CA2744117A1 - Uveoscleral drainage device - Google Patents

Uveoscleral drainage device Download PDF

Info

Publication number
CA2744117A1
CA2744117A1 CA2744117A CA2744117A CA2744117A1 CA 2744117 A1 CA2744117 A1 CA 2744117A1 CA 2744117 A CA2744117 A CA 2744117A CA 2744117 A CA2744117 A CA 2744117A CA 2744117 A1 CA2744117 A1 CA 2744117A1
Authority
CA
Canada
Prior art keywords
eye
insertion head
shunt
forward end
conduit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2744117A
Other languages
French (fr)
Inventor
Milton B. Shields
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yale University
Original Assignee
Yale University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yale University filed Critical Yale University
Publication of CA2744117A1 publication Critical patent/CA2744117A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007Methods or devices for eye surgery
    • A61F9/00781Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment

Abstract

A use of a ophthalmic shunt implantable in an eye having an elongate body and a conduit for conducting aqueous humor from an anterior chamber of the eye to the suprachoroidal space of the eye, for treating glaucoma and lowering eye pressure. The elongate body has a forward end and an insertion head that extends from the forward end.
The insertion head defines a shearing edge suitable for cutting eye tissue engage thereby.
The forward end and the insertion head of the body define a shoulder surface.
The conduit has a first end defined on a portion of a top surface of the insertion head.
The conduit also extends through the body from the forward end to a back end thereof. The first end of the conduit is spaced from the shearing edge and, in one example, from the shoulder of the body.

Description

TITLE OF THE INVENTION
UVEOSCLERAL DRAINAGE DEVICE

This application is a divisional of Canadian patent application Serial No.
2,493,010 filed internationally on July 21, 2003 and entered nationally on January 19, 2005.

FIELD OF THE INVENTION

The invention relates to eye implants, more particularly, to an ophthalmic shunt and method of using same for use in enhancing uveoscleral drainage in the eye to lower eye pressure.

BACKGROUND OF THE INVENTION

Glaucoma, a leading cause of world blindness, is a group of disorders, characterized by irreversible damage to the optic nerve, or glaucomatous optic neuropathy, in which elevated intraocular pressure is the main causative risk factor. The only proven way to prevent the blindness of glaucoma is to control the intraocular pressure.
Clinical management of intraocular pressure can be achieved medically or surgically.
Modern medical therapy for glaucoma began in the 1870s, with the introduction of pilocarpine and other cholinergic agonists. In the twentieth century, several compounds were introduced, such as alpha-2 agonists, beta-adrenergic antagonists, topical and systemic carbonic anhydrase inhibitors, and prostaglandins. However, glaucoma medication are not available or practical in many parts of the world, and are inadequate in many patients, despite availability. Hence the need for surgical methods to control the intraocular pressure.
Control of intraocular pressure can be achieved surgically by reducing the production of aqueous humor or by increasing its outflow. Operations to reduce production, referred to collectively as cyclodestructive surgery, destroy a portion of the ciliary body, the source of aqueous humor. Destructive elements over the years have included diathermy, cryotherapy and, most recently, laser energy. While these operations are effective in lowering the intraocular pressure, and are beneficial in desperate cases, they have a high complication rate, including inflammation and further reduction in visual acuity.

Referring to Fig. 1, after production by the ciliary body, aqueous humor leaves the eye by many routes. Some goes posteriorly through the vitreous body to the retina, while most circulates in the anterior segment of the eye, nourishing avascular structures such as the lens and cornea, before outflow by two main routes: canalicular or uveoscleral.
The canalicular, also referred to as the trabecular or conventional, route is the main mechanism of outflow, accounting for approximately 80% of aqueous egress from the normal eye. The route is from the anterior chamber angle (formed by the iris and cornea), through the trabecular meshwork, into Schlemm's canal. The latter is a 360 channel just peripheral to meshwork. It is connected to intrascleral outlet channels that take the aqueous through the sclera to reunite with the blood stream in the episcleral veins.
The uveoscleral route is less clear with regard to anatomy and physiologic significance, but probably accounts for 10-20% of aqueous outflow in the normal human eye.
As with the canalicular route, the uveoscleral pathway begins in the anterior chamber angle.
The aqueous is absorbed by portions of the peripheral iris, the ciliary body and probably the trabecular meshwork, from whence it passes posteriorly through the longitudinal muscle of the ciliary body to the suprachoroidal space (between the choroids and sclera). Aqueous in the suprachoroidal space may pass as far posteriorly as the optic nerve and leave the eye through a variety of emissaria around nerves and vessels in the sclera.
A majority of operations that have been devised to enhance the aqueous outflow as a means of treating glaucoma have focused on enhancing canalicular outflow. The ideal glaucoma operation would be to re-establish normal canalicular flow into Schlemm's canal.
In some forms of glaucoma this is possible, such as the iridectomy (introduced in the 1850s) for pupillary block glaucoma and goniotomy and trabeculotomy (introduced in the mid-twentieth century) for congenital glaucoma. For the vast majority of glaucomas, however, the obstruction to outflow (and, hence, the elevated intraocular pressure) is in the trabecular meshwork, and the only effective surgical approach has been to bypass the normal canalicular pathway and create bulk outflow by one of two methods: filtration surgery and drainage implant devices.

Filtration surgery was introduced in the first decade of the twentieth century. The basic principle is the creation of a fistula through trabecular meshwork, Schlemm's canal and sclera. Aqueous flows through the fistula to create a pool beneath the elevated conjunction (called a bleb), through which it filters to wash away in the tear film. The basic operation, in a variety of modified forms, has now been the preferred glaucoma procedure for nearly 100 years, despite serious limitations.
Limitations of filtering surgery include failure due to fibrotic closure of the fistula.
Of even greater concern are the complications associated with excessive outflow, which include an intraocular pressure that is too low (hypotony) and a conjunctival filtering bleb that becomes too thin, with leakage and the risk of infection (endophthalmitis).
Drainage implant surgery was developed primarily to overcome the problem of fistula closure, since a conduit passes from the anterior chamber angle, through the fistula, to a plate beneath the conjuctiva. However, these operations are also complicated by early hypotony and late failure due to obstruction of the conduit or excessive fibrosis over the plate. There is a need, therefore, for a device and method of using same that reliably channels aqueous into pathways without creating hypotony or a filtering bleb.

Although the uveoscleral pathway may only account for 10-20% of aqueous outflow in the normal state, there is evidence that it can be enhanced to accommodate a significantly greater percentage of outflow. For example, topical prostaglandins, which work nearly exclusively by increasing uveoscleral outflow, can lower the intraocular pressure by 30-50%
in some patients. Even more compelling are the results of early surgical attempts to enhance uveoscleral outflow.

