle of length of displacer 90 is long.Can be provided with handle or needle stand 96 on displacer 90 second ends 92.Discharging the size of bar 90 first ends 91 and configuration is chosen to be suitable for the opening that this first end 91 passes in corresponding biopsy needle first end and inserts.
In for example Fig. 9 B and 9C illustrated embodiment, funnel 80a can comprise the first end 81a, and an end of its big I and intraosseous device for example biopsy needle 100c first end 101 firmly engages.Funnel 80a can comprise the second end 82a, and its size is suitable for displacer 90 first ends 91 are received in wherein slidably.Vertical passage 84 can be arranged among the funnel 80a and extend between the first end 81a and the second end 82a.
In some occasion, can be formed with first tapered opening 87 near the first end 81a.Can be formed with second tapered opening 88 near the second end 82a.The big I of first tapered opening 87 is passed and is inserted among first section 84a of vertical passage 84 for the end 101 of biopsy needle 100c.The size of second tapered opening 88 only allows the end 91 of displacer 90 to pass and insert among the diameter diminution part 84b of vertical passage 84.Diameter diminution part 84b is littler than the external diameter of biopsy needle 100c or other intraosseous device.
In some occasion, vertical passage 84 can comprise the 84a of tapered bore portion adjacent with first opening 87 and that extend from first opening 87.The 84a of tapered bore portion can limit biopsy needle 100c first end 101 or other intraosseous device moving therein.Size and the configuration of the 84a of tapered bore portion can become " adhesion taper ", thereby funnel 80a is firmly engaged with intraosseous device first end that inserts wherein.Because " the adhesion taper " that provides in the vertical passage 84 can be taken out funnel 80a from the corresponding bearing of medical procedure tool kit, insert the second end 82a to allow discharging bar 80.Because funnel 80a firmly engages with first end of corresponding intraosseous device this moment, so funnel 80a also can be used as tip protector.
One of advantage of the present invention can comprise, can be with an end and the funnel positive engagement of intraosseous device, and the operator need not to catch funnel or intraosseous device in this engaging process.Power drill/driver of the present invention and connector assembly are applicable to intraosseous device one end is inserted in the funnel.Then, connector assembly can break away from releasedly with another end opposite of intraosseous device.
Advantage of the present invention can comprise, by raising aspiration needle inserts in spongy bone and bone marrow collection program speed and control, thereby alleviates operator and patient's physical fitness requirement and psychentonia.Bone marrow aspiration of the present invention system can comprise battery powered power drill/driver, connector assembly, encapsulation bag and aspiration needle group.Be placed on power drill/driver in the packaged sterile bag be rotatably connected device assembly and the aspiration needle group that is connected thereon, extract bone marrow out to certain depth with puncture bone cortex and corresponding spongy bone.Driver and connector assembly break away from the aspiration needle group then.Can be operatively connected the needle stand assembly on aspiration needle group one end, so that aspiration needle or sleeve pipe are fixed in the bone reliably.Can with standard Luer locked joints (part of needle stand assembly) and standard syringe or from a bone marrow aspiration system stretch out hose connection.
Figure 10 is for being located at the sketch map of the aspiration needle in the hipbone part (usually being called ilium).Usually be used for obtaining the site of puncture of bone marrow or insert one of position to be the back crista iliaca from hipbone.Another inserts the position can be preceding crista iliaca (not illustrating specially).Also can be from tibia (thigh bone) and breastbone (chest) marrow aspiration.
Hipbone 300 shown in Figure 10 can comprise three sections: ilium, ischium and pubis.These three sections differ from one another basically in younger patient, but merge substantially in the adult.Skin and soft tissue 302 cover basically in the ridge 304 of ilium and insert the position.
All bones consist essentially of the tough and tensile cortical layer that is difficult to pierce through.The ridge 304 of hipbone 300 generally comprises cortical layer 306.For seeing clearly Chu Qijian, Figure 10 is the enlarged drawing of skin and soft tissue layer 302 and cortical layer 306.Skin and soft tissue layer 302 general thick 7mm-8mm.Cortical layer 306 general thick about 2mm.
As mentioned above, according to the present invention, bone interior (IO) device or aspiration needle group 100a can insert iliac crest or any other inserts position with minimally invasive acquisition bone and/or sample of bone marrow.