In the first decade of the twentieth century, paralleling the introduction of filtering surgery, an operation was devised to enhance uveoscleral outflow, called cyclodialysis.
Referring to Figures 2A and 2B, the basic principle is separation of the ciliary body from the scleral spur, which provides a direct route for aqueous flow from the anterior chamber angle to the suprachoroidal space. Unlike filtering surgery, however, cyclodialysis enjoyed only limited acceptance in the twentieth century. Although it was commonly used during the first half of the century, serious limitations led to its virtual abandonment by mid-century. The limitations were two-fold. When so-called cyclodialysis cleft was patent, the operation often worked too well, with significant hypotony. In many patients, the cleft would close suddenly, with a profound rise in the intraocular pressure.
A variety of efforts have been made to prevent closure of the cleft by wedging flaps of ocular tissue or plastic devices into the space. To date, none of these techniques have proved success.
SUMMARY OF THE INVENTION

The present invention relates to eye implant devices for lowering intraocular pressure in an eye. In one example, an ophthalmic shunt suitable for implantation in an eye is provided. In this example, the shunt has an elongate body and a conduit for conducting aqueous humor from an anterior chamber of the eye to the suprachoroidal space of the eye.
The elongate body has a forward end and an insertion head that extends from the forward end. The insertion head defines a shearing edge suitable for cutting eye tissue engaged thereby. Together, the forward end and the insertion head of the body define a shoulder surface.
In one example, the elongate body may have a substantially fusiform cross-sectional shape. The elongate body may also have an arcuate shape along at least a portion of its length with a radius of curvature suitable for extending along the curvature of the sclera of the eye.
The conduit of the shunt has a first end defined on a portion of a top surface of the insertion head. The conduit also extends through the body from the forward end to a back end thereof. The first end of the conduit is spaced from both of the shearing edge and the shoulder of the body. The conduit may be formed of a porous wicking member suitable for regulating the flow of aqueous humor from a first end to a second end of the conduit.
Alternatively, the wicking member may be disposed within at least a portion of the conduit.
The shunt may be readily implanted within the eye of a patient in order to reduce the intraocular pressure within the eye. In one example, a first incision in and through the conjunctiva and the sclera at a position posterior to the limbus is made. The shunt is then grasped by the surgeon with, for example, a surgical tool, whereupon the insertion head of the shunt is passed through the first incision and into the supraciliary space of the eye. Next, at least a portion of the shearing edge of the insertion head is inserted into and through the anterior chamber angle into the anterior chamber of the eye. When the insertion head is inserted within the anterior chamber, the first end of the conduit is placed in fluid communication with the anterior chamber and the second end of the conduit is placed in fluid communication with the suprachoroidal space. Thus, aqueous humor is allowed to flow from the anterior chamber of the eye to the suprachoroidal space, which allows the intraocular pressure in the eye to be lowered.
In use, the shunt prevents cleft closure and controls the rate of aqueous flow into the suprachoroidal space via the conduit, which prevents hypotony. Thus, the design of the present invention overcomes the limitations inherent in the traditional cyclodialysis procedure: hypotony and cleft closure.
According to one aspect, the invention relates to an ophthalmic shunt implantable in an eye, comprising: an elongate body having a forward end, a spaced back end, and an insertion head extending from the forward end of the elongate body, the insertion head having a top surface and defining a shearing edge constructed and arranged for cutting eye tissue engaged thereby, the body having a substantially fusiform cross-sectional shape, a junction of the forward end and the insertion head of said body further defining a shoulder surface, said shoulder extending laterally along the forward end of the elongate body; and an enclosed conduit having a first end defined on a portion of the top surface of said insertion head and extending through said body from the forward end to the back end thereof, the first end being spaced from the shearing edge and the shoulder surface of said body.
The elongate body has a lower surface, and a portion of the insertion head may be substantially co-planar to the lower surface thereof. The elongate body may have an arcuate shape along at least a portion of its length that is adapted to extend along the curvature of the sclera. The elongate body has an upper surface and a spaced lower surface. At least one planar surface may be constructed and arranged for grasping by a surgical tool is defined on at least a portion of at least one of the respective upper and lower surfaces of the elongate body.
According to another aspect, the conduit comprises a wicking member which may be disposed within at least a portion of the conduit, constructed and arranged for regulating the flow of aqueous humor from an inlet end to an outlet end of the wicking member.
In another aspect, the body defines a longitudinally extending bore. A
proximal end of the bore is defined in the forward end of the body, the proximal end positioned adjacent a portion of the top surface of the insertion head. The shunt includes a junction of the forward end and the insertion head of said body further defining a shoulder surface, said shoulder extending laterally along the forward end of the elongate body; and a tube of biocompatible material, the tube having a first end and a spaced second end, at least a portion of the tube positioned within the bore of said body such that the second end of the tube is adjacent a distal end of the bore of said body and such that the first end of the tube extends through the proximal end of the bore and overlies a portion of the top surface of the insertion head, the first end of the tube being spaced from the shearing edge and the shoulder surface of said body.
DETAILED DESCRIPTION OF THE DRAWINGS

Fig. 1 is a partial cross-sectional view of an eye showing the normal aqueous flow of aqueous humor though the anterior chamber of the eye.
Figs. 2A and 2B are partial top views of an eye showing the prior art cyclodialysis operation and the typical result.
Fig. 3A is a perspective view of a first embodiment of the present invention.
Fig. 3B is a perspective view of the embodiment shown in Fig. 3A being grasped by a surgical tool.
Fig. 3C is a cross-sectional view of the embodiment shown in Fig. 3A taken along line 3A.
Fig. 4A is a perspective view of an elongate body of a second embodiment of the present invention.
Fig. 4B is a perspective view of an elongate conduit of the second embodiment of the present invention.
Fig. 4C is a perspective view of the second embodiment with the elongate conduit shown in Fig. 4B disposed within a portion of the elongate body and overlying a portion of a top surface of an insertion head.
Fig. 4D is a perspective view of the second embodiment shown in Fig. 4C being grasped by a surgical tool.
Fig. 5A is a perspective view of an elongate body of a third embodiment of the present invention.
Fig. 5B is a perspective view of an elongate wicking member having an inlet end and an outlet end.
Fig. 5C is a perspective view of the third embodiment with the elongate wicking member shown in Fig. 5B disposed within a slit of the elongate body and overlying a portion of a top surface of an insertion head.

Fig. 5D is a perspective view of the third embodiment of Fig. 5C being grasped by a surgical tool.

Fig. 6A is a partial top view of an eye having an implant, according to the present invention, being positioned into the anterior chamber of the eye.
Fig. 6B is an enlarged cross-sectional detail view of the implant of Fig. 6A.
Fig. 7A is a partial top view of an eye in which an implant according to the present invention is located therein postoperatively.
Fig. 7B is an enlarged cross-sectional detail view of the implant of Fig. 7A.
DETAILED DESCRIPTION OF THE INVENTION

The present invention is more particularly described in the following examples that are intended as illustrative only since numerous modifications and variations therein will be apparent to those skilled in the art. Thus, the embodiments of this invention described and illustrated herein are not intended to be exhaustive or to limit the invention to the precise form disclosed. They are chosen to describe or to best explain the principles of the invention and its application and practical use to thereby enable others skilled in the art to best utilize the invention. As used in the specification and in the claims, "a," "an," and "the" can mean one or more, depending upon the context in which it is used. The preferred embodiment is now described with reference to the figures, in which like numbers indicate like parts throughout the figures and views.
Referring to Figures 3A-5D, examples of uveoscleral drainage devices of the present invention are shown. The implant or shunt 10 of the present invention comprises an uveoscleral drainage device that is adapted for implantation within an eye of a patient.
Referring initially to Figures 3A-3C, the shunt 10 comprises an elongate body 20 and a conduit 40. The elongate body has a forward end 22, a spaced back end 24, and extends along a longitudinal axis L. The body also has an insertion head 26 that extends generally longitudinally from the forward end thereof. The elongate body further has a first elongate edge 21 and a second elongate edge 23 that extend respectively from the forward end to the back end of the body. The insertion head is adapted for insertion into the anterior chamber of the eye and defines a shearing edge 28 constructed and arranged for cutting eye tissue engaged thereby. In the example shown, the shearing edge of the insertion head may have an arcuate shape. However, as one skilled in the art will appreciate, other shapes, such as, for example, chisel shapes, scalpel shapes, and the like, are contemplated for the shearing edge.
The juncture of the insertion head 26 against the forward end 22 of the body defines a shoulder surface 30 thereon. In one example, the insertion head has a base portion 32 having a first width and where the respective first and second elongate edges are spaced apart a second width that is greater than the first width. The shoulder surface 30 of the body is adapted to engage tissue portions of the anterior chamber angle of the eye that are adjacent an interior surface of the interior chamber. The shoulder surface 30 also aids is limiting the anterior movement or displacement of the device when implanted, which helps prevent the forward end 22 of the drainage device from penetrating and entering the anterior chamber. In the example shown, the base portion of the insertion head 26 extends substantially co-planar to a lower surface 34 of the elongate body. Alternatively, the insertion head 26 may extend from a portion of the forward end that is spaced from the circumferential edge of the forward end. In this example, the shoulder surface 30 would extend about the periphery of the base portion of the insertion head.
The body 20 has a length from the forward end to the back end of such extent to extend from proximate the interior surface of the anterior chamber to the suprachoroidal space of the eye. The back end 24 of the body is adapted for insertion within the suprachoroidal space of the eye. Along at least a portion of its length, the body may be substantially planar or may have an arcuate shape that is adapted to extend along a portion of the curvature of the sclera of the eye. As one will appreciate from the illustrated embodiment, the body is generally thin to provide a less irritating fit within the eye.
In one example, the elongate body 20 has a substantially fusiform cross-sectional shape. This fusiform shape aids in stabilizing the device when implanted as tissues of the anterior chamber angle surround portions of the exterior surface of the body.
A variety of cross-sectional shapes are contemplated for the elongate body as long as a shoulder surface is defined in the forward end.

The conduit 40 has a first end 42 and a spaced second end 44. In the example shown, a portion of the conduit is defined on a portion of a top surface 27 of the insertion head 26 with the remaining portion defined within the elongate body 20 and extending from the forward end to the back end thereof. The first end of the conduit is spaced from the shearing edge 28 and is spaced from the shoulder surface 30 of the body. In one example, the first end 42 of the conduit is positioned at an acute angle with respect to the top surface 27 of the insertion head. In the example shown in Fig. 3A, the conduit is formed integrally with the elongate body. One will appreciate however, and as shown in Figs. 4A-4C, that the conduit may also be a separate member which is connected to the elongate body.

Referring to Figs. 4A to 4C, the conduit 40 of the present invention comprises an elongate tube 50 having a first end 52 and a spaced second end 54. Further, the elongate body defines a longitudinally extending bore 38 therein. A proximal end of the bore is defined in the forward end of the body and is positioned adjacent the top surface of the insertion head. In use, at least a portion of the tube is positioned within the bore of the body such that the second end 54 of the tube is positioned proximate a distal end of the bore.
Further, the first end 52 of the tube extends through the proximal end of the bore and overlies a portion of the top surface 27 of the insertion head. In the example shown, the first end 52 of the tube is spaced from both the shearing edge and the shoulder surface of the body 20. As one will appreciate, the tube 50 positioned within the bore of the body forms the "conduit" 40 described in reference to Figs. 3A-3C.
Referring to Figs. 3A to 4C, the conduit may comprise a wicking member 60 that is constructed and arranged for regulating the flow of aqueous humor from an inlet end 62 to an outlet end 64 of the wicking member. This wicking member may, in one example, be a porous material suitable for insertion within at least a portion of the conduit. Such a wicking member 60 may be readily used in the embodiment shown in Fig. 3A.
Alternatively, the wicking member 60 may be a porous material surrounded by a non-porous sheath.
Such a sheathed wicking member could be used as the "tube" in the embodiment shown in Figs. 4A-4C. Alternatively, the wicking member 60 could be formed from a plurality of tubular conduits. The flow rate through the wicking member may be controlled selectively choosing among the porosity of the material used, the length of the wicking member, and/or the number and relative size of the tubular conduits used in the respective examples. The use of a wicking member 60 allows for the variation of outflow required from the conduit to relieve undesired intraocular pressure. It is contemplated to provide implant devices of the present invention that would provide the desired aqueous humor flow to obtain a desired intraocular pressure. Thus, the physician can match the flow rate of the respective implant to the particular need of a patient. For example, versions of the device could be offered in various flow rates and/or pressure gradients.
Turning to Figs. 5A-5C, an alternative embodiment of the device is shown that includes a wicking member 60. Here, an upper surface 36 of the elongate body defines a longitudinally extending slit 39. In one example, the slit extends from the forward end to the back end of the body. In this embodiment, the wicking member 60 is constructed and arranged so that the flow of aqueous humor from the inlet end 62 to the outlet end 64 is regulated and aqueous humor entering the inlet end can only exit the outlet end, which is placed in communication with the suprachoroidal space. The wicking member 60 is positioned within at least a portion of the slit of the body and overlies a portion of the top surface 27 of the insertion head 26. The inlet end 62 of the wicking member is spaced from the shearing edge of the body and, in one example, the inlet end is positioned at an acute angle with respect to the top surface of the insertion head.
Referring now to Figs. 3A, 4C, and 5C, the elongate body provides a means for grasping the body by a surgical tool such as, for example, forceps and the like. In one example, as shown in Fig. 5C, at least one planar surface 70 constructed and arranged for grasping by the surgical tool is defined on at least a portion of at least one of the respective upper and lower surfaces of the elongate body. In this example, a portion of the slit in the elongate body forms one planar surface.
Alternatively, as shown in Figs. 3A and 4C, the elongate body 20 may define a longitudinally extending groove 80, extending from the back end of the body, in the exterior surface of the body. The groove 80 is constructed and arranged for grasping by the surgical tool. One will appreciate that the groove may be positioned in the upper surface or in the lower surface of the body. Alternatively, a second longitudinally extending groove or a planar surface may be defined in the opposite spaced respective upper or lower surface to facilitate secure grasping of the device. As one will appreciate, any combination of planar surfaces and/or grooves on the respective upper and lower surfaces may be used to provide suitable grasping surfaces for the surgical tool.
After implantation the shunt may be fixed to a portion of the sclera of the eye. In the example shown in Fig. 5C, to facilitate fixation, the shunt may have at least one stitching loop 100 defined in the elongate body. Sutures can be passed through the loop and secured to the sclera. In the example shown in Fig. 4A, the elongate body has a pair of spaced notches 110 that are constructed and arranged for facilitating suturing of the elongate body to eye tissue. Here, one notch of the pair of spaced notches is defined in each respective elongate edge of the body. Further, each notch may have a keyhole shape. In another example shown in Fig. 3A, the body has at least a pair of spaced bores 120 extending between the upper and lower surfaces of the body. As one will appreciate, a suture can be passed through the bores for subsequent securing to the sclera. To simplify the surgical procedure, at least one suture may be preloaded into the stitching loop, notches, bores, and the like of the device prior to inserting the device into the eye.