Figure 10 illustrates and uses present device and the method example from the system of bone marrow aspiration.Can use present device and method to include but not limited to that from any suitable bone tibia (thigh bone), ilium (pelvis) or breastbone (chest) obtain bone and/or sample of bone marrow.Figure 10 illustrates sleeve pipe or the aspiration needle 110a that inserts in patient's ilium target area.
In one embodiment, system 310 can comprise vacuum source or low pressure source 312, collection container 314, vacuum tube 316 and collecting pipe 318.Vacuum source 312 can be pump for example shown in Figure 10, or can be the part of hospital or operating room low-voltage vacuum system (not illustrating specially).Vacuum tube 316 can extend between vacuum source 312 and collection container 314.The all kinds pipe is applicable to forming vacuum tube 316 and/or collecting pipe 318.The length of vacuum tube 316 and/or collecting pipe 318 can be according to each facility of using system 310 and difference.
Collecting pipe 318 extends between (IO) adapter assembly 320 in collection container 314 and bone.Various connections and adapter assembly include but not limited to IO adapter assembly 320 be used in the IO device for example between aspiration needle 110a and the collecting pipe 318 fluid be communicated with.
IO adapter assembly 320 can comprise and can be used for the adapter or the pipe joint 322 that engage releasedly with an end opposite with container 314 of collecting pipe 318.Can use and the relevant all kinds of adapters of IV pipe.Short flexible pipe 324 can extend between pipe joint 322 and angle coupling 326.In some occasion, flow control apparatus or pipe backstop 328 can be housed between joint 322 and angle coupling 326 on the flexible pipe 324.
Flow control apparatus 328 can have first open position shown in Figure 10 and second closed position (not illustrating specially).Flow control apparatus 328 is used in and maybe can be connected in any other on the IO adapter assembly 320 with collecting pipe 318 and for example installs that IV pipe (not illustrating specially) engages or prevent that fluid is mobile from IO device 110a when throwing off.
Flow control apparatus 328 can be with making than flexible material, thus compressible or extruding flow control apparatus 328 and recess or hook 330 are engaged with end 332.Compression flow control apparatus 328 can cause clip 334 and 336 compressions best or cut off fluidic flowing in the chamber of flexible pipe 324.Recess 330 will remain on flow control apparatus 328 on second closed position with engaging of end 336.
Angle coupling 326 can close with a termination opposite with joint 322 of flexible pipe 324.Angle coupling 326 allows flexible pipes 324 to be connected with aspiration needle 110a with an angle, thereby does not twist together basically or nip off and manage 324 inner chamber.Angle coupling 326 also can comprise the road strategic point joint 340 that can be used for being connected releasedly with the first needle stand 140a, second end 142.The tapered portion (not illustrating specially) of road strategic point joint 340 can be inserted in the tapered opening 144 that is formed in the first needle stand 140a, second end 142.
Can be provided with lock nut 342 on the exterior section of the adjacent Luer joint 340 of angle coupling 326.Also can be formed with flange 344 on the outside of the adjacent Luer joint 340 of angle coupling 326.Lock nut 342 is rotatable and be slidably disposed on the exterior section of adjacent Luer joint 340 of angle coupling 326, and flange 344 is between the joint 340 in distress of lock nut 342 and road.The screw thread 346 that forms on lock nut 342 interior sections can be used for angle coupling 326 is engaged releasedly with near the first needle stand 140a, second end 142 screw thread 148.
After aspirating required sample of bone marrow from target area shown in Figure 10, can pull down IO adapter assembly 320 from the first needle stand 140a, second end 142.The second needle stand 150a (can be connected with also and can not be connected with the trocar) can be connected with the first needle stand 140a, second end 142 once more.Power drill/driver 200 can be connected with needle stand assembly 130a once more with connector assembly 250, aspiration needle 110a shifted out (power is extracted) or to be inserted into another target area in the hipbone 300.
Although more than describe the present invention and advantage thereof in detail, should understand and in the spirit and scope of the invention that appended claim limits, to make many variations, replacement and change.