The device of the present invention is designed to be implanted through an incision or cleft formed in the anterior chamber angle of the eye by the shearing edge of the shunt 10.
Because of the simplicity of the insertion of the device and the similarities to the traditional cyclodialysis procedure, the method and device should be readily accepted by general ophthalmologists who can incorporate the use of the implant easily into already established surgical techniques. It would thus present an attractive and cost effective technological alternative for an eye surgeon. Because the procedure can be done quickly with minimum instrumentation, the device of the present invention would be especially advantageous in developing nations, where glaucoma is a leading cause of blindness.
Turning now to Figs. 6A-7B, the surgical method for implanting the device of the present invention into an eye will be explained. A first incision or slit is made through the conjunctiva and the sclera at a location rearward of the limbus, that is, posterior to the region of the sclera at which the opaque white sclera starts to become clear cornea.
Preferably, the first incision is made about 3mm posterior to the limbus. Also, the first incision is made slightly larger than the width of the implant device. A conventional cyclodialysis spatula may be inserted through the first incision into the supraciliary space to confirm correct anatomic position.
A portion of the upper and lower surfaces of the shunt 10 proximate the back end of the body is then grasped securely by the surgical tool, for example, a forceps, so that the forward end of the shunt is oriented properly. In one example, the shunt is oriented with the longitudinal axis of the device being substantially co-axial to the longitudinal axis of the grasping end of the surgical tool. The shunt 10 is then disposed through the first incision and into the supraciliary space of the eye. The shearing edge of the shunt is advanced anteriorly in the supraciliary space and is inserted into and through the anterior chamber angle of the eye. More particularly, the shearing edge of the insertion head passes preferably between the scleral spur and the ciliary body posterior to the trabecular meshwork. The shunt is continually advanced anteriorly until a portion of the insertion head and the first end of the conduit is disposed within the anterior chamber of the eye. Thus, the first end of the conduit is placed into fluid communication with the anterior chamber of the eye. The back end of the elongate body is disposed into the suprachoroidal space of the eye so that the second end of the conduit is placed into fluid communication with the suprachoroidal space.
The shoulder surface of the forward end of the shunt is seated proximate an interior surface of the supraciliary space and is not introduced into the anterior chamber. The shoulder surface aids in forming a tight seal to prevent leakage of aqueous humor around the device as well as helping to prevent unwanted further anterior movement of the shunt. The shape of the cleft formed by the insertion head forms a tight seal about the exterior surface of the body, and, if used, the fusiform cross-sectional shape of the body prevents gaping of the formed cleft on either elongate edge of the shunt.
The shunt is then sutured to a portion of the sclera to aid in fixating the shunt. The first incision is subsequently sutured closed. As one will appreciate, the suture used to fixate the shunt may also be used to close the first incision.
It will be seen that upon implantation, the drainage device forms a cyclodialysis with the conduit providing transverse communication of aqueous humor through the shunt along its length. Aqueous humor thus delivered to the suprachoroidal space will then be absorbed therein, and additional reduction in pressure within the eye is to be expected.

The device may be made from any biological inert and biocompatible materials having the desired characteristics. The elongate body may be substantially rigid or may be substantially resilient and semi-rigid. Further, the exterior surface of the elongate body is non-porous. Various medically suitable acrylics and other plastics are considered appropriate. The finish of the device should be to the standard for ophthalmic devices and should not create irritation to surrounding tissue. In one example, the device may be made by conventional liquid injection molding or transfer molding process.
It will be apparent to those skilled in the art that various modifications and variations can be made in the present invention without departing from the scope or spirit of the invention. Other embodiments of the invention will be apparent to those skilled in the art from consideration of the specification and practice of the invention disclosed herein. It is intended that the specification and examples be considered as exemplary only, with a true scope and spirit of the invention being indicated by the following claims.

Claims (10)

1. A use of a biocompatible ophthalmic shunt, said shunt comprising:
i. an elongate body having a forward end, a spaced back end, and an insertion head extending from the forward end of the elongate body, the insertion head having a top surface and defining a shearing edge constructed and arranged for cutting eye tissue engaged thereby, a junction of the forward end and the insertion head of said body further defining a shoulder surface, said shoulder extending laterally along the forward end of the elongate body; and ii. an enclosed conduit having a first end defined on a portion of the top surface of said insertion head and extending through said body from the forward end to the back end thereof, the first end being spaced from the shearing edge and the shoulder surface of said body, for lowering eye pressure in an eye when said shunt is disposed within the eye such that at least a portion of the shearing edge of the insertion head of the shunt is within the anterior chamber of the eye and the first end of the conduit is in fluid communication with the anterior chamber.
2. The use of Claim 1, wherein the insertion head is located to seat the shoulder surface of the implant adjacent an interior surface of the supraciliary space of the eye.
3. A use of a biocompatible ophthalmic shunt, said shunt comprising:
i. a thin elongate body of a biocompatible material, the body having a forward end, a spaced back end, and a substantially fusiform cross-sectional shape, said body further comprising an insertion head extending from the forward end of the elongate body, the insertion head having a top surface and defining a shearing edge constructed and arranged for cutting eye tissue engaged thereby, the shearing edge having a substantially arcuate shape, a junction of the forward end and the insertion head of said body further defining a shoulder surface, said shoulder extending laterally along the forward end of the elongate body; and ii. an enclosed conduit defined on a portion of the top surface of said insertion head and extending through said body from the forward end to the back end thereof, the conduit having a first end that is spaced from the shearing edge and the shoulder surface of said body, for treating glaucoma in an eye when said shunt is disposed within the eye such that at least a portion of the shearing edge of the insertion head of the shunt is within the anterior chamber of the eye and the first end of the conduit is in fluid communication with the anterior chamber.
4. The use of Claim 3, wherein the insertion head is located to seat the shoulder surface of the implant adjacent an interior surface of the supraciliary space of the eye.
5. The use of any one of claims 1-4 wherein said use further comprises suturing the implant to a portion of the sclera.
6. A use of a biocompatible ophthalmic shunt, said shunt comprising:
i. a thin elongate body of a biocompatible material, the body having a forward end, a spaced back end, and a substantially fusiform cross-sectional shape, said body further comprising an insertion head extending from the forward end of the elongate body, the insertion head having a top surface and defining a shearing edge constructed and arranged for cutting eye tissue engaged thereby, the shearing edge having a substantially arcuate shape, the forward end and the insertion head of said body defining a shoulder surface; and ii. a conduit defined on a portion of the top surface of said insertion head and extending through said body from the forward end to the back end thereof, the conduit having a first end that is spaced from the shearing edge and the shoulder surface of said body, for treating glaucoma in an eye by inserting at least a portion of the shearing edge of the insertion head of the shunt into and through the anterior chamber angle and into the anterior chamber of the eye; disposing the first end of the conduit into fluid communication with the anterior chamber of the eye, disposing the back end of the elongate body of the shunt into the suprachoroidal space of the eye so that a second end of the conduit is in fluid communication with the suprachoroidal space, and securing the shunt to the eye by suturing a portion of the elongate body to the eye.
7. The use of Claim 6, further comprising in said use suturing the shunt to a portion of the sclera.
8. The use of Claim 6, further comprising in said use introducing the insertion head anteriorally to seat the shoulder surface of the implant adjacent an interior surface of the supraciliary space of the eye.
9. The use of Claim 6, further comprising in said use, prior to the insertion of the insertion head into the anterior chamber, making a first incision in and through the conjunctiva and the sclera at a position posterior to the limbus.
10. The use of Claim 6, further comprising in said use, prior to suturing the first incision closed, forcing the insertion head anteriorally to seat the shoulder surface of the implant adjacent to an interior surface of the supraciliary space of the eye.
CA2744117A 2002-07-19 2003-07-21 Uveoscleral drainage device Abandoned CA2744117A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39756502P 2002-07-19 2002-07-19
US60/397,565 2002-07-19
CA2493010A CA2493010C (en) 2002-07-19 2003-07-21 Uveoscleral drainage device

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2493010A Division CA2493010C (en) 2002-07-19 2003-07-21 Uveoscleral drainage device

Publications (1)

Publication Number Publication Date
CA2744117A1 true CA2744117A1 (en) 2004-01-29

Family

ID=30771081

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2744117A Abandoned CA2744117A1 (en) 2002-07-19 2003-07-21 Uveoscleral drainage device
CA2493010A Expired - Fee Related CA2493010C (en) 2002-07-19 2003-07-21 Uveoscleral drainage device

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2493010A Expired - Fee Related CA2493010C (en) 2002-07-19 2003-07-21 Uveoscleral drainage device

Country Status (13)

Country Link
US (2) US7041077B2 (en)
EP (3) EP1534363B1 (en)
CN (2) CN100591372C (en)
AT (2) ATE419026T1 (en)
AU (1) AU2003256657A1 (en)
BR (1) BR0312816A (en)
CA (2) CA2744117A1 (en)
DE (1) DE60325606D1 (en)
ES (1) ES2320121T3 (en)
HK (1) HK1084313A1 (en)
MX (1) MXPA05000807A (en)
WO (1) WO2004008945A2 (en)
ZA (1) ZA200501458B (en)

Families Citing this family (142)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6203513B1 (en) 1997-11-20 2001-03-20 Optonol Ltd. Flow regulating implant, method of manufacture, and delivery device
US8313454B2 (en) * 1997-11-20 2012-11-20 Optonol Ltd. Fluid drainage device, delivery device, and associated methods of use and manufacture
BR0010055A (en) 1999-04-26 2002-04-09 Gmp Vision Solutions Inc Bypass device and use thereof
US20050119737A1 (en) * 2000-01-12 2005-06-02 Bene Eric A. Ocular implant and methods for making and using same
US6638239B1 (en) 2000-04-14 2003-10-28 Glaukos Corporation Apparatus and method for treating glaucoma
US7708711B2 (en) 2000-04-14 2010-05-04 Glaukos Corporation Ocular implant with therapeutic agents and methods thereof
US7135009B2 (en) 2001-04-07 2006-11-14 Glaukos Corporation Glaucoma stent and methods thereof for glaucoma treatment
JP4206272B2 (en) 2001-03-29 2009-01-07 サイナージィ ファーマスーティカルズ、インコーポレイテッド Guanylate cyclase receptor agonists for treating tissue inflammation and carcinogenesis
US7431710B2 (en) 2002-04-08 2008-10-07 Glaukos Corporation Ocular implants with anchors and methods thereof
US7488303B1 (en) * 2002-09-21 2009-02-10 Glaukos Corporation Ocular implant with anchor and multiple openings
US7678065B2 (en) 2001-05-02 2010-03-16 Glaukos Corporation Implant with intraocular pressure sensor for glaucoma treatment
US7951155B2 (en) 2002-03-15 2011-05-31 Glaukos Corporation Combined treatment for cataract and glaucoma treatment
US9301875B2 (en) 2002-04-08 2016-04-05 Glaukos Corporation Ocular disorder treatment implants with multiple opening
CN100591372C (en) * 2002-07-19 2010-02-24 耶鲁大学 Uveoscleral drainage device
WO2004026347A2 (en) * 2002-09-17 2004-04-01 Iscience Surgical Corporation Apparatus and method for surgical bypass of aqueous humor
US20040225250A1 (en) 2003-05-05 2004-11-11 Michael Yablonski Internal shunt and method for treating glaucoma
CA2529495C (en) * 2003-06-16 2013-02-05 Solx, Inc. Shunt for the treatment of glaucoma
US7291125B2 (en) * 2003-11-14 2007-11-06 Transcend Medical, Inc. Ocular pressure regulation
WO2005072294A2 (en) 2004-01-22 2005-08-11 Solx, Inc. Glaucoma treatment method
US7364564B2 (en) * 2004-03-02 2008-04-29 Becton, Dickinson And Company Implant having MEMS flow module with movable, flow-controlling baffle
US7226540B2 (en) * 2004-02-24 2007-06-05 Becton, Dickinson And Company MEMS filter module
US20060036207A1 (en) * 2004-02-24 2006-02-16 Koonmen James P System and method for treating glaucoma
US20050194303A1 (en) * 2004-03-02 2005-09-08 Sniegowski Jeffry J. MEMS flow module with filtration and pressure regulation capabilities
US7544176B2 (en) * 2005-06-21 2009-06-09 Becton, Dickinson And Company Glaucoma implant having MEMS flow module with flexing diaphragm for pressure regulation
US20060206049A1 (en) * 2005-03-14 2006-09-14 Rodgers M S MEMS flow module with piston-type pressure regulating structure
US20060219627A1 (en) * 2005-03-31 2006-10-05 Rodgers M S MEMS filter module with concentric filtering walls
US20060173399A1 (en) * 2005-02-01 2006-08-03 Rodgers M S MEMS flow module with pivoting-type baffle
US7384550B2 (en) * 2004-02-24 2008-06-10 Becton, Dickinson And Company Glaucoma implant having MEMS filter module
US20090043321A1 (en) * 2004-04-29 2009-02-12 Iscience Interventional Corporation Apparatus And Method For Surgical Enhancement Of Aqueous Humor Drainage
US20100173866A1 (en) * 2004-04-29 2010-07-08 Iscience Interventional Corporation Apparatus and method for ocular treatment
US7862531B2 (en) 2004-06-25 2011-01-04 Optonol Ltd. Flow regulating implants
AU2011253724B2 (en) * 2004-06-25 2013-08-29 Alcon Inc. Flow regulating implants
AR054647A1 (en) 2005-02-21 2007-07-11 Maldonado Bas Arturo DEVICE FOR WATER HUMOR DRAINAGE IN GLAUCOMA CASES
US9084662B2 (en) * 2006-01-17 2015-07-21 Transcend Medical, Inc. Drug delivery treatment device
ES2762239T3 (en) 2006-01-17 2020-05-22 Alcon Inc Glaucoma treatment device
AU2016201445B2 (en) * 2006-01-17 2017-10-26 Alcon Inc. Glaucoma treatment device
US8308701B2 (en) 2010-11-15 2012-11-13 Aquesys, Inc. Methods for deploying intraocular shunts
US20120123317A1 (en) * 2010-11-15 2012-05-17 Aquesys, Inc. Methods for implanation of glaucoma shunts
US8852137B2 (en) 2010-11-15 2014-10-07 Aquesys, Inc. Methods for implanting a soft gel shunt in the suprachoroidal space
US8801766B2 (en) 2010-11-15 2014-08-12 Aquesys, Inc. Devices for deploying intraocular shunts
US9095411B2 (en) 2010-11-15 2015-08-04 Aquesys, Inc. Devices for deploying intraocular shunts
US10085884B2 (en) 2006-06-30 2018-10-02 Aquesys, Inc. Intraocular devices
US20080108933A1 (en) * 2006-06-30 2008-05-08 Dao-Yi Yu Methods, Systems and Apparatus for Relieving Pressure in an Organ
US8663303B2 (en) 2010-11-15 2014-03-04 Aquesys, Inc. Methods for deploying an intraocular shunt from a deployment device and into an eye
US8758290B2 (en) 2010-11-15 2014-06-24 Aquesys, Inc. Devices and methods for implanting a shunt in the suprachoroidal space
US20120123316A1 (en) 2010-11-15 2012-05-17 Aquesys, Inc. Intraocular shunts for placement in the intra-tenon's space
US8721702B2 (en) 2010-11-15 2014-05-13 Aquesys, Inc. Intraocular shunt deployment devices
US8852256B2 (en) 2010-11-15 2014-10-07 Aquesys, Inc. Methods for intraocular shunt placement
US8828070B2 (en) 2010-11-15 2014-09-09 Aquesys, Inc. Devices for deploying intraocular shunts
US8974511B2 (en) 2010-11-15 2015-03-10 Aquesys, Inc. Methods for treating closed angle glaucoma
AU2013206830B2 (en) * 2006-07-11 2015-09-24 Refocus Group, Inc. Scleral prosthesis for treating presbyopia and other eye disorders and related devices and methods
EP3351211B1 (en) * 2006-07-11 2023-09-06 Refocus Group, Inc. Scleral prosthesis for treating presbyopia and other eye disorders
US8911496B2 (en) 2006-07-11 2014-12-16 Refocus Group, Inc. Scleral prosthesis for treating presbyopia and other eye disorders and related devices and methods
JP5748407B2 (en) 2006-11-10 2015-07-15 グローコス コーポレーション Uveal sclera shunt
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CN101772513B (en) 2007-06-04 2013-11-13 协同医药品公司 Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
WO2008154502A1 (en) * 2007-06-07 2008-12-18 Yale University Uveoscleral drainage device
EP2173289A4 (en) 2007-07-17 2010-11-24 Transcend Medical Inc Ocular implant with hydrogel expansion capabilities
US20090082862A1 (en) 2007-09-24 2009-03-26 Schieber Andrew T Ocular Implant Architectures
US20170360609A9 (en) 2007-09-24 2017-12-21 Ivantis, Inc. Methods and devices for increasing aqueous humor outflow
US8734377B2 (en) 2007-09-24 2014-05-27 Ivantis, Inc. Ocular implants with asymmetric flexibility
US7740604B2 (en) 2007-09-24 2010-06-22 Ivantis, Inc. Ocular implants for placement in schlemm's canal
US8808222B2 (en) 2007-11-20 2014-08-19 Ivantis, Inc. Methods and apparatus for delivering ocular implants into the eye
US8512404B2 (en) 2007-11-20 2013-08-20 Ivantis, Inc. Ocular implant delivery system and method
US8109896B2 (en) 2008-02-11 2012-02-07 Optonol Ltd. Devices and methods for opening fluid passageways
US9517359B2 (en) 2009-02-18 2016-12-13 Eye Tech Care High intensity focused ultrasound device with a concave segment shaped transducer for eye treatment