Claims (8)
1. be used to obtain the equipment of the biopsy sample of bone and/or corresponding bone marrow, comprise:
Power drill/driver with driving shaft, the part of driving shaft is stretched out from an end of this power drill/driver;
Biopsy needle group with first end of be used to puncture bone and corresponding bone marrow;
Connector assembly, its first end are used for engaging releasedly with this biopsy needle group second end;
Second end of this connector assembly is used for engaging releasedly with the described part of the driving shaft that stretches out from the described end of power drill/driver;
This biopsy needle group comprises the sleeve pipe with first end and second end, and vertically the hole extends through sleeve pipe to sleeve pipe second end from sleeve pipe first end;
Be formed on the opening of sleeve pipe first end;
Be arranged on a plurality of facets of close described opening on sleeve pipe first end;
Described facet be used to puncture bone and corresponding bone marrow; And
Be located near the single screw thread on the vertical hole of the sleeve pipe interior section of sleeve pipe first end opening, this single screw thread comprises the shoulder that vertically extends with the vertical hole of sleeve pipe interior section, so that make sleeve pipe can keep the bone marrow biopsy sample.
2. by the described equipment of claim 1, it is characterized in that this single screw thread further comprises:
Cross section is the coil of the roughly spiral of wedge shape, and this wedge-shaped cross-section is partly limited by the base portion wideer than spiral winding other parts; And
The base portion of described wedge-shaped cross-section combines with the vertical hole of adjacent bushings interior section.
3. by the described equipment of claim 2, it is characterized in that, further comprise:
One side of this cross section is substantially perpendicular to described base portion and extends; And
The base portion of described spiral winding is welded on the interior section of the vertical hole of adjacent bushings.
4. by the described equipment of claim 1, it is characterized in that, further comprise:
Have the encapsulation bag that can seal opening, this size that can seal opening allows this power drill/driver to place in this encapsulation bag;
Connector assembly first end is located at outside this encapsulation bag;
Connector assembly second end is located in the encapsulation bag.
5. by the described equipment of claim 4, it is characterized in that, further comprise being formed on adjacent encapsulation bag part and the fluid barriers between the connector assembly exterior section.
6. by the described equipment of claim 1, it is characterized in that, further comprise:
Power drill/driver with gear drive;
Described single screw thread has pitch; And
This gear drive has the synchronous speed reducing ratio of pitch with motor rotary speed and this single screw thread, so that the biopsy needle group is obtained performance the best of sample of bone marrow.
7. by the described equipment of claim 1, it is characterized in that this power drill/driver further comprises:
The gear drive that is located between motor and the driving shaft and engages rotationally with motor and driving shaft; And
The speed reducing ratio of this gear drive is chosen to make the biopsy needle group to insert in the target area best.
8. by the described equipment of claim 7, it is characterized in that, further comprise: this gear drive is used for the revolutions per minute (RPM) with the best rotates this driving shaft, connector assembly and thereby the biopsy needle group that is installed on the connector assembly is obtained the bone marrow biopsy sample.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82532506P | 2006-09-12 | 2006-09-12 | |
| US60/825,325 | 2006-09-12 | ||
| US91012207P | 2007-04-04 | 2007-04-04 | |
| US60/910,122 | 2007-04-04 | ||
| PCT/US2007/078204 WO2008033872A2 (en) | 2006-09-12 | 2007-09-11 | Biopsy devices and related methods |
Publications (2)
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| CN101516274A CN101516274A (en) | 2009-08-26 |
| CN101516274B true CN101516274B (en) | 2011-10-19 |
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| CNA2007800011964A Pending CN101355981A (en) | 2006-09-12 | 2007-09-11 | Medical procedures trays and related methods |