EP2092916A1 (en) 2008-02-19 2009-08-26 Institut National De La Sante Et De La Recherche Medicale (Inserm) A method of treating an ocular pathology by applying high intensity focused ultrasound and device thereof
JP2011513002A (en) 2008-03-05 2011-04-28 イバンティス インコーポレイテッド Method and apparatus for treating glaucoma
EP2296685B1 (en) 2008-06-04 2015-09-02 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
AU2009256157B2 (en) 2008-06-04 2014-12-18 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
ES2640867T3 (en) 2008-06-25 2017-11-07 Novartis Ag Eye implant with ability to change shape
JP2011528375A (en) 2008-07-16 2011-11-17 シナジー ファーマシューティカルズ インコーポレイテッド Guanylate cyclase agonists useful for the treatment of gastrointestinal disorders, inflammation, cancer, and other disorders
US20100056977A1 (en) * 2008-08-26 2010-03-04 Thaddeus Wandel Trans-corneal shunt and method
CN102292050A (en) * 2008-11-19 2011-12-21 瑞福克斯集团公司 Artificial intraocular lens, altered natural crystalline lens, or refilled natural crystalline lens capsule with one or more scleral prostheses for improved performance
JP5964589B2 (en) 2008-12-03 2016-08-03 シナジー ファーマシューティカルズ インコーポレイテッド Preparation of guanylate cyclase C agonist and method of use thereof
CN102238926B (en) * 2008-12-05 2015-09-16 伊万提斯公司 For ocular implants being transported to the method and apparatus in eyes
US8425473B2 (en) * 2009-01-23 2013-04-23 Iscience Interventional Corporation Subretinal access device
US20100191177A1 (en) * 2009-01-23 2010-07-29 Iscience Interventional Corporation Device for aspirating fluids
EP2548538B1 (en) 2009-01-28 2020-04-01 Alcon Inc. Implantation systems for ocular implants with stiffness qualities
US10206813B2 (en) 2009-05-18 2019-02-19 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
AU2010271274B2 (en) 2009-07-09 2015-05-21 Alcon Inc. Single operator device for delivering an ocular implant
AU2010271218B2 (en) 2009-07-09 2017-02-02 Alcon Inc. Ocular implants and methods for delivering ocular implants into the eye
EP2480186A1 (en) * 2009-09-21 2012-08-01 Vidus Ocular, Inc. Uveoscleral drainage device
EP2490621A4 (en) 2009-10-23 2013-04-03 Ivantis Inc Ocular implant system and method
US20110105990A1 (en) * 2009-11-04 2011-05-05 Silvestrini Thomas A Zonal drug delivery device and method
US8529492B2 (en) 2009-12-23 2013-09-10 Trascend Medical, Inc. Drug delivery devices and methods
WO2011083358A1 (en) 2010-01-11 2011-07-14 Eye Tech Care Device for treating an ocular pathology by applying doses of laser energy
WO2011163505A1 (en) 2010-06-23 2011-12-29 Ivantis, Inc. Ocular implants deployed in schlemm's canal of the eye
AU2011302006A1 (en) 2010-09-15 2013-03-07 Synergy Pharmaceuticals Inc. Formulations of guanylate cyclase C agonists and methods of use
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
US20160256319A1 (en) 2010-11-15 2016-09-08 Aquesys, Inc. Intraocular shunt placement in the suprachoroidal space
US8585629B2 (en) 2010-11-15 2013-11-19 Aquesys, Inc. Systems for deploying intraocular shunts
US9668915B2 (en) 2010-11-24 2017-06-06 Dose Medical Corporation Drug eluting ocular implant
EP3685801A1 (en) 2011-02-04 2020-07-29 ForSight Vision6, Inc. Intraocular accommodating lens
US10245178B1 (en) 2011-06-07 2019-04-02 Glaukos Corporation Anterior chamber drug-eluting ocular implant
US8657776B2 (en) 2011-06-14 2014-02-25 Ivantis, Inc. Ocular implants for delivery into the eye
EP4193907A1 (en) 2011-09-13 2023-06-14 Glaukos Corporation Intraocular physiological sensor
US8765210B2 (en) 2011-12-08 2014-07-01 Aquesys, Inc. Systems and methods for making gelatin shunts
US10080682B2 (en) 2011-12-08 2018-09-25 Aquesys, Inc. Intrascleral shunt placement
US9808373B2 (en) 2013-06-28 2017-11-07 Aquesys, Inc. Intraocular shunt implantation
US9610195B2 (en) 2013-02-27 2017-04-04 Aquesys, Inc. Intraocular shunt implantation methods and devices
US8852136B2 (en) 2011-12-08 2014-10-07 Aquesys, Inc. Methods for placing a shunt into the intra-scleral space
US8663150B2 (en) 2011-12-19 2014-03-04 Ivantis, Inc. Delivering ocular implants into the eye
US9101444B2 (en) 2012-01-12 2015-08-11 Innfocus, Inc. Method, surgical kit and device for treating glaucoma
CN103284831A (en) * 2012-02-29 2013-09-11 北京大学第三医院 Foldable glaucoma aqueous humor drainage device
US9358156B2 (en) 2012-04-18 2016-06-07 Invantis, Inc. Ocular implants for delivery into an anterior chamber of the eye
US10085633B2 (en) 2012-04-19 2018-10-02 Novartis Ag Direct visualization system for glaucoma treatment
US9241832B2 (en) 2012-04-24 2016-01-26 Transcend Medical, Inc. Delivery system for ocular implant
US8888734B2 (en) * 2012-06-05 2014-11-18 Alcon Research, Ltd. Functionally graded material tube and method for use of the same in implantation
EP3228286A1 (en) 2012-09-17 2017-10-11 Novartis AG Expanding ocular impant devices
WO2014078288A1 (en) 2012-11-14 2014-05-22 Transcend Medical, Inc. Flow promoting ocular implant
US10617558B2 (en) 2012-11-28 2020-04-14 Ivantis, Inc. Apparatus for delivering ocular implants into an anterior chamber of the eye
US9125723B2 (en) 2013-02-19 2015-09-08 Aquesys, Inc. Adjustable glaucoma implant
US10159600B2 (en) 2013-02-19 2018-12-25 Aquesys, Inc. Adjustable intraocular flow regulation
US9730638B2 (en) 2013-03-13 2017-08-15 Glaukos Corporation Intraocular physiological sensor
US9592151B2 (en) 2013-03-15 2017-03-14 Glaukos Corporation Systems and methods for delivering an ocular implant to the suprachoroidal space within an eye
US9708367B2 (en) 2013-03-15 2017-07-18 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
US9987163B2 (en) 2013-04-16 2018-06-05 Novartis Ag Device for dispensing intraocular substances
JP6574780B2 (en) 2013-11-14 2019-09-11 アクエシス, インコーポレイテッド Intraocular shunt inserter
US20150342875A1 (en) 2014-05-29 2015-12-03 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
US9925088B2 (en) * 2014-06-06 2018-03-27 Janssen Biotech, Inc. Sub-retinal tangential needle catheter guide and introducer
PE20151266A1 (en) * 2014-07-01 2015-09-10 Velasquez Mario Eduardo Miranda DRAINAGE DEVICE FOR THE CONTROL OF INTRAOCULAR PRESSURE IN GLAUCOMA
WO2016011056A1 (en) 2014-07-14 2016-01-21 Ivantis, Inc. Ocular implant delivery system and method
US10219936B2 (en) * 2014-09-11 2019-03-05 Orbit Biomedical Limited Therapeutic agent delivery device with advanceable cannula and needle
FR3034320B1 (en) 2015-03-31 2017-04-28 Eye Tech Care ULTRASOUND TREATMENT OCULAR PROBE
FR3034308B1 (en) * 2015-03-31 2022-01-21 Philippe Sourdille OPHTHALMOLOGICAL INTERPOSITION IMPLANT
UA122570C2 (en) 2015-06-03 2020-12-10 Аквісіс, Інк. Ab externo intraocular shunt placement
EP4265231A3 (en) 2015-08-14 2023-12-20 Alcon Inc. Ocular implant with pressure sensor
WO2017040853A1 (en) 2015-09-02 2017-03-09 Glaukos Corporation Drug delivery implants with bi-directional delivery capacity
US11564833B2 (en) 2015-09-25 2023-01-31 Glaukos Corporation Punctal implants with controlled drug delivery features and methods of using same
TW201722377A (en) * 2015-12-16 2017-07-01 諾華公司 Devices and methods for a cannula-delivered treatment material application device
CA3022830A1 (en) 2016-04-20 2017-10-26 Harold Alexander Heitzmann Bioresorbable ocular drug delivery device
RU2018142990A (en) 2016-06-02 2020-06-05 Эквисис, Инк. INTERNAL EYE DELIVERY OF MEDICINES
EP3463226B1 (en) 2016-06-03 2020-08-05 New World Medical, Inc. Intraocular drainage device
WO2019051475A1 (en) * 2017-09-11 2019-03-14 Oregon Health & Science University Glaucoma tube implant with modulated flow
US11246753B2 (en) 2017-11-08 2022-02-15 Aquesys, Inc. Manually adjustable intraocular flow regulation
US10952898B2 (en) 2018-03-09 2021-03-23 Aquesys, Inc. Intraocular shunt inserter
US11135089B2 (en) 2018-03-09 2021-10-05 Aquesys, Inc. Intraocular shunt inserter
CN108433748A (en) * 2018-04-11 2018-08-24 中山大学中山眼科中心 The harvester of liquid sample with valve
US10369049B1 (en) * 2018-08-17 2019-08-06 Iridex Corporation Probes having fiber taper and fluid collection channel for ophthalmic laser treatment
KR102390116B1 (en) * 2019-11-19 2022-04-25 주식회사 마이크로트 Implant device for lowering intraocular pressure with easy and safe method
JP2024503989A (en) 2021-01-11 2024-01-30 アルコン インコーポレイティド Systems and methods for viscoelastic delivery

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4037604A (en) * 1976-01-05 1977-07-26 Newkirk John B Artifical biological drainage device
US4099529A (en) * 1976-09-20 1978-07-11 Peyman Gholam A Wide-angle cutter vitrophage
US4521210A (en) * 1982-12-27 1985-06-04 Wong Vernon G Eye implant for relieving glaucoma, and device and method for use therewith
US4634418A (en) * 1984-04-06 1987-01-06 Binder Perry S Hydrogel seton
US4604087A (en) * 1985-02-26 1986-08-05 Joseph Neil H Aqueous humor drainage device
NZ215409A (en) * 1986-03-07 1989-02-24 Anthony Christopher Be Molteno Implant for drainage of aqueous humour in glaucoma
US5071408A (en) * 1988-10-07 1991-12-10 Ahmed Abdul Mateen Medical valve
US4946436A (en) * 1989-11-17 1990-08-07 Smith Stewart G Pressure-relieving device and process for implanting
US5041081A (en) * 1990-05-18 1991-08-20 Odrich Ronald B Ocular implant for controlling glaucoma
US5476445A (en) * 1990-05-31 1995-12-19 Iovision, Inc. Glaucoma implant with a temporary flow restricting seal
US5454796A (en) * 1991-04-09 1995-10-03 Hood Laboratories Device and method for controlling intraocular fluid pressure
US5171213A (en) * 1991-08-14 1992-12-15 Price Jr Francis W Technique for fistulization of the eye and an eye filtration prosthesis useful therefor
US5346464A (en) * 1992-03-10 1994-09-13 Camras Carl B Method and apparatus for reducing intraocular pressure
US5342370A (en) * 1993-03-19 1994-08-30 University Of Miami Method and apparatus for implanting an artifical meshwork in glaucoma surgery
FR2721499B1 (en) * 1994-06-22 1997-01-03 Opsia Trabeculectomy implant.
US5704907A (en) * 1994-07-22 1998-01-06 Wound Healing Of Oklahoma Method and apparatus for lowering the intraocular pressure of an eye
US6102045A (en) * 1994-07-22 2000-08-15 Premier Laser Systems, Inc. Method and apparatus for lowering the intraocular pressure of an eye
US5601094A (en) * 1994-11-22 1997-02-11 Reiss; George R. Ophthalmic shunt
US5433701A (en) * 1994-12-21 1995-07-18 Rubinstein; Mark H. Apparatus for reducing ocular pressure
US5558630A (en) * 1994-12-30 1996-09-24 Fisher; Bret L. Intrascleral implant and method for the regulation of intraocular pressure
WO1996020742A1 (en) * 1995-01-06 1996-07-11 Wong Vernon G Improve eye implant for relief of glaucoma
FR2747033B1 (en) 1996-04-03 1998-05-22 Parrat Michel Jesus Hubert DYNAMIC MEATIC SHUTTER FOR LACRYMAL CANALICLES
US6142969A (en) * 1996-10-25 2000-11-07 Anamed, Inc. Sutureless implantable device and method for treatment of glaucoma
US6007510A (en) * 1996-10-25 1999-12-28 Anamed, Inc. Implantable devices and methods for controlling the flow of fluids within the body
GB9700390D0 (en) * 1997-01-10 1997-02-26 Biocompatibles Ltd Device for use in the eye
FR2759577B1 (en) * 1997-02-17 1999-08-06 Corneal Ind DEEP SCLERECTOMY IMPLANT
US5882327A (en) * 1997-04-17 1999-03-16 Jacob; Jean T. Long-term glaucoma drainage implant
US5752928A (en) * 1997-07-14 1998-05-19 Rdo Medical, Inc. Glaucoma pressure regulator
US6077299A (en) * 1998-06-22 2000-06-20 Eyetronic, Llc Non-invasively adjustable valve implant for the drainage of aqueous humor in glaucoma
BR0010055A (en) * 1999-04-26 2002-04-09 Gmp Vision Solutions Inc Bypass device and use thereof
US6589203B1 (en) * 2000-01-26 2003-07-08 Peter Mitrev Glaucoma drainage device implant
US7867186B2 (en) 2002-04-08 2011-01-11 Glaukos Corporation Devices and methods for treatment of ocular disorders
US6699211B2 (en) * 2000-08-22 2004-03-02 James A. Savage Method and apparatus for treatment of glaucoma
CN100591372C (en) * 2002-07-19 2010-02-24 耶鲁大学 Uveoscleral drainage device
US7604647B2 (en) * 2004-10-22 2009-10-20 Medical Instrument Development Laboratories, Inc. Ophthalmic cannula insertion tool and method