| CN2007800011983A Active CN101365390B (en) | 2006-09-12 | 2007-09-11 | Apparatus for biopsy and aspiration of bone marrow |
| CN200780001188XA Active CN101534740B (en) | 2006-09-12 | 2007-09-11 | Medical procedures trays with endosseous device |
| CN2007800011907A Active CN101516274B (en) | 2006-09-12 | 2007-09-11 | Biopsy devices and related methods |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
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| CNA2007800011964A Pending CN101355981A (en) | 2006-09-12 | 2007-09-11 | Medical procedures trays and related methods |
| CN2007800011983A Active CN101365390B (en) | 2006-09-12 | 2007-09-11 | Apparatus for biopsy and aspiration of bone marrow |
| CN200780001188XA Active CN101534740B (en) | 2006-09-12 | 2007-09-11 | Medical procedures trays with endosseous device |
Country Status (1)
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| CN (4) | CN101355981A (en) |
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| US20110190781A1 (en) * | 2010-02-03 | 2011-08-04 | Nicholas John Collier | Surgical retrieval apparatus |
| US8801713B2 (en) | 2011-04-07 | 2014-08-12 | DePuy Synthes Products, LLC | Surgical drill instrument with motor and locking mechanism to receive an attachment and a cutting burr |
| KR101815453B1 (en) * | 2011-04-07 | 2018-01-05 | 신세스 게엠바하 | Surgical drill instrument with motor and locking mechanism to receive an attachment and a cutting burr |
| US8690876B2 (en) | 2011-04-07 | 2014-04-08 | DePuy Synthes Products, LLC | Cutting burr shank configuration |
| CN102217955B (en) * | 2011-05-05 | 2012-10-17 | 单建林 | Bone biopsy needle |
| US9414816B2 (en) * | 2011-06-23 | 2016-08-16 | Devicor Medical Products, Inc. | Introducer for biopsy device |
| CN102247174B (en) * | 2011-08-18 | 2013-06-12 | 南京大学医学院附属鼓楼医院 | Combined minimally invasive cutting biopsy device for bone tumour |
| WO2014022567A1 (en) * | 2012-07-31 | 2014-02-06 | Safe Wire Holdings, Llc | Depth controlled jamshidi needle |
| FR3007636B1 (en) * | 2013-07-01 | 2016-09-02 | Laurent Fumex | TROCART PERFORANT. |
| FR3013958B1 (en) * | 2013-12-03 | 2017-11-03 | Thierry Masseglia | TROCART A BIOPSY. |
| WO2015120262A1 (en) * | 2014-02-07 | 2015-08-13 | Vidacare LLC | Assistive device for removing a biological sample from an intraosseous device, and related kits and methods |
| US10092320B2 (en) | 2014-02-17 | 2018-10-09 | Teleflex Medical Devices S.A.R.L. | Powered driver actuated by force on driveshaft and related kits, components, and methods |
| CN104739457B (en) * | 2015-04-16 | 2017-04-12 | 北京德迈特科技发展有限公司 | Electric bone biopsy device |
| EP3308716A4 (en) * | 2015-06-10 | 2019-01-30 | Olympus Corporation | Biopsy needle |
| CN105230760A (en) * | 2015-09-02 | 2016-01-13 | 临泽中云数据有限公司 | Equipment for sucking grease in livestock bones |
| FR3047890B1 (en) * | 2016-02-22 | 2021-04-30 | Laurent Fumex | DEVICE FOR THE STERILE COUPLING OF A PERCUTANE SURGICAL INSTRUMENT AND A TRAINING TOOL AND METHOD FOR PERFORMING SUCH COUPLING |
| US11071562B2 (en) * | 2016-02-25 | 2021-07-27 | Lalu Joseph | Reusable universal tissue morcellator system |
| KR102607362B1 (en) * | 2017-11-07 | 2023-11-29 | 니프로 가부시키가이샤 | instrument for puncture |
| CN108578880B (en) * | 2018-02-13 | 2024-04-05 | 上海长海医院 | Portable intramedullary injection system |
| AU2019264954B2 (en) * | 2018-05-11 | 2021-11-18 | Teleflex Life Sciences Limited | Intraosseous access device and method to access bone marrow |
| CN110882066B (en) * | 2019-12-30 | 2021-06-04 | 青岛大学附属医院 | Clinical department is with anesthesia treatment device of being convenient for operation |
| CN111168333A (en) * | 2020-01-17 | 2020-05-19 | 苏州市美新迪斯医疗科技有限公司 | Preparation method of variable-diameter low-resistance biopsy needle device and product thereof |
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| CN113331923B (en) * | 2021-04-21 | 2022-11-11 | 四川大学华西医院 | Bone channel infusion device |
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| EP1421907A1 (en) * | 2001-08-09 | 2004-05-26 | Japan Immunoresearch Laboratories Co., Ltd. | Marrow fluid sampling set and marrow needle |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101534740A (en) | 2009-09-16 |
| CN101365390B (en) | 2011-02-16 |
| CN101534740B (en) | 2012-06-20 |
| CN101355981A (en) | 2009-01-28 |
| CN101516274A (en) | 2009-08-26 |
| CN101365390A (en) | 2009-02-11 |
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