Also Published As

Publication number Publication date
AU2003256657A1 (en) 2004-02-09
EP1534363A2 (en) 2005-06-01
EP2039380A3 (en) 2011-02-23
BR0312816A (en) 2007-06-26
DE60325606D1 (en) 2009-02-12
ATE550056T1 (en) 2012-04-15
CN100591372C (en) 2010-02-24
AU2003256657A8 (en) 2004-02-09
WO2004008945A3 (en) 2005-02-03
EP2039380A2 (en) 2009-03-25
HK1084313A1 (en) 2006-07-28
US7041077B2 (en) 2006-05-09
EP2039380B1 (en) 2012-03-21
ZA200501458B (en) 2005-09-07
CA2493010C (en) 2011-09-13
US7662123B2 (en) 2010-02-16
MXPA05000807A (en) 2005-06-17
CA2493010A1 (en) 2004-01-29
ATE419026T1 (en) 2009-01-15
US20040015140A1 (en) 2004-01-22
WO2004008945A2 (en) 2004-01-29
US20060155238A1 (en) 2006-07-13
CN1684728A (en) 2005-10-19
WO2004008945A9 (en) 2004-06-10
EP1534363B1 (en) 2008-12-31
EP1534363A4 (en) 2006-09-13
EP2286773A1 (en) 2011-02-23
ES2320121T3 (en) 2009-05-19
EP2286773B1 (en) 2012-10-17
CN101791258A (en) 2010-08-04

Similar Documents

Publication Publication Date Title
CA2493010C (en) Uveoscleral drainage device
JP4688444B2 (en) Shunt device and method for treating glaucoma
US20190046355A1 (en) System and method for treating an ocular disorder
US20080306429A1 (en) Uveoscleral drainage device
US7641627B2 (en) Method and apparatus for reducing intraocular pressure
US20130281910A1 (en) Ocular implant system
US20210177657A1 (en) Ocular device for treating glaucoma and related minimally invasive glaucoma surgery method
EP1707166A1 (en) Irrigation tip
US20090177138A1 (en) Shunt Device for Glaucoma Treatment
JP2013523213A (en) Fluid discharge device, supply device, and related methods of use and manufacturing
WO2002080829A2 (en) Method and apparatus for treatment of glaucoma
CA2774610A1 (en) Uveoscleral drainage device
JP4346438B2 (en) Methods and intrascleral implants for the treatment of glaucoma and presbyopia

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued

Effective date: 20131224